Pub Date : 2011-12-01DOI: 10.5223/KJPGN.2011.14.4.393
Yong Wook Lee, J. Shin, Mea-young Chang, J. Y. Kim
Dieulafoy’s lesion is defined as a small mucosal defect overlying an abnormal, large caliber submucosal artery that protrudes through the gastrointestinal mucosa. This lesion is a rare cause of massive upper gastrointestinal bleeding in the pediatric population and extremely rare in neonates. We report a 1-day-old neonate who presented with massive gastrointestinal bleeding caused by a gastric Dieulafoy lesion, which was successfully treated by endoscopic hemoclipping without any complications. (Korean J Pediatr Gastroenterol Nutr 2011; 14: 393∼397)
{"title":"Endoscopic Hemoclipping Treatment for Gastric Dieulafoy Lesion in a Newborn","authors":"Yong Wook Lee, J. Shin, Mea-young Chang, J. Y. Kim","doi":"10.5223/KJPGN.2011.14.4.393","DOIUrl":"https://doi.org/10.5223/KJPGN.2011.14.4.393","url":null,"abstract":"Dieulafoy’s lesion is defined as a small mucosal defect overlying an abnormal, large caliber submucosal artery that protrudes through the gastrointestinal mucosa. This lesion is a rare cause of massive upper gastrointestinal bleeding in the pediatric population and extremely rare in neonates. We report a 1-day-old neonate who presented with massive gastrointestinal bleeding caused by a gastric Dieulafoy lesion, which was successfully treated by endoscopic hemoclipping without any complications. (Korean J Pediatr Gastroenterol Nutr 2011; 14: 393∼397)","PeriodicalId":212346,"journal":{"name":"Korean Journal of Pediatric Gastroenterology and Nutrition","volume":"286 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113966893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-12-01DOI: 10.5223/KJPGN.2011.14.4.385
Ah Reum Kim, C. Hong
Purpose: To evaluate the validity and usefulness of the waist circumference-to-height ratio (WHtR) in screening for metabolic syndrome in Korean adolescents aged 17∼19 years. Methods: Data (body mass index, waist circumference, and height) and blood samples were obtained from adolescents in A University Hospital in 2011. This study included 554 adolescents (176 boys and 378 girls) aged 17∼19 years. Dependent variables were systolic and diastolic blood pressure, fasting blood glucose (FBS), total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C) and low density lipoprotein-cholesterol (LDL-C). Using the Pearson’s correlation analysis and logistic regression analysis, we measured the WHtR against Body mass index (BMI). Results: An assessment was carried out of the ability of the 2 indexes to 1) account for the variability in each metabolic risk factor and 2) correctly identify adolescents with metabolic risk factors. The results revealed that the predictive abilities of the waist-to-height ratio index were better values. The waistto-height ratio showed superior values in predicting concentrat ions of DBP, FBS, TC, TG and LDL-C. However, BMI showed better values in identifying adolescents with high systolic blood pressure and HDL-C. 3) Normal weight adolescents (BMI: 5 th ≤BMI＜85 th percentiles) were divided by WHtR (obesity cutoff value: ≥0.51 in male, ≥0.49 in female). WHtR was better than the BMI index for signaling metabolic risk in the normal-weight adolescents. Conclusion: The WHtR is a better predictor for finding metabolic risk factors in adolescents aged 17∼19 years with normal BMI. The WHtR is proposed as an alternative, convenient measure of screening metabolic syndrome for adolescents aged 17∼19 years independent of age and sex. (Korean J Pediatr Gastroenterol Nutr 2011; 14: 385∼392)
{"title":"Waist-to-height Ratio, a Simple and Practical Index for Screening of Adolescent Metabolic Syndrome Aged 17~19 Years","authors":"Ah Reum Kim, C. Hong","doi":"10.5223/KJPGN.2011.14.4.385","DOIUrl":"https://doi.org/10.5223/KJPGN.2011.14.4.385","url":null,"abstract":"Purpose: To evaluate the validity and usefulness of the waist circumference-to-height ratio (WHtR) in screening for metabolic syndrome in Korean adolescents aged 17∼19 years. Methods: Data (body mass index, waist circumference, and height) and blood samples were obtained from adolescents in A University Hospital in 2011. This study included 554 adolescents (176 boys and 378 girls) aged 17∼19 years. Dependent variables were systolic and diastolic blood pressure, fasting blood