Psychoneuroendocrinology最新文献

{"title":"Major experiences of perceived discrimination across life and biological aging","authors":"Roma Dhingra ,&nbsp;Abby R. Hillmann ,&nbsp;Rebecca G. Reed","doi":"10.1016/j.psyneuen.2025.107380","DOIUrl":"10.1016/j.psyneuen.2025.107380","url":null,"abstract":"<div><div>Perceived lifetime discrimination may accelerate aspects of biological aging, but it is unknown whether there are life stages during which experiencing discrimination has the greatest biological impacts. In this study, we tested the effects of total forms of perceived lifetime discrimination experienced both across life and in specific lifespan stages on biological aging. Health and Retirement Study participants (N = 2986, M_age=68 years, 46.2 % Male, 73.4 % White) reported most recent experiences of perceived lifetime discrimination events and their years of occurrence; events were summed across one’s life (total forms of perceived lifetime discrimination across life) and in the following life stages: childhood (0–17 years), young adulthood (18−39), midlife (40−59), and late adulthood (60 +). Blood drawn after survey completion (average 5.89 years later) was used to measure biological aging outcomes, including inflammation (CRP, IL-6, and sTNFR-1) and epigenetic age. In multilevel models adjusted for age, sex, BMI, smoking status, and the time interval between completing the discrimination questionnaire and blood draw, those who experienced greater total forms of perceived lifetime discrimination had higher levels of CRP <em>(γ=0.08, p &lt; 0.001</em>) and IL-6 <em>(γ=0.07, p &lt; 0.001)</em>. When testing each life stage in separate models, more perceived lifetime discrimination events in young adulthood were associated with higher IL-6 <em>(γ=0.05, p = 0.015)</em>. When comparing the effects of the life stages within the same model among adults age 45 + (n = 2978), more perceived lifetime discrimination events in young adulthood were independently associated with higher IL-6 <em>(γ=0.07, p = 0.001)</em> and in midlife with higher CRP <em>(γ=0.06, p = 0.011)</em> and IL-6 (<em>γ=0.07, p = 0.002</em>). Perceived lifetime discrimination was not associated with sTNFR-1 or epigenetic age. More perceived lifetime discrimination events – both across one’s life and in certain adult developmental life stages – are associated with higher levels of later-life inflammation. In particular, young adulthood and midlife may be sensitive periods during which experiencing perceived lifetime discrimination has the greatest immunological impacts.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"174 ","pages":"Article 107380"},"PeriodicalIF":3.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143348642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing immunoassay and mass spectrometry techniques for salivary sex hormone analysis","authors":"Alexandra Brouillard ,&nbsp;Lisa-Marie Davignon ,&nbsp;Rebecca Cernik ,&nbsp;Charles-Édouard Giguère ,&nbsp;Helen Findlay ,&nbsp;Robert-Paul Juster ,&nbsp;Sonia J. Lupien ,&nbsp;Marie-France Marin","doi":"10.1016/j.psyneuen.2025.107379","DOIUrl":"10.1016/j.psyneuen.2025.107379","url":null,"abstract":"<div><div>From a confluence of events, our team acquired salivary sex hormone data from two different assays; namely, enzyme-linked immunosorbent immunoassay (ELISA; Salimetrics) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). As previous research has often discussed inter-assay differences but lacked direct comparative data for these specific hormones in saliva, this paper compared both techniques on their ability to accurately quantify concentrations of estradiol, progesterone, and testosterone in healthy young adults (72 combined oral contraceptive [COC] users, 99 naturally cycling [NC] women in the early follicular and pre-ovulatory phases, and 47 men). Using multivariate and computational approaches, our results converged and showed poor performance of ELISA for measuring salivary sex hormones, with estradiol and progesterone being much less valid than testosterone. Despite its challenges with quantification, LC-MS/MS was found to be superior. Our study underscores the importance of methodological rigor in sex steroid hormone assay techniques, highlighting LC-MS/MS as a more reliable option compared to ELISA for salivary sex hormone quantification in healthy adults. These findings contribute to the ongoing dialogue in the field concerning the validity and reproducibility of scientific discoveries. Indeed, accurate measurement is crucial for generating reliable findings regarding the intricate relationships between hormones, brain, behavior, and mental health.