Mohammad Amirul Islam, Shaiful Kabir, Ali Arman, Untung Sugiharto, M. Moinul Islam, Mohammad Belal Hossen
In this study, alpha spectrometry and neutron activation analysis were applied to assess the mass accumulation rate, contamination history, and ecological risk of the Sundarban mangrove sediments. The mass accumulation rates of sediments using 210Pb dating determined for the first time in this area ranged from 0.068 to 3.20 kg m−2 y−1, with an average of 0.61 kg m−2 y−1. The contamination history of 11 metal(loid)s (Al, Ca, V, Cr, Fe, Ni, Cu, Zn, As, Hg, and Pb) was assessed. Different environmental contamination indices suggested that Sundarban mangrove sediments were contaminated by As. Considering different sediment quality guidelines, it was observed that Cr, Ni, and As posed occasional adverse biological effects on marine organisms. Multivariate statistical approaches were applied to elucidate the origin and transport behavior of the studied metal(loid)s in the mangrove ecosystem which suggested that sources of metal(loid) pollution were both anthropogenic and geogenic. The results from this study should improve the knowledge of metal contamination and ecological risk to biota to develop new strategies and enlarge management practices to save sensitive mangrove ecosystems.
本研究采用阿尔法光谱法和中子活化分析来评估巽他班红树林沉积物的质量累积率、污染历史和生态风险。利用 210Pb 测定法首次测定了该地区沉积物的质量累积率，其范围为 0.068 至 3.20 kg m-2 y-1，平均为 0.61 kg m-2 y-1。对 11 种金属（Al、Ca、V、Cr、Fe、Ni、Cu、Zn、As、Hg 和 Pb）的污染历史进行了评估。不同的环境污染指数表明，圣达班红树林沉积物受到砷的污染。根据不同的沉积物质量标准，铬、镍和砷偶尔会对海洋生物造成不利的生物影响。应用多元统计方法阐明了所研究的金属（loid）在红树林生态系统中的来源和迁移行为，表明金属（loid）污染源既有人为的，也有地质的。这项研究的结果应能提高人们对金属污染和生物群生态风险的认识，从而制定新的策略和扩大管理实践，拯救敏感的红树林生态系统。
{"title":"210Pb dating and neutron activation analysis of the Sundarban mangrove sediments: sedimentation rate and metal contamination history","authors":"Mohammad Amirul Islam, Shaiful Kabir, Ali Arman, Untung Sugiharto, M. Moinul Islam, Mohammad Belal Hossen","doi":"10.1515/ract-2023-0245","DOIUrl":"https://doi.org/10.1515/ract-2023-0245","url":null,"abstract":"In this study, alpha spectrometry and neutron activation analysis were applied to assess the mass accumulation rate, contamination history, and ecological risk of the Sundarban mangrove sediments. The mass accumulation rates of sediments using <jats:sup>210</jats:sup>Pb dating determined for the first time in this area ranged from 0.068 to 3.20 kg m<jats:sup>−2</jats:sup> y<jats:sup>−1</jats:sup>, with an average of 0.61 kg m<jats:sup>−2</jats:sup> y<jats:sup>−1</jats:sup>. The contamination history of 11 metal(loid)s (Al, Ca, V, Cr, Fe, Ni, Cu, Zn, As, Hg, and Pb) was assessed. Different environmental contamination indices suggested that Sundarban mangrove sediments were contaminated by As. Considering different sediment quality guidelines, it was observed that Cr, Ni, and As posed occasional adverse biological effects on marine organisms. Multivariate statistical approaches were applied to elucidate the origin and transport behavior of the studied metal(loid)s in the mangrove ecosystem which suggested that sources of metal(loid) pollution were both anthropogenic and geogenic. The results from this study should improve the knowledge of metal contamination and ecological risk to biota to develop new strategies and enlarge management practices to save sensitive mangrove ecosystems.","PeriodicalId":21167,"journal":{"name":"Radiochimica Acta","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139759120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Chattopadhyay, Samarjit Singha, Shayantani Ash, Luna Barua, Devaraj G. Mahesh, Sujata SahaDas, Madhusmita, Md. Nayer Alam, Umesh Kumar, Suprakash Roy, Prosenjit Dhang, S. Dey
Gallium-68 [t 1/2: 67.7 min, β+ (89 %)] has application in PET imaging mainly for prostate cancer and neuroendocrine tumours. Gallium-68 is generally obtained from a 68Ge/68Ga generator. It is therefore an important task to prepare 68Ge (t 1/2 = 271 days) radiochemical for the manufacture of 68Ge/68Ga generator to cater for the needs of various nuclear medicine centres. Germanium-68 has been produced successfully after irradiation of indigenously developed Ga–Ni targets in a 30 MeV cyclotron and chemical processing of the irradiated targets using an indigenous semi-automated module. The Ga–Ni targets were prepared by an electroplating method. The 68Ge has been radiochemically separated from irradiated Ga–Ni targets using Sephadex G-25 column chromatography. The chemical separation yield and radionuclidic purity of 68Ge were about 70 % (n = 3) and about 98.3 % (n = 3), respectively.