glucose (FBS), total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C) and low density lipoprotein-cholesterol (LDL-C). Using the Pearson’s correlation analysis and logistic regression analysis, we measured the WHtR against Body mass index (BMI). Results: An assessment was carried out of the ability of the 2 indexes to 1) account for the variability in each metabolic risk factor and 2) correctly identify adolescents with metabolic risk factors. The results revealed that the predictive abilities of the waist-to-height ratio index were better values. The waistto-height ratio showed superior values in predicting concentrat ions of DBP, FBS, TC, TG and LDL-C. However, BMI showed better values in identifying adolescents with high systolic blood pressure and HDL-C. 3) Normal weight adolescents (BMI: 5 th ≤BMI＜85 th percentiles) were divided by WHtR (obesity cutoff value: ≥0.51 in male, ≥0.49 in female). WHtR was better than the BMI index for signaling metabolic risk in the normal-weight adolescents. Conclusion: The WHtR is a better predictor for finding metabolic risk factors in adolescents aged 17∼19 years with normal BMI. The WHtR is proposed as an alternative, convenient measure of screening metabolic syndrome for adolescents aged 17∼19 years independent of age and sex. (Korean J Pediatr Gastroenterol Nutr 2011; 14: 385∼392)","PeriodicalId":212346,"journal":{"name":"Korean Journal of Pediatric Gastroenterology and Nutrition","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114966939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-12-01DOI: 10.5223/KJPGN.2011.14.4.359
Sung-Won Kim, Jungwon Yoon, S. Jeong
Purpose: We compared the clinical manifestations and prognosis of Henoch-Schonlein Purpura (HSP) in children with and without abdominal pain to investigate the usefulness of endoscopy. Methods: We retrospectively studied 185 HSP inpatients (group A [with abdominal pain] and group N [without abdominal pain]) who had been admitted to the BundangCHA hospital between 2001 and 2010. We compared clinical manifestations, laboratory findings and endoscopic and ultrasonographic findings. Results: Of the 185 children, 112 (60.5%) had abdominal pain and 31 (16.8%) presented with abdominal pain before developing cutaneous purpura. Group A patients were older (6.9±3.5 vs. 5.3±3.3 years), had higher rates of positive results for stool occult blood (53.8%, p＜0.001), and had longer hospital stays (5.2±4.2 vs. 3.6±2.5 days) than group N patients. Group A had a higher frequency of renal involvement than group N on admission (p=0.047). Ultrasonography showed small bowel wall thickening in 31 cases (43.7%) and increased Doppler flow in the bowel wall in 22 cases (31%) in Group A. Upper gastrointestinal endoscopy revealed HSP - related lesions in the stomach (25 cases) and duodenum (19 cases). The second portion of the duodenum was a more common lesion site than the duodenal bulb. Ultrasonography showed abnormalities in 13 of 19 patients with duodenal lesions. Recurrence was more common in Group A. Conclusion: These results suggest that recurrence and renal involvement are more common in HSP patients with abdominal pain. Upper gastrointestinal endoscopy could be a useful diagnostic tool for HSP patients who develop abdominal pain before cutaneous purpura. (Korean J Pediatr Gastroenterol Nutr 2011; 14: 359∼367)
{"title":"Comparison of the Clinical Manifestations and Prognosis of Henoch-Schonlein Purpura in Children with and without Abdominal Pain","authors":"Sung-Won Kim, Jungwon Yoon, S. Jeong","doi":"10.5223/KJPGN.2011.14.4.359","DOIUrl":"https://doi.org/10.5223/KJPGN.2011.14.4.359","url":null,"abstract":"Purpose: We compared the clinical manifestations and prognosis of Henoch-Schonlein Purpura (HSP) in children with and without abdominal pain to investigate the usefulness of endoscopy. Methods: We retrospectively studied 185 HSP inpatients (group A [with abdominal pain] and group N [without abdominal pain]) who had been admitted to the BundangCHA hospital between 2001 and 2010. We compared clinical manifestations, laboratory findings and endoscopic and ultrasonographic findings. Results: Of the 185 children, 112 (60.5%) had abdominal pain and 31 (16.8%) presented with abdominal pain before developing cutaneous purpura. Group A patients were older (6.9±3.5 vs. 5.3±3.3 years), had higher