Respiratory investigation最新文献

{"title":"Clinical characteristics of pulmonary infections caused by Exophiala dermatitidis","authors":"Toshiyuki Yonezawa ,&nbsp;Akiko Nakamura ,&nbsp;Yuka Onda ,&nbsp;Takuma Katano ,&nbsp;Hiroto Murao ,&nbsp;Masaya Fukami ,&nbsp;Tomoyuki Ogisu ,&nbsp;Kenji Baba ,&nbsp;Satoru Ito","doi":"10.1016/j.resinv.2025.101355","DOIUrl":"10.1016/j.resinv.2025.101355","url":null,"abstract":"<div><h3>Background</h3><div><em>Exophiala dermatitidis</em> is a ubiquitous black fungus found in the environment, but the clinical characteristics of <em>E. dermatitidis</em> in respiratory diseases without cystic fibrosis (CF) remain unclear.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed clinical data of non-CF patients who had <em>E. dermatitidis</em> isolated from respiratory specimens.</div></div><div><h3>Results</h3><div>Thirteen patients were enrolled in the study. <em>E. dermatitidis</em> was isolated from sputum aspirated by bronchoscopy (n = 6), sputum (n = 5), bronchoalveolar lavage fluid (n = 1), and empyema pus (n = 1). Preceding pulmonary comorbidities included bronchiectasis (n = 6), COPD (n = 4), nontuberculous <em>Mycobacterium</em> (NTM) infection (n = 3), lung cancer (n = 2), interstitial lung disease (ILD) (n = 2), and asthma (n = 2). Non-pulmonary immunosuppressive comorbidities included diabetes (n = 4), immunosuppressive drug use (n = 3), and malignancies treated with chemotherapy (n = 2). Six patients (46.2 %) were defined as “definite” infection and seven (53.8 %) were as “possible” infection. Levels of serum β-D-glucan (cut-off &lt;20 pg/mL) were elevated in two of 10 patients. Chest CT showed various shadows such as bronchiectasis (n = 9), infiltrative shadow (n = 9), and mucoid impaction (n = 8). Among six patients who were treated with itraconazole (ITCZ), three patients improved, one was unchanged, and two worsened. Despite ITCZ therapy, one patient died due to exacerbation of ILD. In the non-treated group, two patients died due to advanced lung cancer. NTM was also detected with <em>E. dermatitidis</em> in three patients.</div></div><div><h3>Conclusion</h3><div>Our data suggest that <em>E. dermatitidis</em> may cause respiratory infections in patients with bronchiectasis or immunocompromised conditions. Further studies are needed to distinguish colonization from true infection of <em>E. dermatitidis</em> in the respiratory tract.</div></div>","PeriodicalId":20934,"journal":{"name":"Respiratory investigation","volume":"64 1","pages":"Article 101355"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145786957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of persistent pneumothorax after bronchoscopic lung volume reduction successfully treated with video-assisted thoracic surgery without removal of endobronchial valves","authors":"Tadashi Sakaguchi ,&nbsp;Tomohito Tarukawa ,&nbsp;Yoichi Nishii ,&nbsp;Motoshi Takao ,&nbsp;Osamu Hataji","doi":"10.1016/j.resinv.2025.101338","DOIUrl":"10.1016/j.resinv.2025.101338","url":null,"abstract":"<div><div>With proper patient selection excluding collateral ventilation, bronchoscopic lung volume reduction (BLVR) with endobronchial valves (EBVs) offers significant benefits but increases pneumothorax risk. Prioritized management of persistent pneumothorax post-BLVR remains unclear, with both EBV removal and video-assisted thoracic surgery (VATS) considered options. We report a 76-year-old man with severe emphysema who developed persistent pneumothorax and subcutaneous emphysema after left upper lobe BLVR. Following the patient's wishes, VATS was performed instead of EBV removal, resulting in a favorable outcome without delaying BLVR benefits. Depending upon the situation and patient wishes, prioritizing VATS over valve removal may be a reasonable strategy.