Psychoneuroendocrinology最新文献

{"title":"Demonstrating the potential of untargeted hair proteomics for personalized biomarkers in stress-associated disorders","authors":"Maurizio Sicorello ,&nbsp;Jeanne-Carla Sprenger ,&nbsp;Lisa M Störkel ,&nbsp;Bettina Sarg ,&nbsp;Leopold Kremser ,&nbsp;Christian Schmahl ,&nbsp;Inga Niedtfeld ,&nbsp;Alexander Karabatsiakis","doi":"10.1016/j.psyneuen.2025.107684","DOIUrl":"10.1016/j.psyneuen.2025.107684","url":null,"abstract":"<div><div>Biomarker research in psychopathology increasingly employs high-dimensional <em>Omics</em> approaches. Yet, proteomics based on human hair remain largely unexplored, despite its potential to efficiently capture stable biological signals accumulated over weeks to months. This study leveraged machine learning to investigate the potential of the hair proteome—all detectable peptides and proteins—as a biomarker source for stress-associated psychopathology. We analyzed protein profiles from hair segments of women with non-suicidal self-injury disorder and healthy controls (<em>N</em> = 68). Of 1114 identified proteins, 611 were sufficiently abundant for analyses. Partial Least Squares Discriminant Analysis achieved stable 84.4 % cross-validated accuracy for classification of clinical groups (p &lt; .001), outperforming models based on data-derived clusters (60 %), stress-related proteins (73 %), and simulated hair cortisol from meta-analytic effect sizes (53–59 %). Predicted class probabilities strongly correlated with clinical symptoms and well-being (r &gt; .60). Key predictive proteins were linked to pain perception, oxidative stress, and cholesterol homeostasis. Approximately 15 % of proteins differed significantly between groups, with the strongest candidates related to ribosomal function—an emerging target in depression. These findings establish hair proteomics as a promising, non-invasive biomarker source for psychiatric research with potential clinical applications in risk assessment and personalized interventions.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"184 ","pages":"Article 107684"},"PeriodicalIF":3.6,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145577724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Everyday discrimination frequency, intersectional attributions, and C-reactive Protein for Black midlife women who experience discrimination","authors":"Vanessa V. Volpe ,&nbsp;Sasha C. Mejía-Bradford ,&nbsp;Abbey N. Collins","doi":"10.1016/j.psyneuen.2025.107680","DOIUrl":"10.1016/j.psyneuen.2025.107680","url":null,"abstract":"<div><div>Discrimination is a chronic psychosocial stressor that elevates the inflammation response. If chronically activated, this elevation may contribute to health risks such as cardiovascular disease and obesity among Black women, who disproportionately experience discrimination at the intersection of racism and sexism. We used cross-sectional data from the Study of Women’s Health Across the Nation to examine how both discrimination frequency and discrimination attributions (single gender, single race, or the intersection of gender and race) relate to levels of the inflammatory biomarker C-reactive protein (CRP) among Black midlife women (n = 209, <em>M</em>_<em>age</em> = 52.67). Midlife represents a critical period for the emergence of cardiometabolic disease, making it an important developmental stage for understanding how discrimination shapes inflammation and health. Participants reported experiencing relatively frequent discrimination during one visit of the study. CRP levels were assayed from blood samples. Using the Detroit Area Study Everyday Discrimination Scale, women reported the frequency with which they experienced discrimination and selected all attributions for that experience from a list of potential social identity statuses. From these responses, we derived single-race, single-gender, and intersectional race-and-gender attribution categories. Linear regression analyses revealed that discrimination frequency was not significantly associated with CRP (<em>p</em> = .424). There was no difference in CRP levels between those who made a single race attribution and those who made an intersectional attribution. Black women who made a single attribution to gender had higher CRP levels compared to those who made an intersectional attribution (<em>β</em> =.14, 95 % CI [.21, 7.01], <em>p</em> = .038). Attributions of discrimination to gender but not, at least in some part, to race may increase health risks for Black midlife women if inflammation is chronically elevated. More research on the content of intersectional attributions of discrimination, above and beyond the frequency of exposure, is needed.