首页 > 最新文献

Proceedings of the Nutrition Society最新文献

英文 中文
Effects of dietary nitrate supplementation on markers of oral health: A systematic review 膳食硝酸盐补充剂对口腔健康指标的影响:系统综述
IF 7 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-07-03 DOI: 10.1017/s0029665124004348
S. Alhulaefi, A. Watson, S.E Ramsay, N. Jakubovics, J. Matu, A. Griffiths, R. Kimble, K. Brandt, OM. Shannon
The oral cavity is a vital part of the digestive system. Poor oral health can impact an individual’s ability to eat and has been associated with increased risk of non-communicable diseases and reduced longevity. Conversely, positive oral health has been associated with improved cardiometabolic, cognitive and systemic health and greater longevity. Consumption of dietary nitrate, which is processed in the mouth into nitrite, and is subsequently converted into nitric oxide (NO) in the body (1), has been demonstrated to reduce blood pressure, improve endothelial function, and enhance exercise performance. Interestingly, recent studies suggest that nitrate consumption could also positively modulate markers of oral health (2). To our knowledge, no systematic review has been published examining the effect of inorganic dietary nitrate on oral health. However, this could be valuable to summarise current state of the knowledge, identify effect modifiers and highlight gaps for future research. Therefore, this systematic review aims to investigate the effects of dietary nitrate supplements on markers of oral health in vivo in randomised controlled trials (RCTs).This study was pre-registered with PROSPERO (CRD42023411159). Five databases (PubMed, The Cochrane Library, CINAHL, MEDLINE, and SPORTDiscus) were searched from inception until March 2023 to identify studies that met the following criteria: adult participants (≥ 18 years) and RCTs investigating the effects of oral dietary nitrate versus placebo on markers of oral health. A narrative synthesis of data was conducted. Risk of bias was assessed using the Cochrane Risk of Bias 2 tool.Nine articles reporting data on 284 participants were included. Nitrate was provided via beetroot juice (six studies), a beetroot-derived supplement dissolved in mineral water (one study), and lettuce juice (two studies). The duration of the interventions ranged from one day to a maximum of six weeks. Dietary nitrate supplementation increased the relative abundance of several individual bacterial genera including Neisseria (increased in three studies) and Rothia (increased in three studies). Dietary nitrate supplementation increased salivary pH (increased in two studies) and decreased salivary acidification resulting from the consumption of a sugar-sweetened beverage (decreased in two studies). Furthermore, dietary nitrate supplementation resulted in a decrease in the gingival inflammation index in one study. Overall, the risk of bias in studies was mixed. One study had a low risk of bias, while the rest were rated as having some concerns. No study was considered to have a high risk of bias.The results show that dietary nitrate is a potential nutritional strategy that can potentially benefit oral health by modifying the oral microbiome, altering salivary pH, and minimising gingival inflammation.
口腔是消化系统的重要组成部分。口腔健康状况不佳会影响个人的进食能力,并与非传染性疾病风险增加和寿命缩短有关。相反,积极的口腔健康与改善心脏代谢、认知和系统健康以及延长寿命有关。膳食中的硝酸盐在口腔中被加工成亚硝酸盐,随后在体内转化为一氧化氮(NO)(1)。有趣的是,最近的研究表明,食用硝酸盐还能积极调节口腔健康指标(2)。据我们所知,目前还没有关于无机膳食硝酸盐对口腔健康影响的系统性综述。然而,这对于总结目前的知识状况、确定效应调节因素和强调未来研究的差距可能很有价值。因此,本系统综述旨在调查随机对照试验(RCT)中膳食硝酸盐补充剂对口腔健康体内指标的影响。研究人员检索了五个数据库(PubMed、The Cochrane Library、CINAHL、MEDLINE 和 SPORTDiscus),检索时间从开始到 2023 年 3 月,以确定符合以下标准的研究:成年参与者(≥ 18 岁)和研究口服硝酸盐与安慰剂对口腔健康指标影响的 RCT。对数据进行了叙述性综合。采用 Cochrane Risk of Bias 2 工具对偏倚风险进行了评估。硝酸盐通过甜菜根汁(6 项研究)、溶于矿泉水的甜菜根提取物补充剂(1 项研究)和莴苣汁(2 项研究)提供。干预时间从一天到最长六周不等。膳食硝酸盐补充剂增加了几个细菌属的相对丰度,包括奈瑟氏菌(在三项研究中增加)和罗伊氏菌(在三项研究中增加)。膳食硝酸盐补充剂提高了唾液 pH 值(两项研究中有所提高),降低了因饮用含糖饮料而导致的唾液酸化(两项研究中有所降低)。此外,在一项研究中,通过膳食补充硝酸盐降低了牙龈炎症指数。总体而言,各项研究的偏倚风险参差不齐。一项研究的偏倚风险较低,而其他研究则被评为存在一些问题。研究结果表明,膳食硝酸盐是一种潜在的营养策略,可通过改变口腔微生物群、改变唾液 pH 值和减少牙龈炎症来促进口腔健康。
{"title":"Effects of dietary nitrate supplementation on markers of oral health: A systematic review","authors":"S. Alhulaefi, A. Watson, S.E Ramsay, N. Jakubovics, J. Matu, A. Griffiths, R. Kimble, K. Brandt, OM. Shannon","doi":"10.1017/s0029665124004348","DOIUrl":"https://doi.org/10.1017/s0029665124004348","url":null,"abstract":"The oral cavity is a vital part of the digestive system. Poor oral health can impact an individual’s ability to eat and has been associated with increased risk of non-communicable diseases and reduced longevity. Conversely, positive oral health has been associated with improved cardiometabolic, cognitive and systemic health and greater longevity. Consumption of dietary nitrate, which is processed in the mouth into nitrite, and is subsequently converted into nitric oxide (NO) in the body <jats:sup>(1)</jats:sup>, has been demonstrated to reduce blood pressure, improve endothelial function, and enhance exercise performance. Interestingly, recent studies suggest that nitrate consumption could also positively modulate markers of oral health <jats:sup>(2)</jats:sup>. To our knowledge, no systematic review has been published examining the effect of inorganic dietary nitrate on oral health. However, this could be valuable to summarise current state of the knowledge, identify effect modifiers and highlight gaps for future research. Therefore, this systematic review aims to investigate the effects of dietary nitrate supplements on markers of oral health <jats:italic>in vivo</jats:italic> in randomised controlled trials (RCTs).This study was pre-registered with PROSPERO (CRD42023411159). Five databases (PubMed, The Cochrane Library, CINAHL, MEDLINE, and SPORTDiscus) were searched from inception until March 2023 to identify studies that met the following criteria: adult participants (≥ 18 years) and RCTs investigating the effects of oral dietary nitrate versus placebo on markers of oral health. A narrative synthesis of data was conducted. Risk of bias was assessed using the Cochrane Risk of Bias 2 tool.Nine articles reporting data on 284 participants were included. Nitrate was provided via beetroot juice (six studies), a beetroot-derived supplement dissolved in mineral water (one study), and lettuce juice (two studies). The duration of the interventions ranged from one day to a maximum of six weeks. Dietary nitrate supplementation increased the relative abundance of several individual bacterial genera including <jats:italic>Neisseria</jats:italic> (increased in three studies) and <jats:italic>Rothia</jats:italic> (increased in three studies). Dietary nitrate supplementation increased salivary pH (increased in two studies) and decreased salivary acidification resulting from the consumption of a sugar-sweetened beverage (decreased in two studies). Furthermore, dietary nitrate supplementation resulted in a decrease in the gingival inflammation index in one study. Overall, the risk of bias in studies was mixed. One study had a low risk of bias, while the rest were rated as having some concerns. No study was considered to have a high risk of bias.The results show that dietary nitrate is a potential nutritional strategy that can potentially benefit oral health by modifying the oral microbiome, altering salivary pH, and minimising gingival inflammation.","PeriodicalId":20751,"journal":{"name":"Proceedings of the Nutrition Society","volume":"26 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141527438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between serum 25-hydroxyvitamin D concentrations and respiratory tract infections requiring hospital admission: analysis of ethnic groups from the UK Biobank cohort 血清中 25- 羟维生素 D 浓度与需要入院治疗的呼吸道感染之间的关系:英国生物库队列中的种族群体分析
IF 7 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-07-03 DOI: 10.1017/s0029665124004610
A. R Bournot, K. H Hart, D. I. Givens, J. A Lovegrove, D. B Bartlett, S. A Lanham-New, A. L Darling
Vitamin D status has been found to be inversely associated with risk of respiratory tract infections (RTIs)(1). It varies by ethnicity, with several ethnic minority groups in the United Kingdom (UK) reported to be at a higher risk of vitamin D deficiency (serum 25-hydroxyvitamin D (25(OH)D) concentrations <25 nmol/L) compared to their white counterparts(2, 3). However, the relationship between serum 25(OH)D concentrations and incidence of RTIs by ethnicity in the UK remains unclear. This study aimed to investigate the association between serum 25(OH)D concentrations and likelihood of hospitalisation for RTI in UK ethnic groups.A nested, case-control study was conducted using data from UK Biobank, which has data for 500k adults for serum 25(OH)D and hospital episodes from linked records. Binary logistic regression models were used to explore the association between serum 25(OH)D concentrations and likelihood of RTIs overall, and by ethnicity.Of the 36,772 participants included in the analysis, 12,638 (34%) were white Caucasian, 10,311 (28%) Asian, 7,138 (19%) black, 4,034 (11%) other, and 2,651 (7%) of mixed ethnicity. In fully adjusted models, compared to participants with a serum 25(OH)D concentration <15 nmol/L (severe deficiency), those with 25-49 nmol/L, 50-74 nmol/L, and ≥75 nmol/L were found to have statistically significantly lower odds of RTI hospitalisation, with odds ratios (ORs) of 0.53 (95% CI: 0.37, 0.75), 0.61 (95% CI: 0.40, 0.92) and 0.54 (95% CI: 0.30, 0.97), respectively. In the subgroup analysis, ethnic minorities and white individuals with vitamin D deficiency (<25 nmol/L) were more likely to be hospitalised with RTI compared to those that were not deficient, with ORs of 1.36 (95% CI: 1.02, 1.81) and 2.03 (95% CI: 1.30, 3.17), respectively. This association was not statistically significant within ethnic minority subgroups when analysed separately.Serum 25(OH)D concentrations above 25 nmol/L are associated with lower likelihood of RTI hospitalisation among UK adults. This finding was noted across white and ethnic minority groups, although ethnic minorities with vitamin D deficiency had a lower likelihood of RTIs compared to white individuals. Further studies are warranted to validate these findings and explore the mechanisms underlying the association between vitamin D status and RTIs in different ethnic groups.AcknowledgementsThis project was conducted using the UK Biobank resource under project 15168.
