Pub Date : 2022-01-01DOI: 10.32598/qums.15.10.2346.1
M. Mashhadi, M. Sahebozamani, A. Daneshjoo, S. Adeli, Nahid Venarji
Background and Objectives: Coronavirus disease 2019 (Covid-19) Acute Respiratory Syndrome has spread around the world. Various persistent complications and symptoms, including various physical and mental disorders, have been observed in recovered and discharged patients. The purpose of this review article was to study the persistent symptoms in patients recovering from Covid-19 and the importance of rehabilitation in the post-acute phase. Methods: In this review study, related articles from databases including Google Scholar, PubMed, Medline, ScienceDirect, SID, Inlm, Web of Science, Scopus, Springer from 2019 to August 2021, were reviewed. The following keywords were also used in the article search process: Covid-19 (and similar) recovered, survivors, discharged, Persistent symptoms, consequences and post-acute. Results: A search of articles in databases identified 10,227 articles. After removing duplicate articles, articles in non-Persian and English languages, non-research articles and non- related articles, 61 articles were obtained that examined the persistent symptoms of recovered and discharged patients. The most persistent symptoms included dyspnea, fatigue and acquired weakness, psychological problems, and decreased quality of life. Conclusion: The results showed that due to the persistent symptoms and clinical condition of Covid-19 disease, motor and pulmonary rehabilitation is necessary for the recovering. These programs should be continued in specialized departments or through home rehabilitation with the aim of regaining motor skills and improving mental health.
背景与目的:冠状病毒病2019 (Covid-19)急性呼吸综合征已在全球蔓延。在康复和出院的病人中观察到各种持续的并发症和症状，包括各种身体和精神障碍。本综述的目的是研究Covid-19康复患者的持续症状以及急性期后康复的重要性。方法:回顾性分析2019年至2021年8月Google Scholar、PubMed、Medline、ScienceDirect、SID、Inlm、Web of Science、Scopus、Springer等数据库的相关文章。文章检索过程中还使用了以下关键词:Covid-19(及类似)康复、幸存者、出院、持续症状、后果和急性后。结果:在数据库中搜索了10227篇文章。在删除重复文章、非波斯语和英语的文章、非研究文章和非相关文章后，获得了61篇研究康复和出院患者持续症状的文章。最持久的症状包括呼吸困难、疲劳和获得性虚弱、心理问题和生活质量下降。结论:由于新型冠状病毒病的持续症状和临床状况，运动和肺部康复是康复的必要条件。这些计划应该在专门的部门或通过家庭康复继续进行，目的是恢复运动技能和改善心理健康。
{"title":"Persistent Symptoms in Recovered Patient From Covid-19 and the Importance of Post-acute Rehabilitation: A Systematic Review","authors":"M. Mashhadi, M. Sahebozamani, A. Daneshjoo, S. Adeli, Nahid Venarji","doi":"10.32598/qums.15.10.2346.1","DOIUrl":"https://doi.org/10.32598/qums.15.10.2346.1","url":null,"abstract":"Background and Objectives: Coronavirus disease 2019 (Covid-19) Acute Respiratory Syndrome has spread around the world. Various persistent complications and symptoms, including various physical and mental disorders, have been observed in recovered and discharged patients. The purpose of this review article was to study the persistent symptoms in patients recovering from Covid-19 and the importance of rehabilitation in the post-acute phase. Methods: In this review study, related articles from databases including Google Scholar, PubMed, Medline, ScienceDirect, SID, Inlm, Web of Science, Scopus, Springer from 2019 to August 2021, were reviewed. The following keywords were also used in the article search process: Covid-19 (and similar) recovered, survivors, discharged, Persistent symptoms, consequences and post-acute. Results: A search of articles in databases identified 10,227 articles. After removing duplicate articles, articles in non-Persian and English languages, non-research articles and non- related articles, 61 articles were obtained that examined the persistent symptoms of recovered and discharged patients. The most persistent symptoms included dyspnea, fatigue and acquired weakness, psychological problems, and decreased quality of life. Conclusion: The results showed that due to the persistent symptoms and clinical condition of Covid-19 disease, motor and pulmonary rehabilitation is necessary for the recovering. These programs should be continued in specialized departments or through home rehabilitation with the aim of regaining motor skills and improving mental health.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90716763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32598/qums.15.10.2522.1
O. Davarinejad, Tahereh Mohammadi Majd, M. Abbasi, S. Eskandari
