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Oxyresveratrol modulates the immune response in vitro 白藜芦醇对体外免疫反应的调节作用
IF 0.4 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2021-01-01 DOI: 10.1515/pteridines-2020-0029
S. S. Palabiyik-Yucelik, Simone Moser, K. Becker, Z. Halıcı, Y. Bayir, Marlies Stonig, H. Schennach, D. Fuchs, J. Gostner, K. Kurz
Abstract The naturally occurring stilbenoid oxyresveratrol was shown to influence inflammatory and metabolic processes. During cellular immune activation, tryptophan breakdown and neopterin formation via the enzymes indoleamine 2,3-dioxygenase-1 (IDO-1) and GTP-cyclohydrolase, respectively, are induced. Neopterin and the kynurenine to tryptophan ratio are reliable and pertinent biomarkers of Th1-type immune response and are also used in vitro to monitor effects of active plant ingredients on peripheral blood mononuclear cells (PBMCs). We investigated the effects of oxyresveratrol on the activity of the above-mentioned pathways in mitogen-stimulated human PBMC and in the myelomonocytic cell line THP-1. Oxyresveratrol exerted suppressive effects on tryptophan breakdown in both stimulated cell models. Of note, in PBMC, tryptophan breakdown was induced at lower concentrations (5–20 µM) and suppressed at higher treatment concentrations only. Neopterin formation was decreased dose-dependently in stimulated PBMC. In unstimulated PBMC similar, albeit lesser effects were observed. Data indicate that oxyresveratrol exerts distinct and concentration-dependent effects on different immune cell types. IDO-1 is targeted by oxyresveratrol and its activity can be modulated in both directions. Detailed investigations of the interactions would be interesting to fully explore the activity of this phytocompound.
摘要天然存在的己烯类羟基白藜芦醇对炎症和代谢过程有影响。在细胞免疫激活过程中,分别通过吲哚胺2,3-双加氧酶-1(IDO-1)和GTP环水解酶诱导色氨酸分解和新蝶呤形成。新蝶呤和犬尿氨酸与色氨酸的比例是Th1型免疫反应的可靠和相关的生物标志物,也可在体外用于监测活性植物成分对外周血单核细胞(PBMC)的影响。我们研究了氧白藜芦醇对有丝分裂原刺激的人PBMC和骨髓单核细胞系THP-1中上述途径活性的影响。在两种刺激的细胞模型中,氧白藜芦醇对色氨酸的分解都有抑制作用。值得注意的是,在PBMC中,色氨酸在较低浓度(5-20 µM),并且仅在更高的处理浓度下被抑制。在受刺激的PBMC中,新蝶呤的形成呈剂量依赖性降低。在未刺激的PBMC中观察到类似的,尽管效果较小。数据表明,羟基白藜芦醇对不同类型的免疫细胞具有不同的浓度依赖性作用。IDO-1被羟基白藜芦醇靶向,其活性可以双向调节。对相互作用的详细研究将有助于充分探索这种植物化合物的活性。
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引用次数: 1
Norepinephrine was superior in death risk reducing and hemodynamics compared to dopamine in treatment of patients with septic shock 在脓毒性休克患者的治疗中,去甲肾上腺素在降低死亡风险和血流动力学方面优于多巴胺
IF 0.4 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2021-01-01 DOI: 10.1515/pteridines-2021-0002
Xudong Lu, Xianghua Xu, Yue-e Wu
Abstract Background To investigate the clinical effects of norepinephrine versus dopamine in treatment of septic shock by pooling the data form open published clinical trials. Material and Methods The clinical trials relevant to norepinephrine versus dopamine in treatment of septic shock were electronically searched in the databases of Pubmed, Embase, the Cochrane Library, Web of Science, Google scholar and CNKI. The original data related to the treatment effects such as death risk, oxygen metabolism and hemodynamics index were extracted from the included original studies. The death risk was pooled by the effect size of relative risk (RR), the oxygen metabolism and hemodynamics index were pooled by standard mean difference (SMD) and the corresponding 95% confidence interval (95%CI). The publication bias was evaluated by Begg's funnel plot and Egger's line regression test. Results Thirteen clinical trials were included in the meta-analysis. The pooled results demonstrated the death risk was significantly decreased (RR=0.89, 95%CI:0.81 to 0.98, p=0.024) in septic shock patients who received norepinephrine compared to those receiving dopamine. The HR (SMD=−1.84, 95%CI: −2.86 to −0.81, p<0.01) and cardiac index (SMD=−0.74, 95%CI: −1.01 to −0.48, p<0.01) were lower in norepinephrine group compared to dopamine group. The systemic vascular resistance index (SMD=1.33, 95%CI:0.62 to 2.04, p<0.01) in norepinephrine group was higher than those of dopamine group with statistical difference. The Begg's funnel plot and Egger's line regression test (t=−0.84, p=0.425) showed no publication bias. Conclusions Based on the present evidence, norepinephrine was superior to dopamine in the aspects of death risk reducing and hemodynamics.
