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A Tale of Two Treatments: A Randomised Controlled Trial of Mindfulness or Cognitive Behaviour Therapy Delivered Online for People with Rheumatoid Arthritis. 两种治疗的故事:一项针对类风湿关节炎患者的正念或认知行为疗法的随机对照试验。
IF 22.8 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-01-17 DOI: 10.1159/000542489
Louise Sharpe,Madelyne A Bisby,Rachel E Menzies,Jack Benjamin Boyse,Bethany Richmond,Jemma Todd,Amy-Lee Sesel,Blake F Dear
INTRODUCTIONThis study aimed to determine the relative efficacy of mindfulness-based stress reduction (MBSR) or cognitive behaviour therapy (CBT) in comparison to a waitlist control (WLC) for people with rheumatoid arthritis (RA). Participants completed assessments before and after treatment and at 6-month follow-up.METHODSTwo hundred and sixty-nine participants with RA were recruited and randomised in a 2:2:1 ratio to MBSR:CBT:WLC. Participants completed a semi-structured clinical interview for depression and were stratified for history of recurrent depression. We measured the primary outcome of pain interference, as well as pain severity, depression, anxiety, functional ability, and fear of progression. We predicted that MBSR and CBT would result in improvements compared to WLC. We also predicted that those with a history of recurrent depression would benefit more from MBSR than CBT for depression.RESULTSMBSR and CBT were equally efficacious in reducing pain interference compared to WLC. Similar results were found for depression. MBSR demonstrated superior outcomes to CBT for fear of progression at post-treatment and functional ability at 6-month follow-up. CBT only was better than WLC for pain severity at 6-month follow-up. Depressive status did not moderate the efficacy of treatment.CONCLUSIONSMBSR and CBT resulted in statistically and clinically significant changes in pain interference compared to WLC. MBSR was more efficacious than CBT for functional ability and fear of progression, while CBT showed superiority for pain severity. The effect sizes were comparable to those achieved with face-to-face interventions, confirming both online treatments are effective for people with RA.
本研究旨在确定正念减压(MBSR)或认知行为疗法(CBT)与等候名单对照(WLC)对类风湿关节炎(RA)患者的相对疗效。参与者在治疗前后和6个月的随访中完成了评估。方法招募269名RA患者,按2:2:1的比例随机分配至MBSR:CBT:WLC。参与者完成了抑郁症的半结构化临床访谈,并根据复发性抑郁症的历史进行分层。我们测量了疼痛干扰的主要结局,以及疼痛严重程度、抑郁、焦虑、功能能力和对进展的恐惧。我们预测正念减压和认知行为疗法会比认知行为疗法带来改善。我们还预测,那些有复发性抑郁症病史的人从正念减压疗法中获益比CBT治疗抑郁症更多。结果与WLC相比,smbsr和CBT在减轻疼痛干扰方面同样有效。抑郁症也有类似的结果。在治疗后恐惧进展和6个月随访时的功能能力方面,正念减压疗法表现出优于CBT的结果。在6个月的随访中,CBT在疼痛严重程度上优于WLC。抑郁状态不影响治疗效果。结论与WLC相比,smbsr和CBT对疼痛干扰的影响具有统计学意义和临床意义。正念减压在功能能力和对进展的恐惧方面比CBT更有效,而CBT在疼痛严重程度方面表现出优势。效果大小与面对面干预的效果相当,证实两种在线治疗对类风湿关节炎患者都有效。
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引用次数: 0
Supported Mindfulness-Based Self-Help Intervention as an Adjunctive Treatment for Rapid Symptom Change in Emotional Disorders: A Practice-Oriented Multicenter Randomized Controlled Trial. 支持正念自助干预作为情绪障碍快速症状改变的辅助治疗:一项面向实践的多中心随机对照试验。
IF 16.3 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-01-14 DOI: 10.1159/000542937
Yanjuan Li, Yi Zhang, Chun Wang, Jia Luo, Yang Yu, Shixing Feng, Chunxue Wang, Qianwen Xu, Pengchong Wang, Junxuan Chen, Ning Zhang, Qianmei Yu, Yuqing Liu, Danyun Chen, Stefan G Hofmann, Xinghua Liu

Introduction: Rapid symptom relief is crucial for individuals with emotional disorders. The current study aimed to determine whether facilitator-supported mindfulness-based self-help (MBSH) intervention as an adjunctive treatment could provide rapid improvement for individuals with emotional disorders.

