Pub Date : 2021-09-01DOI: 10.32598/qums.15.6.2333.1
Elahe Zallaghi, G. Goudarzi, S. Sabzalipour, A. Zarasvandi
Background and Objectives: The main topic of this study was to impact assessment of the outcome of Acute Lower Respiratory Infection (ALRI) attributed to PM2.5 exposure using the AirQ+ model in Ahvaz, southwestern Iran, as one of the most polluted cities in the world during the period (2008-2017). Methods: Mortality data (including population and incidence of health outcome) and PM2.5 were obtained from the Deputy Minister of Health, Environmental Protection, and Meteorological Organizations of Ahvaz. After validating the data according to WHO guidelines, they entered the AirQ+ software. Also, BI values in 100 thousand people and RR with 95% confidence intervals were used. Results: The highest concentration of PM2.5 was in 2010 (70.72 µg/m3) and the lowest in 2014 (41.97 µg/m3) and in all years of measurement the amount of PM2.5 was higher than the WHO standard (10 µg/m3) was. The results showed that in the health outcome of ALRI, there was a significant relationship between PM2.5 concentration, ratio, and attributed cases. Thus, with the increase of air pollution in Ahvaz due to PM2.5 pollutants, mortality and risk of this disease increased. During the ten years under study, the highest proportions and attributed cases of AP, BE, and NE in all health outcomes were observed in 2010. In ALRI, 41.43% were 8 and 10 people. Conclusion: It can be concluded that appropriate measures and policies should be adopted to reduce air pollution in the control of PM2.5 pollutant sources. Until it reduced the health effects of this pollutant in urban children under 5 years of age.
{"title":"The Effect of PM2.5 pollutant on Acute Lower Respiratory Infection (ALRI) in Children Under 5 Years of Age in Ahvaz During the Years (2008-2017)","authors":"Elahe Zallaghi, G. Goudarzi, S. Sabzalipour, A. Zarasvandi","doi":"10.32598/qums.15.6.2333.1","DOIUrl":"https://doi.org/10.32598/qums.15.6.2333.1","url":null,"abstract":"Background and Objectives: The main topic of this study was to impact assessment of the outcome of Acute Lower Respiratory Infection (ALRI) attributed to PM2.5 exposure using the AirQ+ model in Ahvaz, southwestern Iran, as one of the most polluted cities in the world during the period (2008-2017). Methods: Mortality data (including population and incidence of health outcome) and PM2.5 were obtained from the Deputy Minister of Health, Environmental Protection, and Meteorological Organizations of Ahvaz. After validating the data according to WHO guidelines, they entered the AirQ+ software. Also, BI values in 100 thousand people and RR with 95% confidence intervals were used. Results: The highest concentration of PM2.5 was in 2010 (70.72 µg/m3) and the lowest in 2014 (41.97 µg/m3) and in all years of measurement the amount of PM2.5 was higher than the WHO standard (10 µg/m3) was. The results showed that in the health outcome of ALRI, there was a significant relationship between PM2.5 concentration, ratio, and attributed cases. Thus, with the increase of air pollution in Ahvaz due to PM2.5 pollutants, mortality and risk of this disease increased. During the ten years under study, the highest proportions and attributed cases of AP, BE, and NE in all health outcomes were observed in 2010. In ALRI, 41.43% were 8 and 10 people. Conclusion: It can be concluded that appropriate measures and policies should be adopted to reduce air pollution in the control of PM2.5 pollutant sources. Until it reduced the health effects of this pollutant in urban children under 5 years of age.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80904971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-01DOI: 10.32598/qums.15.6.2353.1
Fahimeh Zamani-Garmsiri, M. Najafi, Asghar Mohammadi, Farhad Shaikhnia, G. Ghasempour
Background and Objectives: Today, PEI is used for high-efficiency gene transfection. This polycation can have toxic effects on cells due to charged amine groups. This study evaluated the toxic effects of PEI in both single and oligonucleotide-binding modes on VSMC cells. Methods: First, VSMC cells were cultured and then transfected by nanoparticles in two PEI states alone and containing oligonucleotides. After 24 hours, cell viability and morphology were assessed using MTT and electron microscopy methods respectively. Data were analysed using the one-way ANOVA, followed by the Tukey Post-Hoc test. Results: The results showed that nanoparticles significantly reduced the cell viability by causing toxicity to cells (P<0.0001) and also its images showed cell death and apoptosis. But PEI containing oligonucleotides had no toxic effects on cell viability (P= 0.7414). Its electron microscope image also showed a normal cell morphology. Conclusion: Overall, this study showed that the effect of PEI toxicity on VSMC cells is inhibited by oligonucleotide sequencing and thus neutralizing the positive charges of the amine group.