研究发现,维生素 D 状态与呼吸道感染 (RTI) 风险成反比(1)。据报道,与白人相比,英国一些少数民族群体缺乏维生素 D(血清 25- 羟基维生素 D (25(OH)D) 浓度为 25 nmol/L)的风险较高(2, 3)。然而,英国不同种族的血清 25(OH)D 浓度与 RTI 发病率之间的关系仍不清楚。本研究旨在调查英国不同种族群体中血清25(OH)D浓度与RTI住院可能性之间的关系。本研究使用英国生物库的数据开展了一项嵌套病例对照研究,该生物库拥有50万成年人的血清25(OH)D数据和相关记录中的住院病例数据。在纳入分析的36772名参与者中,12638人(34%)为白种人,10311人(28%)为亚裔,7138人(19%)为黑人,4034人(11%)为其他族裔,2651人(7%)为混合族裔。在完全调整模型中,与血清25(OH)D浓度为15 nmol/L(严重缺乏)的参与者相比,血清25-49 nmol/L、50-74 nmol/L和≥75 nmol/L的参与者发生RTI住院的几率在统计学上显著降低,几率比(OR)分别为0.53(95% CI:0.37,0.75)、0.61(95% CI:0.40,0.92)和0.54(95% CI:0.30,0.97)。在亚组分析中,与不缺乏维生素D的人群相比,缺乏维生素D(25 nmol/L)的少数民族和白人更有可能因RTI住院,OR值分别为1.36(95% CI:1.02,1.81)和2.03(95% CI:1.30,3.17)。在英国成年人中,血清 25(OH)D 浓度高于 25 nmol/L 与 RTI 住院的可能性较低有关。尽管与白人相比,缺乏维生素 D 的少数族裔患 RTI 的可能性较低,但这一发现在白人和少数族裔群体中均有体现。有必要开展进一步的研究来验证这些发现,并探索不同种族群体中维生素 D 状态与 RTI 之间的关联机制。
{"title":"Association between serum 25-hydroxyvitamin D concentrations and respiratory tract infections requiring hospital admission: analysis of ethnic groups from the UK Biobank cohort","authors":"A. R Bournot, K. H Hart, D. I. Givens, J. A Lovegrove, D. B Bartlett, S. A Lanham-New, A. L Darling","doi":"10.1017/s0029665124004610","DOIUrl":"https://doi.org/10.1017/s0029665124004610","url":null,"abstract":"Vitamin D status has been found to be inversely associated with risk of respiratory tract infections (RTIs)<jats:sup>(1)</jats:sup>. It varies by ethnicity, with several ethnic minority groups in the United Kingdom (UK) reported to be at a higher risk of vitamin D deficiency (serum 25-hydroxyvitamin D (25(OH)D) concentrations &lt;25 nmol/L) compared to their white counterparts<jats:sup>(2, 3)</jats:sup>. However, the relationship between serum 25(OH)D concentrations and incidence of RTIs by ethnicity in the UK remains unclear. This study aimed to investigate the association between serum 25(OH)D concentrations and likelihood of hospitalisation for RTI in UK ethnic groups.A nested, case-control study was conducted using data from UK Biobank, which has data for 500k adults for serum 25(OH)D and hospital episodes from linked records. Binary logistic regression models were used to explore the association between serum 25(OH)D concentrations and likelihood of RTIs overall, and by ethnicity.Of the 36,772 participants included in the analysis, 12,638 (34%) were white Caucasian, 10,311 (28%) Asian, 7,138 (19%) black, 4,034 (11%) other, and 2,651 (7%) of mixed ethnicity. In fully adjusted models, compared to participants with a serum 25(OH)D concentration &lt;15 nmol/L (severe deficiency), those with 25-49 nmol/L, 50-74 nmol/L, and ≥75 nmol/L were found to have statistically significantly lower odds of RTI hospitalisation, with odds ratios (ORs) of 0.53 (95% CI: 0.37, 0.75), 0.61 (95% CI: 0.40, 0.92) and 0.54 (95% CI: 0.30, 0.97), respectively. In the subgroup analysis, ethnic minorities and white individuals with vitamin D deficiency (&lt;25 nmol/L) were more likely to be hospitalised with RTI compared to those that were not deficient, with ORs of 1.36 (95% CI: 1.02, 1.81) and 2.03 (95% CI: 1.30, 3.17), respectively. This association was not statistically significant within ethnic minority subgroups when analysed separately.Serum 25(OH)D concentrations above 25 nmol/L are associated with lower likelihood of RTI hospitalisation among UK adults. This finding was noted across white and ethnic minority groups, although ethnic minorities with vitamin D deficiency had a lower likelihood of RTIs compared to white individuals. Further studies are warranted to validate these findings and explore the mechanisms underlying the association between vitamin D status and RTIs in different ethnic groups.AcknowledgementsThis project was conducted using the UK Biobank resource under project 15168.","PeriodicalId":20751,"journal":{"name":"Proceedings of the Nutrition Society","volume":"96 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141527464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of resistance exercise on cardiometabolic health and body composition in obese or overweight individuals undergoing dietary weight loss interventions: A systematic review and meta-analysis 阻力运动对接受饮食减肥干预的肥胖或超重者的心脏代谢健康和身体成分的影响:系统回顾与荟萃分析
IF 7 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-07-03 DOI: 10.1017/s0029665124004622
A. Binmahfoz, A. Dighrir, C.M Gray, S. Gray
Obesity prevalence has tripled in over the past 35 years and has detrimental effects on physical and psychological health<jats:sup>(1)</jats:sup>. Weight loss via dietary intervention is a mainstay for the treatment of obesity and reduces body fat<jats:sup>(2)</jats:sup>, but also results in loss of lean tissue<jats:sup>(3)</jats:sup>. A potential solution to mitigate the loss of lean tissue, and thus enhance the benefits of weight loss, is resistance exercise. The aim of the current systematic review was to examine the impact of resistance exercise on body weight/composition and markers of cardiometabolic health, as well as physical function, in people living with overweight or obesity undergoing dietary weight loss interventions.A search was performed in PubMed, Embase, CINAHL, SCOPUS, Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL) based on the set inclusion and exclusion criteria. Systematic searches yielded N=5147 studies of which n=27 were relevant for inclusion after screening for eligibility. We included randomised controlled clinical trials of adult participants (18-65 years of age) with body mass index (BMI) ≥ 25kg/m2) that compared dietary weight loss interventions including resistance exercise with 1) dietary weight loss interventions including other non-resistance exercise and/or 2) dietary weight loss interventions without any exercise. Resistance exercise was classed as any form of resistance or muscle strengthening exercise (e.g. gym or home- based, supervised or non-supervised, used equipment or body weight only). Key data were extracted, risk of bias was assessed using the Cochrane risk of bias tool, and the quality of evidence assessed using Grades of Recommendation, Assessment, Development and Evaluation (GRADE). Meta-analysis was performed including only studies that compared dietary weight loss plus resistance exercise interventions to diet-only (i.e. not including any other exercise) weight loss interventions to explore differences in body weight/composition and cardiometabolic health changes between diet plus resistance exercise and diet only interventions.Overall, resistance exercise in addition to diet-induced weight loss had no effect on weight loss (mean difference between groups: -0.32kg, 95% confidence interval [CI] -1.00 to 0.35; p=0.35) but did preserve fat free mass (between-group standardised mean difference (SMD): 0.40, 95%, [CI] 0.18 to 0.61; p=0.0003) and increase loss of fat mass (SMD: -0.36, 95% [CI] -0.49 to -0.23; p< 0.00001). Muscular strength was also improved (SMD: 2.36, 95% [CI] 1.38 to 3.34; p=0.00001) by the inclusion of resistance exercise. No effects of resistance exercise were seen in any of the other cardiometabolic markers studied, although data were limited.In people who are obese or overweight, the addition of resistance exercise to dietary restriction may enhance its beneficial effects. Current evidence, therefore, supports the inclusion of resistance exerc
在过去的 35 年里,肥胖症的发病率增加了两倍,并对身体和心理健康造成了有害影响(1)。通过饮食干预减肥是治疗肥胖症的主要方法,可以减少体内脂肪(2),但同时也会导致瘦肉组织的流失(3)。阻力运动是减轻瘦肉组织损失从而提高减肥效果的潜在解决方案。本系统性综述旨在研究阻力运动对接受饮食减肥干预的超重或肥胖患者的体重/组成、心脏代谢健康指标以及身体功能的影响。通过系统性检索,共获得 5147 项研究,其中有 27 项经过资格筛选后符合纳入条件。我们纳入了以体重指数(BMI)≥ 25kg/m2 的成年参与者(18-65 岁)为对象的随机对照临床试验,这些试验对包括阻力运动在内的饮食减肥干预措施与 1) 包括其他非阻力运动在内的饮食减肥干预措施和/或 2) 不进行任何运动的饮食减肥干预措施进行了比较。阻力运动被归类为任何形式的阻力或肌肉强化运动(如健身房或家庭、有监督或无监督、使用器械或仅使用体重)。提取关键数据,使用科克伦偏倚风险工具评估偏倚风险,并使用推荐、评估、发展和评价分级法(GRADE)评估证据质量。荟萃分析仅包括将饮食减肥加阻力运动干预与单纯饮食(即不包括任何其他运动)减肥干预进行比较的研究,以探讨饮食减肥加阻力运动干预与单纯饮食干预在体重/体型和心脏代谢健康变化方面的差异。总体而言,在节食减肥的同时进行阻力运动对体重减轻没有影响(组间平均差异:-0.32 千克,95% 置信区间[CI] -1.00 至 0.35;p=0.35),但确实保持了无脂肪质量(组间标准化平均差异(SMD):0.40,95% [CI] 0.18 至 0.61;p=0.0003),并增加了脂肪质量的减少(SMD:-0.36,95% [CI] -0.49 至 -0.23;p<;0.00001)。阻力运动还能增强肌肉力量(SMD:2.36,95% [CI] 1.38 至 3.34;p=0.00001)。对于肥胖或超重人群,在限制饮食的基础上增加阻力运动可能会增强其有益效果。因此,目前的证据支持在减肥期间进行阻力运动,以减少瘦体重的减少、增加脂肪量的减少并增强肌肉力量。
