Pub Date : 2023-12-01DOI: 10.1134/s263482762460004x
Abstract―
This work generalizes methods for preparation of basic platform compounds, namely, hem-dichlorocyclopropanes and 1,3-dioxacycloalkanes with various substituents. On their basis, the synthesis of carbo- and heterocyclic compounds is carried out, which have herbicidal, cytotoxic, anticoagulant and antiaggregation properties and are of interest in terms of creating new pesticides for dicotyledonous and monocotyledonous plants, drugs that prevent blood clotting or inhibit the development of tumor cells.
{"title":"Preparation of Substituted gem-Dichlorocyclopropanes and 1,3-Dioxacycloalkanes and Their Biological Activity: A Review","authors":"","doi":"10.1134/s263482762460004x","DOIUrl":"https://doi.org/10.1134/s263482762460004x","url":null,"abstract":"<span> <h3>Abstract―</h3> <p>This work generalizes methods for preparation of basic platform compounds, namely, hem-dichlorocyclopropanes and 1,3-dioxacycloalkanes with various substituents. On their basis, the synthesis of carbo- and heterocyclic compounds is carried out, which have herbicidal, cytotoxic, anticoagulant and antiaggregation properties and are of interest in terms of creating new pesticides for dicotyledonous and monocotyledonous plants, drugs that prevent blood clotting or inhibit the development of tumor cells.</p> </span>","PeriodicalId":21086,"journal":{"name":"Reviews and Advances in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140167584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.1134/s263482762360024x
Abstract
Direct transition-metal free bond activation and bond formation reaction are central to the development of a sustainable and effective strategy for the synthesis of organic molecules. Facile, aerobic, regiospecific, base-mediated transition metal-free, and direct arylation reactions with inexpensive nitroarenes are need to explore. The use of strong base, promotes the vicarious nucleophilic substitution in nitroarenes. Moreover, functional group modification of synthesized nitroarenes compounds can open myriad applications in pharmaceutical and material industries. In this review, we summarize the recent progress achieved in the transition metal-free, base-mediated methodology has been employed for mono arylation, di-arylation, acylation, and aroylation reactions and we cover the research literature from 2013 to 2022. This review article presents the advantages, limitations, mechanistic rationalization, and future perspectives associated with synthetic methodologies.
{"title":"Base-mediated Transition-metal Free Regiospecific Substitution with Nitroarenes: Vicarious Nucleophilic Substitution of Hydrogen in Nitroarenes","authors":"","doi":"10.1134/s263482762360024x","DOIUrl":"https://doi.org/10.1134/s263482762360024x","url":null,"abstract":"<span> <h3>Abstract</h3> <p>Direct transition-metal free bond activation and bond formation reaction are central to the development of a sustainable and effective strategy for the synthesis of organic molecules. Facile, aerobic, regiospecific, base-mediated transition metal-free, and direct arylation reactions with inexpensive nitroarenes are need to explore. The use of strong base, promotes the vicarious nucleophilic substitution in nitroarenes. Moreover, functional group modification of synthesized nitroarenes compounds can open myriad applications in pharmaceutical and material industries. In this review, we summarize the recent progress achieved in the transition metal-free, base-mediated methodology has been employed for mono arylation, di-arylation, acylation, and aroylation reactions and we cover the research literature from 2013 to 2022. This review article presents the advantages, limitations, mechanistic rationalization, and future perspectives associated with synthetic methodologies.</p> </span>","PeriodicalId":21086,"journal":{"name":"Reviews and Advances in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140167463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.1134/s2634827624600038
Abstract―
An overview of the specific toxicity of nanoparticles as of 2023 is provided. The methods of synthesis, structure and properties of synthetic and anthropogenic inorganic nanoparticles are generalized; the state of the surface and the structuring effect that determine their specific toxicity are discussed. The use of nanoparticles in cosmetology and medicine, as well as the influence of nanoparticles of anthropogenic origin on technosphere safety, is considered.
