Psychiatry Research: Neuroimaging最新文献_第2页

Multimodal imaging of the amygdala in non-clinical subjects with high vs. low autistic-like social skills traits 杏仁核多模态成像在自闭症类社交技能特征较高与较低的非临床受试者中的应用。

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Psychiatry Research: Neuroimaging

Pub Date : 2025-01-01 DOI: 10.1016/j.pscychresns.2024.111910

Niccolò Zovetti , Tina Meller , Ulrika Evermann , Julia-Katharina Pfarr , Jonas Hoffmann , Andrea Federspiel , Sebastian Walther , Sarah Grezellschak , Andreas Jansen , Ahmad Abu-Akel , Igor Nenadić

Recent clinical and theoretical frameworks suggest that social skills and theory of mind impairments characteristic of autism spectrum disorder (ASD) are distributed in the general population on a continuum between healthy individuals and patients. The present multimodal study aimed at investigating the amygdala's function, perfusion, and volume in 56 non-clinical subjects from the general population with high (n = 28 High-SOC) or low (n = 28 Low-SOC) autistic-like social skills traits. Participants underwent magnetic resonance imaging to evaluate the amygdala's functional connectivity at rest, blood perfusion by means of arterial spin labelling, its activation during a face evaluation task and lastly grey matter volumes. The High-SOC group was characterised by higher blood perfusion in both amygdalae, lower volume of the left amygdala and higher activations of the right amygdala during processing of human faces with fearful value. Resting state analyses did not reveal any significant difference between the two groups. Overall, our results highlight the presence of overlapping morpho-functional alterations of the amygdala between healthy individuals and ASD patients confirming the importance of the amygdala in this disorder and in social and emotional processing. Our findings may help disentangle the neurobiological facets of ASD elucidating aetiology and the relationship between clinical symptomatology and neurobiology.

最近的临床和理论框架表明，自闭症谱系障碍（ASD）所特有的社交技能和心智理论障碍在普通人群中的分布介于健康人和患者之间。本项多模态研究旨在调查 56 名具有高度（n = 28 High-SOC）或低度（n = 28 Low-SOC）类似自闭症社交技能特征的非临床受试者的杏仁核功能、灌注和体积。受试者接受了磁共振成像检查，以评估杏仁核在静息状态下的功能连接性、通过动脉自旋标记的血液灌注情况、在面部评估任务中的激活情况以及最后的灰质体积。高 SOC 组的特点是两个杏仁核的血液灌注量较高、左侧杏仁核体积较小、右侧杏仁核在处理具有恐惧价值的人脸时被激活的程度较高。静息状态分析并未发现两组之间存在任何显著差异。总之，我们的研究结果突出表明，健康人和自闭症患者的杏仁核存在重叠的形态功能改变，这证实了杏仁核在这种疾病以及社交和情感处理过程中的重要性。我们的研究结果可能有助于厘清自闭症的神经生物学层面，阐明病因以及临床症状与神经生物学之间的关系。

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引用次数: 0

Neuroanatomical alterations in young boys and adolescents with Klinefelter syndrome 年轻男孩和青少年Klinefelter综合征的神经解剖学改变。

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Psychiatry Research: Neuroimaging

Pub Date : 2025-01-01 DOI: 10.1016/j.pscychresns.2024.111929

Lara C. Foland-Ross , Tracy L. Jordan , Matthew J. Marzelli , Judith L. Ross , Allan L. Reiss

Klinefelter syndrome (KS, 47,XXY) is a common sex chromosome aneuploidy in males that is characterized by pubertal developmental delays and a wide range of alterations in cognitive, social and emotional functioning. The neural bases of these behavioral symptoms, however, are unclear. A total of 130 boys and adolescents, including 67 males with KS (11.5 ± 2.8 years) and 63 typically developing (TD; control) males (10.6 ± 2.8 years) underwent MRI scanning and pubertal assessment. Group differences in regional gray matter volume was examined using voxel-based morphometry while controlling for age at scan and total gray matter volume. Thresholded statistical significance maps indicated widespread reductions in frontal and temporal and cerebellar gray matter in males with KS relative to TD males, as well as increases in parietal and occipital gray matter. Secondary analyses explored potential associations between GMV in these regions and pubertal development. Lower testicular volume was a significant predictor of reduced GMV in frontal, temporal and cerebellar subregions, even after accounting for group status (KS, TD). Taken together, these findings add support for a neuroanatomical phenotype of KS and provide initial evidence for a role of pubertal development in KS-associated differences in gray matter structure. Future studies that examine the influence of testosterone supplementation on GMV in males with KS are warranted.