背景:通过收集公开发表的临床试验数据,探讨去甲肾上腺素与多巴胺治疗感染性休克的临床效果。材料与方法电子检索Pubmed、Embase、Cochrane Library、Web of Science、谷歌scholar、中国知网等数据库中去甲肾上腺素与多巴胺治疗感染性休克的相关临床试验。从纳入的原始研究中提取与治疗效果相关的原始数据,如死亡风险、氧代谢和血流动力学指标。采用相对危险度效应大小(RR)合并死亡风险,采用标准均差(SMD)和相应的95%可信区间(95% ci)合并氧代谢和血流动力学指标。采用Begg’s漏斗图和Egger’s直线回归检验评价发表偏倚。结果meta分析纳入13项临床试验。综合结果显示,与接受多巴胺治疗的患者相比,接受去甲肾上腺素治疗的脓毒性休克患者的死亡风险显著降低(RR=0.89, 95%CI:0.81至0.98,p=0.024)。去甲肾上腺素组的HR (SMD= - 1.84, 95%CI: - 2.86 ~ - 0.81, p<0.01)和心脏指数(SMD= - 0.74, 95%CI: - 1.01 ~ - 0.48, p<0.01)低于多巴胺组。去甲肾上腺素组全身血管阻力指数(SMD=1.33, 95%CI:0.62 ~ 2.04, p<0.01)高于多巴胺组,差异有统计学意义。Begg's漏斗图和Egger's直线回归检验(t= - 0.84, p=0.425)显示无发表偏倚。结论根据目前的证据,去甲肾上腺素在降低死亡风险和血流动力学方面优于多巴胺。
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引用次数: 0
Screening and bioinformatics analysis of key biomarkers in acute myocardial infarction 急性心肌梗死关键生物标志物的筛选及生物信息学分析
IF 0.4 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2021-01-01 DOI: 10.1515/pteridines-2020-0031
Dongmei Wei, Rui Li, Tao Si, Hankang He, Wei Wu
Abstract Acute myocardial infarction (AMI) is the most severe manifestation of coronary artery disease. Considerable efforts have been made to elucidate its etiology and pathology, but the genetic factors that play a decisive role in the occurrence of AMI are still unclear. To determine the molecular mechanism of the occurrence and development of AMI, four microarray datasets, namely, GSE29111, GSE48060, GSE66360, and GSE97320, were downloaded from the Gene Expression Omnibus (GEO) database. We analyzed the four GEO datasets to obtain the differential expression genes (DEGs) of patients with AMI and patients with non-AMI and then performed gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, and Protein-protein interaction (PPI) network analysis. A total of 41 DEGs were identified, including 39 upregulated genes and 2 downregulated genes. The enriched functions and pathways of the DEGs included the inflammatory response, neutrophil chemotaxis, immune response, extracellular space, positive regulation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) transcription factor activity, response to lipopolysaccharide, receptor for advanced glycation end products (RAGE) receptor binding, innate immune response, defense response to bacterium, and receptor activity. The cytoHubba plug-in in Cytoscape was used to select the most significant hub gene from the PPI network. Ten hub genes were identified, and GO enrichment analysis revealed that these genes were mainly enriched in inflammatory response, neutrophil chemotaxis, immune response, RAGE receptor binding, and extracellular region. In conclusion, this study integrated four datasets and used bioinformatics methods to analyze the gene chips of AMI samples and control samples and identified DEGs that may be involved in the occurrence and development of AMI. The study provides reliable molecular biomarkers for AMI screening, diagnosis, and prognosis.
