Pub Date : 2023-12-17DOI: 10.25135/rnp.422.2308.2878
Lin Ni, Lijun Zheng, Jiarui Fu, Shilin Liu, Lin Chen, Shasha Wu, Xiaoqian Wu, Wenqiang Yan
{"title":"Identification of the Genus Pleione Based on Fingerprinting and Determination of the Content of their Key Components","authors":"Lin Ni, Lijun Zheng, Jiarui Fu, Shilin Liu, Lin Chen, Shasha Wu, Xiaoqian Wu, Wenqiang Yan","doi":"10.25135/rnp.422.2308.2878","DOIUrl":"https://doi.org/10.25135/rnp.422.2308.2878","url":null,"abstract":"","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":"21 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138966312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-22DOI: 10.25135/rnp.401.2303.2720
Elizabeth Quintero-Rueda, S. A. Velandia, R. Ocazionez, E. Stashenko, P. Rondón-Villarreal
{"title":"Comparative Anti-dengue Activities of Ethanolic and Supercritical Extracts of Lippia origanoides Kunth: in-vitro and in-silico Analyses","authors":"Elizabeth Quintero-Rueda, S. A. Velandia, R. Ocazionez, E. Stashenko, P. Rondón-Villarreal","doi":"10.25135/rnp.401.2303.2720","DOIUrl":"https://doi.org/10.25135/rnp.401.2303.2720","url":null,"abstract":"","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44698193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-15DOI: 10.25135/rnp.409.2201.2328
Kuo Xu, Xinying Du, Runxiang Zhai, Huijiao Li, Xianjun Fu
{"title":"Phytochemical and Pharmacological Studies of Natural Saponins from Platycodon grandiflorum","authors":"Kuo Xu, Xinying Du, Runxiang Zhai, Huijiao Li, Xianjun Fu","doi":"10.25135/rnp.409.2201.2328","DOIUrl":"https://doi.org/10.25135/rnp.409.2201.2328","url":null,"abstract":"","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135065299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-15DOI: 10.25135/rnp.408.2307.2832
Hancheng Ren, Weiqiang Fei
: In the current study, a new lignan ( 1 ), named callignan, as well as two known ones ( 2 and 3 ), were obtained from the EtOAc extract of the leaves of Callicarpa kwangtungensis . The structure elucidation of 1 was conducted by detailed interpretation of the 1D and 2D NMR spectroscopic data. Optical rotation of compound 1 and ECD data revealed that the compound was a racemic compound. Compounds 1 − 3 showed moderate effects with IC 50 values of 46, 29, and 42 M on NO production in LPS-induced RAW 264.7 cell inflammation model.
{"title":"Callignan A, A New Neolignan from the Leaves of Callicarpa kwangtungensis","authors":"Hancheng Ren, Weiqiang Fei","doi":"10.25135/rnp.408.2307.2832","DOIUrl":"https://doi.org/10.25135/rnp.408.2307.2832","url":null,"abstract":": In the current study, a new lignan ( 1 ), named callignan, as well as two known ones ( 2 and 3 ), were obtained from the EtOAc extract of the leaves of Callicarpa kwangtungensis . The structure elucidation of 1 was conducted by detailed interpretation of the 1D and 2D NMR spectroscopic data. Optical rotation of compound 1 and ECD data revealed that the compound was a racemic compound. Compounds 1 − 3 showed moderate effects with IC 50 values of 46, 29, and 42 M on NO production in LPS-induced RAW 264.7 cell inflammation model.","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46130346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: Chemical examination of the rice solid fermented cultures of the fungus Penicillium pinophilum J70 isolated from the fresh leaves of Hypericum japonicum Thumb led to the isolation of one new polyketide, namely penioctadecatrienoic A ( 1 ), together with two known compounds ( 2 and 3 ). The structure of the new metabolite 1 was resolved on the basis of extensive spectroscopic analysis (NMR and HRESIMS data), in association with the modified Mosher's method for the absolute configurational assignment. All isolated metabolites were evaluated for their cytotoxic activity against ECA-109, the anti-inflammatory activity against NO production in lipopolysaccharides (LPS) stimulated RAW264.7 cells, and the antibacterial activity on Staphylococcus aureus ATCC 29213. As a result, compounds 1‒3 showed moderately anti-inflammatory effects with the inhibitory rates ranging from 44.5% to 60.7% at the concentration of 20 μ M. In addition, compound 1 exhibited weakly antibacterial effect with an MIC value of 32 µ g/mL.