rates of positive results for stool occult blood (53.8%, p＜0.001), and had longer hospital stays (5.2±4.2 vs. 3.6±2.5 days) than group N patients. Group A had a higher frequency of renal involvement than group N on admission (p=0.047). Ultrasonography showed small bowel wall thickening in 31 cases (43.7%) and increased Doppler flow in the bowel wall in 22 cases (31%) in Group A. Upper gastrointestinal endoscopy revealed HSP - related lesions in the stomach (25 cases) and duodenum (19 cases). The second portion of the duodenum was a more common lesion site than the duodenal bulb. Ultrasonography showed abnormalities in 13 of 19 patients with duodenal lesions. Recurrence was more common in Group A. Conclusion: These results suggest that recurrence and renal involvement are more common in HSP patients with abdominal pain. Upper gastrointestinal endoscopy could be a useful diagnostic tool for HSP patients who develop abdominal pain before cutaneous purpura. (Korean J Pediatr Gastroenterol Nutr 2011; 14: 359∼367)","PeriodicalId":212346,"journal":{"name":"Korean Journal of Pediatric Gastroenterology and Nutrition","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127388641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-12-01DOI: 10.5223/KJPGN.2011.14.SUPPL1.S9
Kun-Song Lee
Functional gastrointestinal disorders (FGIDs) are defined as a chronic or recurrent gastrointestinal symptoms not explained by structural or biochemical abnormalities. The Rome II pediatric criteria for FGIDs were announced in 1999. The Rome III criteria, update and revise the pediatric criteria, included FGIDs criteria of infant and toddler to child and adolescent (aged 4 to 18 years). The aerophagia was classified into abdominal pain-related FGIDs in the ROME II criteria. However, cyclic vomiting syndrome and aerophagia, both were classified into vomiting and aerophagia part in the ROME III criteria. We describe the clinical features, diagnostic criteria, and treatments of cyclic vomiting syndrome and aerophaiga among pediatric FGIDs. (Korean J Pediatr Gastroenterol Nutr 2011; 14(Suppl 1): S9∼S18)
{"title":"Clinical Approach to Functional Gastrointestinal Disorders in Children: Revolve Around on Cyclic Vomiting Syndrome and Aerophagia","authors":"Kun-Song Lee","doi":"10.5223/KJPGN.2011.14.SUPPL1.S9","DOIUrl":"https://doi.org/10.5223/KJPGN.2011.14.SUPPL1.S9","url":null,"abstract":"Functional gastrointestinal disorders (FGIDs) are defined as a chronic or recurrent gastrointestinal symptoms not explained by structural or biochemical abnormalities. The Rome II pediatric criteria for FGIDs were announced in 1999. The Rome III criteria, update and revise the pediatric criteria, included FGIDs criteria of infant and toddler to child and adolescent (aged 4 to 18 years). The aerophagia was classified into abdominal pain-related FGIDs in the ROME II criteria. However, cyclic vomiting syndrome and aerophagia, both were classified into vomiting and aerophagia part in the ROME III criteria. We describe the clinical features, diagnostic criteria, and treatments of cyclic vomiting syndrome and aerophaiga among pediatric FGIDs. (Korean J Pediatr Gastroenterol Nutr 2011; 14(Suppl 1): S9∼S18)","PeriodicalId":212346,"journal":{"name":"Korean Journal of Pediatric Gastroenterology and Nutrition","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125419289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-12-01DOI: 10.5223/KJPGN.2011.14.SUPPL1.S25
Jinmoo Heo, D. Song
Childhood chronic abdominal pain usually doesn’t have an organic etiology. It may cause social impairment and emotional distress in children as well as their families. In view of cognitive and behavioral aspect, passive coping style, maladaptive social modeling, and reinforced secondary gain could contribute to the development and maintenance of pediatric somatization. Integrative etiological model includes biological factors due to the enteric sensitization process, psychosocial factors which encompass family influences, psychodevelomental vulnerability, and life event-related stress. These factors interact with each other and manifest as various psychosomatic symptoms. In the treatment of childhood chronic abdominal pain, multimodal treatment program, which includes cognitive behavioral therapeutic methods, emotional support, family education, selective serotonin reuptake inhibitor, and so on, is known to be most effective. (Korean J Pediatr Gastroenterol Nutr 2011; 14(Suppl 1): S25∼S33)