Background and Objectives: Schizophrenia is one of the most severe psychiatric disorders that has a recurrent nature. Frequent relapses have destructive impacts on patient’s thoughts, behaviors and relationships. These can lead to disruption of personal and social performance of patient. The aim of this study was to identify risk factors for increasing the number of relapses. Methods: In this retrospective cohort study, data from medical records of individuals with SSD who were admitted at least once to Farabi Hospital between 2015 and 2019 years extracted. To determine factors related to recurrence of Schizophrenia, Univariate and multivariate analysis and multivariate Poisson Regression were performed respectively. Analysis was done using STATA 14.1. Results: Based on extracted data from 401 medical records, 255 (63.6%) were males and 146 (36.4%) were females. A total of 1105 relapse were observed in males with 683 cases, and females with 422 cases. 65 patient experienced relapse from 5 to 11 times. Among considered variables, Employment status (RR=0.85, P-value=0.043), age (RR=0.99, P-value=0.03), Mode of Onset (RR=0.78, P-value=0.027) and Medication Adherence (RR=1.67, P<0.001) were significant on increasing readmission. Conclusion: According to the results of this study, the young age of onset of schizophrenia, the gradual onset of the disorder, unemployment and drug non-compliance had a significant effect on increasing the risk of recurrence in patients with schizophrenia. considering above risk factors, it seems necessary to perform preventive and therapeutic measures to reduce the risk of relapses. Patients with non-adherence can be under education and counseling.
{"title":"Identification of Effective Factors in Recurrence of Schizophrenia Spectrum Disorder Using Poisson Regression Model","authors":"O. Davarinejad, Tahereh Mohammadi Majd, M. Abbasi, S. Eskandari","doi":"10.32598/qums.15.10.2522.1","DOIUrl":"https://doi.org/10.32598/qums.15.10.2522.1","url":null,"abstract":"Background and Objectives: Schizophrenia is one of the most severe psychiatric disorders that has a recurrent nature. Frequent relapses have destructive impacts on patient’s thoughts, behaviors and relationships. These can lead to disruption of personal and social performance of patient. The aim of this study was to identify risk factors for increasing the number of relapses. Methods: In this retrospective cohort study, data from medical records of individuals with SSD who were admitted at least once to Farabi Hospital between 2015 and 2019 years extracted. To determine factors related to recurrence of Schizophrenia, Univariate and multivariate analysis and multivariate Poisson Regression were performed respectively. Analysis was done using STATA 14.1. Results: Based on extracted data from 401 medical records, 255 (63.6%) were males and 146 (36.4%) were females. A total of 1105 relapse were observed in males with 683 cases, and females with 422 cases. 65 patient experienced relapse from 5 to 11 times. Among considered variables, Employment status (RR=0.85, P-value=0.043), age (RR=0.99, P-value=0.03), Mode of Onset (RR=0.78, P-value=0.027) and Medication Adherence (RR=1.67, P<0.001) were significant on increasing readmission. Conclusion: According to the results of this study, the young age of onset of schizophrenia, the gradual onset of the disorder, unemployment and drug non-compliance had a significant effect on increasing the risk of recurrence in patients with schizophrenia. considering above risk factors, it seems necessary to perform preventive and therapeutic measures to reduce the risk of relapses. Patients with non-adherence can be under education and counseling.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87924154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32598/qums.15.10.2441
Taghi Hajiloie, A. Zahirnia, H. Nasirian, B. Davari
Background and Objectives: Despite the progress of communities’ health, head lice (Pediculus capitis) infestation remains a major health problem. The aim of the study was to investigate the prevalence of head lice infestation and its associated factors among female primary school students in Ghahavand County and compare with the previous studies. Methods: The students were cross-sectionally examined and pediculosis infected students were identified. The student demographic information was collected and recorded. The results were analyzed by Chi-square test of SPSS software. Significance level was considered P<0.05. Results: Among 499 students participating in the study, 89 students (17.8%) had pediculosis. There was a significant difference between student pediculosis prevalence in terms of parents’ educational level, previous infestation history, parental assistance in health affairs, number of household members, and condition, type and length of students’ hair (P<0.05) But there was not a significant difference between student pediculosis prevalence in terms of student educational level, father’s employment, weekly bathing, and the use of personal brush (P>0.05). The results compared with the previous studies. Conclusion: Head lice infestation is relatively high in students that depends on factors such as parent educational levels, previous infestation history, parental assistance in health care, number of household members, and the condition, type and length of the students’ hair. It is recommended to treat the pediculosis infected students along with attention to the instructions and training of parents and school health instructors.