</div></div>","PeriodicalId":20934,"journal":{"name":"Respiratory investigation","volume":"64 1","pages":"Article 101338"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145616018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erector spinae muscle thickness predicts mortality in patients with pulmonary diseases","authors":"Masafumi Shimoda,&nbsp;Haruka Hamada,&nbsp;Takashi Yoshiyama,&nbsp;Kozo Morimoto,&nbsp;Kozo Yoshimori,&nbsp;Shoji Kudoh","doi":"10.1016/j.resinv.2025.101342","DOIUrl":"10.1016/j.resinv.2025.101342","url":null,"abstract":"<div><h3>Background and objective</h3><div>Loss of skeletal muscle mass contributes to poor respiratory disease outcomes. We previously developed an easy method for assessing physical activity by measuring erector spinae muscle thickness (ESM_T) via routine chest computed tomography (CT). Since chest CT is commonly performed in hospitalized patients with pulmonary diseases, ESM_T can be readily evaluated. In this study, we aimed to investigate the association between ESM_T and 1-year mortality in such patients.</div></div><div><h3>Methods</h3><div>We prospectively enrolled patients hospitalized for pulmonary diseases between February 2023 and January 2024. Among the 636 patients included, 162 died within one year (mortality group), and 474 survived (survival group). ESM_T was compared between the groups, and its correlations with clinical parameters were examined. Subgroup analyses were conducted for patients with major pulmonary conditions to assess the broader clinical utility of ESM_T.</div></div><div><h3>Results</h3><div>Lower ESM_T was significantly associated with higher 1-year mortality risk according to the Cox proportional hazard model (hazard ratio: 0.96, 95 % confidence interval: 0.92–0.99, <em>p</em> = 0.035). An ESM_T ≤20.55 mm predicted increased mortality risk. Subgroup analyses confirmed the associations between low ESM_T and mortality across pneumonia, interstitial lung disease, chronic obstructive pulmonary disease, and nontuberculous mycobacteria and/or bronchiectasis. ESM_T also correlated significantly with age, males, body weight, body mass index, activities of daily living (ADL), pre-admission living place, use of home oxygen therapy, and SARC-F scores.</div></div><div><h3>Conclusion</h3><div>ESM_T is a useful and easy marker for predicting 1-year mortality and impaired ADL status in patients with pulmonary diseases.</div></div>","PeriodicalId":20934,"journal":{"name":"Respiratory investigation","volume":"64 1","pages":"Article 101342"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145681717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To coexist or not to coexist: The evolutionary paradox of the human-microbe relationship","authors":"Hajime Fujimoto","doi":"10.1016/j.resinv.2025.101350","DOIUrl":"10.1016/j.resinv.2025.101350","url":null,"abstract":"","PeriodicalId":20934,"journal":{"name":"Respiratory investigation","volume":"64 1","pages":"Article 101350"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145681718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Long-term effects of inhaled treprostinil in Japanese patients with pulmonary hypertension associated with interstitial lung disease” [Respir Invest, Volume 64, Issue 1, January 2026, 101340]","authors":"Yasuhiro Kondoh ,&nbsp;Takashi Ogura ,&nbsp;Osamu Nishiyama ,&nbsp;Hideyuki Kinoshita ,&nbsp;Takeshi Ogo ,&nbsp;Nobuhiro Tanabe ,&nbsp;Shun Minatsuki ,&nbsp;Kazuhiko Nakayama ,&nbsp;Yu Taniguchi ,&nbsp;Kenta Takahashi ,&nbsp;Takashi Orido ,&nbsp;Seiichiro Sakao","doi":"10.1016/j.resinv.2025.101365","DOIUrl":"10.1016/j.resinv.2025.101365","url":null,"abstract":"","PeriodicalId":20934,"journal":{"name":"Respiratory investigation","volume":"64 1","pages":"Article 101365"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145918434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the COVID-19 pandemic on acute exacerbation of idiopathic pulmonary fibrosis: a nationwide observational study in Japan","authors":"Yuichi Ohteru ,&nbsp;Tomoyuki Kakugawa ,&nbsp;Masahiro Kakugawa ,&nbsp;Tsunahiko Hirano ,&nbsp;Kazuto Matsunaga","doi":"10.1016/j.resinv.2025.11.005","DOIUrl":"10.1016/j.resinv.2025.11.005","url":null,"abstract":"<div><h3>Background</h3><div>The coronavirus disease 2019 (COVID-19) pandemic and associated infection control measures drastically reduced respiratory infections worldwide. This unique context facilitated a natural investigation of the role of respiratory infections in triggering acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF). The aim of this study was to evaluate changes in AE-IPF incidence, seasonality, and prognosis before and during the pandemic using a nationwide Japanese database.