{"title":"Psychosocial Factors and Psychiatric Disorder in Childhood Chronic Abdominal Pain","authors":"Jinmoo Heo, D. Song","doi":"10.5223/KJPGN.2011.14.SUPPL1.S25","DOIUrl":"https://doi.org/10.5223/KJPGN.2011.14.SUPPL1.S25","url":null,"abstract":"Childhood chronic abdominal pain usually doesn’t have an organic etiology. It may cause social impairment and emotional distress in children as well as their families. In view of cognitive and behavioral aspect, passive coping style, maladaptive social modeling, and reinforced secondary gain could contribute to the development and maintenance of pediatric somatization. Integrative etiological model includes biological factors due to the enteric sensitization process, psychosocial factors which encompass family influences, psychodevelomental vulnerability, and life event-related stress. These factors interact with each other and manifest as various psychosomatic symptoms. In the treatment of childhood chronic abdominal pain, multimodal treatment program, which includes cognitive behavioral therapeutic methods, emotional support, family education, selective serotonin reuptake inhibitor, and so on, is known to be most effective. (Korean J Pediatr Gastroenterol Nutr 2011; 14(Suppl 1): S25∼S33)","PeriodicalId":212346,"journal":{"name":"Korean Journal of Pediatric Gastroenterology and Nutrition","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127787112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-12-01DOI: 10.5223/KJPGN.2011.14.4.350
Hye Won Yom
Metabolic syndrome (MetS) is characterized by the clustering of obesity, impaired glucose metabolism, hypertension, and dyslipidemia, and is predictive for development of cardiovascular disease and type 2 diabetes. The high prevalence of MetS is a serious health problem, especially among obese adolescents. Because insulin resistance and obesity play a central role in MetS, treatment of MetS should be primarily focused on improving insulin sensitivity and weight reduction. Nutritional therapy of MetS aims to reduce the intakes of saturated fat and free fructose, and increasing the intakes of dietary fiber, unsaturated fat, and antioxidant nutrients may also be beneficial. (Korean J Pediatr Gastroenterol Nutr 2011; 14: 350∼ 358)
{"title":"Clinical Nutrition Therapy of Metabolic Syndrome in Adolescents","authors":"Hye Won Yom","doi":"10.5223/KJPGN.2011.14.4.350","DOIUrl":"https://doi.org/10.5223/KJPGN.2011.14.4.350","url":null,"abstract":"Metabolic syndrome (MetS) is characterized by the clustering of obesity, impaired glucose metabolism, hypertension, and dyslipidemia, and is predictive for development of cardiovascular disease and type 2 diabetes. The high prevalence of MetS is a serious health problem, especially among obese adolescents. Because insulin resistance and obesity play a central role in MetS, treatment of MetS should be primarily focused on improving insulin sensitivity and weight reduction. Nutritional therapy of MetS aims to reduce the intakes of saturated fat and free fructose, and increasing the intakes of dietary fiber, unsaturated fat, and antioxidant nutrients may also be beneficial. (Korean J Pediatr Gastroenterol Nutr 2011; 14: 350∼ 358)","PeriodicalId":212346,"journal":{"name":"Korean Journal of Pediatric Gastroenterology and Nutrition","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115253465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-12-01DOI: 10.5223/KJPGN.2011.14.SUPPL1.S55
J. Shim
There are few studies of underweight in adolescents in Korea and other developed countries. According to the recent surveillance in Korea, prevalence of underweight in adolescents is lower than those in developing countries, and higher than those in developed countries in Northern Europe. This article reviews the problems, diagnosis, and nutritional support of underweight in adolescents. (Korean J Pediatr Gastroenterol Nutr 2011; 14(Suppl 1): S55∼S60)