摘要急性心肌梗死(AMI)是冠状动脉疾病最严重的表现。人们已经做出了相当大的努力来阐明其病因和病理,但在AMI发生中起决定性作用的遗传因素仍不清楚。为了确定AMI发生和发展的分子机制,从基因表达综合数据库(GEO)下载了四个微阵列数据集,即GSE29111、GSE48060、GSE66360和GSE97320。我们分析了四个GEO数据集,以获得AMI患者和非AMI患者的差异表达基因(DEG),然后进行了基因本体论(GO)、京都基因和基因组百科全书(KEGG)富集分析和蛋白质-蛋白质相互作用(PPI)网络分析。共鉴定出41个DEG,包括39个上调基因和2个下调基因。DEGs的丰富功能和途径包括炎症反应、中性粒细胞趋化性、免疫反应、细胞外空间、活化B细胞核因子κ轻链增强子(NF-κB)转录因子活性的正调控、对脂多糖的反应、晚期糖基化终产物受体(RAGE)受体结合、先天免疫反应,对细菌的防御反应和受体活性。Cytoscape中的cytoHubba插件用于从PPI网络中选择最重要的枢纽基因。鉴定出10个hub基因,GO富集分析显示,这些基因主要富集在炎症反应、中性粒细胞趋化性、免疫反应、RAGE受体结合和细胞外区域。总之,本研究整合了四个数据集,并使用生物信息学方法分析了AMI样本和对照样本的基因芯片,确定了可能参与AMI发生和发展的DEG。该研究为AMI的筛查、诊断和预后提供了可靠的分子生物标志物。
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引用次数: 3
Lipophilic vs. hydrophilic statins and psychiatric hospitalizations and emergency room visits in US Veterans with schizophrenia and bipolar disorder. 亲脂与亲水他汀类药物与精神分裂症和双相情感障碍美国退伍军人的精神住院和急诊室就诊
IF 0.4 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2021-01-01 Epub Date: 2021-09-23 DOI: 10.1515/pteridines-2020-0028
Teodor T Postolache, Deborah R Medoff, Clayton H Brown, Li Juan Fang, Sanjaya K Upadhyaya, Christopher A Lowry, Michael Miller, Julie A Kreyenbuhl

Objective –: Psychiatric hospitalizations and emergency department (ED) visits are costly, stigmatizing, and often ineffective. Given the immune and kynurenine activation in bipolar disorder (BD) and schizophrenia, as well as the immune-modulatory effects of statins, we aimed to compare the relative risk (RRs) of psychiatric hospitalizations and ED visits between individuals prescribed lipophilic vs. hydrophilic statins vs. no statins. We hypothesized (a) reduced rates of hospitalization and ER utilization with statins versus no statins and (b) differences in outcomes between statins, as lipophilia increases the capability to penetrate the blood-brain barrier with potentially beneficial neuroimmune, antioxidant, neuroprotective, neurotrophic, and endothelial stabilizing effects, and, in contrast, potentially detrimental decreases in brain cholesterol concentrations leading to serotoninergic dysfunction, changes in membrane lipid composition, thus affecting ion channels and receptors.

Methods –: We used VA service utilization data from October 1, 2010 to September 30, 2015. The RRs for psychiatric hospitalization and ED visits, were estimated using robust Poisson regression analyses. The number of individuals analyzed was 683,129.

