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Effect of lipid-based nutrient supplementation on children's hair cortisol in late childhood
IF 3.4 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-02-01 DOI: 10.1016/j.psyneuen.2025.107323
H Nti , P.D. Hastings , S. Adu-Afarwuah , E. Adjetey , B. Amponsah , C.D. Arnold , L.M.D. Aryee , F.B. Ayete Labi , H.J. Bentil , K.G. Dewey , A. Guyer , A. Manu , M.O. Mensah , E.L. Prado , E. Shirtcliff , X. Tan , B.M. Oaks
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引用次数: 0
The association between stress and autoimmune thyroid disease: a systematic review
IF 3.4 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-02-01 DOI: 10.1016/j.psyneuen.2025.107348
M.A.V. Bastos Jr , V.V.F. Silva , A.C.D. Salina
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引用次数: 0
HappyMums: Developing digital technology to better predict antenatal depression
IF 3.4 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-02-01 DOI: 10.1016/j.psyneuen.2025.107325
K.M.S. Priestley , R. Laijawala , R.H. Bind , K. Hazelgrove , M. Kirkpatrick , L. Rebecchini , P. Dazzan , HM. HappyMums Consortium , C.M. Pariante
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引用次数: 0
Housing insecurity and health: A preliminary study of stress and physiological dysregulation among unhoused individuals in Oregon
IF 3.4 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-02-01 DOI: 10.1016/j.psyneuen.2025.107329
A.L. Van Steenis , E.A. Shirtcliff , L.Z. DuBois , L.J. Weaver , J.J. Snodgrass
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引用次数: 0
Do pregnant women show enhanced sensitivity to emotional displays of threat?
IF 3.4 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-02-01 DOI: 10.1016/j.psyneuen.2025.107320
A.C. Hahn, L.E. Larsen, Z. Royer
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引用次数: 0
Unfavourable glucose metabolism is associated with functional somatic disorders. A cross-sectional general population-based study: The DanFunD study 不利的葡萄糖代谢与功能性躯体疾病有关。一项基于普通人群的横断面研究:DanFunD 研究。
IF 3.4 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-02-01 DOI: 10.1016/j.psyneuen.2024.107258
Thomas Meinertz Dantoft , Sine Wanda Jørgensen , Kaare Bro Wellnitz , Eva Ørnbøl , Lise Gormsen , Per Fink , Allan Linneberg , Niklas Rye Jørgensen , Marie Weinreich Petersen , Anne Ahrendt Bjerregaard , Torben Jørgensen

Objectives

Several studies have observed associations between unfavorable levels of blood glucose metabolic markers (i.e., fasting glucose, fasting insulin, glycated hemoglobin (HbA1c), and insulin resistance (HOMA-IR)) and functional somatic disorder (FSD). However, such associations have not yet been systematically analyzed in a general population-based sample using various FSD delimitations simultaneously. The aim of this study was to assess whether an unfavorable glucose metabolism is associated with FSD.

Design

Cross-sectional population-based study

Setting

Ten municipalities in the western part of greater Copenhagen area in Denmark

Participants

A total of 8183 men and women aged 18–76 years were included. Various delimitations of FSD, i.e., chronic fatigue (CF), chronic widespread pain (CWP), irritable bowel (IB), and bodily distress syndrome (BDS), were measured using validated self-administrated questionnaires. In a stratified subsample, BDS was also assessed by diagnostic interviews.

Outcome measures

Logistic regression models were estimated for each delimitation of FSD as outcome and fasting glucose, fasting insulin, HbA1c, and estimated insulin resistance. Results were adjusted for age, sex (model 1), lifestyle, and social factors (model 2) and presented as odds ratios (OR) with 95 % confidence intervals (CI).

Results

When only adjusting for sex and age, positive associations were found between all FSD delimitations and glucose, insulin, and HbA1c, except for between IB and HbA1c. Positive associations were also found between all questionnaire-based BDS groups, and men with BDS confirmed by diagnostic interviews and elevated insulin resistance. After adjusting for lifestyle and social factors, associations remained significant between both CF and glucose and HbA1c and between multi-organ BDS and glucose and HbA1c. Further, CF, single-organ BDS, multi-organ BDS, and women with overall-BDS also remained associated with increased levels of insulin resistance.

