Pub Date : 2021-07-15DOI: 10.18231/J.JPBS.2021.004
E. C. Ogbodo, B. Ugorji, S. Meludu, I. Ogbu, D. O. Chikezie, C. F. Igwebuobi, N. Nduka
Turmeric is a perennial plant of ginger family serving as an effective nutritional supplement that has major benefits for the body and brain. The major benefits stretch from anti-inflammatory, antioxidant, anticancer, anti-arthritic, anti-aging to improving brain functions as well as its possible property of lowering sugar, lipids and increasing calcium. Due to fluctuation in estrogen, perimenopausal women are at high risk of heart disease, diabetes and osteoporosis. This study investigates the effect of turmeric on lipid profile and some biochemical parameters in perimenopausal women. Sixty apparently healthy women of perimenopausal age were selected and treated for three months with turmeric. Blood sample were collected at baseline, first, second and third month of treatments. Serum was evaluated for lipid profile, fasting blood sugar and calcium. Measurements of their anthropometric parameters were taken at every level. The mean anthropometric parameters showed that weight p=0.045, WC p=0.043 was significantly lower after three months of treatment while SBP p=0.000, DBP p=0.009 was significantly increased after three months of treatment. Calcium concentration increased though not significant but FBS significantly decreased to 4.83±0.41 (p=0.004) after three months of treatment. HDL increased significantly to 1.30 ± 0.11 (p=0.0001) after three months of treatment. This study showed that turmeric increases calcium and HDL-c concentration, reduces weight, waist circumference, FBS, TC, TG, LDL, VLDL and moderates systolic and diastolic blood pressure. Thus, it serves as an alternative remedy in management of menopausal symptoms.
{"title":"Changes in lipd profile and some biochemical parameters in perimenopausal women treated with turmeric","authors":"E. C. Ogbodo, B. Ugorji, S. Meludu, I. Ogbu, D. O. Chikezie, C. F. Igwebuobi, N. Nduka","doi":"10.18231/J.JPBS.2021.004","DOIUrl":"https://doi.org/10.18231/J.JPBS.2021.004","url":null,"abstract":"Turmeric is a perennial plant of ginger family serving as an effective nutritional supplement that has major benefits for the body and brain. The major benefits stretch from anti-inflammatory, antioxidant, anticancer, anti-arthritic, anti-aging to improving brain functions as well as its possible property of lowering sugar, lipids and increasing calcium. Due to fluctuation in estrogen, perimenopausal women are at high risk of heart disease, diabetes and osteoporosis. This study investigates the effect of turmeric on lipid profile and some biochemical parameters in perimenopausal women. Sixty apparently healthy women of perimenopausal age were selected and treated for three months with turmeric. Blood sample were collected at baseline, first, second and third month of treatments. Serum was evaluated for lipid profile, fasting blood sugar and calcium. Measurements of their anthropometric parameters were taken at every level. The mean anthropometric parameters showed that weight p=0.045, WC p=0.043 was significantly lower after three months of treatment while SBP p=0.000, DBP p=0.009 was significantly increased after three months of treatment. Calcium concentration increased though not significant but FBS significantly decreased to 4.83±0.41 (p=0.004) after three months of treatment. HDL increased significantly to 1.30 ± 0.11 (p=0.0001) after three months of treatment. This study showed that turmeric increases calcium and HDL-c concentration, reduces weight, waist circumference, FBS, TC, TG, LDL, VLDL and moderates systolic and diastolic blood pressure. Thus, it serves as an alternative remedy in management of menopausal symptoms.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79063420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-15DOI: 10.18231/J.JPBS.2021.001
S. Chaudhry
Vertigo is a sense of spinning dizziness. There is no ideal medicine for treatment of vertigo and dizziness. The duration of dizziness/vertigo: attacks may last for seconds or minutes (as in vestibular paroxysm) or hours (as in Menière’s disease or vestibular migraine). Diagnosis and treatment of vertigo remains a challenge for many physicians. Many drugs produce dizziness and vertigo side effects such as some antibiotics , diuretics, mucolytics and NSAIDs. Symptoms of Vertigo are usually managed with vestibular suppressants. Steroids are useful in selected patients. Neurosurgical treatment is chosen in lesions such as hematomas, tumors, vascular lesions, pathology of the cervical spine (cervicalspondylopathy)