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"174 ","pages":"Article 107379"},"PeriodicalIF":3.4,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortisol and ACTH response to Dex/CRH testing and 24-hour urine free cortisol levels in women with and without premenstrual dysphoric disorder","authors":"Constance X. Zou ,&nbsp;Gioia M. Guerrieri ,&nbsp;Pedro E. Martinez ,&nbsp;Xiaobai Li ,&nbsp;Rivka Ben Dor ,&nbsp;Rhasaan T.M. Bovell ,&nbsp;Jessica M. Naredo Rojas ,&nbsp;Peggy McCluggage ,&nbsp;Natalie Kress ,&nbsp;Lynnette K. Neiman ,&nbsp;David R. Rubinow ,&nbsp;Peter J. Schmidt","doi":"10.1016/j.psyneuen.2024.107250","DOIUrl":"10.1016/j.psyneuen.2024.107250","url":null,"abstract":"<div><div>Hyperactive and hyperreactive HPA axis functions are frequently reported in depressive disorders, particularly in major depression. However, research into HPA axis function in women with premenstrual dysphoric disorder (PMDD), which is also classified as a depressive disorder, has shown inconsistent results. This study aimed to characterize the HPA axis in women with PMDD using the combined dexamethasone suppression and CRH stimulation (Dex/CRH) test, alongside measurements of 24-hour urine free cortisol (UFC). We enrolled 26 women with prospectively confirmed PMDD and 25 asymptomatic controls (ACs), testing them during the mid-follicular and luteal phases of the menstrual cycle. The primary outcomes included serial plasma cortisol and ACTH levels, their area-under-the-curve (AUC), and 24-hour UFC levels. We utilized a mixed model to compare serial cortisol and ACTH levels, and the Wilcoxon Signed Rank test for comparing UFC levels and cortisol and ACTH AUC. No significant effects related to diagnosis or menstrual cycle phase were observed on plasma cortisol or ACTH levels (from time 0 to +75 minutes), nor on the AUCs of plasma cortisol or ACTH (p &gt; 0.05 for all comparisons). Notably, the PMDD group displayed significantly lower 24-hour UFC levels compared to the AC group during both the follicular and luteal phases (p = 0.0004 and p = 0.0007, respectively). The observed hyposecretion of cortisol in the PMDD group suggests a pathophysiology distinct from other depressive disorders, possibly aligning more closely with stress disorders such as PTSD. The unique symptom profile of PMDD, marked by significant irritability and a more rapid response to antidepressant treatment than is typical in major depression, further supports considering an alternative classification.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107250"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Semi‐Virtual Trier Social Stress Test (SV-TSST)","authors":"Melissa Miller,&nbsp;Madeline Divine,&nbsp;Ciara McAfee,&nbsp;Robin Brown,&nbsp;Shelby Sears,&nbsp;Cole Krautkramer,&nbsp;Rhea Gogia,&nbsp;Robert A. Josephs,&nbsp;Frances A. Champagne","doi":"10.1016/j.psyneuen.2024.107267","DOIUrl":"10.1016/j.psyneuen.2024.107267","url":null,"abstract":"<div><div>The Trier Social Stress Test (TSST) is a strategy for inducing acute psychological stress and increases in glucocorticoid levels. Here we describe the methodology and implementation of a Semi-Virtual Trier Social Stress Test (SV-TSST) which combines the control of a laboratory environment with reduced need for in-person logistical support and enhanced social distancing without the need for specialized equipment. During the SV-TSST, the participant is guided through the baseline, anticipatory, challenge, and recovery phases of the test by an in-person experimenter. Confederate judges involved in the challenge phase of the protocol connect with the participant via live video teleconference. Fifty-five healthy male and female participants aged 18–25 completed measures of self-report stress and provided saliva samples for cortisol assay throughout the SV-TSST session. The SV-TSST protocol was found to induce a significant acute increase in subjective psychological stress and salivary cortisol, with elevated psychological stress in SV-TSST female compared to male participants. Results indicate that the SV-TSST can be implemented as protocol for acute stress induction in a within-subject design that can serve as an alternative to classic, virtual, and virtual reality adaptations of this methodology.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107267"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic stress induces depression-like behavior in rats through affecting brain mitochondrial function and inflammation","authors":"Liyuan Wang ,&nbsp;Yongjun Xu ,&nbsp;Mengruo Jiang ,&nbsp;Mengqi Wang ,&nbsp;Meijiao Ji ,&nbsp;Xin Xie ,&nbsp;Hui Sheng","doi":"10.1016/j.psyneuen.2024.107261","DOIUrl":"10.1016/j.psyneuen.2024.107261","url":null,"abstract":"<div><div>Chronic stress is involved in pathophysiology of depression, and causes some neurochemical alterations in brain. Both mitochondrial dysfunction and neuroinflammation are implicated in mediating the depression-like behavior. The objectives of present study were, at first, to confirm that chronic unpredictable mild stress (CUMS) induces depression-like behavior and alters mitochondrial function and inflammatory responses within the brain, and then to explore the role of mitochondria in the development of this depression-like behavior. It has been found that CUMS exposure induced depression-like behavior, mitochondrial dysfunction, increased IL-1, IL-6, IFN-γ and TNF-α levels in hippocampus and PFC. Moreover, the level of ATP, the key index of mitochondrial function, was inversely correlated with the levels of proinflammatory cytokine. Intracerebroventricular (ICV) injection of the mitochondrial targeted antioxidant MnTBAP significantly alleviated depression-like behavior in CUMS group. These findings suggested that CUMS results in depression-like behavior, mitochondrial dysfunction as well as neuroinflammation, and mitochondria dysfunction contributes to depression-like behavior caused by CUMS.