Klinefelter综合征（KS, 47，XXY）是男性常见的性染色体非整倍体，其特征是青春期发育迟缓和认知、社交和情感功能的广泛改变。然而，这些行为症状的神经基础尚不清楚。共有130名男孩和青少年，包括67名男性KS（11.5±2.8岁）和63名典型发展(TD；对照组)男性（10.6±2.8岁）接受MRI扫描和青春期评估。在控制扫描年龄和总灰质体积的同时，使用基于体素的形态测量法检查区域灰质体积的组间差异。阈值统计显著性图显示，与TD男性相比，KS男性的额叶、颞叶和小脑灰质普遍减少，顶叶和枕叶灰质增加。二级分析探讨了这些区域GMV与青春期发育之间的潜在关联。较小的睾丸体积是额叶、颞叶和小脑亚区GMV减少的重要预测因子，即使在考虑组状态后也是如此（KS， TD）。综上所述，这些发现为KS的神经解剖学表型提供了支持，并为青春期发育在KS相关的灰质结构差异中所起的作用提供了初步证据。未来的研究将检验补充睾酮对KS男性GMV的影响。

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引用次数: 0

Objective outcome prediction in depression through functional MRI brain network dynamics 通过功能性MRI脑网络动态预测抑郁症的客观预后。

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Psychiatry Research: Neuroimaging

Pub Date : 2024-12-30 DOI: 10.1016/j.pscychresns.2024.111945

Jesper Pilmeyer , Stefan Rademakers , Rolf Lamerichs , Vivianne van Kranen-Mastenbroek , Jacobus FA Jansen , Marcel Breeuwer , Svitlana Zinger

Research purpose

Subjective clinical decision-making in major depressive disorder (MDD) may result in low treatment effectiveness. This study aims to identify objective predictors of MDD outcome using resting-state functional MRI scans, acquired from 25 MDD patients at baseline. Over a year, patients were assessed every 3 months, labeled as positive or negative outcome (change in depression severity). Group independent component analysis (GICA) identified (sub)networks at different orders, from which static and dynamic (wavelet) fMRI features were extracted. Binary classifiers performed MDD outcome prediction at each follow-up.

Principal Results

The total coherence feature, reflecting network interactivity, yielded the highest performance (area under the curve (AUC) of 0.70). In the positive outcome group, total coherence between the default mode network and ventral salience network was increased at all follow-ups. Classification using this feature alone further demonstrated its discriminating capability (AUC of 0.76 ± 0.10 over all follow-ups). These results suggest that a higher switching capability between internal and external brain states predicts symptom improvement. Higher GICA orders, where major networks are divided into subnetworks, yielded optimal classification performance.

Major Conclusions

Total coherence, a dynamic fMRI measure, achieved the highest classification performance. These findings contribute to the identification of prognostic biomarkers in MDD.

研究目的：重度抑郁障碍（MDD）患者的主观临床决策可能导致治疗效果较低。本研究旨在通过静息状态功能MRI扫描确定MDD结果的客观预测因素，该扫描来自25名MDD患者的基线。在一年中，每3个月对患者进行一次评估，标记为阳性或阴性结果（抑郁严重程度的变化）。组独立分量分析（GICA）识别了不同阶次的子网络，从中提取了静态和动态（小波）fMRI特征。二元分类器在每次随访中进行MDD结局预测。主要结果：反映网络交互性的总相干性产生了最高的性能（曲线下面积（AUC）为0.70）。在积极结果组中，默认模式网络和腹侧显著性网络之间的总一致性在所有随访中都有所增加。单独使用该特征进行分类进一步证明了其判别能力（所有随访的AUC为0.76±0.10）。这些结果表明，大脑内外状态之间更高的转换能力预示着症状的改善。较高的GICA阶数（将主要网络划分为子网络）产生了最佳的分类性能。主要结论：全相干性，一个动态fMRI测量，达到最高的分类性能。这些发现有助于确定重度抑郁症的预后生物标志物。