{"title":"Evaluation of the Toxicity Effects of Polyethyleneimine (Pei) on Cell Viability and Morphology of VSMC Cells","authors":"Fahimeh Zamani-Garmsiri, M. Najafi, Asghar Mohammadi, Farhad Shaikhnia, G. Ghasempour","doi":"10.32598/qums.15.6.2353.1","DOIUrl":"https://doi.org/10.32598/qums.15.6.2353.1","url":null,"abstract":"Background and Objectives: Today, PEI is used for high-efficiency gene transfection. This polycation can have toxic effects on cells due to charged amine groups. This study evaluated the toxic effects of PEI in both single and oligonucleotide-binding modes on VSMC cells. Methods: First, VSMC cells were cultured and then transfected by nanoparticles in two PEI states alone and containing oligonucleotides. After 24 hours, cell viability and morphology were assessed using MTT and electron microscopy methods respectively. Data were analysed using the one-way ANOVA, followed by the Tukey Post-Hoc test. Results: The results showed that nanoparticles significantly reduced the cell viability by causing toxicity to cells (P<0.0001) and also its images showed cell death and apoptosis. But PEI containing oligonucleotides had no toxic effects on cell viability (P= 0.7414). Its electron microscope image also showed a normal cell morphology. Conclusion: Overall, this study showed that the effect of PEI toxicity on VSMC cells is inhibited by oligonucleotide sequencing and thus neutralizing the positive charges of the amine group.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76161180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-01DOI: 10.32598/qums.15.6.1334.2
Tayebeh Gogheri, S. A. Samavi, S. Najarpourian
Background and Objectives: Depression is a disorder in which personality factors are one of the presumed causes. The purpose of this study was to test the fit of structural model of personality type D and depression mediated by cognitive distortions and family functioning in the citizens of Bandar Abbas. Methods: This study was a correlation of structural equation modeling. Its population consisted of citizens of Bandar Abbas, from which 239 people were selected by stratified sampling. Measurement tools were Beck Depression Inventory (BDI), Type D Personality Scale (TDPS), Interpersonal Cognitive Distortion Scale (ICDS) and Family Performance Scale (FPS). Data were analyzed using structural equation modeling. Results: The model of this study has an acceptable fit with the data and family functioning has a mediating role between type D and depression, but the two variables of cognitive distortion and family function were not associated with depression. The results also showed that type D has a direct and significant effect on depression, cognitive distortions and family functioning Conclusion: Personality factors, especially type D, play a role in depression. Personality type D can affect family performance and cognition.
