Pub Date : 2025-11-15DOI: 10.1016/j.psyneuen.2025.107692
Jelena Dukic , Alexandra Johann , Mirka Henninger , Ulrike Ehlert
Background
The maternal hypothalamic-pituitary-adrenal (HPA) axis undergoes substantial physiological changes during pregnancy and postpartum, reflected in altered cortisol secretion patterns. However, research has shown considerable heterogeneity in cortisol patterns across the peripartum period and in part contradictory findings. Individual courses of cortisol secretion and their determinants remain poorly understood.
Methods
In a longitudinal cohort of 127 healthy pregnant women, we assessed salivary cortisol at five time points from late pregnancy (gestational weeks 34–36 and 40) to eight weeks postpartum. Group-based trajectory modeling was applied to three cortisol measures to identify distinct cortisol secretion patterns. Associations with sociodemographic and psychological covariates were explored.
Results
Across all cortisol indices, two distinct trajectory groups emerged. The majority of women (79–86 %) exhibited stable, relatively lower cortisol levels during late pregnancy and postpartum, while a smaller subgroup (14–21 %) exhibited a consistently elevated and more variable cortisol trajectory. Trajectory groups showed high classification stability (98–99 %), but no sociodemographic or psychological variables significantly predicted group membership.
Conclusions
Our findings reveal two distinct maternal cortisol trajectory subgroups across the peripartum period, reflecting heterogeneity in HPA axis regulation. The lack of significant associations with the measured covariates raises the possibility that unmeasured mechanisms, such as genetic or epigenetic influences, may contribute to these patterns. These distinct cortisol trajectories may reflect differing modes of neuroendocrine regulation, offering a potential explanation for inconsistencies in prior peripartum cortisol research.
{"title":"Heterogeneous cortisol patterns during the peripartum: Insights from a longitudinal trajectory analysis","authors":"Jelena Dukic , Alexandra Johann , Mirka Henninger , Ulrike Ehlert","doi":"10.1016/j.psyneuen.2025.107692","DOIUrl":"10.1016/j.psyneuen.2025.107692","url":null,"abstract":"<div><h3>Background</h3><div>The maternal hypothalamic-pituitary-adrenal (HPA) axis undergoes substantial physiological changes during pregnancy and postpartum, reflected in altered cortisol secretion patterns. However, research has shown considerable heterogeneity in cortisol patterns across the peripartum period and in part contradictory findings. Individual courses of cortisol secretion and their determinants remain poorly understood.</div></div><div><h3>Methods</h3><div>In a longitudinal cohort of 127 healthy pregnant women, we assessed salivary cortisol at five time points from late pregnancy (gestational weeks 34–36 and 40) to eight weeks postpartum. Group-based trajectory modeling was applied to three cortisol measures to identify distinct cortisol secretion patterns. Associations with sociodemographic and psychological covariates were explored.</div></div><div><h3>Results</h3><div>Across all cortisol indices, two distinct trajectory groups emerged. The majority of women (79–86 %) exhibited stable, relatively lower cortisol levels during late pregnancy and postpartum, while a smaller subgroup (14–21 %) exhibited a consistently elevated and more variable cortisol trajectory. Trajectory groups showed high classification stability (98–99 %), but no sociodemographic or psychological variables significantly predicted group membership.</div></div><div><h3>Conclusions</h3><div>Our findings reveal two distinct maternal cortisol trajectory subgroups across the peripartum period, reflecting heterogeneity in HPA axis regulation. The lack of significant associations with the measured covariates raises the possibility that unmeasured mechanisms, such as genetic or epigenetic influences, may contribute to these patterns. These distinct cortisol trajectories may reflect differing modes of neuroendocrine regulation, offering a potential explanation for inconsistencies in prior peripartum cortisol research.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"184 ","pages":"Article 107692"},"PeriodicalIF":3.6,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145574159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-14DOI: 10.1016/j.psyneuen.2025.107687
Jiaxuan Liu , Andrew Ratanatharathorn , Anat Yaskolka Meir , Audrey R. Murchland , Yiwen Zhu , Andrea L. Roberts , Rebecca B. Lawn , Jennifer A. Sumner , Sebastien Haneuse , Liming Liang , Laura D. Kubzansky , Karestan C. Koenen , Lori B. Chibnik
{"title":"Corrigendum to “Posttraumatic stress disorder and epigenetic signatures of inflammation in middle-aged women” [Psychoneuroendocrinology 182 (2025) 107654]","authors":"Jiaxuan Liu , Andrew Ratanatharathorn , Anat Yaskolka Meir , Audrey R. Murchland , Yiwen Zhu , Andrea L. Roberts , Rebecca B. Lawn , Jennifer A. Sumner , Sebastien Haneuse , Liming Liang , Laura D. Kubzansky , Karestan C. Koenen , Lori B. Chibnik","doi":"10.1016/j.psyneuen.2025.107687","DOIUrl":"10.1016/j.psyneuen.2025.107687","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"184 ","pages":"Article 107687"},"PeriodicalIF":3.6,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145527972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study examined the effectiveness of Eye Movement Desensitization and Reprocessing (EMDR) in improving psychological functioning and modulating immune markers in adults with Hashimoto’s thyroiditis (HT), a chronic autoimmune disorder increasingly linked to early trauma.