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引用次数: 0

Investigating the changes in volumes of the limbic system and hypothalamic-subnuclei in patients with depression 研究抑郁症患者边缘系统和下丘脑亚核体积的变化。

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Psychiatry Research: Neuroimaging

Pub Date : 2024-12-24 DOI: 10.1016/j.pscychresns.2024.111942

Daun Shin , Kyu-Man Han , Sun-Uk Lee , Byung-Jo Kim , Sung-Bom Pyun , Woo Suk Tae , Byung-Joo Ham

Background

Depression is consistently linked to changes in the hypothalamus, HPA axis, and limbic system, though the specific substructures involved remain unclear. This study aims to explore the relationship between depression and the volumes of specific nuclei within these brain regions. Understanding these connections could provide deeper insights into the biological mechanisms underlying depression.

Methods

Seventy-three healthy individuals and 39 patients with depression were assessed using the Beck Depression Inventory or Hamilton Depression Rating Scale. All participants underwent 3.0T MRI, and the volumes of subnuclei in the hypothalamus and limbic system were measured.

Results

The results revealed increased volumes in both the inferior tubular areas of the hypothalamus and the left hypothalamus in the patient group with depression. Moreover, the left infTub volume initially increased during the first three years of depression, followed by a decrease, suggesting distinct structural changes between early and chronic stages of the illness.

Conclusions

Alterations in the left inferior tubular area volume suggest a connection between the hypothalamus and the chronicity of depressive symptoms. Further exploration of specific nuclei in the hypothalamus promises deeper insights into depression's biological mechanisms.

背景：抑郁症一直与下丘脑、下丘脑轴和边缘系统的变化有关，尽管具体涉及的亚结构尚不清楚。这项研究旨在探索抑郁症与这些大脑区域内特定核的体积之间的关系。了解这些联系可以更深入地了解抑郁症的生物学机制。方法：采用贝克抑郁量表或汉密尔顿抑郁评定量表对73名健康个体和39例抑郁症患者进行抑郁评定。所有参与者都接受了3.0T MRI，测量了下丘脑和边缘系统的亚核体积。结果：抑郁症患者下丘脑下管区和左下丘脑体积均增加。此外，在抑郁症的前三年，左脑容量最初增加，随后减少，这表明在疾病的早期和慢性阶段之间存在明显的结构变化。结论：左侧下小管面积体积的改变提示下丘脑与抑郁症状的慢性性之间存在联系。对下丘脑特定核的进一步探索有望对抑郁症的生物学机制有更深入的了解。

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引用次数: 0

Altered coupling relationships across resting-state functional connectivity measures in schizophrenia, bipolar disorder, and attention deficit/hyperactivity disorder 精神分裂症、双相情感障碍和注意缺陷/多动障碍静息状态功能连接测量中耦合关系的改变

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Psychiatry Research: Neuroimaging