{"title":"Structural Relationships Model of Type D Personality and Depression With the Mediation of Cognitive Distortions and Family Functioning in the Citizens of Bandar Abbas","authors":"Tayebeh Gogheri, S. A. Samavi, S. Najarpourian","doi":"10.32598/qums.15.6.1334.2","DOIUrl":"https://doi.org/10.32598/qums.15.6.1334.2","url":null,"abstract":"Background and Objectives: Depression is a disorder in which personality factors are one of the presumed causes. The purpose of this study was to test the fit of structural model of personality type D and depression mediated by cognitive distortions and family functioning in the citizens of Bandar Abbas. Methods: This study was a correlation of structural equation modeling. Its population consisted of citizens of Bandar Abbas, from which 239 people were selected by stratified sampling. Measurement tools were Beck Depression Inventory (BDI), Type D Personality Scale (TDPS), Interpersonal Cognitive Distortion Scale (ICDS) and Family Performance Scale (FPS). Data were analyzed using structural equation modeling. Results: The model of this study has an acceptable fit with the data and family functioning has a mediating role between type D and depression, but the two variables of cognitive distortion and family function were not associated with depression. The results also showed that type D has a direct and significant effect on depression, cognitive distortions and family functioning Conclusion: Personality factors, especially type D, play a role in depression. Personality type D can affect family performance and cognition.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82465334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-01DOI: 10.32598/qums.15.6.2402.1
Sima Borun, Mahboubeh Fooladcheng, Bahram Jokar, F. Yousefi
Background and Objectives: The study of interventions for improving decision making and ethical behavior are of interest to researcher. The aim of this study was to investigate the effect of tDCS on adolescents’ decision-making and moral behavior. Methods: The method of the present study is quasi-experimental with a pretest-posttest design with a control group. 32 female high school students in Tehran were randomly selected and randomly divided into two groups of 16 people. The instruments used included the Ethical Sensitivity, Ethical Decision Making, and Ethical Behavior. Brain stimulation was performed with the TDCS device and at the DLPFC point of the brain anodally and unilaterally in six sessions of 20 minutes, 24 hours apart, with a voltage of 2 mA. Then, post-test was performed on both groups. Data were analyzed using t-test. Results: The results showed that there was a significant difference between the tDCS group and the control group in the variables of ethical decision making and ethical behavior (P<0.0001). Due to the difference in means, the tDCS group performed better than the control group. Conclusion: In a general conclusion, it can be stated that a 6-session course of tDCS brain stimulation has a positive effect on the decision-making and moral behavior of ninth grade junior high school female students, so it is necessary to examine the effectiveness of this intervention with different groups and in various conditions. And in the case of confirming this finding, it should be considered in counseling and planning centers.
{"title":"The Effectiveness of Transcranial Direct Current Stimulation (tDCS) on Adolescents’ Moral Decision Making and Moral Behavior","authors":"Sima Borun, Mahboubeh Fooladcheng, Bahram Jokar, F. Yousefi","doi":"10.32598/qums.15.6.2402.1","DOIUrl":"https://doi.org/10.32598/qums.15.6.2402.1","url":null,"abstract":"Background and Objectives: The study of interventions for improving decision making and ethical behavior are of interest to researcher. The aim of this study was to investigate the effect of tDCS on adolescents’ decision-making and moral behavior. Methods: The method of the present study is quasi-experimental with a pretest-posttest design with a control group. 32 female high school students in Tehran were randomly selected and randomly divided into two groups of 16 people. The instruments used included the Ethical Sensitivity, Ethical Decision Making, and Ethical Behavior. Brain stimulation was performed with the TDCS device and at the DLPFC point of the brain anodally and unilaterally in six sessions of 20 minutes, 24 hours apart, with a voltage of 2 mA. Then, post-test was performed on both groups. Data were analyzed using t-test. Results: The results showed that there was a significant difference between the tDCS group and the control group in the variables of ethical decision making and ethical behavior (P<0.0001). Due to the difference in means, the tDCS group performed better than the control group. Conclusion: In a general conclusion, it can be stated that a 6-session course of tDCS brain stimulation has a positive effect on the decision-making and moral behavior of ninth grade junior high school female students, so it is necessary to examine the effectiveness of this intervention with different groups and in various conditions. And in the case of confirming this finding, it should be considered in counseling and planning centers.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83003229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-01DOI: 10.32598/qums.15.6.2087.2
N. Pasyar, S. Gholamzadeh
Background and Objectives Self-esteem is an important psychological factor affecting the health and quality of life of students. This study was an attempt to investigate the predictive role of self-esteem and field of study determinants of mental health status of undergraduate health-professional students in Shiraz University of Medical Sciences in Iran. Methods In this descriptive cross-sectional study, a represented sample of year 1-4 undergraduate students (N=184) were invited to participate in the study students (Nursing, Midwifery, Operating room and Emergency medical students). Psychological health was measured using a standard instrument GHQ-28. CSEI also was applied to measure the students’ self-esteem Results A bout 44% of the students had GHQ scores of 23 and above, indicating an increased likelihood of psychological distress. Depression had the lowest Mean±SD score (3.92±4.2), while social dysfunction had the highest Mean±SD score (8.06±3.9) among the subscales. There was a significantly negative correlation between GHQ score and students’ self-esteem (P= 0.000, r= -0.556). The students with higher self-esteem experienced lower level of psychological distress. According to the regression analysis, 30.9% of the variance in students’ mental health is predicted by self-esteem. Conclusion A high prevalence of emotional disturbance among health care practitioners is likely to compound the existing problems of health care provision and that counseling and other support services should be made available to them.
