Psychiatry Research: Neuroimaging最新文献_第7页

Complex post-traumatic stress disorder moderates functional connectivity in people with psychosis 复杂创伤后应激障碍调节精神病患者的功能连接

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Psychiatry Research: Neuroimaging

Pub Date : 2025-11-04 DOI: 10.1016/j.pscychresns.2025.112082

Peter Panayi , Filippo Varese , Emmanuelle Peters , Liam Mason , Richard Bentall , Amy Hardy , Katherine Berry , William Sellwood , Robert Dudley , Raphael Underwood , Craig Steel , Hassan Jafari , Rebecca Elliott

Background

Altered functional connectivity in several functional networks has been found in people with psychosis, especially in the default mode (DMN), salience (SAL) and central executive (CEN) networks. Functional connectivity in people with psychosis is influenced by traumatic life experiences. Trauma histories typical of people with psychosis are associated with complex post-traumatic stress disorder (cPTSD), but no studies have explored whether post-traumatic sequelae contribute to functional dysconnectivity in people with psychosis.

Methods

Using resting-state fMRI, we compared two groups meeting diagnostic criteria for schizophrenia spectrum disorders (N = 106); one group additionally met ICD-11 criteria for comorbid cPTSD, whereas the other did not. We assessed between-group differences in functional connectivity between 15 pre-defined regions of the DMN, SAL and CEN. Post-hoc correlations were used to test whether intra- and/or inter-network connectivity related to cPTSD symptom severity in the comorbid cPTSD group.

Results

The comorbid cPTSD group demonstrated significantly lower functional connectivity within the DMN, SAL and CEN, as well as increased negative connectivity between the SAL and CEN. The control group showed significantly decreased connectivity of the DMN with the SAL and CEN. PTSD symptoms correlated positively with intra-SAL connectivity and DMN-SAL dysconnectivity, whereas DSOs correlated positively with intra-SAL dysconnectivity and reduced DMN-CEN connectivity.

Conclusions

Our findings broadly align with the tripartite network model explaining psychopathology in terms of DMN, SAL and CEN dysconnectivity. Intra-network dysconnectivity in subgroups of people with psychosis may relate to post-traumatic sequelae, whereas inter-network dysconnectivity may be more central in trauma-unrelated psychoses.

在精神病患者中发现了几个功能网络的功能连通性，特别是在默认模式（DMN），突出性（SAL）和中央执行（CEN）网络中。精神病患者的功能连通性受到创伤性生活经历的影响。精神病患者的典型创伤史与复杂创伤后应激障碍（cPTSD）有关，但尚未有研究探讨创伤后后遗症是否会导致精神病患者的功能连接障碍。方法采用静息态功能磁共振（fMRI）技术，比较符合精神分裂症谱系障碍诊断标准的两组患者（106例）；其中一组还符合ICD-11对共病cPTSD的标准，而另一组则没有。我们评估了DMN、SAL和CEN的15个预定义区域之间功能连通性的组间差异。使用事后相关性来测试共病cPTSD组中网络内和/或网络间连通性是否与cPTSD症状严重程度相关。结果合并cPTSD组DMN、SAL和CEN之间的功能连通性明显降低，SAL和CEN之间的负连通性增加。对照组DMN与SAL和CEN的连通性明显下降。PTSD症状与sal内连通性和DMN-SAL连接障碍正相关，而dso与sal内连通性障碍和DMN-CEN连接减少正相关。结论sour的发现与从DMN、SAL和CEN连接障碍方面解释精神病理的三方网络模型基本一致。精神病患者亚群中的网络内连接障碍可能与创伤后后遗症有关，而网络间连接障碍可能在与创伤无关的精神病中更为重要。

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引用次数: 0

Volume of the amygdala, hippocampus, Heschl’s gyrus, and planum temporale in epileptic psychosis 癫痫性精神病的杏仁核、海马体、海马回和颞平面的体积

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Psychiatry Research: Neuroimaging

Pub Date : 2025-11-03 DOI: 10.1016/j.pscychresns.2025.112081

Noriaki Hirakawa , Naoya Oribe , Yoji Hirano , Osamu Togao , Kousei Ishigami , Toshiaki Onitsuka , Shogo Hirano , Tomohiro Nakao

Background

Schizophrenia and chronic interictal epileptic psychosis (EPS) are thought to have different underlying pathophysiological mechanisms. We aimed to investigate the neural basis of EPS.