{"title":"Prevalence of Head Lice Infestation and its Associated Factors Among Female Primary School Students in Ghahavand County and Compared with the Previous Studies","authors":"Taghi Hajiloie, A. Zahirnia, H. Nasirian, B. Davari","doi":"10.32598/qums.15.10.2441","DOIUrl":"https://doi.org/10.32598/qums.15.10.2441","url":null,"abstract":"Background and Objectives: Despite the progress of communities’ health, head lice (Pediculus capitis) infestation remains a major health problem. The aim of the study was to investigate the prevalence of head lice infestation and its associated factors among female primary school students in Ghahavand County and compare with the previous studies. Methods: The students were cross-sectionally examined and pediculosis infected students were identified. The student demographic information was collected and recorded. The results were analyzed by Chi-square test of SPSS software. Significance level was considered P<0.05. Results: Among 499 students participating in the study, 89 students (17.8%) had pediculosis. There was a significant difference between student pediculosis prevalence in terms of parents’ educational level, previous infestation history, parental assistance in health affairs, number of household members, and condition, type and length of students’ hair (P<0.05) But there was not a significant difference between student pediculosis prevalence in terms of student educational level, father’s employment, weekly bathing, and the use of personal brush (P>0.05). The results compared with the previous studies. Conclusion: Head lice infestation is relatively high in students that depends on factors such as parent educational levels, previous infestation history, parental assistance in health care, number of household members, and the condition, type and length of the students’ hair. It is recommended to treat the pediculosis infected students along with attention to the instructions and training of parents and school health instructors.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90775774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32598/qums.15.10.2282.2
Ali Zarepour Moghadami, R. Norouzadeh
Background and Objectives: One of the factors affecting healthy behaviors in the elderly is self-efficacy and happiness will lead to success and health; therefore, the aim of this study was to determine the relationship between elderly happiness and self-efficacy in the elderly with chronic diseases. Methods: A descriptive-analytical study was conducted among 132 elderly people aged 60 years and older living in a nursing home in Tabriz, IRAN (2010) that the sampling method was accessible and easy. Data were collected using Demographic Information Questionnaire and Oxford Happiness Questionnaire, General Self-Efficacy Beliefs Scale and analyzed by SPSS v. 18 software Results: There was a significant relationship between happiness and marriage in the elderly (P=0.02) and between the self-efficacy score of the elderly with gender (P=0.02) and job (P=0.03) in order to have enough money to meet their needs (P=0.008). According to regression analysis, there was a statistical relationship between self-efficacy of the elderly with education and marriage (P=0.04). According to the positive correlation coefficient, with increasing Happiness, self-efficacy of the elderly also increases. Conclusion: Increasing the happiness of the elderly will improve their performance in better management of treatment through appropriate self-efficacy.
背景与目的:影响老年人健康行为的因素之一是自我效能感，快乐会导致成功和健康;因此，本研究的目的是确定老年幸福感与慢性疾病老年人自我效能感之间的关系。方法:对伊朗大不里士市(Tabriz, 2010)一家养老院的132名60岁及以上老年人进行描述性分析研究，抽样方法简便易行。采用人口统计信息问卷、牛津幸福问卷、一般自我效能信念量表收集数据，并采用SPSS v. 18软件进行分析。结果:老年人的幸福感与婚姻存在显著相关(P=0.02)，不同性别老年人的自我效能得分(P=0.02)与为了有足够的钱来满足自己的需要而工作(P=0.03)存在显著相关(P= 0.008)。经回归分析，老年人的自我效能感与受教育程度、婚姻关系有统计学意义(P=0.04)。从正相关系数来看，随着幸福感的增加，老年人的自我效能感也随之增加。结论:通过适当的自我效能感，提高老年人的幸福感，可以提高老年人在更好地管理治疗方面的表现。
{"title":"The Relationship between Elderly Happiness and Self-Efficacy in the Elderly with Chronic Disease Residing in a Nursing Home, Tabriz, 2020","authors":"Ali Zarepour Moghadami, R. Norouzadeh","doi":"10.32598/qums.15.10.2282.2","DOIUrl":"https://doi.org/10.32598/qums.15.10.2282.2","url":null,"abstract":"Background and Objectives: One of the factors affecting healthy behaviors in the elderly is self-efficacy and happiness will lead to success and health; therefore, the aim of this study was to determine the relationship between elderly happiness and self-efficacy in the elderly with chronic diseases. Methods: A descriptive-analytical study was conducted among 132 elderly people aged 60 years and older living in a nursing home in Tabriz, IRAN (2010) that the sampling method was accessible and easy. Data were collected using Demographic Information Questionnaire and Oxford Happiness Questionnaire, General Self-Efficacy Beliefs Scale and analyzed by SPSS v. 18 software Results: There was a significant relationship between happiness and marriage in the elderly (P=0.02) and between the self-efficacy score of the elderly with gender (P=0.02) and job (P=0.03) in order to have enough money to meet their needs (P=0.008). According to regression analysis, there was a statistical relationship between self-efficacy of the elderly with education and marriage (P=0.04). According to the positive correlation coefficient, with increasing Happiness, self-efficacy of the elderly also increases. Conclusion: Increasing the happiness of the elderly will improve their performance in better management of treatment through appropriate self-efficacy.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84351273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32598/qums.15.10.2503.1
