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Quantitative brain regional relaxometry metrics for early diagnosis of Parkinson's disease 定量脑区域松弛测量法在帕金森病早期诊断中的应用
IF 2.1 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2025-12-30 DOI: 10.1016/j.pscychresns.2025.112120
Miao Chen , PuYeh Wu , Wenjia Wang , YiFei Zhang , Rui Zhang , Jinpeng Qi , Zhibo Liang , Lihong Gao , Gang Zhang

Background

The early identification of Parkinson's disease (PD) prior to the emergence of motor symptoms is paramount for effective treatment and mitigation of disease progression. Moreover, early predictions and assessments of disease progression in certain patients are critical for timely clinical interventions.

Purpose

This study investigates the neuroanatomical alterations in various brain regions during the initial stages and progression of PD, to explore the potential of quantitative regional metrics as candidate imaging markers for early diagnosis and disease progression.

Materials and Methods

We enrolled 31 PD patients and 25 healthy controls (HCs), categorizing PD patients into early-stage Parkinson's (ESP) (n = 22) and advanced-stage Parkinson's (ASP)(n = 9) based on the Hoehn and Yahr grading. The study employed 3D T1BRAVO and synthetic MRI for data acquisition, followed by voxel-based morphometry (VBM) and extraction of T1, T2, and proton density (PrD) values. Comparative analysis of brain volume and regional relaxation metrics was performed among the groups. A classification model based on regions showing significant group differences was evaluated using internal cross-validation.

Results

Significant variations were identified in specific brain regions when comparing the ESP group with HCs, particularly in the right Calcarine_T1GM and left Cuneus_T1GM regions. Additionally, notable differences were discerned between the ESP group and the ASP group, specifically in the left Putamen_T1GM, left ParaHippocampal_T1WM, Precentral_T2WM, left ParaHippocampal_T2WM, Anterior Cingulate Cortex (ACC)_T2WM, and left Putamen_PDGM regions. Scatter plot analysis revealed a strong correlation between these brain regions (with the exception of left ParaHippocampal_T2WM and left Putamen_PDGM) and both the Hoehn and Yahr (H&Y) and Movement Disorder Society (MDS) scores. Under internal cross-validation, T1-based gray-matter regional metrics demonstrated the most stable discriminative performance among the evaluated modalities. Cross-validated classification performance was moderate, particularly for distinguishing ESP from ASP, indicating limited but potentially informative progression-related signals.

Conclusion

Synthetic MRI–derived regional relaxometry reveals stage-related brain alterations in PD. T1-based gray-matter metrics show relatively robust performance under internal validation and may serve as candidate imaging markers associated with early disease-related changes and progression in Parkinson’s disease. However, all classification results should be regarded as exploratory and warrant further validation in larger, independent cohorts.
在运动症状出现之前早期识别帕金森病(PD)对于有效治疗和减缓疾病进展至关重要。此外,对某些患者疾病进展的早期预测和评估对于及时的临床干预至关重要。目的研究帕金森病早期和进展过程中各脑区神经解剖学改变,探讨定量区域指标作为早期诊断和疾病进展的候选影像学指标的潜力。材料与方法我们招募了31例PD患者和25例健康对照(hc),根据Hoehn和Yahr分级将PD患者分为早期帕金森(ESP) (n = 22)和晚期帕金森(ASP)(n = 9)。研究采用3D T1BRAVO和合成MRI进行数据采集,然后进行基于体素的形态测量(VBM)和提取T1、T2和质子密度(PrD)值。对比分析各组脑容量和区域松弛指标。采用内部交叉验证方法评估基于区域的显著组差异分类模型。结果ESP组与hc组在特定脑区存在显著差异,特别是在右侧Calcarine_T1GM和左侧Cuneus_T1GM区域。此外,ESP组与ASP组在左侧海马旁t1gm区、左侧海马旁t1wm区、Precentral_T2WM区、左侧海马旁t2wm区、前扣带皮层(ACC)_T2WM区和左侧海马旁pdgm区存在显著差异。散点图分析显示,这些脑区(左侧海马旁区_t2wm和左侧壳门区_pdgm除外)与Hoehn和Yahr (H&;Y)和运动障碍学会(MDS)评分之间存在很强的相关性。在内部交叉验证下,基于t1的灰质区域指标在评估模式中表现出最稳定的判别性能。交叉验证的分类性能一般,特别是区分ESP和ASP,表明有限但潜在的信息进展相关信号。结论合成mri衍生的区域弛豫测量显示PD患者的分期相关脑改变。基于t1的灰质指标在内部验证下显示出相对稳健的表现,可能作为与帕金森病早期疾病相关变化和进展相关的候选成像标志物。然而,所有的分类结果都应该被认为是探索性的,需要在更大的、独立的队列中进一步验证。
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引用次数: 0
Distinct neural correlates between suicide attempters with major depressive disorder and other psychiatric disorders: a multimodal imaging study 自杀未遂者与重度抑郁症和其他精神疾病之间明显的神经关联:一项多模态成像研究
IF 2.1 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2025-12-29 DOI: 10.1016/j.pscychresns.2025.112117
Woo-Sung Kim , Soyolsaikhan Odkhuu , Ariana Setiani , Ling Li , Ji-Young So , Shahida Nazir , Young-Chul Chung