Pub Date : 2024-12-18 DOI: 10.1016/j.pscychresns.2024.111943

Lu Ma , Shanshan Jiang , Wei Tang

Resting-state functional connectivity (rsFC) measures have enjoyed significant success in discovering the neuropathological characteristics of schizophrenia (SZ), bipolar disorder (BD), and attention deficit/hyperactivity disorder (ADHD). However, it is unknown whether and how the spatial and temporal coupling relationships across rsFC measures would be altered in these psychiatric disorders. Here, resting-state fMRI data were obtained from a transdiagnostic sample of healthy controls (HC) and individuals with SZ, BD, and ADHD. We used Kendall's W to compute volume-wise and voxel-wise concordance across rsFC measures, followed by group comparisons. In terms of the spatial coupling, both SZ and BD individuals exhibited decreased volume-wise concordance compared with HC. Regarding the temporal coupling, SZ individuals showed decreased voxel-wise concordance in the right lateral occipital cortex relative to HC. BD individuals exhibited decreased voxel-wise concordance in the bilateral basal forebrain and bilateral superior/middle temporal gyrus compared to HC. Additionally, correlation analyses demonstrated positive associations of voxel-wise concordance in the left basal forebrain with negative symptoms including alogia and affective flattening in pooled SZ and BD individuals. Our findings of distinct patterns of spatial and temporal decoupling across rsFC measures among SZ, BD, and ADHD may provide unique insights into the neuropathological mechanisms of these psychiatric disorders.

静息状态功能连接（rsFC）测量在发现精神分裂症（SZ）、双相情感障碍（BD）和注意缺陷/多动障碍（ADHD）的神经病理特征方面取得了重大成功。然而，目前尚不清楚rsFC测量的时空耦合关系是否以及如何在这些精神疾病中被改变。静息状态fMRI数据来自健康对照（HC）和SZ、BD和ADHD患者的转诊断样本。我们使用Kendall's W来计算rsFC测量中体积和体素的一致性，然后进行组比较。在空间耦合方面，SZ和BD个体均表现出比HC个体更低的体积一致性。在时间耦合方面，与HC相比，SZ个体在右侧枕侧皮层的体素一致性降低。与HC相比，双侧基底前脑和双侧颞上回/中回的体素一致性降低。此外，相关分析表明，在合并SZ和BD个体中，左基底前脑体素一致性与包括痛症和情感性扁平化在内的阴性症状呈正相关。我们在SZ、BD和ADHD的rsFC测量中发现了不同的时空解耦模式，这可能为这些精神疾病的神经病理机制提供了独特的见解。

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引用次数: 0

Emotion regulation in self-injurious youth: A tale of two circuits 自我伤害青少年的情绪调节：两个回路的故事。

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Psychiatry Research: Neuroimaging

Pub Date : 2024-12-18 DOI: 10.1016/j.pscychresns.2024.111944

Carmen Santana-Gonzalez , Janani Ranatunga , Giang Nguyen , Brianna Greiskalns , Natasha Das , Evan Lattimer , Matthew Maurice , Gina Yi , Anna-Lena Zietlow , Monika Eckstein , Anna Zilverstand , Karina Quevedo

Two emotion regulation (ER) networks, the amygdala and ventral striatum (VS) circuits underpin defensive and reward processes related to non-suicidal self-injury (NSSI). Youth who engaged in non-suicidal self-injury behavior (NSSIB) and healthy controls either watched images passively (passive condition) or increased their positive affect during positive/neutral images and decreased their negative affect during negative and self-harm images (regulate condition) in the scanner. NSSI youth showed higher amygdala to precuneus and inferior parietal lobe (IPL) connectivity while regulating emotions during self-harm images, a pattern which was associated with higher self-injury frequency. NSSI youth showed higher VS connectivity to the fusiform gyrus and parahippocampus while regulating emotions elicited by self-harm and positive images, which was in turn linked to higher self-harm frequency and relief after NSSI. Higher amygdala-precuneus and IPL connectivity in NSSI youth suggest greater self-identification with, or difficulty regulating negative affect elicited by, self-injury images. High VS-fusiform gyrus and parahippocampus connectivity during positive and self-harm images implies reward anomalies and/or greater effort to regulate positive affect. VS circuit's’ links to relief and NSSIB frequency suggest VS reward-based learning as biomarker of NSSIB endurance. We discovered ER mechanisms in adolescents with NSSIB and promising targets for effective NSSIB treatment.