{"title":"Scrupulously managing vertigo","authors":"S. Chaudhry","doi":"10.18231/J.JPBS.2021.001","DOIUrl":"https://doi.org/10.18231/J.JPBS.2021.001","url":null,"abstract":"Vertigo is a sense of spinning dizziness. There is no ideal medicine for treatment of vertigo and dizziness. The duration of dizziness/vertigo: attacks may last for seconds or minutes (as in vestibular paroxysm) or hours (as in Menière’s disease or vestibular migraine). Diagnosis and treatment of vertigo remains a challenge for many physicians. Many drugs produce dizziness and vertigo side effects such as some antibiotics , diuretics, mucolytics and NSAIDs. Symptoms of Vertigo are usually managed with vestibular suppressants. Steroids are useful in selected patients. Neurosurgical treatment is chosen in lesions such as hematomas, tumors, vascular lesions, pathology of the cervical spine (cervicalspondylopathy)","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85960103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-15DOI: 10.18231/J.JPBS.2021.002
R. Kulkarni, R. Pandhare, V. Deshmukh, P. Mohite, A. Pawar
HPTLC is an advanced type of planar chromatography used extensively in the recent years for fingerprinting of medicinal plants, products and for screening lichen substances, quantification of active ingredients and herbal drugs, phytochemical and biomedical analysis and also used to check of presence of adulterants in the formulation. It is more sensitive and possible to run more sample in a short period of time, by using small amount of solvent. It is one of the sophisticated instrumental techniques based on the full capabilities of thin layer chromatography. In this paper, a brief discussion of the type of instrument used in HPTLC, its entire approach, and how this procedure is superior to TLC is presented. This article attempts to concentrate on the use of HPTLC by including examples of medications, medicinal drugs, and formulations that have been analyzed using HPTLC.
{"title":"High-performance thin layer chromatography: A powerful analytical technique in pharmaceutical drug discovery","authors":"R. Kulkarni, R. Pandhare, V. Deshmukh, P. Mohite, A. Pawar","doi":"10.18231/J.JPBS.2021.002","DOIUrl":"https://doi.org/10.18231/J.JPBS.2021.002","url":null,"abstract":"HPTLC is an advanced type of planar chromatography used extensively in the recent years for fingerprinting of medicinal plants, products and for screening lichen substances, quantification of active ingredients and herbal drugs, phytochemical and biomedical analysis and also used to check of presence of adulterants in the formulation. It is more sensitive and possible to run more sample in a short period of time, by using small amount of solvent. It is one of the sophisticated instrumental techniques based on the full capabilities of thin layer chromatography. In this paper, a brief discussion of the type of instrument used in HPTLC, its entire approach, and how this procedure is superior to TLC is presented. This article attempts to concentrate on the use of HPTLC by including examples of medications, medicinal drugs, and formulations that have been analyzed using HPTLC.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77062226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-15DOI: 10.18231/J.JPBS.2021.005
H. S. Patil, R. Sharma
An extensive survey of floristic of native and invasive weed species was carried out during 2016 to 2019 in the semiarid agro ecosystem of Baramati Tahsil, Dist- Pune (M.S.). About 18 dominant invasive weeds such as Ageratum, Alternanthera, Croton., Xanthium, Parthenium and Tridax were encroaching the natives, becoming a serious threat to the major crops of this area such as wheat, sorghum, pearl millet, mung bean, pigeon pea, chillies and tomato. Amongst these Croton bonplandianus was highly dominant and wide spreading. Hence, its allelopathic potential was investigated. The allelopathic influence of leaf and root leachates as well as extracts of Croton bonplandianus Bail. was examined on seed germination of mung bean (Vigna radiata L.). The germination assay revealed that allelopathic potential and other factors are responsible for its dominance and successful invasion. The allelopathic influence of rhizosphere soil and its aqueous leachates indicated that both are responsible for inhibiting the seed germination and seedling growth of mungbean. Both the experiments have clearly confirmed the allelopathic potential of Croton bonplandianus. The HPTLC analyses confirmed the existence of a broad groups of allelochemicals like terpenoides, steroids, flavonoids, pungent and bitter essential oils and phenolics in its leaves and roots, which confirmed its allelopathic potential. Further characterization of above mentioned allelochemicals is in progress.
