首页 > 最新文献

Reviews in Medical Virology最新文献

英文 中文
Breakthrough infection and reinfection in patients with mpox. 麻风病人的突破性感染和再感染。
IF 9 2区 医学 Q1 VIROLOGY Pub Date : 2024-03-01 DOI: 10.1002/rmv.2522
Wenyi Jiang, Yibo Hu, Xiu Yang, Lingli Hou, Jingjing Zhang, Hong Niu, Congxia Hu, Jihui Lin

Recently, patients with Mpox breakthrough infection or reinfection were constantly reported. However, the induction, risk factors, and important clinical symptoms of breakthrough infection and reinfection of Mpox virus (MPXV), as well as the factors affecting the effectiveness of Mpox vaccine are not characterized. Herein, a literature review was preformed to summarize the risk factors and important clinical symptoms of patients with Mpox breakthrough infection or reinfection, as well as the factors affecting the effectiveness of smallpox vaccine against Mpox. Results showed that MSM sexual behavior, condomless sexual behavior, multiple sexual partners, close contact, HIV infection, and the presence of comorbidity are important risk factors for Mpox breakthrough infection and reinfection. Genital ulcers, proctitis, and lymphadenopathy are the important clinical symptoms of Mpox breakthrough infection and reinfection. The effectiveness of emergent vaccination of smallpox vaccine for post-exposure of MPXV is associated with smallpox vaccination history, interval between exposure and vaccination, and history of HIV infection. This review provides a better understanding for the risk factors and important clinical symptoms of Mpox breakthrough infection and reinfection, as well as the formulation of Mpox vaccine vaccination strategies.

最近,不断有关于痘病毒突破性感染或再感染患者的报道。然而,痘苗病毒(MPXV)突破性感染和再感染的诱发因素、危险因素和重要临床症状,以及影响痘苗疫苗有效性的因素均不明确。本文通过文献综述总结了天花病毒突破性感染或再感染患者的危险因素和重要临床症状,以及影响天花疫苗预防天花病毒效果的因素。结果显示,MSM性行为、无安全套性行为、多个性伴侣、密切接触、HIV感染和合并症是天花突破性感染和再感染的重要危险因素。生殖器溃疡、直肠炎和淋巴结病是 Mpox 突破性感染和再感染的重要临床症状。天花疫苗紧急接种对暴露后 MPXV 的有效性与天花疫苗接种史、暴露与接种之间的间隔时间以及艾滋病病毒感染史有关。本综述有助于更好地了解天花疫苗突破性感染和再感染的风险因素和重要临床症状,以及天花疫苗接种策略的制定。
{"title":"Breakthrough infection and reinfection in patients with mpox.","authors":"Wenyi Jiang, Yibo Hu, Xiu Yang, Lingli Hou, Jingjing Zhang, Hong Niu, Congxia Hu, Jihui Lin","doi":"10.1002/rmv.2522","DOIUrl":"10.1002/rmv.2522","url":null,"abstract":"<p><p>Recently, patients with Mpox breakthrough infection or reinfection were constantly reported. However, the induction, risk factors, and important clinical symptoms of breakthrough infection and reinfection of Mpox virus (MPXV), as well as the factors affecting the effectiveness of Mpox vaccine are not characterized. Herein, a literature review was preformed to summarize the risk factors and important clinical symptoms of patients with Mpox breakthrough infection or reinfection, as well as the factors affecting the effectiveness of smallpox vaccine against Mpox. Results showed that MSM sexual behavior, condomless sexual behavior, multiple sexual partners, close contact, HIV infection, and the presence of comorbidity are important risk factors for Mpox breakthrough infection and reinfection. Genital ulcers, proctitis, and lymphadenopathy are the important clinical symptoms of Mpox breakthrough infection and reinfection. The effectiveness of emergent vaccination of smallpox vaccine for post-exposure of MPXV is associated with smallpox vaccination history, interval between exposure and vaccination, and history of HIV infection. This review provides a better understanding for the risk factors and important clinical symptoms of Mpox breakthrough infection and reinfection, as well as the formulation of Mpox vaccine vaccination strategies.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"34 2","pages":"e2522"},"PeriodicalIF":9.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139723873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coinfections in human papillomavirus associated cancers and prophylactic recommendations. 人类乳头瘤病毒相关癌症的合并感染和预防建议。
IF 9 2区 医学 Q1 VIROLOGY Pub Date : 2024-03-01 DOI: 10.1002/rmv.2524
Gayathri Ashok, Soumya Basu, Priyamvada Priyamvada, Anand Anbarasu, Sreenivasulu Chintala, Sudha Ramaiah

The Human Papillomavirus (HPV) infection is responsible for more than 80% of reported cervical cancer and other virus-associated tumours. Although this global threat can be controlled using effective vaccination strategies, a growing perturbation of HPV infection is an emerging coinfection likely to increase the severity of the infection in humans. Moreover, these coinfections prolong the HPV infections, thereby risking the chances for oncogenic progression. The present review consolidated the clinically significant microbial coinfections/co-presence associated with HPV and their underlying molecular mechanisms. We discussed the gaps and concerns associated with demography, present vaccination strategies, and other prophylactic limitations. We concluded our review by highlighting the potential clinical as well as emerging computational intervention measures to kerb down HPV-associated severities.