{"title":"The effects of resistance exercise on cardiometabolic health and body composition in obese or overweight individuals undergoing dietary weight loss interventions: A systematic review and meta-analysis","authors":"A. Binmahfoz, A. Dighrir, C.M Gray, S. Gray","doi":"10.1017/s0029665124004622","DOIUrl":"https://doi.org/10.1017/s0029665124004622","url":null,"abstract":"Obesity prevalence has tripled in over the past 35 years and has detrimental effects on physical and psychological health&lt;jats:sup&gt;(1)&lt;/jats:sup&gt;. Weight loss via dietary intervention is a mainstay for the treatment of obesity and reduces body fat&lt;jats:sup&gt;(2)&lt;/jats:sup&gt;, but also results in loss of lean tissue&lt;jats:sup&gt;(3)&lt;/jats:sup&gt;. A potential solution to mitigate the loss of lean tissue, and thus enhance the benefits of weight loss, is resistance exercise. The aim of the current systematic review was to examine the impact of resistance exercise on body weight/composition and markers of cardiometabolic health, as well as physical function, in people living with overweight or obesity undergoing dietary weight loss interventions.A search was performed in PubMed, Embase, CINAHL, SCOPUS, Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL) based on the set inclusion and exclusion criteria. Systematic searches yielded N=5147 studies of which n=27 were relevant for inclusion after screening for eligibility. We included randomised controlled clinical trials of adult participants (18-65 years of age) with body mass index (BMI) ≥ 25kg/m2) that compared dietary weight loss interventions including resistance exercise with 1) dietary weight loss interventions including other non-resistance exercise and/or 2) dietary weight loss interventions without any exercise. Resistance exercise was classed as any form of resistance or muscle strengthening exercise (e.g. gym or home- based, supervised or non-supervised, used equipment or body weight only). Key data were extracted, risk of bias was assessed using the Cochrane risk of bias tool, and the quality of evidence assessed using Grades of Recommendation, Assessment, Development and Evaluation (GRADE). Meta-analysis was performed including only studies that compared dietary weight loss plus resistance exercise interventions to diet-only (i.e. not including any other exercise) weight loss interventions to explore differences in body weight/composition and cardiometabolic health changes between diet plus resistance exercise and diet only interventions.Overall, resistance exercise in addition to diet-induced weight loss had no effect on weight loss (mean difference between groups: -0.32kg, 95% confidence interval [CI] -1.00 to 0.35; p=0.35) but did preserve fat free mass (between-group standardised mean difference (SMD): 0.40, 95%, [CI] 0.18 to 0.61; p=0.0003) and increase loss of fat mass (SMD: -0.36, 95% [CI] -0.49 to -0.23; p&lt; 0.00001). Muscular strength was also improved (SMD: 2.36, 95% [CI] 1.38 to 3.34; p=0.00001) by the inclusion of resistance exercise. No effects of resistance exercise were seen in any of the other cardiometabolic markers studied, although data were limited.In people who are obese or overweight, the addition of resistance exercise to dietary restriction may enhance its beneficial effects. Current evidence, therefore, supports the inclusion of resistance exerc","PeriodicalId":20751,"journal":{"name":"Proceedings of the Nutrition Society","volume":"34 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141527465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of pre- versus post-conceptional iron and n-3 fatty acid supplementation of deficient rat dams on neurodevelopmental outcomes in the offspring 对缺铁大鼠母体进行孕前和孕后铁和 n-3 脂肪酸补充对后代神经发育结果的影响
IF 7 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-07-03 DOI: 10.1017/s0029665124004415
A. Shaw, E.T Kemp, L. Zandberg, B.H Harvey, C.M Smuts, J. Baumgartner
<jats:italic>This abstract was awarded the Student Competition Prize</jats:italic>.Periconception is the period spanning the weeks directly before and after conception and is a crucial window for optimising neurodevelopment in offspring<jats:sup>(1-4)</jats:sup>. Iron and omega-3 fatty acids (n-3 FAs) are two vital nutrients for the development of the nervous system however, little research has been conducted into their importance during the periconceptional window<jats:sup>(5-8)</jats:sup>. This study investigated whether supplementing iron and n-3 FA deficient (ID and n-3 FAD) rat dams before conception compared to after conception results in different neurodevelopmental outcomes in offspring. We hypothesised that initiating iron and n-3 FA supplementation in deficient dams after conception would not be as efficacious in preventing impaired offspring neurodevelopment induced by double- deficiency, compared to initiating supplementation before conception.Female rats consuming an ID and n-3 FAD diet were randomly allocated to receive iron and DHA/EPA supplementation either 10 days before (Pre-Fe+DHA/EPA) or 10 days after conception (Post-Fe+DHA/EPA). Dams and offspring (Pre-: n = 24; Post-: n = 26) were subsequently maintained on supplemented diets throughout the experiment. Between postnatal days 31–41, cognitive and behavioural tests were conducted on offspring. Offspring were euthanised between postnatal day 42–45 and n-3 FAs, iron and monoamine concentrations were measured in the hippocampus, striatum and frontal cortex. All outcomes were compared to offspring who were either iron and n-3 FA deficient (ID+n-3 FAD: n = 24) or sufficient (Control+Fe+DHA/EPA: n = 22). One-way ANCOVA, with sex as a covariate, was used to determine between-group differences and two-way ANOVA was used to explore diet-sex interactions.There were no differences in brain iron or n-3 FA levels between Pre- and Post-Fe+DHA/EPA offspring (P > 0.05). Female Post-Fe+DHA/EPA offspring had greater norepinephrine concentrations in the frontal cortex (Pre-: 3.21 ± 0.57 ng/mg vs Post-: 2.50 ± 0.55 ng/mg; P = 0.014) and consumed less sucrose in the sucrose preference test (Pre-: 96.16 ± 1.73%; Post-: 90.15 ± 1.66%; P = 0.010) compared to Pre-Fe+DHA/EPA offspring. Female Post-Fe+DHA/EPA offspring also had significantly lower liver iron concentrations compared to female Pre-Fe+DHA/EPA offspring (Pre-: 537 ± 47.13 μg/L vs Post-: 310 ± 45.28 μg/L; P = 0.034). There were no other significant differences in monoamine concentrations or behavioural tests.Our results indicate that supplementing ID and n-3 FAD mothers both before and after conception is efficacious in preventing neurodevelopmental deficits associated with deficiency. However, ID and n-3 FAD during the periconceptional period may alter reward-based learning in female offspring<jats:sup>(9-11)</jats:sup>. Additionally, optimising iron provision during periconception may have important implications for the prevention of p
