Przeglad dermatologiczny最新文献

In 67 patients with allergic dermatitis the levels of total IgE and specific IgEs against 14 allergens were determined by the FAST-test method. The most frequently raised levels of specific IgE were found against the following allergens: dog epidermis, timothy grass, Candida albicans, beef. Test by FAST method confirmed increased levels of total and specific IgEs in most cases of atopic dermatitis.

The production of interleukin-1 (IL-1) and interleukin-1 inhibitor by keratinocytes isolated from the skin of epidermodysplasia verruciformis patients was studied. Keratinocytes from uninvolved skin of patients with most pronounced neoplastic lesions produced large amounts of an IL-1 inhibitor (20-40 kD). Keratinocytes from preneoplastic lesions showed no significant differences compared to cells from healthy donors but their production of IL-1 after UVB irradiation was increased.

The natural killer (NK) activity against fetal chondrocytes was studied in patients with psoriasis and systemic sclerosis. It was shown that the cell responsible for the cytotoxic effect is a lymphocyte CD16+, CD2-. In patients with arthritic psoriasis NK activity against chondrocytes was significantly higher than in other psoriasis patients or in healthy controls. Preliminary studies show that the NK activity against chondrocytes is decreased in patients with systemic sclerosis.

A typical case of Werner's syndrome was described. All characteristic features were present i.e.: atrophy of muscle and subcutaneous tissue, especially in distal parts of limbs, reduced and gray hairs, numerous atrophic ulcers and hyperkeratotic lesions in points under the pressure (elbow, feet), diffused osteoporosis in all bones, the most intensive in hands and feet, activity dental caries, bilateral cataract, high pitched, horse voice, caused by atrophy of voice cords, endocrinologic disturbances especially concerning testosterone, follicle stimulating hormone, and prolactin, hypoplasia of external genitals, the abnormal blood glucose curve. Far reaching resemblance of the Werner's syndrome to the physiological senility was emphasized. Good reaction to anabolic drugs was described.

Observations are reported carried out on the course and treatment of enteropathic acrodermatitis in 14 children. In the children the characteristic clinical picture before treatment was associated with low serum zinc level. Determination of serum zinc level during the treatment with zinc sulphate is without decisive importance for the selection of maintenance doses and the drug must be taken often during many years. In the choice of the therapeutic dose the clinical effects should be taken into account, and the dose may not be so high that it would normalized serum zinc level.

The aim of the investigation was to demonstrate whether there is a correlation, in patients with bullous pemphigoid (BP), between the presence of immune deposits in the skin and the activity of the pathological process. We investigated 39 cases with a BP anamnese dating from 3 months up to 17 years. We repeated the investigations several times by means of direct immunofluorescence method in different disease activity. It was demonstrated that there is a complete correlation between the disappearance of the immune deposits in the skin and the remission of the disease. Moreover, it has been shown, that the complement disappears earlier than IgG fraction. These results show the role of the antibasement zone antibodies and especially the complement in the inducement of BP lesions.

Tigason was applied in 51 patients with psoriasis and 19 with other skin diseases. In 18 patients was applied alone, in 42 combined with PUVA and in 10 with SUP. Roaccutan was applied in 18 patients with acne conglobata et phlegmonous resistant to other methods of treatment. Tigason was found to be a useful drug in psoriasis and some other skin diseases. The combination with PUVA or SUP allowed to reduce the doses of drugs and the dose of radiation. Roaccutan was found to be a useful drug in severe forms of acne vulgaris. The side effects of the treatment with retinoids were transient and they did not create danger to the patients.

In 47 patients with generalized psoriasis vulgaris and 23 healthy subjects the effectiveness of the hepatic metabolism reflected by drug biotransformation was assessed with the antipyrine elimination test. In the group of psoriatic patients there were 25 men and 22 women and in the control group--age-matched 12 men and 11 women. The half-time of antipyrine was longer and the clearance index was lower in the patients than those in the control group. The differences were statistically significant. After 2 weeks of PUVA or SUP-therapy the differences were more significant. The findings indicate an impairment of the liver metabolic effectiveness reflected by drug biotransformation in psoriatic patients.