Methods: A practice-oriented randomized controlled trial was conducted on a sample of 302 patients with emotional disorders from four centers. Participants were randomly assigned to either MBSH+TAU (treatment as usual; n = 152) or TAU-only group (n = 150). Assessments were conducted at baseline, week 3, week 5, immediately after intervention and at a 3-month follow-up. Primary outcomes included self-reported and clinician-reported anxiety and depression symptoms. Secondary outcomes included mindfulness, physical symptoms, perceived stress, sleep quality, and inner peace.

Results: The MBSH+TAU group achieved significantly greater improvements in all primary and secondary outcome measures as compared with TAU-only immediately after intervention (Cohen's d = 0.19-0.51). In addition, relatively greater improvements were observed in self-reported depression, mindfulness, physical symptoms, perceived stress, and inner peace as early as week 3 or 5, which were sustained at the 3-month follow-up (Cohen's d = 0.20-0.34).

Conclusions: Facilitator-supported MBSH offers a scalable and effective adjunctive treatment option for patients with emotional disorders in clinical practice, facilitating rapid improvements.

快速缓解症状对情绪障碍患者至关重要。目前的研究旨在确定辅助治疗是否可以为情绪障碍患者提供快速改善。方法:对来自4个中心的302例情绪障碍患者进行面向实践的随机对照试验。参与者被随机分配到MBSH+TAU组(照常治疗;n = 152)或仅tau组(n = 150)。在基线、第3周、第5周、干预后立即和3个月随访时进行评估。主要结局包括自我报告和临床报告的焦虑和抑郁症状。次要结果包括正念、身体症状、感知压力、睡眠质量和内心平静。结果:干预后,MBSH+TAU组与仅TAU组相比,在所有主要和次要结局指标上均取得了显著更大的改善(Cohen’s d = 0.19-0.51)。此外,在自我报告的抑郁、正念、身体症状、感知压力和内心平静方面,早在第3周或第5周就观察到相对较大的改善,并在3个月的随访中持续(Cohen’s d = 0.20-0.34)。结论:促进者支持的MBSH在临床实践中为情绪障碍患者提供了一种可扩展且有效的辅助治疗选择,促进了快速改善。
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引用次数: 0
Metacognitive Training for Subjects with Bipolar Disorder: A Randomized Controlled Trial. 针对双相情感障碍受试者的元认知训练:随机对照试验
IF 16.3 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-01-13 DOI: 10.1159/000542091
Luisa de Siqueira Rotenberg, Renata Curvello, Clara Nardini, Milene da Silva Franco, Maria Eduarda Carozzino, Taís Boeira Biazus, Thuani Campanha, Alia Garrudo Guirado, Grace O'Malley, Thomas J Stamm, Beny Lafer

Introduction: Impairments in social cognition in bipolar disorder (BD) have been extensively described in the last decade but few treatment strategies have been studied to address this issue. This study presents findings from a randomized controlled trial (RCT) investigating the efficacy of metacognitive training for bipolar disorder (MCT-BD) compared to Treatment as Usual (TAU) among individuals with BD in remission. The aim was to determine whether MCT-BD could improve social cognition and overall functioning in this population.

Methods: Participants (N = 56) were recruited via social media and an internal database at the University of São Paulo Medical School. Inclusion criteria included a confirmed BD diagnosis, current state of remission, and the presence of social functioning impairments. Exclusion criteria included any impairments that could hinder neuropsychological testing. Patients were randomly assigned to either MCT-BD or TAU, with assessments conducted at baseline and follow-up. The MCT-BD program consisted of nine sessions.

Results: The overall attendance rate across all MCT-BD intervention sessions was 96.6%. The MCT-BD program demonstrated added value in improving social cognition, specifically in emotion recognition reaction time. However, no significant changes were found in theory of mind, psychosocial functioning, or quality of life.

Conclusion: This RCT provides preliminary evidence for the efficacy of MCT-BD in improving emotion recognition latency, emphasizing the importance of targeted interventions in social cognition outcomes for individuals with BD. The study's strengths include high completion rates and comprehensive cognitive assessments. Future studies should explore long-term effects and personalized treatment approaches aiming to improve social-cognitive deficits in this population.