围孕期是指受孕前后几周的时间,是优化后代神经系统发育的关键时期(1-4)。铁和欧米加-3 脂肪酸(n-3 FAs)是神经系统发育的两种重要营养素,但有关它们在围孕期重要性的研究却很少(5-8)。本研究调查了在受孕前与受孕后补充铁和 n-3 FA 缺乏(ID 和 n-3 FAD)的大鼠母体是否会导致后代神经发育结果的不同。我们假设,与受孕前开始补充铁和 n-3 FA 相比,受孕后开始为铁和 n-3 FA 缺乏的母鼠补充铁和 n-3 FA 对预防双重缺乏引起的后代神经发育受损的效果并不明显。食用 ID 和 n-3 FAD 食物的雌性大鼠被随机分配到受孕前 10 天(Pre-Fe+DHA/EPA)或受孕后 10 天(Post-Fe+DHA/EPA)接受铁和 DHA/EPA 补充。在整个实验过程中,母鼠和后代(前:n = 24;后:n = 26)一直食用添加了铁和 DHA/EPA 的饲料。在出生后第 31-41 天,对后代进行认知和行为测试。后代在出生后第 42-45 天被安乐死,并在海马、纹状体和额叶皮层测量 n-3 脂肪酸、铁和单胺浓度。所有结果均与铁和 n-3 FA 缺乏(ID+n-3 FAD:n = 24)或充足(对照组+铁+DHA/EPA:n = 22)的后代进行比较。以性别作为协变量的单因素方差分析用于确定组间差异,双因素方差分析用于探讨饮食与性别之间的相互作用。与前Fe+DHA/EPA后代相比,后Fe+DHA/EPA雌性后代额叶皮层的去甲肾上腺素浓度更高(前:3.21 ± 0.57 ng/mg vs 后:2.50 ± 0.55 ng/mg; P = 0.014),在蔗糖偏好测试中摄入的蔗糖更少(前:96.16 ± 1.73%; 后:90.15 ± 1.66%; P = 0.010)。与Fe+DHA/EPA前的雌性后代相比,Fe+DHA/EPA后的雌性后代的肝铁浓度也明显较低(前:537 ± 47.13 μg/L vs 后:310 ± 45.28 μg/L;P = 0.034)。我们的研究结果表明,母亲在受孕前后补充 ID 和 n-3 FAD 可有效预防因缺乏而导致的神经发育缺陷。然而,在围孕期补充 ID 和 n-3 FAD 可能会改变雌性后代基于奖励的学习(9-11)。此外,在围孕期优化铁的供给可能对预防产后(尤其是婴儿早期)ID 贫血有重要意义(12)。
{"title":"Effects of pre- versus post-conceptional iron and n-3 fatty acid supplementation of deficient rat dams on neurodevelopmental outcomes in the offspring","authors":"A. Shaw, E.T Kemp, L. Zandberg, B.H Harvey, C.M Smuts, J. Baumgartner","doi":"10.1017/s0029665124004415","DOIUrl":"https://doi.org/10.1017/s0029665124004415","url":null,"abstract":"&lt;jats:italic&gt;This abstract was awarded the Student Competition Prize&lt;/jats:italic&gt;.Periconception is the period spanning the weeks directly before and after conception and is a crucial window for optimising neurodevelopment in offspring&lt;jats:sup&gt;(1-4)&lt;/jats:sup&gt;. Iron and omega-3 fatty acids (n-3 FAs) are two vital nutrients for the development of the nervous system however, little research has been conducted into their importance during the periconceptional window&lt;jats:sup&gt;(5-8)&lt;/jats:sup&gt;. This study investigated whether supplementing iron and n-3 FA deficient (ID and n-3 FAD) rat dams before conception compared to after conception results in different neurodevelopmental outcomes in offspring. We hypothesised that initiating iron and n-3 FA supplementation in deficient dams after conception would not be as efficacious in preventing impaired offspring neurodevelopment induced by double- deficiency, compared to initiating supplementation before conception.Female rats consuming an ID and n-3 FAD diet were randomly allocated to receive iron and DHA/EPA supplementation either 10 days before (Pre-Fe+DHA/EPA) or 10 days after conception (Post-Fe+DHA/EPA). Dams and offspring (Pre-: n = 24; Post-: n = 26) were subsequently maintained on supplemented diets throughout the experiment. Between postnatal days 31–41, cognitive and behavioural tests were conducted on offspring. Offspring were euthanised between postnatal day 42–45 and n-3 FAs, iron and monoamine concentrations were measured in the hippocampus, striatum and frontal cortex. All outcomes were compared to offspring who were either iron and n-3 FA deficient (ID+n-3 FAD: n = 24) or sufficient (Control+Fe+DHA/EPA: n = 22). One-way ANCOVA, with sex as a covariate, was used to determine between-group differences and two-way ANOVA was used to explore diet-sex interactions.There were no differences in brain iron or n-3 FA levels between Pre- and Post-Fe+DHA/EPA offspring (P &gt; 0.05). Female Post-Fe+DHA/EPA offspring had greater norepinephrine concentrations in the frontal cortex (Pre-: 3.21 ± 0.57 ng/mg vs Post-: 2.50 ± 0.55 ng/mg; P = 0.014) and consumed less sucrose in the sucrose preference test (Pre-: 96.16 ± 1.73%; Post-: 90.15 ± 1.66%; P = 0.010) compared to Pre-Fe+DHA/EPA offspring. Female Post-Fe+DHA/EPA offspring also had significantly lower liver iron concentrations compared to female Pre-Fe+DHA/EPA offspring (Pre-: 537 ± 47.13 μg/L vs Post-: 310 ± 45.28 μg/L; P = 0.034). There were no other significant differences in monoamine concentrations or behavioural tests.Our results indicate that supplementing ID and n-3 FAD mothers both before and after conception is efficacious in preventing neurodevelopmental deficits associated with deficiency. However, ID and n-3 FAD during the periconceptional period may alter reward-based learning in female offspring&lt;jats:sup&gt;(9-11)&lt;/jats:sup&gt;. Additionally, optimising iron provision during periconception may have important implications for the prevention of p","PeriodicalId":20751,"journal":{"name":"Proceedings of the Nutrition Society","volume":"23 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141527178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and associations between micronutrient deficiencies and growth indicators of 10-18-year-old female adolescents living in Vietnam 越南 10-18 岁女性青少年微量营养素缺乏症的患病率及其与发育指标之间的关系
IF 7 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-07-03 DOI: 10.1017/s002966512400452x
X. Tan, P.Y Tan, V. Som, S. Nguyen, D.T Tran, T.N Tran, V.K Tran, Y.Y Gong, J. B. Moore
Although in recent decades progress has been made in reducing the global burden of micronutrient deficiencies (MNDs), nonetheless MNDs prevalence remains high in some populations<jats:sup>(1)</jats:sup>. Among the micronutrients, deficiencies in iron, zinc and vitamin A are particularly prevalent, and causally associated with adverse health outcomes for children and adolescents. The aim of this study was to examine the prevalence and associations between MNDs and components of the double burden of malnutrition in female adolescents utilizing the nationally representative Vietnam General Nutrition Survey 2020.1,471 female adolescents were included and categorised into: pre-adolescent (10-12-year-old), middle-adolescent (13-15-year-old), and late-adolescent (16-18-year-old) groups. Biomarkers of micronutrients, anthropometry, and sociodemographic data were selected for analyses. WHO growth reference values were applied to define stunting (height-for-age z-score (HAZ) < −2 SD), thinness (BMI-for-age z-score (BAZ) < −2 SD) and overweight (BAZ > 1). Iron deficiency was defined as serum ferritin<15μg/L (<70 μg/L for individuals with inflammation), vitamin A insufficiency (VAI) as serum retinol<1.05 μmol/L, zinc deficiency was based on Zinc International Consultative Group Recommendation, and inflammation as C-reactive protein >5 mg/L or α1-acid glycoprotein >1 g/L. One or multiple MNDs were defined as individuals with ≥ 1 MNDs.Data were analysed by STATA 17 (STATA Corporation, US). Descriptive and logistic regression analyses were performed based on the sampling weight adjustments for the estimation at population level. Multivariate logistic regressions between MNDs and growth indicators were presented as crude (COR) and 95% confidence intervals or adjusted odds ratio (AOR), after adjusting for sociodemographic variables (age, ecological area, demographic, ethnicity, and wealth index) and inflammation.Compared to the pre-adolescent group, prevalence of stunting doubled in late adolescence (12.4% to 26.8%). Meanwhile, the prevalence of overweight and thinness decreased with age (29.7% to 22.0% and 9.4% to 2.7%, respectively). Overall, the prevalence of MNDs increased with age. Zinc deficiency occurred most often in the entire cohort (39.8% in 10-18) and contributed the most to multi-MNDs. Prevalence of one or multiple MNDs increased with age, from 58.1% in pre-adolescence to 80% in late adolescence. In logistic regression analyses adjusting for inflammation and sociodemographic factors, stunting increased the risk of having ≥1 MNDs (AOR: 1.94 (1.3, 2.88), p=0.002), but not individual MND alone. Thinness increased the risk of VAI (AOR: 2.38 (1.34, 4.22), p=0.005). No association was found between any MND and overweight, although overweight was protective against zinc deficiency (COR: 0.76 (0.59, 0.99), p=0.04) in the unadjusted model.Female late adolescents in Vietnam had a higher prevalence of stunting and MNDs, but lower prevale
