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Case Report of Congenital Microtia-Atresia 先天性小闭锁1例
Pub Date : 2021-08-01 DOI: 10.32598/qums.15.5.1975.4
M. Alipour, K. Khashei Varnamkhasti
Background and Objectives Microtia-atresia is a rare congenital anomaly, which characterized by a small, abnormally shaped auricle (microtia) accompanied with narrow, blocked or absent ear canal (atresia). Microtia can occur appear either as independent clinical abnormality or as part of a syndrome. Due to hearing loss, 80%–90% of patients are at increasing risk of speech and poor academic performance. This abnormality with genetic predisposition and autosomal dominant or recessive mode of Mendelian hereditary, as well as forms due to chromosomal aberrations, occur in varying degrees from 0.83 to 17.4 per 10,000 births, usually unilateral form with more common in males. Case Presentation In this article, a term male neonate with microtia-atresia, born of a 34-year-old mother, was reported. On initial examination by a pediatrician, not properly formation of external right ear and absence of the ear canal was observed in infant. In a closer examination no craniofacial anomalies and no microtia associated syndrome was not observed.
背景与目的小耳闭锁是一种罕见的先天性畸形,其特征是耳廓小且形状异常(小耳)并伴有耳道狭窄、阻塞或缺失(闭锁)。小体缺失既可以作为独立的临床异常出现,也可以作为综合征的一部分出现。由于听力损失,80%-90%的患者有言语障碍和学习成绩不佳的风险。这种具有遗传易感性和常染色体显性或隐性孟德尔遗传模式的异常,以及由染色体畸变引起的异常,发生率从每10,000个新生儿0.83到17.4不等,通常是单侧形式,在男性中更常见。本文报告了一位34岁母亲所生的足月男婴微闭锁。在儿科医生的初步检查中,观察到婴儿右耳外耳发育不正常,耳道缺失。在更仔细的检查中,没有观察到颅面异常和小脑相关综合征。
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引用次数: 0
The Impact of Educational Intervention Based on Extended Health Belief Model With Social Support on Promoting Self-care Behaviors in Patients With Smear Positive Pulmonary TB 基于社会支持的扩展健康信念模型教育干预对促进涂阳肺结核患者自我保健行为的影响
Pub Date : 2021-08-01 DOI: 10.32598/qums.15.5.1829.1
S. Hosseinalipour, A. Mohammadbeigi, A. Rahbar, S. Mohebi
Background and Objectives: Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. It is the tenth leading cause of death in the world. Despite the implementation of an effective prevention and treatment plan, the expected success in reducing and controlling TB cases has not yet been achieved. The aim of this study was to determine the effect of education based on health belief model developed with social support on the promotion of self-care behaviors of patients with smear-positive pulmonary tuberculosis in Qom province in 2019. Methods: 80 patients with smear-positive pulmonary tuberculosis Patient being treated at Qom Health Center were included in this educational intervention study. Patients were randomly divided into experimental (n= 40) and control (n= 40) groups. The educational intervention was performed in three sessions of 45 minutes. Data were collected using a questionnaire and during a direct interview before the educational intervention and three months after the educational intervention. Data analysis using SPSS software version 20 and descriptive tests (frequency and percentage, mean and standard deviation) and analytical tests (paired t-test, independent t-test and Chi-square) at the significance level of 0.05 done. Results: Before educational intervention, there was no significant difference in the mean scores of self-care behavior, perceived sensitivity, perceived barriers, perceived benefits, perceived self-efficacy and perceived social support between the experimental and control groups (P>0.05 ). However, after the educational intervention, a significant difference was observed between the experimental and control groups in terms of the mean scores of self-care behavior, perceived barriers, perceived benefits, perceived self-efficacy and perceived social support (P<0.05). Conclusion: The results of this study showed that education Based on Extended Health Belief Model can be effective on perceived barriers, perceived benefits, perceived self-efficacy, perceived social support, and self-care by increasing and improving the status of structures. Therefore, by designing educational programs based on this model, it is possible to provide the ground for behavior change in target patients.