据报道,80%以上的宫颈癌和其他病毒相关肿瘤是由人类乳头瘤病毒(HPV)感染引起的。虽然可以通过有效的疫苗接种策略来控制这一全球性威胁,但人类乳头瘤病毒感染的一个日益严重的干扰因素是新出现的合并感染,这种合并感染可能会增加人类感染的严重程度。此外,这些合并感染会延长人乳头瘤病毒感染的时间,从而增加致癌进展的风险。本综述整合了与人乳头瘤病毒相关的具有临床意义的微生物合并感染/共存及其潜在的分子机制。我们讨论了与人口统计学、目前的疫苗接种策略以及其他预防性限制相关的差距和问题。最后,我们强调了潜在的临床和新兴的计算干预措施,以降低人乳头瘤病毒相关的严重程度。
{"title":"Coinfections in human papillomavirus associated cancers and prophylactic recommendations.","authors":"Gayathri Ashok, Soumya Basu, Priyamvada Priyamvada, Anand Anbarasu, Sreenivasulu Chintala, Sudha Ramaiah","doi":"10.1002/rmv.2524","DOIUrl":"10.1002/rmv.2524","url":null,"abstract":"<p><p>The Human Papillomavirus (HPV) infection is responsible for more than 80% of reported cervical cancer and other virus-associated tumours. Although this global threat can be controlled using effective vaccination strategies, a growing perturbation of HPV infection is an emerging coinfection likely to increase the severity of the infection in humans. Moreover, these coinfections prolong the HPV infections, thereby risking the chances for oncogenic progression. The present review consolidated the clinically significant microbial coinfections/co-presence associated with HPV and their underlying molecular mechanisms. We discussed the gaps and concerns associated with demography, present vaccination strategies, and other prophylactic limitations. We concluded our review by highlighting the potential clinical as well as emerging computational intervention measures to kerb down HPV-associated severities.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"34 2","pages":"e2524"},"PeriodicalIF":9.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139906406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and laboratory diagnosis of Mayaro virus (MAYV): Current status and opportunities for further development. 玛雅罗病毒(MAYV)的临床和实验室诊断:现状和进一步发展的机遇。
IF 9 2区 医学 Q1 VIROLOGY Pub Date : 2024-03-01 DOI: 10.1002/rmv.2528
Severino Jefferson Ribeiro da Silva, Larissa Krokovsky

The recent outbreaks related to Mayaro virus (MAYV) infection in the Americas have brought this neglected virus as a potential threat to global public health. Given the range of symptoms that can be associated with MAYV infection, it can be challenging to diagnose individuals based on clinical signs, especially in countries with simultaneous circulation of other mosquito-borne viruses, such as dengue virus (DENV) and chikungunya virus (CHIKV). With this challenge in mind, laboratory-based diagnosis assumes a critical role in the introduction of measures to help prevent virus dissemination and to adequately treat patients. In this review, we provide an overview of the clinical features reported in infected patients and currently available laboratory tools that are used for MAYV diagnosis, discussing their advances, advantages, and limitations to apply in the field. Moreover, we explore novel point-of-care (PoC) diagnostic platforms that can provide de-centralised diagnostics for use in areas with limited laboratory infrastructure.

最近在美洲爆发的与马雅罗病毒(MAYV)感染有关的疫情使这种被忽视的病毒成为全球公共卫生的潜在威胁。鉴于马雅罗病毒感染可能伴有多种症状,根据临床症状对患者进行诊断具有挑战性,尤其是在登革热病毒(DENV)和基孔肯雅病毒(CHIKV)等其他蚊媒病毒同时流行的国家。考虑到这一挑战,实验室诊断在采取措施帮助预防病毒传播和充分治疗患者方面发挥着至关重要的作用。在这篇综述中,我们概述了感染患者的临床特征和目前用于 MAYV 诊断的实验室工具,讨论了这些工具在该领域应用的进展、优势和局限性。此外,我们还探讨了新型护理点 (PoC) 诊断平台,该平台可提供非集中式诊断,供实验室基础设施有限的地区使用。
{"title":"Clinical and laboratory diagnosis of Mayaro virus (MAYV): Current status and opportunities for further development.","authors":"Severino Jefferson Ribeiro da Silva, Larissa Krokovsky","doi":"10.1002/rmv.2528","DOIUrl":"10.1002/rmv.2528","url":null,"abstract":"<p><p>The recent outbreaks related to Mayaro virus (MAYV) infection in the Americas have brought this neglected virus as a potential threat to global public health. Given the range of symptoms that can be associated with MAYV infection, it can be challenging to diagnose individuals based on clinical signs, especially in countries with simultaneous circulation of other mosquito-borne viruses, such as dengue virus (DENV) and chikungunya virus (CHIKV). With this challenge in mind, laboratory-based diagnosis assumes a critical role in the introduction of measures to help prevent virus dissemination and to adequately treat patients. In this review, we provide an overview of the clinical features reported in infected patients and currently available laboratory tools that are used for MAYV diagnosis, discussing their advances, advantages, and limitations to apply in the field. Moreover, we explore novel point-of-care (PoC) diagnostic platforms that can provide de-centralised diagnostics for use in areas with limited laboratory infrastructure.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"34 2","pages":"e2528"},"PeriodicalIF":9.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hijacking and rewiring of host CircRNA/miRNA/mRNA competitive endogenous RNA (ceRNA) regulatory networks by oncoviruses during development of viral cancers. 在病毒性癌症的发展过程中,肿瘤病毒劫持并重新连接宿主CircRNA/miRNA/mRNA竞争性内源性RNA(ceRNA)调控网络。
IF 9 2区 医学 Q1 VIROLOGY Pub Date : 2024-03-01 DOI: 10.1002/rmv.2530
Mohammad Javad Kamali, Mohammad Salehi, Mehrnaz Mostafavi, Reza Morovatshoar, Mitra Akbari, Narges Latifi, Omid Barzegari, Fatemeh Ghadimi, Abdolreza Daraei

