Recent patents on biotechnology最新文献

{"title":"In vitro florigenesis with special reference to orchids- A Review.","authors":"S. Kaur","doi":"10.2174/1872208316666220415124439","DOIUrl":"https://doi.org/10.2174/1872208316666220415124439","url":null,"abstract":"BACKGROUND\u0000The orchids are popular as beautiful cut-flowers in floriculture trade world over. The current paper reviews factors affecting the in vitro flowering in orchid species.\u0000\u0000\u0000METHOD\u0000The phenomenon of in vitro flowering is advantageous as it shortens the breeding cycle, which is prolonged in the in vivo grown orchid species of commercial value. Certain genetic and biochemical mechanisms are involved at the time of onset of flowering in orchid plants. In the present endeavour, efforts have been made to initiate in vitro flowering in a terrestrial and epiphytic orchid species. Various phenomenon involved during transition of vegetative shoot apex into floral axis is also reviewed.\u0000\u0000\u0000RESULTS\u0000In vitro flowering was induced in Dendrobium nobile and Zeuxine strateumatica in Mitra medium supplemented with BAP at 0.5 in mgl-1.\u0000\u0000\u0000CONCLUSION\u0000In vitro flowering can be initiated by manipulating physical and chemical stimulus in the nutrient regime. The study would be helpful in better understanding the complex process of flowering in vitro as well as ex vitro.","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46043030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Amino acids, Phenols and Protein Hydrolysates as Biostimulants on Sustainable Crop Production and Alleviate Stresses.","authors":"M. H. Shahrajabian, Q. Cheng, Wenli Sun","doi":"10.2174/1872208316666220412133749","DOIUrl":"https://doi.org/10.2174/1872208316666220412133749","url":null,"abstract":"Biostimulants which contain substances or products including natural compounds, special formulation and microorganisms have gained a considerable attention as sustainable method for heavy metal detoxification, stimulate natural toxins, controlling diseases and pests, may increase both water and nutrient efficiency. Biostimulants are important products in modern agriculture which composed of different heterogenous classes of compounds with a broad spectrum of action to increase both qualitative and quantitative productions. Amino acids can be useful in stress defence, photosynthesis, increase nutrient uptake, pollination and fruit formation, precursors to hormones and growth parameters. Amino acids are considered as precursors and constituents of proteins, which are well-known for stimulation of cell growth. Because, they are the basic building blocks of proteins, amino acids are very important in plant growth, development and metabolite synthesis. One of the diverse, notable and the large group of secondary metabolites is phenolic compounds which have important function in regulation of the plants physiological activities, oxidation-reduction processes and photosynthesis. Protein hydrolysates contain amino acids and peptides which is one of the most important kinds of biostimulants. Protein hydrolysates have notable capability to increase crop performance, particularly under environmental stress conditions. This review article is aimed to introduce and found more about the roles of different types of biostimulants on plant growth and final yield production with considering sustainable agriculture.","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48741587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alzheimer's Disease: A Silent Pandemic - A Systematic Review on the Situation and Patent Landscape of the Diagnosis.","authors":"L. D. Goyzueta-Mamani, Miguel Angel Chávez-Fumagalli, Karla L. Alvarez-Fernandez, J. Aguilar-Pineda, Rita Nieto-Montesinos, G. Davila Del-Carpio, K. J. Vera-López, C. L. Lino Cardenas","doi":"10.2174/1872208316666220408114129","DOIUrl":"https://doi.org/10.2174/1872208316666220408114129","url":null,"abstract":"BACKGROUND\u0000Alzheimer's disease (AD) is characterized by cognitive impairment, tau protein deposits, and amyloid beta plaques. AD impacted 44 million people in 2016, and it is estimated to affect 100 million people by 2050. AD is disregarded as a pandemic compared with other diseases. To date, there is no effective treatment or diagnosis.\u0000\u0000\u0000OBJECTIVE\u0000We aimed to discuss the current tools used to diagnose COVID-19, to point out their potential to be adapted for AD diagnosis, and to review the landscape of existing patents in the AD field and future perspectives for AD diagnosis.