Method
In a randomized controlled trial, 91 adults with HT were assigned to EMDR plus treatment-as-usual (TAU), placebo plus TAU, or TAU alone. The EMDR protocol focused on processing ten distressing memories predating illness onset. Outcomes included anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-TG) levels, and measures of depression, anxiety, stress, dissociation, alexithymia, trait anger, emotion regulation, and quality of life, assessed at baseline, posttreatment, and 3-month follow-up.
Results
EMDR led to significant improvements in dissociation, alexithymia, depression, anxiety, stress, trait anger, and emotion regulation, along with enhanced quality of life. These effects were maintained at follow-up and generally exceeded those of placebo or TAU. A significant reduction in anti-TPO levels was also observed in the EMDR group, although between-group effects at follow-up did not remain significant after correction for multiple comparisons. No significant differences were found in anti-TG levels.
Conclusion
EMDR may offer a clinically relevant adjunctive intervention for individuals with HT, reducing psychological distress and potentially influencing immune activity. Findings on immunomodulation are preliminary and warrant further investigation in larger trials.
{"title":"Psychological and immunological benefits of eye movement desensitization and reprocessing in hashimoto thyroiditis: Preliminary findings from a randomized controlled trial","authors":"Maria-Magdalena Macarenco , Cristian Opariuc-Dan , Teodora Georgescu , Livia Căciuloiu","doi":"10.1016/j.psyneuen.2025.107695","DOIUrl":"10.1016/j.psyneuen.2025.107695","url":null,"abstract":"<div><h3>Objective</h3><div>This study examined the effectiveness of Eye Movement Desensitization and Reprocessing (EMDR) in improving psychological functioning and modulating immune markers in adults with Hashimoto’s thyroiditis (HT), a chronic autoimmune disorder increasingly linked to early trauma.</div></div><div><h3>Method</h3><div>In a randomized controlled trial, 91 adults with HT were assigned to EMDR plus treatment-as-usual (TAU), placebo plus TAU, or TAU alone. The EMDR protocol focused on processing ten distressing memories predating illness onset. Outcomes included anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-TG) levels, and measures of depression, anxiety, stress, dissociation, alexithymia, trait anger, emotion regulation, and quality of life, assessed at baseline, posttreatment, and 3-month follow-up.</div></div><div><h3>Results</h3><div>EMDR led to significant improvements in dissociation, alexithymia, depression, anxiety, stress, trait anger, and emotion regulation, along with enhanced quality of life. These effects were maintained at follow-up and generally exceeded those of placebo or TAU. A significant reduction in anti-TPO levels was also observed in the EMDR group, although between-group effects at follow-up did not remain significant after correction for multiple comparisons. No significant differences were found in anti-TG levels.</div></div><div><h3>Conclusion</h3><div>EMDR may offer a clinically relevant adjunctive intervention for individuals with HT, reducing psychological distress and potentially influencing immune activity. Findings on immunomodulation are preliminary and warrant further investigation in larger trials.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"184 ","pages":"Article 107695"},"PeriodicalIF":3.6,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-13DOI: 10.1016/j.psyneuen.2025.107686
Xiaoxiao Fan , Yi Wei , Tianzi Zang , Yiming Tu , Linxia Liu , Huan Tian , Xiaoxiao Li , Hairong Cheng , Jinbing Bai , Yanqun Liu
Objectives
The role of the gut microbiota and short-chain fatty acids (SCFAs) in psychiatric disorders in pregnant women has not been fully elucidated. Therefore, this study aimed to investigate the association between the gut microbiota and its metabolite SCFAs and prenatal depression, pregnancy-related anxiety, and prenatal combined depression and anxiety.
Methods
In total 200 pregnant women in the third trimester were recruited for this study. The Edinburgh Postnatal Depression Scale and Pregnancy-Related Anxiety Questionnaire Revised-2 were used to evaluate pregnant women’s anxiety and depression, and stool samples were collected for gut microbiome and SCFAs.
Results
This study found that reduced abundance of Allobaculum and Cetobacterium were associated with pregnancy-related anxiety in women. Furthermore, the enrichment of Anaerofustis, Gemella, and Staphylococcus and the reduction of Tyzzerella and unclassified_f_UCG-011 were associated with prenatal depression. This study was the first to indicate that women with comorbid prenatal anxiety and depression share similarities in gut microbiota and SCFAs with women with prenatal depression (Anaerofustis, Gemella, Staphylococcus, Tyzzerella, and isohexanoic acid). This study also found that certain gut microbial profiles were associated with prenatal comorbid anxiety and depression. While receiver operating characteristic analysis suggests a limited ability of the gut microbiota alone to predict prenatal psychological distress problems, the integration of phenotypic variables into the model significantly improved the model’s predictive ability.
Conclusion
Our findings suggested that dysbiosis of gut microbiota and SCFAs are associated with prenatal psychiatric disorders. Alterations of the gut microbiota may have the potential as biomarkers for distinguishing prenatal psychiatric disorders.