杏仁核和腹侧纹状体两种情绪调节（ER）网络支持与非自杀性自伤（NSSI）相关的防御和奖励过程。参与非自杀性自伤行为的青少年和健康对照组在扫描仪上被动观看图像（被动条件）或在积极/中性图像（调节条件）时增加积极情绪，在消极和自伤图像（调节条件）时减少消极情绪。自伤青少年在自伤图像中表现出较高的杏仁核-胼胝体前叶和下顶叶（IPL）连通性，这种模式与较高的自伤频率有关。自伤青少年在调节由自伤和积极图像引发的情绪时，与梭状回和副海马体的VS连通性较高，这与自伤后较高的自伤频率和缓解有关。自伤青少年的杏仁核-楔前叶和IPL连接性较高，表明他们对自伤图像的自我认同程度较高，或难以调节自伤图像引发的负面影响。在正面和自我伤害图像中，高伏梭状回和副海马体连通性意味着奖励异常和/或调节正面影响的更大努力。VS回路与缓解和NSSIB频率的联系表明，基于VS奖励的学习是NSSIB耐力的生物标志物。我们发现了青少年NSSIB的内质网机制和有效治疗NSSIB的有希望的靶点。

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引用次数: 0

Neural regulation of pain anticipation is associated with mindful behavior change in patients with anxiety or depression: A pilot study 疼痛预期的神经调节与焦虑或抑郁患者的正念行为改变有关：一项初步研究。

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Psychiatry Research: Neuroimaging

Pub Date : 2024-12-11 DOI: 10.1016/j.pscychresns.2024.111941

Michael Datko , Jacqueline Lutz , Richa Gawande , Alexandra Comeau , Jenny Gan , My Ngoc To , Gaelle Desbordes , Todd Griswold , Jean King , Eric Loucks , Vitaly Napadow , Zev Schuman-Olivier

Behavior change often requires overcoming discomfort or difficult emotions. Emotional dysregulation associated with anxiety or depression may prevent behavior change initiation among people managing chronic illness. Mindfulness training may catalyze chronic disease self-management by reducing experiential avoidance of aversive experiences that act as barriers to change initiation. Using a fMRI evoked pain task, we examined the effects of 8 weeks of Mindfulness Training for Primary Care (MTPC) on brain response to the anticipation of a noxious event (i.e., pain) among patients with anxiety and/or depression. We modeled the association between post-MTPC changes in brain response to pain anticipation and post-MTPC Action Plan Initiation (API), a measure of successful initiation of health behavior change. Greater post-MTPC increase in response to pain anticipation in the dorsal medial prefrontal cortex (dmPFC) was associated with higher levels of API (r=0.77, p<0.001). This increase in dmPFC response correlated with post-MTPC self-reported increase in emotion regulation skills related to goal-directed behaviors (r=-0.52, p=0.002). This suggests that mindfulness training increases the capacity to maintain goal-directed behavior in the face of aversive experiences by strengthening neural mechanisms of emotion- and self-regulation supporting successful health behavior change initiation in patients struggling with anxiety and/or depression.

行为改变往往需要克服不适或困难的情绪。与焦虑或抑郁相关的情绪失调可能会阻碍慢性病患者开始改变行为。正念训练可以通过减少对厌恶体验的体验性回避来促进慢性病患者的自我管理，而这种体验性回避是启动改变的障碍。我们利用 fMRI 疼痛诱发任务，研究了为期 8 周的初级保健正念训练（MTPC）对焦虑症和/或抑郁症患者大脑对有害事件（即疼痛）的预期反应的影响。我们模拟了MTPC后大脑对疼痛预期反应的变化与MTPC后行动计划启动（API）之间的关联，后者是衡量成功启动健康行为改变的指标。在背内侧前额叶皮层 (dmPFC) 中，MTPC 后大脑对疼痛预期反应的增加与更高水平的 API 之间存在关联（r=0.77，p＜0.05）。

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引用次数: 0

Neurobiological response to trauma-related and general negative words in men firefighters with post-traumatic stress disorder, compared to trauma-exposed and trauma non-exposed controls: A pilot study 与创伤暴露和非创伤暴露对照组相比，创伤后应激障碍男性消防员对创伤相关和一般负面词汇的神经生物学反应：一项初步研究。

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Psychiatry Research: Neuroimaging