尽管近几十年来在减轻全球微量营养素缺乏症(MNDs)负担方面取得了进展,但在一些人群中,微量营养素缺乏症的发病率仍然很高(1)。在微量营养素中,铁、锌和维生素 A 的缺乏尤为普遍,而且与儿童和青少年的不良健康后果有因果关系。这项研究的目的是利用具有全国代表性的《2020 年越南营养状况普查》(Vietnam General Nutrition Survey 2020),研究女性青少年中多营养素缺乏症(MNDs)的患病率及其与营养不良双重负担之间的关联。研究人员选取了微量营养素生物标志物、人体测量和社会人口学数据进行分析。采用世界卫生组织的生长参考值来定义发育迟缓(身高-年龄 z 值 (HAZ) < -2 SD)、消瘦(体重指数-年龄 z 值 (BAZ) < -2 SD)和超重(体重指数-年龄 z 值 (BAZ) >1)。铁缺乏的定义是血清铁蛋白<15μg/L(有炎症者为 70 μg/L),维生素 A 不足(VAI)的定义是血清视黄醇<1.05 μmol/L,锌缺乏的定义基于锌国际咨询小组的建议,炎症的定义是 C 反应蛋白>5 mg/L 或 α1-酸性糖蛋白>1 g/L。数据由 STATA 17(美国 STATA 公司)分析。根据抽样权重调整进行描述性分析和逻辑回归分析,以估计人群水平。在对社会人口变量(年龄、生态区、人口、种族和财富指数)和炎症进行调整后,MNDs 与生长指标之间的多变量逻辑回归结果以粗略值(COR)和 95% 置信区间或调整后的几率比(AOR)表示。同时,超重和消瘦的发生率随着年龄的增长而下降(分别从 29.7% 降至 22.0%,从 9.4% 降至 2.7%)。总体而言,MND 的患病率随着年龄的增长而增加。缺锌在整个人群中发生率最高(10-18 岁人群中占 39.8%),也是导致多种多发性硬化症的主要原因。一种或多种 MND 的患病率随着年龄的增长而增加,从青春期前的 58.1% 增加到青春期后期的 80%。在对炎症和社会人口因素进行调整的逻辑回归分析中,发育迟缓会增加≥1种MND的患病风险(AOR:1.94 (1.3, 2.88),p=0.002),但不会单独增加单种MND的患病风险。消瘦会增加罹患 VAI 的风险(AOR:2.38 (1.34, 4.22),p=0.005)。尽管在未调整模型中,超重对缺锌具有保护作用(COR:0.76 (0.59, 0.99),p=0.04),但没有发现任何 MND 与超重之间存在关联。与青少年前期相比,越南女性晚期青少年发育迟缓和 MND 的发病率较高,但瘦弱和超重的发病率较低。发育迟缓是与患有一种或多种 MNDs 相关的风险因素。瘦弱与较高的 VAI 风险有关。在这组人群中,没有发现超重与多发性神经营养不良之间有任何关联。
{"title":"Prevalence and associations between micronutrient deficiencies and growth indicators of 10-18-year-old female adolescents living in Vietnam","authors":"X. Tan, P.Y Tan, V. Som, S. Nguyen, D.T Tran, T.N Tran, V.K Tran, Y.Y Gong, J. B. Moore","doi":"10.1017/s002966512400452x","DOIUrl":"https://doi.org/10.1017/s002966512400452x","url":null,"abstract":"Although in recent decades progress has been made in reducing the global burden of micronutrient deficiencies (MNDs), nonetheless MNDs prevalence remains high in some populations&lt;jats:sup&gt;(1)&lt;/jats:sup&gt;. Among the micronutrients, deficiencies in iron, zinc and vitamin A are particularly prevalent, and causally associated with adverse health outcomes for children and adolescents. The aim of this study was to examine the prevalence and associations between MNDs and components of the double burden of malnutrition in female adolescents utilizing the nationally representative Vietnam General Nutrition Survey 2020.1,471 female adolescents were included and categorised into: pre-adolescent (10-12-year-old), middle-adolescent (13-15-year-old), and late-adolescent (16-18-year-old) groups. Biomarkers of micronutrients, anthropometry, and sociodemographic data were selected for analyses. WHO growth reference values were applied to define stunting (height-for-age z-score (HAZ) &lt; −2 SD), thinness (BMI-for-age z-score (BAZ) &lt; −2 SD) and overweight (BAZ &gt; 1). Iron deficiency was defined as serum ferritin&lt;15μg/L (&lt;70 μg/L for individuals with inflammation), vitamin A insufficiency (VAI) as serum retinol&lt;1.05 μmol/L, zinc deficiency was based on Zinc International Consultative Group Recommendation, and inflammation as C-reactive protein &gt;5 mg/L or α1-acid glycoprotein &gt;1 g/L. One or multiple MNDs were defined as individuals with ≥ 1 MNDs.Data were analysed by STATA 17 (STATA Corporation, US). Descriptive and logistic regression analyses were performed based on the sampling weight adjustments for the estimation at population level. Multivariate logistic regressions between MNDs and growth indicators were presented as crude (COR) and 95% confidence intervals or adjusted odds ratio (AOR), after adjusting for sociodemographic variables (age, ecological area, demographic, ethnicity, and wealth index) and inflammation.Compared to the pre-adolescent group, prevalence of stunting doubled in late adolescence (12.4% to 26.8%). Meanwhile, the prevalence of overweight and thinness decreased with age (29.7% to 22.0% and 9.4% to 2.7%, respectively). Overall, the prevalence of MNDs increased with age. Zinc deficiency occurred most often in the entire cohort (39.8% in 10-18) and contributed the most to multi-MNDs. Prevalence of one or multiple MNDs increased with age, from 58.1% in pre-adolescence to 80% in late adolescence. In logistic regression analyses adjusting for inflammation and sociodemographic factors, stunting increased the risk of having ≥1 MNDs (AOR: 1.94 (1.3, 2.88), p=0.002), but not individual MND alone. Thinness increased the risk of VAI (AOR: 2.38 (1.34, 4.22), p=0.005). No association was found between any MND and overweight, although overweight was protective against zinc deficiency (COR: 0.76 (0.59, 0.99), p=0.04) in the unadjusted model.Female late adolescents in Vietnam had a higher prevalence of stunting and MNDs, but lower prevale","PeriodicalId":20751,"journal":{"name":"Proceedings of the Nutrition Society","volume":"44 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141527217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are associations between adherence to the 2018 WCRF/AICR cancer prevention recommendations and risk of cancers modulated by multimorbidity? Findings from the UK Biobank prospective cohort study 2018年WCRF/AICR癌症预防建议的遵守情况与癌症风险之间的关系是否受多病情况的影响?英国生物库前瞻性队列研究结果
IF 7 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-07-03 DOI: 10.1017/s0029665124004506
F.C Malcomson, S. Parra-Soto, F. K Ho, L. Lu, C. Celis- Morales, L. Sharp, J. C Mathers
Approximately 40% of cancers in the UK are attributable to modifiable, lifestyle risk factors such as overweight and obesity and low dietary fibre intake(1). The WCRF and AICR published ten lifestyle- based Cancer Prevention Recommendations with the aim of reducing the risk of cancer and other non-communicable diseases(2). In the UK Biobank cohort, we have found reduced risk of cancer overall and of breast and colorectal cancers with greater adherence to these Cancer Prevention Recommendations (i.e., healthier lifestyles). The present study aimed to investigate whether the magnitude of these associations is modified by the presence of co-morbidities, such as diabetes and cardiovascular disease, at baseline.We used data from 94,778 participants (53% female, mean age 56 years) from the UK Biobank prospective cohort study, recruited between 2006 and 2010 and free from cancer at baseline. Adherence to the 2018 WCRF/AICR Cancer Prevention Recommendations was calculated from dietary, physical activity, and body composition data using a standardised score(3). Multimorbidity (list of 43 chronic diseases) was self-reported at baseline and categorised into: 0, 1, 2, or 3+ chronic illnesses. Incident cancer cases were identified using population-based cancer registries available until July 2019 for England and Wales and October 2015 for Scotland. Participants were categorised into approximate score tertiles, and the lowest tertile (lowest adherence, 0-3.5 points) was used as the reference category. Cox proportional hazard models were used to investigate associations between total score and incidence of cancer, adjusting for confounders, and to test for an interaction between total score and multimorbidity.55,191 (58%) participants had one chronic illness at baseline and 8,430 (9%) had ≥3. Mean total 2018 WCRF/AICR score was 3.8 (SD 1.0) points, and participants with the presence of chronic illnesses had a significantly lower total score (mean for ≥3 illnesses = 3.58 points vs 3.96 points for participants without chronic illness, p<0.001). During a median follow-up of 8 years, 3,303 individuals developed cancer. When investigating associations between score tertiles and the risk of cancer overall, there was a significant interaction between the total score and multimorbidity (HR for interaction: 1.59, p=0.002). There was also evidence for an interaction between total score and multimorbidity with breast cancer risk (HR for interaction: 1.23, p=0.030), but no evidence of an interaction between total score and multimorbidity for risk of colorectal cancer.We found stronger associations between total adherence score and the risk of cancer in participants with ≥3 chronic illnesses. This suggests that the chemoprotective effects of greater adherence to the 2018 WCRF/AICR Cancer Prevention Recommendations may be particularly beneficial for individuals with multimorbidity.