{"title":"Gut feelings: Dysbiosis of gut microbiota and short-chain fatty acids associated with prenatal depression, pregnancy-related anxiety, and prenatal combined depression and anxiety","authors":"Xiaoxiao Fan , Yi Wei , Tianzi Zang , Yiming Tu , Linxia Liu , Huan Tian , Xiaoxiao Li , Hairong Cheng , Jinbing Bai , Yanqun Liu","doi":"10.1016/j.psyneuen.2025.107686","DOIUrl":"10.1016/j.psyneuen.2025.107686","url":null,"abstract":"<div><h3>Objectives</h3><div>The role of the gut microbiota and short-chain fatty acids (SCFAs) in psychiatric disorders in pregnant women has not been fully elucidated. Therefore, this study aimed to investigate the association between the gut microbiota and its metabolite SCFAs and prenatal depression, pregnancy-related anxiety, and prenatal combined depression and anxiety.</div></div><div><h3>Methods</h3><div>In total 200 pregnant women in the third trimester were recruited for this study. The Edinburgh Postnatal Depression Scale and Pregnancy-Related Anxiety Questionnaire Revised-2 were used to evaluate pregnant women’s anxiety and depression, and stool samples were collected for gut microbiome and SCFAs.</div></div><div><h3>Results</h3><div>This study found that reduced abundance of <em>Allobaculum</em> and <em>Cetobacterium</em> were associated with pregnancy-related anxiety in women. Furthermore, the enrichment of <em>Anaerofustis</em>, <em>Gemella</em>, and <em>Staphylococcus</em> and the reduction of <em>Tyzzerella</em> and <em>unclassified_f_UCG-011</em> were associated with prenatal depression. This study was the first to indicate that women with comorbid prenatal anxiety and depression share similarities in gut microbiota and SCFAs with women with prenatal depression (<em>Anaerofustis</em>, <em>Gemella</em>, <em>Staphylococcus</em>, <em>Tyzzerella,</em> and isohexanoic acid). This study also found that certain gut microbial profiles were associated with prenatal comorbid anxiety and depression. While receiver operating characteristic analysis suggests a limited ability of the gut microbiota alone to predict prenatal psychological distress problems, the integration of phenotypic variables into the model significantly improved the model’s predictive ability.</div></div><div><h3>Conclusion</h3><div>Our findings suggested that dysbiosis of gut microbiota and SCFAs are associated with prenatal psychiatric disorders. Alterations of the gut microbiota may have the potential as biomarkers for distinguishing prenatal psychiatric disorders.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"184 ","pages":"Article 107686"},"PeriodicalIF":3.6,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145557398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-13DOI: 10.1016/j.psyneuen.2025.107693
Maitri Jain , Emily Sokol , Elizabeth Freehling , Sneha Kamath , Renée Lajiness-O'Neill , Angela D. Staples , Jamie M. Lawler
Importance
Although parent-child cortisol synchrony is essential for the development of children’s socio-emotional development, the research findings on what affects this synchrony are unclear. This lack of clarity makes it difficult to pinpoint the best areas to target when creating interventions to help improve synchrony between parents and their children.
Objective
We aimed to characterize the literature on parent-child cortisol synchrony and how various family-related risks and protective factors were associated with parent-child cortisol synchrony.
Evidence review
We searched 4 databases (CINAHL, PsycINFO, PubMed, and Web of Science) on August 25th, 2025. Backward and forward citation searching was also conducted. Eligible articles a) were peer-reviewed articles/theses/dissertations published in the English language, b) assessed children between 6 months and 8 years for diurnal cortisol, and between 0 months and 8 years for cortisol reactivity, c) included majority of children free of neurological, genetic, or major psychiatric disorders and born full-term, d) included parents with a mean age above 18 years, where the majority were free of neurological or genetic disorders, e) collected at least 2 salivary cortisol samples from both parent and child, in either home or lab, f) for cortisol reactivity, collected at least one saliva sample each before and after a challenging task, g) collected 2 saliva samples on the same day for diurnal cortisol, and h) reported any statistical association between parent and child cortisol. We used the Quality Assessment with Diverse Studies Tool for quality analysis.
Findings
We identified 33 unique studies, including a total of 5206 participants. All studies were observational, with 7 longitudinal studies. The scarce literature suggested positive child-to-parent synchrony in families without risk factors, but synchrony was absent or reduced in families with risk factors. Protective factors (e.g., parental sensitivity) led to more adaptive synchrony in parent-child dyads.
Conclusions and relevance
While the existing research suggested that parent-child cortisol synchrony is affected by both family risk and protective factors, too few studies existed to draw strong conclusions. More research is essential to develop better interventions for improving parent-child synchrony.