Pub Date : 2024-12-07 DOI: 10.1016/j.pscychresns.2024.111940

Ji Sun Hong , Da Young Lee , Minyoung Sim , Doug Hyun Han

Although firefighters frequently encounter various traumatic incidents, few develop posttraumatic stress disorder (PTSD). In this pilot study, we aimed to examine trauma-specific neurobiological alterations in firefighters with PTSD, distinguishing these characteristics from those of trauma-exposed controls. Twenty-two firefighters (11 firefighters with PTSD and 11 trauma-exposed controls) and 25 trauma non-exposed controls completed psychiatric questionnaires and functional magnetic resonance imaging while engaging in a trauma-specific emotional counting Stroop task for firefighters. In response to general negative words, the firefighter group exhibited increased brain activity in the left and right superior parietal lobes, left cingulate gyrus, and right medial frontal gyrus compared to the trauma non-exposed control group. In response to trauma-related words, the firefighter group displayed increased brain activity in the left and right superior parietal lobes, left and right middle temporal gyri, and precuneus compared to the trauma non-exposed control group. In response to general negative words, firefighters with PTSD exhibited increased brain activity in the right and left middle temporal gyri compared to trauma-exposed controls. In response to trauma-related words, firefighters with PTSD displayed decreased brain activity in the right and left middle frontal gyri compared to trauma-exposed controls. Among firefighters with PTSD, brain activity in the left middle frontal gyrus in response to trauma-related words negatively correlated with the Clinician-Administered PTSD Scale total score. Collectively, firefighters with PTSD demonstrate reduced brain activation within the middle frontal gyrus in response to trauma-related words, indicating a compromised top-down control mechanism.

尽管消防员经常遇到各种创伤事件，但很少有消防员会患上创伤后应激障碍（PTSD）。在这项初步研究中，我们旨在检查创伤后应激障碍消防员的创伤特异性神经生物学改变，将这些特征与创伤暴露对照组区分开来。22名消防员（11名患有创伤后应激障碍的消防员和11名创伤暴露的对照组）和25名创伤未暴露的对照组在参与消防员创伤特异性情绪计数Stroop任务时完成了精神病学问卷和功能磁共振成像。在对一般负面词汇的反应中，消防员组的左、右顶叶上叶、左扣带回和右内侧额回的大脑活动比创伤未暴露的对照组增加。与未接触创伤的对照组相比，消防员组的左、右顶叶上叶、左、右颞中回和楔前叶的大脑活动有所增加。在对一般负面词汇的反应中，与创伤暴露的对照组相比，患有创伤后应激障碍的消防员在左右颞中回表现出更高的大脑活动。在对创伤相关词汇的反应中，与创伤暴露的对照组相比，患有创伤后应激障碍的消防员右侧和左侧额叶中回的大脑活动减少。在患有创伤后应激障碍的消防员中，左额中回脑活动对创伤相关词汇的反应与PTSD量表总分呈负相关。总的来说，患有创伤后应激障碍的消防员在面对与创伤有关的词语时，前额中回的大脑活动减少，表明自上而下的控制机制受损。

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引用次数: 0

Functional connectivity density of postcentral gyrus predicts rumination and major depressive disorders in males 中脑后回功能连接密度预测男性反刍和重度抑郁症。

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Psychiatry Research: Neuroimaging

Pub Date : 2024-12-06 DOI: 10.1016/j.pscychresns.2024.111939

Qiuyao Fan , Haobo Zhang

Major depressive disorder (MDD) is characterized by persistent sadness and loss of interest. Recent evidence suggested that abnormal functional connectivity (FC) may be linked to the development of MDD, and gender differences existed in FC patterns. In this study, we utilized resting-state functional magnetic resonance imaging (RS-fMRI) data from 41 healthy participants to identify FC patterns that correlate with levels of rumination in both genders. A 2-sample t-test showed no gender differences in rumination levels. A functional connectivity density (FCD) analysis was then conducted using DPABI. It was revealed that in males, the FCD of the postcentral gyrus (PCG) was negatively correlated with the levels of rumination and brooding (Pearson's r > 0.25), while not with reflection. No FCD in females was related to rumination or its subtypes. Further FC analysis revealed that the FC between the PCG and several regions, predominantly from the default mode network (DMN), were negatively correlated with rumination levels (Pearson's r > 0.25). This link was assumed to be a risk factor for rumination and MDD in males. In conclusion, our findings indicate that the PCG-DMN connectivity is a potential risk factor for MDD in males, while no FC risk factors were found in females.