{"title":"The Role of Self-esteem and Field of Study in Predicting Mental Health of Undergraduate Health-professional Students","authors":"N. Pasyar, S. Gholamzadeh","doi":"10.32598/qums.15.6.2087.2","DOIUrl":"https://doi.org/10.32598/qums.15.6.2087.2","url":null,"abstract":"Background and Objectives Self-esteem is an important psychological factor affecting the health and quality of life of students. This study was an attempt to investigate the predictive role of self-esteem and field of study determinants of mental health status of undergraduate health-professional students in Shiraz University of Medical Sciences in Iran. Methods In this descriptive cross-sectional study, a represented sample of year 1-4 undergraduate students (N=184) were invited to participate in the study students (Nursing, Midwifery, Operating room and Emergency medical students). Psychological health was measured using a standard instrument GHQ-28. CSEI also was applied to measure the students’ self-esteem Results A bout 44% of the students had GHQ scores of 23 and above, indicating an increased likelihood of psychological distress. Depression had the lowest Mean±SD score (3.92±4.2), while social dysfunction had the highest Mean±SD score (8.06±3.9) among the subscales. There was a significantly negative correlation between GHQ score and students’ self-esteem (P= 0.000, r= -0.556). The students with higher self-esteem experienced lower level of psychological distress. According to the regression analysis, 30.9% of the variance in students’ mental health is predicted by self-esteem. Conclusion A high prevalence of emotional disturbance among health care practitioners is likely to compound the existing problems of health care provision and that counseling and other support services should be made available to them.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85469254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-01DOI: 10.32598/qums.15.6.2414.1
N. Baghcheghi, H. Koohestani
Background and Objectives: Patients’ beliefs about medicines can affect their adherence to the medicines. The aim of this study was to determine beliefs about medicines and medication adherence and its associated factors in patients with chronic diseases. Methods: In this cross-sectional descriptive study, 268 patients with chronic diseases in 2019-2020 were included by convenience sampling method. The beliefs about medicines questionnaire and the Medication Adherence Scale were used for data collection. Data were analyzed in SPSS version 20 using One-Way Analysis of Variance (ANOVA), independent t-test and Pearson correlation coefficient at the significance level of α = 0.05. Results: The Mean±SD score of beliefs about medicines in terms of harms of medicines was 2.53±0.71, in benefits of medicines was 4.27±0.49 and overdose of the medicines was 3.23±0.79.There was a relationship between all three dimensions of beliefs about medicines with medication adherence (P<0.05). There was a direct relationship between the use of herbal medicine and belief in the harms of medicines (P<0.05). In addition, there was a relationship between gender and education level with belief in the benefits of the medicines (P<0.05). Conclusion: Some chronic patients’ beliefs about the drug were not appropriate and they believed that the drugs were harmful and that the drugs were over-prescribed by doctors. Belief in the harms of the medicines, the benefits of the medicines, and the overdose of the medicines are associated with medication adherence in patients with chronic diseases. Patients should be encouraged to express their views on medications in order to improve patients’ beliefs about medication.