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"183 ","pages":"Article 107680"},"PeriodicalIF":3.6,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145467798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortisol, stress, and cognition in military subpopulations: A systematic review and meta-analysis","authors":"Katherine E. Crabb ,&nbsp;Madeleine Clay ,&nbsp;Uyen Pham ,&nbsp;Lisa K. Chinn ,&nbsp;Elena L. Grigorenko","doi":"10.1016/j.psyneuen.2025.107679","DOIUrl":"10.1016/j.psyneuen.2025.107679","url":null,"abstract":"<div><div>This systematic review and meta-analysis investigated the role of cortisol in the relationship between acute stress and cognitive performance in military subpopulations. Given the high operational demands placed on military personnel, understanding the neurobiological mechanisms that support or impair cognition under stress may provide critical insight into managing the effects of this relationship. A comprehensive literature search identified 18 studies (n = 572) assessing cortisol levels and cognitive performance in military personnel exposed to acute stressors. Cortisol was not a consistent moderator of stress-related cognitive changes in military personnel, highlighting the complexity of neuroendocrine influences on cognition in general, and in this subpopulation in particular. Findings suggest that cognitive domain and methodological characteristics meaningfully shape outcomes.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"183 ","pages":"Article 107679"},"PeriodicalIF":3.6,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145513690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The inner dynamics of positive human-animal interactions: Investigating the roles of oxytocin, opioids, dopamine, serotonin and the proteome","authors":"Oceane Schmitt ,&nbsp;Suzanne Truong ,&nbsp;Winfried Otten ,&nbsp;Hana Volkmann ,&nbsp;Julia Greiner ,&nbsp;Marlies Dolezal ,&nbsp;Karin Hummel ,&nbsp;Attilio Rocchi ,&nbsp;Jean-Loup Rault","doi":"10.1016/j.psyneuen.2025.107678","DOIUrl":"10.1016/j.psyneuen.2025.107678","url":null,"abstract":"<div><div>Research on the neuroendocrine basis of positive interactions has predominantly focused on oxytocin (OT), although dopamine (DA) and opioids also play crucial roles. Furthermore, these neurotransmitters are known to interact with each other but have seldom been studied concurrently. In this study, we quantified longitudinal changes in these neurotransmitters using a within-subject, 2 × 2 factorial design by varying human familiarity (familiar versus unfamiliar) and contact type (positive contacts versus ignoring) for 10 min human-pig interaction sessions. We obtained cerebrospinal fluid samples from 10 pigs through a spinal catheter 65 and 5 min before the test and at 10, 30, 60, 120 and 240 min after the start of the test. Samples at various timepoints were analysed for OT, DA metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA), β-endorphin opioids concentrations, and using proteomics to explore novel protein candidates. Additionally, the duration and frequency of physical contacts initiated by the pig toward the human were coded from videos. The test condition (human familiarity × contact type) had a significant effect on the concentration of β-endorphin (F_1118.59 = 4.45; P = 0.04) and 5-HIAA (F_1,73.47 = 5.02; P = 0.03), and tended to affect the concentration of OT (F_{1, 119.8} = 3.19; P = 0.08) and DOPAC (F_1,70.57 = 3.31; P = 0.07), but pairwise comparisons were not significant or showed complex changes. Specifically, OT was highest when the unfamiliar humans ignored the pig compared to when they delivered positive contacts (t_70.6 = 3.31; P = 0.008), and β-endorphin tended to be higher after interacting with the familiar human compared to the unfamiliar humans (60 min post-test; t_37.9 = 3.3; P = 0.055). There were only minor differences in the pigs’ behaviour, suggesting that pigs seemed to perceive all test conditions as positive. Nevertheless, β-endorphin and OT appear to relate to different aspects of the interactions, possibly familiarity vs. novelty respectively.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"183 ","pages":"Article 107678"},"PeriodicalIF":3.6,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145459595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consummatory deficits in close social reward predict inflammation-induced depressed mood","authors":"Chloe C. Boyle ,&nbsp;Danny Rahal ,&nbsp;J. Meinert ,&nbsp;V. Ko ,&nbsp;R. Olmstead ,&nbsp;Naomi I. Eisenberger ,&nbsp;Michael R. Irwin","doi":"10.1016/j.psyneuen.2025.107673","DOIUrl":"10.1016/j.psyneuen.2025.107673","url":null,"abstract":"<div><h3>Background</h3><div>Inflammation is implicated in the etiology of depression, but not all individuals develop mood symptoms when exposed to inflammatory states. Identifying psychological predictors of this vulnerability is critical for advancing mechanistic models of depression. Deficits in global reward processing predict risk for depression, but reward processing involves both temporal dimensions (e.g., anticipatory vs. consummatory pleasure) and experiential domains (e.g., social vs. non-social). It remains unknown whether specific aspects of reward experience predict greater affective sensitivity to inflammation. This study examined whether lower in-the-moment and anticipated enjoyment across multiple reward domains in daily life predicted greater increases in depressed mood following an experimental inflammatory challenge.