Methods

T1-weighted images were analyzed in 16 patients with EPS, 16 strictly matched patients with epilepsy only (EP), and 16 healthy control subjects (HS). We conducted structural magnetic resonance imaging analyses using a manual drawing method of several regions of interest (ROIs): the amygdala, hippocampus, Heschl’s gyrus, and planum temporale.

Results

Results revealed that both the EP and EPS groups exhibited significantly lower hippocampal volumes than the HS group (p = 0.008). There were no significant differences in the volume of any ROI between the EP and EPS groups.

Conclusions

Our ROI analyses indicated that the hippocampus is affected by epilepsy but the amygdala, hippocampus, Heschl’s gyrus, and planum temporale may not be crucial for generating EPS.

精神分裂症和慢性间隔性癫痫性精神病（EPS）被认为具有不同的病理生理机制。我们的目的是探讨EPS的神经基础。方法分析16例EPS患者、16例严格匹配的单纯癫痫患者（EP）和16例健康对照（HS）的st1加权图像。我们使用手工绘制方法对几个感兴趣区域（roi）进行了结构磁共振成像分析：杏仁核、海马体、Heschl’s回和颞平面。结果EP组和EPS组海马体积均显著低于HS组（p = 0.008）。在EP组和EPS组之间，任何ROI的体积没有显着差异。结论sour ROI分析表明，癫痫对海马有影响，但杏仁核、海马、海马回和颞平面可能不是产生EPS的关键部位。

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引用次数: 0

Hierarchical network disruptions in Schizophrenia: A multi-level fMRI study of functional connectivity 精神分裂症的分层网络中断：功能连接的多层次fMRI研究

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Psychiatry Research: Neuroimaging

Pub Date : 2025-10-16 DOI: 10.1016/j.pscychresns.2025.112078

V.S. Khorev , S.A. Kurkin , D. Stoyanov , R. Paunova , D. Najar , S. Kandilarova , A.E. Hramov

Background:

We tested the hypothesis that Schizophrenia (SCZ) involves a systematic breakdown in brain network organization across different levels of graph-theoretical hierarchy.

Methods:

Using resting-state fMRI from 43 SCZ patients and 63 matched healthy controls, we implemented an analytical multi-level framework. This integrated: global graph theory metrics to assess overall network topology; macronetwork metrics to measure functional specialization of large-scale systems; network-based statistics (NBS) to identify specific, altered pathways at the local level; a multigraph model to visualize hub reorganization between networks.

Results:

We revealed a coherent pattern of multi-level dysfunction. Globally, SCZ networks showed increased local clustering and connection density, indicating a shift toward a less efficient, overly segregated architecture. At the macroscale, sensory and salience networks displayed elevated local connectivity, while higher-order cognitive networks (e.g., DMN, DAN) showed reduced specialization and increased cross-talk. Locally, NBS identified a core subnetwork of weakened connectivity within temporal-orbitofrontal-cingulate circuits. The multigraph model synthesized these findings, showing a widespread reduction in the integrative role of key cognitive hubs.

Conclusions:

Our findings establish a model of SCZ as a disorder of disintegrated brain network hierarchy, where disruptions at the level of local circuits and functional specializations collectively lead to global topological inefficiency.