Mohammad Sasanipour
Background and Objectives: In order to evaluate the burden of disease in the provinces of Iran, this study seeks to investigate the provincial differences of the main causes of years of life lost in old age in 2016. Methods: This is a descriptive cross-sectional study that was conducted in 2016 at the provincial and national levels. These data were obtained from the registration system of the Ministry of Health and Medical Education, and using the standard method of the World Health Organization, the number of years of life lost was calculated based on three causes of death for the elderly. Results: The share of elderly deaths in total deaths ranged from 43% in Sistan and Baluchestan province to 77% in Gilan province. Golestan province had the highest YLL rate due to cardiovascular diseases (345 per thousand) and cancers (227 per thousand) in old age and Kerman province with 81 per thousand had the highest YLL rate due to respiratory diseases at this age they had. Conclusion: Increasing the proportion of elderly population in the future and, consequently, the increasing trend of deaths at this age and in order to better manage it, it is necessary to pay attention to provincial differences and potentials to improve the health of the elderly, especially in the field of causes of death.
{"title":"Provincial Differences in the Main Causes of Years of Life Lost Due to Premature Death of Iranian Elderly in 2016","authors":"Mohammad Sasanipour","doi":"10.32598/qums.15.10.2503.1","DOIUrl":"https://doi.org/10.32598/qums.15.10.2503.1","url":null,"abstract":"Background and Objectives: In order to evaluate the burden of disease in the provinces of Iran, this study seeks to investigate the provincial differences of the main causes of years of life lost in old age in 2016. Methods: This is a descriptive cross-sectional study that was conducted in 2016 at the provincial and national levels. These data were obtained from the registration system of the Ministry of Health and Medical Education, and using the standard method of the World Health Organization, the number of years of life lost was calculated based on three causes of death for the elderly. Results: The share of elderly deaths in total deaths ranged from 43% in Sistan and Baluchestan province to 77% in Gilan province. Golestan province had the highest YLL rate due to cardiovascular diseases (345 per thousand) and cancers (227 per thousand) in old age and Kerman province with 81 per thousand had the highest YLL rate due to respiratory diseases at this age they had. Conclusion: Increasing the proportion of elderly population in the future and, consequently, the increasing trend of deaths at this age and in order to better manage it, it is necessary to pay attention to provincial differences and potentials to improve the health of the elderly, especially in the field of causes of death.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89136757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.32598/qums.15.9.2448.1
Bahman Ghasemzadeh, S. Shahsavari, Aisa Maleki, R. Kalhor
Background and Objectives: The present study was conducted to investigate the status of performance indicators in hospitals affiliated to Qazvin University of Medical Sciences before and after the implementation of the transformation plan. Methods: This descriptive-analytical study was performed longitudinally based on hospital data. The data collection tool was a checklist including general characteristics of hospitals and performance indicators. Data analysis was performed using Interrupted time series analysis (ITS) and Statistical software for data science (STATA) v.15. Chow test was used to determine the structural fractures in the studied time series. Results: Hospitals’ performance indicators were examined. In the first month after the intervention, bed rotation increased significantly by 1.148 (P<0.005). The trend of bed rotation after the intervention increased by 0.060 per month (P=0.032). In the first month after the intervention, the decrease or increase in the length of stay in different hospitals was not significant (P>0.005). The length of stay after the intervention increased by 0.170 per month. In the first month after the intervention, the decrease in bed occupancy percentage was 41% (P=0.005) which is significant. The trend of bed occupancy percentage after the intervention was more than 2% per month (P<0.005). Conclusion: The transformation plan in the period before and after implementation in all studied hospitals has positive effects and has made changes in most performance indicators. This plan is especially beneficial for people who have fallen ill due to a lack of financial resources and have not been able to seek treatment.