{"title":"Penioctadecatrienoic A: A New Polyketide from Endophytic Fungus Penicillium pinophilum J70","authors":"Siwen Niu, Juan Wang, Jianlin He, Xin Liu, Bi-hong Hong, Miao-Ling Yu","doi":"10.25135/rnp.397.2304.2752","DOIUrl":"https://doi.org/10.25135/rnp.397.2304.2752","url":null,"abstract":": Chemical examination of the rice solid fermented cultures of the fungus Penicillium pinophilum J70 isolated from the fresh leaves of Hypericum japonicum Thumb led to the isolation of one new polyketide, namely penioctadecatrienoic A ( 1 ), together with two known compounds ( 2 and 3 ). The structure of the new metabolite 1 was resolved on the basis of extensive spectroscopic analysis (NMR and HRESIMS data), in association with the modified Mosher's method for the absolute configurational assignment. All isolated metabolites were evaluated for their cytotoxic activity against ECA-109, the anti-inflammatory activity against NO production in lipopolysaccharides (LPS) stimulated RAW264.7 cells, and the antibacterial activity on Staphylococcus aureus ATCC 29213. As a result, compounds 1‒3 showed moderately anti-inflammatory effects with the inhibitory rates ranging from 44.5% to 60.7% at the concentration of 20 μ M. In addition, compound 1 exhibited weakly antibacterial effect with an MIC value of 32 µ g/mL.","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44660916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-27DOI: 10.25135/rnp.406.2305.2779
I. Ogunwande, D. Dai, L. T. Huong, N. C. Trường, V. T. Dung, T. Q. Ngan, Nguyen Dinh Tuong
{"title":"Essential Oil Constituent, Antimicrobial Activity, and Mosquito Larvicidal Activity of Murraya glabra (Guillaumin) Swingle from Vietnam","authors":"I. Ogunwande, D. Dai, L. T. Huong, N. C. Trường, V. T. Dung, T. Q. Ngan, Nguyen Dinh Tuong","doi":"10.25135/rnp.406.2305.2779","DOIUrl":"https://doi.org/10.25135/rnp.406.2305.2779","url":null,"abstract":"","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49096546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-13DOI: 10.25135/rnp.404.2304.2761
Ebrar Inal, Ebru ÖZDEMİR NATH, Mahmoud Abudayyak, Şeyma Ulusoy, Hatice Akbal İnan, M. Çiçek, M. Kartal
: The essential oil (EO) compositions and chemotypes of the important ethnomedicinal plant Vitex agnus-castus L. flowers, leaves, and fruits collected from Türkiye (Balıkesir and İstanbul) were identified in the present study. Different parts of the V. agnus-castus EO’s in-vitro cytotoxic effects on the MCF-7 (human breast adenocarcinoma) and A549 (human lung carcinoma) human-origin cell lines were anaylzed in the current study. The composition of hydrodistiled EOs extracted from flowers, leaves, and fruits of V. agnus-castus were analyzed by GC–FID/MS. Monoterpene hydrocarbons and oxygenated monoterpene compounds were detected as the predominant component class of the V. agnus-castus . EOs extracted from Balıkesir region were defined as the “ α - pinene-1,8-cineole” chemotype, while EOs extracted from İstanbul region were defined as the “sabinene-1,8-cineole” chemotype. Sesquiterpene hydrocarbons constituted more than 20% of the compounds in the EOs extracted from the flowers. To the best of our knowledge, this study is the first to analyze the in-vitro cytotoxic effects of flowers. This study is also the first to show the in-vitro cytotoxic effects of fruit, the most commonly used part of the plant, EO on the MCF-7 cell line. Balıkesir region’s EOs were observed as more potent -especially the purple flower’s IC 50 is about 4.68 µg/mL on the MCF7 cell line-than İstanbul regions, which might be attributed to the higher amount of α -pinene, caryophyllene, and limonene content. Our results indicated that the V. agnus-castus EOs, which contain α -pinene, 1,8-cineole, caryophyllene, and limonene as major components, showed relatively high cytotoxic effects compared to the control groups on the MCF7 and A549 cell lines.