A significant portion of human cancers are caused by oncoviruses (12%-25%). Oncoviruses employ various strategies to promote their replication and induce tumourigenesis in host cells, one of which involves modifying the gene expression patterns of the host cells, leading to the rewiring of genes and resulting in significant changes in cellular processes and signalling pathways. In recent studies, a specific mode of gene regulation known as circular RNA (circRNA)-mediated competing endogenous RNA (ceRNA) networks has emerged as a key player in this context. CircRNAs, a class of non-coding RNA molecules, can interact with other RNA molecules, such as mRNAs and microRNAs (miRNAs), through a process known as ceRNA crosstalk. This interaction occurs when circRNAs, acting as sponges, sequester miRNAs, thereby preventing them from binding to their target mRNAs and modulating their expression. By rewiring the host cell genome, oncoviruses have the ability to manipulate the expression and activity of circRNAs, thereby influencing the ceRNA networks that can profoundly impact cellular processes such as cell proliferation, differentiation, apoptosis, and immune responses. This review focuses on a comprehensive evaluation of the latest findings on the involvement of virus-induced reprogramming of host circRNA-mediated ceRNA networks in the development and pathophysiology of human viral cancers, including cervical cancer, gastric cancer, nasopharyngeal carcinoma, Kaposi's sarcoma, hepatocellular carcinoma, and diffuse large B cell lymphoma. Understanding these mechanisms can improve our knowledge of how oncoviruses contribute to human tumourigenesis and identify potential targets for developing optimised therapies and diagnostic tools for viral cancers.

相当一部分人类癌症是由肿瘤病毒(12%-25%)引起的。肿瘤病毒采用各种策略促进宿主细胞的复制并诱导肿瘤发生,其中之一是改变宿主细胞的基因表达模式,从而导致基因重联,使细胞过程和信号通路发生重大变化。在最近的研究中,一种称为环状 RNA(circRNA)介导的竞争性内源性 RNA(ceRNA)网络的特定基因调控模式已成为这方面的一个关键角色。环状 RNA 是一类非编码 RNA 分子,可通过一种称为 ceRNA 串扰的过程与其他 RNA 分子(如 mRNA 和 microRNA(miRNA))相互作用。当 circRNA 作为海绵将 miRNA 封存起来,从而阻止它们与目标 mRNA 结合并调节其表达时,这种相互作用就会发生。通过重新连接宿主细胞基因组,肿瘤病毒有能力操纵 circRNA 的表达和活性,从而影响 ceRNA 网络,对细胞增殖、分化、凋亡和免疫反应等细胞过程产生深远影响。本综述着重全面评估病毒诱导的宿主 circRNA 介导的 ceRNA 网络重编程参与人类病毒性癌症(包括宫颈癌、胃癌、鼻咽癌、卡波西肉瘤、肝细胞癌和弥漫性大 B 细胞淋巴瘤)的发展和病理生理学的最新发现。了解这些机制可以提高我们对肿瘤病毒如何导致人类肿瘤发生的认识,并确定开发病毒性癌症优化疗法和诊断工具的潜在目标。
{"title":"Hijacking and rewiring of host CircRNA/miRNA/mRNA competitive endogenous RNA (ceRNA) regulatory networks by oncoviruses during development of viral cancers.","authors":"Mohammad Javad Kamali, Mohammad Salehi, Mehrnaz Mostafavi, Reza Morovatshoar, Mitra Akbari, Narges Latifi, Omid Barzegari, Fatemeh Ghadimi, Abdolreza Daraei","doi":"10.1002/rmv.2530","DOIUrl":"10.1002/rmv.2530","url":null,"abstract":"<p><p>A significant portion of human cancers are caused by oncoviruses (12%-25%). Oncoviruses employ various strategies to promote their replication and induce tumourigenesis in host cells, one of which involves modifying the gene expression patterns of the host cells, leading to the rewiring of genes and resulting in significant changes in cellular processes and signalling pathways. In recent studies, a specific mode of gene regulation known as circular RNA (circRNA)-mediated competing endogenous RNA (ceRNA) networks has emerged as a key player in this context. CircRNAs, a class of non-coding RNA molecules, can interact with other RNA molecules, such as mRNAs and microRNAs (miRNAs), through a process known as ceRNA crosstalk. This interaction occurs when circRNAs, acting as sponges, sequester miRNAs, thereby preventing them from binding to their target mRNAs and modulating their expression. By rewiring the host cell genome, oncoviruses have the ability to manipulate the expression and activity of circRNAs, thereby influencing the ceRNA networks that can profoundly impact cellular processes such as cell proliferation, differentiation, apoptosis, and immune responses. This review focuses on a comprehensive evaluation of the latest findings on the involvement of virus-induced reprogramming of host circRNA-mediated ceRNA networks in the development and pathophysiology of human viral cancers, including cervical cancer, gastric cancer, nasopharyngeal carcinoma, Kaposi's sarcoma, hepatocellular carcinoma, and diffuse large B cell lymphoma. Understanding these mechanisms can improve our knowledge of how oncoviruses contribute to human tumourigenesis and identify potential targets for developing optimised therapies and diagnostic tools for viral cancers.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"34 2","pages":"e2530"},"PeriodicalIF":9.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140185442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomarkers of transfusion transmitted occult hepatitis B virus infection: Where are we and what next? 输血传播隐性乙型肝炎病毒感染的生物标志物:进展如何?
IF 9 2区 医学 Q1 VIROLOGY Pub Date : 2024-03-01 DOI: 10.1002/rmv.2525
Michael X Fu, Peter Simmonds, Monique Andersson, Heli Harvala