{"title":"Underweight in Adolescents","authors":"J. Shim","doi":"10.5223/KJPGN.2011.14.SUPPL1.S55","DOIUrl":"https://doi.org/10.5223/KJPGN.2011.14.SUPPL1.S55","url":null,"abstract":"There are few studies of underweight in adolescents in Korea and other developed countries. According to the recent surveillance in Korea, prevalence of underweight in adolescents is lower than those in developing countries, and higher than those in developed countries in Northern Europe. This article reviews the problems, diagnosis, and nutritional support of underweight in adolescents. (Korean J Pediatr Gastroenterol Nutr 2011; 14(Suppl 1): S55∼S60)","PeriodicalId":212346,"journal":{"name":"Korean Journal of Pediatric Gastroenterology and Nutrition","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114016577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-12-01DOI: 10.5223/KJPGN.2011.14.4.334
J. Moon
Nutritional assessment in adolescents is key to detect major health risks at this age, such as obesity and under nutrition, which continue as adult health risks. Recent epidemiological evidence in Korea has shown that obesity is quite prevalent. Scientific protocols assessing nutritional status should be used in various clinical settings, particularly in hospitals and schools. Recent protocols are typically based on growth charts, calorie calculating equations, and Dietary Reference Intakes in Korea which have been developed through extensive studies. Non-communicable chronic diseases, such as type II diabetes mellitus and atherosclerosis could be ameliorated by intervening in behaviors related to nutrition. (Korean J Pediatr Gastroenterol Nutr 2011; 14: 334∼339)
{"title":"Assessment of Clinical Nutrition Problems in Korean Adolescents","authors":"J. Moon","doi":"10.5223/KJPGN.2011.14.4.334","DOIUrl":"https://doi.org/10.5223/KJPGN.2011.14.4.334","url":null,"abstract":"Nutritional assessment in adolescents is key to detect major health risks at this age, such as obesity and under nutrition, which continue as adult health risks. Recent epidemiological evidence in Korea has shown that obesity is quite prevalent. Scientific protocols assessing nutritional status should be used in various clinical settings, particularly in hospitals and schools. Recent protocols are typically based on growth charts, calorie calculating equations, and Dietary Reference Intakes in Korea which have been developed through extensive studies. Non-communicable chronic diseases, such as type II diabetes mellitus and atherosclerosis could be ameliorated by intervening in behaviors related to nutrition. (Korean J Pediatr Gastroenterol Nutr 2011; 14: 334∼339)","PeriodicalId":212346,"journal":{"name":"Korean Journal of Pediatric Gastroenterology and Nutrition","volume":"357 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131730554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-12-01DOI: 10.5223/KJPGN.2011.14.4.376
E. Seo, Sun Geun Lee, Shin-Hye Kim, M. Park
Purpose: This study was performed to evaluate the distribution of homeostasis model assessment of insulin resistance (HOMA-IR), a surrogate marker of insulin resistance, and its association with metabolic risk factors among Korean adolescents. Methods: This study was based on data from Korean National Health and Nutrition Examination Survey (KNHANES) 2008∼2009. Data from 2,035 adolescents (1,053 boys, 982 girls; aged 10∼19 years) were analyzed. We classified all subjects into four groups, based on the quartiles of HOMA-IR, and the highest quartile group was defined as the group with insulin resistance. We performed multivariate logistic regression analysis to determine the independent risk factors for insulin resistance. Results: The highest quartile values of HOMA-IR representing insulin res istance were 3.4 for boys and 3.6 for girls. Mean body mass index, waist circumference, systolic blood pressure, serum triglyceride, alanine aminotransferase (ALT), fasting glucose and insulin increased, whereas HDL cholesterol decreased with increased HOMA-IR. We found HOMA-IR has significant positive correlation with waist circumference, triglyceride, ALT level and systolic/diastolic blood pressure, while it has negative correlation with HDL-cholesterol level (p＜0.005). Independent predictors (odds ratio) for insulin resistance were elevated ALT (3.53 for boys; 4.04 for girls), central obesity (3.01 for boys; 3.20 for girls), and hypertriglyceridemia (3.03 for boys; 1.94 for girls). Conclusion: Metabolic risk factors were strongly associated with insulin resistance, defined as highest quartile values of HOMA-IR (≥3.4 for boys and ≥3.6 for girls). These values could be useful as a marker of insulin resistance and metabolic risk in Korean adolescents. (Korean J Pediatr Gastroenterol Nutr 2011; 14: 376∼384)