Results –: Individuals with schizophrenia and BD who received prescriptions for either lipophilic or hydrophilic statins had a lower RR of psychiatric hospitalization or ED visits relative to nonstatin controls. Hydrophilic statins were significantly associated with lower RRs of psychiatric hospitalization but not of ED visits, compared to lipophilic statins.

Conclusion –: The reduction in psychiatric hospitalizations in statin users (vs. nonusers) should be interpreted cautiously, as it carries a high risk of confounding by indication. While the lower RR of psychiatric hospitalizations in hydrophilic statins relative to the lipophilic statins is relatively bias free, the finding bears replication in a specifically designed study. If replicated, important clinical implications for personalizing statin treatment in patients with mental illness, investigating add-on statins for improved therapeutic control, and mechanistic exploration for identifying new treatment targets are natural next steps.

目的:精神科住院和急诊科(ED)就诊是昂贵的,污名化的,往往是无效的。考虑到双相情感障碍(BD)和精神分裂症的免疫和犬尿氨酸激活,以及他汀类药物的免疫调节作用,我们的目的是比较服用亲脂、亲水和非他汀类药物的个体在精神病住院和ED就诊的相对风险(rr)。我们假设(a)与不使用他汀类药物相比,他汀类药物的住院率和ER利用率降低;(b)他汀类药物之间的结果差异,因为嗜脂性增加了穿透血脑屏障的能力,具有潜在的有益的神经免疫、抗氧化、神经保护、神经营养和内皮稳定作用,相反,潜在的有害的脑胆固醇浓度降低导致血清素功能障碍。改变膜脂组成,从而影响离子通道和受体。方法:我们使用2010年10月1日至2015年9月30日的VA服务利用数据。使用稳健泊松回归分析估计精神科住院和急诊科就诊的rr。分析的个体数量为683,129。结果:与非他汀类药物对照组相比,接受亲脂或亲水他汀类药物处方的精神分裂症和双相障碍患者精神病住院或急诊科就诊的RR较低。与亲脂他汀类药物相比,亲水他汀类药物与精神病住院的低rr显著相关,但与急诊科就诊无关。结论:他汀类药物服用者(与非服用者相比)精神病住院率的降低应谨慎解释,因为它具有较高的适应症混淆风险。虽然亲水他汀类药物相对于亲脂他汀类药物的精神病住院风险相对较低,但这一发现需要在一项专门设计的研究中得到证实。如果实验成功,那么对精神疾病患者个性化他汀类药物治疗的重要临床意义,研究他汀类药物的附加治疗控制,以及确定新的治疗靶点的机制探索将是自然的下一步。
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引用次数: 3
Clinical significance of serum homocysteine as a biomarker for early diagnosis of diabetic nephropathy in type 2 diabetes mellitus patients 血清同型半胱氨酸作为2型糖尿病肾病早期诊断的生物标志物的临床意义
IF 0.4 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2021-01-01 DOI: 10.1515/pteridines-2020-0025
B. Ye, Xiangying Zhu, Zhifu Zeng, Xiaozhen Ji, Mei-Jing Ji
Abstract Objective The aim of this study was to investigate the clinical significance of serum homocysteine (Hcy) as a biomarker for early diagnosis of diabetic nephropathy (DN) in type 2 diabetes mellitus (T2DM) patients. Methods Fifty-five T2DM patients with DN and 51 T2DM patients without DN were prospectively recruited from January 2016 to May 2020 in our hospital. The serum Hcy was tested by electrochemiluminescence assay in DN and T2DM groups and compared. The diagnostic efficacy of serum Hcy as a biomarker for early diagnosis of DN was evaluated by calculating the diagnostic sensitivity, specificity and area under the ROC curve (AUC). Results The serum levels of Hcy were 15.49 ± 5.40 and 9.23 ± 3.15 μmol/L for DN and T2DM patients, respectively, with statistical difference (t = 7.21, P < 0.001). In the DN group, the serum Hcy levels for patients with hyperfiltration, intermittent proteinuria, microalbuminuria, macroalbuminuria and uremic were 10.99 ± 2.57, 13.90 ± 2.86, 15.38 ± 4.77, 18.98 ± 4.36 and 23.31 ± 5.22 μmol/L, respectively, which indicated that serum Hcy levels in DN were higher than those of T2DM patients and correlated with patient’s renal damage. Using the serum Hcy level as the reference, the diagnostic sensitivity, specificity and AUC were 84.31 (71.41–92.98)%, 74.55 (61.00–85.33)% and 0.85 (0.78–0.92)%, respectively, with the cutoff value of 12.08 between DN and T2DM. The serum Hcy also had relatively good differential diagnostic efficacy between different DN stages with high sensitivity, specificity and AUC. Conclusion Serum Hcy was obviously elevated in DN compared to T2MD and correlated with the renal damage severity, which can be applied as a potential serological marker for early diagnosis of DN.