\u0000\u0000\u0000METHOD\u0000We carried out a scientific screening following a research strategy in PubMed; Web of Science; the Derwent Innovation Index; the KCI-Korean Journal Database; SciELO; the Russian Science Citation index; and the CDerwent, EDerwent, and MDerwent index databases.\u0000\u0000\u0000RESULTS\u0000A total of 326 from 6,446 articles about AD and 376 from 4,595 articles about COVID-19 were analyzed. Of these, AD patents were focused on biomarkers and neuroimaging with no accurate, validated diagnostic methods, and only 7% of kit development patents were found. In comparison, COVID-19 patents were 60% about kit development for diagnosis; they are highly accurate and are now commercialized.\u0000\u0000\u0000CONCLUSION\u0000AD is still neglected and not recognized as a pandemic that affects the people and economies of all nations. There is a gap in the development of AD diagnostic tools that could be filled if the interest and effort that has been invested to tackle the COVID-19 emergency could also be applied for innovation.","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47014697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herd Immunity against Coronavirus: A Review.","authors":"S. Datta, A. Roy","doi":"10.2174/1872208316666220408113002","DOIUrl":"https://doi.org/10.2174/1872208316666220408113002","url":null,"abstract":"The severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has spread exponentially, leading to an alarming number of deaths worldwide. A devastating effect has been observed in susceptible populations. Our body's immune system plays a very important role in fighting against the diseases. The principle of herd immunity (also known as population immunity), which has found its way into science and has been in the limelight, is the most widely recognised among all. It is an indirect defence against infectious diseases when a community has gained immunity, either through vaccines or through prior infection. Herd immunity against COVID-19 must be achieved to reduce the transmission of disease and save lives. Therefore, this review provides a comprehension of the role of immunity, with a special emphasis on herd immunity against COVID-19, and the ways to attain herd immunity in India have also been discussed.","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43563973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronavirus-A Crippling Affliction to Humans.","authors":"Rimple Kaul, S. Devi","doi":"10.2174/1872208316666220404103033","DOIUrl":"https://doi.org/10.2174/1872208316666220404103033","url":null,"abstract":"Coronaviruses hold idiosyncratic morphological features and functionality. The members of this group have a remarkable capability of infecting both animals and humans. Inimitably, the replication of the RNA genome continues through the set of viral mRNA molecules. Coronaviruses received the least attention until 2003 since they caused only minor respiratory tract illnesses. However, this changed exclusively with the introduction of zoonotic SARS-CoV in 2003. In 2012, MERS-CoV emerged and confirmed this group of viruses as the major causative agents of severe respiratory tract illness. Today, Coronavirus Disease 2019 (i.e., COVID-19) has turned out to be a chief health problem that causes a severe acute respiratory disorder in humans. Since the first identification of COVID-19 in December 2019 in Wuhan, China, this infection has devastatingly spread all around the globe leading to a crippling affliction for humans. The strain is known as the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), and WHO (the World Health Organization) has termed this new pandemic disease as Coronavirus Disease (COVID-19). COVID-19 is still spreading, with an estimated 136 million confirmed cases and more than 2.94 million deaths worldwide so far while the pandemic is still going on. In the current scenario, there is no particular treatment for COVID-19, however remarkable efforts for immunization and vaccine development can be observed. Therefore, the execution of precautions and proper preventive measures are indispensable to minimize and control the community transmission of the virus. This review summarizes information about the pathophysiology, transmission, symptoms, and the host defense mechanism as well as immunization and vaccine development against COVID-19.","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42392132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meet the Editorial Board Member","authors":"E. Jirillo","doi":"10.2174/187220831601220408113712","DOIUrl":"https://doi.org/10.2174/187220831601220408113712","url":null,"abstract":"Emilio Jirillo has been a full professor of immunology at the University of Bari Medical School (Bari, Italy) since 1986. His current fields