Blood transfusion is a vital procedure, where transfusion-transmitted infection of hepatitis B virus (HBV) remains an important issue, especially from blood donors with occult hepatitis B virus infection (OBI). Occult hepatitis B virus infection is a complex entity to detect using surrogate blood biomarkers for intrahepatic viral transcriptional activity, requiring a continually refined battery of tests utilised for screening. This review aims to critically evaluate the latest advances in the current blood biomarkers to guide the identification of OBI donors and discuss novel HBV markers that could be introduced in future diagnostic practice. Challenges in detecting low HBV surface antigen levels, mutants, and complexes necessitate ultrasensitive multivalent dissociation assays, whilst HBV DNA testing requires improved sensitivity but worsens inaccessibility. Anti-core antibody assays defer almost all potentially infectious donations but have low specificity, and titres of anti-surface antibodies that prevent infectivity are poorly defined with suboptimal sensitivity. The challenges associated with these traditional blood HBV markers create an urgent need for alternative biomarkers that would help us better understand the OBI. Emerging viral biomarkers, such as pre-genomic RNA and HBV core-related antigen, immunological HBV biomarkers of T-cell reactivity and cytokine levels, and host biomarkers of microRNA and human leucocyte antigen molecules, present potential advances to gauge intrahepatic activity more accurately. Further studies on these markers may uncover an optimal diagnostic algorithm for OBI using quantification of various novel and traditional blood HBV markers. Addressing critical knowledge gaps identified in this review would decrease the residual risk of transfusion-transmitted HBV infection without compromising the sustainability of blood supplies.

输血是一项重要的程序,其中乙型肝炎病毒(HBV)的输血传播感染仍是一个重要问题,尤其是来自隐性乙型肝炎病毒感染(OBI)献血者的感染。隐匿性乙型肝炎病毒感染是一个复杂的实体,需要使用肝内病毒转录活性的代用血液生物标志物进行检测,因此需要不断完善用于筛查的一系列检测方法。本综述旨在批判性地评估当前血液生物标志物的最新进展,以指导确定 OBI 献血者,并讨论可在未来诊断实践中引入的新型 HBV 标志物。由于在检测低水平 HBV 表面抗原、突变体和复合物方面存在挑战,因此有必要采用超灵敏的多价解离测定法,而 HBV DNA 检测需要提高灵敏度,但却增加了不可及性。抗核心抗体检测几乎可以推迟所有潜在感染性捐献,但特异性较低,而防止感染的抗表面抗体滴度定义不清,灵敏度也不理想。这些传统的血液 HBV 标志物所面临的挑战使我们急需能帮助我们更好地了解 OBI 的替代生物标志物。新出现的病毒生物标记物,如前基因组 RNA 和 HBV 核心相关抗原、T 细胞反应性和细胞因子水平等免疫学 HBV 生物标记物,以及微 RNA 和人类白细胞抗原分子等宿主生物标记物,为更准确地评估肝内活动提供了潜在的进展。对这些标志物的进一步研究可能会发现一种利用各种新型和传统血液 HBV 标志物定量的 OBI 最佳诊断算法。解决本综述中发现的关键知识缺口将降低输血传播 HBV 感染的残余风险,同时又不影响血液供应的可持续性。
{"title":"Biomarkers of transfusion transmitted occult hepatitis B virus infection: Where are we and what next?","authors":"Michael X Fu, Peter Simmonds, Monique Andersson, Heli Harvala","doi":"10.1002/rmv.2525","DOIUrl":"10.1002/rmv.2525","url":null,"abstract":"<p><p>Blood transfusion is a vital procedure, where transfusion-transmitted infection of hepatitis B virus (HBV) remains an important issue, especially from blood donors with occult hepatitis B virus infection (OBI). Occult hepatitis B virus infection is a complex entity to detect using surrogate blood biomarkers for intrahepatic viral transcriptional activity, requiring a continually refined battery of tests utilised for screening. This review aims to critically evaluate the latest advances in the current blood biomarkers to guide the identification of OBI donors and discuss novel HBV markers that could be introduced in future diagnostic practice. Challenges in detecting low HBV surface antigen levels, mutants, and complexes necessitate ultrasensitive multivalent dissociation assays, whilst HBV DNA testing requires improved sensitivity but worsens inaccessibility. Anti-core antibody assays defer almost all potentially infectious donations but have low specificity, and titres of anti-surface antibodies that prevent infectivity are poorly defined with suboptimal sensitivity. The challenges associated with these traditional blood HBV markers create an urgent need for alternative biomarkers that would help us better understand the OBI. Emerging viral biomarkers, such as pre-genomic RNA and HBV core-related antigen, immunological HBV biomarkers of T-cell reactivity and cytokine levels, and host biomarkers of microRNA and human leucocyte antigen molecules, present potential advances to gauge intrahepatic activity more accurately. Further studies on these markers may uncover an optimal diagnostic algorithm for OBI using quantification of various novel and traditional blood HBV markers. Addressing critical knowledge gaps identified in this review would decrease the residual risk of transfusion-transmitted HBV infection without compromising the sustainability of blood supplies.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"34 2","pages":"e2525"},"PeriodicalIF":9.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139906405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overview of reemerging mpox infection with a focus on neurological manifestations. 新发麻风腮病毒感染概述,重点关注神经系统表现。
IF 9 2区 医学 Q1 VIROLOGY Pub Date : 2024-03-01 DOI: 10.1002/rmv.2527
Mohammed Alissa, Abdullah Alghamdi, Suad A Alghamdi

Mpox, a reemerging zoonotic disease caused by the mpox virus, has garnered increasing attention due to its potential for severe clinical manifestations. While the cutaneous and systemic presentations of mpox have been well-documented, its neurological complications have recently emerged as an area of concern. This review provides a brief overview of the neurological aspects of mpox infection, highlighting the key findings and challenges in understanding and managing these complications. Neurological manifestations in mpox patients range from mild symptoms such as headaches and dizziness to more severe conditions, including encephalitis and seizures. The pathogenesis of neurological involvement is not yet fully elucidated but is thought to involve viral dissemination to the central nervous system. This dissemination may occur through haematogenous or neuronal routes, contributing to the diverse clinical spectrum observed. Early recognition and diagnosis of neurological complications in mpox are crucial for implementing appropriate therapeutic interventions and improving patient outcomes.