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107261"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortisol and C-reactive protein (CRP) regulation in severe mental disorders","authors":"Amina Inova ,&nbsp;Viktoria Birkenæs ,&nbsp;Daniel S. Quintana ,&nbsp;Monica B.E.G. Ormerod ,&nbsp;Torill Ueland ,&nbsp;Thor Ueland ,&nbsp;Srdjan Djurovic ,&nbsp;Ole Andreassen ,&nbsp;Nils Eiel Steen ,&nbsp;Monica Aas","doi":"10.1016/j.psyneuen.2024.107272","DOIUrl":"10.1016/j.psyneuen.2024.107272","url":null,"abstract":"<div><h3>Background</h3><div>People with schizophrenia (SZ) and bipolar disorder (BD) show abnormalities in the biological stress system and low-grade inflammation. However, whether the hypothalamic-pituitary-adrenal (HPA) axis-immune regulation is disrupted in SZ and BD, is yet to be determined.</div></div><div><h3>Methods</h3><div>Cortisol and C-reactive protein (CRP) were measured in blood samples collected at or before 10 am in participants with SZ (N = 257), BD (N = 153), and healthy controls (N = 40). Cortisol/CRP ratio was calculated as an indicator of the balance between HPA axis activity and inflammatory activity, called HPA axis-immune regulation. Global functioning and symptom levels were obtained using the Global Assessment of Functioning (GAF) Scale and Positive and Negative Syndrome Scale (PANSS). Standardized neuropsychological tests were used to assess cognitive function. All analyses were adjusted for demographic variables (age and sex) and the time of blood sampling.</div></div><div><h3>Results</h3><div>Participants with a SZ or BD diagnosis had lower cortisol/CRP ratios (F=5.93, p = 0.003) compared to healthy controls. The difference was no longer statistically significant (p &gt; 0.1) when BMI was added as a covariate to the model. Within patients, those on psychotropic treatment (n = 337) had lower cortisol/CRP ratio than those not taking psychotropic agents (n = 59) (F=4.72, p = 0.03). Compared to HC, only patients on regular psychotropic agents had lower cortisol/CRP ratio (p = 0.02). Within the SZ group, lower cortisol/CRP ratio was associated with having poorer general functioning as measured by GAF (ß=-0.18, p = 0.01), and more severe negative and general symptomatology as measured by PANSS (ß=0.19, p = 0.007 and ß=0.18, p = 0.01, respectively). In SZ, lower cortisol/CRP ratio was also associated with poorer verbal memory, learning, and processing speed (ß=-0.20 p = 0.007, ß=-0.19 p = 0.01, ß=-0.25, p &gt; 0.001, respectively). No associations were observed between cortisol/CRP ratio and clinical and cognitive functioning in the BD group.</div></div><div><h3>Conclusion</h3><div>These findings may indicate HPA axis-immune dysregulation in SZ. Our study further indicates that disrupted HPA axis-immune regulation in people with SZ and BD is associated with psychotropic treatment and fat mass, highlighting the clinical importance of weight control and regular psychotropic treatment follow-ups within this group.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107272"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multiverse meta-analysis of intranasal oxytocin studies","authors":"H. Kang ,&nbsp;A. M. Sartorius ,&nbsp;E. Deilhaug ,&nbsp;K.M. Walle ,&nbsp;D.S. Quintana","doi":"10.1016/j.psyneuen.2025.107312","DOIUrl":"10.1016/j.psyneuen.2025.107312","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107312"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143547801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invited keynote: Impacts of technology on the brain","authors":"E. Telzer","doi":"10.1016/j.psyneuen.2025.107294","DOIUrl":"10.1016/j.psyneuen.2025.107294","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107294"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perception of unfamiliar caregivers during experimental sickness","authors":"L.S. Hansson ,&nbsp;A. Tognetti ,&nbsp;P. Sigurjónsson ,&nbsp;E. Brück ,&nbsp;K. Wåhlén ,&nbsp;K. Jensen ,&nbsp;M.J. Olsson ,&nbsp;R. Toll John ,&nbsp;D.B. Wilhelms ,&nbsp;M. Lekander ,&nbsp;J. Lasselin","doi":"10.1016/j.psyneuen.2025.107338","DOIUrl":"10.1016/j.psyneuen.2025.107338","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107338"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does including multiple hormones family context together clarify hormone-behavior associations? A systematic Review","authors":"K. Marceau,&nbsp;S. Lee,&nbsp;J Hu,&nbsp;P.A. Regacho,&nbsp;G.S. Canino-Quinones","doi":"10.1016/j.psyneuen.2025.107322","DOIUrl":"10.1016/j.psyneuen.2025.107322","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107322"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}