{"title":"Evaluation of Performance Indicators of Qazvin Educational and Medical Centers before and after the Implementation of the Health System Transformation Plan: Interrupted Time Series Analysis","authors":"Bahman Ghasemzadeh, S. Shahsavari, Aisa Maleki, R. Kalhor","doi":"10.32598/qums.15.9.2448.1","DOIUrl":"https://doi.org/10.32598/qums.15.9.2448.1","url":null,"abstract":"Background and Objectives: The present study was conducted to investigate the status of performance indicators in hospitals affiliated to Qazvin University of Medical Sciences before and after the implementation of the transformation plan. Methods: This descriptive-analytical study was performed longitudinally based on hospital data. The data collection tool was a checklist including general characteristics of hospitals and performance indicators. Data analysis was performed using Interrupted time series analysis (ITS) and Statistical software for data science (STATA) v.15. Chow test was used to determine the structural fractures in the studied time series. Results: Hospitals’ performance indicators were examined. In the first month after the intervention, bed rotation increased significantly by 1.148 (P<0.005). The trend of bed rotation after the intervention increased by 0.060 per month (P=0.032). In the first month after the intervention, the decrease or increase in the length of stay in different hospitals was not significant (P>0.005). The length of stay after the intervention increased by 0.170 per month. In the first month after the intervention, the decrease in bed occupancy percentage was 41% (P=0.005) which is significant. The trend of bed occupancy percentage after the intervention was more than 2% per month (P<0.005). Conclusion: The transformation plan in the period before and after implementation in all studied hospitals has positive effects and has made changes in most performance indicators. This plan is especially beneficial for people who have fallen ill due to a lack of financial resources and have not been able to seek treatment.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84354475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.32598/qums.15.9.2406.1
Sedigheh Sadat Borhani, N. Heidarieh, N. Hayati Roodbari, Kambiz Roshanaei
Background and Objectives: Levofloxacin is a fluoroquinolone. Long-term use of antibiotics, including fluoroquinolone antibiotics, causes dystrophic changes in the ovaries. In this study, the effects of levofloxacin on the development of ovarian follicles and their apoptosis in the in vitro and in vivo conditions of NMRI Mouse were investigated. Methods: In the vitro study, isolated ovaries of animals were treated with levofloxacin at concentrations of 1, 2, 5, 10 µg/ml for 6 days and in the vivo study were treated with levofloxacin at concentrations of 100, 200, 400 and 800 mg/kg. After 24 days, animals were sacrificed in the in vivo groups and ovary samples were obtained. Hematoxylin and eosin (H&E) stains for histological studies also Real Time PCR techniques for study of expression rate of Bax and Bcl-2 genes were performed in both groups. Results: The results of the in vitro study showed that the dose of 2 μg/ml induced apoptosis in the monolayer primary follicles. Doses of 5 and 10 μg/ml increased the induction of apoptosis in the multilayer primary follicle. The number of secondary follicles at the 5 μg/ml dose had the most decrease. While at the dose of 10 μg/ml, the number of mature follicles had the most increase. As the antibiotic concentration increases, the expression of the Bax gene decreases and Bcl-2 gene increases significantly. The results of the in vitro study showed that the number of primary and secondary follicles decreased dose-dependently. The number of atretic follicles increased significantly with increasing dose. The expression of the Bax and Bcl-2 genes increased with increasing levofloxacin antibiotic concentration. Conclusion: This study demonstrates that levofloxacin induces apoptosis in ovarian follicles