{"title":"Specific Toxicity of Nanoparticles: A Review","authors":"","doi":"10.1134/s2634827624600038","DOIUrl":"https://doi.org/10.1134/s2634827624600038","url":null,"abstract":"<span> <h3>Abstract―</h3> <p>An overview of the specific toxicity of nanoparticles as of 2023 is provided. The methods of synthesis, structure and properties of synthetic and anthropogenic inorganic nanoparticles are generalized; the state of the surface and the structuring effect that determine their specific toxicity are discussed. The use of nanoparticles in cosmetology and medicine, as well as the influence of nanoparticles of anthropogenic origin on technosphere safety, is considered.</p> </span>","PeriodicalId":21086,"journal":{"name":"Reviews and Advances in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140167670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-24DOI: 10.1134/s263482762370023x
M. V. Buzaeva, I. A. Makarova, E. S. Vaganova, O. A. Davydova, Yu. I. Sud’in, V. A. Sergeev
Abstract
The work considers the processes of modifying the surface of multiwalled carbon nanotubes with various polar groups: carboxyl, alcoholic hydroxyl, and quaternary ammonium salt. A procedure is developed using an oxidizing mixture of hydrogen peroxide, nitric acid, and sulfuric acid for the carboxylation of carbon nanotubes at a temperature of 70°C, which minimizes the formation of amorphous carbon and increases the concentration of carboxyl groups on the surface to 5.5 wt %. Tubes with a surface modified with a quaternary ammonium salt are obtained from carboxylated carbon nanotubes by reaction with triethanolamine. The modification of carbon nanotubes with ethyl hydroxyl groups is carried out with the participation of a free-radical initiator in an ethanol medium. The initial defects of nanotubes determine the number and nature of the defects at which chemical bonding occurs during functionalization, regardless of the method of nanocarbon material processing. The thermal–oxidative stability of the initial and modified carbon nanotubes in air is explored. The initial nanotubes are the most stable; they maintain their properties even when heated up to 520°C in air. For modified nanotubes, the thermal stability decreases in the series multiwalled nanotubes with carboxyl groups on the surface, multiwalled nanotubes with alcoholic hydroxyl groups, and multiwalled nanotubes modified with a quaternary ammonium salt, the oxidation of which begins at 400°C. The grafting of alcohol hydroxyl groups onto the surface of multiwalled carbon nanotubes is of considerable interest for obtaining an adsorption material with a developed surface, capable of covalently binding metal ions due to hydroxyl groups, similarly to complexing agents such as ethylene glycol or pyrocatechol. Carbon nanomaterials modified with polar groups exhibit good adsorption properties with respect to heavy metal ions. The degree of extraction of zinc and copper ions in the case of carboxylated nanotubes reaches 98%.
{"title":"Surface Modification of Multiwalled Carbon Nanotubes to Impart Technological Properties","authors":"M. V. Buzaeva, I. A. Makarova, E. S. Vaganova, O. A. Davydova, Yu. I. Sud’in, V. A. Sergeev","doi":"10.1134/s263482762370023x","DOIUrl":"https://doi.org/10.1134/s263482762370023x","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>The work considers the processes of modifying the surface of multiwalled carbon nanotubes with various polar groups: carboxyl, alcoholic hydroxyl, and quaternary ammonium salt. A procedure is developed using an oxidizing mixture of hydrogen peroxide, nitric acid, and sulfuric acid for the carboxylation of carbon nanotubes at a temperature of 70°C, which minimizes the formation of amorphous carbon and increases the concentration of carboxyl groups on the surface to 5.5 wt %. Tubes with a surface modified with a quaternary ammonium salt are obtained from carboxylated carbon nanotubes by reaction with triethanolamine. The modification of carbon nanotubes with ethyl hydroxyl groups is carried out with the participation of a free-radical initiator in an ethanol medium. The initial defects of nanotubes determine the number and nature of the defects at which chemical bonding occurs during functionalization, regardless of the method of nanocarbon material processing. The thermal–oxidative stability of the initial and modified carbon nanotubes in air is explored. The initial nanotubes are the most stable; they maintain their properties even when heated up to 520°C in air. For modified nanotubes, the thermal stability decreases in the series multiwalled nanotubes with carboxyl groups on the surface, multiwalled nanotubes with alcoholic hydroxyl groups, and multiwalled nanotubes modified with a quaternary ammonium salt, the oxidation of which begins at 400°C. The grafting of alcohol hydroxyl groups onto the surface of multiwalled carbon nanotubes is of considerable interest for obtaining an adsorption material with a developed surface, capable of covalently binding metal ions due to hydroxyl groups, similarly to complexing agents such as ethylene glycol or pyrocatechol. Carbon nanomaterials modified with polar groups exhibit good adsorption properties with respect to heavy metal ions. The degree of extraction of zinc and copper ions in the case of carboxylated nanotubes reaches 98%.</p>","PeriodicalId":21086,"journal":{"name":"Reviews and Advances in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138537724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-24DOI: 10.1134/s2634827623700216
V. V. Sharutin, A. V. Rybakova
Abstract
This article is a systematic overview of the literature published predominantly between 2020 and 2023 focusing on the preparation methods, reactions, and structural characteristics of organoplatinum compounds featuring two or more platinum–carbon bonds. Additionally, examples illustrating their potential applications are highlighted. Special emphasis is placed on discussing the most effective synthetic approaches. The formation reactions of organic platinum compounds with multiple Pt–C bonds are explored, alongside insights into their catalytic and biological activities.
