Pub Date : 2024-04-08DOI: 10.25135/rnp.453.2402.3149
Wei Zhang, Qi Wang
: An investigation of the secondary metabolites of the sea sediment-derived Penicillium sp. LPFH-ZW-1 resulted in the identification of a new compound, named penicipeneacid ( 1 ), along with seven known compounds. The structures of these compounds were established by extensive analysis of the 1D and 2D NMR data, combined with HRESIMS data. The absolute configuration of 1 was determined by comparing the experimental and predicted ECD spectra. The bicyclo[4.1.0]heptane nucleus in compounds 1 and 2 was rarely found in nature. The known compounds were identified to be sesquicaranoic acid B ( 2 ), 9-cycloneren-3,7,11-triol ( 3 ), fumiquinazoline J ( 4 ), versiquinazoline H ( 5 ), penipurdin A ( 6 ), questinol ( 7 ), and 2-hydroxy-4-ethoxybenzoic acid ( 8 ). Compounds 4 and 7 exhibited moderate cytotoxicity against MCF-7 and K562 tumor cell lines, with IC 50 values ranging from 12.6 to 37.1 M.
{"title":"A New Sesquiterpene from the Fungus Penicillium sp. LPFH-hzw-zw1","authors":"Wei Zhang, Qi Wang","doi":"10.25135/rnp.453.2402.3149","DOIUrl":"https://doi.org/10.25135/rnp.453.2402.3149","url":null,"abstract":": An investigation of the secondary metabolites of the sea sediment-derived Penicillium sp. LPFH-ZW-1 resulted in the identification of a new compound, named penicipeneacid ( 1 ), along with seven known compounds. The structures of these compounds were established by extensive analysis of the 1D and 2D NMR data, combined with HRESIMS data. The absolute configuration of 1 was determined by comparing the experimental and predicted ECD spectra. The bicyclo[4.1.0]heptane nucleus in compounds 1 and 2 was rarely found in nature. The known compounds were identified to be sesquicaranoic acid B ( 2 ), 9-cycloneren-3,7,11-triol ( 3 ), fumiquinazoline J ( 4 ), versiquinazoline H ( 5 ), penipurdin A ( 6 ), questinol ( 7 ), and 2-hydroxy-4-ethoxybenzoic acid ( 8 ). Compounds 4 and 7 exhibited moderate cytotoxicity against MCF-7 and K562 tumor cell lines, with IC 50 values ranging from 12.6 to 37.1 M.","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140731176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-08DOI: 10.25135/rnp.452.2402.3145
J. Sichaem, Ngoc‐Hong Nguyen, Chuong Hoang Nguyen, Dinh-Manh Nguyen, A. D. Huynh, T. Duong, Hoang-Thanh Kpa, Thi-Kim-Dung Le, Thi-Ngoc-Duyen Nguyen, H. T. Nguyen, Boi-Phong Vuong
{"title":"Antimicrobial and α-Glucosidase Inhibitory Compounds from the Branches of Uvaria siamensis","authors":"J. Sichaem, Ngoc‐Hong Nguyen, Chuong Hoang Nguyen, Dinh-Manh Nguyen, A. D. Huynh, T. Duong, Hoang-Thanh Kpa, Thi-Kim-Dung Le, Thi-Ngoc-Duyen Nguyen, H. T. Nguyen, Boi-Phong Vuong","doi":"10.25135/rnp.452.2402.3145","DOIUrl":"https://doi.org/10.25135/rnp.452.2402.3145","url":null,"abstract":"","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140732490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A New Prenylated Coumarin from the Roots of Toddalia asiatica","authors":"Xun He, Aifen Zeng, Zhengkuan Zhang, Guobo Xu, Shanggao Liao, Qin-Feng Zhu","doi":"10.25135/rnp.449.2401.3015","DOIUrl":"https://doi.org/10.25135/rnp.449.2401.3015","url":null,"abstract":"","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140241925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-09DOI: 10.25135/rnp.448.2312.2993
Leyla Guven, Adem Ertürk, Mustafa Abdullah Yılmaz, Saleh H. Alwasel, İlhami Gülçin