{"title":"Chemical Composition of Different Parts of the Vitex agnus-castus L. Essential Oils and Their In-Vitro Cytotoxic Activities","authors":"Ebrar Inal, Ebru ÖZDEMİR NATH, Mahmoud Abudayyak, Şeyma Ulusoy, Hatice Akbal İnan, M. Çiçek, M. Kartal","doi":"10.25135/rnp.404.2304.2761","DOIUrl":"https://doi.org/10.25135/rnp.404.2304.2761","url":null,"abstract":": The essential oil (EO) compositions and chemotypes of the important ethnomedicinal plant Vitex agnus-castus L. flowers, leaves, and fruits collected from Türkiye (Balıkesir and İstanbul) were identified in the present study. Different parts of the V. agnus-castus EO’s in-vitro cytotoxic effects on the MCF-7 (human breast adenocarcinoma) and A549 (human lung carcinoma) human-origin cell lines were anaylzed in the current study. The composition of hydrodistiled EOs extracted from flowers, leaves, and fruits of V. agnus-castus were analyzed by GC–FID/MS. Monoterpene hydrocarbons and oxygenated monoterpene compounds were detected as the predominant component class of the V. agnus-castus . EOs extracted from Balıkesir region were defined as the “ α - pinene-1,8-cineole” chemotype, while EOs extracted from İstanbul region were defined as the “sabinene-1,8-cineole” chemotype. Sesquiterpene hydrocarbons constituted more than 20% of the compounds in the EOs extracted from the flowers. To the best of our knowledge, this study is the first to analyze the in-vitro cytotoxic effects of flowers. This study is also the first to show the in-vitro cytotoxic effects of fruit, the most commonly used part of the plant, EO on the MCF-7 cell line. Balıkesir region’s EOs were observed as more potent -especially the purple flower’s IC 50 is about 4.68 µg/mL on the MCF7 cell line-than İstanbul regions, which might be attributed to the higher amount of α -pinene, caryophyllene, and limonene content. Our results indicated that the V. agnus-castus EOs, which contain α -pinene, 1,8-cineole, caryophyllene, and limonene as major components, showed relatively high cytotoxic effects compared to the control groups on the MCF7 and A549 cell lines.","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43806231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-11DOI: 10.25135/rnp.405.2304.2763
Jiang Yongjun, Zi-jun Chen, Yuhong Tian, Mingzhu Ma
: A new pyran-2-one derivative, Nocardiopyrone C ( 1 ), and three known compounds, Nocardiopyrone B ( 2 ), 1-hydroxy-4-methoxy-2-naphthoic acid ( 3 ), and 2-(aminocarbonyl)-phenylcarbamate ( 4 ) were identified from the marine-derived Nocardiopsis aegyptia ZSN1. The chemical structure of the novel compound ( 1 ) was ascertained as (7 R )-5-(methoxymethyl)-3-methyl-6-(pentan-2-yl)-2 H -pyran-2-one using HRESIMS data, spectroscopic data, and ECD calculations. All four isolated compounds displayed antimicrobial activity, with the new compound 1 having the same MIC value of 50.0 µ M against E. coli , S. aureus , and C. albicans .