{"title":"Allelopathic potential of croton bonplandianus bail","authors":"H. S. Patil, R. Sharma","doi":"10.18231/J.JPBS.2021.005","DOIUrl":"https://doi.org/10.18231/J.JPBS.2021.005","url":null,"abstract":"An extensive survey of floristic of native and invasive weed species was carried out during 2016 to 2019 in the semiarid agro ecosystem of Baramati Tahsil, Dist- Pune (M.S.). About 18 dominant invasive weeds such as Ageratum, Alternanthera, Croton., Xanthium, Parthenium and Tridax were encroaching the natives, becoming a serious threat to the major crops of this area such as wheat, sorghum, pearl millet, mung bean, pigeon pea, chillies and tomato. Amongst these Croton bonplandianus was highly dominant and wide spreading. Hence, its allelopathic potential was investigated. The allelopathic influence of leaf and root leachates as well as extracts of Croton bonplandianus Bail. was examined on seed germination of mung bean (Vigna radiata L.). The germination assay revealed that allelopathic potential and other factors are responsible for its dominance and successful invasion. The allelopathic influence of rhizosphere soil and its aqueous leachates indicated that both are responsible for inhibiting the seed germination and seedling growth of mungbean. Both the experiments have clearly confirmed the allelopathic potential of Croton bonplandianus. The HPTLC analyses confirmed the existence of a broad groups of allelochemicals like terpenoides, steroids, flavonoids, pungent and bitter essential oils and phenolics in its leaves and roots, which confirmed its allelopathic potential. Further characterization of above mentioned allelochemicals is in progress.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89511411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-15DOI: 10.18231/J.JPBS.2021.008
A. Vadivelu
Myeloperoxidase (MPO) is a heterodimeric, cationic and glycosylated haeme enzyme which gets released under increased oxidative stress producing neutrophil oxidant, hypochlorous acid having the capacity to modify various biomolecules by chlorination and/or oxidation of sulfhydryl groups in proteins causing their inactivation and promoting inflammatory tissue damage. Different levels of hypochlorus acid are used as a trait marker for prescribing the disorders e.g. atherosclerosis, rheumatoid arthritis, lung cancer, Immuno-reactivity. Mini library of 22500 2,5disubstituted 1,3,4 thiadiazoles were docked with Myeloperoxidase in order to identify the potent inhibitor against the enzyme. The chemical nature of the protein and ligands greatly influence the performance of docking process. Keeping this fact in view, critical evaluation of the performance was performed by GLIDE by HTVS, SP and XP. The ADME parameters by QIKPROP and protein-ligand binding free energies were calculated using the Prime/MM-GBSA module of Schrödinger.Both hydrogen bonding and hydrophobic interactions contributed significantly for its ligand binding and core influence the target site through prominent hydrophobic and charged interaction with the backbone and side chain residues in the target site that improves the affinity of the molecule. The compound selected as potent inhibitor is having minimum binding affinity, maximum GScore and minimum FlexX energy. The amino acids residues ASP98, ASP94, THR100 and GLU 102 in the MPO gene domain active site form hydrogen bonds with the ligand. Compounds 3350-5150 showed better interaction with haeme enzyme for further understanding of structures, reliability and Biomolecularactivityy in connection with oxidative stress induced disorders.
{"title":"Molecular docking studies of 1,3,4 -thiadiazoles as myeloperoxidase inhibitors","authors":"A. Vadivelu","doi":"10.18231/J.JPBS.2021.008","DOIUrl":"https://doi.org/10.18231/J.JPBS.2021.008","url":null,"abstract":"Myeloperoxidase (MPO) is a heterodimeric, cationic and glycosylated haeme enzyme which gets released under increased oxidative stress producing neutrophil oxidant, hypochlorous acid having the capacity to modify various biomolecules by chlorination and/or oxidation of sulfhydryl groups in proteins causing their inactivation and promoting inflammatory tissue damage. Different levels of hypochlorus acid are used as a trait marker for prescribing the disorders e.g. atherosclerosis, rheumatoid arthritis, lung cancer, Immuno-reactivity. Mini library of 22500 2,5disubstituted 1,3,4 thiadiazoles were docked with Myeloperoxidase in order to identify the potent inhibitor against the enzyme. The chemical nature of the protein and ligands greatly influence the performance of docking process. Keeping this fact in view, critical evaluation of the performance was performed by GLIDE by HTVS, SP and XP. The ADME parameters by QIKPROP and protein-ligand binding free energies were calculated using the Prime/MM-GBSA module of Schrödinger.Both hydrogen bonding and hydrophobic interactions contributed significantly for its ligand binding and core influence the target site through prominent hydrophobic and charged interaction with the backbone and side chain residues in the target site that improves the affinity of the molecule. The compound selected as potent inhibitor is having minimum binding affinity, maximum GScore and minimum FlexX energy. The amino acids residues ASP98, ASP94, THR100 and GLU 102 in the MPO gene domain active site form hydrogen bonds with the ligand. Compounds 3350-5150 showed better interaction with haeme enzyme for further understanding of structures, reliability and Biomolecularactivityy in connection with oxidative stress induced disorders.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83012890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-15DOI: 10.18231/J.JPBS.2021.006