{"title":"HOMA-IR and Its Association with Metabolic Risk Factors among Korean Adolescents","authors":"E. Seo, Sun Geun Lee, Shin-Hye Kim, M. Park","doi":"10.5223/KJPGN.2011.14.4.376","DOIUrl":"https://doi.org/10.5223/KJPGN.2011.14.4.376","url":null,"abstract":"Purpose: This study was performed to evaluate the distribution of homeostasis model assessment of insulin resistance (HOMA-IR), a surrogate marker of insulin resistance, and its association with metabolic risk factors among Korean adolescents. Methods: This study was based on data from Korean National Health and Nutrition Examination Survey (KNHANES) 2008∼2009. Data from 2,035 adolescents (1,053 boys, 982 girls; aged 10∼19 years) were analyzed. We classified all subjects into four groups, based on the quartiles of HOMA-IR, and the highest quartile group was defined as the group with insulin resistance. We performed multivariate logistic regression analysis to determine the independent risk factors for insulin resistance. Results: The highest quartile values of HOMA-IR representing insulin res istance were 3.4 for boys and 3.6 for girls. Mean body mass index, waist circumference, systolic blood pressure, serum triglyceride, alanine aminotransferase (ALT), fasting glucose and insulin increased, whereas HDL cholesterol decreased with increased HOMA-IR. We found HOMA-IR has significant positive correlation with waist circumference, triglyceride, ALT level and systolic/diastolic blood pressure, while it has negative correlation with HDL-cholesterol level (p＜0.005). Independent predictors (odds ratio) for insulin resistance were elevated ALT (3.53 for boys; 4.04 for girls), central obesity (3.01 for boys; 3.20 for girls), and hypertriglyceridemia (3.03 for boys; 1.94 for girls). Conclusion: Metabolic risk factors were strongly associated with insulin resistance, defined as highest quartile values of HOMA-IR (≥3.4 for boys and ≥3.6 for girls). These values could be useful as a marker of insulin resistance and metabolic risk in Korean adolescents. (Korean J Pediatr Gastroenterol Nutr 2011; 14: 376∼384)","PeriodicalId":212346,"journal":{"name":"Korean Journal of Pediatric Gastroenterology and Nutrition","volume":"9 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134124323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-12-01DOI: 10.5223/KJPGN.2011.14.4.325
K. Moon
With an uncontrollable amount of energy dense food engulfing children’s life today, no child is completely protected against being overweight or obese. An inordinate intake of energy dense food and lack of physical activity have resulted in a higher rate of obesity in children. In order to combat the seemingly intractable problem, various preventive measures against childhood obesity have been suggested and are currently in effect. It is imperative to evaluate the methodology and potential impact of published obesity-prevention programs, that focus primarily on home, school, and health care environments. (Korean J Pediatr Gastroenterol Nutr 2011; 14: 325∼333)
{"title":"A Comprehensive Review of Obesity Prevention in Children and Adolescents","authors":"K. Moon","doi":"10.5223/KJPGN.2011.14.4.325","DOIUrl":"https://doi.org/10.5223/KJPGN.2011.14.4.325","url":null,"abstract":"With an uncontrollable amount of energy dense food engulfing children’s life today, no child is completely protected against being overweight or obese. An inordinate intake of energy dense food and lack of physical activity have resulted in a higher rate of obesity in children. In order to combat the seemingly intractable problem, various preventive measures against childhood obesity have been suggested and are currently in effect. It is imperative to evaluate the methodology and potential impact of published obesity-prevention programs, that focus primarily on home, school, and health care environments. (Korean J Pediatr Gastroenterol Nutr 2011; 14: 325∼333)","PeriodicalId":212346,"journal":{"name":"Korean Journal of Pediatric Gastroenterology and Nutrition","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115709878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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