背景与目的:结核病是一种由结核分枝杆菌引起的传染病。它是世界上第十大死亡原因。尽管实施了有效的预防和治疗计划,但在减少和控制结核病病例方面尚未取得预期的成功。本研究旨在探讨基于社会支持的健康信念模型教育对2019年库姆省痰阳性肺结核患者自我护理行为的促进作用。方法:对80例涂阳肺结核患者进行教育干预研究。患者随机分为实验组(n= 40)和对照组(n= 40)。教育干预分三次进行,每次45分钟。在教育干预前和教育干预后三个月,通过问卷调查和直接访谈收集数据。数据分析采用SPSS软件20版,在0.05的显著性水平上进行描述性检验(频率和百分比、均值和标准差)和分析性检验(配对t检验、独立t检验和卡方检验)。结果:教育干预前,实验组与对照组在自我护理行为、感知敏感性、感知障碍、感知利益、感知自我效能感、感知社会支持等方面的平均得分差异均无统计学意义(P>0.05)。而教育干预后,实验组与对照组在自我照顾行为、感知障碍、感知利益、感知自我效能和感知社会支持的平均得分均有显著差异(P<0.05)。结论:本研究结果表明,基于扩展健康信念模型的教育可以通过增加和改善结构状态,在感知障碍、感知利益、感知自我效能、感知社会支持和自我照顾方面发挥有效作用。因此,通过设计基于该模型的教育方案,有可能为目标患者的行为改变提供依据。
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引用次数: 4
Antimicrobial Effect of Hydroalcoholic Extracts of Oak Jaft (Quercus Persica) and Echium Amoenum on Shigella Flexneri 栎叶水醇提取物和石斛水醇提取物对福氏志贺氏菌的抑菌作用
Pub Date : 2021-08-01 DOI: 10.32598/qums.15.5.2349.1
Marzieh An'aam, Fatemeh Riyahi Zaniani, Farid Shirmardi Dezaki
Background and Objectives: Today, because of the spread of drug resistance and the prevalence of infectious diseases, the use of medicinal plants has increased. So, in this study, the antibacterial effect of hydroalcoholic extract of Oak jaft and Echium amoenum was investigated on Shigella flexneri. Methods: In this study, hydroalcoholic extracts were extracted by maceration method and concentrated by rotary evaporator then dried immediately. Next, the antimicrobial effect of different dilutions of extracts on Shigella flexneri was investigated by disk diffusion and micro broth dilution methods and compared with two antibiotics, ciprofloxacin and trimethoprim-sulfamethoxazole. Results: The results showed that in proportion to the increase in the concentration of oak jaft extract, its antibacterial effect on Shigella flexneri also increased and 3.9 and 7.8 mg/ml of the extract were obtained by MIC and MBC dilution micro broth method, respectively. In the case of Echium amoenum extract, bacteria were grown at all dilutions (except the main stock of the extract (250 mg/ml)) and the extract had no antimicrobial effect on Shigella flexneri. Conclusion: According to the results of this study, oak jaft extract had a good inhibitory effect on Shigella flexneri and in comparison, with ciprofloxacin antibiotic, a similar inhibitory effect was observed and in comparison, with trimethoprim sulfamethoxazole, more inhibitory effect was observed.