</div></div><div><h3>Methods</h3><div>Secondary analyses were completed on data from healthy female adults (<em>n</em> = 40; age 25–44) who were enrolled in a double-blind, randomized, placebo-controlled trial in which participants were randomly assigned to receive either low-dose endotoxin (<em>n</em> = 18) or placebo (<em>n</em> = 22) and reported on depressed mood pre- and post-infusion. Prior to the challenge, participants completed a 7-day ecological momentary assessment (EMA) protocol, rating anticipated and in-the-moment enjoyment five times daily across three reward domains: close social interactions, general social interactions, and non-social experiences.</div></div><div><h3>Results</h3><div>Linear mixed models were used to generate person-level estimates of EMA reward ratings. Endotoxin induced increases in depressed mood (<em>p</em> = .001), and this effect was moderated by enjoyment of close social interactions; lower enjoyment was associated with greater depressed mood responses to endotoxin (<em>p</em> = .004). Results were similar when adjusting for baseline levels of depressive symptoms. Enjoyment of general social interactions and non-social rewards, as well as anticipated enjoyment across all reward domains, did not moderate depressed mood responses to the inflammatory challenge (<em>p</em>’s &gt; .05).</div></div><div><h3>Discussion</h3><div>These preliminary results suggest that reduced enjoyment of close social interactions uniquely predicts vulnerability to inflammation-induced depressed mood in female adults. Interventions targeting close social relationships and strategies for savoring social experiences may play a critical role in preventing inflammation-related depression.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"183 ","pages":"Article 107673"},"PeriodicalIF":3.6,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145452824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-dependent behavioral responses and phenotypic traits of Pcsk9 knockout mice in anxiety- and depression-like paradigms","authors":"Sofia Nasini ,&nbsp;Benedetta Barzon ,&nbsp;Sara Tidei ,&nbsp;Ilaria Rossi ,&nbsp;Maria Giovanna Lupo ,&nbsp;Nicola Ferri ,&nbsp;Stefano Comai","doi":"10.1016/j.psyneuen.2025.107660","DOIUrl":"10.1016/j.psyneuen.2025.107660","url":null,"abstract":"<div><div>Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) regulates plasma LDL cholesterol by promoting the degradation of LDL receptors. Beyond lipid metabolism, PCSK9 has been implicated in neuropsychiatric conditions, including depression and anxiety, potentially through mechanisms involving inflammation, insulin resistance, and hormonal regulation. This preclinical study investigated the effects of Pcsk9 deficiency on anxiety- and depression-like behaviors in male and female C57BL/6 mice, with additional analysis of corticosterone levels and the estrous cycle in females, taking advantage of the Pcsk9 knock-out (Pcsk9 KO) mouse model. Regardless of sex, Pcsk9 KO mice showed increased anxiety-like behavior, with reduced time and fewer entries into the open arms of the Elevated Plus Maze (p &lt; 0.0001), and less time in the light compartment of the Light-Dark Box Test (p &lt; 0.001). Exploratory behavior was greater in females than in males across genotypes. In the Open Field Test, Pcsk9 KO females traveled shorter distances and at lower speeds than WT females (p &lt; 0.01), while within Pcsk9 KO mice only, males were more active than females (p &lt; 0.05). In both sexes, Pcsk9 KO mice showed increased immobility in the Tail Suspension and Forced Swim Tests (p &lt; 0.05), and elevated grooming in the Splash Test (p &lt; 0.05). Estrous cycle analysis revealed that Pcsk9 KO females spent more time in estrus (p &lt; 0.0001) and less (p = 0.0083) in diestrus than WT females, suggesting altered hormonal regulation. However, corticosterone levels did not significantly differ between groups. These findings indicate that, in a murine model of Pcsk9 deficiency, this loss may associate with sex-dependent emotional dysregulation, thus supporting further preclinical and clinical investigations into its neuropychiatric relevance.