</div></div><div><h3>Methods</h3><div>This retrospective cohort study was based on hospitalization data from April 1, 2018 to March 31, 2022. Pandemic-related changes in AE-IPF incidence, seasonal trends, and outcomes were assessed with respect to the pre-pandemic period using mixed-design analysis of variance and Kaplan–Meier survival analysis. For comparison, similar changes in chronic obstructive pulmonary disease (COPD) exacerbation were examined using the same methods.</div></div><div><h3>Results</h3><div>Despite reduced respiratory infections, AE-IPF incidence did not decrease during the pandemic. While the typical winter surge in respiratory infections disappeared during the pandemic, the seasonal increase in AE-IPF incidence during winter persisted. However, the incidence of COPD exacerbations decreased significantly, and the seasonality of exacerbations shifted during the pandemic.</div></div><div><h3>Conclusions</h3><div>The findings of this study question the prior assumption that respiratory infections are key contributors to AE-IPF. While respiratory infections may play a role in some cases, our results suggest that, at least for pre-pandemic respiratory infections, their overall contribution may be less substantial than that previously assumed. This underscores the need to reconsider the pathogenesis of AE-IPF and explore noninfectious mechanisms with regard to its management.</div></div>","PeriodicalId":20934,"journal":{"name":"Respiratory investigation","volume":"64 1","pages":"Article 101326"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145532470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term effects of inhaled treprostinil in Japanese patients with pulmonary hypertension associated with interstitial lung disease","authors":"Yasuhiro Kondoh ,&nbsp;Takashi Ogura ,&nbsp;Osamu Nishiyama ,&nbsp;Hideyuki Kinoshita ,&nbsp;Takeshi Ogo ,&nbsp;Nobuhiro Tanabe ,&nbsp;Shun Minatsuki ,&nbsp;Kazuhiko Nakayama ,&nbsp;Yu Taniguchi ,&nbsp;Kenta Takahashi ,&nbsp;Takashi Orido ,&nbsp;Seiichiro Sakao","doi":"10.1016/j.resinv.2025.101340","DOIUrl":"10.1016/j.resinv.2025.101340","url":null,"abstract":"<div><h3>Background</h3><div>Treprostinil has been approved for pulmonary hypertension associated with interstitial lung disease (PH-ILD) in Japan. This report aimed to evaluate long-term effects of inhaled treprostinil in Japanese patients with PH-ILD based on observation over 52 weeks.</div></div><div><h3>Methods</h3><div>Inhaled treprostinil was administered via a nebulizer from 18 μg (three breaths, four times daily) to 72 μg (12 breaths, four times daily) at minimum 3-day intervals. World Health Organization (WHO) functional class, clinical worsening, adverse events, pulmonary function and ILD-related biomarkers were evaluated throughout the trial.</div></div><div><h3>Results</h3><div>Among 20 patients, 16 and 13 completed the 52-week and 100-week observation periods, respectively. Eleven patients continued on the trial until transitioning to a commercially available product. The reasons of discontinuation in nine patients were adverse events in six patients (including four adverse drug reactions (ADRs)), withdrawal of consent in two patients, and lung transplantation in one patient. The median observation period was 107.5 weeks (interquartile range, 61.4–128.8 weeks) in 20 patients. Among 13 patients observed until week 100, WHO functional class was maintained in 69.2 % (9/13), and improved from class III to class II in 30.8 % (4/13). The main ADRs included cough, malaise, and blood pressure decreased. At the final measurement timepoint in each patient, 70.0 % (14/20) and 83.3 % (15/18) maintained had no absolute decline of forced vital capacity ≥5 % and diffusing capacity for carbon monoxide ≥10 %, respectively.</div></div><div><h3>Conclusion</h3><div>Considering its long-term clinical benefits and tolerability, inhaled treprostinil is a promising treatment option for patients with PH-ILD.