重度抑郁症（MDD）的特征是持续的悲伤和兴趣的丧失。最近的证据表明，异常功能连接（FC）可能与MDD的发展有关，并且FC模式存在性别差异。在这项研究中，我们利用来自41名健康参与者的静息状态功能磁共振成像（RS-fMRI）数据来识别两性中与反刍水平相关的FC模式。双样本t检验显示反刍水平无性别差异。然后使用dpai进行功能连接密度（FCD）分析。结果表明，雄鼠中央后回（PCG） FCD与反刍和沉思水平呈负相关（Pearson’s r = 0.25），而与反思水平无显著相关性。女性FCD与反刍及其亚型无相关性。进一步的FC分析显示，PCG与多个区域（主要来自默认模式网络（DMN））之间的FC与反刍水平呈负相关（Pearson’s r = 0.25）。这种联系被认为是男性反刍和重度抑郁症的危险因素。总之，我们的研究结果表明，PCG-DMN连通性是男性MDD的潜在危险因素，而在女性中没有发现FC危险因素。

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引用次数: 0

Neuroimaging findings of adolescent depression: A review by the Research Domain Criteria (RDoC) framework 青少年抑郁症的神经影像学发现：研究领域标准（RDoC）框架的回顾。

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Psychiatry Research: Neuroimaging

Pub Date : 2024-12-05 DOI: 10.1016/j.pscychresns.2024.111917

Harim Jeong , Tianqi Luo , Minjoo Kang , William Frederick Garvey , George Blankenau , Ji-Woo Suk , Mohadese Tarzaben , Soonjo Hwang

This review examines neuroimaging studies on adolescent depression (AD) within the Research Domain Criteria (RDoC) framework, focusing on fMRI, DTI, and EEG findings. The research highlights disrupted connectivity in several neural networks—such as the affective, reward processing, cognitive control, and default mode networks—that underpin emotional and cognitive dysfunctions in AD. Notably, hypoconnectivity in the affective and cognitive control networks correlates with deficits in emotional processing and executive functioning, while hyperactivity in the default mode network relates to excessive self-referential thoughts. Additionally, blunted reward responses and frontal–striatal connectivity are discussed alongside the therapeutic potential of cognitive behavioral therapy (CBT) to modulate these dysfunctional circuits. Despite these insights, variability in findings due to small sample sizes and diverse methodologies suggests a need for further research to validate neuroimaging biomarkers for treatment efficacy and to explore less studied treatments like ECT and TMS in this population. This review underscores the importance of integrating neuroimaging findings to enhance understanding and treatment of AD.

本文回顾了在研究领域标准（RDoC）框架下对青少年抑郁症（AD）的神经影像学研究，重点是fMRI、DTI和EEG的发现。该研究强调了几个神经网络的连接中断，如情感、奖励处理、认知控制和默认模式网络，这些网络是AD患者情绪和认知功能障碍的基础。值得注意的是，情感和认知控制网络的低连通性与情绪处理和执行功能的缺陷有关，而默认模式网络的过度活跃与过度的自我参照思想有关。此外，迟钝的奖励反应和额纹状体连通性与认知行为疗法（CBT）调节这些功能失调回路的治疗潜力一起被讨论。尽管有这些见解，由于样本量小和方法多样，结果的可变性表明需要进一步研究来验证神经成像生物标志物的治疗效果，并探索研究较少的治疗方法，如ECT和TMS在这一人群中。这篇综述强调了整合神经影像学结果对增强对阿尔茨海默病的理解和治疗的重要性。

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引用次数: 0