{"title":"Effects of Levofloxacin on Expression of Apoptosis Genes of Ovarian Follicles in NMRI Mouse in Vitro and in Vivo","authors":"Sedigheh Sadat Borhani, N. Heidarieh, N. Hayati Roodbari, Kambiz Roshanaei","doi":"10.32598/qums.15.9.2406.1","DOIUrl":"https://doi.org/10.32598/qums.15.9.2406.1","url":null,"abstract":"Background and Objectives: Levofloxacin is a fluoroquinolone. Long-term use of antibiotics, including fluoroquinolone antibiotics, causes dystrophic changes in the ovaries. In this study, the effects of levofloxacin on the development of ovarian follicles and their apoptosis in the in vitro and in vivo conditions of NMRI Mouse were investigated. Methods: In the vitro study, isolated ovaries of animals were treated with levofloxacin at concentrations of 1, 2, 5, 10 µg/ml for 6 days and in the vivo study were treated with levofloxacin at concentrations of 100, 200, 400 and 800 mg/kg. After 24 days, animals were sacrificed in the in vivo groups and ovary samples were obtained. Hematoxylin and eosin (H&E) stains for histological studies also Real Time PCR techniques for study of expression rate of Bax and Bcl-2 genes were performed in both groups. Results: The results of the in vitro study showed that the dose of 2 μg/ml induced apoptosis in the monolayer primary follicles. Doses of 5 and 10 μg/ml increased the induction of apoptosis in the multilayer primary follicle. The number of secondary follicles at the 5 μg/ml dose had the most decrease. While at the dose of 10 μg/ml, the number of mature follicles had the most increase. As the antibiotic concentration increases, the expression of the Bax gene decreases and Bcl-2 gene increases significantly. The results of the in vitro study showed that the number of primary and secondary follicles decreased dose-dependently. The number of atretic follicles increased significantly with increasing dose. The expression of the Bax and Bcl-2 genes increased with increasing levofloxacin antibiotic concentration. Conclusion: This study demonstrates that levofloxacin induces apoptosis in ovarian follicles","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80756267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.32598/qums.15.9.377.2
R. Norouzi, Abolghasem Siadatpanah, F. Mirzaei, Ruhollah Fateh, Mohammad Khalifeh Gholi, Seyyed Jafar Adnani Sadati
Background and Objectives: Cutaneous leishmaniasis is one of the common diseases between humans and animals that is considered a health problem in Iran and many countries around the world. Currently, glucantime is used to treat cutaneous leishmaniasis. Due to its high side effects and resistance, the use of alternative therapies, especially plants and natural compounds, has been highly recommended by researchers. The aim of this study is to investigate the effect of the methanolic extract of dandelion root (Taraxacum officinale) on Leishmania major in vitro techniques. Methods: In this experimental study, the extract was prepared by the Soxhlet method and to evaluate the effect of methanolic extract of dandelion root on L. major parasite at concentrations of 300-1200 mg/ml. Amphotericin B and distilled water were considered as positive and negative controls, respectively. Then, 106 live parasites were added to all tubes, and all groups were kept at 25 ±1 °C. At 24, 48, and 72 hours, the number of live parasites was counted by Trypan Blue using a neobar slide and light microscope (Hemocytometer method). Then Half-maximal inhibitory concentration (IC50) value for the above extract was calculated using SigmaPlot™ 13 software. All steps of the experiment were done in triplicate and the results were considered as average. Results: The IC50 content of methanolic extract of dandelion roots after 24, 48, and 72 hours on L. major were calculated to be 1.04, 0.9, and 0.68 µg/ml. The highest growth inhibition (100%) was observed at a concentration of 1200 μg/ml after 72 hours of exposure. There was a significant difference between the IC50 extract and amphotericin B drug after 24, 48 and 72 hours (P<0.05). Conclusion: Methanolic extract of dandelion root in different concentrations has an inhibitory effect on the growth of L. major and it is suggested that more and more complete studies be performed on the components of this plant and the lethal effect of the parasite in vivo.