背景与目的:患者对药物的信念会影响其对药物的依从性。本研究的目的是确定慢性疾病患者对药物和药物依从性及其相关因素的信念。方法:采用横断面描述性研究，采用方便抽样方法纳入2019-2020年慢性疾病患者268例。采用药物信念问卷和药物依从性量表进行数据收集。数据采用SPSS version 20进行分析，采用单因素方差分析(ANOVA)、独立t检验和Pearson相关系数，显著性水平为α = 0.05。结果:患者对药物危害的信念均值±SD为2.53±0.71，对药物获益的信念均值±SD为4.27±0.49，对药物过量的信念均值±SD为3.23±0.79。药物信念的三个维度与药物依从性之间存在显著相关(P<0.05)。使用草药与相信药物的危害有直接关系(P<0.05)。性别、受教育程度与相信药物获益程度之间存在相关性(P<0.05)。结论:部分慢性患者对药物的认知不正确，认为药物有害，认为医生开了过量的药。对药物的危害、药物的益处以及药物过量的信念与慢性病患者的药物依从性有关。应鼓励患者表达对药物的看法，以改善患者对药物的信念。
{"title":"Beliefs About Medicines and its Relationship With Medication Adherence in Patients With Chronic Diseases","authors":"N. Baghcheghi, H. Koohestani","doi":"10.32598/qums.15.6.2414.1","DOIUrl":"https://doi.org/10.32598/qums.15.6.2414.1","url":null,"abstract":"Background and Objectives: Patients’ beliefs about medicines can affect their adherence to the medicines. The aim of this study was to determine beliefs about medicines and medication adherence and its associated factors in patients with chronic diseases. Methods: In this cross-sectional descriptive study, 268 patients with chronic diseases in 2019-2020 were included by convenience sampling method. The beliefs about medicines questionnaire and the Medication Adherence Scale were used for data collection. Data were analyzed in SPSS version 20 using One-Way Analysis of Variance (ANOVA), independent t-test and Pearson correlation coefficient at the significance level of α = 0.05. Results: The Mean±SD score of beliefs about medicines in terms of harms of medicines was 2.53±0.71, in benefits of medicines was 4.27±0.49 and overdose of the medicines was 3.23±0.79.There was a relationship between all three dimensions of beliefs about medicines with medication adherence (P<0.05). There was a direct relationship between the use of herbal medicine and belief in the harms of medicines (P<0.05). In addition, there was a relationship between gender and education level with belief in the benefits of the medicines (P<0.05). Conclusion: Some chronic patients’ beliefs about the drug were not appropriate and they believed that the drugs were harmful and that the drugs were over-prescribed by doctors. Belief in the harms of the medicines, the benefits of the medicines, and the overdose of the medicines are associated with medication adherence in patients with chronic diseases. Patients should be encouraged to express their views on medications in order to improve patients’ beliefs about medication.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83732221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-01DOI: 10.32598/qums.15.5.1961.2
S. Khazaei, M. Soleimani, Seyed Hossein Ahmadi Tafti, Z. Hojati
Background and Objectives Cardiovascular disease is one of the leading causes of death worldwide. Mesenchymal stem cells (MSCs) are one of the most common sources of cell-based therapies in heart regeneration. There are several approaches to differentiate MSCs into cardiac-like cells, such as genetic modification. In addition, using of 3D culture, such as hydrogels, increases the efficiency of differentiation. Methods In the present study, lentiviruses containing microRNA 1 (miR- 1) and myocardium (Myocd) were co-transducted to mouse adipose-derived MSCs. Three days after, transduced MSCs were transferred to a hydrogel containing chitosan and collagen. After 21 days, the differentiation of encapsulated cells was evaluated. In this regard, the expression of cardiac markers such as NK2 homeobox 5 (Nkx2-5), GATA binding protein 4 (Gata4) and troponin T type 2 (Tnnt2) at the level of gene and protein were investigated. Results The results of real-time quantitative polymerase chain reaction (qRT-PCR) and immunocytochemistry showed that co-induction of miR-1 and Myocd in MSCs followed by transfer to composite hydrogel increased the expression of cardiac markers. Conclusion The use of 3D culture such as chitosan/collagen hydrogel improves the differentiation of MSCs and subsequently obtains more mature cells for use in cell-based regenerative medicine