{"title":"Production and radiochemical separation of 68Ge from irradiated Ga–Ni alloy target in 30 MeV cyclotron","authors":"S. Chattopadhyay, Samarjit Singha, Shayantani Ash, Luna Barua, Devaraj G. Mahesh, Sujata SahaDas, Madhusmita, Md. Nayer Alam, Umesh Kumar, Suprakash Roy, Prosenjit Dhang, S. Dey","doi":"10.1515/ract-2023-0195","DOIUrl":"https://doi.org/10.1515/ract-2023-0195","url":null,"abstract":"\u0000 Gallium-68 [t\u0000 1/2: 67.7 min, β+ (89 %)] has application in PET imaging mainly for prostate cancer and neuroendocrine tumours. Gallium-68 is generally obtained from a 68Ge/68Ga generator. It is therefore an important task to prepare 68Ge (t\u0000 1/2 = 271 days) radiochemical for the manufacture of 68Ge/68Ga generator to cater for the needs of various nuclear medicine centres. Germanium-68 has been produced successfully after irradiation of indigenously developed Ga–Ni targets in a 30 MeV cyclotron and chemical processing of the irradiated targets using an indigenous semi-automated module. The Ga–Ni targets were prepared by an electroplating method. The 68Ge has been radiochemically separated from irradiated Ga–Ni targets using Sephadex G-25 column chromatography. The chemical separation yield and radionuclidic purity of 68Ge were about 70 % (n = 3) and about 98.3 % (n = 3), respectively.","PeriodicalId":21167,"journal":{"name":"Radiochimica Acta","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139777329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arvind Prasad, Kadukkappilly S. Vijayan, Ravinuthala V. S. Rao, Desigan Narasimhan, Ananthasivan Krishnamoorty
Plutonium oxalate supernatant requires a treatment step for further recovery of the residual Pu. As the oxalate ion present in the solution poses problems during the recovery of Pu, it needs to be destroyed. In the present work, Mn2+ based catalytic destruction of oxalate ion was studied in detail, as it could minimize the generation of secondary radioactive waste compared to the conventional process. The effect of various parameters, namely concentrations of HNO3, catalyst, oxalic acid and effect of the metal ion has been studied. Moreover, the robustness of the catalytic destruction method along with the kinetics of oxalate destruction reaction has been investigated. The process was also demonstrated with Pu supernatant generated from CORAL at 1 L scale.
草酸钚上清液需要一个处理步骤来进一步回收残余钚。由于溶液中存在的草酸根离子会给钚的回收带来问题，因此需要对其进行破坏。在本研究中，详细研究了基于 Mn2+ 催化销毁草酸根离子的方法，因为与传统工艺相比，这种方法可以最大限度地减少二次放射性废物的产生。研究了各种参数的影响，即 HNO3、催化剂、草酸的浓度以及金属离子的影响。此外，还研究了催化销毁方法的稳健性以及草酸销毁反应的动力学。还用 1 升规模的 CORAL 产生的 Pu 上清液演示了这一过程。
{"title":"Catalytic destruction of oxalate in the supernatant stream generated during plutonium reconversion process","authors":"Arvind Prasad, Kadukkappilly S. Vijayan, Ravinuthala V. S. Rao, Desigan Narasimhan, Ananthasivan Krishnamoorty","doi":"10.1515/ract-2023-0211","DOIUrl":"https://doi.org/10.1515/ract-2023-0211","url":null,"abstract":"Plutonium oxalate supernatant requires a treatment step for further recovery of the residual Pu. As the oxalate ion present in the solution poses problems during the recovery of Pu, it needs to be destroyed. In the present work, Mn<jats:sup>2+</jats:sup> based catalytic destruction of oxalate ion was studied in detail, as it could minimize the generation of secondary radioactive waste compared to the conventional process. The effect of various parameters, namely concentrations of HNO<jats:sub>3</jats:sub>, catalyst, oxalic acid and effect of the metal ion has been studied. Moreover, the robustness of the catalytic destruction method along with the kinetics of oxalate destruction reaction has been investigated. The process was also demonstrated with Pu supernatant generated from CORAL at 1 L scale.","PeriodicalId":21167,"journal":{"name":"Radiochimica Acta","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139759129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The present paper describes a simple method for the determination of uranium in uranium process stream solutions by reversed-phase liquid chromatographic method using C18 column, mixture of α-hydroxy isobutyric acid and methanol as eluent and flow-through spectrophotometer detector. This method has an advantage that interfering elements like rare-earth elements do not retain on the column and elute near the solvent peak thereby not interfering with uranium elution peak. Different eluents and parameters like pH, concentration of eluent are studied for the purpose. The spiking standard recovery was found to be more than 90 %. The developed method has been compared with other techniques and found to be in agreement.