背景与目的:今天,由于耐药性的蔓延和传染病的流行,药用植物的使用增加了。因此,本研究考察了橡树叶和菊苣水醇提取物对福氏志贺氏菌的抑菌作用。方法:采用浸渍法提取水醇提取物,经旋转蒸发器浓缩后立即干燥。其次,采用圆盘扩散法和微肉汤稀释法考察不同稀释度提取物对福氏志贺氏菌的抑菌效果,并与环丙沙星、甲氧苄啶-磺胺甲恶唑两种抗生素进行比较。结果:结果表明,随着浸提液浓度的增加,其对福氏志贺氏菌的抑菌效果也相应增强,MIC和MBC稀释微肉汤法浸提液的抑菌效果分别为3.9和7.8 mg/ml。以紫锥菊提取物为例,除提取物的主要原料(250 mg/ml)外,所有稀释度的细菌都能生长,提取物对福氏志贺氏菌没有抑菌作用。结论:根据本研究结果,橡树叶提取物对福氏志贺氏菌具有良好的抑制作用,与环丙沙星抗生素比较,抑菌效果相近,与甲氧苄啶磺胺甲恶唑比较,抑菌效果更明显。
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引用次数: 0
The Effectiveness of Dialectical Behavioral Therapy on Stress and Cognitive Flexibility in Women With Type 2 Diabetes 辩证行为疗法对女性2型糖尿病患者应激和认知灵活性的影响
Pub Date : 2021-08-01 DOI: 10.32598/qums.15.5.2373.1
Fatemeh Khakshoor Shandiz, F. Shahabizadeh, Qasem Ahi, Mahya Mojahedi
Background and Objectives: Diabetes has irreversible effects on the physical and mental functioning of people with diabetes, therefore performing psychological interventions for patients with diabetes seems necessary. Accordingly, the present study aimed to determine the effectiveness of dialectical behavioral therapy on stress and cognitive flexibility of women with type 2 diabetes. Methods: The present study was a quasi-experimental one with pre-test and post-test design and with a control group. Among the statistical population, which included all women with diabetes referred to the Diabetes Center of Birjand in the second 6 months of 2018, 30 people were selected by convenience sampling method and randomly divided into experimental and control groups. The dialectical behavior therapy program was performed for the experimental group in eight 60-minute sessions weekly. Data were collected by Stress Questionnaire (Lovibond & Lovibond, 1995) and Cognitive Flexibility Questionnaire (Dennis & Wendrew, 2010) before and after the intervention, and were analyzed using univariate and multivariate analysis of covariance in the environment of SPSS v. 24 at a significance level of 0.05. Results: The results showed that in the post-test stage there was a significant difference between mean scores of stress and cognitive flexibility in experimental and control groups; in other words, dialectical behavior therapy significantly increased cognitive flexibility and reduced stress in patients with type 2 diabetes (P<0.01). Conclusion: Based on the obtained results, in the therapeutic interventions of diabetic patients using effective treatment methods such as dialectical behavior therapy, it is necessary to pay more attention to the improvement of their psychological conditions.
背景与目的:糖尿病对糖尿病患者的身心功能具有不可逆转的影响,因此对糖尿病患者进行心理干预似乎是必要的。因此,本研究旨在确定辩证行为疗法对女性2型糖尿病患者压力和认知灵活性的有效性。方法:本研究采用准实验设计,采用前测和后测设计,并设对照组。在统计人群中,包括2018年下半年到Birjand糖尿病中心就诊的所有女性糖尿病患者,采用方便抽样的方法选择30人,随机分为实验组和对照组。实验组每周进行八次60分钟的辩证行为治疗。在干预前后分别采用压力问卷(Lovibond & Lovibond, 1995)和认知灵活性问卷(Dennis & Wendrew, 2010)收集数据,在SPSS v. 24环境下采用单因素和多因素协方差分析,显著性水平为0.05。结果:在测试后阶段,实验组和对照组的压力和认知灵活性平均分存在显著差异;也就是说,辩证行为疗法显著提高了2型糖尿病患者的认知灵活性,降低了患者的应激水平(P<0.01)。结论:基于所获得的结果,在采用辩证行为疗法等有效的治疗方法对糖尿病患者进行治疗干预时,需要更多地关注患者心理状况的改善。
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引用次数: 1
Investigating the Association Between Health Literacy and Quality of Life Among Patients With Heart Failure Hospitalized in Coronary Care Unit at Selected Hospitals in Tehran, Iran 调查伊朗德黑兰选定医院冠心病监护病房住院心力衰竭患者健康素养与生活质量之间的关系
Pub Date : 2021-07-01 DOI: 10.32598/qums.15.4.230
Mehri Abdi, N. Alaee, R. Norouzadeh
Background and Objectives: Symptoms of heart failure and its complications over time cause limitations in the normal life process of patients and may affect their quality of life. Thus, this study aimed to investigate the relationship between health literacy and patients' quality of life with heart failure admitted to the intensive care units in selected hospitals in Tehran City, Iran. Methods: In this study, 105 patients with heart failure were selected. They were admitted to the cardiac ICU in educational hospitals in Tehran. Data collection tools were demographic information, heart failure health literacy, and quality of life questionnaires. Descriptive statistics and statistical methods of correlation and regression were performed using SPSS v. 24. Results: The results showed a significant positive relationship (r= 0.40) between health literacy and quality of life scores in patients with heart failure. Also, health literacy significantly predicted the quality of life score in patients with heart failure (P<0.001). The results of bivariate regression analysis showed that health literacy scores significantly predict the quality of life of patients with heart failure (P<0.001, r2= 0.16). Conclusion: The findings showed that health literacy could predict the quality of life in patients with heart failure. So, it is crucial to consider health literacy in health promotion programs and improve the quality of life of these patients.