重要性：虽然亲子皮质醇同步性对儿童社会情感发展至关重要，但影响亲子皮质醇同步性的因素研究结果尚不清楚。由于缺乏明确性，在制定干预措施以帮助改善父母与子女之间的同步时，很难确定最佳目标领域。目的：我们旨在描述亲子皮质醇同步的文献特征，以及各种家庭相关风险和保护因素如何与亲子皮质醇同步相关。我们于2025年8月25日检索了4个数据库（CINAHL、PsycINFO、PubMed和Web of Science）。并进行了前后引文检索。符合条件的文章a)以英语发表的同行评审的文章/论文/论文，b)评估6个月至8岁儿童的皮质醇日变化，以及0个月至8岁儿童的皮质醇反应性，c)包括大多数无神经、遗传或主要精神疾病且足月出生的儿童，d)包括平均年龄在18岁以上的父母，其中大多数无神经或遗传疾病。E)在家中或实验室从父母和孩子身上收集至少2个唾液皮质醇样本，f)皮质醇反应性，在具有挑战性的任务之前和之后分别收集至少一个唾液样本，g)在同一天收集2个唾液样本用于每日皮质醇，h)报告父母和孩子皮质醇之间的任何统计关联。我们使用多样化研究质量评估工具进行质量分析。研究结果：我们确定了33项独特的研究，包括5206名参与者。所有研究均为观察性研究，其中7项为纵向研究。很少的文献表明，在没有危险因素的家庭中，孩子与父母的同步性是积极的，但在有危险因素的家庭中，同步性是缺失的或降低的。保护因素（例如，父母敏感性）导致亲子二代更强的适应性同步。结论及相关性：虽然现有研究表明亲子皮质醇同步受家庭风险因素和保护因素的影响，但研究太少，无法得出强有力的结论。更多的研究是必要的，以制定更好的干预措施，以改善亲子同步。
{"title":"Parent-child salivary cortisol synchrony in early childhood: A systematic review","authors":"Maitri Jain , Emily Sokol , Elizabeth Freehling , Sneha Kamath , Renée Lajiness-O'Neill , Angela D. Staples , Jamie M. Lawler","doi":"10.1016/j.psyneuen.2025.107693","DOIUrl":"10.1016/j.psyneuen.2025.107693","url":null,"abstract":"<div><h3>Importance</h3><div>Although parent-child cortisol synchrony is essential for the development of children’s socio-emotional development, the research findings on what affects this synchrony are unclear. This lack of clarity makes it difficult to pinpoint the best areas to target when creating interventions to help improve synchrony between parents and their children.</div></div><div><h3>Objective</h3><div>We aimed to characterize the literature on parent-child cortisol synchrony and how various family-related risks and protective factors were associated with parent-child cortisol synchrony.</div></div><div><h3>Evidence review</h3><div>We searched 4 databases (CINAHL, PsycINFO, PubMed, and Web of Science) on August 25th, 2025. Backward and forward citation searching was also conducted. Eligible articles a) were peer-reviewed articles/theses/dissertations published in the English language, b) assessed children between 6 months and 8 years for diurnal cortisol, and between 0 months and 8 years for cortisol reactivity, c) included majority of children free of neurological, genetic, or major psychiatric disorders and born full-term, d) included parents with a mean age above 18 years, where the majority were free of neurological or genetic disorders, e) collected at least 2 salivary cortisol samples from both parent and child, in either home or lab, f) for cortisol reactivity, collected at least one saliva sample each before and after a challenging task, g) collected 2 saliva samples on the same day for diurnal cortisol, and h) reported any statistical association between parent and child cortisol. We used the Quality Assessment with Diverse Studies Tool for quality analysis.</div></div><div><h3>Findings</h3><div>We identified 33 unique studies, including a total of 5206 participants. All studies were observational, with 7 longitudinal studies. The scarce literature suggested positive child-to-parent synchrony in families without risk factors, but synchrony was absent or reduced in families with risk factors. Protective factors (e.g., parental sensitivity) led to more adaptive synchrony in parent-child dyads.</div></div><div><h3>Conclusions and relevance</h3><div>While the existing research suggested that parent-child cortisol synchrony is affected by both family risk and protective factors, too few studies existed to draw strong conclusions. More research is essential to develop better interventions for improving parent-child synchrony.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"184 ","pages":"Article 107693"},"PeriodicalIF":3.6,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145605522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-13DOI: 10.1016/j.psyneuen.2025.107694
Gabriel Zieff , Taylyn Jameson , Alison Nutini , Ashley M. Battaglini , Ellen Jopling , Bronwen Grocott , Katerina Rnic , Eli Puterman , Joelle LeMoult
Introduction
Self-compassion is an adaptive means of relating to oneself that encompasses elements of self-kindness, common humanity, and mindfulness. Self-compassion has positive associations with health and may dampen biological and psychological stress responses, which would be particularly helpful for those with a history of early life adversity. The purpose of this study was to determine i) the association of trait self-compassion with cortisol and affective responses to an acute psychosocial stressor among early adolescents, and ii) whether this association differed by exposure to early life adversity (e.g., abuse, neglect).
Methods
Eighty-three early adolescents (M = 12.86 years; 47 % girls, 1 % non-binary) self-reported their trait self-compassion, completed a structured interview-based assessment to assess threat- and deprivation-related exposures to early life adversity, and underwent a psychosocial laboratory stressor (Trier Social Stress Test for Children; TSST-C). Salivary cortisol and self-reported positive and negative affect were measured at six timepoints before, during, and for 30 min following the stressor. We tested associations of self-compassion with trajectories (reactivity, recovery) and total levels (area under the curve with respect to ground; AUCg) of cortisol and positive and negative affect across the TSST-C, as well as moderating effects of early life adversity. Hierarchical linear models were used to test trajectories, and linear regression was used to test AUCg, with unstandardized (B) and standardized beta coefficients (β) reported, respectively.