背景：我们检验了一种假设，即精神分裂症（SCZ）涉及大脑网络组织在不同水平的图理论层次上的系统破坏。方法：利用43例SCZ患者和63例匹配的健康对照者的静息状态功能磁共振成像（fMRI），我们实施了一个多层次的分析框架。这集成：全局图论指标评估整体网络拓扑；度量大型系统功能专门化的宏观网络度量基于网络的统计（NBS），以确定地方层面的具体、改变的途径；网络间集线器重组可视化的多图模型。结果：我们揭示了多层次功能障碍的连贯模式。在全球范围内，SCZ网络显示出增加的本地集群和连接密度，表明向效率较低、过度隔离的架构转变。在宏观尺度上，感觉网络和显著性网络表现出增强的局部连通性，而高阶认知网络（如DMN、DAN）表现出专业化程度降低和串扰增加。在局部，NBS在颞眶额扣带电路中发现了一个连接减弱的核心子网络。多图模型综合了这些发现，显示了关键认知中枢的综合作用的广泛减少。结论：我们的研究结果建立了一个SCZ模型，认为它是一种脑网络分层解体的紊乱，其中局部电路和功能专门化水平的中断共同导致全局拓扑效率低下。

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引用次数: 0

Phenotypic fitting of whole-brain models to explore functional connectivity dynamics correlates of hallucinations in schizophrenia 全脑模型的表型拟合以探索精神分裂症幻觉的功能连接动力学相关

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Psychiatry Research: Neuroimaging

Pub Date : 2025-10-16 DOI: 10.1016/j.pscychresns.2025.112080

Szymon Tyras, Marcin Wojnar

The pathophysiology of schizophrenia and its associated symptoms remains poorly understood despite decades of research utilizing diverse neuroimaging techniques. Recent advancements, such as the analysis of dynamic functional connectivity in resting-state fMRI signals and the application of generative whole-brain models - computational psychiatry tool, offer novel insights into the disorder. In this exploratory study we applied a recently developed phenotypic fitting approach for whole-brain modeling to investigate functional connectivity dynamics correlates of schizophrenia symptoms. Our findings showed that higher hallucination severity was strongly correlated with functional connectivity dynamics resembling those generated by a dynamic mean field model operating with elevated excitation/inhibition balance.

尽管几十年来利用各种神经成像技术进行了研究，但对精神分裂症及其相关症状的病理生理学仍然知之甚少。最近的进展，如静息状态fMRI信号的动态功能连接分析和生成全脑模型-计算精神病学工具的应用，为这种疾病提供了新的见解。在这项探索性研究中，我们应用了最近开发的全脑建模的表型拟合方法来研究精神分裂症症状的功能连接动力学相关。我们的研究结果表明，较高的幻觉严重程度与功能连接动力学密切相关，类似于在兴奋/抑制平衡升高的动态平均场模型中产生的功能连接动力学。

引用次数: 0

Exploring the neural mechanisms of anomalous self-experiences in schizophrenia: A fresh perspective on discharge dysfunction 探索精神分裂症异常自我体验的神经机制：放电功能障碍的新视角。

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Psychiatry Research: Neuroimaging

Pub Date : 2025-10-15 DOI: 10.1016/j.pscychresns.2025.112079

Jing Zhang, Lu Hou

This commentary article delves into the study by M. Beño-Ruiz-de-la-Sierra et al., which investigates the role of corollary discharge dysfunction in anomalous self-experiences (ASEs) among schizophrenic patients. The study's findings, while insightful, prompt further exploration into the specific brain regions involved, the statistical methods employed, and the implications for different schizophrenia subtypes. This paper aims to supplement the discussion by suggesting areas for future research and methodological enhancements.