{"title":"Reverse phase liquid chromatographic method for the measurement of uranium in process stream solutions from uranium extraction facility","authors":"Yarasi Balaji Rao, Shehanaz Bano, Putta V. Nagendra Kumar, Dinesh Srivastava","doi":"10.1515/ract-2023-0187","DOIUrl":"https://doi.org/10.1515/ract-2023-0187","url":null,"abstract":"The present paper describes a simple method for the determination of uranium in uranium process stream solutions by reversed-phase liquid chromatographic method using C18 column, mixture of α-hydroxy isobutyric acid and methanol as eluent and flow-through spectrophotometer detector. This method has an advantage that interfering elements like rare-earth elements do not retain on the column and elute near the solvent peak thereby not interfering with uranium elution peak. Different eluents and parameters like pH, concentration of eluent are studied for the purpose. The spiking standard recovery was found to be more than 90 %. The developed method has been compared with other techniques and found to be in agreement.","PeriodicalId":21167,"journal":{"name":"Radiochimica Acta","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139759248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yarasi Balaji Rao, Sirivella N. V. M. S. Gupta, Putta V. Nagendra Kumar, Dinesh Srivastava
The present paper discusses about the method developed for complete chemical characterization of Zirconium Washed and Dried Frit (WDF) and Reactor Grade ZrO2 powder which includes nonmetallic element sulphur using Inductively Coupled Plasma Optical Emission Spectrometer (ICP-OES). Studies have been carried-out on several important aspects of method development such as effect of matrix on determination of analytes, removal of matrix using different solvents, selection of interference free & sensitive wavelengths, calibration strategies like internal standard & standard addition, optimization of several instrumental parameters which includes RF power, plasma gas flow, nebulizer gas flow, nitrogen purging etc., and are discussed. A % RSD of less than 1 % for Zr and up to 3 % for other elements has been achieved in this method. The developed method has been validated using standard recovery of spiked real time samples with known amount of reference materials. Integrated approach adopted in the development of this method has resulted in reduction of analytical waste generated and also enabled to give quick analytical feedback to production plant for downstream processing.