麻腮风是由麻腮风病毒引起的一种重新出现的人畜共患疾病,因其可能出现严重的临床表现而日益受到关注。尽管痘疹的皮肤和全身表现已得到充分证实,但其神经系统并发症近来也成为一个值得关注的领域。本综述简要概述了水痘感染的神经系统方面,重点介绍了在了解和处理这些并发症方面的主要发现和挑战。麻风病人的神经系统表现从头痛和头晕等轻微症状到脑炎和癫痫发作等更严重的病症不等。神经系统受累的发病机制尚未完全阐明,但据认为涉及病毒向中枢神经系统的传播。这种传播可能通过血液或神经元途径发生,从而导致临床表现多种多样。早期识别和诊断水痘的神经系统并发症对于实施适当的治疗干预和改善患者预后至关重要。
{"title":"Overview of reemerging mpox infection with a focus on neurological manifestations.","authors":"Mohammed Alissa, Abdullah Alghamdi, Suad A Alghamdi","doi":"10.1002/rmv.2527","DOIUrl":"10.1002/rmv.2527","url":null,"abstract":"<p><p>Mpox, a reemerging zoonotic disease caused by the mpox virus, has garnered increasing attention due to its potential for severe clinical manifestations. While the cutaneous and systemic presentations of mpox have been well-documented, its neurological complications have recently emerged as an area of concern. This review provides a brief overview of the neurological aspects of mpox infection, highlighting the key findings and challenges in understanding and managing these complications. Neurological manifestations in mpox patients range from mild symptoms such as headaches and dizziness to more severe conditions, including encephalitis and seizures. The pathogenesis of neurological involvement is not yet fully elucidated but is thought to involve viral dissemination to the central nervous system. This dissemination may occur through haematogenous or neuronal routes, contributing to the diverse clinical spectrum observed. Early recognition and diagnosis of neurological complications in mpox are crucial for implementing appropriate therapeutic interventions and improving patient outcomes.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"34 2","pages":"e2527"},"PeriodicalIF":9.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk of kidney and liver diseases after COVID-19 infection: A systematic review and meta-analysis. 感染 COVID-19 后患肝肾疾病的风险:系统回顾与荟萃分析。
IF 9 2区 医学 Q1 VIROLOGY Pub Date : 2024-03-01 DOI: 10.1002/rmv.2523
Bei Pan, Xiaoman Wang, Honghao Lai, Robin W M Vernooij, Xiyuan Deng, Ning Ma, Dan Li, Jiajie Huang, Weilong Zhao, Jinling Ning, Jianing Liu, Jinhui Tian, Long Ge, Kehu Yang

COVID-19 is not only associated with substantial acute liver and kidney injuries, but also with an elevated risk of post-acute sequelae involving the kidney and liver system. We aimed to investigate whether COVID-19 exposure increases the long-term risk of kidney and liver disease, and what are the magnitudes of these associations. We searched PubMed, Embase, Web of Science, ClinicalTrials.gov, and the Living Overview of the Evidence COVID-19 Repository for cohort studies estimating the association between COVID-19 and kidney and liver outcomes. Random-effects meta-analyses were performed to combine the results of the included studies. We assessed the certainty of the evidence using the Grading of Recommendations Assessment, Development and Evaluation approach. Fifteen cohort studies with more than 32 million participants were included in the systematic review COVID-19 was associated with a 35% greater risk of kidney diseases (10 more per 1000 persons; low certainty evidence) and 54% greater risk of liver disease (3 more per 1000 persons; low certainty evidence). The absolute increases due to COVID-19 for acute kidney injury, chronic kidney disease, and liver test abnormality were 3, 8, and 3 per 1000 persons, respectively. Subgroup analyses found no differences between different type of kidney and liver diseases. The findings provide further evidence for the association between COVID-19 and incident kidney and liver conditions. The absolute magnitude of the effect of COVID-19 on kidney and liver outcomes was, however, relatively small.