Conclusion

FSD seems to be associated with especially an increase in plasma insulin levels and increased levels of insulin resistance. Elevated levels of blood glucose and HbA1c among all FSD groups could also completely be explained by unhealthy lifestyle. Prospective studies are needed for further clarification of the clinical relevance of this observation.
研究目的多项研究发现,血糖代谢指标(即空腹血糖、空腹胰岛素、糖化血红蛋白(HbA1c)和胰岛素抵抗(HOMA-IR))的不利水平与功能性躯体障碍(FSD)之间存在关联。然而,目前还没有在普通人群样本中同时使用各种 FSD 定义对这种关联进行系统分析。本研究旨在评估不利的糖代谢是否与 FSD 相关:设计:基于人口的横断面研究:参与者:丹麦大哥本哈根地区西部的 10 个城市:共纳入 8183 名 18-76 岁的男性和女性。使用经过验证的自我管理问卷对 FSD 的各种定义进行了测量,即慢性疲劳 (CF)、慢性广泛性疼痛 (CWP)、肠易激 (IB) 和身体不适综合征 (BDS)。在分层子样本中,BDS 也通过诊断性访谈进行评估:结果测量:以 FSD 的每种定义作为结果,并对空腹血糖、空腹胰岛素、HbA1c 和估计胰岛素抵抗进行逻辑回归模型估计。结果根据年龄、性别(模型 1)、生活方式和社会因素(模型 2)进行了调整,并以几率比(OR)和 95 % 置信区间(CI)表示:结果:仅对性别和年龄进行调整时,发现所有 FSD 定义与血糖、胰岛素和 HbA1c 之间均呈正相关,但 IB 与 HbA1c 之间除外。所有基于问卷调查的 BDS 组与经诊断性访谈确认的 BDS 男性和胰岛素抵抗升高之间也存在正相关。在对生活方式和社会因素进行调整后,CF 与血糖和 HbA1c 之间以及多器官 BDS 与血糖和 HbA1c 之间的相关性仍然显著。此外,CF、单器官 BDS、多器官 BDS 和患有整体 BDS 的女性也与胰岛素抵抗水平升高有关:结论:FSD 似乎尤其与血浆胰岛素水平升高和胰岛素抵抗水平升高有关。所有 FSD 组的血糖和 HbA1c 水平升高也完全可以用不健康的生活方式来解释。要进一步阐明这一观察结果的临床意义,还需要进行前瞻性研究。
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引用次数: 0
Association of systemic inflammation and long-term dysfunction in COVID-19 patients: A prospective cohort COVID-19患者全身性炎症与长期功能障碍的关联:一项前瞻性队列研究
IF 3.4 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-02-01 DOI: 10.1016/j.psyneuen.2024.107269
Felipe Dal-Pizzol , Bruno Kluwe-Schiavon , Henrique Ritter Dal-Pizzol , Gabriele da Silveira Prestes , Diogo Dominguini , Carolina Saibro Girardi , Lucas Santos , José Cláudio Fonseca Moreira , Daniel Pens Gelain , Roger Walz , Tatiana Barichello , Cristiane Ritter
COVID-19 has significant long-term impacts, including a chronic syndrome known as long-COVID, characterized by persistent symptoms post-recovery. The inflammatory response during acute infection is hypothesized to influence long-term outcomes. This study aimed to identify inflammatory biomarkers predictive of functional outcomes one year after hospital discharge. A prospective cohort study was conducted with 213 COVID-19 patients admitted to ICUs in Southern Brazil between June and November 2020. After exclusions and follow-ups, 109 patients were evaluated for one-year post-discharge. Plasma levels of Th1 (TNF-α, INF-γ, IL-12), Th2 (IL-4, IL-5, IL-6, IL-10, IL-13), and Th17 (IL-17, IL-22) cytokines were measured. Functional outcomes in psychiatric, cognitive, general health, and health perception domains were assessed. Statistical analyses included multivariate regression, regularized partial correlation network analysis, and K-means clustering. We demonstrate that plasma levels of various cytokines, along with demographic and clinical characteristics, can predict four distinct domains of functional outcomes one year following hospital discharge due to COVID-19 and that an hyperinflammatory phenotype was associated with the occurrence of a worse in psychiatric, general health, and health perception domains. The network analysis highlighted complex interconnections among immune markers and clinical variables, elucidating their roles in long-term health. These findings support using biomarkers for patient stratification and indicate potential targets for therapeutic interventions.