Background

Suicide attempters (SA) with mild diagnoses other than major depressive disorder (MDD) are underexplored. This study aimed to investigate neuroimaging abnormalities in SA with MDD (SA-MDD), SA with other psychiatric disorders (OPD) (SA-OPD), and healthy controls (HC) using MRI data. Associations between altered findings in the patient groups and anger, negative schema, or rumination were further examined.

Methods

We recruited SA who visited the emergency department and divided them into two groups: SA-MDD (n = 52) and SA-OPD (n = 24). Age-, sex-, and education-matched HC) (n = 100) participated in the study. Cortical thickness, surface area, and subcortical volume were measured using structural magnetic resonance imaging (MRI). Regional analysis and seed-based functional connectivity (FC) analyses were performed using resting-state functional MRI. Partial Pearson or Spearman correlation with psychological variables was conducted.

Results

Widespread decreases in cortical thickness and larger cortical surface areas in some regions were observed in both SA-MDD and SA-OPD. However, decreased hippocampal volume was observed only in SA-MDD. Altered FC was more prominent in SA-MDD than in SA-OPD. In addition, significant associations between altered seed-based FC and negative schema were observed in both groups. Importantly, the associations with anger and rumination were evident only in SA-OPD.

Conclusions

These findings suggest that SA-OPD have similar alterations in brain morphometry to SA-MDD but show less prominent FC alterations. The clinical implications of anger and rumination in SA-OPD warrant further investigation.
背景:除重度抑郁障碍(MDD)外,轻度诊断的自杀未遂者(SA)尚未得到充分的研究。本研究旨在利用MRI数据探讨SA合并MDD (SA-MDD)、SA合并其他精神障碍(OPD) (SA-OPD)和健康对照组(HC)的神经影像学异常。研究人员进一步研究了患者群体中发现的变化与愤怒、消极图式或沉思之间的关系。方法选取急诊就诊的SA患者,将其分为SA- mdd组(n = 52)和SA- opd组(n = 24)。年龄、性别和教育程度相匹配的HC (n = 100)参加了这项研究。使用结构磁共振成像(MRI)测量皮质厚度、表面积和皮质下体积。使用静息状态功能MRI进行区域分析和基于种子的功能连接(FC)分析。与心理变量进行部分Pearson或Spearman相关。结果SA-MDD和SA-OPD均可见大面积皮质厚度减少,部分区域皮质表面积增大。然而,仅在SA-MDD中观察到海马体积减少。与SA-OPD相比,SA-MDD中FC的改变更为明显。此外,在两组中都观察到基于种子的FC改变与消极图式之间的显著关联。重要的是,只有在SA-OPD中,与愤怒和反刍的关联才很明显。结论SA-OPD与SA-MDD有相似的脑形态改变,但FC改变不明显。SA-OPD中愤怒和反刍的临床意义值得进一步研究。
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引用次数: 0
Distinct subcortical connectivity patterns of opioid and stimulant use disorders: A resting-state fMRI study 阿片类药物和兴奋剂使用障碍的不同皮质下连接模式:静息状态fMRI研究
IF 2.1 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2025-12-24 DOI: 10.1016/j.pscychresns.2025.112116
Neli Atanasova , Anna Todeva-Radneva , Kristina Stoyanova , Elena Psederska , Elizabet Dzhambazova , Drozdstoy Stoyanov , Nikoleta Traykova , Jasmin Vassileva
This study investigated resting-state functional connectivity (rsFC) patterns in individuals with opioid use disorder (OUD), stimulant use disorder (StUD) and healthy controls (HC). Using seed-based analysis of key subcortical regions, we found distinct connectivity profiles associated with each substance type. OUD showed reduced connectivity between limbic/basal ganglia structures and sensorimotor regions, along with increased pallidum-angular gyrus connectivity compared to HC. StUD exhibited decreased striatal-default mode network and limbic-prefrontal connectivity relative to HC. Direct comparison between OUD and StUD revealed widespread corticostriatal, striato-cerebellar, and prefrontal-limbic hyperconnectivity in OUD compared to StUD. These substance-specific alterations in intrinsic brain organization may reflect differential neuroadaptations underlying the cognitive and behavioral manifestations of opioid versus stimulant use disorders. Our findings highlight the potential of rsFC patterns as a biomarker for distinguishing among different subtypes of addiction and informing targeted interventions.
本研究探讨了阿片类药物使用障碍(OUD)、兴奋剂使用障碍(StUD)和健康对照(HC)患者的静息状态功能连接(rsFC)模式。使用基于种子的关键皮层下区域分析,我们发现了与每种物质类型相关的独特连接概况。与HC相比,OUD显示边缘/基底神经节结构和感觉运动区域之间的连通性降低,同时苍白球-角回连通性增加。与HC相比,StUD表现出纹状体-默认模式网络和边缘-前额叶连通性下降。对OUD和StUD的直接比较显示,与StUD相比,OUD中皮质纹状体、纹状体-小脑和前额叶-边缘的超连通性广泛存在。这些内在大脑组织的物质特异性改变可能反映了阿片类药物与兴奋剂使用障碍的认知和行为表现背后的不同神经适应。我们的研究结果强调了rsFC模式作为区分不同成瘾亚型和提供有针对性干预措施的生物标志物的潜力。