{"title":"Differentiation of Mesenchymal Stem Cells Into Cardiac-like Cells by Co-induction of Lentiviruses Containing Mir-1 and Myocd in Chitosan Collagen Hydrogel Scaffold","authors":"S. Khazaei, M. Soleimani, Seyed Hossein Ahmadi Tafti, Z. Hojati","doi":"10.32598/qums.15.5.1961.2","DOIUrl":"https://doi.org/10.32598/qums.15.5.1961.2","url":null,"abstract":"Background and Objectives Cardiovascular disease is one of the leading causes of death worldwide. Mesenchymal stem cells (MSCs) are one of the most common sources of cell-based therapies in heart regeneration. There are several approaches to differentiate MSCs into cardiac-like cells, such as genetic modification. In addition, using of 3D culture, such as hydrogels, increases the efficiency of differentiation. Methods In the present study, lentiviruses containing microRNA 1 (miR- 1) and myocardium (Myocd) were co-transducted to mouse adipose-derived MSCs. Three days after, transduced MSCs were transferred to a hydrogel containing chitosan and collagen. After 21 days, the differentiation of encapsulated cells was evaluated. In this regard, the expression of cardiac markers such as NK2 homeobox 5 (Nkx2-5), GATA binding protein 4 (Gata4) and troponin T type 2 (Tnnt2) at the level of gene and protein were investigated. Results The results of real-time quantitative polymerase chain reaction (qRT-PCR) and immunocytochemistry showed that co-induction of miR-1 and Myocd in MSCs followed by transfer to composite hydrogel increased the expression of cardiac markers. Conclusion The use of 3D culture such as chitosan/collagen hydrogel improves the differentiation of MSCs and subsequently obtains more mature cells for use in cell-based regenerative medicine","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76639197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-01DOI: 10.32598/qums.15.5.2153.1
Zahra Afzoon, A. Hamta, M. Tabibi, N. Sadeghi
Background and Objectives: A cording to the importance of the effect of maternal health on pregnancy on the parts of the child’s mood, The purpose of this research was to determine and compare the perceptual sensitivity of infants of mothers with gestational diabetes and healthy mothers. Methods: This descriptive and causal-comparative research consisted of 88 mothers with infants aged 3-12 months who referred to the vaccination wards of Qom community health centers. The mothers were divided into two groups with and without a history of gestational diabetes. The research instruments were the IBQ-R infant mood assessment questionnaire and the individual information questionnaire. The data were analyzed using descriptive statistics, Mann-Whitney, Chi-square and SPSS software. Results: There is difference between the average perceptual sensitivity of infants of mothers with gestational diabetes and healthy mothers (P<0.05). the level of perceptual sensitivity in infants in mothers with a history of gestational diabetes is significantly higher than in infants of healthy mothers (P=0.034). Conclusion: Maternal diabetes during pregnancy is correlated to the perceptual sensitivity of infants. Maternal anxiety about the infant’s health can be reduced by justifying the infant’s behaviors by informing mothers with gestational diabetes in the postpartum period.