of interest are mucosal immunity, microbial immunity, and immunonutrition. Especially in the field of immunonutrition, he has recently published in vitro and in vivo studies on the anti-inflammatory effects of polyphenols. He is the author of more than 560 papers, among which, 326 scientific papers are listed in PUBMED, including complete books and some chapters of books. He is the editor-in-chiefof Clinical Immunology Endocrine Metabolic Drugs and Endocrine Metabolic Immune Disorders-Drug Targets.","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41509229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence and Updates on non-dairy synbiotic beverage development.","authors":"Rhaissa Coelho Andrade, Caroline Santana Figueredo, Janaína de Carvalho Alves, M. N. Roselino","doi":"10.2174/1872208316666220303095807","DOIUrl":"https://doi.org/10.2174/1872208316666220303095807","url":null,"abstract":"BACKGROUND\u0000With the increase in cases of intolerance and allergies to milk protein, new food possibilities have been studied as an alternative to dairy drinks in order to meet the needs of this population, such as, non-dairy synbiotic drinks.\u0000\u0000\u0000OBJECTIVE\u0000The aim of this study was to carry out an integrative literature review on the main types of non-dairy synbiotic beverages, in order to investigate the probiotics and prebiotics added to them. Besides, we also looked into the characteristics of the substrates and fermentation conditions (temperature, time and pH), to assess the influences on bacterial viability, consumer acceptance, conservation and antimicrobial action.\u0000\u0000\u0000METHODS\u0000We conducted an integrative review of articles published on Pubmed, Web of Science, Scielo, Scopus and Capes journal in the last five years, using the following terms: symbiotic drink, symbiotic beverage, synbiotic drink, synbiotic beverage, bebida simbiótica, not kombucha, which after reading, resulted in the inclusion of 28 articles.\u0000\u0000\u0000RESULTS\u0000As expected, the main probiotics used were from the genera Lactobacillus and Bifidobacterium, and the prebiotics were inulin and fructooligosaccharide. It is noteworthy that all analyzed beverages were in fact probiotics since they obtained values above the minimum viability of 6 log CFU / mL, consequently, they can bring benefits to consumers.\u0000\u0000\u0000CONCLUSION\u0000Thus, beyond fruits and vegetables being rich sources of nutrients, they also enable the development of synbiotic drinks delivered from their substrates, being an alternative for the public with restrictions to milk.","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45997925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of patent information to characterize trends in the therapeutic applications of extracellular vesicles derived from mesenchymal stem cells (MSC-EVs).","authors":"Ángela Ponce-Polo, Alvaro RitoréHidalgo, Arturo Argüello Martínez, Roke Iñaki Oruezabal Guijarro","doi":"10.2174/1872208316666220303095217","DOIUrl":"https://doi.org/10.2174/1872208316666220303095217","url":null,"abstract":"Extracellular vesicles derived from mesenchymal stromal cells (MSC-EVs) are gaining interest for medical purposes. The promising therapeutic effects exhibited in both preclinical and clinical studies suggest that they may become an alternative for certain applications to cell-based therapies, which are subjected to stricter regulations. The commercial exploitation of these candidates requires a proper patent strategy from both the industry and public research organizations. Here, we raise a global patent literature analysis to identify key players and therapeutic applications in the field. Our results show an increasing rate of patent publications since 2009, with Asia (specifically China) leading the patenting activity. The therapeutic use of MSC-EVs within patent literature covers a wide range of diseases, in which \"Dermal and Wounds\", \"Neurology\" and \"Cardiovascular\" are the main therapeutic areas. Moreover, most of these patents include \"product-by-process\" claims, since the therapeutic effects of MSC-EVs could be influenced by their manufacturing process. Our results follow scientific and clinical literature trends.","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47944454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges and approaches of drugs such as Memantine, Donepezil, Rivastigmine and Aducanumab in the treatment, control and management of Alzheimer's disease.","authors":"Mohammad Saeedi, F. Mehranfar","doi":"10.2174/1872208316666220302115901","DOIUrl":"https://doi.org/10.2174/1872208316666220302115901","url":null,"abstract":"Alzheimer's