A. Ogunkunle, J. E. Ideh, G. Olaniran, F. O. Olu
Maloff-HB is a documented traditional oral powdered herbal drug in Ogbomoso, Nigeria whose botanical constituents, ascorbic acid and mineral elements composition have been quantified but there is inadequate information on the pharmacognostic properties of the nine herbal materials for its formulation. This study therefore sought to elucidate the bark and wood anatomy of eight of the nine herbs used in the formulation, and identify the diagnostic markers for their authentication. The conventional anatomical techniques of transverse sectioning (TS) and tissue maceration (TIM) were used to draw out 21 characteristics from the root barks of the eight woody species studied. In addition, 41 features of the wood in the roots of three of the species were drawn using TS, transverse longitudinal sectioning (TLS), radial longitudinal sectioning (RLS) and TIM. Following staining, mounting and microscopic examinations, the observed qualitative and quantitative features were taxonomically described in accordance with the provisions of International Association of Wood Anatomists, and their diagnostic values among the medicinal herbs were explored. Bark anatomical markers that are clearly diagnostic of the species studied included features of the secondary cortex, phloem rays, axial parenchyma, sclereids and resin ducts. In the wood, these included features of the vessels in the TS and variable ray characteristics in the TLS. The two artificial keys obtained from discontinuities in qualitative and quantitative features observed in the barks and the woods are useful tools for reliable identification of the herbal materials studied.
Maloff-HB是尼日利亚Ogbomoso记载的一种传统口服粉末草药，其植物成分、抗坏血酸和矿物元素组成已被量化，但其配方中九种草药材料的生药学特性信息不足。因此，本研究试图阐明配方中使用的九种草药中的八种草药的树皮和木材解剖结构，并确定其认证的诊断标记。采用传统的横切面(TS)和组织浸渍(TIM)解剖技术，从8种木本植物的根皮中提取了21个特征。此外，利用TS、横向纵向切片(TLS)、径向纵向切片(RLS)和TIM绘制了3种树种根系的41个特征。根据国际木材解剖学家协会(International Association of Wood Anatomists)的规定，对所观察到的定性和定量特征进行分类描述，并探讨其在药材中的诊断价值。树皮解剖标记包括次生皮质、韧皮部射线、轴向薄壁、硬核和树脂导管的特征。在木材中，这些特征包括TS中的血管特征和TLS中的可变射线特征。从树皮和木材中观察到的定性和定量特征的不连续性中获得的两个人工钥匙是可靠识别所研究的草药材料的有用工具。
{"title":"Aspects of pharmacognostic evaluation of the herbs for a traditional antimalarial (maloff-hb) powdered formulation in ogbomoso, Nigeria","authors":"A. Ogunkunle, J. E. Ideh, G. Olaniran, F. O. Olu","doi":"10.18231/J.JPBS.2021.006","DOIUrl":"https://doi.org/10.18231/J.JPBS.2021.006","url":null,"abstract":"Maloff-HB is a documented traditional oral powdered herbal drug in Ogbomoso, Nigeria whose botanical constituents, ascorbic acid and mineral elements composition have been quantified but there is inadequate information on the pharmacognostic properties of the nine herbal materials for its formulation. This study therefore sought to elucidate the bark and wood anatomy of eight of the nine herbs used in the formulation, and identify the diagnostic markers for their authentication. The conventional anatomical techniques of transverse sectioning (TS) and tissue maceration (TIM) were used to draw out 21 characteristics from the root barks of the eight woody species studied. In addition, 41 features of the wood in the roots of three of the species were drawn using TS, transverse longitudinal sectioning (TLS), radial longitudinal sectioning (RLS) and TIM. Following staining, mounting and microscopic examinations, the observed qualitative and quantitative features were taxonomically described in accordance with the provisions of International Association of Wood Anatomists, and their diagnostic values among the medicinal herbs were explored. Bark anatomical markers that are clearly diagnostic of the species studied included features of the secondary cortex, phloem rays, axial parenchyma, sclereids and resin ducts. In the wood, these included features of the vessels in the TS and variable ray characteristics in the TLS. The two artificial keys obtained from discontinuities in qualitative and quantitative features observed in the barks and the woods are useful tools for reliable identification of the herbal materials studied.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85365727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-15DOI: 10.18231/J.JPBS.2021.003
Naseef Pp, M. MohammedFavas, Ahammad Rashid Vk, K. AbdulVajid, Muhas C, K. MohamedSaheer
Cancer is one amongst the key causes of mortality worldwide and advanced techniques for medical aid are desperately required. Hence, the most aim of this review is to supply info regarding the engineering in cancer medical aid. The development of novel nano materials and nanocarriers has allowed a serious drive to boost drug delivery in cancer. The major aim of most nanocarrier application has been to safeguard the drug from speedy degradation when general delivery and permitting it to achieve tumour at therapeutic concentration and avoiding drug delivery to traditional site the maximum amount as attainable to scale back ADRs. Nanotechnology is additionally employed in several incurable diseases like HIV, protozoal infection and Alzheimer apart from cancer. Hence, during this review we tend to target many nanotechnologies and improved ways in nanocarrier style for the cancer in addition as many incurable unwellness therapies.