COVID-19 不仅与严重的急性肝肾损伤有关,还与肝肾系统急性后遗症的风险升高有关。我们旨在研究接触 COVID-19 是否会增加肝肾疾病的长期风险,以及这些关联的程度如何。我们检索了PubMed、Embase、Web of Science、ClinicalTrials.gov和Living Overview of the Evidence COVID-19 Repository,以了解估计COVID-19与肾脏和肝脏结果之间关系的队列研究。我们对纳入的研究结果进行了随机效应荟萃分析。我们采用 "建议分级评估、发展和评价 "方法对证据的确定性进行了评估。系统综述纳入了 15 项队列研究,参与者超过 3200 万人,COVID-19 与肾脏疾病风险增加 35% 相关(每 1000 人增加 10 人;低确定性证据),与肝脏疾病风险增加 54% 相关(每 1000 人增加 3 人;低确定性证据)。COVID-19导致急性肾损伤、慢性肾脏疾病和肝脏检测异常的绝对增加率分别为每千人3例、8例和3例。分组分析发现,不同类型的肾病和肝病之间没有差异。这些研究结果进一步证明了 COVID-19 与肾脏和肝脏疾病之间的关联。然而,COVID-19对肾脏和肝脏结果影响的绝对值相对较小。
{"title":"Risk of kidney and liver diseases after COVID-19 infection: A systematic review and meta-analysis.","authors":"Bei Pan, Xiaoman Wang, Honghao Lai, Robin W M Vernooij, Xiyuan Deng, Ning Ma, Dan Li, Jiajie Huang, Weilong Zhao, Jinling Ning, Jianing Liu, Jinhui Tian, Long Ge, Kehu Yang","doi":"10.1002/rmv.2523","DOIUrl":"10.1002/rmv.2523","url":null,"abstract":"<p><p>COVID-19 is not only associated with substantial acute liver and kidney injuries, but also with an elevated risk of post-acute sequelae involving the kidney and liver system. We aimed to investigate whether COVID-19 exposure increases the long-term risk of kidney and liver disease, and what are the magnitudes of these associations. We searched PubMed, Embase, Web of Science, ClinicalTrials.gov, and the Living Overview of the Evidence COVID-19 Repository for cohort studies estimating the association between COVID-19 and kidney and liver outcomes. Random-effects meta-analyses were performed to combine the results of the included studies. We assessed the certainty of the evidence using the Grading of Recommendations Assessment, Development and Evaluation approach. Fifteen cohort studies with more than 32 million participants were included in the systematic review COVID-19 was associated with a 35% greater risk of kidney diseases (10 more per 1000 persons; low certainty evidence) and 54% greater risk of liver disease (3 more per 1000 persons; low certainty evidence). The absolute increases due to COVID-19 for acute kidney injury, chronic kidney disease, and liver test abnormality were 3, 8, and 3 per 1000 persons, respectively. Subgroup analyses found no differences between different type of kidney and liver diseases. The findings provide further evidence for the association between COVID-19 and incident kidney and liver conditions. The absolute magnitude of the effect of COVID-19 on kidney and liver outcomes was, however, relatively small.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"34 2","pages":"e2523"},"PeriodicalIF":9.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140176231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ferritin: Significance in viral infections. 铁蛋白:在病毒感染中的意义。
IF 9 2区 医学 Q1 VIROLOGY Pub Date : 2024-03-01 DOI: 10.1002/rmv.2531
Xia Zhao, Yuntao Zhou, Yong Zhang, Yan Zhang

As an indispensable trace element, iron is essential for many biological processes. Increasing evidence has shown that virus infection can perturb iron metabolism and play a role in the occurrence and development of viral infection-related diseases. Ferritin plays a crucial role in maintaining the body's iron homoeostasis. It is an important protein to stabilise the iron balance in cells. Ferritin is a 24-mer hollow iron storage protein composed of two subunits: ferritin heavy chain and ferritin light chain. It was reported that ferritin is not only an intra-cellular iron storage protein, but also a pathogenic mediator that enhances the inflammatory process and stimulates the further inflammatory pathway, which is a key member of the vicious pathogenic cycle to perpetuate. Ferritin exerts immuno-suppressive and pro-inflammatory functions during viral infection. In this review, we describe in detail the basic information of ferritin in the first section, including its structural features, the regulation of ferritin. In the second part, we focus on the role of ferritin in viral infection-related diseases and the molecular mechanisms by which viral infection regulates ferritin. The last section briefly outlines the potential of ferritin in antiviral therapy. Given the importance of iron and viral infection, understanding the role of ferritin during viral infection helps us understand the relationship between iron metabolic dysfunction and viral infection, which provides a new direction for the development of antiviral therapeutic drugs.

作为一种不可或缺的微量元素,铁对许多生物过程都至关重要。越来越多的证据表明,病毒感染会扰乱铁代谢,并在病毒感染相关疾病的发生和发展中发挥作用。铁蛋白在维持人体铁平衡方面发挥着至关重要的作用。它是稳定细胞中铁平衡的重要蛋白质。铁蛋白是一种 24 聚体的中空铁储存蛋白,由两个亚基组成:铁蛋白重链和铁蛋白轻链。据报道,铁蛋白不仅是一种细胞内铁贮存蛋白,还是一种致病介质,能增强炎症过程,刺激炎症通路的进一步发展,是恶性致病循环得以延续的关键成员。铁蛋白在病毒感染过程中发挥免疫抑制和促炎功能。在这篇综述中,我们将在第一部分详细介绍铁蛋白的基本信息,包括其结构特征、铁蛋白的调控。第二部分,我们将重点讨论铁蛋白在病毒感染相关疾病中的作用以及病毒感染调控铁蛋白的分子机制。最后一部分简要概述了铁蛋白在抗病毒治疗中的潜力。鉴于铁与病毒感染的重要性,了解铁蛋白在病毒感染过程中的作用有助于我们理解铁代谢功能障碍与病毒感染之间的关系,这为开发抗病毒治疗药物提供了新的方向。
{"title":"Ferritin: Significance in viral infections.","authors":"Xia Zhao, Yuntao Zhou, Yong Zhang, Yan Zhang","doi":"10.1002/rmv.2531","DOIUrl":"10.1002/rmv.2531","url":null,"abstract":"<p><p>As an indispensable trace element, iron is essential for many biological processes. Increasing evidence has shown that virus infection can perturb iron metabolism and play a role in the occurrence and development of viral infection-related diseases. Ferritin plays a crucial role in maintaining the body's iron homoeostasis. It is an important protein to stabilise the iron balance in cells. Ferritin is a 24-mer hollow iron storage protein composed of two subunits: ferritin heavy chain and ferritin light chain. It was reported that ferritin is not only an intra-cellular iron storage protein, but also a pathogenic mediator that enhances the inflammatory process and stimulates the further inflammatory pathway, which is a key member of the vicious pathogenic cycle to perpetuate. Ferritin exerts immuno-suppressive and pro-inflammatory functions during viral infection. In this review, we describe in detail the basic information of ferritin in the first section, including its structural features, the regulation of ferritin. In the second part, we focus on the role of ferritin in viral infection-related diseases and the molecular mechanisms by which viral infection regulates ferritin. The last section briefly outlines the potential of ferritin in antiviral therapy. Given the importance of iron and viral infection, understanding the role of ferritin during viral infection helps us understand the relationship between iron metabolic dysfunction and viral infection, which provides a new direction for the development of antiviral therapeutic drugs.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"34 2","pages":"e2531"},"PeriodicalIF":9.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140158944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical manifestations of dengue, Zika and chikungunya in the Pacific Islands: A systematic review and meta-analysis. 太平洋岛屿登革热、寨卡病毒和基孔肯雅病毒的临床表现:系统回顾和荟萃分析。
IF 9 2区 医学 Q1 VIROLOGY Pub Date : 2024-03-01 DOI: 10.1002/rmv.2521
Sahil Kharwadkar, Nipun Herath