背景与目的:心衰症状及其并发症随着时间的推移会限制患者的正常生活过程,并可能影响患者的生活质量。因此,本研究旨在调查健康素养与在伊朗德黑兰市选定医院重症监护病房住院的心力衰竭患者的生活质量之间的关系。方法:选取105例心力衰竭患者作为研究对象。他们被送入德黑兰教育医院的心脏重症监护室。数据收集工具为人口统计信息、心力衰竭健康素养和生活质量问卷。采用SPSS v. 24进行描述性统计和相关回归统计。结果:心衰患者健康素养与生活质量评分呈显著正相关(r= 0.40)。此外,健康素养显著预测心力衰竭患者的生活质量评分(P<0.001)。双变量回归分析结果显示,健康素养评分能显著预测心衰患者的生活质量(P<0.001, r2= 0.16)。结论:健康素养可以预测心衰患者的生活质量。因此,在健康促进计划中考虑健康素养,提高这些患者的生活质量是至关重要的。
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引用次数: 0
The Effect of Health Promotion Support Program on Quality of Life in Patients With Type 2 Diabetes 健康促进支持计划对2型糖尿病患者生活质量的影响
Pub Date : 2021-07-01 DOI: 10.32598/qums.15.4.296
Fatemeh Zanjani, Sima Mohammad Khan kermanshahi, M. Gholami Fesharaki
Background and Objectives: Diabetics need to improve their lifestyle. They should control and prevent the complications of diabetes to improve their quality of life. This study aimed to investigate the effect of health promotion support programs on the quality of life in patients with type 2 diabetes. Methods: The present study was a quasi-clinical trial. A total of 60 people were selected by convenience sampling method and then divided purposefully into intervention (n= 30) and control (n= 30) groups. The health promotion support program was implemented in three stages: review and recognition, support planning, and evaluation. The study data were collected by Demographic and Quality of Life Questionnaire of diabetic patients (DQOL-BCI) before and two months after the intervention in the experimental and control groups. Results: The difference between the two groups regarding gender, age, marriage, education, and the job was not significant. The Mean±SD score of quality of life in the intervention group before the intervention was 46.8±8.06 and increased after the intervention to 56.8±6.06 (P <0.001). The Mean±SD score of quality of life in the control group before the intervention was 46.9±6.7 and increased after the intervention to 49.7±5.6, and this difference was statistically significant (P<0.001). The increase in the quality of life score of the intervention group was 10 units, but it was 2.87 units in the control group. Before the intervention, the difference in the quality of life scores of the two groups was not significant (the independent t-test, P=0.98), but after the intervention, this difference was significant (the independent t-test, P<0.001). Conclusion: The results showed that implementing a health promotion support program effectively improved the quality of life of type 2 diabetic patients. Therefore, it is suggested to be used as an effective method in improving the quality of life of diabetic patients and other chronic diseases.