{"title":"Comparison of Perceptual Sensitivity of Infants of Mothers With Gestational Diabetes Mellitus With Healthy Mothers in City of Qom","authors":"Zahra Afzoon, A. Hamta, M. Tabibi, N. Sadeghi","doi":"10.32598/qums.15.5.2153.1","DOIUrl":"https://doi.org/10.32598/qums.15.5.2153.1","url":null,"abstract":"Background and Objectives: A cording to the importance of the effect of maternal health on pregnancy on the parts of the child’s mood, The purpose of this research was to determine and compare the perceptual sensitivity of infants of mothers with gestational diabetes and healthy mothers. Methods: This descriptive and causal-comparative research consisted of 88 mothers with infants aged 3-12 months who referred to the vaccination wards of Qom community health centers. The mothers were divided into two groups with and without a history of gestational diabetes. The research instruments were the IBQ-R infant mood assessment questionnaire and the individual information questionnaire. The data were analyzed using descriptive statistics, Mann-Whitney, Chi-square and SPSS software. Results: There is difference between the average perceptual sensitivity of infants of mothers with gestational diabetes and healthy mothers (P<0.05). the level of perceptual sensitivity in infants in mothers with a history of gestational diabetes is significantly higher than in infants of healthy mothers (P=0.034). Conclusion: Maternal diabetes during pregnancy is correlated to the perceptual sensitivity of infants. Maternal anxiety about the infant’s health can be reduced by justifying the infant’s behaviors by informing mothers with gestational diabetes in the postpartum period.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80334190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-01DOI: 10.32598/qums.15.5.2069.3.1
A. Rastgarian, N. Kalani, Nafiseh Esmaealpour, Mehrdad Estakhr, Z. Ghotbi, M. Jalali
Background and Objectives: Patients with multiple sclerosis, especially those treated with immunosuppressive drugs, are less immune than normal individuals and may be more susceptible to Covid 19. The aim of this study was to determine the level of knowledge of patients with MS of Covid 19 during the corona epidemic in Jahrom in 2021. Methods: This descriptive cross-sectional census study was performed on 191 patients with definite multiple sclerosis in Jahrom in 2021. Data collection tools included a demographic information questionnaire and a standard questionnaire for MS patients’ knowledge of Covid 19. Questionnaire information was collected in SPSS software version 21 and collected using descriptive and inferential statistical indicators. Results: Of 191 patients with MS during coron pandemic, 6.3% of them had coronary artery disease. The mean score of MS patients was (80.7%). There was a significant relationship between demographic variables such as gender, education and number of households with patients’ knowledge (P<0.05). The highest level of awareness was observed in men, patients with postgraduate education and patients with a large number of two-person households and in government employees with excellent economic status. The majority of patients considered the disease phase to be pandemic and the corona to be rapidly transmitted from person to person and its symptoms to be persistent fever and cough. The majority of patients also believed in the protective role of gloves and masks and the use of shields in preventing coronary heart disease. Conclusion: Patients with MS have a good understanding of this stage of the Covid 19 pandemic, while about 10% of them do not follow the quarantine rules completely. Therefore, training programs can be considered for these people who are at higher risk for Covid 19 infection.
{"title":"Awareness of Patients With MS From Covid 19: A Cross-sectional Descriptive Study on the Second Wave of Coronavirus in Jahrom City","authors":"A. Rastgarian, N. Kalani, Nafiseh Esmaealpour, Mehrdad Estakhr, Z. Ghotbi, M. Jalali","doi":"10.32598/qums.15.5.2069.3.1","DOIUrl":"https://doi.org/10.32598/qums.15.5.2069.3.1","url":null,"abstract":"Background and Objectives: Patients with multiple sclerosis, especially those treated with immunosuppressive drugs, are less immune than normal individuals and may be more susceptible to Covid 19. The aim of this study was to determine the level of knowledge of patients with MS of Covid 19 during the corona epidemic in Jahrom in 2021. Methods: This descriptive cross-sectional census study was performed on 191 patients with definite multiple sclerosis in Jahrom in 2021. Data collection tools included a demographic information questionnaire and a standard questionnaire for MS patients’ knowledge of Covid 19. Questionnaire information was collected in SPSS software version 21 and collected using descriptive and inferential statistical indicators. Results: Of 191 patients with MS during coron pandemic, 6.3% of them had coronary artery disease. The mean score of MS patients was (80.7%). There was a significant relationship between demographic variables such as gender, education and number of households with patients’ knowledge (P<0.05). The highest level of awareness was observed in men, patients with postgraduate education and patients with a large number of two-person households and in government employees with excellent economic status. The majority of patients considered the disease phase to be pandemic and the corona to be rapidly transmitted from person to person and its symptoms to be persistent fever and cough. The majority of patients also believed in the protective role of gloves and masks and the use of shields in preventing coronary heart disease. Conclusion: Patients with MS have a good understanding of this stage of the Covid 19 pandemic, while about 10% of them do not follow the quarantine rules completely. Therefore, training programs can be considered for these people who are at higher risk for Covid 19 infection.