Dengue, Zika and chikungunya outbreaks pose a significant public health risk to Pacific Island communities. Differential diagnosis is challenging due to overlapping clinical features and limited availability of laboratory diagnostic facilities. There is also insufficient information regarding the complications of these arboviruses, particularly for Zika and chikungunya. We conducted a systematic review and meta-analysis to calculate pooled prevalence estimates with 95% confidence intervals (CI) for the clinical manifestations of dengue, Zika and chikungunya in the Pacific Islands. Based on pooled prevalence estimates, clinical features that may help to differentiate between the arboviruses include headache, haemorrhage and hepatomegaly in dengue; rash, conjunctivitis and peripheral oedema in Zika; and the combination of fever and arthralgia in chikungunya infections. We estimated that the hospitalisation and mortality rates in dengue were 9.90% (95% CI 7.67-12.37) and 0.23% (95% CI 0.16-0.31), respectively. Severe forms of dengue occurred in 1.92% (95% CI 0.72-3.63) of reported cases and 23.23% (95% CI 13.58-34.53) of hospitalised patients. Complications associated with Zika virus included Guillain-Barré syndrome (GBS), estimated to occur in 14.08 (95% CI 11.71-16.66) per 10,000 reported cases, and congenital brain malformations such as microcephaly, particularly with first trimester maternal infection. For chikungunya, the hospitalisation rate was 2.57% (95% CI 1.30-4.25) and the risk of GBS was estimated at 1.70 (95% CI 1.06-2.48) per 10,000 reported cases. Whilst ongoing research is required, this systematic review enhances existing knowledge on the clinical manifestations of dengue, Zika and chikungunya infections and will assist Pacific Island clinicians during future arbovirus outbreaks.

登革热、寨卡病毒和基孔肯雅病毒的爆发对太平洋岛屿社区的公共卫生构成了重大风险。由于临床特征重叠和实验室诊断设施有限,鉴别诊断具有挑战性。有关这些虫媒病毒(尤其是寨卡和基孔肯雅)并发症的信息也不足。我们进行了一项系统回顾和荟萃分析,以计算太平洋岛屿登革热、寨卡和基孔肯雅临床表现的集合流行率估计值及 95% 的置信区间 (CI)。根据汇总的流行率估计值,有助于区分虫媒病毒的临床特征包括:登革热患者的头痛、出血和肝肿大;寨卡患者的皮疹、结膜炎和外周水肿;以及基孔肯雅病毒感染患者的发热和关节痛。我们估计,登革热的住院率和死亡率分别为 9.90% (95% CI 7.67-12.37) 和 0.23% (95% CI 0.16-0.31)。在报告的登革热病例中,有 1.92%(95% CI 0.72-3.63)的患者出现了严重形式的登革热,在住院患者中,有 23.23%(95% CI 13.58-34.53)的患者出现了严重形式的登革热。与寨卡病毒相关的并发症包括吉兰-巴雷综合征(GBS),估计每 10,000 例报告病例中就有 14.08 例(95% CI 11.71-16.66)发生,以及先天性脑畸形(如小头畸形),尤其是孕前三个月的母体感染。基孔肯雅病的住院率为 2.57%(95% CI 1.30-4.25),每 10,000 例报告病例中发生 GBS 的风险估计为 1.70(95% CI 1.06-2.48)。虽然还需要继续开展研究,但这一系统性综述增进了人们对登革热、寨卡和基孔肯雅感染临床表现的现有了解,并将在未来虫媒病毒爆发时为太平洋岛屿的临床医生提供帮助。
{"title":"Clinical manifestations of dengue, Zika and chikungunya in the Pacific Islands: A systematic review and meta-analysis.","authors":"Sahil Kharwadkar, Nipun Herath","doi":"10.1002/rmv.2521","DOIUrl":"10.1002/rmv.2521","url":null,"abstract":"<p><p>Dengue, Zika and chikungunya outbreaks pose a significant public health risk to Pacific Island communities. Differential diagnosis is challenging due to overlapping clinical features and limited availability of laboratory diagnostic facilities. There is also insufficient information regarding the complications of these arboviruses, particularly for Zika and chikungunya. We conducted a systematic review and meta-analysis to calculate pooled prevalence estimates with 95% confidence intervals (CI) for the clinical manifestations of dengue, Zika and chikungunya in the Pacific Islands. Based on pooled prevalence estimates, clinical features that may help to differentiate between the arboviruses include headache, haemorrhage and hepatomegaly in dengue; rash, conjunctivitis and peripheral oedema in Zika; and the combination of fever and arthralgia in chikungunya infections. We estimated that the hospitalisation and mortality rates in dengue were 9.90% (95% CI 7.67-12.37) and 0.23% (95% CI 0.16-0.31), respectively. Severe forms of dengue occurred in 1.92% (95% CI 0.72-3.63) of reported cases and 23.23% (95% CI 13.58-34.53) of hospitalised patients. Complications associated with Zika virus included Guillain-Barré syndrome (GBS), estimated to occur in 14.08 (95% CI 11.71-16.66) per 10,000 reported cases, and congenital brain malformations such as microcephaly, particularly with first trimester maternal infection. For chikungunya, the hospitalisation rate was 2.57% (95% CI 1.30-4.25) and the risk of GBS was estimated at 1.70 (95% CI 1.06-2.48) per 10,000 reported cases. Whilst ongoing research is required, this systematic review enhances existing knowledge on the clinical manifestations of dengue, Zika and chikungunya infections and will assist Pacific Island clinicians during future arbovirus outbreaks.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"34 2","pages":"e2521"},"PeriodicalIF":9.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139716336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulatory role of miRNAs in the human immune and inflammatory response during the infection of SARS-CoV-2 and other respiratory viruses: A comprehensive review. miRNA 在 SARS-CoV-2 和其他呼吸道病毒感染期间人类免疫和炎症反应中的调控作用:综述。
IF 9 2区 医学 Q1 VIROLOGY Pub Date : 2024-03-01 DOI: 10.1002/rmv.2526
Chiranjib Chakraborty, Manojit Bhattacharya, Sang-Soo Lee