{"title":"Zirconium sponge production: an integrated approach for chemical characterization of process intermediates using ICP-OES","authors":"Yarasi Balaji Rao, Sirivella N. V. M. S. Gupta, Putta V. Nagendra Kumar, Dinesh Srivastava","doi":"10.1515/ract-2023-0231","DOIUrl":"https://doi.org/10.1515/ract-2023-0231","url":null,"abstract":"The present paper discusses about the method developed for complete chemical characterization of Zirconium Washed and Dried Frit (WDF) and Reactor Grade ZrO<jats:sub>2</jats:sub> powder which includes nonmetallic element sulphur using Inductively Coupled Plasma Optical Emission Spectrometer (ICP-OES). Studies have been carried-out on several important aspects of method development such as effect of matrix on determination of analytes, removal of matrix using different solvents, selection of interference free & sensitive wavelengths, calibration strategies like internal standard & standard addition, optimization of several instrumental parameters which includes RF power, plasma gas flow, nebulizer gas flow, nitrogen purging etc., and are discussed. A % RSD of less than 1 % for Zr and up to 3 % for other elements has been achieved in this method. The developed method has been validated using standard recovery of spiked real time samples with known amount of reference materials. Integrated approach adopted in the development of this method has resulted in reduction of analytical waste generated and also enabled to give quick analytical feedback to production plant for downstream processing.","PeriodicalId":21167,"journal":{"name":"Radiochimica Acta","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139759125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Metal fuels are considered as the promising candidates for future fast breeder reactors. Pyro-chemical reprocessing is the ideal method for reprocessing spent metallic fuels due to the inherent process advantages. Electrorefining run was demonstrated in a hot cell facility with irradiated U-6 wt% Zr alloy at 500 °C using LiCl–KCl eutectic melt. In order to understand the behavior of the actinides and various fission products during high-temperature electrolysis, various process streams, viz., irradiated metal alloy fuel, the eutectic salt, and the cathode deposit were analyzed for the uranium, plutonium, and other fission product contents. Various methods employed for characterizing the process streams and the behaviors of some of the fission products during the electrolysis process are highlighted. The major gamma emitting radionuclides present in the irradiated fuel were 106Ru, 125Sb, 134Cs, 137Cs, 144Ce, and 154Eu. During electrorefining, cesium, cerium and europium were oxidized and dissolved in the molten media, whereas ruthenium and antimony remained in the anode basket. A minor contamination of zirconium was found in the cathode deposit.
{"title":"Radiochemical and chemical characterization of fuel, salt, and deposit from the electrorefining of irradiated U-6 wt% Zr in hot cells","authors":"Dwarapudi Bola Sankar, Rajeswari Seshadri, Kalaiyarasu Thirunavukkarasu, Gurudas Pakhui, Jakkula Siva Brahmaji Rao, Suranjan Bera, Balija Sreenivasulu, Kumaresan Radhakrishnan, Periasamy Manoravi, Venkataraman Jayaraman","doi":"10.1515/ract-2023-0203","DOIUrl":"https://doi.org/10.1515/ract-2023-0203","url":null,"abstract":"Metal fuels are considered as the promising candidates for future fast breeder reactors. Pyro-chemical reprocessing is the ideal method for reprocessing spent metallic fuels due to the inherent process advantages. Electrorefining run was demonstrated in a hot cell facility with irradiated U-6 wt% Zr alloy at 500 °C using LiCl–KCl eutectic melt. In order to understand the behavior of the actinides and various fission products during high-temperature electrolysis, various process streams, viz., irradiated metal alloy fuel, the eutectic salt, and the cathode deposit were analyzed for the uranium, plutonium, and other fission product contents. Various methods employed for characterizing the process streams and the behaviors of some of the fission products during the electrolysis process are highlighted. The major gamma emitting radionuclides present in the irradiated fuel were <jats:sup>106</jats:sup>Ru, <jats:sup>125</jats:sup>Sb, <jats:sup>134</jats:sup>Cs, <jats:sup>137</jats:sup>Cs, <jats:sup>144</jats:sup>Ce, and <jats:sup>154</jats:sup>Eu. During electrorefining, cesium, cerium and europium were oxidized and dissolved in the molten media, whereas ruthenium and antimony remained in the anode basket. A minor contamination of zirconium was found in the cathode deposit.","PeriodicalId":21167,"journal":{"name":"Radiochimica Acta","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139772984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Synthesis of PSMA-617, a peptide based ligand used in the preparation of nuclear medicine, 177Lu-PSMA-617, for the treatment of prostate cancer, is demonstrated in 6 steps, starting from appropriately protected amino acid building blocks. A solution phase Boc-strategy was adopted for the synthesis of peptide, wherein deprotection of carbamate group using HCl (g), was employed as the key step. The synthesis furnished PSMA-617 in purity >99.5 % as confirmed by HPLC analysis. ESI-MS and NMR analysis supported the structural integrity of the compound. The synthesized ligand was radiolabelled using 177Lu to generate the desired radiopharmaceutical, 177Lu-PSMA-617, in radiochemical purity >98 %, as revealed by radio HPLC and TLC analysis. This establishes its potential as a nuclear medicine for therapeutic application.