这篇评论文章深入研究了M. Beño-Ruiz-de-la-Sierra等人的研究，该研究调查了必然性放电功能障碍在精神分裂症患者异常自我体验（ASEs）中的作用。这项研究的发现虽然有深刻的见解，但也促使人们进一步探索相关的特定大脑区域、所采用的统计方法以及对不同精神分裂症亚型的影响。本文旨在通过提出未来研究和方法改进的领域来补充讨论。

引用次数: 0

Combining static and dynamic brain network analysis with machine learning for enhanced diagnosis of major depressive disorder 将静态和动态脑网络分析与机器学习相结合，以增强重度抑郁症的诊断

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Psychiatry Research: Neuroimaging

Pub Date : 2025-10-14 DOI: 10.1016/j.pscychresns.2025.112076

Chenjing Sun , Ruping Feng , Mengyuan Liu , Siyuan Ma , Jiaxin Tai , Jing Hu , Jin Li , Ning Qiang

Major Depressive Disorder (MDD) is a common mental disorder that severely impacts patients' quality of life and social functioning. Early diagnosis is crucial for improving treatment outcomes, so rapid and accurate diagnosis of MDD is of significant importance. This paper combines static and dynamic functional connectivity analyses based on fMRI data and proposes a novel feature selection method to identify and classify brain network abnormalities in MDD patients. The advantage of this method lies in enhancing classification accuracy through feature fusion while simultaneously reducing feature dimensionality. First, whole-brain correlation analysis is performed based on fMRI functional connectivity, followed by Rich Club analysis and sliding window methods to investigate the topological properties of the intrinsic functional brain network in MDD patients. Finally, the abnormal brain network is used as a feature to classify and diagnose MDD patients and healthy controls, achieving a classification accuracy of 90.28 %. This result validates that the identified abnormal brain networks in this study have clinical significance for assisting in the diagnosis of MDD.

重度抑郁症（MDD）是一种常见的精神障碍，严重影响患者的生活质量和社会功能。早期诊断对改善治疗效果至关重要，因此快速准确诊断重度抑郁症具有重要意义。本文将基于fMRI数据的静态和动态功能连接分析相结合，提出了一种新的特征选择方法来识别和分类MDD患者的脑网络异常。该方法的优点在于通过特征融合提高了分类精度，同时降低了特征维数。首先，基于fMRI功能连通性进行全脑相关分析，然后采用Rich Club分析和滑动窗口方法研究重度抑郁症患者内在功能脑网络的拓扑特性。最后，将异常脑网络作为特征对MDD患者和健康对照进行分类诊断，分类准确率达到90.28%。这一结果验证了本研究发现的异常脑网络对于协助MDD的诊断具有临床意义。

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引用次数: 0

Repetitive transcranial magnetic stimulation for nicotine addiction: A regional homogeneity study based on resting-state fMRI 重复经颅磁刺激治疗尼古丁成瘾：基于静息状态功能磁共振成像的区域均匀性研究

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Psychiatry Research: Neuroimaging

Pub Date : 2025-10-10 DOI: 10.1016/j.pscychresns.2025.112077

Zhiqiang Li , Xuan Sha , Qiaoli Zhang , Siyin Li , Mei Xie , Tao Wang , Dongyan Chen , Enhui Xin , Jianjun Zhang

Background

Previous studies have demonstrated the efficacy of transcranial magnetic stimulation (TMS) on treating nicotine addiction. However, the underlying mechanisms remain unclear. This study aims to investigate the effects of repetitive TMS (rTMS) on nicotine addiction using resting-state functional magnetic resonance imaging (rs-fMRI).

Materials and methods

In this study, adult male participants with nicotine addiction were prospectively recruited, and assigned to either the rTMS group (n = 19) or Sham group (n = 12). Two groups underwent ten sessions of either real or sham rTMS treatment over a two-week period. Clinical assessments related to smoking craving and rs-fMRI scans were conducted before and after treatment. The regional homogeneity (ReHo) was utilized to explore differences in local neural synchronization between the rTMS and Sham groups.