Results
Self-compassion was not associated with total cortisol levels or trajectories of cortisol, positive affect, or negative affect (all p > 0.057). However, greater self-compassion was associated with higher sample 1 positive affect, B = 1.815, t(71) = 2.84, p = .006, and greater total positive affect levels, β = 0.411, t(62) = 3.90, p < .001. Similarly, self-compassion was associated with lower sample 1 negative affect, B = -1.261, t(72) = -2.35, p = 0.022, and less total negative affect levels, β = -0.269, t(75) = -2.45, p = 0.017. Additionally, sensitivity analyses indicated that at higher levels of early-life threat exposure, greater self-compassion was associated with higher sample 1 positive affect.
Conclusion
Among adolescents – including those exposed to threat-related forms of early life adversity– self-compassion may impart more general, diffuse beneficial effects on affect rather than buffering affective or cortisol responses to an acute stressor.
自我同情是一种与自己相关的适应性手段，包含了自我仁慈、共同人性和正念的元素。自我同情与健康有积极的联系，可能会抑制生理和心理上的压力反应，这对那些早年经历过逆境的人尤其有帮助。本研究的目的是确定i)特质自我同情与皮质醇和对早期青少年急性社会心理压力的情感反应的关联，以及ii)这种关联是否因早期生活逆境（如虐待，忽视）而不同。方法：83名早期青少年（M = 12.86岁；47 %女孩，1 %非二性别）自我报告了他们的自我同情特质，完成了基于结构化访谈的评估，以评估早期生活逆境中与威胁和剥夺相关的暴露，并进行了心理社会实验室压力源（Trier Social Stress Test for Children; TSST-C）。唾液皮质醇和自我报告的积极和消极影响在压力源之前，期间和30 min后的六个时间点进行测量。我们测试了自我同情与皮质醇的轨迹（反应性、恢复）、总水平（相对于地面的曲线下面积；AUCg）、积极和消极情绪在TSST-C中的关联，以及早期生活逆境的调节作用。采用层次线性模型检验轨迹，采用线性回归检验AUCg，分别报告了未标准化(B)和标准化β系数（β）。结果：自我同情与总皮质醇水平或皮质醇轨迹、积极影响、消极影响无关（p均为 > 0.057）。然而，更大的自我同情与更高的样本1积极情绪相关，B = 1.815,t（71） = 2.84,p = 。β = 0.411,t（62） = 3.90，p 结论：在青少年中，包括那些早期经历过威胁相关逆境的青少年，自我同情可能会对情感产生更普遍、更广泛的有益影响，而不是缓冲对急性压力源的情感或皮质醇反应。
{"title":"Self-compassion and stress responses among early adolescents","authors":"Gabriel Zieff , Taylyn Jameson , Alison Nutini , Ashley M. Battaglini , Ellen Jopling , Bronwen Grocott , Katerina Rnic , Eli Puterman , Joelle LeMoult","doi":"10.1016/j.psyneuen.2025.107694","DOIUrl":"10.1016/j.psyneuen.2025.107694","url":null,"abstract":"<div><h3>Introduction</h3><div>Self-compassion is an adaptive means of relating to oneself that encompasses elements of self-kindness, common humanity, and mindfulness. Self-compassion has positive associations with health and may dampen biological and psychological stress responses, which would be particularly helpful for those with a history of early life adversity. The purpose of this study was to determine i) the association of trait self-compassion with cortisol and affective responses to an acute psychosocial stressor among early adolescents, and ii) whether this association differed by exposure to early life adversity (e.g., abuse, neglect).</div></div><div><h3>Methods</h3><div>Eighty-three early adolescents (<em>M</em> = 12.86 years; 47 % girls, 1 % non-binary) self-reported their trait self-compassion, completed a structured interview-based assessment to assess threat- and deprivation-related exposures to early life adversity, and underwent a psychosocial laboratory stressor (Trier Social Stress Test for Children; TSST-C). Salivary cortisol and self-reported positive and negative affect were measured at six timepoints before, during, and for 30 min following the stressor. We tested associations of self-compassion with trajectories (reactivity, recovery) and total levels (area under the curve with respect to ground; AUCg) of cortisol and positive and negative affect across the TSST-C, as well as moderating effects of early life adversity. Hierarchical linear models were used to test trajectories, and linear regression was used to test AUCg, with unstandardized (<em>B</em>) and standardized beta coefficients (<em>β)</em> reported, respectively.</div></div><div><h3>Results</h3><div>Self-compassion was not associated with total cortisol levels or trajectories of cortisol, positive affect, or negative affect (all <em>p</em> > 0.057). However, greater self-compassion was associated with higher sample 1 positive affect, <em>B</em> = 1.815, <em>t</em>(71) = 2.84, <em>p</em> = .006, and greater total positive affect levels, <em>β</em> = 0.411, <em>t</em>(62) = 3.90, <em>p</em> < .001. Similarly, self-compassion was associated with lower sample 1 negative affect, <em>B</em> = -1.261, <em>t</em>(72) = -2.35, <em>p</em> = 0.022, and less total negative affect levels, <em>β</em> = -0.269, <em>t</em>(75) = -2<em>.</em>45, <em>p</em> = 0.017. Additionally, sensitivity analyses indicated that at higher levels of early-life threat exposure, greater self-compassion was associated with higher sample 1 positive affect.</div></div><div><h3>Conclusion</h3><div>Among adolescents – including those exposed to threat-related forms of early life adversity– self-compassion may impart more general, diffuse beneficial effects on affect rather than buffering affective or cortisol responses to an acute stressor.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"184 ","pages":"Article 107694"},"PeriodicalIF":3.6,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-12DOI: 10.1016/j.psyneuen.2025.107689
A-K. Lennartsson , I.H. Jonsdottir
Background
Psychosocial stress has been suggested to contribute to low-grade inflammation, which in turn can, if persisting, increase the risk of developing a wide range of chronic disorders. The aim of this study was to investigate the level of CRP in response to acute psychosocial stress in healthy men and women, whether the responses related to general stress activation. Since it is known that CRP level in general is associated with BMI, we also aimed to investigate whether CRP response during acute stress is related to BMI and overweight.
