Psychoneuroendocrinology最新文献

{"title":"Morning cortisol levels and quality of social interactions across the transition to school predict the development of children’s anxious and depressive symptoms in first grade","authors":"Maggy Leblond ,&nbsp;Sophie Parent ,&nbsp;Natalie Castellanos-Ryan ,&nbsp;Sonia J. Lupien ,&nbsp;Catherine M. Herba ,&nbsp;William D. Fraser ,&nbsp;Jean R. Séguin","doi":"10.1016/j.psyneuen.2025.107721","DOIUrl":"10.1016/j.psyneuen.2025.107721","url":null,"abstract":"<div><div>Previous studies spanning the transition from preschool to school (kindergarten) revealed individual differences in children’s stress response, measured by cortisol concentrations. However, whether these represented adaptive cortisol concentration patterns or a risk factor for maladaptation remained unclear because very few studies examined functional correlates of cortisol changes, such as anxious or depressive symptoms. Furthermore, prior research has suggested that social interactions may play a significant role in this association since sensitive stress responses patterns might interact with unsupportive interactions to predict the development of mental health symptoms. For the current study, the pattern of morning cortisol concentration in children was described over 6 time-points before, during and after kindergarten entry. The first objective was to examine the associations between this pattern and the development of anxious or depressive symptoms 18 months later (first grade). The second objective was to examine whether children’s quality of social interactions (i.e., family relational health or peer problems) interacted with these same patterns to predict anxious and depressive symptoms. For this longitudinal study, children and their parents (N = 379) were recruited from the 3D pregnancy study and followed from preschool to first grade. Piecewise latent growth curve models showed that while morning cortisol concentrations increased at a similar rate for all children over the first two weeks of school, children differed from one another in their levels at school entry. During the post-entry period, morning cortisol concentrations showed a U-shaped curve: a decrease during the first two months followed by an increase for the next three to five months. Main and moderation effects suggest that a hypoactivation of the stress response system (i.e., low cortisol levels at school entry or steeper post-entry decrease) during the school transition may be a risk factor for maladaptation in children as it was associated with later increasing anxious and depressive symptoms, especially under specific social environmental conditions. Children exhibiting such hypoactive cortisol patterns appear to be more vulnerable to lower-quality social environment, whether with family or peers, supporting the diathesis-stress model. Results also highlight the potentially protective function of high-quality social interactions in the development of anxious and depressive symptoms for those with hypoactive stress response system.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"185 ","pages":"Article 107721"},"PeriodicalIF":3.6,"publicationDate":"2025-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145788604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The active monitoring of oxytocin research evidence (AMORE) platform","authors":"Ingebjørg A. Iversen ,&nbsp;Kaat Alaerts ,&nbsp;Marian Bakermans-Kranenburg ,&nbsp;Benjamin Becker ,&nbsp;Robert James Blair ,&nbsp;Jennifer A. Bartz ,&nbsp;Jessica J. Connelly ,&nbsp;Beate Ditzen ,&nbsp;Natalie C. Ebner ,&nbsp;Heemin Kang ,&nbsp;Elizabeth A. Lawson ,&nbsp;Nicole Nadine Lønfeldt ,&nbsp;Matthijs Moerkerke ,&nbsp;Christian Montag ,&nbsp;Anna-Rosa Cecilie Mora-Jensen ,&nbsp;Marilyn Horta ,&nbsp;Leehe Peled-Avron ,&nbsp;Tanya L. Procyshyn ,&nbsp;Alina I. Sartorius ,&nbsp;Dirk Scheele ,&nbsp;Daniel S. Quintana","doi":"10.1016/j.psyneuen.2025.107713","DOIUrl":"10.1016/j.psyneuen.2025.107713","url":null,"abstract":"<div><div>Oxytocin, an evolutionarily conserved neuropeptide, plays a crucial role in various physiological and behavioural processes, offering potential therapeutic benefits for several psychiatric and neurodevelopmental conditions. Despite its promise, oxytocin research has been marked by inconsistent results concerning its therapeutic applications and underlying mechanisms. Performing a systematic review and meta-analysis is a popular approach to shed light on mixed findings in a body of literature; however, they can become quickly outdated as new evidence becomes available. Given these challenges, research on the links between oxytocin and biobehavioural outcomes is ideally positioned for the adoption of ‘living’ meta-analyses, which allow for the continuous integration of new data and updated conclusions. Here we introduce the Active Monitoring of Oxytocin Research Evidence (AMORE) platform (<span><span>https://amore-project.org</span><svg><path></path></svg></span>), which is a hub that aggregates articles and materials associated with living meta-analyses for biobehavioural oxytocin research in humans. Developed through consensus among 24 expert researchers, a standardized framework was established that either requires or recommends practices ensuring transparency and rigor in living meta-analyses featured on the AMORE platform. Overall, AMORE has been designed to advance human oxytocin biobehavioural research by the timely integration of emerging evidence through transparent living meta-analyses. To date, two living meta-analysis projects at different stages of publication are hosted on AMORE, demonstrating the platform’s practical application.