Results

After treatment, the smoking cravings were significantly reduced in two groups. Significant group-by-time interaction effects were observed in the left orbital part of the inferior frontal gyrus, left middle frontal gyrus (MFG), and right angular gyrus (AG). Post-hoc analyses revealed that, compared with pre-treatment, the rTMS group exhibited increased ReHo values after treatment in these areas, while the Sham group exhibited decreased values. Furthermore, within the rTMS group, post-treatment ReHo values in the left MFG were negatively correlated with post-treatment short Tobacco Craving Questionnaire (sTCQ)-Impulse scores. Similarly, the changes in ReHo values of the left MFG from pre- to post-treatment within the rTMS group were negatively correlated with changes in sTCQ-Impulse scores.

Conclusion

Our findings demonstrated that rTMS treatment may improve nicotine-related dependence by modulating local neural synchronization in the prefrontal cortex (PFC) and AG. Furthermore, ReHo values in the left MFG may serve as a promising neuroimaging biomarker for predicting nicotine addiction cessation.

背景先前的研究已经证实经颅磁刺激（TMS）治疗尼古丁成瘾的有效性。然而，潜在的机制仍不清楚。本研究旨在利用静息状态功能磁共振成像（rs-fMRI）研究重复性经颅磁刺激（rTMS）对尼古丁成瘾的影响。材料与方法本研究前瞻性地招募了尼古丁成瘾的成年男性参与者，并将其分为rTMS组（n = 19）和Sham组（n = 12）。两组在两周的时间里接受了10次真实或虚假的经颅磁刺激治疗。在治疗前后进行了与吸烟渴望相关的临床评估和磁共振成像扫描。利用区域同质性（ReHo）来探讨rTMS组和Sham组局部神经同步的差异。结果治疗后，两组患者吸烟欲望均明显降低。在左额下回眶部、左额中回和右角回均观察到显著的组-时间相互作用效应。事后分析显示，与治疗前相比，rTMS组治疗后这些区域的ReHo值增加，而Sham组治疗后这些区域的ReHo值减少。此外，在rTMS组中，治疗后左侧MFG的ReHo值与治疗后短烟草渴望问卷(sTCQ)-冲动得分呈负相关。同样，rTMS组左MFG从治疗前到治疗后ReHo值的变化与sTCQ-Impulse评分的变化呈负相关。结论rTMS治疗可能通过调节前额叶皮质（PFC）和AG的局部神经同步来改善尼古丁相关依赖。此外，左侧MFG中的ReHo值可能作为预测尼古丁成瘾停止的有希望的神经成像生物标志物。

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引用次数: 0

Protocol for a randomised controlled pilot trial for transcranial direct current stimulation enhanced exposure and response prevention with feedback informed post-intervention maintenance of gains for obsessive compulsive disorder 经颅直流电刺激增强暴露和反应预防的随机对照试验方案，反馈告知干预后维持强迫症的收益

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Psychiatry Research: Neuroimaging

Pub Date : 2025-10-01 DOI: 10.1016/j.pscychresns.2025.112074

Christel Botha , Andrea Loftus , Peta Green , Rebecca Anderson

Background

Case studies examining the benefits of transcranial direct current stimulation (tDCS) enhanced exposure response prevention (ERP) reveal clinically significant improvements in symptoms of obsessive-compulsive disorder (OCD). In the absence of control conditions, the validity of these findings requires further study. Efforts are also needed to enhance the longevity of any gains.

Methods

This paper presents the protocol for a pilot randomised controlled trial (RCT) that will, (1) examine the efficacy and longevity of a dual protocol approach combining tDCS and ERP for the treatment of OCD, and (2) pilot a personalised feedback-informed booster treatment protocol for the long-term maintenance of OCD gains. A double-blind between-subjects design is proposed to evaluate pre to post intervention gains in both conditions across an initial 10 session (4 weeks) treatment protocol and 6-month post intervention maintenance phase. tDCS will involve 20 minutes of 2 mA stimulation targeting the orbitofrontal cortex (cathode) and Pre-supplementary Motor Area (anode) as per the frontostriatal model of OCD. The primary outcome of this study is changes in OCD symptom severity (Yale-Brown Obsessive Compulsive Scale; YBOCS). Secondary outcomes include changes in depression, anxiety, quality of life, neurocognitive function (inhibitory control and cognitive flexibility), and treatment acceptability.