背景和目的:皮肤利什曼病是人类和动物之间的常见疾病之一，在伊朗和世界许多国家被认为是一个健康问题。目前，葡聚糖被用于治疗皮肤利什曼病。由于其高副作用和耐药性，使用替代疗法，特别是植物和天然化合物，已被研究人员强烈推荐。本研究旨在探讨蒲公英根甲醇提取物对利什曼原虫的体外抑制作用。方法:采用索氏法制备蒲公英根甲醇提取物，评价蒲公英根甲醇提取物在300 ~ 1200mg /ml浓度下对L. major parasite的抑制作用。两性霉素B和蒸馏水分别作为阳性对照和阴性对照。然后，在所有试管中加入106只活寄生虫，各组均保存在25±1℃。在24、48和72小时，用新条形载玻片和光学显微镜(血细胞计法)对活寄生虫数量进行台盼蓝计数。然后使用SigmaPlot™13软件计算上述提取物的半最大抑制浓度(IC50)值。实验的所有步骤均为三次重复，结果均为平均。结果:计算蒲公英根甲醇提取物在L. major作用24、48、72 h后的IC50含量分别为1.04、0.9、0.68µg/ml。暴露72小时后，浓度为1200 μg/ml时，生长抑制率最高(100%)。IC50提取物与两性霉素B药物在24、48、72 h后比较差异有统计学意义(P<0.05)。结论:不同浓度的蒲公英根甲醇提取物对大叶扁桃蚜的生长均有抑制作用，建议对蒲公英根的成分及对大叶扁桃蚜的体内致死作用进行更全面的研究。
{"title":"Evaluation of Antileishmania Effect of Methanolic Extract of Dandelion Root (Taraxacum Officinale) on Leishmanaia Major Promastigotes in Vitro Techniques","authors":"R. Norouzi, Abolghasem Siadatpanah, F. Mirzaei, Ruhollah Fateh, Mohammad Khalifeh Gholi, Seyyed Jafar Adnani Sadati","doi":"10.32598/qums.15.9.377.2","DOIUrl":"https://doi.org/10.32598/qums.15.9.377.2","url":null,"abstract":"Background and Objectives: Cutaneous leishmaniasis is one of the common diseases between humans and animals that is considered a health problem in Iran and many countries around the world. Currently, glucantime is used to treat cutaneous leishmaniasis. Due to its high side effects and resistance, the use of alternative therapies, especially plants and natural compounds, has been highly recommended by researchers. The aim of this study is to investigate the effect of the methanolic extract of dandelion root (Taraxacum officinale) on Leishmania major in vitro techniques. Methods: In this experimental study, the extract was prepared by the Soxhlet method and to evaluate the effect of methanolic extract of dandelion root on L. major parasite at concentrations of 300-1200 mg/ml. Amphotericin B and distilled water were considered as positive and negative controls, respectively. Then, 106 live parasites were added to all tubes, and all groups were kept at 25 ±1 °C. At 24, 48, and 72 hours, the number of live parasites was counted by Trypan Blue using a neobar slide and light microscope (Hemocytometer method). Then Half-maximal inhibitory concentration (IC50) value for the above extract was calculated using SigmaPlot™ 13 software. All steps of the experiment were done in triplicate and the results were considered as average. Results: The IC50 content of methanolic extract of dandelion roots after 24, 48, and 72 hours on L. major were calculated to be 1.04, 0.9, and 0.68 µg/ml. The highest growth inhibition (100%) was observed at a concentration of 1200 μg/ml after 72 hours of exposure. There was a significant difference between the IC50 extract and amphotericin B drug after 24, 48 and 72 hours (P<0.05). Conclusion: Methanolic extract of dandelion root in different concentrations has an inhibitory effect on the growth of L. major and it is suggested that more and more complete studies be performed on the components of this plant and the lethal effect of the parasite in vivo.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75743585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.32598/qums.15.9.2318.1
G. Sharifirad, E. Rahiminia, H. Rahiminia, Fatemeh Kheirollahi, Parisa Sarraf, Sara Rezapooran, Elham Ramezanypoor
Background and Objectives: The most of physical and mental changes occur in childhood, so paying attention to prevention from illnesses among children is from the primary priorities. so that attention to the health status of these people is of particular importance, so we decided to determine the present study Implement the physical health of students in Qom City. Methods: The present study is a descriptive cross-sectional study that was performed in 2016 on 400 students aged 5-7 years who were selected by simple random sampling from 13 schools in Qom City. Data collection tools were “Student Preliminary and Medical Assessment Form” which included weight, height, Body mass index (BMI), hearing and vision impairment and oral problems. Statistical data were analyzed using descriptive and inferential statistics. Results: In the study of physical growth (height and weight), the average height and weight of girls and boys was lower than the average growth standard. On visual and auditory examination of all students, 1.6% had visual impairment in one or both eyes, 0.8% had impaired vision in one or both ears and 86.3% had tooth decay, in terms of pediculosis only 6.3% had pedicures and only 12% had poor nutritional status. Conclusion: According to the results of the present study, in general the state of physical health of students was unfavorable, so in addition to self-care programs, oral hygiene heeding, assessment of visual and auditory health, proper nutrition and exercise is also recommended.