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引用次数: 0
Deep learning based treatment remission prediction to transcranial direct current stimulation in bipolar depression using EEG power spectral density 基于深度学习的双相抑郁症经颅直流电刺激治疗缓解预测脑电功率谱密度
IF 2.1 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2025-12-22 DOI: 10.1016/j.pscychresns.2025.112115
Jijomon Chettuthara Moncy , Wenyi Xiao , Rachel D. Woodham , Ali-Reza Ghazi-Noori , Hakimeh Rezaei , Elvira Bramon , Philipp Ritter , Michael Bauer , Allan H. Young , Yong Fan , Cynthia H.Y. Fu
Bipolar disorder is characterized by marked changes in mood and activity levels and is a leading cause of disability worldwide. We sought to investigate the application of deep learning methods to electroencephalogram (EEG) signals to predict clinical remission after 6 weeks of home-based transcranial direct current stimulation (tDCS) treatment. Pre-treatment resting-state EEG acquired from 21 bipolar participants was used for this work. A hybrid 1DCNN and GRU model, with input from power spectral density values of theta, beta and gamma frequency bands of the AF7 and TP10 electrodes, achieved a treatment remission prediction accuracy of 78.5% (sensitivity 81.4%, specificity 74.64%).
双相情感障碍的特点是情绪和活动水平的显著变化,是世界范围内致残的主要原因。我们试图研究深度学习方法在脑电图(EEG)信号中的应用,以预测6周家庭经颅直流电刺激(tDCS)治疗后的临床缓解。从21名双相情感障碍参与者获得的治疗前静息状态脑电图用于这项工作。以AF7和TP10电极的theta、beta和gamma频段的功率谱密度值为输入,1DCNN和GRU混合模型的治疗缓解预测准确率为78.5%(灵敏度81.4%,特异性74.64%)。
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引用次数: 0
EEG/MEG-based biomarkers of cognitive training effects in schizophrenia: A systematic review 基于脑电图/脑电图的认知训练效果生物标志物:一项系统综述。
IF 2.1 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2025-12-19 DOI: 10.1016/j.pscychresns.2025.112112
Alp Eren Yüce , Işın Yaman , Serdar Gündoğdu
This systematic review aims to evaluate the effects of cognitive training methods on brain electrical activity in patients with schizophrenia, focusing on studies published between January 2010 and October 2025 in the PubMed and Web of Science databases. Twenty experimental and quasi-experimental studies were included in the study, examining various cognitive training methods, including auditory, visual, emotional, and social skills training. These studies measured Electroencephalography (EEG) and Magnetoencephalography (MEG) metrics, including oscillations, mismatch negativity (MMN), and event-related potentials (ERPs), to assess changes in neural activity associated with schizophrenia. Findings demonstrate that different cognitive training methods may improve neural oscillations, particularly in the gamma and alpha bands, and may enhance cognitive functions such as working memory, attention, and emotional regulation. While some studies have shown limited effects on specific EEG and MEG indices, the overall evidence suggests that personalized cognitive interventions can promote neuroplasticity and cognitive recovery in individuals with schizophrenia. These findings show the potential of integrating EEG/MEG-based biomarkers into clinical practices to enhance the effect of treatment and improve neural outcomes for schizophrenia patients.
本系统综述旨在评估认知训练方法对精神分裂症患者脑电活动的影响,重点关注2010年1月至2025年10月在PubMed和Web of Science数据库中发表的研究。本研究纳入了20项实验和准实验研究,考察了各种认知训练方法,包括听觉、视觉、情感和社交技能训练。这些研究测量了脑电图(EEG)和脑磁图(MEG)指标,包括振荡、失配负性(MMN)和事件相关电位(ERPs),以评估与精神分裂症相关的神经活动变化。研究结果表明,不同的认知训练方法可以改善神经振荡,特别是在γ和α波段,并可能增强认知功能,如工作记忆,注意力和情绪调节。虽然一些研究显示对特定EEG和MEG指标的影响有限,但总体证据表明,个性化认知干预可以促进精神分裂症患者的神经可塑性和认知恢复。这些发现表明,将基于EEG/ meg的生物标志物整合到临床实践中,可以增强治疗效果,改善精神分裂症患者的神经预后。
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引用次数: 0
Disease and state dependent neural markers in adolescents with BD. Understanding the neural bases of mania, depression and remission in a data fusion approach 青少年双相障碍的疾病和状态依赖的神经标记物。用数据融合方法了解躁狂、抑郁和缓解的神经基础。
IF 2.1 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2025-12-18 DOI: 10.1016/j.pscychresns.2025.112113
Xiaoping Yi , Xueying Wang , Mingzhao Ma , Jinfan Zhang , Feifei Wu , Haimiao Huang , Qian Xiao , Xiaoqun Liu , Alessandro Grecucci