disease (AD) is a kinds of neuropsychiatric illnesses that affect the central nervous system. In this disease, the accumulation of amyloid-beta increases, and phosphorylated tau (P-tau) protein, one of the ways to treat this disease is to reduce the accumulation of amyloid-beta. Various studies have demonstrated that pharmacological approaches have considerable effects in the treatment of AD, despite the side effects and challenges. Cholinesterase inhibitors and the NMDA receptor antagonist memantine are presently authorized therapies for AD. Memantine and Donepezil are the most common drugs for the prevention and therapy of AD with mechanisms such as lessened β-amyloid plaque, effect on N-Methyl-D-aspartate (NMDA) receptors. Diminution glutamate and elevated acetylcholine are some of the influences of medications administrated to treat AD, and drugs can also play a role in slowing the progression of cognitive and memory impairment. A new pharmacological approach and strategy is required to control the future of AD. This review appraises the effects of memantine, donepezil, rivastigmine, and aducanumab in clinical trials, in vitro and animal model studies that have explored how these drugs versus AD development and also discuss possible mechanisms of influence on the brain. Research in clinical trials has substantial findings that support the role of these medications in AD treatment and ameliorate the safety and efficacy of AD therapy, although more clinical trials are required to prove their effectiveness.","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47012328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into Novel Coronavirus Disease 2019 (COVID-19): Current Understanding, Research, and Therapeutic Updates.","authors":"Dudala Sai Sushma,&nbsp;Varun Jaiswal,&nbsp;Arvind Kumar,&nbsp;Syed Asha,&nbsp;Tarun Pal","doi":"10.2174/1872208315666210805152122","DOIUrl":"https://doi.org/10.2174/1872208315666210805152122","url":null,"abstract":"<p><strong>Background: </strong>Humans can be infected with various coronaviruses that can cause serious illness and death. One such pandemic strain of coronavirus was recently identified in December 2019, and it led to a devastating outbreak in Wuhan city of China. It is caused by severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2). It is highly contagious and causes symptoms such as fever, cough, and shortness of breath.</p><p><strong>Objective: </strong>The objective of this review is to highlight the current understanding, research, and therapeutic updates of the novel coronavirus disease 2019 (COVID-19).</p><p><strong>Methods: </strong>A thorough literature search was conducted for research papers and patents in the context of COVID-19. All the related articles were extracted from various public repositories such as Google Scholar, Pubmed, ScienceDirect (Elsevier), Springer, Web of Science, etc. Results: The present analysis revealed that the key areas of the inventions were vaccines and diagnostic kits apart from developing the treatment of CoV. It was also observed that no specific vaccine treatments were available for the treatment of 2019-nCov; therefore, developing novel chemical or biological drugs and kits for early diagnosis, prevention, and disease management is the primary governing topic among the patented inventions. The present study also indicates potential research opportunities for the future, particularly to combat 2019-nCoV. The current focus of the researches has turned towards developing four potential treatments, including the development of candidate vaccines, development of novel potential drugs, repurposing of existing drugs, and development of convalescent plasma therapy. The PCR based diagnosis is the gold standard for the COVID-19 testing, but it requires resource time, expertise, and high associated cost; hence researchers are also developing different diagnostic methods for the COVID-19. Although vaccines are being developed by various companies and have passed the pre-clinical stages but there still exists no guarantee for these to come into effect. The current treatments that are being used for COVID-19 patients are not well established and have shown limited success.</p><p><strong>Conclusion: </strong>The pandemic has challenged the medical, economic, and public health infrastructure across the globe. There is an urgent need to explore all available and possible methods/ approaches to study this disease for drug and vaccine development at the earliest.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":"16 1","pages":"35-63"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39279210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}