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"185 ","pages":"Article 107713"},"PeriodicalIF":3.6,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145739283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of a stress reactivity assessment protocol for children aged 4–5 years: Exploring the influence of sex, emotional responses, and crying","authors":"Miguel Ángel Baos-González ,&nbsp;Carolina Mariño-Narváez ,&nbsp;Javier De Echarri-Lorente ,&nbsp;Ahmed F. Fasfous ,&nbsp;Raquel González-Pérez ,&nbsp;María Isabel Peralta-Ramírez","doi":"10.1016/j.psyneuen.2025.107720","DOIUrl":"10.1016/j.psyneuen.2025.107720","url":null,"abstract":"<div><h3>Background</h3><div>Early childhood is an important period for the development of stress regulation systems, yet validated protocols to assess stress reactivity in preschoolers remain scarce. The current study aimed to validate a stress reactivity laboratory protocol based on the matching task in a Spanish sample of 4–5-year-old children, while exploring the influence of sex, emotional responses, and potential confounding variables.</div></div><div><h3>Methods</h3><div>Fifty-eight preschoolers participated in the Stress Reactivity Task for Preschoolers (SRTP), which included six salivary samples for the measurement of cortisol (as a marker of hypothalamic-pituitary-adrenal [HPA] axis activity) and alpha-amylase (as a marker of sympathetic nervous system [SNS] activity). Behavioral and emotional responses were also coded. Statistical analyses included repeated-measures GLMs, paired t-tests, and correlation analyses to evaluate biomarker patterns and confounders.</div></div><div><h3>Results</h3><div>The SRTP effectively elicited a stress response: 77.6 % of children were classified as alpha-amylase responders, and 64.9 % as cortisol responders. Alpha-amylase levels increased sharply post-task and gradually returned to baseline within 40 min. In contrast, cortisol levels peaked later and remained elevated for a longer period. No correlation was found between the two biomarkers. Emotional and observational data supported the presence of stress, with significant increases in anger, sadness, and nervousness during the task. Notably, girls exhibited faster cortisol reactivity and greater sadness than boys. Among all examined variables, crying emerged as the most influential confounder, being strongly associated with heightened cortisol reactivity.</div></div><div><h3>Conclusions</h3><div>The SRTP is a valid and sensitive protocol for assessing stress reactivity in preschool-aged children. It enables simultaneous assessment of SNS and HPA axis activity and captures meaningful interindividual differences. These findings contribute to a more nuanced understanding of early stress physiology and may inform future longitudinal studies and preventive interventions.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"184 ","pages":"Article 107720"},"PeriodicalIF":3.6,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145748734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discrimination and allostatic load in black middle-aged and older adults: A systematic review and meta-analysis","authors":"Alaa Harb ,&nbsp;Juliana Souza-Talarico ,&nbsp;Peter B. Abad ,&nbsp;Karen Lawrence ,&nbsp;Jihye Lee ,&nbsp;Ana W. Capuano ,&nbsp;Lisa L. Barnes ,&nbsp;Jennifer Deberg","doi":"10.1016/j.psyneuen.2025.107714","DOIUrl":"10.1016/j.psyneuen.2025.107714","url":null,"abstract":"<div><h3>Background</h3><div>Perceived discrimination has been associated with elevated allostatic load (AL), but findings among Black middle-aged and older adults are inconsistent. A focused synthesis is lacking, limiting understanding of how discrimination becomes biologically embedded. This systematic review and meta-analysis aim to clarify the discrimination and AL relationship in Black individuals during aging and highlight key methodological and contextual factors.</div></div><div><h3>Methods</h3><div>A systematic search of seven databases following PRISMA guidelines included studies on discrimination and AL in Black adults aged 40 and older. AL measures were multisystem indexes of stress-related biomarkers. Study quality was assessed using ROBINS-E, and a random-effects meta-analysis estimated the overall effect size.