{"title":"Recent development in applications of nano-science in incurable diseases: A review","authors":"Naseef Pp, M. MohammedFavas, Ahammad Rashid Vk, K. AbdulVajid, Muhas C, K. MohamedSaheer","doi":"10.18231/J.JPBS.2021.003","DOIUrl":"https://doi.org/10.18231/J.JPBS.2021.003","url":null,"abstract":"Cancer is one amongst the key causes of mortality worldwide and advanced techniques for medical aid are desperately required. Hence, the most aim of this review is to supply info regarding the engineering in cancer medical aid. The development of novel nano materials and nanocarriers has allowed a serious drive to boost drug delivery in cancer. The major aim of most nanocarrier application has been to safeguard the drug from speedy degradation when general delivery and permitting it to achieve tumour at therapeutic concentration and avoiding drug delivery to traditional site the maximum amount as attainable to scale back ADRs. Nanotechnology is additionally employed in several incurable diseases like HIV, protozoal infection and Alzheimer apart from cancer. Hence, during this review we tend to target many nanotechnologies and improved ways in nanocarrier style for the cancer in addition as many incurable unwellness therapies.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89411641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-15DOI: 10.18231/J.JPBS.2020.013
N. Patiyal, A. Bhardwaj, D. Kansal, A. Sood, Ankit Chauhan
Levetiracetam has been associated with aggressive behavior and mania.We are reporting a case of agitation and aggressive behavior following levetiracetam monotherapy for focal seizure prophylaxis. A 48 years old man, who presented to the neurology department with history of four episodes of sudden onset abnormal body movements. Patient was diagnosed with focal seizures with secondary generalization and was prescribed tablet levetiracetam 500 mg twice a day for seizure prophylaxis. Three weeks later patient presented with complaints of excessive sleepiness during daytime, agitation and aggressive behavior, though seizure free. According to World Health Organization Uppsala monitoring Centre (WHO-UMC) causality assessment system the case was classified as probable/likely for levetiracetam-induced altered behavior. Levetiracetam was discontinued, and tablet carbamazepine controlled-release 300 mg twice daily was substituted. Within 2 days of switching therapy the agitation and aggression reduced substantially. Although levetiracetam has fewer side effects than traditional antiepileptic medications, but it is imperative to continuously monitor the patient for infrequent adverse effects also, so that required modifications to drug label may be done. Keywords: Aggression, Agitation, Altered behavior, Levetiracetam.