{"title":"Assessing the Physical Health of 5-7 Year Old Students to Qom City in 2016","authors":"G. Sharifirad, E. Rahiminia, H. Rahiminia, Fatemeh Kheirollahi, Parisa Sarraf, Sara Rezapooran, Elham Ramezanypoor","doi":"10.32598/qums.15.9.2318.1","DOIUrl":"https://doi.org/10.32598/qums.15.9.2318.1","url":null,"abstract":"Background and Objectives: The most of physical and mental changes occur in childhood, so paying attention to prevention from illnesses among children is from the primary priorities. so that attention to the health status of these people is of particular importance, so we decided to determine the present study Implement the physical health of students in Qom City. Methods: The present study is a descriptive cross-sectional study that was performed in 2016 on 400 students aged 5-7 years who were selected by simple random sampling from 13 schools in Qom City. Data collection tools were “Student Preliminary and Medical Assessment Form” which included weight, height, Body mass index (BMI), hearing and vision impairment and oral problems. Statistical data were analyzed using descriptive and inferential statistics. Results: In the study of physical growth (height and weight), the average height and weight of girls and boys was lower than the average growth standard. On visual and auditory examination of all students, 1.6% had visual impairment in one or both eyes, 0.8% had impaired vision in one or both ears and 86.3% had tooth decay, in terms of pediculosis only 6.3% had pedicures and only 12% had poor nutritional status. Conclusion: According to the results of the present study, in general the state of physical health of students was unfavorable, so in addition to self-care programs, oral hygiene heeding, assessment of visual and auditory health, proper nutrition and exercise is also recommended.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85498511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.32598/qums.15.9.2466.1
M. Dehesh, N. Rejeh, Seyyed Davood Tadrisi, A. Tayebi
Background and Objectives: The elderly patients undergoing hemodialysis are at higher risk for falling and its critical outcomes compared with their healthy counterparts. Falls can lead to the individual becoming fearful of experiencing subsequent falls. Yet little is known about the fear of falling in this high risk population. The present study aimed to assess the fear of falling and its contributing factors in the elderly patients with the history of falls undergoing hemodialysis, who referred to the hospitals in Tehran city in 2021 Methods: In this descriptive analytic cross sectional study, which was performed on 197 patients undergoing hemodialysis referring to Tehran city hospitals in 2021. Patients were selected with convenience sampling. The instruments for data collection was demographic characteristics scale, Falls Efficacy Scale-International (FES-I) . Data analysis was done by using descriptive and inferential tests and was shown via SPSS v.21 software. Results: Mean age of participants was 70.02±8.12 years and (63.5%) were men. Mean Falls Efficacy Scale-International Score was 35.29±13.54 points, which is consistent with a high fear of falling. There was consistency between adherence to fear of falling and demographic information (P<0.05). Conclusion: According to the results, the frequency of fear of falling in the elderly patients with the history of falls undergoing hemodialysis was significantly high. In older hemodialysis patients, fear of falling is a likely contributor to the occurrence of falls. Future researches should explore reducing the fear of falling as a preventive factor for falls in elderly hemodialysis patients.
{"title":"Fear of Falls and Related Factors in The Elderly Undergoing Dialysis Referred to Hospitals in Tehran 2021","authors":"M. Dehesh, N. Rejeh, Seyyed Davood Tadrisi, A. Tayebi","doi":"10.32598/qums.15.9.2466.1","DOIUrl":"https://doi.org/10.32598/qums.15.9.2466.1","url":null,"abstract":"Background and Objectives: The elderly patients undergoing hemodialysis are at higher risk for falling and its critical outcomes compared with their healthy counterparts. Falls can lead to the individual becoming fearful of experiencing subsequent falls. Yet little is known about the fear of falling in this high risk population. The present study aimed to assess the fear of falling and its contributing factors in the elderly patients with the history of falls undergoing hemodialysis, who referred to the hospitals in Tehran city in 2021 Methods: In this descriptive analytic cross sectional study, which was performed on 197 patients undergoing hemodialysis referring to Tehran city hospitals in 2021. Patients were selected with convenience sampling. The instruments for data collection was demographic characteristics scale, Falls Efficacy Scale-International (FES-I) . Data analysis was done by using descriptive and inferential tests and was shown via SPSS v.21 software. Results: Mean age of participants was 70.02±8.12 years and (63.5%) were men. Mean Falls Efficacy Scale-International Score was 35.29±13.54 points, which is consistent with a high fear of falling. There was consistency between adherence to fear of falling and demographic information (P<0.05). Conclusion: According to the results, the frequency of fear of falling in the elderly patients with the history of falls undergoing hemodialysis was significantly high. In older hemodialysis patients, fear of falling is a likely contributor to the occurrence of falls. Future researches should explore reducing the fear of falling as a preventive factor for falls in elderly hemodialysis patients.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88733956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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