Schizophrenia being a major psychiatric disorder comprises of dominant neurodevelopmental corroborations; still there are inadequate markers which reveal the brain vulnerability. Recognition of such neurodevelopmental correlates linked with schizophrenia is a major hindrance observed in today’s era. It presents itself as a major hurdle as it necessitates comprehending the early brain alterations hinting towards vulnerability of brain parenchyma towards disorders. One such correlate being cavum septum pellucidum (CSP), has been frequently linked with schizophrenia. The primary obstacle in the management of psychological disorders is the significantly delayed diagnosis because of the societal stigma and the preconceived notions about these diseases.
This narrative review encompasses recent studies from 2018–2025 extracting high yield neuroimaging, molecular, genetic data to meticulously explain the association between enlarged CSP and schizophrenia, to critically appraise the clinical potential of enlarged cavum septum pellucidum as a neurodevelopmental liability marker as well as for incorporating them with multimodal artificial intelligence models rather than predicting or diagnosing schizophrenia at patient level.
This review is first to amalgamate extensive volumetric, meta-analyses as well as genetic data to highlight the role of CSP as a correlation risk marker from other non-specific parameters, aiding in better management of patients.
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