</div></div><div><h3>Results</h3><div>Five studies met the inclusion criteria. Four reported significant associations between discrimination, particularly everyday or adolescent exposure, and higher AL. One study found a negative association moderated by coping mechanisms, while another revealed a significant interaction with hopefulness. Meta-analysis of four studies showed a small, non-significant pooled effect (Hedges’s g = 0.132; 95 % CI: −0.338–0.602; p = 0.582) with high heterogeneity (I² = 94.24 %). Stronger associations appeared in studies using broader biomarker panels and more recent discrimination measures.</div></div><div><h3>Conclusions</h3><div>This study highlights an inconsistent and heterogeneous relationship between discrimination and AL in Black middle-aged and older adults. While evidence suggests a general link, findings remain mixed due to methodological variability. The meta-analysis found no significant pooled effect, reflecting limited and diverse studies. Future research should prioritize longitudinal designs, standardized measures, and consideration of coping and resilience factors.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"184 ","pages":"Article 107714"},"PeriodicalIF":3.6,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145725714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Androstadienone reduces women’s mate-choice copying: The moderating role of intrasexual competition","authors":"Ludan Liu ,&nbsp;Lijun Zheng","doi":"10.1016/j.psyneuen.2025.107717","DOIUrl":"10.1016/j.psyneuen.2025.107717","url":null,"abstract":"<div><div>Androstadienone (AND), a putative human chemosignal, has been shown to influence women’s mate preferences, but whether it also shapes mate-choice strategies remains unclear. The present research tested the hypothesis that AND reduces women’s mate-choice copying, and that this inhibitory effect is moderated by intrasexual competition. Using a double-blind design, participants attended two sessions on consecutive days, inhaling either AND or a placebo (order randomized), and then completed a mate-choice copying task. In Study 1 (<em>N</em> = 54), AND reduced mate-choice copying among women low in intrasexual competition, whereas women high in intrasexual competition showed little copying under both AND and placebo conditions. Study 2 (<em>N</em> = 50) experimentally primed intrasexual competition and replicated these findings: when competition was primed, women displayed no mate-choice copying in either condition, whereas under non-competitive conditions AND suppressed copying. Across both studies, women exposed to AND reported a significantly lower perception of intimacy in romantic pairs compared to those in the placebo group. These findings provide the first evidence that AND regulates women’s mate-choice copying under conditions of low intrasexual competition.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"184 ","pages":"Article 107717"},"PeriodicalIF":3.6,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145691040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of circulating immune cell phenotypes and peripheral inflammatory biomarkers with depressive symptoms in the Framingham Heart Study","authors":"Sandhya Iyer ,&nbsp;Yumeng Cao ,&nbsp;Ryan Liebegott ,&nbsp;Jiachen Chen ,&nbsp;Ahmed Ragab ,&nbsp;Margaret F. Doyle ,&nbsp;Kathryn L. Lunetta ,&nbsp;Joanne M. Murabito","doi":"10.1016/j.psyneuen.2025.107716","DOIUrl":"10.1016/j.psyneuen.2025.107716","url":null,"abstract":"<div><h3>Background</h3><div>Depression is a common mental health disorder with substantial impact on older adults. Immune dysfunction has been studied as a mechanism for depressive symptoms, providing the opportunity for new targeted treatment approaches.</div></div><div><h3>Methods</h3><div>This study investigated the associations between immune cell phenotypes, determined by flow cytometry, and peripheral inflammatory biomarkers, measured using the OLINK Inflammation panel, with Center for Epidemiologic Studies Depression Scale (CES-D) scores, indicative of depressive symptoms, in the Framingham Heart Study Offspring Cohort. Regression models were used with proteins or immune cells as predictors and CES-D scores as the outcome, adjusting for age, sex, BMI, smoking status, CVD, depression medication use, NSAID use, and cytomegalovirus (CMV) status (immune cells only). We used Bonferroni adjusted p &lt; 0.005 to declare significance. Effect estimates (beta) are reported in standard deviation units.</div></div><div><h3>Results</h3><div>Participants (n = 831) had a mean age 61, were 52 % female, and had a mean CES-D score 5 (SD=7) with 8 % (n = 67) having a CES-D score &gt; /= 16. Our results suggested a positive association between FGF-19 and CES-D score (beta=0.11, p = 0.004), as well as a suggestive negative trend between the CD8 +IL17 + :CD8 +CD25 +FoxP3 + ratio (CD8Tc17/CD8 +Tregs) and CES-D score (beta=-0.1, p = 0.03). In addition, we observed a positive suggestive trend between IL-17C and depressive symptoms (CES-D &gt;/= 16) (beta=0.35 p = 0.009), that strengthened with higher levels of symptoms (p &lt; 0.005).</div></div><div><h3>Conclusion</h3><div>The positive association between FGF-19 and depressive symptoms may suggest the contribution of metabolic and cognitive dysfunction to the pathophysiology of depression. The link between higher IL-17C levels and high CES-D score increased in strength as the cutoff point for a high CES-D score was increased, suggesting a link between IL-17C and more severe depressive symptoms. This study helps to expand our understanding of the role of inflammation in the pathophysiology of depression.