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73790886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and Objectives: Inter-professional collaboration is one of the most important components of patient safety.Understanding the components of interprofessional collaboration is essential. So far, few studies have been conducted on interprofessional cooperation in the operating room, worldwide and in Iran.The aim of this study was to explain the experiences of operating room staff from the components and examples of interprofessional collaboration using the phenomenological approach by Colaizzi method (1978). The aim of this study was to explain the experiences of operating room staff from the components and examples of interprofessional collaboration using the phenomenological approach by Colaizzi method (1978). The aim of this study was to explain the experiences of operating room staff from the components and examples of interprofessional collaboration using the phenomenological approach Colaizzi method (1978). Methods: 12 employees working in different professions in the operating room of Qom hospitals were included.The study was conducted in a qualitative phenomenological manner with the Colaizzi method and structured goal-based interviews. Results: From the analysis of the obtained data, 6 Emergent Them and 20 Theme Clusters were obtained as follows: “Organization” (goal setting and shared resources), “Professional Identity” (commitment,mutualrespect, synergy and clear role), ”Communication” (Collaboration, Trust, Information Sharing, and Conflict Management “Team Characteristics (Flexibility, Experience, Participation, Teamwork, and responsibility،accountability)”, Leadership and Management (Operating Room Leadership, Hierarchy Structure, Climate, Working Conditions, and Capacity) “Coordination” (planning) Conclusion: Staff training and explaining the experience of other operating room staff about the components of Inter-professional collaboration, could be considered as one of the main steps to achieve inter- Inter-professional collaboration and patient safety. The results of this study can be helpful education officials in improving and improving the quality of joint inter-professional training programs.
{"title":"Exploration of the Operating Room Personnel From Components and Examples of Interprofessional Collaboration: A Phenomenological Study","authors":"M. Amini, Hoda Ahmari Tehran, S. Ahmadi","doi":"10.32598/qums.15.5.2248","DOIUrl":"https://doi.org/10.32598/qums.15.5.2248","url":null,"abstract":"Background and Objectives: Inter-professional collaboration is one of the most important components of patient safety.Understanding the components of interprofessional collaboration is essential. So far, few studies have been conducted on interprofessional cooperation in the operating room, worldwide and in Iran.The aim of this study was to explain the experiences of operating room staff from the components and examples of interprofessional collaboration using the phenomenological approach by Colaizzi method (1978). The aim of this study was to explain the experiences of operating room staff from the components and examples of interprofessional collaboration using the phenomenological approach by Colaizzi method (1978). The aim of this study was to explain the experiences of operating room staff from the components and examples of interprofessional collaboration using the phenomenological approach Colaizzi method (1978). Methods: 12 employees working in different professions in the operating room of Qom hospitals were included.The study was conducted in a qualitative phenomenological manner with the Colaizzi method and structured goal-based interviews. Results: From the analysis of the obtained data, 6 Emergent Them and 20 Theme Clusters were obtained as follows: “Organization” (goal setting and shared resources), “Professional Identity” (commitment,mutualrespect, synergy and clear role), ”Communication” (Collaboration, Trust, Information Sharing, and Conflict Management “Team Characteristics (Flexibility, Experience, Participation, Teamwork, and responsibility،accountability)”, Leadership and Management (Operating Room Leadership, Hierarchy Structure, Climate, Working Conditions, and Capacity) “Coordination” (planning) Conclusion: Staff training and explaining the experience of other operating room staff about the components of Inter-professional collaboration, could be considered as one of the main steps to achieve inter- Inter-professional collaboration and patient safety. The results of this study can be helpful education officials in improving and improving the quality of joint inter-professional training programs.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90617098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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