摘要目的探讨血清同型半胱氨酸(Hcy)作为2型糖尿病(T2DM)患者糖尿病肾病(DN)早期诊断的生物标志物的临床意义。方法前瞻性招募2016年1月~ 2020年5月我院合并DN的T2DM患者55例,非DN的T2DM患者51例。采用电化学发光法检测DN组和T2DM组血清Hcy水平,并进行比较。通过计算诊断敏感性、特异性和ROC曲线下面积(AUC)来评价血清Hcy作为早期诊断DN的生物标志物的诊断效果。结果DN、T2DM患者血清Hcy水平分别为15.49±5.40、9.23±3.15 μmol/L,差异有统计学意义(t = 7.21, P < 0.001)。DN组高滤过、间歇性蛋白尿、微量白蛋白尿、大量白蛋白尿和尿毒症患者血清Hcy水平分别为10.99±2.57、13.90±2.86、15.38±4.77、18.98±4.36和23.31±5.22 μmol/L,提示DN患者血清Hcy水平高于T2DM患者,且与患者肾损害相关。以血清Hcy水平为参考,诊断敏感性为84.31(71.41 ~ 92.98)%,特异性为74.55 (61.00 ~ 85.33)%,AUC为0.85 (0.78 ~ 0.92)%,DN与T2DM的临界值为12.08。血清Hcy在不同DN分期间也有较好的鉴别诊断效果,具有较高的敏感性、特异性和AUC。结论与T2MD相比,DN患者血清Hcy明显升高,且与肾损害程度相关,可作为DN早期诊断的潜在血清学指标。
{"title":"Clinical significance of serum homocysteine as a biomarker for early diagnosis of diabetic nephropathy in type 2 diabetes mellitus patients","authors":"B. Ye, Xiangying Zhu, Zhifu Zeng, Xiaozhen Ji, Mei-Jing Ji","doi":"10.1515/pteridines-2020-0025","DOIUrl":"https://doi.org/10.1515/pteridines-2020-0025","url":null,"abstract":"Abstract Objective The aim of this study was to investigate the clinical significance of serum homocysteine (Hcy) as a biomarker for early diagnosis of diabetic nephropathy (DN) in type 2 diabetes mellitus (T2DM) patients. Methods Fifty-five T2DM patients with DN and 51 T2DM patients without DN were prospectively recruited from January 2016 to May 2020 in our hospital. The serum Hcy was tested by electrochemiluminescence assay in DN and T2DM groups and compared. The diagnostic efficacy of serum Hcy as a biomarker for early diagnosis of DN was evaluated by calculating the diagnostic sensitivity, specificity and area under the ROC curve (AUC). Results The serum levels of Hcy were 15.49 ± 5.40 and 9.23 ± 3.15 μmol/L for DN and T2DM patients, respectively, with statistical difference (t = 7.21, P < 0.001). In the DN group, the serum Hcy levels for patients with hyperfiltration, intermittent proteinuria, microalbuminuria, macroalbuminuria and uremic were 10.99 ± 2.57, 13.90 ± 2.86, 15.38 ± 4.77, 18.98 ± 4.36 and 23.31 ± 5.22 μmol/L, respectively, which indicated that serum Hcy levels in DN were higher than those of T2DM patients and correlated with patient’s renal damage. Using the serum Hcy level as the reference, the diagnostic sensitivity, specificity and AUC were 84.31 (71.41–92.98)%, 74.55 (61.00–85.33)% and 0.85 (0.78–0.92)%, respectively, with the cutoff value of 12.08 between DN and T2DM. The serum Hcy also had relatively good differential diagnostic efficacy between different DN stages with high sensitivity, specificity and AUC. Conclusion Serum Hcy was obviously elevated in DN compared to T2MD and correlated with the renal damage severity, which can be applied as a potential serological marker for early diagnosis of DN.","PeriodicalId":20792,"journal":{"name":"Pteridines","volume":"32 1","pages":"11 - 16"},"PeriodicalIF":0.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/pteridines-2020-0025","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44481272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