{"title":"Organoplatinum Compounds Containing at Least Two Platinum–Carbon Bonds: Synthesis, Structure, and Practical Applications","authors":"V. V. Sharutin, A. V. Rybakova","doi":"10.1134/s2634827623700216","DOIUrl":"https://doi.org/10.1134/s2634827623700216","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>This article is a systematic overview of the literature published predominantly between 2020 and 2023 focusing on the preparation methods, reactions, and structural characteristics of organoplatinum compounds featuring two or more platinum–carbon bonds. Additionally, examples illustrating their potential applications are highlighted. Special emphasis is placed on discussing the most effective synthetic approaches. The formation reactions of organic platinum compounds with multiple Pt–C bonds are explored, alongside insights into their catalytic and biological activities.</p>","PeriodicalId":21086,"journal":{"name":"Reviews and Advances in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138537731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-24DOI: 10.1134/s2634827623600056
Y. Puchkova, N. Sedush, E. Kuznetsova, A. Nazarov, S. Chvalun
Abstract
The present study investigates the effect of the length of the hydrophobic poly(D,L-lactide) block on the self-assembly behavior of amphiphilic poly(D,L-lactide)-b-poly(ethylene glycol) (P(D,L)LA-b-PEG5k) copolymers with a large variation in molecular weight of the hydrophobic block (ranging from 5 to 100 kDa). To evaluate the cytotoxic effect of oxaliplatin-loaded P(D,L)LA-b-PEG5k nanoparticles (OXA-NPs) prepared by the nanoprecipitation method, a half maximal inhibitory concentration (IC50) study was conducted in cancer cell lines (MCF7, HCT116, and A549). The assays revealed that the IC50 values for OXA-NPs in HCT116 (1.93 ± 0.08 nM) and A549 (2.84 ± 0.11 nM) were significantly lower than those of pure OXA (12.70 ± 1.14 and 29.30 ± 0.40 nM, respectively). Moreover, the results showed that normal fibroblasts treated with blank NPs exhibited no significant growth inhibition in the concentration range of 0.001–1 mg mL–1, indicating their high biocompatibility.
{"title":"Self-Assembly Behavior and Cytotoxicity of PEG-b-PLA Nanoparticles for Improved Oxaliplatin Delivery: Effect of PLA Block Length","authors":"Y. Puchkova, N. Sedush, E. Kuznetsova, A. Nazarov, S. Chvalun","doi":"10.1134/s2634827623600056","DOIUrl":"https://doi.org/10.1134/s2634827623600056","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>The present study investigates the effect of the length of the hydrophobic poly(D,L-lactide) block on the self-assembly behavior of amphiphilic poly(D,L-lactide)-<i>b</i>-poly(ethylene glycol) (P(D,L)LA-<i>b</i>-PEG<sub>5k</sub>) copolymers with a large variation in molecular weight of the hydrophobic block (ranging from 5 to 100 kDa). To evaluate the cytotoxic effect of oxaliplatin-loaded P(D,L)LA-<i>b</i>-PEG<sub>5k</sub> nanoparticles (OXA-NPs) prepared by the nanoprecipitation method, a half maximal inhibitory concentration (IC<sub>50</sub>) study was conducted in cancer cell lines (MCF7, HCT116, and A549). The assays revealed that the IC<sub>50</sub> values for OXA-NPs in HCT116 (1.93 ± 0.08 nM) and A549 (2.84 ± 0.11 nM) were significantly lower than those of pure OXA (12.70 ± 1.14 and 29.30 ± 0.40 nM, respectively). Moreover, the results showed that normal fibroblasts treated with blank NPs exhibited no significant growth inhibition in the concentration range of 0.001–1 mg mL<sup>–1</sup>, indicating their high biocompatibility<i>.</i></p>","PeriodicalId":21086,"journal":{"name":"Reviews and Advances in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138537748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-24DOI: 10.1134/s2634827623700228
V. V. Sharutin, A. R. Zykova
Abstract—
Since the discovery of a platinum compound containing the organic ethylene ligand by William Zeise in 1827, organic platinum compounds have attracted the attention of scientists all over the world. With the discovery of new properties of platinum compounds, the areas of their application have expanded: from catalysts of chemical reactions to use in medicine in the treatment of malignant tumors. This review analyzes the methods of synthesis, structural features, and the possibility of their practical use, published from 2020 to 2023. Due to the large amount of literature data on this topic, this review attempts to piece together and systematize the methods of synthesis and properties of organic platinum compounds containing one platinum–carbon bond in their composition. The main tendencies and directions of research into organic platinum compounds are revealed. The most efficient methods of synthesis, the chemical properties, and some reaction mechanisms are presented. Information on biological activity and catalytic and photoluminescent properties is presented.
