Pub Date : 2024-03-27DOI: 10.2174/0118722083287672240321081428
S. Mirza, Sidra Akbar, Muhammad Umer Ijaz, Mohammad Hossein Morowvat, Ayesha Ishaque, Kalsoom Fatima
The marine environment is one of the major biomass producers of algae and seaweed; it is rich in functional ingredients or active metabolites with valuable nutritional health effects. Algal Metabolites derived from the cultivation of both microalgae and macroalgae may positively impact human health, offering physiological, pharmaceutical and nutritional benefits. Microalgae have been widely used as novel sources of bioactive substances. Bioactive polymers extracted from algae, such as algal fucans, Galatians, alginates phenolics, carotenoids, vitamin B12, and peptides possess antioxidant, anticoagulant, antimicrobial, antiviral, anti-inflammatory, anti-allergy, anticancer, and hypocholesterolemic properties. It emphasizes that using marine-derived compounds with bioactive properties as functional food ingredients may help promote human health and prevent chronic diseases. Utilizing bioactive compounds has demonstrated notable advantages in terms of effectiveness more than conventional treatments and therapies currently in use. Despite the availability of numerous microalgae-derived products catering to human health and nutrition in the market, there remains a lack of social acceptance and awareness regarding the health benefits of microalgae. Hence, this review aims to offer a comprehensive account of the current knowledge on anticancers, antioxidants, commercially available edible algal products and therapeutics isolated from algae.
{"title":"Nutritional Health Connection of Algae and its Pharmaceutical Value as Anticancer and Antioxidant Constituents of Drugs","authors":"S. Mirza, Sidra Akbar, Muhammad Umer Ijaz, Mohammad Hossein Morowvat, Ayesha Ishaque, Kalsoom Fatima","doi":"10.2174/0118722083287672240321081428","DOIUrl":"https://doi.org/10.2174/0118722083287672240321081428","url":null,"abstract":"\u0000\u0000The marine environment is one of the major biomass producers of algae and\u0000seaweed; it is rich in functional ingredients or active metabolites with valuable nutritional\u0000health effects. Algal Metabolites derived from the cultivation of both microalgae and\u0000macroalgae may positively impact human health, offering physiological, pharmaceutical\u0000and nutritional benefits. Microalgae have been widely used as novel sources of bioactive\u0000substances. Bioactive polymers extracted from algae, such as algal fucans, Galatians, alginates\u0000phenolics, carotenoids, vitamin B12, and peptides possess antioxidant, anticoagulant,\u0000antimicrobial, antiviral, anti-inflammatory, anti-allergy, anticancer, and hypocholesterolemic\u0000properties. It emphasizes that using marine-derived compounds with bioactive\u0000properties as functional food ingredients may help promote human health and prevent\u0000chronic diseases. Utilizing bioactive compounds has demonstrated notable advantages in\u0000terms of effectiveness more than conventional treatments and therapies currently in use.\u0000Despite the availability of numerous microalgae-derived products catering to human\u0000health and nutrition in the market, there remains a lack of social acceptance and awareness\u0000regarding the health benefits of microalgae. Hence, this review aims to offer a comprehensive\u0000account of the current knowledge on anticancers, antioxidants, commercially\u0000available edible algal products and therapeutics isolated from algae.\u0000","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":"24 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140375069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-21DOI: 10.2174/0118722083297406240313090140
P. Singh, Kapil Sachan, Vishal Khandelwal, Sumita Singh, Smita Singh
Traditional drug discovery methods such as wet-lab testing, validations, and synthetic techniques are time-consuming and expensive. Artificial Intelligence (AI) approaches have progressed to the point where they can have a significant impact on the drug discovery process. Using massive volumes of open data, artificial intelligence methods are revolutionizing the pharmaceutical industry. In the last few decades, many AI-based models have been developed and implemented in many areas of the drug development process. These models have been used as a supplement to conventional research to uncover superior pharmaceuticals expeditiously. Drug research and development to repurposing and productivity benefits in the pharmaceutical business through clinical trials. AI is studied in this article for its numerous potential uses. We have discussed how AI can be put to use in the pharmaceutical sector, specifically for predicting a drug's toxicity, bioactivity, and physicochemical characteristics, among other things. In this review article, we have discussed its application to a variety of problems, including de novo drug discovery, target structure prediction, interaction prediction, and binding affinity prediction. AI for predicting drug interactions and nanomedicines were also considered.
{"title":"Role of Artificial Intelligence in Drug Discovery to Revolutionize\u0000the Pharmaceutical Industry: Resources, Methods and Applications","authors":"P. Singh, Kapil Sachan, Vishal Khandelwal, Sumita Singh, Smita Singh","doi":"10.2174/0118722083297406240313090140","DOIUrl":"https://doi.org/10.2174/0118722083297406240313090140","url":null,"abstract":"\u0000\u0000Traditional drug discovery methods such as wet-lab testing, validations, and\u0000synthetic techniques are time-consuming and expensive. Artificial Intelligence (AI) approaches\u0000have progressed to the point where they can have a significant impact on the\u0000drug discovery process. Using massive volumes of open data, artificial intelligence\u0000methods are revolutionizing the pharmaceutical industry. In the last few decades, many\u0000AI-based models have been developed and implemented in many areas of the drug development\u0000process. These models have been used as a supplement to conventional research\u0000to uncover superior pharmaceuticals expeditiously. Drug research and development\u0000to repurposing and productivity benefits in the pharmaceutical business through\u0000clinical trials. AI is studied in this article for its numerous potential uses. We have discussed\u0000how AI can be put to use in the pharmaceutical sector, specifically for predicting a\u0000drug's toxicity, bioactivity, and physicochemical characteristics, among other things. In\u0000this review article, we have discussed its application to a variety of problems, including\u0000de novo drug discovery, target structure prediction, interaction prediction, and binding affinity\u0000prediction. AI for predicting drug interactions and nanomedicines were also considered.\u0000","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":" 38","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140388110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}