Background

Pediatric bipolar disorder (PBD) is a severe and disabling condition marked by alternating episodes of mania and depression, intermitted with periods of remission. A critical challenge in the field is to elucidate the neural mechanisms underlying these distinct mood states, as manic and depressive presentations reflect profoundly different clinical phenotypes. Despite their relevance, the functional and structural brain alterations associated with manic, depressed, and remitted states in PBD remain poorly understood.

Method

In this study, data on Resting-State Regional Homogeneity (ReHo) and grey matter concentration (GMC) were considered from 58 PBD patients and 21 healthy controls (HC), matched for age, gender, education, and IQ. The analysis was conducted using Parallel ICA, a multivariate data-driven approach that identifies joint patterns of covariation across resting-state functional and gray matter features.

Results

Among the nine RS-GM components identified, distinct disease- and state-dependent networks were detected. GM2, a cortico-limbic network, differentiated PBD from HC, suggesting a neural substrate of bipolar disorder independent of mood state. GM9, including the cingulate and the precuneus, distinguished manic from depressed states, while RS7, including the fusiform and occipital regions, was specific to depression compared to HC. RS1, including regions of the DMN, differentiated manic from remitted states.

Conclusions

These findings provide new fresh understanding on the common and separate functional and structural abnormalities displayed during mania, depression and remission phases in bipolar patients.
背景:儿童双相情感障碍(PBD)是一种严重的致残性疾病,其特征是躁狂症和抑郁症交替发作,伴有缓解期。该领域的一个关键挑战是阐明这些不同情绪状态背后的神经机制,因为躁狂和抑郁的表现反映了截然不同的临床表型。尽管它们具有相关性,但与PBD中躁狂、抑郁和缓解状态相关的功能和结构脑改变仍然知之甚少。方法:本研究采用58例PBD患者和21例健康对照(HC)的静息状态区域均匀性(ReHo)和灰质浓度(GMC)数据,这些数据与年龄、性别、教育程度和智商相匹配。该分析使用Parallel ICA进行,这是一种多变量数据驱动的方法,可识别静息状态功能和灰质特征之间的共同变异模式。结果:在鉴定的9个RS-GM成分中,检测到不同的疾病和状态依赖网络。皮质边缘网络GM2将PBD与HC区分开来,提示双相情感障碍的神经基质独立于情绪状态。GM9,包括扣带回和楔前叶,区分躁狂和抑郁状态,而RS7,包括梭状回和枕部,与HC相比,是抑郁症的特异性区域。RS1,包括DMN的区域,区分躁狂和缓和状态。结论:这些发现为双相情感障碍患者在躁狂、抑郁和缓解期所表现出的常见和单独的功能和结构异常提供了新的认识。
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引用次数: 0
Neural correlates of personal agency in borderline personality disorder - An fMRI investigation using attachment-informed autobiographical memories 边缘型人格障碍中个人代理的神经关联——一项使用依恋自传式记忆的fMRI研究。
IF 2.1 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2025-12-17 DOI: 10.1016/j.pscychresns.2025.112111
Emily L Matthews , Ely M Marceau , Charlotte C van Schie , Brin FS Grenyer