miRNAs are single-stranded ncRNAs that act as regulators of different human body processes. Several miRNAs have been noted to control the human immune and inflammatory response during severe acute respiratory infection syndrome (SARS-CoV-2) infection. Similarly, many miRNAs were upregulated and downregulated during different respiratory virus infections. Here, an attempt has been made to capture the regulatory role of miRNAs in the human immune and inflammatory response during the infection of SARS-CoV-2 and other respiratory viruses. Firstly, the role of miRNAs has been depicted in the human immune and inflammatory response during the infection of SARS-CoV-2. In this direction, several significant points have been discussed about SARS-CoV-2 infection, such as the role of miRNAs in human innate immune response; miRNAs and its regulation of granulocytes; the role of miRNAs in macrophage activation and polarisation; miRNAs and neutrophil extracellular trap formation; miRNA-related inflammatory response; and miRNAs association in adaptive immunity. Secondly, the miRNAs landscape has been depicted during human respiratory virus infections such as human coronavirus, respiratory syncytial virus, influenza virus, rhinovirus, and human metapneumovirus. The article will provide more understanding of the miRNA-controlled mechanism of the immune and inflammatory response during COVID-19, which will help more therapeutics discoveries to fight against the future pandemic.

miRNAs 是单链 ncRNAs,是人体不同过程的调节因子。人们注意到,在严重急性呼吸道感染综合征(SARS-CoV-2)感染期间,一些 miRNA 可控制人体免疫和炎症反应。同样,在不同的呼吸道病毒感染过程中,许多 miRNA 上调或下调。本文试图研究 miRNA 在 SARS-CoV-2 和其他呼吸道病毒感染期间对人类免疫和炎症反应的调控作用。首先,我们描绘了 miRNA 在感染 SARS-CoV-2 期间人类免疫和炎症反应中的作用。在这个方向上,讨论了有关 SARS-CoV-2 感染的几个重要观点,如 miRNAs 在人类先天性免疫反应中的作用;miRNAs 及其对粒细胞的调控;miRNAs 在巨噬细胞活化和极化中的作用;miRNAs 与中性粒细胞胞外陷阱的形成;miRNA 相关炎症反应;以及 miRNAs 在适应性免疫中的关联。其次,文章描绘了人类呼吸道病毒(如人类冠状病毒、呼吸道合胞病毒、流感病毒、鼻病毒和人类偏肺病毒)感染过程中的 miRNAs 图谱。这篇文章将使人们对 COVID-19 期间免疫和炎症反应的 miRNA 控制机制有更多的了解,从而有助于发现更多的治疗方法来对抗未来的大流行。
{"title":"Regulatory role of miRNAs in the human immune and inflammatory response during the infection of SARS-CoV-2 and other respiratory viruses: A comprehensive review.","authors":"Chiranjib Chakraborty, Manojit Bhattacharya, Sang-Soo Lee","doi":"10.1002/rmv.2526","DOIUrl":"10.1002/rmv.2526","url":null,"abstract":"<p><p>miRNAs are single-stranded ncRNAs that act as regulators of different human body processes. Several miRNAs have been noted to control the human immune and inflammatory response during severe acute respiratory infection syndrome (SARS-CoV-2) infection. Similarly, many miRNAs were upregulated and downregulated during different respiratory virus infections. Here, an attempt has been made to capture the regulatory role of miRNAs in the human immune and inflammatory response during the infection of SARS-CoV-2 and other respiratory viruses. Firstly, the role of miRNAs has been depicted in the human immune and inflammatory response during the infection of SARS-CoV-2. In this direction, several significant points have been discussed about SARS-CoV-2 infection, such as the role of miRNAs in human innate immune response; miRNAs and its regulation of granulocytes; the role of miRNAs in macrophage activation and polarisation; miRNAs and neutrophil extracellular trap formation; miRNA-related inflammatory response; and miRNAs association in adaptive immunity. Secondly, the miRNAs landscape has been depicted during human respiratory virus infections such as human coronavirus, respiratory syncytial virus, influenza virus, rhinovirus, and human metapneumovirus. The article will provide more understanding of the miRNA-controlled mechanism of the immune and inflammatory response during COVID-19, which will help more therapeutics discoveries to fight against the future pandemic.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"34 2","pages":"e2526"},"PeriodicalIF":9.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140040256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Reviews in Medical Virology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1