{"title":"Total chemical synthesis of PSMA-617: an API for prostate cancer endotherapeutic applications","authors":"Kalangattu Sundaran Ajish Kumar, Anupam Mathur","doi":"10.1515/ract-2023-0205","DOIUrl":"https://doi.org/10.1515/ract-2023-0205","url":null,"abstract":"Synthesis of PSMA-617, a peptide based ligand used in the preparation of nuclear medicine, <jats:sup>177</jats:sup>Lu-PSMA-617, for the treatment of prostate cancer, is demonstrated in 6 steps, starting from appropriately protected amino acid building blocks. A solution phase Boc-strategy was adopted for the synthesis of peptide, wherein deprotection of carbamate group using HCl (g), was employed as the key step. The synthesis furnished PSMA-617 in purity >99.5 % as confirmed by HPLC analysis. ESI-MS and NMR analysis supported the structural integrity of the compound. The synthesized ligand was radiolabelled using <jats:sup>177</jats:sup>Lu to generate the desired radiopharmaceutical, <jats:sup>177</jats:sup>Lu-PSMA-617, in radiochemical purity >98 %, as revealed by radio HPLC and TLC analysis. This establishes its potential as a nuclear medicine for therapeutic application.","PeriodicalId":21167,"journal":{"name":"Radiochimica Acta","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139759123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
97Ru is a key radionuclide sought for diagnostic imaging due to its low-energy and intense γ-rays of 215.7 keV and 324.5 keV. New reaction routes to produce this radionuclide are constantly being investigated. A crucial step in carrying out such reactions is a reliable beforehand estimate of the production cross section of radionuclide and optimization conditions through robust theoretical frameworks. Existing literature on α + 95Mo reaction has been freshly examined to understand the excitation function of 97Ru. The data have been compared to other reactions of different projectiles on medium-mass targets. The reaction codes pace4, empire-3.2.2, and talys-1.96 have been employed to decipher the reaction mechanism and check the predictive ability of underlying theoretical models. The yield of 97Ru at different projectile energies and thick target yield in the optimum energy range has also been determined from the theoretical modeling.
{"title":"Theoretical analysis of light and heavy-ion induced reactions: production of medically relevant 97Ru","authors":"Malvika Sagwal, Moumita Maiti","doi":"10.1515/ract-2023-0199","DOIUrl":"https://doi.org/10.1515/ract-2023-0199","url":null,"abstract":"<jats:sup>97</jats:sup>Ru is a key radionuclide sought for diagnostic imaging due to its low-energy and intense γ-rays of 215.7 keV and 324.5 keV. New reaction routes to produce this radionuclide are constantly being investigated. A crucial step in carrying out such reactions is a reliable beforehand estimate of the production cross section of radionuclide and optimization conditions through robust theoretical frameworks. Existing literature on <jats:italic>α</jats:italic> + <jats:sup>95</jats:sup>Mo reaction has been freshly examined to understand the excitation function of <jats:sup>97</jats:sup>Ru. The data have been compared to other reactions of different projectiles on medium-mass targets. The reaction codes <jats:sc>pace</jats:sc>4, <jats:sc>empire</jats:sc>-3.2.2, and <jats:sc>talys</jats:sc>-1.96 have been employed to decipher the reaction mechanism and check the predictive ability of underlying theoretical models. The yield of <jats:sup>97</jats:sup>Ru at different projectile energies and thick target yield in the optimum energy range has also been determined from the theoretical modeling.","PeriodicalId":21167,"journal":{"name":"Radiochimica Acta","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139759121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mahesh Choudhary, Namrata Singh, Aman Sharma, Aman Gandhi, Mahima Upadhyay, Rebecca Pachuau, Sandipan Dasgupta, Jagannath Datta, Ajay Kumar
Excitation functions of alpha-particle induced nuclear reactions on natSn have been presented in the 11–40 MeV energy range. In the present study, the stacked-foil activation technique followed by offline gamma-ray spectrometry was used to measure the production of 119Te, 121Te, 122Sb and 126Sb from alpha-particle induced reactions on natSn. The TALYS nuclear code was used to calculate the theoretical predictions of the excitation functions of natSn(α,x) nuclear reactions. The measured data of the above-mentioned nuclear reactions were compared with the theoretical predictions and the experimental results available from EXFOR. In this study, covariance analysis was performed to calculate the uncertainty propagation in the measured cross sections.