</div></div><div><h3>Trial registration</h3><div>Japan Registry of Clinical Trials (jRCT), jRCT2051210016. (first registered: May 7, 2021).</div></div>","PeriodicalId":20934,"journal":{"name":"Respiratory investigation","volume":"64 1","pages":"Article 101340"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145769039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features of Mycobacterium abscessus complex and Mycobacterium kansasii pulmonary disease in Kyushu, Japan","authors":"Kazuaki Takeda ,&nbsp;Takahiro Takazono ,&nbsp;Shotaro Ide ,&nbsp;Masataka Yoshida ,&nbsp;Naoki Iwanaga ,&nbsp;Naoki Hosogaya ,&nbsp;Yusei Tsukamoto ,&nbsp;Satoshi Irifune ,&nbsp;Takayuki Suyama ,&nbsp;Asuka Umemura ,&nbsp;Tomo Mihara ,&nbsp;Akira Kondo ,&nbsp;Tsutomu Kobayashi ,&nbsp;Eisuke Sasaki ,&nbsp;Toyomitsu Sawai ,&nbsp;Yasuhito Higashiyama ,&nbsp;Kohji Hashiguchi ,&nbsp;Minako Hanaka ,&nbsp;Toshihiko Ii ,&nbsp;Kiyoyasu Fukushima ,&nbsp;Hiroshi Mukae","doi":"10.1016/j.resinv.2025.101358","DOIUrl":"10.1016/j.resinv.2025.101358","url":null,"abstract":"<div><h3>Background</h3><div>Nontuberculous mycobacterial pulmonary disease (NTM-PD) is a chronic respiratory infection with a growing incidence and mortality globally. Although the clinical features, treatment, and prognosis of <em>Mycobacterium avium-intracellulare</em> (MAI) pulmonary disease have been extensively reported, evidence regarding non-MAI NTM-PD remains limited.</div></div><div><h3>Methods</h3><div>This retrospective cohort study included patients newly diagnosed with NTM-PD between 2010 and 2017 at 18 hospitals in Kyushu, Japan. Data on baseline characteristics, causative organisms, radiological findings, treatment regimens, and clinical outcomes were collected and analysed.</div></div><div><h3>Results</h3><div>In total, 1317 patients were enrolled. <em>M. intracellulare</em> (50.4 %), <em>M. avium</em> (40.5 %), <em>M. abscessus</em> complex (MABC) (2.4 %), and <em>M. kansasii</em> (2.4 %) were identified as the major causative organisms. Compared with patients with MAI, those with MABC exhibited a lower body mass index and a higher AFB sputum smear positivity rate. Patients with <em>M. kansasii</em> infection were predominantly male, frequently had underlying chronic obstructive pulmonary disease, and presented with cavitary lesions. Treatment initiation rates for MABC and <em>M. kansasii</em> were 71.9 % and 87.5 %, respectively. The response rate to the treatment in sputum mycobacterial evaluation was comparable between the two groups. However, the re-treatment rate was higher in the MABC group (30.4 % vs. 14.3 %). The 10-year mortality rates were 25.0 % and 15.6 % for MABC and <em>M. kansasii</em>, respectively.</div></div><div><h3>Conclusions</h3><div>Initial treatment responses for MABC and <em>M. kansasii</em> were favourable. However, long-term outcomes for MABC remained poor, potentially owing to the limited availability of effective continuation-phase therapies. Further large-scale prospective studies are warranted to understand the clinical management and prognosis of non-MAI NTM-PD.</div></div>","PeriodicalId":20934,"journal":{"name":"Respiratory investigation","volume":"64 1","pages":"Article 101358"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145839206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of hospitalization on health-related quality of life in patients receiving home oxygen therapy: Insights of the Japanese white paper on home respiratory care 2024","authors":"Satoshi Hamada ,&nbsp;Jun Ueki ,&nbsp;Toyohiro Hirai ,&nbsp;Emika Sano ,&nbsp;Keiko Hino ,&nbsp;Megumi Ikeda ,&nbsp;Susumu Sato ,&nbsp;Toru Oga ,&nbsp;Tomomasa Tsuboi ,&nbsp;Hajime Kurosawa ,&nbsp;Hiroo Wada ,&nbsp;the Japanese White Paper on Home Respiratory Care 2024 working group","doi":"10.1016/j.resinv.2025.101341","DOIUrl":"10.1016/j.resinv.2025.101341","url":null,"abstract":"<div><h3>Background</h3><div>There are no available data on the impact of hospitalization on health-related quality of life (HRQoL) in patients receiving home oxygen therapy (HOT). Thus, the present study aimed to examine the association between hospitalization and HRQoL in patients receiving HOT based on the results of the Japanese White Paper on Home Respiratory Care 2024.