COVID-19具有重大的长期影响,包括一种被称为长期covid的慢性综合征,其特征是恢复后症状持续存在。急性感染期间的炎症反应被认为会影响长期预后。本研究旨在确定炎症生物标志物,预测出院后一年的功能结局。对2020年6月至11月期间巴西南部icu收治的213名COVID-19患者进行了一项前瞻性队列研究。经排除和随访,109例患者出院后一年进行评估。测定血浆中Th1 (TNF-α、INF-γ、IL-12)、Th2 (IL-4、IL-5、IL-6、IL-10、IL-13)和Th17 (IL-17、IL-22)细胞因子水平。评估了精神、认知、一般健康和健康感知领域的功能结局。统计分析包括多元回归、正则化偏相关网络分析和K-means聚类。我们证明,血浆中各种细胞因子的水平,以及人口统计学和临床特征,可以预测因COVID-19出院一年后四个不同的功能结果领域,并且高炎症表型与精神、一般健康和健康感知领域的恶化有关。网络分析强调了免疫标记物和临床变量之间复杂的相互联系,阐明了它们在长期健康中的作用。这些发现支持使用生物标志物进行患者分层,并指出治疗干预的潜在目标。
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引用次数: 0
Role of the medial septum neurotensin receptor 1 in anxiety-like behaviors evoked by emotional stress 内隔神经紧张素受体1在情绪压力诱发的焦虑样行为中的作用。
IF 3.4 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-02-01 DOI: 10.1016/j.psyneuen.2024.107275
Leilei Chang , Yecheng He , Bin Li
Anxiety is one of the most common mental disorders. Neurotensin (NT) is a neuropeptide widely distributed in the central nervous system, involved in the pathophysiology of many neural and psychiatric disorders such as anxiety. However, the neural substrates mediating NT’s effect on the regulation of anxiety have not been fully identified. The medial septum (MS) is a crucial brain region in regulating anxiety and expresses neurotensin receptor 1 (NTS1). In the current study, we examined the role of NT/NTS1 in the MS on the anxiety-like behaviors of rats in non-stress and acute stress conditions. We reported that intra-MS infusion of NT produced remarkable anxiogenic effect in behavioral tests. The anxiogenic effect could be blocked by NTS1 antagonist SR48692 pretreatment. Microinjection of NTS1 antagonist to block endogenously released NT in the MS had no effect on anxiety-like behaviors in non-stressed rats, but significantly reduced anxiety in acute restraint stressed rats. Moreover, molecular knockdown of NTS1 in the MS ameliorated anxiety induced by acute restraint stress, also confirming the pharmacological results. Our study implicates NT and its receptors as potential targets for therapeutic interventions of psychiatric diseases, such as anxiety.
焦虑是最常见的精神障碍之一。神经紧张素(NT)是一种广泛分布于中枢神经系统的神经肽,参与许多神经和精神疾病的病理生理,如焦虑。然而,介导NT对焦虑调节作用的神经基质尚未完全确定。内侧间隔(MS)是调节焦虑和表达神经紧张素受体1 (NTS1)的关键脑区。在本研究中,我们研究了MS中NT/NTS1在非应激和急性应激条件下对大鼠焦虑样行为的作用。我们报道ms内灌注NT在行为测试中产生显著的焦虑效应。NTS1拮抗剂SR48692预处理可阻断其致焦虑作用。显微注射NTS1拮抗剂阻断MS内源性释放的NT对非应激大鼠的焦虑样行为无影响,但显著降低急性约束应激大鼠的焦虑。此外,MS中NTS1的分子敲低可以改善急性约束应激引起的焦虑,也证实了药理学结果。我们的研究暗示NT及其受体是治疗精神疾病(如焦虑)的潜在靶点。
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引用次数: 0
Sex-specific associations between loneliness and hair cortisol among older african american adults
IF 3.4 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-02-01 DOI: 10.1016/j.psyneuen.2025.107343
K.M. Knauft , K.M. Davis , L.M. Rappaport , S. Zilioli
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引用次数: 0
New methods for exploring the correspondence between cortisol and brain activity during social stress
IF 3.4 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-02-01 DOI: 10.1016/j.psyneuen.2025.107337
K. Casto , D. Cohen
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引用次数: 0
期刊
Psychoneuroendocrinology
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