Method
Thirty men and 19 women, aged 30—50 years (mean age 39 years, SD 5.6 years), were included in the study. The participants underwent the Trier Social Stress Test (TSST), and CRP was measured in serum together with measurements of general stress activation.
Results
CRP levels slightly and temporarily increased in response to acute psychosocial stress. CRP response was positively related to the response of ACTH and cortisol. The CRP response was also positively associated with BMI and the overweight individuals exhibited a larger stress-induced CRP increase.
Conclusion
The results support the idea that stress may contribute to low-grade inflammation, which in turn can constitute one important pathogenic link between stress and adverse health, especially in overweight individuals.
{"title":"High sensitivity C-reactive protein in response to acute stress in healthy men and women","authors":"A-K. Lennartsson , I.H. Jonsdottir","doi":"10.1016/j.psyneuen.2025.107689","DOIUrl":"10.1016/j.psyneuen.2025.107689","url":null,"abstract":"<div><h3>Background</h3><div>Psychosocial stress has been suggested to contribute to low-grade inflammation, which in turn can, if persisting, increase the risk of developing a wide range of chronic disorders. The aim of this study was to investigate the level of CRP in response to acute psychosocial stress in healthy men and women, whether the responses related to general stress activation. Since it is known that CRP level in general is associated with BMI, we also aimed to investigate whether CRP response during acute stress is related to BMI and overweight.</div></div><div><h3>Method</h3><div>Thirty men and 19 women, aged 30—50 years (mean age 39 years, SD 5.6 years), were included in the study. The participants underwent the Trier Social Stress Test (TSST), and CRP was measured in serum together with measurements of general stress activation.</div></div><div><h3>Results</h3><div>CRP levels slightly and temporarily increased in response to acute psychosocial stress. CRP response was positively related to the response of ACTH and cortisol. The CRP response was also positively associated with BMI and the overweight individuals exhibited a larger stress-induced CRP increase.</div></div><div><h3>Conclusion</h3><div>The results support the idea that stress may contribute to low-grade inflammation, which in turn can constitute one important pathogenic link between stress and adverse health, especially in overweight individuals.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"184 ","pages":"Article 107689"},"PeriodicalIF":3.6,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145499994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-12DOI: 10.1016/j.psyneuen.2025.107690
Margo D. Nathan , Primavera A. Spagnolo , Leilah K. Grant , Shadab A. Rahman , Irene Gonsalvez , Jessica Harder , Hannah Kim , Aleta Wiley , Hadine Joffe
Background
The menopausal transition (MT) represents a period of increased risk for depressive symptoms. Emergence of these symptoms may reflect dysregulations in affect caused by fundamental MT characteristics, particularly sleep disturbance, estradiol decline, and vasomotor symptoms (VMS). Using an experimental paradigm mimicking menopause, we examined the effects of MT-related characteristics on affect.
Methods
38 premenopausal women without affective disorders completed a 6-day experimental paradigm comprising 2 nights of unfragmented sleep followed by 3 nights of provoked sleep fragmentation, during the high-estradiol mid-to-late-follicular menstrual phase. A subset (n = 27) repeated the paradigm after leuprolide-suppressed estradiol (low-estradiol). Positive affect (PA) and negative affect (NA) ratings were obtained daily using the Positive and Negative Affect Schedule.
Results
Sleep fragmentation adversely influenced PA and NA acutely after one night of fragmentation (p < 0.007). This effect persisted following 3 nights of sleep fragmentation for NA (p = 0.02), but not PA (p = 0.46). Conversely, estradiol suppression increased PA (p = 0.0.03) but not NA (p = 0.51). In the low-estradiol condition, women who developed VMS trended toward having a more pronounced and sustained reduction in PA over three nights of sleep fragmentation compared to those who did not (p = 0.09).
Conclusions
Our findings show that MT-related characteristics significantly disrupt both positive and negative affect, potentially underlying emergence of depressive symptoms during this reproductive stage. We observed differential effects on positive and negative affect, with sleep fragmentation having a greater effect on NA and estradiol and VMS having a greater effect on PA, suggesting benefit for tailoring interventions that target specific types of affect regulation.