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"184 ","pages":"Article 107716"},"PeriodicalIF":3.6,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145688001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linking hair cortisol and life stress: The role of stress reactivity and habituation","authors":"Jari Planert ,&nbsp;Tobias Stalder ,&nbsp;Katharina Huthsteiner ,&nbsp;George M. Slavich ,&nbsp;Tim Klucken ,&nbsp;Johannes B. Finke","doi":"10.1016/j.psyneuen.2025.107715","DOIUrl":"10.1016/j.psyneuen.2025.107715","url":null,"abstract":"<div><h3>Background</h3><div>Hair cortisol concentration (HCC) has emerged as a biomarker for long-term cortisol secretion, yet evidence linking HCC to self-reported life stress remains inconsistent. Although individual differences in acute stress reactivity as well as habituation may moderate this association, no research has examined how these processes interact to modulate the HCC-stress link. Moreover, most studies have relied on assessments of recent stressor exposure only, with limited attention to lifetime stressor exposure.</div></div><div><h3>Method</h3><div>A final sample of 72 healthy individuals (53 women) who provided hair samples and underwent the Trier Social Stress Test three times over consecutive weeks, during which changes in salivary cortisol, cardiovascular parameters, and self-reported stress were assessed. The Stress and Adversity Inventory was administered to assess lifetime stressor exposure.</div></div><div><h3>Results</h3><div>As hypothesized, preregistered analyses showed that greater lifetime stressor exposure and acute cortisol reactivity were both associated with elevated HCC. No association was found between HCC and stress habituation, and no moderation effects on the relation between HCC and lifetime stressor exposure were observed for reactivity or habituation. Exploratory analyses revealed a consistent link between early-life stressor exposure and HCC, whereas a positive association with adulthood stressors was evident only for individuals with less cortisol reactivity.</div></div><div><h3>Conclusions</h3><div>The results suggest that HCC reflects not only lifetime stressor exposure but is also influenced by individual differences in cortisol reactivity, highlighting its role as an integrative, yet complex biomarker of chronic stress. In contrast, the lack of an association with habituation indicates limited sensitivity to dynamic adaptation processes occurring over weeks.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"184 ","pages":"Article 107715"},"PeriodicalIF":3.6,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145715493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypothalamic-pituitary-adrenal (HPA) axis stress response to a laboratory-based 10 % CO2 challenge in healthy adults","authors":"Harrison Dickens ,&nbsp;L. Riley Gournay-Berman ,&nbsp;Morgan Hill ,&nbsp;Mikayla D.M. Joslin ,&nbsp;Jamie Walker ,&nbsp;Anastasia Makhanova ,&nbsp;Ellen Leen-Feldner ,&nbsp;Ivan Vargas","doi":"10.1016/j.psyneuen.2025.107712","DOIUrl":"10.1016/j.psyneuen.2025.107712","url":null,"abstract":"<div><h3>Background</h3><div>Acute stress reactivity has been implicated in a wide range of physical and psychological disorders. Most literature has focused on laboratory paradigms that elicit neuroendocrine responses via socially evaluative stress. While shown to be effective at eliciting stress responses, these socially evaluative paradigms may only tap into a narrow range of stressors. Carbon dioxide (CO₂) inhalation challenges have been shown to reliably elicit panic-relevant symptoms in healthy populations but evidence on the ability to elicit a neuroendocrine response is limited.</div></div><div><h3>Methods</h3><div>The current secondary analysis sought to examine the magnitude of neuroendocrine, sympathetic, and emotional response to a 5-minute, 10 % CO₂-enriched air inhalation task in healthy volunteers. Seventy-five healthy adults (<em>M</em>_<em>age</em> <em>:</em> 27.2, 53.3 % female) completed the laboratory procedure.</div></div><div><h3>Results</h3><div>Results from mixed effects growth curve models found a significant linear (<em>b</em> = 0.006, <em>df</em> = 367, <em>p</em> &lt; 0.001) and quadratic effect (<em>b</em> = −0.0001, <em>df</em> = 293, <em>p</em> &lt; 0.001) of the challenge on salivary cortisol. The majority of the sample (57.3 %) experienced at least a 50 % increase in salivary cortisol from baseline. Women displayed a more blunted cortisol response than men (<em>b</em> = −0.00007, <em>df</em> = 293, <em>p</em> &lt; 0.001). Hormonal contraceptive users, relative to naturally cycling women, also had a more blunted reactivity slope. Both heart rate and perceived fear also increased significantly in response to the task.