Conclusion

The findings of this study will inform treatment approaches by demonstrating the efficacy of tDCS enhanced ERP for the treatment of OCD, and whether any treatment gains can be maintained with feedback-informed booster treatment sessions.

背景：研究经颅直流电刺激（tDCS）增强暴露反应预防（ERP）益处的病例研究显示，强迫症（OCD）症状的临床显著改善。在没有控制条件的情况下，这些发现的有效性需要进一步研究。还需要努力延长任何成果的持续时间。方法：本文提出了一项试点随机对照试验（RCT）的方案，该方案将：(1)检查结合tDCS和ERP治疗强迫症的双重方案方法的疗效和寿命，(2)试点个性化反馈知情的强化治疗方案，以长期维持强迫症的收益。在最初的10个疗程（4周）的治疗方案和干预后6个月的维持阶段，提出了一种双盲受试者设计来评估两种情况下干预前和干预后的收益。根据强迫症的额纹状体模型，tDCS将包括针对眶额额皮质（阴极）和前辅助运动区（阳极）进行20分钟的2毫安刺激。本研究的主要结果是强迫症症状严重程度的变化（耶鲁-布朗强迫症量表；YBOCS）。次要结局包括抑郁、焦虑、生活质量、神经认知功能（抑制控制和认知灵活性）和治疗可接受性的改变。结论本研究的结果将通过证明tDCS增强ERP治疗强迫症的有效性，以及是否可以通过反馈信息加强治疗来维持治疗效果，从而为治疗方法提供信息。

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引用次数: 0

Neural markers in excoriation disorder: Systematic review of neuroimaging evidence 撕破障碍的神经标记物：神经影像学证据的系统回顾

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Psychiatry Research: Neuroimaging

Pub Date : 2025-10-01 DOI: 10.1016/j.pscychresns.2025.112075

Elizabeth A. Hodgdon , Carlie A. Sivils , Jane Ellen Smith , David C. Witherington , Kristina T.R. Ciesielski

Excoriation disorder (ExD), or skin picking disorder, is a chronic body-focused repetitive behavior (BFRB) that leads to severe tissue damage, disfigurement, and psychological distress. Despite its prevalence, the neurobiological etiology of ExD remains poorly understood, hindering early diagnosis and intervention. This systematic review synthesizes findings from neuroimaging studies reporting on neural correlates of ExD. A comprehensive search of PubMed, PsycINFO, and Web of Science identified 18 studies meeting inclusion criteria. Across 784 ExD participants and 530 controls, consistent patterns emerged in brain regions related to sensorimotor inhibition, habit formation, and perceptual-affective interaction. Structural MRI showed smaller volumes in the orbitofrontal cortex, insula, and cerebellum, but increased size of nucleus accumbens, associated in previous studies with deficient inhibitory control. Task-related fMRI showed increased activation in frontal and parietal regions but diminished engagement of posterior cerebellar-prefrontal circuits during sensorimotor coordination, and amplified insula and amygdala responses to aversive stimuli. Resting-state fMRI linked ExD symptom severity with reduced supplementary motor and prefrontal connectivity. The findings consistently point to deviation in networks subserving sensorimotor-emotional integration, one of the earliest stages of brain-behavior development. A hypothesis of ExD as a developmental disorder is suggested, guiding future research to early markers of detection and prevention.