背景和目的:糖尿病患者需要改善他们的生活方式。他们应该控制和预防糖尿病并发症,以提高他们的生活质量。本研究旨在探讨健康促进支持计划对2型糖尿病患者生活质量的影响。方法:本研究为准临床试验。采用方便抽样法抽取60人,有目的地分为干预组(n= 30)和对照组(n= 30)。健康促进支助方案分三个阶段实施:审查和确认、支助计划和评价。采用糖尿病患者人口统计与生活质量问卷(DQOL-BCI)对实验组和对照组患者进行干预前和干预后2个月的数据采集。结果:两组在性别、年龄、婚姻、学历、工作等方面差异不显著。干预组生活质量的均数±SD评分干预前为46.8±8.06,干预后为56.8±6.06 (P <0.001)。对照组患者干预前生活质量均值±SD评分为46.9±6.7分,干预后提高至49.7±5.6分,差异有统计学意义(P<0.001)。干预组生活质量评分提高10个单位,对照组提高2.87个单位。干预前两组患者的生活质量评分差异无统计学意义(独立t检验,P=0.98),干预后两组患者的生活质量评分差异有统计学意义(独立t检验,P<0.001)。结论:实施健康促进支持计划可有效改善2型糖尿病患者的生活质量。因此,建议将其作为改善糖尿病及其他慢性疾病患者生活质量的有效方法。
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引用次数: 0
Determining the Components of a Health Information Social Network Based on a Delphi Study 基于德尔菲研究确定健康信息社会网络的组成部分
Pub Date : 2021-07-01 DOI: 10.32598/qums.15.4.240
Akbar Mohammadi Motlaq, Z. Abazari, F. Sepehr
Background and Objectives: In recent years, social networks have been considered by organizations active in the health sector. They have provided many opportunities for consulting, training, and information sharing and held promises to increase the quality and safety of health care and reduce costs. So it is necessary to study their dimensions and requirements. This study aims to identify the components of the health information social network from the perspective of experts. Methods: This research is an analytical survey using the Delphi method. The statistical population included 28 experts in the field of health information technology in Iran. The data collection tool was a questionnaire whose validity was confirmed by experts, and its reliability was 0.96 according to the Cronbach α coefficient. SPSS software version 19 was used for data analysis. Results: According to this research, the health information social network has 6 dimensions, each has several components (a total of 47 components). These dimensions include services, core users, requirements, information security, evaluation and monitoring, and technical features. Conclusion: The dimensions of this network are based on the collective opinion of experts and are a framework for creating a social network of health information. Its use helps in planning and decision making and providing high-quality health services and leads to quality improvement of health indicators.
背景和目标:近年来,活跃在卫生部门的组织一直在考虑社会网络。它们为咨询、培训和信息共享提供了许多机会,并承诺提高医疗保健的质量和安全性,并降低成本。因此,有必要对其规模和要求进行研究。本研究旨在从专家的角度,找出健康资讯社会网路的组成要素。方法:采用德尔菲法进行分析性调查。统计人口包括伊朗保健信息技术领域的28名专家。数据收集工具为问卷,经专家确认效度,根据Cronbach α系数,信度为0.96。采用SPSS 19版软件进行数据分析。结果:根据本研究,健康信息社交网络有6个维度,每个维度有几个组成部分(共47个组成部分)。这些维度包括服务、核心用户、需求、信息安全、评估和监控以及技术特性。结论:该网络的维度基于专家的集体意见,是创建健康信息社会网络的框架。它的使用有助于规划和决策以及提供高质量的保健服务,并导致保健指标的质量提高。
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引用次数: 0
Designing and Validating an Instrument for Measuring the Effectiveness of Education in Medical Universities 医学院校教学效果测量工具的设计与验证
Pub Date : 2021-07-01 DOI: 10.32598/qums.15.4.272
Ali Reza Shouri Bidgolili, Gholamreza Vaisi, Gholamreza Sharifi Rad