</div></div><div><h3>Conclusions</h3><div>Findings from the current study suggest that the CO₂ protocol employed in the current study can elicit meaningful neuroendocrine, sympathetic, and emotional responses.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"184 ","pages":"Article 107712"},"PeriodicalIF":3.6,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145725766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intersectional stigma, health behaviors, and allostatic load among sexual and gender diverse people","authors":"Nevena Chuntova ,&nbsp;Inès Ait Abdelmalek ,&nbsp;Karine Lavallée-Rodrigue ,&nbsp;Emma-Rose Thériault ,&nbsp;Ryan Hogan ,&nbsp;Ziad Guenoun ,&nbsp;Jasmine Boulette ,&nbsp;Ahmed Jérome Romain ,&nbsp;L. Zachary DuBois ,&nbsp;Robert-Paul Juster","doi":"10.1016/j.psyneuen.2025.107708","DOIUrl":"10.1016/j.psyneuen.2025.107708","url":null,"abstract":"<div><div>Sexual and gender diverse (SGD) people face significant health disparities linked to chronic stigma exposure. Yet, the biological mechanisms underlying these inequities remain unexplored. This project examines how lifetime intersectional discrimination influences allostatic load (AL) —the cumulative biological 'wear and tear' of chronic stress—and explores the role of health behaviors (smoking, alcohol use, drug use, sleep quality and physical activity) as potential mediators in this pathway. Our team recruited 357 adults separated into 7 subgroups stratified by gender identity and sexual orientation. Blood samples and biometrics were collected from each participant and analysed to create a composite AL index incorporating 16 biomarkers across multiple physiological systems. Psychosocial variables including intersectional discrimination experiences and health behaviors were derived from validated questionnaires. Results show that intersectional discrimination experiences were positively associated with AL after controlling for age, indicating that both major discriminatory events and cumulative daily experiences independently contribute to physiological dysregulation through enacted stigma and discrimination exposure. Additionally, both gender identity and sexual orientation relate to differential AL patterns, with masculine-spectrum people (cisgender and transgender men) and sexual minority men (bisexual and gay men) showing the highest AL levels. Contrary to our hypothesis, health behaviors did not mediate the relationship between discrimination and AL, suggesting that discrimination may exert direct biological effects through stress response systems without requiring negative behavioral pathways. These findings provide further support for recognition of the impacts of structural and social determinants of health among SGD communities and the need for policy changes that protect against structural inequities.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"184 ","pages":"Article 107708"},"PeriodicalIF":3.6,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145669623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroendocrine profiles in relation to female callous-unemotional traits and distress facilitation","authors":"Victoria Auricht ,&nbsp;Natalie Goulter ,&nbsp;Eva R. Kimonis","doi":"10.1016/j.psyneuen.2025.107710","DOIUrl":"10.1016/j.psyneuen.2025.107710","url":null,"abstract":"<div><div>Emerging evidence supports that primary and secondary callous-unemotional (CU) variants show distinct physiological correlates, though prior research has exclusively distinguished CU variants based on psychosocial measures, rather than physiological indices, and focused on male samples. This study aimed to determine whether identified neuroendocrine (i.e., cortisol, dehydroepiandrosterone [DHEA], and testosterone) profiles mapped onto theoretically relevant psychosocial constructs consistent with CU variants, and whether profiles differed in emotional processing. Salivary samples from undergraduate women (<em>M</em>_<em>age</em> = 19.02 years; <em>SD</em> = 1.50) oversampled for high psychopathic/CU traits (<em>N</em> = 101) were assayed for basal cortisol, DHEA, and testosterone. Participants completed self-report measures of CU traits, maltreatment history, anxiety, and depression, and a dot-probe task assessing facilitation to emotional distress. Latent profile analysis revealed a ‘hypoactive’ profile with low cortisol, DHEA, and testosterone, and a ‘hyperactive’ profile with high cortisol, DHEA, and testosterone. Profiles partially aligned with psychosocial measures used to validate theoretical conceptualizations of CU variants, and the hyperactive profile showed greater facilitation to emotional distress relative to the hypoactive profile. Findings add to a limited literature on female CU traits in relation to neuroendocrine functioning and emotional processing. Our findings also provide preliminary evidence of possible congruency between physiological and psychosocial measures underlying the identification of CU variants.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"184 ","pages":"Article 107710"},"PeriodicalIF":3.6,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145668466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}