在英国,约 40% 的癌症可归因于可改变的生活方式风险因素,如超重、肥胖和低膳食纤维摄入量(1)。世界癌症研究基金会(WCRF)和美国癌症研究协会(AICR)发布了十项基于生活方式的癌症预防建议,旨在降低癌症和其他非传染性疾病的发病风险(2)。在英国生物库队列中,我们发现,更严格遵守这些防癌建议(即更健康的生活方式)可降低总体癌症风险以及乳腺癌和结直肠癌风险。本研究旨在调查这些关联的程度是否会因基线时存在糖尿病和心血管疾病等并发症而有所改变。我们使用了英国生物库前瞻性队列研究中94778名参与者(53%为女性,平均年龄56岁)的数据,这些参与者在2006年至2010年间被招募,基线时未患癌症。根据饮食、体力活动和身体成分数据,采用标准化评分(3)计算出2018年WCRF/AICR癌症预防建议的遵守情况。多病症(43 种慢性病清单)在基线时进行自我报告,并分为 0、1、2 或 3 类:0、1、2 或 3+ 种慢性病。英格兰和威尔士的癌症发病病例通过截至 2019 年 7 月的人口癌症登记处进行确认,苏格兰的癌症发病病例通过截至 2015 年 10 月的人口癌症登记处进行确认。参与者被分为近似分数三等分,最低的三等分(最低依从性,0-3.5 分)作为参考类别。在调整混杂因素后,采用 Cox 比例危险模型研究总分与癌症发病率之间的关系,并检验总分与多病之间的交互作用。55,191 名参与者(58%)在基线时患有一种慢性病,8,430 名参与者(9%)患有≥3 种慢性病。2018年WCRF/AICR平均总分为3.8分(SD 1.0),存在慢性疾病的参与者总分明显较低(≥3种疾病的参与者平均分为3.58分,无慢性疾病的参与者平均分为3.96分,P<0.001)。在中位 8 年的随访期间,有 3303 人罹患癌症。在调查总分与癌症风险之间的关系时,总分与多病症之间存在显著的交互作用(交互作用的 HR:1.59,p=0.002)。还有证据表明,总分和多病症与乳腺癌风险之间存在交互作用(交互作用 HR:1.23,p=0.030),但没有证据表明总分和多病症与结直肠癌风险之间存在交互作用。这表明,更严格遵守2018年WCRF/AICR癌症预防建议的化学保护作用可能对患有多种疾病的人特别有益。
{"title":"Are associations between adherence to the 2018 WCRF/AICR cancer prevention recommendations and risk of cancers modulated by multimorbidity? Findings from the UK Biobank prospective cohort study","authors":"F.C Malcomson, S. Parra-Soto, F. K Ho, L. Lu, C. Celis- Morales, L. Sharp, J. C Mathers","doi":"10.1017/s0029665124004506","DOIUrl":"https://doi.org/10.1017/s0029665124004506","url":null,"abstract":"Approximately 40% of cancers in the UK are attributable to modifiable, lifestyle risk factors such as overweight and obesity and low dietary fibre intake<jats:sup>(1)</jats:sup>. The WCRF and AICR published ten lifestyle- based Cancer Prevention Recommendations with the aim of reducing the risk of cancer and other non-communicable diseases<jats:sup>(2)</jats:sup>. In the UK Biobank cohort, we have found reduced risk of cancer overall and of breast and colorectal cancers with greater adherence to these Cancer Prevention Recommendations (i.e., healthier lifestyles). The present study aimed to investigate whether the magnitude of these associations is modified by the presence of co-morbidities, such as diabetes and cardiovascular disease, at baseline.We used data from 94,778 participants (53% female, mean age 56 years) from the UK Biobank prospective cohort study, recruited between 2006 and 2010 and free from cancer at baseline. Adherence to the 2018 WCRF/AICR Cancer Prevention Recommendations was calculated from dietary, physical activity, and body composition data using a standardised score<jats:sup>(3)</jats:sup>. Multimorbidity (list of 43 chronic diseases) was self-reported at baseline and categorised into: 0, 1, 2, or 3+ chronic illnesses. Incident cancer cases were identified using population-based cancer registries available until July 2019 for England and Wales and October 2015 for Scotland. Participants were categorised into approximate score tertiles, and the lowest tertile (lowest adherence, 0-3.5 points) was used as the reference category. Cox proportional hazard models were used to investigate associations between total score and incidence of cancer, adjusting for confounders, and to test for an interaction between total score and multimorbidity.55,191 (58%) participants had one chronic illness at baseline and 8,430 (9%) had ≥3. Mean total 2018 WCRF/AICR score was 3.8 (SD 1.0) points, and participants with the presence of chronic illnesses had a significantly lower total score (mean for ≥3 illnesses = 3.58 points vs 3.96 points for participants without chronic illness, p&lt;0.001). During a median follow-up of 8 years, 3,303 individuals developed cancer. When investigating associations between score tertiles and the risk of cancer overall, there was a significant interaction between the total score and multimorbidity (HR for interaction: 1.59, p=0.002). There was also evidence for an interaction between total score and multimorbidity with breast cancer risk (HR for interaction: 1.23, p=0.030), but no evidence of an interaction between total score and multimorbidity for risk of colorectal cancer.We found stronger associations between total adherence score and the risk of cancer in participants with ≥3 chronic illnesses. This suggests that the chemoprotective effects of greater adherence to the 2018 WCRF/AICR Cancer Prevention Recommendations may be particularly beneficial for individuals with multimorbidity.","PeriodicalId":20751,"journal":{"name":"Proceedings of the Nutrition Society","volume":"20 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141532714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The health impact of substituting meat with plant-based meat alternatives: findings from a Systematic Review 用植物性肉类替代品替代肉类对健康的影响:系统综述的结论
IF 7 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-07-03 DOI: 10.1017/s0029665124004373
L. Lindberg, R. Reid-McCann, J. Woodside, A. Nugent
<p>Sales of plant-based meat alternatives (PBMAs) are increasing<span>(1)</span>. While these products are becoming more popular, little is known about their impact on health<span>(2)</span>. Therefore, the aim of this work was to systematically review the evidence on PBMA consumption and associated health outcomes.</p><p>A wider systematic review looking at the environmental impact, ingredient composition, nutritional impact and health outcomes associated with PBMAs was conducted. A search strategy combined terms “meat alternatives” AND “environment” OR “ingredients” OR “nutrition” OR “health.” Five databases were searched, MEDLINE, EMBASE, Web of Science, Scopus and Greenfile, as well as reference lists of relevant articles. All study designs reporting primary data were included, except for animal studies and <span>in vitro</span> studies. Non-English studies and studies published before 2011 were excluded (PROSPERO Registration Number: CRD42021250541).</p><p>2184 papers were identified, 1802 papers remained after duplicates were removed, 1536 were excluded at title and abstract screen stage, 266 full texts were assessed for eligibility and 54 papers were included in the analysis for all outcomes investigated. Ten studies examined the impact of PBMA vs. meat consumption on health outcomes. Three studies measured postprandial response to single test meals<span>(3–5)</span>, four studies were longer-term RCTs<span>(6–8)</span> with two further separate publications reporting on different outcomes for the same RCT<span>(9,10)</span>. One study was a prospective cohort<span>(11)</span> and one a cross-sectional study<span>(12).</span></p><p>Of the single test meal studies, no significant differences were observed for glucose levels in 2/2 studies (100%)<span>(3,5)</span>, PYY and GLP-1 levels in 2/2 studies (100%)<span>(3,4)</span> and self-reported hunger/fullness in 3/3 studies (100%)<span>(3–5)</span>. Significantly lower insulin concentrations and subsequent energy intakes were both reported in 1/2 studies (50%) following consumption of mycoprotein vs. chicken meals<span>(3)</span>.</p><p>Longer-term full and partial replacement of meat with PBMAs resulted in significantly lower body weight (kg) in 2/2 studies (100%)<span>(6,10)</span>, significantly lower saturated fat intakes in 2/2 studies (100%) <span>(6,10)</span>, significantly higher fibre intakes in 2/3 studies (67%)<span>(6,7)</span>, improvements in plasma lipid profile in 2/3 studies (67%)<span>(7,10)</span> and positive changes in gut microbiota in 1/2 studies (50%)<span>(8)</span> compared to meat diet phases/control groups with no restrictions on meat intakes. There were no significant differences in protein intakes in 3/3 studies (100%)<span>(6,7,10)</span>, energy, total fat and carbohydrate intakes in 2/2 studies (100%) <span>(6,7)</span>, blood pressure in 2/2 studies (100%)<span>(6,10)</span>, glucose levels in 2/2 studies (100%) <span>(7,10)</span> and insulin levels in 2/2
植物基肉类替代品(PBMAs)的销量正在不断增长(1)。虽然这些产品越来越受欢迎,但人们对其对健康的影响却知之甚少(2)。因此,这项工作的目的是系统地回顾有关植物基肉类替代品消费和相关健康结果的证据。检索策略综合了 "肉类替代品"、"环境 "或 "成分 "或 "营养 "或 "健康 "等术语。检索了五个数据库:MEDLINE、EMBASE、Web of Science、Scopus 和 Greenfile,以及相关文章的参考文献列表。除动物研究和体外研究外,所有报告主要数据的研究设计均被纳入。共识别出 2184 篇论文,去除重复论文后剩余 1802 篇,在标题和摘要筛选阶段排除了 1536 篇,对 266 篇论文全文进行了资格评估,54 篇论文被纳入所有研究结果的分析中。有 10 项研究探讨了 PBMA 与肉类消费对健康结果的影响。三项研究测量了单次试验餐的餐后反应(3-5),四项研究为长期 RCT(6-8),另有两篇论文报告了同一 RCT 的不同结果(9,10)。一项研究是前瞻性队列研究(11),一项是横断面研究(12)。在单次试验餐研究中,2/2 项研究(100%)(3,5)的血糖水平、2/2 项研究(100%)(3,4) 的PYY 和 GLP-1 水平以及 3/3 项研究(100%)(3-5) 的自我报告的饥饿感/饱腹感均未观察到显著差异。有 1/2 项研究(50%)报告称,食用霉菌蛋白与鸡肉餐后,胰岛素浓度和随后的能量摄入量均显著降低(3)。与不限制肉类摄入量的肉类饮食阶段/对照组相比,长期用 PBMAs 完全或部分替代肉类的 2/2 项研究(100%)(6,10) 表明体重(公斤)明显降低,2/2 项研究(100%)(6,10) 表明饱和脂肪摄入量明显降低,2/3 项研究(67%)(6,7) 表明纤维摄入量明显增加,2/3 项研究(67%)(7,10) 表明血浆脂质状况有所改善,1/2 项研究(50%)(8) 表明肠道微生物群发生了积极变化。3/3 项研究(100%)(6,7,10)中的蛋白质摄入量、2/2 项研究(100%)(6,7)中的能量、总脂肪和碳水化合物摄入量、2/2 项研究(100%)(6,10)中的血压、2/2 项研究(100%)(7,10)中的葡萄糖水平和 2/2 项研究(100%)(7,10)中的胰岛素水平均无明显差异。由于研究数量较少,且研究设计、测量结果和使用的 PBMA 类型各不相同,因此无法就 PBMA 对健康结果的影响得出明确结论。从现有的有限证据来看,食用 PBMA 不会对健康产生负面影响,但需要进一步的长期 RCT 研究来证实这一点。