揭皮障碍（ExD），又称抠皮障碍，是一种慢性的以身体为中心的重复性行为（BFRB），会导致严重的组织损伤、毁容和心理困扰。尽管ExD很流行，但其神经生物学病因仍然知之甚少，阻碍了早期诊断和干预。本系统综述综合了ExD神经相关的神经影像学研究结果。对PubMed、PsycINFO和Web of Science进行全面搜索，确定了18项符合纳入标准的研究。在784名ExD参与者和530名对照组中，与感觉运动抑制、习惯形成和感知情感互动相关的大脑区域出现了一致的模式。结构MRI显示眶额皮质、脑岛和小脑体积较小，但伏隔核体积增大，在先前的研究中与抑制控制不足有关。任务相关的功能磁共振成像显示，在感觉运动协调过程中，额叶和顶叶区域的激活增加，但小脑后部-前额叶回路的参与减少，并且对厌恶刺激的岛和杏仁核反应增强。静息状态fMRI将ExD症状严重程度与辅助运动和前额叶连通性降低联系起来。研究结果一致指出，服务于感觉-运动-情绪整合的网络存在偏差，而感觉-运动-情绪整合是大脑行为发展的最早阶段之一。提出了ExD是一种发育障碍的假设，指导未来研究早期发现和预防的标志物。

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引用次数: 0

Incarcerated adolescents scoring high on the Brown Attention-Deficit Disorder Scale are characterized by impairments within brain regions associated with executive control: A source-based morphometry study 被监禁的青少年在布朗注意力缺陷障碍量表上得分高，其特征是与执行控制相关的大脑区域受损：一项基于源的形态测量学研究。

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Psychiatry Research: Neuroimaging

Pub Date : 2025-09-17 DOI: 10.1016/j.pscychresns.2025.112065

J. Michael Maurer , Corey H. Allen , Samantha N. Rodriguez , Keith A. Harenski , David D. Stephenson , Bethany G. Edwards , Nathaniel E. Anderson , Carla L. Harenski , Vince D. Calhoun , Kent A. Kiehl

Initially designed to assess executive control deficits for individuals meeting criteria for attention-deficit/hyperactivity disorder (ADHD), the Brown Attention-Deficit Disorder Scale (BADDS) is now frequently used to assess such deficits more broadly. However, no existing studies have investigated whether individuals scoring high on the BADDS are characterized by impairments within higher-order brain regions associated with executive control. Here, we investigated this association among incarcerated adolescents (205 boys and 35 girls). We incorporated the use of source-based morphometry (SBM), a data-driven, multivariate approach to identify large-scale structural brain networks. In separate analyses performed with incarcerated boys and girls, we observed that higher BADDS total scores were related to reduced loading coefficients in SBM components comprised of brain regions associated with executive control (e.g., superior/middle frontal gyrus, superior/inferior parietal lobule, and middle temporal gyrus). These structural impairments suggest participants scoring high on the BADDS are characterized by executive control deficits, including domains such as self-regulation, working memory, and sustained attention. Our results add to a growing body of literature suggesting that the BADDS serves as a reliable measure of executive control deficits. Further, our results support the use of the BADDS in samples beyond individuals strictly meeting criteria for ADHD.

布朗注意缺陷障碍量表（badd）最初设计用于评估符合注意缺陷/多动障碍（ADHD）标准的个人的执行控制缺陷，现在经常用于更广泛地评估这种缺陷。然而，目前还没有研究调查badd得分高的个体是否以与执行控制相关的高阶大脑区域受损为特征。在这里，我们调查了被监禁的青少年（205名男孩和35名女孩）的这种关联。我们采用了基于源的形态测定法（SBM），这是一种数据驱动的多变量方法，用于识别大规模的脑结构网络。在对被监禁的男孩和女孩进行的单独分析中，我们观察到较高的badd总分与由与执行控制相关的大脑区域（例如，额上回/中回、顶叶上/下小叶和颞中回）组成的SBM组件的负荷系数降低有关。这些结构性损伤表明，badd得分高的参与者的特点是执行控制缺陷，包括自我调节、工作记忆和持续注意力等领域。我们的结果增加了越来越多的文献，表明badd可以作为执行控制缺陷的可靠测量。此外，我们的结果支持在严格符合ADHD标准的个体之外的样本中使用badd。

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引用次数: 0