<span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (281KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"183 ","pages":"Article 107660"},"PeriodicalIF":3.6,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145418926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between childhood autistic traits and diurnal cortisol activity in adolescence","authors":"Ellie Roberts ,&nbsp;Marta Francesconi ,&nbsp;Eirini Flouri","doi":"10.1016/j.psyneuen.2025.107672","DOIUrl":"10.1016/j.psyneuen.2025.107672","url":null,"abstract":"<div><h3>Background</h3><div>Autistic adolescents experience higher levels of stress compared to non-autistic adolescents. Chronic stress is associated with dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, which can be measured by cortisol levels. Previous studies investigating cortisol activity in autistic adolescents are predominantly cross-sectional, have small sample sizes, exclude females, and include those with a clinical diagnosis of autism. The currently study sought to prospectively examine whether the severity and persistence of autistic traits in childhood is associated with cortisol activity in adolescence in a population-representative cohort.</div></div><div><h3>Methods</h3><div>Data from 915 participants from the Avon Longitudinal Study of Parents and Children (ALSPAC) were used. Bivariate correlations were calculated between autistic traits (using the Social Communication Disorders Checklist) at ages 8, 11 and 14 years and four cortisol activity indices at age 15 years (diurnal cortisol slope, cortisol awakening response (CAR), total morning cortisol, and daily total cortisol output). Regression analyses investigated the effect of autistic traits on cortisol activity, before and after adjustment for confounders.</div></div><div><h3>Results</h3><div>Being likely autistic (i.e., demonstrating severe and persistent autistic traits across ages 8–14 years) was associated with increased CAR, even after adjustment for confounders. No associations were observed between autistic traits and diurnal cortisol slope, total morning cortisol, or total daily cortisol output.</div></div><div><h3>Conclusion</h3><div>The observation that autistic traits are associated with CAR, but not other cortisol activity indicators, suggests this may not reflect a generalised HPA axis dysfunction in autistic youth, but a heightened situational response during periods of transition and increased anticipatory stress.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"183 ","pages":"Article 107672"},"PeriodicalIF":3.6,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145418927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fetal Dehydroepiandrosterone from Hair Samples at Birth Predicts Language Development","authors":"Michaela Reimann-Ayiköz ,&nbsp;Jasmin Preiß ,&nbsp;Eva Reisenberger ,&nbsp;Cristina Florea ,&nbsp;Monika Angerer ,&nbsp;Manuel Schabus ,&nbsp;Dietmar Roehm ,&nbsp;Gesa Schaadt ,&nbsp;Claudia Männel","doi":"10.1016/j.psyneuen.2025.107663","DOIUrl":"10.1016/j.psyneuen.2025.107663","url":null,"abstract":"<div><h3>Objective</h3><div>Sex hormones testosterone and estradiol have been related to children’s language development. Expanding the focus on dehydroepiandrosterone (DHEA), which has not yet been considered as a biological marker of language ability, may provide novel insights, as emerging evidence suggests that fetal DHEA plays a critical role in the organization of the neonatal brain, potentially shaping later language development. The present study investigated whether fetal DHEA, compared to fetal testosterone, is associated with infant language development.</div></div><div><h3>Design and methods</h3><div>DHEA and testosterone concentrations were measured in newborn hair strands (n = 63) collected two weeks after birth, capturing fetal long-term hormone secretions during the third trimester of pregnancy. At six months of age, children's language abilities were assessed using the German version of the Bayley Scales of Infant Development.</div></div><div><h3>Results</h3><div>Multiple linear regression analysis revealed fetal DHEA levels to be significantly associated with language abilities at six months of age in boys only, with lower DHEA levels corresponding to higher language scores. Control analyses assessing general cognitive abilities showed no association of fetal DHEA levels with infant cognitive function. Testosterone levels were not associated with language.</div></div><div><h3>Conclusions</h3><div>The current study identifies fetal DHEA levels extracted from newborn hair samples as a potential biological factor influencing infant language development in boys.