Individuals with borderline personality disorder (BPD) have identity disturbance and difficulty with self/other distinction which may be linked to difficulties in personal agency. Neuroimaging research has helped inform underlying deficits linked to sociocognitive functioning, however, no research has specifically investigated neural correlates of personal agency in BPD. We used an attachment-informed autobiographical memory recall task to investigate behavioural and neural mechanisms of personal agency in BPD. Individuals with BPD (n = 34) and nonclinical controls (NCC, n = 35) recalled attachment and neutral memories during functional magnetic resonance imaging (fMRI). Behavioural analyses of affect, agency, and vividness of memories, and event-related fMRI analysis compared neutral and attachment-informed memories. Parametric modulation identified changes in neural activation associated with increasing agency. People with BPD felt less agentic and more negative during recall of attachment-informed memories, compared to NCCs. Agency was similar between groups for neutral memories. We found hyperactivation in the temporal parietal junction (TPJ) and superior temporal gyrus particularly during memories involving more distant attachment figures. Differential activation between BPD and NCC groups based on level of agency was found, including in the right-TPJ. Personal agency is influenced by relational contextual factors, with individuals with BPD being affected in agency when recalling memories with attachment figures. The neural hyperactivation findings provide evidence for how attachment distress or negative relational experiences may be associated with poor personal agency. This has implications for interpersonal functioning in BPD and highlights the importance and challenges of fostering personal agency in treatment.
边缘型人格障碍(BPD)患者存在身份障碍和自我/他人区分困难,这可能与个人代理困难有关。神经影像学研究有助于揭示与社会认知功能相关的潜在缺陷,然而,没有研究专门调查BPD中个人代理的神经相关性。本研究采用依恋自传式记忆回忆任务来研究BPD患者个人代理的行为和神经机制。BPD患者(n = 34)和非临床对照(NCC, n = 35)在功能磁共振成像(fMRI)中回忆起依恋和中性记忆。对情感、代理和生动记忆的行为分析,以及与事件相关的fMRI分析,比较了中性记忆和依恋信息记忆。参数调制确定了与代理增加相关的神经激活的变化。与非人格障碍患者相比,BPD患者在回忆与依恋相关的记忆时感觉更不真实,更消极。对于中性记忆,两组之间的代理是相似的。我们发现在颞顶叶交界处(TPJ)和颞上回过度激活,特别是在涉及较远的依恋人物的记忆中。发现BPD组和NCC组之间基于代理水平的差异激活,包括右侧tpj。个人代理受关系情境因素的影响,BPD患者在回忆与依恋人物有关的记忆时代理受到影响。神经过度激活的发现为依恋痛苦或消极的关系经历如何与糟糕的个人能动性联系在一起提供了证据。这对BPD的人际功能有影响,并突出了在治疗中培养个人能动性的重要性和挑战。
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引用次数: 0
Meta-analysis of aberrant white matter microstructure and gray matter volume in autism spectrum disorder 自闭症谱系障碍患者白质微观结构和灰质体积异常的meta分析
IF 2.1 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2025-12-17 DOI: 10.1016/j.pscychresns.2025.112110
Yu Jiang , Qiuying Tao , Ying Wei , Shengli Shi