导读:在过去的十年中,双相情感障碍(BD)的社会认知障碍已经被广泛描述,但很少有治疗策略被研究来解决这个问题。本研究介绍了一项随机对照试验(RCT)的结果,该试验调查了双相情感障碍缓解期患者元认知训练(MCT-BD)与常规治疗(TAU)的疗效。目的是确定MCT-BD是否可以改善这一人群的社会认知和整体功能。方法:通过社交媒体和圣保罗大学医学院的内部数据库招募参与者(N = 56)。纳入标准包括确诊的双相障碍诊断、目前的缓解状态和存在社会功能障碍。排除标准包括任何可能妨碍神经心理测试的损伤。患者被随机分配到MCT-BD或TAU组,并在基线和随访时进行评估。MCT-BD项目包括9个阶段。结果:所有MCT-BD干预疗程的总体出勤率为96.6%。MCT-BD程序在改善社会认知,特别是情绪识别反应时间方面显示出附加价值。然而,在心理理论、社会心理功能或生活质量方面没有发现明显的变化。结论:本RCT为MCT-BD改善情绪识别潜伏期的有效性提供了初步证据,强调了有针对性的干预对双相障碍患者社会认知结果的重要性。本研究的优势在于完成率高,认知评估全面。未来的研究应该探索旨在改善这一人群社会认知缺陷的长期效果和个性化治疗方法。
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引用次数: 0
Active Components in Internet-Based Cognitive-Behavioral Therapy for Social Anxiety Disorder: A Randomized Full Factorial Trial. 基于互联网的社交焦虑症认知行为疗法中的活性成分:随机全因子试验。
IF 16.3 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-01-10 DOI: 10.1159/000542425
Dajana Šipka, Rodrigo Lopes, Tobias Krieger, Jan Philipp Klein, Thomas Berger

Introduction: Many studies have demonstrated that social anxiety disorder (SAD) can be effectively treated with psychotherapy, particularly cognitive-behavioral therapy (CBT), including internet-based CBT (ICBT). Despite evidence-based treatments, many individuals do not sufficiently benefit from them. Identifying the active components could help improve the effectiveness of SAD treatment. This study tested the effects of four treatment components (psychoeducation, cognitive restructuring, attention training, and exposure) within ICBT for SAD to investigate its active components.

Methods: This randomized full factorial trial consisted of four factors (i.e., treatment components) and 16 conditions. A total of 464 adults with a diagnosed SAD were recruited from the community. The primary outcome was SAD symptoms at 8 weeks (post-assessment). Secondary outcomes included SAD diagnosis, SAD symptoms at follow-up (4 months after post), depression and anxiety symptoms, quality of life, client satisfaction, and adverse effects.

Results: Conditions including psychoeducation and exposure were significantly more effective in reducing SAD symptoms at post compared to conditions without these components. Conditions including cognitive restructuring and attention training did not show superiority over conditions without them at post. However, all treatment conditions significantly reduced symptoms compared to the condition without a treatment component. At follow-up, the superiority of psychoeducation and exposure was not significant anymore due to the version without the respective components catching up.

Conclusion: The findings suggest that while all treatment components of ICBT for SAD are beneficial compared to no treatment, psychoeducation and exposure include specific active components that significantly improve treatment outcomes more quickly in ICBT for SAD.

许多研究表明,社交焦虑障碍(SAD)可以通过心理治疗,特别是认知行为治疗(CBT),包括基于互联网的CBT (ICBT)有效治疗。尽管有循证治疗,但许多人并没有充分受益。确定有效成分有助于提高SAD治疗的有效性。本研究测试了ICBT中四个治疗成分(心理教育、认知重组、注意力训练和暴露)对SAD的影响,以调查其有效成分。方法:该随机全因子试验包括4个因素(即治疗成分)和16个条件。总共从社区招募了464名确诊为SAD的成年人。主要结局是8周时的SAD症状(评估后)。次要结局包括SAD诊断、随访时(术后4个月)的SAD症状、抑郁和焦虑症状、生活质量、患者满意度和不良反应。结果:与没有这些成分的条件相比,包括心理教育和暴露在内的条件在减轻岗位SAD症状方面显着更有效。包括认知重组和注意力训练在内的条件在岗位上并不比没有这些条件的条件表现出优势。然而,与没有治疗成分的情况相比,所有治疗条件都显著减轻了症状。在随访中,心理教育和暴露的优势不再显著,因为版本没有各自的成分追赶。结论:研究结果表明,虽然与不治疗相比,ICBT治疗SAD的所有治疗成分都是有益的,但心理教育和暴露包括特定的活性成分,可以更快地显著改善ICBT治疗SAD的治疗结果。
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引用次数: 0
The Journal's Appreciation. 《华尔街日报》的评论。
IF 16.3 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-12-10 DOI: 10.1159/000542491
Jenny Guidi, Fiammetta Cosci
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引用次数: 0
Bodily Distress and International Classification of Diseases-11: Advances, Loose Ends, and Some Confusion. 身体痛苦与国际疾病分类-11:进展、松散结局和一些困惑。
IF 16.3 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-11-29 DOI: 10.1159/000542424
Peter Henningsen, Bernd Löwe
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引用次数: 0
Hidden Costs: The Clinical and Research Pitfalls of Mistaking Antidepressant Withdrawal for Relapse. 隐性成本:将抗抑郁药停药误认为复发的临床和研究陷阱。
IF 16.3 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-11-28 DOI: 10.1159/000542437
Mark A Horowitz, James Davies
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引用次数: 0
Neuromodulations in Psychiatric Disorders: Emerging Lines of Definition. 精神病的神经调节:新的定义。
IF 16.3 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-11-14 DOI: 10.1159/000542163
Xiaolei Liu, Hongxing Wang
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引用次数: 0
The Power of a Good Word: Enhancing the Efficacy of Analgesics in Clinical Settings. 好话的力量:在临床环境中提高镇痛药的疗效。
IF 16.3 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-11-04 DOI: 10.1159/000541810
Roi Treister, Vered Cohen, Limor Issa, Karine Beiruti Wiegler, Alexander Izakson, Mariana Agostinho