{"title":"Alchemilla pseudocartalinica Juz: Phytochemical Screening by UPLC-MS/MS, Molecular Docking, Anti-oxidant, Anti-diabetic, Anti-glaucoma, and Anti-Alzheimer Effects","authors":"Leyla Guven, Adem Ertürk, Mustafa Abdullah Yılmaz, Saleh H. Alwasel, İlhami Gülçin","doi":"10.25135/rnp.448.2312.2993","DOIUrl":"https://doi.org/10.25135/rnp.448.2312.2993","url":null,"abstract":"","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140255675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: There are seven species in the genus Nageia , a member of the Podocarpaceae family; five are found in China. They are primarily found in eastern and southern Asia, close to the equator at the 30th parallel north and south, and in coastal mountainous areas and islands in the western Pacific. These herbs are extremely valuable for medicinal purposes. The three species of Nageia that are the subject of most current research on their chemical composition and pharmacological properties are N. nagi , N. fleuryi , and N. wallichiana . There are currently 232 known chemical components, which include steroids, flavonoids, sesquiterpenoids, and diterpenoids. Of these, 86 diterpenoid dilactones comprise most of the chemical components, and only plants of the Nageia genus contain C-ring decarbonized diterpenoid dilactones. These plants exhibit promising pharmacological activities such as anti-tumor, antioxidant, antibacterial, and anti-inflammatory properties. For the first time, an in-depth and systematic evaluation of the chemical constituents and pharmacological properties of plants in the Nageia genus is presented in the this article. This theoretical framework will help in the future investigation and development of medicinal resources and active ingredients within the genus.
:荚蒾科荚蒾属有 7 个种，中国有 5 个种。它们主要分布在亚洲东部和南部，南北纬 30 度赤道附近，以及西太平洋沿海山区和岛屿。这些草药具有极高的药用价值。目前对其化学成分和药理特性研究最多的三个 Nageia 品种是 N. nagi、N. fleuryi 和 N. wallichiana。目前已知的化学成分有 232 种，包括类固醇、类黄酮、倍半萜和二萜。其中，86 种二萜类二内酯构成了大部分化学成分，只有 Nageia 属植物含有 C 环脱碳二萜类二内酯。这些植物具有抗肿瘤、抗氧化、抗菌和抗炎等药理活性。本文首次对 Nageia 属植物的化学成分和药理特性进行了深入系统的评估。这一理论框架将有助于今后研究和开发该属植物的药用资源和活性成分。
{"title":"Chemical Constituents and Pharmacological Activities of the Genus Nageia","authors":"Lin Ni, Lijun Zou, Xiao Chen, Jialin Zhang, Qi Sun, Shuoshuo Fu, Sha Yang, Hui-you Xu, Jian Zhou","doi":"10.25135/rnp.435.2311.2979","DOIUrl":"https://doi.org/10.25135/rnp.435.2311.2979","url":null,"abstract":": There are seven species in the genus Nageia , a member of the Podocarpaceae family; five are found in China. They are primarily found in eastern and southern Asia, close to the equator at the 30th parallel north and south, and in coastal mountainous areas and islands in the western Pacific. These herbs are extremely valuable for medicinal purposes. The three species of Nageia that are the subject of most current research on their chemical composition and pharmacological properties are N. nagi , N. fleuryi , and N. wallichiana . There are currently 232 known chemical components, which include steroids, flavonoids, sesquiterpenoids, and diterpenoids. Of these, 86 diterpenoid dilactones comprise most of the chemical components, and only plants of the Nageia genus contain C-ring decarbonized diterpenoid dilactones. These plants exhibit promising pharmacological activities such as anti-tumor, antioxidant, antibacterial, and anti-inflammatory properties. For the first time, an in-depth and systematic evaluation of the chemical constituents and pharmacological properties of plants in the Nageia genus is presented in the this article. This theoretical framework will help in the future investigation and development of medicinal resources and active ingredients within the genus.","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140442538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-21DOI: 10.25135/rnp.443.2312.2999
Baixiang Cai, Fan Xu, Xiaoyan Pan, Yin-zhong Fan, Bao-bao Shi, Jikai Liu
: A previously undescribed chromanol derivative, named currephila A ( 1 ), was isolated from the endophytic fungus Curreya pityophila , along with two known compounds ( 2 and 3 ). Their structures were elucidated based on spectroscopic methods, electronic circular dichroism, and spin−spin coupling constants. The cytotoxic activities of compounds 1 and 2 against human breast adenocarcinoma MCF-7 cells were evaluated.