Objective

Our aim was to conduct a comprehensive meta-analysis of structural neuroimaging studies investigating white matter (WM) microarchitecture and gray matter volume (GMV) abnormalities in patients with autism spectrum disorder (ASD).

Methods

Totally 24 diffusion tensor imaging studies using tract-based spatial statistics (TBSS) or voxel-based analysis (VBA) approach were included in this meta-analysis. The discrepancies in WM fractional anisotropy, mean diffusivity, axial diffusivity and radial diffusivity between ASD patients and typically developing (TD) individuals and the results of two common methods were compared. Besides, we detect GMV alternations by analyzing 44 voxel-based morphometry studies in ASD and comparing the difference in different developing stages.

Results

Compared with TD, ASD exhibited significantly WM microstructure alterations in corpus callosum, cortico-spinal projections, anterior thalamic projections, superior longitudinal fasciculus and middle cerebellar peduncles. There is some heterogeneity in aberrant WM microstructure between the TBSS and VBA subgroup. ASD had increased GMV in gyrus rectus, superior and inferior temporal gyrus, and precentral gyrus, and decreased GMV in cerebellum, anterior cingulate/paracingulate gyri, cingulum, and inferior parietal gyri. ASD displayed an age-related trajectory of brain morphometry.

Conclusion

Our main findings reveal the variable WM microarchitecture and GMV in ASD and offer a neuroanatomical framework that may guide multimodal and longitudinal research.
我们的目的是对自闭症谱系障碍(ASD)患者白质(WM)微结构和灰质体积(GMV)异常的结构神经影像学研究进行全面的荟萃分析。方法采用基于束的空间统计(TBSS)或基于体素的分析(VBA)方法,共纳入24项弥散张量成像研究。比较ASD患者与典型发展(TD)个体WM分数各向异性、平均扩散率、轴向扩散率和径向扩散率的差异以及两种常用方法的结果。此外,我们通过分析44个基于体素的ASD形态学研究来检测GMV的变化,并比较不同发育阶段的差异。结果与TD相比,ASD在胼胝体、皮质-脊髓突起、丘脑前突起、上纵束和小脑中蒂的WM微结构发生了显著改变。TBSS和VBA亚组在异常WM微观结构上存在一定的异质性。ASD增加了直回、颞上回、颞下回和中央前回的GMV,降低了小脑、扣带/副扣带前回、扣带和顶叶下回的GMV。ASD表现出与年龄相关的脑形态测量轨迹。结论本研究的主要发现揭示了ASD中可变的WM微结构和GMV,并为多模态和纵向研究提供了神经解剖学框架。
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引用次数: 0
Adaptive network based fuzzy inference system efficientnet for autism spectrum disorder detection with optimization based pivotal region extraction 基于自适应网络的模糊推理系统有效地实现了基于优化的关键区域提取的自闭症谱系障碍检测。
IF 2.1 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2025-12-11 DOI: 10.1016/j.pscychresns.2025.112109
Satish Muppidi , Kishore Bhamidipati , Grandhi Siva Sankar , Anupkumar M. Bongale , Ramesh Babu P
Autism Spectrum Disorder (ASD) refers to abnormal neural activity that may increase the risk of premature brain development issues. Many traditional treatment methods are available for ASD, but they require continuous assessment and analysis of patient behavior. However, traditional models are time-consuming and often lead to unclear outcomes, significantly impacting patient’s social lives and communication ability. Hence, a novel hybrid approach is developed, namely, Adaptive Network Based Fuzzy Inference System EfficientNet (ANFIS-EffNet), which combines the ability of Adaptive Network Based Fuzzy Inference (ANFIS) and EfficientNet by modifying their layers. At first, the input autism brain image is given to the pre-processing stage, performed using Anisotropic diffusion and Region of Interest (ROI) extraction. Next, functional connectivity-based pivotal region extraction is done by Adam War Strategy Optimization (AWSO), a combination of the Adam optimization algorithm and War Strategy Optimization (WSO) technique. Next, feature extraction is carried out by including Learned Invariant Feature Transform (LIFT) and statistical methods. At last, ANFIS-EffNet is employed to detect autism spectrum disorder. The ANFIS-EffNet model has achieved outstanding performance with an accuracy of 93.219 %, sensitivity of 93.670 % and specificity of 93.840 % respectively.
自闭症谱系障碍(ASD)是指异常的神经活动,可能会增加大脑过早发育问题的风险。许多传统的ASD治疗方法是可用的,但它们需要持续评估和分析患者的行为。然而,传统的模式耗时长,往往导致不明确的结果,严重影响患者的社交生活和沟通能力。因此,提出了一种新的混合方法,即基于自适应网络的模糊推理系统效率网(ANFIS- effnet),该方法通过修改其层,将基于自适应网络的模糊推理系统(ANFIS)和高效网的能力结合起来。首先,对输入的自闭症脑图像进行预处理,利用各向异性扩散和感兴趣区域(ROI)提取进行预处理。其次,结合Adam优化算法和War Strategy Optimization (WSO)技术,采用Adam War Strategy Optimization (AWSO)算法进行基于功能连通性的关键区域提取。然后,结合学习不变特征变换(LIFT)和统计方法进行特征提取。最后,利用anfiss - effnet对自闭症谱系障碍进行检测。anfiss - effnet模型的准确率为93.219%,灵敏度为93.670%,特异性为93.840%。
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引用次数: 0
Intelligent electroencephalogram feature engineering for rapid mental health diagnosis 快速诊断精神健康的智能脑电图特征工程
IF 2.1 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2025-12-08 DOI: 10.1016/j.pscychresns.2025.112103
Ammu Kripalal , C. Sekar
Schizophrenia is one of the serious disorders and, if left untreated, can result in a range of problems with cognition, behavior, and emotions that affect every area of life. Diagnosis based on behavioral and clinical investigations remains difficult with schizophrenia symptoms which are complex and heterogenic. Early detection of schizophrenia is essential for the timely treatment leading to betterment of the life of patients. In this study based on machine learning algorithms, we have identified the relevant set of features from the electroencephalogram (EEG) signal to improve the classification accuracy of patients with schizophrenia and healthy controls. Combinations of these identified relevant features have been used to diagnose schizophrenia.Furthermore, we validated this same feature set as the high performing feature subset on an independent dataset, confirming its robustness and generalizability. The results show that the selected features from the EEG signal achieve the highest accuracy of 94.7% and 96.4% for Logistic Regression (LR) and Support Vector Machines (SVM) respectively with reduced data. Reduction in training data with this feature selection enhances the performance of edge devices that are optimized for applications such as brain computer interfaces, neurological disorder detection, cognitive state monitoring, and neurofeedback training.
精神分裂症是一种严重的疾病,如果不及时治疗,会导致认知、行为和情绪方面的一系列问题,影响生活的方方面面。基于行为和临床调查的精神分裂症症状的诊断仍然是困难的,这是复杂和异质性的。精神分裂症的早期发现对于及时治疗和改善患者的生活至关重要。在这项基于机器学习算法的研究中,我们从脑电图(EEG)信号中识别出相关的特征集,以提高精神分裂症患者和健康对照组的分类准确性。这些已确定的相关特征的组合已用于诊断精神分裂症。此外,我们在独立数据集上验证了相同的特征集作为高性能特征子集,证实了其鲁棒性和泛化性。结果表明,采用逻辑回归(LR)和支持向量机(SVM)对脑电信号特征进行约简处理,准确率分别达到94.7%和96.4%。通过这种特征选择减少训练数据,增强了边缘设备的性能,这些设备针对脑机接口、神经系统疾病检测、认知状态监测和神经反馈训练等应用进行了优化。
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Psychiatry Research: Neuroimaging
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