The urinary biopterin in autism spectrum disorder 自闭症谱系障碍中的尿生物蝶呤
IF 0.4 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2021-01-01 DOI: 10.1515/pteridines-2020-0023
A. Waligóra, A. Damasiewicz-Bodzek, P. Gorczyca, Sławomir Waligóra, K. Tyrpień-Golder
Abstract Objective The aim of the study was to determine whether biopterin is present in significantly lower quantities in urine samples of patients with autism spectrum disorder (ASD) compared to healthy individuals. Methods The concentration of biopterin in urine samples was measured by ELISA using commercially available kit. The study involved 53 children aged 3–16 years with ASD and 60 healthy children aged 2–14 years. Results Significantly lower biopterin concentration was observed in autistic patients compared to the control group. However, no significant difference was observed between mild, moderate, and severe ASD. Conclusion One of the potential causes of decrease in urinary biopterin levels may be tetrahydrobiopterin (BH4) deficiency, which has extensive and serious health consequences for the nervous system. The results of measuring biopterin as a fully oxidized form of BH4 may suggest that biosynthesis or regeneration of BH4 may be decreased in children with ASD. On the other hand, decreased urinary biopterin levels in children with ASD may be due to BH4 overuse, a good regeneration process, and decreased urinary excretion; and abnormalities in BH4 metabolism appear to be related to the aetiology of ASD or may be due to ASD.
【摘要】目的研究自闭症谱系障碍(ASD)患者尿液样本中生物蝶呤的含量是否明显低于健康人群。方法采用市售试剂盒,采用酶联免疫吸附法测定尿标本中生物蝶呤的浓度。这项研究涉及53名年龄在3-16岁的自闭症儿童和60名年龄在2-14岁的健康儿童。结果自闭症患者的生物蝶呤浓度明显低于对照组。然而,在轻度、中度和重度ASD之间没有观察到显著差异。结论四氢生物蝶呤(BH4)缺乏可能是尿中生物蝶呤水平下降的潜在原因之一,它对神经系统具有广泛而严重的健康后果。测量生物蝶呤作为BH4的完全氧化形式的结果可能表明,ASD儿童BH4的生物合成或再生可能减少。另一方面,ASD患儿尿中生物蝶呤水平下降可能与BH4过度使用、再生过程良好、尿排泄减少有关;BH4代谢异常似乎与ASD的病因有关或可能由ASD引起。
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引用次数: 0
Correlation between methylene tetrahydrofolate reductase (MTHFR) gene rs1801133 C>T polymorphisms and risk of osteoporosis 亚甲基四氢叶酸还原酶基因rs1801133 C>T多态性与骨质疏松症风险的相关性
IF 0.4 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2021-01-01 DOI: 10.1515/pteridines-2020-0035
Xiao Chen, Weiran Zhang, Jingmin Huang
Abstract Objective To evaluate the correlation between methylene tetrahydrofolate reductase (MTHFR) gene rs1801133 C>T polymorphisms and risk of osteoporosis. Methods We searched the clinical studies related to MTHFR gene rs1801133 C>T polymorphisms and risk of osteoporosis in the electronic databases of PubMed, Web of Science, EMBASE, China National Knowledge Infrastructure (CNKI), Chinese BioMedical Literature Database (CBM) and included the suitable publications in the present meta-analysis according to the inclusion and exclusion criteria. The data of included studies were extracted and pooled by a random or fixed-effect model. The odds ratio (OR) and 95% confidence