</div></div><div><h3>Methods</h3><div>Patients receiving HOT who completed the HRQoL section of the patient survey, assessed using the Short Form-8 (SF-8) questionnaire, were included in the analysis. This survey data were collected from December 2021 to March 2023. The SF-8 questionnaire comprised eight subitems and two summary scores (physical component summary [PCS] and mental component summary [MCS]). Hospitalization within the past year were evaluated, excluding those due to coronavirus disease 2019.</div></div><div><h3>Results</h3><div>Totally, 288 patients receiving HOT were examined. In the SF-8 questionnaire survey, all items except body pain and the two summary scores did not differ between patients with chronic obstructive pulmonary disease and those with interstitial lung disease. Patients who had history of hospitalization had lower scores in all eight subitems and in both summary scores than those who did not. Based on a stepwise multiple linear regression analysis, PCS (β = −0.14, p = 0.011) and MCS (β = −0.14, p = 0.014) scores were independently and negatively correlated with hospitalization.</div></div><div><h3>Conclusions</h3><div>A history of hospitalization was independently associated with reduced HRQoL in patients receiving HOT. Prospective studies are needed to clarify underlying mechanisms and to evaluate interventions that may minimize HRQoL decline.</div></div>","PeriodicalId":20934,"journal":{"name":"Respiratory investigation","volume":"64 1","pages":"Article 101341"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145616022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of individuals with COPD using biometric voice and cough sound features","authors":"Yasushi Obase ,&nbsp;Susumu Fukahori ,&nbsp;Jun Iriki ,&nbsp;Takahiro Takazono ,&nbsp;Yusei Tsukamoto ,&nbsp;Shinnosuke Takemoto ,&nbsp;Noriho Sakamoto ,&nbsp;Yusuke Hamanaka ,&nbsp;Hideaki Watanabe ,&nbsp;Kazumi Hirano ,&nbsp;Chizu Fukushima ,&nbsp;Tomoya Nishino ,&nbsp;Hiroshi Mukae","doi":"10.1016/j.resinv.2025.101353","DOIUrl":"10.1016/j.resinv.2025.101353","url":null,"abstract":"<div><h3>Background</h3><div>Chronic obstructive pulmonary disease (COPD), a major global health burden linked to smoking, is frequently underdiagnosed due to low awareness and delayed symptom recognition. This study explored the feasibility of non-invasive voice and cough sound analysis for COPD identification.</div></div><div><h3>Methods</h3><div>In this prospective study, 55 participants (26 with COPD, 29 without) underwent pulmonary function testing and provided sociodemographic and clinical data. Speech and cough sounds were recorded three times per participant and processed using acoustic feature extraction, feature selection via the minimum redundancy maximum relevance algorithm, and logistic regression classification. Model performance was evaluated using four-fold cross-validation. Statistical analysis was conducted with JMP software (p &lt; 0.05).</div></div><div><h3>Results</h3><div>The vowel sound/u/showed statistically significant discriminatory ability in the mixed-gender cohort, but sensitivity and specificity were both below 80 %, indicating limited diagnostic performance. When restricted to male participants, both metrics exceeded 80 %, suggesting higher discriminatory power. Smartphone recordings yielded comparable accuracy to integrated circuit recorders. Adding COPD assessment test scores and smoking history did not improve classification.</div></div><div><h3>Conclusions</h3><div>Voice analysis may offer a non-invasive screening approach for COPD. However, this study was limited to male participants and a single disease target, restricting generalizability. Future research will expand to include related respiratory conditions such as bronchiectasis and assess performance across sexes and disease types.</div></div>","PeriodicalId":20934,"journal":{"name":"Respiratory investigation","volume":"64 1","pages":"Article 101353"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}