{"title":"Currephila A, a New Chromanol Derivative from the Endophytic Fungus Curreya pityophila","authors":"Baixiang Cai, Fan Xu, Xiaoyan Pan, Yin-zhong Fan, Bao-bao Shi, Jikai Liu","doi":"10.25135/rnp.443.2312.2999","DOIUrl":"https://doi.org/10.25135/rnp.443.2312.2999","url":null,"abstract":": A previously undescribed chromanol derivative, named currephila A ( 1 ), was isolated from the endophytic fungus Curreya pityophila , along with two known compounds ( 2 and 3 ). Their structures were elucidated based on spectroscopic methods, electronic circular dichroism, and spin−spin coupling constants. The cytotoxic activities of compounds 1 and 2 against human breast adenocarcinoma MCF-7 cells were evaluated.","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140443227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-21DOI: 10.25135/rnp.445.2401.3018
Hao-Yang Geng, Wen-jie Gu, Jia-hui Luo, Yong-Xun Yang
: Ten sesquiterpenoids ( 1 - 10 ), including two new compounds 1 and 2 , were isolated with the use of several chromatographic methods from the above-ground tissues of Eupatorium adenophorum Spreng. Comprehensive spectroscopic studies, such as single-crystal X-ray diffraction, 1D, 2D-NMR, and HRMS, were used to characterize their structures. The cytotoxic and anti-inflammatory actions and properties of the new compounds 1 and 2 were examined and briefly discussed.
{"title":"Identification of Diverse Sesquiterpenoids from Eupatorium adenophorum","authors":"Hao-Yang Geng, Wen-jie Gu, Jia-hui Luo, Yong-Xun Yang","doi":"10.25135/rnp.445.2401.3018","DOIUrl":"https://doi.org/10.25135/rnp.445.2401.3018","url":null,"abstract":": Ten sesquiterpenoids ( 1 - 10 ), including two new compounds 1 and 2 , were isolated with the use of several chromatographic methods from the above-ground tissues of Eupatorium adenophorum Spreng. Comprehensive spectroscopic studies, such as single-crystal X-ray diffraction, 1D, 2D-NMR, and HRMS, were used to characterize their structures. The cytotoxic and anti-inflammatory actions and properties of the new compounds 1 and 2 were examined and briefly discussed.","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140443476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: A new diphenyl ether derivative, namely barceloneic lactone D ( 1 ), along with five known compounds ( 2-6 ) were isolated from the solid cultures of an endolichenic fungus, Preussia africana . The structure of new compound was elucidated by HR-ESI-MS, 1D and 2D NMR spectroscopy. All the isolates were evaluated for their antifungal activities. All compounds showed definite inhibitory activities with inhibition rate ranging from 9.2% to 79.2%.
{"title":"A New Diphenyl Ether Derivative from an Endolichenic Fungus, Preussia africana","authors":"Zhuang Li, Jinjie Liu, Miaomiao Xiong, Xinyi Zhai, Jinxiu Zhang, Jianhua Lv","doi":"10.25135/rnp.446-2401.3027","DOIUrl":"https://doi.org/10.25135/rnp.446-2401.3027","url":null,"abstract":": A new diphenyl ether derivative, namely barceloneic lactone D ( 1 ), along with five known compounds ( 2-6 ) were isolated from the solid cultures of an endolichenic fungus, Preussia africana . The structure of new compound was elucidated by HR-ESI-MS, 1D and 2D NMR spectroscopy. All the isolates were evaluated for their antifungal activities. All compounds showed definite inhibitory activities with inhibition rate ranging from 9.2% to 79.2%.","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140444889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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