{"title":"Altered Behavior: An Infrequent Presentation with Levetiracetam","authors":"N. Patiyal, A. Bhardwaj, D. Kansal, A. Sood, Ankit Chauhan","doi":"10.18231/J.JPBS.2020.013","DOIUrl":"https://doi.org/10.18231/J.JPBS.2020.013","url":null,"abstract":"Levetiracetam has been associated with aggressive behavior and mania.We are reporting a case of agitation and aggressive behavior following levetiracetam monotherapy for focal seizure prophylaxis. A 48 years old man, who presented to the neurology department with history of four episodes of sudden onset abnormal body movements. Patient was diagnosed with focal seizures with secondary generalization and was prescribed tablet levetiracetam 500 mg twice a day for seizure prophylaxis. Three weeks later patient presented with complaints of excessive sleepiness during daytime, agitation and aggressive behavior, though seizure free. According to World Health Organization Uppsala monitoring Centre (WHO-UMC) causality assessment system the case was classified as probable/likely for levetiracetam-induced altered behavior. Levetiracetam was discontinued, and tablet carbamazepine controlled-release 300 mg twice daily was substituted. Within 2 days of switching therapy the agitation and aggression reduced substantially. Although levetiracetam has fewer side effects than traditional antiepileptic medications, but it is imperative to continuously monitor the patient for infrequent adverse effects also, so that required modifications to drug label may be done.\u0000\u0000Keywords: Aggression, Agitation, Altered behavior, Levetiracetam.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81585550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-15DOI: 10.18231/J.JPBS.2020.009
S. Chaudhry
Trigeminal Neuralgia (TN) is orofacial pain restricted to one or more divisions of the trigeminal nerve Attacks of intense, electric shock-like facial pain can occur without warning or be triggered by touching specific areas of the face by movements, brushing, laughing or following emotional stimuli. The exact cause of trigeminal neuralgia is not fully elucidated, a blood vessel is often found compressing the nerve. TN dramatically reduces the quality of life of affected individuals not only due to pain attacks but also to other disease-associated comorbidities, such as anxiety and depression. The Therapy used is often conservative with variable results. Keywords: Pain, Anxiety, Carbamazepine, Stem cells, Microvascular decompression.
{"title":"Management of Trigeminal Neuralgia","authors":"S. Chaudhry","doi":"10.18231/J.JPBS.2020.009","DOIUrl":"https://doi.org/10.18231/J.JPBS.2020.009","url":null,"abstract":"Trigeminal Neuralgia (TN) is orofacial pain restricted to one or more divisions of the trigeminal nerve Attacks of intense, electric shock-like facial pain can occur without warning or be triggered by touching specific areas of the face by movements, brushing, laughing or following emotional stimuli. The exact cause of trigeminal neuralgia is not fully elucidated, a blood vessel is often found compressing the nerve. TN dramatically reduces the quality of life of affected individuals not only due to pain attacks but also to other\u0000disease-associated comorbidities, such as anxiety and depression. The Therapy used is often conservative with variable results.\u0000\u0000Keywords: Pain, Anxiety, Carbamazepine, Stem cells, Microvascular decompression.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74723510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-15DOI: 10.18231/J.JPBS.2020.014
K. Rani
Herbal therapy is well known holistic therapeutic approach from ancient times to improve emotional, mental and spiritual integrality because not having considerable side effects or adverse effects upon consumption and administration. Although medicinal plants or herbal formulations are widely proposed and considered to be safe, however, they can be potentially be hepatotoxic if not processed properly for final formulation stage to be used for consumption. Hence, simultaneous use of herbs with therapeutic drugs is considered or accepted these days which lead to increases the clinical potential of herb-drug interactions to treat many fatal diseases like hepatitis, cancer and various neurological disorders etc. However, these random or self-guided use of herbal medicine and supplements can be risky because most of times, they are not subject to review by the FDA. Hence, we need healthy attempts to find out possible reasons for studying streamlined clinical toxicological interpretations and clinical pharmacological approaches of herbal products before considering them for their further use as complementary and alternative medicine combination therapies to treat any diseases. Keywords: Herbal products, Herbal medicines, Herbal remedies, Medicinal plants.
{"title":"Cogent note on raised safety concern on concurrent uses of herbal formulations","authors":"K. Rani","doi":"10.18231/J.JPBS.2020.014","DOIUrl":"https://doi.org/10.18231/J.JPBS.2020.014","url":null,"abstract":"Herbal therapy is well known holistic therapeutic approach from ancient times to improve emotional, mental and spiritual integrality because not having considerable side effects or adverse effects upon consumption and administration. Although medicinal plants or herbal formulations are widely proposed and considered to be safe, however, they can be potentially be hepatotoxic if not processed properly for final formulation stage to be used for consumption. Hence, simultaneous use of herbs with therapeutic drugs is considered or accepted these days which lead to increases the clinical potential of herb-drug interactions to treat many fatal diseases like hepatitis, cancer and various neurological disorders etc. However, these random or self-guided use of herbal medicine and supplements can be risky because most of times, they are not subject to review by the FDA. Hence, we need healthy attempts to find out possible reasons for studying streamlined clinical toxicological interpretations and clinical pharmacological approaches of herbal products before considering them for their further use as complementary and alternative medicine combination therapies to treat any diseases.\u0000\u0000Keywords: Herbal products, Herbal medicines, Herbal remedies, Medicinal plants.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77562322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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