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"183 ","pages":"Article 107663"},"PeriodicalIF":3.6,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145452843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diurnal cortisol trajectories from mid-pregnancy to one year after birth","authors":"Bonnie van Kessel ,&nbsp;Gabrielle R. Rinne ,&nbsp;Michele L. Okun ,&nbsp;Mary Coussons-Read ,&nbsp;Christine Dunkel Schetter ,&nbsp;Kharah M. Ross","doi":"10.1016/j.psyneuen.2025.107664","DOIUrl":"10.1016/j.psyneuen.2025.107664","url":null,"abstract":"<div><h3>Background</h3><div>The hypothalamic-pituitary-adrenal (HPA) axis is involved in the regulation of pregnancy and postpartum recovery. Diurnal cortisol indices, specifically cortisol awakening response (CAR), area under the curve (AUCg), and slope, are ways to study HPA axis activity. Whether these indices show within-person changes during the perinatal period is not clear, nor do we know how maternal sociodemographic, health, or prenatal medical conditions are associated with within-person diurnal cortisol index trajectories. The purpose of this study is to investigate within-person changes in three diurnal cortisol indices from mid-pregnancy to one year postpartum, and test whether sociodemographic, pregnancy, or health factors moderate these changes.</div></div><div><h3>Methods</h3><div>A sample of 172 pregnant women provided saliva samples at six time points from mid-pregnancy to one year after birth. At each time point, they provided samples on two days (wake, 30 + wake, noon, pm). The samples were assayed for cortisol. CAR, slope and AUCg indices were calculated. Piecewise growth curve models tested for within-person changes during pregnancy and postpartum on each index with sociodemographic, pregnancy and health variables included in the models.</div></div><div><h3>Results</h3><div>Within-person trajectories were observed only for AUCg during pregnancy, linear: <em>b</em> = −0.51, <em>p</em> = .012; quadratic: <em>b</em> = −0.45, <em>p</em> = .009, such that AUCg increased from mid to late pregnancy. No significant within-person changes in CAR or slope were observed in pregnancy or after birth. Hispanic women demonstrated increasing CAR in the postpartum year, whereas the opposite was observed for non-Hispanic women. Longer gestation was associated with increasing AUCg after birth.</div></div><div><h3>Conclusion</h3><div>AUCg increased from mid-to-late pregnancy, consistent with prior research. Maternal ethnicity and gestational length moderated diurnal cortisol index trajectories during the postpartum period only.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"183 ","pages":"Article 107664"},"PeriodicalIF":3.6,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145506431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between mental health indicators and genital immune biomarkers among recent survivors of forced sex: A case-control analysis","authors":"Katherine M. Anderson ,&nbsp;Jamila K. Stockman ,&nbsp;Eleanor Capozzi ,&nbsp;Stephanie A. Meyers-Pantele ,&nbsp;Maile Y. Karris ,&nbsp;Fernando Cabezas Mejia ,&nbsp;Ella Meyer ,&nbsp;Melodie A. Nasr ,&nbsp;Mimi Ghosh","doi":"10.1016/j.psyneuen.2025.107662","DOIUrl":"10.1016/j.psyneuen.2025.107662","url":null,"abstract":"<div><div>Sexual violence against women remains pervasive and is associated with HIV risk through sexual violence-related immune dysregulation. We sought to test the associations between mental health indicators and genital immune biomarkers among female survivors of recent sexual violence. Data were drawn from a case-control study of women in San Diego, California who had experienced recent forced or consensual vaginal penetration. Successive adjusted linear regressions models with interaction terms were employed to test moderation of the associations between mental health indicators (perceived stress, depression, PTSD symptoms, and resilience) and inflammatory (interleukin [IL]-1α, IL-1β, IL-6, IL-8, tumor necrosis factor-alpha [TNF-α], macrophage inflammatory protein-3α [MIP3α]), anti-inflammatory/anti-HIV (secretory leukocyte protease inhibitor (SLPI), elafin, and human β-defensin 2 [HBD2]) biomarkers, and percent HIV inhibition, by case/control status. Subsequently, stratified or non-stratified regressions were reported. Overall, participants (n = 64) identified as Hispanic (42.1 %), White (34.4 %), and Black (25.0 %), with a median age of 22 (IQR:18–26). Case participants had higher perceived stress, depression, PTSD symptoms, TNF-α, and SLPI. Analyses indicate differential relationships between cases and controls relating to IL1-α, IL-6, and IL-8, overall suggesting dysregulation of the immune response in cases compared to controls. Results point to a mechanism by which HIV/STI risk can increase in recent sexual violence survivors experiencing PTSD symptoms. Responsively, we suggest biological and behavioral intervention to limit lasting impacts of related trauma.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"183 ","pages":"Article 107662"},"PeriodicalIF":3.6,"publicationDate":"2025-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145467797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}