{"title":"The health impact of substituting meat with plant-based meat alternatives: findings from a Systematic Review","authors":"L. Lindberg, R. Reid-McCann, J. Woodside, A. Nugent","doi":"10.1017/s0029665124004373","DOIUrl":"https://doi.org/10.1017/s0029665124004373","url":null,"abstract":"&lt;p&gt;Sales of plant-based meat alternatives (PBMAs) are increasing&lt;span&gt;(1)&lt;/span&gt;. While these products are becoming more popular, little is known about their impact on health&lt;span&gt;(2)&lt;/span&gt;. Therefore, the aim of this work was to systematically review the evidence on PBMA consumption and associated health outcomes.&lt;/p&gt;&lt;p&gt;A wider systematic review looking at the environmental impact, ingredient composition, nutritional impact and health outcomes associated with PBMAs was conducted. A search strategy combined terms “meat alternatives” AND “environment” OR “ingredients” OR “nutrition” OR “health.” Five databases were searched, MEDLINE, EMBASE, Web of Science, Scopus and Greenfile, as well as reference lists of relevant articles. All study designs reporting primary data were included, except for animal studies and &lt;span&gt;in vitro&lt;/span&gt; studies. Non-English studies and studies published before 2011 were excluded (PROSPERO Registration Number: CRD42021250541).&lt;/p&gt;&lt;p&gt;2184 papers were identified, 1802 papers remained after duplicates were removed, 1536 were excluded at title and abstract screen stage, 266 full texts were assessed for eligibility and 54 papers were included in the analysis for all outcomes investigated. Ten studies examined the impact of PBMA vs. meat consumption on health outcomes. Three studies measured postprandial response to single test meals&lt;span&gt;(3–5)&lt;/span&gt;, four studies were longer-term RCTs&lt;span&gt;(6–8)&lt;/span&gt; with two further separate publications reporting on different outcomes for the same RCT&lt;span&gt;(9,10)&lt;/span&gt;. One study was a prospective cohort&lt;span&gt;(11)&lt;/span&gt; and one a cross-sectional study&lt;span&gt;(12).&lt;/span&gt;&lt;/p&gt;&lt;p&gt;Of the single test meal studies, no significant differences were observed for glucose levels in 2/2 studies (100%)&lt;span&gt;(3,5)&lt;/span&gt;, PYY and GLP-1 levels in 2/2 studies (100%)&lt;span&gt;(3,4)&lt;/span&gt; and self-reported hunger/fullness in 3/3 studies (100%)&lt;span&gt;(3–5)&lt;/span&gt;. Significantly lower insulin concentrations and subsequent energy intakes were both reported in 1/2 studies (50%) following consumption of mycoprotein vs. chicken meals&lt;span&gt;(3)&lt;/span&gt;.&lt;/p&gt;&lt;p&gt;Longer-term full and partial replacement of meat with PBMAs resulted in significantly lower body weight (kg) in 2/2 studies (100%)&lt;span&gt;(6,10)&lt;/span&gt;, significantly lower saturated fat intakes in 2/2 studies (100%) &lt;span&gt;(6,10)&lt;/span&gt;, significantly higher fibre intakes in 2/3 studies (67%)&lt;span&gt;(6,7)&lt;/span&gt;, improvements in plasma lipid profile in 2/3 studies (67%)&lt;span&gt;(7,10)&lt;/span&gt; and positive changes in gut microbiota in 1/2 studies (50%)&lt;span&gt;(8)&lt;/span&gt; compared to meat diet phases/control groups with no restrictions on meat intakes. There were no significant differences in protein intakes in 3/3 studies (100%)&lt;span&gt;(6,7,10)&lt;/span&gt;, energy, total fat and carbohydrate intakes in 2/2 studies (100%) &lt;span&gt;(6,7)&lt;/span&gt;, blood pressure in 2/2 studies (100%)&lt;span&gt;(6,10)&lt;/span&gt;, glucose levels in 2/2 studies (100%) &lt;span&gt;(7,10)&lt;/span&gt; and insulin levels in 2/2 ","PeriodicalId":20751,"journal":{"name":"Proceedings of the Nutrition Society","volume":"59 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141496189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex and gender in sports nutrition research: bridging the gap. 运动营养研究中的性别与社会性别问题:缩小差距。
IF 7.6 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-07-01 DOI: 10.1017/S002966512400466X
Sharon M Madigan

The Olympic Games have grown to be the largest, gender-equal sporting event in the world, and the International Olympic Committee is committed to gender equality in sports encouraging and supporting the promotion of women in sports at all levels and in all structures with a view to implementing the principle of equality of men and women (IOC, 2023). Women competed for the first time at the 1900 Olympic Games in Paris, and the number of women competing has grown exponentially over the last 100 years, so an estimated 5494 female athletes (48 %) competed in the Summer Olympic Games 2021 in Tokyo. Supporting women (alongside men) in achieving optimum performance is crucial, and understanding that there are sex and gender gaps in sports nutrition research is important. One reason for this gap is the historical bias in sports and exercise science research towards male participants. This has led to a poor understanding of the unique physiological and nutritional needs of female athletes. In summary, a balanced approach is crucial to address the nutritional needs of both male and female athletes. Researchers should continue exploring this important area to optimise performance and health for all athletes. The aim of this review is to summarise current sports nutrition literature and highlight research that seeks to understand and address where the gaps are with respect to several key areas in sports nutrition recommendations that can impact advice and practice with both males and females.

奥运会已发展成为世界上规模最大、性别平等的体育赛事,国际奥委会致力于在体育运动中实现性别平等,鼓励和支持在所有级别和所有结构中促进妇女参与体育运动,以落实男女平等原则(国际奥委会,2023 年)。在 1900 年巴黎奥运会上,女性首次参加了比赛,在过去的 100 年里,女性参赛人数成倍增长,估计有 5494 名女运动员(48%)参加了 2021 年东京夏季奥运会。支持女性(与男性一起)实现最佳表现至关重要,了解运动营养研究中存在的性别差距也很重要。造成这种差距的原因之一是体育和运动科学研究历来偏重男性参与者。这导致人们对女性运动员独特的生理和营养需求缺乏了解。总之,平衡的方法对于满足男女运动员的营养需求至关重要。研究人员应继续探索这一重要领域,以优化所有运动员的表现和健康。本综述旨在总结当前的运动营养文献,并重点介绍旨在了解和解决运动营养建议中几个关键领域存在的差距的研究,这些领域可能会影响对男性和女性运动员的建议和实践。
{"title":"Sex and gender in sports nutrition research: bridging the gap.","authors":"Sharon M Madigan","doi":"10.1017/S002966512400466X","DOIUrl":"10.1017/S002966512400466X","url":null,"abstract":"<p><p>The Olympic Games have grown to be the largest, gender-equal sporting event in the world, and the International Olympic Committee is committed to gender equality in sports encouraging and supporting the promotion of women in sports at all levels and in all structures with a view to implementing the principle of equality of men and women (IOC, 2023). Women competed for the first time at the 1900 Olympic Games in Paris, and the number of women competing has grown exponentially over the last 100 years, so an estimated 5494 female athletes (48 %) competed in the Summer Olympic Games 2021 in Tokyo. Supporting women (alongside men) in achieving optimum performance is crucial, and understanding that there are sex and gender gaps in sports nutrition research is important. One reason for this gap is the historical bias in sports and exercise science research towards male participants. This has led to a poor understanding of the unique physiological and nutritional needs of female athletes. In summary, a balanced approach is crucial to address the nutritional needs of both male and female athletes. Researchers should continue exploring this important area to optimise performance and health for all athletes. The aim of this review is to summarise current sports nutrition literature and highlight research that seeks to understand and address where the gaps are with respect to several key areas in sports nutrition recommendations that can impact advice and practice with both males and females.</p>","PeriodicalId":20751,"journal":{"name":"Proceedings of the Nutrition Society","volume":" ","pages":"1-7"},"PeriodicalIF":7.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Managing malnutrition and multimorbidity in primary care: dietary approaches to reduce treatment burden. 初级保健中的营养不良和多病管理:减轻治疗负担的饮食方法。
IF 7.6 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-05-16 DOI: 10.1017/S0029665124004695
Rebecca J Stratton

There are many health and nutrition implications of suffering from multimorbidity, which is a huge challenge facing health and social services. This review focuses on malnutrition, one of the nutritional consequences of multimorbidity. Malnutrition can result from the impact of chronic conditions and their management (polypharmacy) on appetite and nutritional intake, leading to an inability to meet nutritional requirements from food. Malnutrition (undernutrition) is prevalent in primary care and costly, the main cause being disease, accentuated by multiple morbidities. Most of the costs arise from the deleterious effects of malnutrition on individual's function, clinical outcome and recovery leading to a substantially greater burden on treatment and health care resources, costing at least £19·6 billion in England. Routine identification of malnutrition with screening should be part of the management of multimorbidity together with practical, effective ways of treating malnutrition that overcome anorexia where relevant. Nutritional interventions that improve nutritional intake have been shown to significantly reduce mortality in individuals with multimorbidities. In addition to food-based interventions, a more 'medicalised' dietary approach using liquid oral nutritional supplements (ONS) can be effective. ONS typically have little impact on appetite, effectively improve energy, protein and micronutrient intakes and may significantly improve functional measures. Reduced treatment burden can result from effective nutritional intervention with improved clinical outcomes (fewer infections, wounds), reducing health care use and costs. With the right investment in nutrition and dietetic resources, appropriate nutritional management plans can be put in place to optimally support the multimorbid patient benefitting the individual and the wider society.