interval (95% CI) were applied to demonstrate the correlation between MTHFR gene rs1801133 C>T polymorphisms and the risk of osteoporosis. Publication bias was assessed by Begg’s funnel plot and Egger’s line regression test. Results Seven case–control clinical studies were included and a data combination was made. The data was pooled by the fixed effect model because of no obvious statistical heterogeneity. The pooled results indicated that people with the T allele had increased risk of developing osteoporosis under the homologous gene model (TT vs CC) (OR = 2.36, 95% CI: 1.81–3.08, p < 0.05), dominant gene model (TT + CT) vs CC (OR = 1.47, 95% CI: 1.21–1.77, p < 0.05) and recessive gene model TT vs (CC + CT) (OR = 2.16, 95% CI: 1.71–2.74, p < 0.05). Egger’s line regression test indicated no significant publication bias for the present meta-analysis in the above homologous, dominant, and recessive gene models. Conclusion The MTHFR gene rs1801133 C>T polymorphisms are associated with osteoporosis and subjects with the T allele have an increased risk of developing osteoporosis.
【摘要】目的探讨亚甲基四氢叶酸还原酶(MTHFR)基因rs1801133 C >t多态性与骨质疏松风险的相关性。方法在PubMed、Web of Science、EMBASE、中国知网(CNKI)、中国生物医学文献数据库(CBM)等电子数据库中检索MTHFR基因rs1801133 C bbbbt多态性与骨质疏松风险相关的临床研究,并根据纳入和排除标准将合适的文献纳入本meta分析。纳入研究的数据通过随机或固定效应模型提取和汇总。应用比值比(OR)和95%置信区间(95% CI)验证MTHFR基因rs1801133 C >t多态性与骨质疏松风险的相关性。采用Begg’s漏斗图和Egger’s直线回归检验评价发表偏倚。结果纳入7项病例对照临床研究,并进行资料组合。由于没有明显的统计异质性,数据采用固定效应模型进行合并。结果表明,同源基因模型(TT vs CC)、显性基因模型(TT + CT) vs CC (OR = 1.47, 95% CI: 1.21-1.77, p < 0.05)、隐性基因模型(TT vs CC + CT) (OR = 2.16, 95% CI: 1.71-2.74, p < 0.05)下携带T等位基因的人发生骨质疏松的风险增加。Egger 's线回归检验表明,在上述同源、显性和隐性基因模型中,本meta分析没有显著的发表偏倚。结论MTHFR基因rs1801133 C b> T多态性与骨质疏松症相关,携带该T等位基因的受试者骨质疏松症发生风险增加。
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引用次数: 0
Effect of Folate-deficient Diet and 5-Fluorouracil Treatment In the zn VlVO Model of Mice L1210 Leukemia 叶酸缺乏饮食和5-氟尿嘧啶治疗对L1210白血病小鼠zn - VlVO模型的影响
IF 0.4 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2020-05-26 DOI: 10.1515/pteridines.1994.5.3.107
Julita Graczyk
SummaryThe present study investigated the effect of reduced folic acid content in the organism, due to deficient diet, on the survival time of mice with L1210 leukemia, treated with fluorouracil. One of the mechanisms of the cytotoxic effect of fluorouracil is the inhibition of thymidylate synthase by binding fluorodeoxyuridylate, a 5-fluorouracil metabolite. Tetrahydrofoliane factor, for which folic acid is the substrate, takes part in this process. From the presented study it follows that the synthetic diet prepared without the addition of folic acid caused significantly lower blood serum folic acid levels, reduction of vitamin Bl2 level, anemia, as well as lowered leukocyte count. The antineoplastic effect of fluorouracil on L1210 leukemia was in that group of mice weaker than the effect of fluorouracil in mice receiving synthetic diet which met their folic acid requirement.