{"title":"Synthesis and Reactivity of Organometallic Platinum Compounds containing one platinum–carbon bond","authors":"V. V. Sharutin, A. R. Zykova","doi":"10.1134/s2634827623700228","DOIUrl":"https://doi.org/10.1134/s2634827623700228","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract—</h3><p>Since the discovery of a platinum compound containing the organic ethylene ligand by William Zeise in 1827, organic platinum compounds have attracted the attention of scientists all over the world. With the discovery of new properties of platinum compounds, the areas of their application have expanded: from catalysts of chemical reactions to use in medicine in the treatment of malignant tumors. This review analyzes the methods of synthesis, structural features, and the possibility of their practical use, published from 2020 to 2023. Due to the large amount of literature data on this topic, this review attempts to piece together and systematize the methods of synthesis and properties of organic platinum compounds containing one platinum–carbon bond in their composition. The main tendencies and directions of research into organic platinum compounds are revealed. The most efficient methods of synthesis, the chemical properties, and some reaction mechanisms are presented. Information on biological activity and catalytic and photoluminescent properties is presented.</p>","PeriodicalId":21086,"journal":{"name":"Reviews and Advances in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138537749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.1134/s2634827623600172
Abstract
Methods of obtaining, some reactions, and structural features of platinum nitrile complexes are systematized and described based on an analysis of literature primarily published from 2020 to 2023. The discussion of synthesis methods is primarily focused on the most effective approaches. The formation reactions of platinum nitrile complexes and some of their structural characteristics are examined.
{"title":"Platinum Nitrile Complexes. Synthesis and Structure","authors":"","doi":"10.1134/s2634827623600172","DOIUrl":"https://doi.org/10.1134/s2634827623600172","url":null,"abstract":"<span> <h3>Abstract</h3> <p>Methods of obtaining, some reactions, and structural features of platinum nitrile complexes are systematized and described based on an analysis of literature primarily published from 2020 to 2023. The discussion of synthesis methods is primarily focused on the most effective approaches. The formation reactions of platinum nitrile complexes and some of their structural characteristics are examined<em>.</em></p> </span>","PeriodicalId":21086,"journal":{"name":"Reviews and Advances in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140007465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.1134/S2634827623700198
A. Kovalev, D. Vinnik, D. Zherebtsov, E. A. Belaya
{"title":"Sol–Gel Synthesis of Nanodispersed Solid Solutions Based on SrxBa(1 –x)Fe12O19 Barium Hexaferrite","authors":"A. Kovalev, D. Vinnik, D. Zherebtsov, E. A. Belaya","doi":"10.1134/S2634827623700198","DOIUrl":"https://doi.org/10.1134/S2634827623700198","url":null,"abstract":"","PeriodicalId":21086,"journal":{"name":"Reviews and Advances in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75326816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.1134/S2634827623700204
A. Rybakova, D. Kim, V. Sharutin, P. Slepukhin
{"title":"Synthesis and Electrophilic Heterocyclization of 3-Alkenylsulfanyl-5-phenyl-1,2,4-triazines under the Action of Iodine and Bromine","authors":"A. Rybakova, D. Kim, V. Sharutin, P. Slepukhin","doi":"10.1134/S2634827623700204","DOIUrl":"https://doi.org/10.1134/S2634827623700204","url":null,"abstract":"","PeriodicalId":21086,"journal":{"name":"Reviews and Advances in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74943751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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