多病并发症对健康和营养有很多影响,是医疗和社会服务面临的巨大挑战。本综述的重点是营养不良,这是多病共存的营养后果之一。营养不良可能是由于慢性病及其管理(多药并用)对食欲和营养摄入的影响,导致无法从食物中获得所需的营养。营养不良(营养不足)在初级保健中很普遍,而且代价高昂,主要原因是疾病,而多种疾病又加剧了营养不良。大部分费用来自营养不良对个人功能、临床结果和康复的有害影响,导致治疗和医疗资源负担大大增加,在英格兰至少花费 196 亿英镑。通过筛查对营养不良进行常规识别应成为多病管理的一部分,同时还应采取切实有效的方法治疗营养不良,以克服厌食症。事实证明,改善营养摄入的营养干预措施可显著降低多病患者的死亡率。除了以食物为基础的干预措施外,使用液体口服营养补充剂(ONS)这种更加 "医学化 "的饮食方法也很有效。口服营养补充剂通常对食欲影响不大,能有效改善能量、蛋白质和微量元素的摄入,并能显著改善功能指标。有效的营养干预可以减轻治疗负担,改善临床效果(减少感染和伤口),减少医疗服务的使用和成本。通过对营养和营养学资源的正确投资,可以制定适当的营养管理计划,为多病病人提供最佳支持,使个人和整个社会受益。
{"title":"Managing malnutrition and multimorbidity in primary care: dietary approaches to reduce treatment burden.","authors":"Rebecca J Stratton","doi":"10.1017/S0029665124004695","DOIUrl":"10.1017/S0029665124004695","url":null,"abstract":"<p><p>There are many health and nutrition implications of suffering from multimorbidity, which is a huge challenge facing health and social services. This review focuses on malnutrition, one of the nutritional consequences of multimorbidity. Malnutrition can result from the impact of chronic conditions and their management (polypharmacy) on appetite and nutritional intake, leading to an inability to meet nutritional requirements from food. Malnutrition (undernutrition) is prevalent in primary care and costly, the main cause being disease, accentuated by multiple morbidities. Most of the costs arise from the deleterious effects of malnutrition on individual's function, clinical outcome and recovery leading to a substantially greater burden on treatment and health care resources, costing at least £19·6 billion in England. Routine identification of malnutrition with screening should be part of the management of multimorbidity together with practical, effective ways of treating malnutrition that overcome anorexia where relevant. Nutritional interventions that improve nutritional intake have been shown to significantly reduce mortality in individuals with multimorbidities. In addition to food-based interventions, a more 'medicalised' dietary approach using liquid oral nutritional supplements (ONS) can be effective. ONS typically have little impact on appetite, effectively improve energy, protein and micronutrient intakes and may significantly improve functional measures. Reduced treatment burden can result from effective nutritional intervention with improved clinical outcomes (fewer infections, wounds), reducing health care use and costs. With the right investment in nutrition and dietetic resources, appropriate nutritional management plans can be put in place to optimally support the multimorbid patient benefitting the individual and the wider society.</p>","PeriodicalId":20751,"journal":{"name":"Proceedings of the Nutrition Society","volume":" ","pages":"1-9"},"PeriodicalIF":7.6,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140945717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral health and multimorbidity: is diet the chicken or the egg? 口腔健康与多病症:饮食是鸡还是蛋?
IF 7 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-05-14 DOI: 10.1017/S0029665124004683
Teresa A Marshall, Riva Touger-Decker

Oral health is a critical component of overall health and well-being, not just the absence of disease. The objective of this review paper is to describe relationships among diet, nutrition and oral and systemic diseases that contribute to multimorbidity. Diet- and nutrient-related risk factors for oral diseases include high intakes of free sugars, low intakes of fruits and vegetables and nutrient-poor diets which are similar to diet- and nutrient-related risk factors for systemic diseases. Oral diseases are chronic diseases. Once the disease process is initiated, it persists throughout the lifespan. Pain and tissue loss from oral disease leads to oral dysfunction which contributes to impaired biting, chewing, oral motility and swallowing. Oral dysfunction makes it difficult to eat nutrient-dense whole grains, fruits and vegetables associated with a healthy diet. Early childhood caries (ECC) associated with frequent intake of free sugars is one of the first manifestations of oral disease. The presence of ECC is our 'canary in the coal mine' for diet-related chronic diseases. The dietary sugars causing ECC are not complementary to an Eatwell Guide compliant diet, but rather consistent with a diet high in energy-dense, nutrient-poor foods - typically ultra-processed in nature. This diet generally deteriorates throughout childhood, adolescence and adulthood increasing the risk of diet-related chronic diseases. Recognition of ECC is an opportunity to intervene and disrupt the pathway to multimorbidities. Disruption of this pathway will reduce the risk of multimorbidities and enable individuals to fully engage in society throughout the lifespan.

口腔健康是整体健康和幸福的重要组成部分,而不仅仅是没有疾病。本综述旨在描述饮食、营养、口腔和导致多发病的全身性疾病之间的关系。与膳食和营养相关的口腔疾病风险因素包括游离糖摄入量高、水果和蔬菜摄入量低以及膳食营养不良,这与与膳食和营养相关的全身性疾病风险因素相似。口腔疾病是一种慢性疾病。疾病过程一旦开始,就会持续一生。口腔疾病引起的疼痛和组织损失会导致口腔功能障碍,从而使咬合、咀嚼、口腔活动和吞咽功能受损。口腔功能障碍使人们很难吃到与健康饮食相关的营养丰富的全谷物、水果和蔬菜。与经常摄入游离糖有关的儿童早期龋齿(ECC)是口腔疾病的最初表现之一。儿童早期龋齿是与饮食有关的慢性疾病的 "煤矿金丝雀"。导致 ECC 的膳食糖与符合《饮食健康指南》的饮食习惯并不相辅相成,而是与高能量、低营养的饮食习惯相一致,这种饮食习惯通常是超加工食品。这种饮食习惯通常会在儿童期、青少年期和成年期不断恶化,从而增加罹患与饮食有关的慢性疾病的风险。认识到 ECC 是进行干预和阻断多种疾病发生途径的一个机会。阻断这一途径将降低罹患多种疾病的风险,使个人在整个生命周期中都能充分参与社会活动。
{"title":"Oral health and multimorbidity: is diet the chicken or the egg?","authors":"Teresa A Marshall, Riva Touger-Decker","doi":"10.1017/S0029665124004683","DOIUrl":"10.1017/S0029665124004683","url":null,"abstract":"<p><p>Oral health is a critical component of overall health and well-being, not just the absence of disease. The objective of this review paper is to describe relationships among diet, nutrition and oral and systemic diseases that contribute to multimorbidity. Diet- and nutrient-related risk factors for oral diseases include high intakes of free sugars, low intakes of fruits and vegetables and nutrient-poor diets which are similar to diet- and nutrient-related risk factors for systemic diseases. Oral diseases are chronic diseases. Once the disease process is initiated, it persists throughout the lifespan. Pain and tissue loss from oral disease leads to oral dysfunction which contributes to impaired biting, chewing, oral motility and swallowing. Oral dysfunction makes it difficult to eat nutrient-dense whole grains, fruits and vegetables associated with a healthy diet. Early childhood caries (ECC) associated with frequent intake of free sugars is one of the first manifestations of oral disease. The presence of ECC is our 'canary in the coal mine' for diet-related chronic diseases. The dietary sugars causing ECC are not complementary to an Eatwell Guide compliant diet, but rather consistent with a diet high in energy-dense, nutrient-poor foods - typically ultra-processed in nature. This diet generally deteriorates throughout childhood, adolescence and adulthood increasing the risk of diet-related chronic diseases. Recognition of ECC is an opportunity to intervene and disrupt the pathway to multimorbidities. Disruption of this pathway will reduce the risk of multimorbidities and enable individuals to fully engage in society throughout the lifespan.</p>","PeriodicalId":20751,"journal":{"name":"Proceedings of the Nutrition Society","volume":" ","pages":"1-8"},"PeriodicalIF":7.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140916283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Proceedings of the Nutrition Society
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1