{"title":"Impact of sleep fragmentation and estradiol suppression on positive and negative affect: Results of an experimental model of menopause","authors":"Margo D. Nathan , Primavera A. Spagnolo , Leilah K. Grant , Shadab A. Rahman , Irene Gonsalvez , Jessica Harder , Hannah Kim , Aleta Wiley , Hadine Joffe","doi":"10.1016/j.psyneuen.2025.107690","DOIUrl":"10.1016/j.psyneuen.2025.107690","url":null,"abstract":"<div><h3>Background</h3><div>The menopausal transition (MT) represents a period of increased risk for depressive symptoms. Emergence of these symptoms may reflect dysregulations in affect caused by fundamental MT characteristics, particularly sleep disturbance, estradiol decline, and vasomotor symptoms (VMS). Using an experimental paradigm mimicking menopause, we examined the effects of MT-related characteristics on affect.</div></div><div><h3>Methods</h3><div>38 premenopausal women without affective disorders completed a 6-day experimental paradigm comprising 2 nights of unfragmented sleep followed by 3 nights of provoked sleep fragmentation, during the high-estradiol mid-to-late-follicular menstrual phase. A subset (n = 27) repeated the paradigm after leuprolide-suppressed estradiol (low-estradiol). Positive affect (PA) and negative affect (NA) ratings were obtained daily using the Positive and Negative Affect Schedule.</div></div><div><h3>Results</h3><div>Sleep fragmentation adversely influenced PA and NA acutely after one night of fragmentation (p < 0.007). This effect persisted following 3 nights of sleep fragmentation for NA (p = 0.02), but not PA (p = 0.46). Conversely, estradiol suppression increased PA (p = 0.0.03) but not NA (p = 0.51). In the low-estradiol condition, women who developed VMS trended toward having a more pronounced and sustained reduction in PA over three nights of sleep fragmentation compared to those who did not (p = 0.09).</div></div><div><h3>Conclusions</h3><div>Our findings show that MT-related characteristics significantly disrupt both positive and negative affect, potentially underlying emergence of depressive symptoms during this reproductive stage. We observed differential effects on positive and negative affect, with sleep fragmentation having a greater effect on NA and estradiol and VMS having a greater effect on PA, suggesting benefit for tailoring interventions that target specific types of affect regulation.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"184 ","pages":"Article 107690"},"PeriodicalIF":3.6,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-12DOI: 10.1016/j.psyneuen.2025.107691
Bin Li , Ruixi Ming , Hongzhou Guo
Heat stress (HS), a prevalent occupational and environmental hazard, has increasingly been recognized as a major contributor to multiple physiological disorders. The hypothalamus, a key regulator of thermoregulation and endocrine signaling, is especially susceptible to metabolic and inflammatory disturbances induced by HS. This study investigates the interplay among lipid metabolism, blood–brain barrier (BBB) integrity, and neuroinflammation in the hypothalamus under HS conditions, with a specific focus on apolipoprotein A1 (APOA1) as a potential protective factor. To achieve this, we integrated proteomic and lipidomic analyses with experimental validation in porcine and murine models. Proteomic analysis identified 266 differentially expressed proteins (DEPs) in the hypothalamus following HS, with significant enrichment in lipid metabolism pathways—especially glycerophospholipid (GP) metabolism—in which APOA1 displayed a marked increase. Lipidomic profiling further revealed HS-induced disruptions in phosphatidylcholine (PC), phosphatidylethanolamine (PE), and cardiolipin (CL) metabolism. Additionally, blood–brain barrier integrity was compromised, as evidenced by increased perivascular IgG extravasation, reduced pericyte coverage, and decreased expression of tight junction proteins ZO-1 and Occludin. HS also triggered pronounced neuroinflammation, characterized by elevated levels of iNOS, GFAP, and pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6). Notably, administration of D-4F, an APOA1 mimetic peptide, alleviated blood–brain barrier damage, reduced neuroinflammation, and preserved synaptic integrity, thereby suggesting a neuroprotective role for APOA1 in HS-induced hypothalamic dysfunction. These findings underscore the critical role of lipid metabolism in maintaining hypothalamic homeostasis under HS conditions and position APOA1 as a key regulator with potential therapeutic implications for mitigating HS-related neuroinflammatory and metabolic disturbances.