本研究探讨了饮食不足导致机体内叶酸含量降低对氟脲嘧啶治疗L1210白血病小鼠存活时间的影响。氟尿嘧啶细胞毒性作用的机制之一是通过结合5-氟尿嘧啶代谢物氟脱氧尿苷酸抑制胸苷酸合成酶。以叶酸为底物的四氢叶烷因子参与了这一过程。本研究表明,不添加叶酸的合成饲粮可显著降低血清叶酸水平,降低维生素b2水平,导致贫血和白细胞计数降低。氟尿嘧啶对L1210白血病的抗肿瘤作用在该组小鼠中弱于在满足叶酸需求的合成饲料小鼠中氟尿嘧啶的作用。
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引用次数: 0
Tryptophan metabolism, stress and feather pecking in domestic chickens 家鸡色氨酸代谢、应激与羽毛啄食
IF 0.4 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2020-02-25 DOI: 10.1515/PTERIDINES-2020-0018
C. Mindus, N. Staaveren, P. Forsythe, S. Geisler, J. Gostner, J. Kjaer, W. Kunze, A. Shoveller, D. Fuchs, A. Harlander
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引用次数: 1
Inflammation, iron and vitamin D metabolism in different cardiomyopathy aetiologies 炎症、铁和维生素D代谢在不同心肌病病因中的作用
IF 0.4 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2020-01-01 DOI: 10.1515/pteridines-2020-0004
Lukas Lanser, Nada Nemati, M. Seifert, D. Fuchs, G. Weiss, G. Pölzl, K. Kurz
Abstract Immune activation coincides with disturbances in iron and vitamin D metabolism in patients with cardiomyopathy. In this study, we investigated whether there are differences regarding immune activation, iron and vitamin D metabolism between the different cardiomyopathy aetiologies. Patients and methods: Parameters of iron metabolism (haemoglobin, iron, transferrin, transferrin saturation, ferritin, hepcidin), vitamin D metabolism (Ct-FGF23, parathormone, phosphate, vitamin D) and immune activation (C-reactive protein and neopterin) were determined in 149 patients (98 men, 51 women) with non-ischaemic cardiomyopathy. Results: Patients with amyloid cardiomyopathy presented with higher neopterin, ferritin and hepcidin levels than other cardiomyopathy aetiologies. Furthermore, they showed the highest rate of cardiovascular events. C-reactive protein levels were significantly higher in patients with inflammatory cardiomyopathy. Patients with virus positive cardiomyopathy presented with significantly higher ferritin and Ct-FGF23 levels compared to patients with virus negative inflammatory cardiomyopathy. Conclusion: This study indicates that there are some differences regarding the extent of immune activation and inflammation as well as alterations in iron metabolism disorders between different cardiomyopathy aetiologies. Further studies with larger patient cohorts are needed to investigate these findings more precisely.
摘要心肌病患者的免疫激活与铁和维生素D代谢紊乱相吻合。在这项研究中,我们调查了不同心肌病病因之间在免疫激活、铁和维生素D代谢方面是否存在差异。患者和方法:测定149名非缺血性心肌病患者(98名男性,51名女性)的铁代谢参数(血红蛋白、铁、转铁蛋白、转铁蛋白饱和度、铁蛋白、铁调素)、维生素D代谢参数(Ct-FGF23、甲状旁腺素、磷酸盐、维生素D)和免疫激活参数(C反应蛋白和新蝶呤)。结果:淀粉样心肌病患者的新蝶呤、铁蛋白和铁调素水平高于其他心肌病病因。此外,他们的心血管事件发生率最高。炎症性心肌病患者的C反应蛋白水平显著升高。与病毒阴性炎症性心肌病患者相比,病毒阳性心肌病患者的铁蛋白和Ct-FGF23水平显著升高。结论:本研究表明,不同病因的心肌病在免疫激活和炎症程度以及铁代谢紊乱方面存在一些差异。需要对更大的患者群体进行进一步的研究,以更准确地调查这些发现。
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Pteridines
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