Introduction: Communication between medical staff and patients about treatment efficacy elicits expectations of benefit and improves treatment outcomes. While demonstrated in multiple studies via different research methodologies, uniform communication protocols have not been adopted in clinical practice. Here, we summarize the results of two sister studies aimed at bridging this gap.

Methods: Women undergoing C-section (study 1, randomized controlled trial) and patients undergoing general or otolaryngologic surgeries (study 2, control group design) were recruited and assigned to the "regular communication" (RC) or "enhanced communication" (EC) arms. The EC arm received positive information about treatment, while the RC arm received no such information. In both studies, the primary outcome was change in pain intensity; in study 2, an additional outcome was morphine consumption.

Results: Eighty women successfully completed study 1, and 102 patients successfully completed study 2. In both studies, significant time*group interactions were observed (p < 0.001). The analgesic effect was virtually twice as large in the EC arm compared to the RC arm. In study 2, in the last two timepoints of assessment, participants in the EC arm also consumed fewer doses of opioids than participants in the RC arm (p < 0.001). No significant differences were found in vital signs.

Conclusions: We provide ecological evidence that positive information about treatment significantly decreases pain and opioid consumption during routine clinical care. This study and others could encourage healthcare providers to harness the powerful effects of patients' expectations of benefit to improve analgesics outcomes and, potentially, the outcomes of other symptoms.

导言:医务人员与患者就治疗效果进行沟通,可激发患者对治疗效果的期望,并改善治疗效果。虽然多项研究通过不同的研究方法证明了这一点,但临床实践中尚未采用统一的沟通协议。在此,我们总结了两项姐妹研究的结果,旨在缩小这一差距:方法:我们招募了接受剖腹产手术的妇女(研究 1,随机对照试验)和接受普通外科或耳鼻喉科手术的患者(研究 2,对照组设计),并将她们分配到 "常规沟通"(RC)或 "强化沟通"(EC)组。加强沟通 "组接受有关治疗的正面信息,而 "常规沟通 "组则不接受此类信息。两项研究的主要结果都是疼痛强度的变化;研究 2 的附加结果是吗啡消耗量:结果:80 名女性成功完成了研究 1,102 名患者成功完成了研究 2。在这两项研究中,都观察到了明显的时间*组间相互作用(p < 0.001)。EC组的镇痛效果几乎是RC组的两倍。在研究 2 中,在评估的最后两个时间点,EC 组参与者的阿片类药物用量也少于 RC 组参与者(p < 0.001)。生命体征方面没有发现明显差异:我们提供的生态学证据表明,在常规临床护理过程中,有关治疗的积极信息能显著减少疼痛和阿片类药物的消耗。这项研究和其他研究可以鼓励医疗服务提供者利用患者对获益预期的强大作用来改善镇痛效果,并有可能改善其他症状的治疗效果。
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引用次数: 0
Reconsidering Persistent Somatic Symptoms: A Transdiagnostic and Transsymptomatic Approach. 重新考虑持续性躯体症状:跨诊断和跨症状方法。
IF 16.3 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-29 DOI: 10.1159/000541741
Bernd Löwe, Stephan Zipfel, Omer van den Bergh, Peter Henningsen
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引用次数: 0
期刊
Psychotherapy and Psychosomatics
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