{"title":"Protective effects of liver-derived apolipoprotein A1 against heat stress-induced hypothalamic lipid metabolism and blood-brain barrier integrity","authors":"Bin Li , Ruixi Ming , Hongzhou Guo","doi":"10.1016/j.psyneuen.2025.107691","DOIUrl":"10.1016/j.psyneuen.2025.107691","url":null,"abstract":"<div><div>Heat stress (HS), a prevalent occupational and environmental hazard, has increasingly been recognized as a major contributor to multiple physiological disorders. The hypothalamus, a key regulator of thermoregulation and endocrine signaling, is especially susceptible to metabolic and inflammatory disturbances induced by HS. This study investigates the interplay among lipid metabolism, blood–brain barrier (BBB) integrity, and neuroinflammation in the hypothalamus under HS conditions, with a specific focus on apolipoprotein A1 (APOA1) as a potential protective factor. To achieve this, we integrated proteomic and lipidomic analyses with experimental validation in porcine and murine models. Proteomic analysis identified 266 differentially expressed proteins (DEPs) in the hypothalamus following HS, with significant enrichment in lipid metabolism pathways—especially glycerophospholipid (GP) metabolism—in which APOA1 displayed a marked increase. Lipidomic profiling further revealed HS-induced disruptions in phosphatidylcholine (PC), phosphatidylethanolamine (PE), and cardiolipin (CL) metabolism. Additionally, blood–brain barrier integrity was compromised, as evidenced by increased perivascular IgG extravasation, reduced pericyte coverage, and decreased expression of tight junction proteins ZO-1 and Occludin. HS also triggered pronounced neuroinflammation, characterized by elevated levels of iNOS, GFAP, and pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6). Notably, administration of D-4F, an APOA1 mimetic peptide, alleviated blood–brain barrier damage, reduced neuroinflammation, and preserved synaptic integrity, thereby suggesting a neuroprotective role for APOA1 in HS-induced hypothalamic dysfunction. These findings underscore the critical role of lipid metabolism in maintaining hypothalamic homeostasis under HS conditions and position APOA1 as a key regulator with potential therapeutic implications for mitigating HS-related neuroinflammatory and metabolic disturbances.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"184 ","pages":"Article 107691"},"PeriodicalIF":3.6,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145557419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-12DOI: 10.1016/j.psyneuen.2025.107688
Meingold H. Chan , Mandy Meijer , Sarah M. Merrill , Maggie P.Y. Fu , David Lin , Julia L. MacIsaac , Jenna L. Riis , Douglas A. Granger , Elizabeth A. Thomas , Michael S. Kobor
Saliva is widely used in biomedical population research, including epigenetic analyses to investigate gene-environment interplay and identify biomarkers. Its minimally invasive collection procedure makes it ideal for studies in pediatric populations. Saliva is a heterogenous tissue composed of immune and buccal epithelial cells (BEC). Amongst the many epigenetic marks, DNA methylation (DNAm) is the most studied in human populations. DNAm profiles are often highly cell type (CT)-specific. CT composition can drive salivary DNAm associations with environments or health as well as epigenetic age acceleration (EAA), which is the discrepancy between chronological and biological age derived from DNAm. To address this, reference-based CT deconvolution and statistical adjustment with estimated CT in DNAm analyses have become a common practice. However, it remains unclear how different CT reference panels—constructed from adult versus pediatric samples—affect DNAm results. Additionally, whether DNAm and EAA associations in saliva primarily originate from immune cells or BECs, or if they persist across saliva samples despite varying CT proportions, still requires more investigations. The current study used salivary DNAm samples obtained from 529 children (mean age=7.26 years, SD=0.26 years) in a community-based cohort, the Family Life Project. Our results demonstrated that the child reference panel outperformed the adult one based on goodness of fit measure and highlighted the impact of estimated CT discrepancies across reference panels on DNAm associations. Upon stratifying the salivary DNAm samples into three subsamples—primarily BECs, primarily immune cells, and an approximately equal mix of both, we found significantly different EAAs across stratified samples when CT proportions were not accounted for. In both the contexts of DNAm and EAA associations, we detected stronger effects of cotinine concentrations, a tobacco smoke-exposure biomarker, in the subsample with primarily immune cells. We discussed the implications of our findings for the interpretation and replication of epigenetic research involving pediatric saliva samples.
{"title":"Not all saliva samples are equal: The role of cellular heterogeneity in DNA methylation and epigenetic age analyses with biological and psychosocial factors","authors":"Meingold H. Chan , Mandy Meijer , Sarah M. Merrill , Maggie P.Y. Fu , David Lin , Julia L. MacIsaac , Jenna L. Riis , Douglas A. Granger , Elizabeth A. Thomas , Michael S. Kobor","doi":"10.1016/j.psyneuen.2025.107688","DOIUrl":"10.1016/j.psyneuen.2025.107688","url":null,"abstract":"<div><div>Saliva is widely used in biomedical population research, including epigenetic analyses to investigate gene-environment interplay and identify biomarkers. Its minimally invasive collection procedure makes it ideal for studies in pediatric populations. Saliva is a heterogenous tissue composed of immune and buccal epithelial cells (BEC). Amongst the many epigenetic marks, DNA methylation (DNAm) is the most studied in human populations. DNAm profiles are often highly cell type (CT)-specific. CT composition can drive salivary DNAm associations with environments or health as well as epigenetic age acceleration (EAA), which is the discrepancy between chronological and biological age derived from DNAm. To address this, reference-based CT deconvolution and statistical adjustment with estimated CT in DNAm analyses have become a common practice. However, it remains unclear how different CT reference panels—constructed from adult versus pediatric samples—affect DNAm results. Additionally, whether DNAm and EAA associations in saliva primarily originate from immune cells or BECs, or if they persist across saliva samples despite varying CT proportions, still requires more investigations. The current study used salivary DNAm samples obtained from 529 children (mean age=7.26 years, SD=0.26 years) in a community-based cohort, the Family Life Project. Our results demonstrated that the child reference panel outperformed the adult one based on goodness of fit measure and highlighted the impact of estimated CT discrepancies across reference panels on DNAm associations. Upon stratifying the salivary DNAm samples into three subsamples—primarily BECs, primarily immune cells, and an approximately equal mix of both, we found significantly different EAAs across stratified samples when CT proportions were not accounted for. In both the contexts of DNAm and EAA associations, we detected stronger effects of cotinine concentrations, a tobacco smoke-exposure biomarker, in the subsample with primarily immune cells. We discussed the implications of our findings for the interpretation and replication of epigenetic research involving pediatric saliva samples.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"184 ","pages":"Article 107688"},"PeriodicalIF":3.6,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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