Background and Objectives: The objectives of educational systems are missions, ideals, general goals, and behavior. Evaluation and judgment are essential for the training courses. Determining the effectiveness of the courses makes it possible to improve them. Numerous models evaluate training effectiveness, success, performance improvement, and desirability of training programs. Educational planners have always considered medical education and training of an efficient workforce. Because of the importance of education and the need for its continuous effectiveness in medical universities, we designed a tool to measure the effectiveness of medical education. Methods: The study method is a mixed qualitative-quantitative approach. The qualitative part of the content analysis was prepared to design and validate a tool with the statistical community of faculty members using qualitative and quantitative purposeful sampling. In the qualitative phase, 30 people were interviewed using semi-structured interviews. The components found were classified based on research methodology in 4 areas of course curriculum development, training course implementation, educational outcome and performance, and other accompanying factors. Then an effective measurement tool with good validity and reliability was designed. Regarding the face validity of the questionnaire, it was distributed among ten experts. To assess the reliability of the research tool, a questionnaire was distributed among 490 faculty members. Results: The results of measuring the reliability of the instrument by the Cronbach α values in the four domains were as follows: 0.875 in the area of curriculum development, 0.885 in the area of curriculum implementation, 0.890 in the curriculum outcome and performance, and 0.925 in other areas of the effective factors. These figures confirmed the validity of the tool. Also, using the agreement coefficient-test, the responses of faculty members and physicians and all stakeholders of medical universities showed more than 69% agreement. Conclusion: The study's findings showed that all the found components impact the effectiveness of education, and our designed tool was confirmed with appropriate and reliable validity and reliability.
背景和目标:教育系统的目标是使命、理想、总体目标和行为。评估和判断是培训课程必不可少的环节。确定课程的有效性,就有可能改进课程。许多模型评估培训的有效性、成功、绩效改进和培训计划的可取性。教育计划者一直在考虑医学教育和高效劳动力的培训。鉴于医学教育的重要性和医学教育持续有效性的需要,我们设计了一个衡量医学教育有效性的工具。方法:采用定性与定量相结合的研究方法。内容分析的定性部分准备设计和验证一个工具与统计社区的教员使用定性和定量有目的的抽样。在定性阶段,使用半结构化访谈对30人进行了访谈。所发现的组成部分根据研究方法在课程开发、培训课程实施、教育成果和表现以及其他伴随因素四个领域进行分类。然后设计了一种有效的测量工具,具有良好的效度和信度。对于问卷的面效度,将问卷分配给10位专家。为了评估研究工具的可靠性,在490名教员中分发了一份问卷。结果:四个领域的Cronbach α值测量工具的信度结果如下:课程开发领域为0.875,课程实施领域为0.885,课程成果和绩效领域为0.890,其他有效因素领域为0.925。这些数字证实了这个工具的有效性。此外,使用协议系数检验,教师和医生以及所有医科大学的利益相关者的反应显示超过69%的同意。结论:本研究结果显示,各成分均影响教学效果,所设计的工具具有适当的效度和信度。
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引用次数: 1
A Case Report of Neonatal Pemphigus Vulgaris 新生儿寻常型天疱疮1例报告
Pub Date : 2021-07-01 DOI: 10.32598/qums.15.4.306
M. Alipour, K. Khashei Varnamkhasti, Marzieh Eslami Moghaddam
Background and Objectives: Pemphigus vulgaris (PV) is a chronic, rare mucocutaneous autoimmune bullous disease characterized by flaccid blisters and or pustules, with secondary erosions of the mucous membranes or skin. PV threatens the patient life by forming splits within the epidermis, accompanied by acantholysis (separating keratinocytes from each other). Case Presentation: Our case is a term female neonate with PV, born of a 31-year-old mother. On initial examination by a pediatrician, several thin-walled flaccid blisters and burst blisters accompanied with open sores were observed on the skin of hands, feet, face, and mucosa of the oral cavity, tongue, and throat. A positive Nikolsky's sign confirmed her involvement with the disease.