从海洋来源的埃及诺卡opsis aegyptia ZSN1中鉴定出新的吡喃-2- 1衍生物Nocardiopyrone C(1)和三个已知化合物Nocardiopyrone B(2)、1-羟基-4-甲氧基-2-萘酸(3)和2-(氨基羰基)-苯氨基甲酸酯(4)。新化合物(1)的化学结构为(7r)-5-(甲氧基甲基)-3-甲基-6-(戊烷-2-基)-2 H -吡喃-2- 1。4个化合物均具有抗菌活性，其中新化合物1对大肠杆菌、金黄色葡萄球菌和白色念珠菌的MIC值相同，均为50.0µM。
{"title":"Nocardiopyrone C, a New Antimicrobial Pyran-2-one Derivative from a Marine-derived Actinomycete Strain Nocardiopsis aegyptia ZSN1","authors":"Jiang Yongjun, Zi-jun Chen, Yuhong Tian, Mingzhu Ma","doi":"10.25135/rnp.405.2304.2763","DOIUrl":"https://doi.org/10.25135/rnp.405.2304.2763","url":null,"abstract":": A new pyran-2-one derivative, Nocardiopyrone C ( 1 ), and three known compounds, Nocardiopyrone B ( 2 ), 1-hydroxy-4-methoxy-2-naphthoic acid ( 3 ), and 2-(aminocarbonyl)-phenylcarbamate ( 4 ) were identified from the marine-derived Nocardiopsis aegyptia ZSN1. The chemical structure of the novel compound ( 1 ) was ascertained as (7 R )-5-(methoxymethyl)-3-methyl-6-(pentan-2-yl)-2 H -pyran-2-one using HRESIMS data, spectroscopic data, and ECD calculations. All four isolated compounds displayed antimicrobial activity, with the new compound 1 having the same MIC value of 50.0 µ M against E. coli , S. aureus , and C. albicans .","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":"5 S1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41265665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-07DOI: 10.25135/rnp.403.2304.2765
Dongdong Zhang, Haonan Xu, Wei Wang, Xinzhu Li, Yu-ze Li, Yi Jiang, Xiaomei Song, Chong Deng
The genus Kadsura is an important part of traditional Chinese medicine, it has the functions of promoting wind, eliminating dampness, activating blood circulation. Modern pharmacological studies have shown that lignans are one of the main components to possess these medicinal effects. This review aimed to provide a systematic summary on the traditional use, phytochemistry, pharmacology, toxicology and other aspects of lignans in genus Kadsura. In this paper, we collected the relevant literature on Kadsura lignans from 1973 to the present, and isolated more than 337 lignans from this genus, including dibenzocyclooctadienes, aryltetralins, tetrahydrofurans, diarylbutanes, 7,8-secolignans, bisepoxylignans, neolignans, seco-dibenzocyclooctadienes, sesquilignan and coumarin-containing lignan. Previous pharmacological studies have shown that lignans of the genus Kadsura have antitumor, anti-inflammatory, antibacterial, anti-HIV, anti-platelet aggregation, immunomodulatory and antioxidant effects. In clinical practice, it is commonly used to treat Alzheimer's disease, inflammation and insomnia. Kadsura is an important part of the field of Chinese medicine and is widely used in traditional medicine. However, further clarification of its active ingredients and mechanism of action and the establishment of a complete quality standard system are needed in order to provide a scientific basis for in-depth studies of this genus.
{"title":"Traditional Use, Pharmacology and Toxicology of the Lignans in Genus Kadsura: A Systematic Review","authors":"Dongdong Zhang, Haonan Xu, Wei Wang, Xinzhu Li, Yu-ze Li, Yi Jiang, Xiaomei Song, Chong Deng","doi":"10.25135/rnp.403.2304.2765","DOIUrl":"https://doi.org/10.25135/rnp.403.2304.2765","url":null,"abstract":"The genus Kadsura is an important part of traditional Chinese medicine, it has the functions of promoting wind, eliminating dampness, activating blood circulation. Modern pharmacological studies have shown that lignans are one of the main components to possess these medicinal effects. This review aimed to provide a systematic summary on the traditional use, phytochemistry, pharmacology, toxicology and other aspects of lignans in genus Kadsura. In this paper, we collected the relevant literature on Kadsura lignans from 1973 to the present, and isolated more than 337 lignans from this genus, including dibenzocyclooctadienes, aryltetralins, tetrahydrofurans, diarylbutanes, 7,8-secolignans, bisepoxylignans, neolignans, seco-dibenzocyclooctadienes, sesquilignan and coumarin-containing lignan. Previous pharmacological studies have shown that lignans of the genus Kadsura have antitumor, anti-inflammatory, antibacterial, anti-HIV, anti-platelet aggregation, immunomodulatory and antioxidant effects. In clinical practice, it is commonly used to treat Alzheimer's disease, inflammation and insomnia. Kadsura is an important part of the field of Chinese medicine and is widely used in traditional medicine. However, further clarification of its active ingredients and mechanism of action and the establishment of a complete quality standard system are needed in order to provide a scientific basis for in-depth studies of this genus.","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49457344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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