{"title":"Excitation functions of alpha-particle induced nuclear reactions on nat Sn","authors":"Mahesh Choudhary, Namrata Singh, Aman Sharma, Aman Gandhi, Mahima Upadhyay, Rebecca Pachuau, Sandipan Dasgupta, Jagannath Datta, Ajay Kumar","doi":"10.1515/ract-2023-0202","DOIUrl":"https://doi.org/10.1515/ract-2023-0202","url":null,"abstract":"Excitation functions of alpha-particle induced nuclear reactions on <jats:sup> <jats:italic>nat</jats:italic> </jats:sup>Sn have been presented in the 11–40 MeV energy range. In the present study, the stacked-foil activation technique followed by offline gamma-ray spectrometry was used to measure the production of <jats:sup>119</jats:sup>Te, <jats:sup>121</jats:sup>Te, <jats:sup>122</jats:sup>Sb and <jats:sup>126</jats:sup>Sb from alpha-particle induced reactions on <jats:sup> <jats:italic>nat</jats:italic> </jats:sup>Sn. The TALYS nuclear code was used to calculate the theoretical predictions of the excitation functions of <jats:sup> <jats:italic>nat</jats:italic> </jats:sup>Sn(<jats:italic>α</jats:italic>,x) nuclear reactions. The measured data of the above-mentioned nuclear reactions were compared with the theoretical predictions and the experimental results available from EXFOR. In this study, covariance analysis was performed to calculate the uncertainty propagation in the measured cross sections.","PeriodicalId":21167,"journal":{"name":"Radiochimica Acta","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139759126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sourav Patra, Sachin Jadhav, Priyalata Shetty, Khajan Singh, Ardhi Rajeswari, K. V. Vimalnath, Avik Chakraborty, Rubel Chakravarty, Sudipta Chakraborty
Glomerular filtration rate (GFR) could be determined more accurately using renal positron emission tomography (PET) than conventional gamma imaging. Copper-64 [T½ = 12.7 h, Eβ+ (max) = 653 keV, β+ branching ratio = 17.8 %, 1346 keV γ-photon (0.54 %), EC (43.8 %), β− emission (38.4 %)] in the form of its hydrophilic complex with 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) is proposed as a potent formulation for renal PET imaging. A lyophilized kit was developed for formulation of ∼370 MBq dose of [64Cu]Cu–NOTA complex in a facile single step process using 64Cu produced by thermal neutron activation in a research reactor. The complex could be synthesized with >99 % yield and retained its integrity even when challenged by apoferritin. The rapid accumulation of [64Cu]Cu–NOTA in the kidney and clearance through urinary path was demonstrated using PET/CT imaging and ex vivo biodistribution study carried out in healthy Wistar rats to elucidate its effectiveness as a renal PET-imaging agent.
{"title":"Preparation of [64Cu]Cu–NOTA complex as a potential renal PET imaging agent using 64Cu produced via the direct activation route","authors":"Sourav Patra, Sachin Jadhav, Priyalata Shetty, Khajan Singh, Ardhi Rajeswari, K. V. Vimalnath, Avik Chakraborty, Rubel Chakravarty, Sudipta Chakraborty","doi":"10.1515/ract-2023-0206","DOIUrl":"https://doi.org/10.1515/ract-2023-0206","url":null,"abstract":"Glomerular filtration rate (GFR) could be determined more accurately using renal positron emission tomography (PET) than conventional gamma imaging. Copper-64 [<jats:italic>T</jats:italic> <jats:sub>½</jats:sub> = 12.7 h, <jats:italic>E</jats:italic> <jats:sub>β+</jats:sub> (max) = 653 keV, β<jats:sup>+</jats:sup> branching ratio = 17.8 %, 1346 keV γ-photon (0.54 %), EC (43.8 %), β<jats:sup>−</jats:sup> emission (38.4 %)] in the form of its hydrophilic complex with 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) is proposed as a potent formulation for renal PET imaging. A lyophilized kit was developed for formulation of ∼370 MBq dose of [<jats:sup>64</jats:sup>Cu]Cu–NOTA complex in a facile single step process using <jats:sup>64</jats:sup>Cu produced by thermal neutron activation in a research reactor. The complex could be synthesized with >99 % yield and retained its integrity even when challenged by apoferritin. The rapid accumulation of [<jats:sup>64</jats:sup>Cu]Cu–NOTA in the kidney and clearance through urinary path was demonstrated using PET/CT imaging and <jats:italic>ex vivo</jats:italic> biodistribution study carried out in healthy Wistar rats to elucidate its effectiveness as a renal PET-imaging agent.","PeriodicalId":21167,"journal":{"name":"Radiochimica Acta","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139759219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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