背景和目的:寻常型天疱疮(Pemphigus vulgaris, PV)是一种慢性、罕见的粘膜皮肤自身免疫性大疱性疾病,其特征为弛缓性水疱和/或脓疱,继发性粘膜或皮肤糜烂。PV通过在表皮内形成分裂,并伴有棘层溶解(角质形成细胞相互分离),威胁到患者的生命。病例介绍:我们的病例是一名31岁的母亲所生的足月女性新生儿PV。在儿科医生的初步检查中,在手、脚、面部皮肤和口腔、舌头和喉咙粘膜上观察到一些薄壁松弛性水泡和爆裂性水泡,并伴有开放性溃疡。阳性的尼古斯基征证实了她与疾病有关。
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引用次数: 0
Evaluation of Sperm and Morphometric Parameters of Testicular Tissue Following Curcumin Administration in Rats After Varicocele Induction 姜黄素对大鼠精索静脉曲张诱导后精子及睾丸组织形态参数的影响
Pub Date : 2021-07-01 DOI: 10.32598/qums.15.4.284
Mohammadreza Sadraie, M. Tavalaee, M. Nasr-Esfahani, M. Forouzanfar
Background and Objectives: Varicocele is the abnormal dilation and twisting of the veins of the pampiniform network, the spermatic cord of the testis. This event is associated with increased oxidative stress and decreased antioxidant capacity. The consequence of varicocele is a reduction in the quality of sperm parameters and defects in spermatogenesis. Curcumin has been introduced as an antioxidant with multiple and modulating potentials in biological activities. This study investigates the effect of curcumin on sperm parameters and the histological status of testicular tissue in rats with varicocele. Methods: For this study, 50 male Wistar rats were examined in 5 different groups: control, sham, varicocele, varicocele treated with curcumin 50 mg/kg, and varicocele treated with curcumin 100 mg/kg. Varicocele was induced through partial occlusion of the left renal vein. Then, sperm parameters and histological status of testicular tissue were assessed and analyzed using ANOVA test after 2 months of curcumin administration in varicocele rats. Results: This study showed that varicocele led to a significant decrease in motility percentage (P= 0.007), sperm concentration (P= 0.036), and a significant increase in abnormal sperm morphology (P≥0.05) compared to the control group. Although administration of curcumin in varicocele rats with concentrations of 50 and 100 mg/kg led to an improvement in sperm parameters, only in varicocele rats received 100 mg/kg curcumin, the concentration (P= 0.032) and total sperm motility (P= 0.04) significantly improved compared to varicocele group. In addition, curcumin improved the tissue damage caused by varicocele and increased the spermatogenesis index. Conclusion: The present study showed that curcumin improves the low quality of sperm parameters and can be a treatment strategy for future male infertility.
背景和目的:精索静脉曲张是睾丸精索旁系网静脉的异常扩张和扭曲。这一事件与氧化应激增加和抗氧化能力下降有关。精索静脉曲张的后果是精子质量的下降和精子发生的缺陷。姜黄素是一种具有多种生物活性的抗氧化剂。本研究探讨姜黄素对精索静脉曲张大鼠精子参数及睾丸组织组织学状态的影响。方法:将50只雄性Wistar大鼠分为对照组、假手术组、精索静脉曲张组、精索静脉曲张组(姜黄素50 mg/kg)和精索静脉曲张组(姜黄素100 mg/kg)。通过左肾静脉部分闭塞诱导精索静脉曲张。采用方差分析方法对精索静脉曲张大鼠姜黄素给药2个月后的精子参数和睾丸组织组织学状态进行评价和分析。结果:本研究显示精索静脉曲张组与对照组相比,运动率(P= 0.007)显著降低,精子浓度(P= 0.036)显著降低,精子形态异常显著增加(P≥0.05)。虽然在精索静脉曲张大鼠中给药浓度为50和100 mg/kg的姜黄素可以改善精子参数,但与精索静脉曲张组相比,只有在精索静脉曲张大鼠中给药浓度为100 mg/kg的姜黄素显著改善了精子浓度(P= 0.032)和总精子活力(P= 0.04)。此外,姜黄素还能改善精索静脉曲张引起的组织损伤,提高精子发生指数。结论:本研究表明姜黄素可改善低质量精子参数,可作为未来男性不育症的治疗策略。
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引用次数: 1
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Qom Univ Med Sci J
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