Pub Date : 2024-01-20DOI: 10.36348/sjmps.2024.v10i01.005
Hassan L. G., Umar K. J., Yusuf A. J., Rabah A. B., Umar A. U.
The escalating trend of microbial resistance has become a pressing global concern, challenging the effectiveness of antimicrobial agents in treating infections. This study was aimed at evaluating the antimicrobial activity of the n-hexane, ethyl acetate, and methanol extracts of Securidaca longipedunculata against selected human pathogens. The antimicrobial screening against bacterial pathogens- (e.g., Methicillin-resistant staphylococcus aureus, Vancomycin-resistant Enterococci, Staphylococcus aureus, Staphylococcus feacalis, Escherichia coli, Salmonella typhimurium, Pseudomans fluorescens and Klebsiella pneumonieae) and fungal pathogens (which includes Candida albicans, Candida krusei, Aspergillus niger, Aspergillus fumigates, and Microsporum canis) was performed using agar well diffusion and broth dilution methods. The results demonstrated significant antimicrobial activity, with higher efficacy against S. aureus. Susceptibility test results showed that the extract inhibited the growth of all the test organisms (bacteria and fungi) with a mean zone of inhibition range of 18-29 mm, with the exception of VRE, S. typhimurium, P. fluorescens, C. krusei and M. canis in all the three extracts, while Hexane extract showed no inhibition against E. coli and A. niger. The standard drugs sparfloxacin and ciprofloxacin (500 µg/cm3) had zone of inhibition ranging from 28 - 40 mm. While the antifungal drugs fluconazole and fulcin exhibited zone of inhibition ranging from 27 mm to 34 mm. The Minimum inhibitory concentration (MIC) for the extracts ranges from 62.5 - 250µg/cm3, while the Minimum Bactericidal/Fungicidal Concentrations (MBC/MFC) range from 250 - 500 µg/cm3, respectively. The ethyl acetate extracts possessed higher antimicrobial activity among the three extracts tested against S. Aureus. The findings suggest that S. longipedunculata leaves hold promise as a natural source of antimicrobial agents, warranting further exploration for potential therapeutic applications.
{"title":"Comparative Antimicrobial Activity of Securidaca longipedunculata (Fresen) Extracts on Selected Human Pathogens","authors":"Hassan L. G., Umar K. J., Yusuf A. J., Rabah A. B., Umar A. U.","doi":"10.36348/sjmps.2024.v10i01.005","DOIUrl":"https://doi.org/10.36348/sjmps.2024.v10i01.005","url":null,"abstract":"The escalating trend of microbial resistance has become a pressing global concern, challenging the effectiveness of antimicrobial agents in treating infections. This study was aimed at evaluating the antimicrobial activity of the n-hexane, ethyl acetate, and methanol extracts of Securidaca longipedunculata against selected human pathogens. The antimicrobial screening against bacterial pathogens- (e.g., Methicillin-resistant staphylococcus aureus, Vancomycin-resistant Enterococci, Staphylococcus aureus, Staphylococcus feacalis, Escherichia coli, Salmonella typhimurium, Pseudomans fluorescens and Klebsiella pneumonieae) and fungal pathogens (which includes Candida albicans, Candida krusei, Aspergillus niger, Aspergillus fumigates, and Microsporum canis) was performed using agar well diffusion and broth dilution methods. The results demonstrated significant antimicrobial activity, with higher efficacy against S. aureus. Susceptibility test results showed that the extract inhibited the growth of all the test organisms (bacteria and fungi) with a mean zone of inhibition range of 18-29 mm, with the exception of VRE, S. typhimurium, P. fluorescens, C. krusei and M. canis in all the three extracts, while Hexane extract showed no inhibition against E. coli and A. niger. The standard drugs sparfloxacin and ciprofloxacin (500 µg/cm3) had zone of inhibition ranging from 28 - 40 mm. While the antifungal drugs fluconazole and fulcin exhibited zone of inhibition ranging from 27 mm to 34 mm. The Minimum inhibitory concentration (MIC) for the extracts ranges from 62.5 - 250µg/cm3, while the Minimum Bactericidal/Fungicidal Concentrations (MBC/MFC) range from 250 - 500 µg/cm3, respectively. The ethyl acetate extracts possessed higher antimicrobial activity among the three extracts tested against S. Aureus. The findings suggest that S. longipedunculata leaves hold promise as a natural source of antimicrobial agents, warranting further exploration for potential therapeutic applications.","PeriodicalId":21367,"journal":{"name":"Saudi Journal of Medical and Pharmaceutical Sciences","volume":"55 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139611681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-17DOI: 10.36348/sjmps.2024.v10i01.004
M. Azizi, Ali El Khand, Rabiaa Bounabe, A. Sobhi, Y. Zajjari, A. Alayoud, Souhail Mouline
Thrombotic Thrombocytopenic Purpura is a potentially fatal disease that can be life-threatening. The association with Sjogren’s syndrome is rare entity that deserves special attention. To this end, we report the case of a Thrombotic thrombocytopenic purpura complicating secondary Sjögren's syndrome. This is a 49-year-old patient with a history of pure nephrotic syndrome with minimal glomerular lesions (LGM), who developed Sjögren's syndrome two years later. The diagnosis of Sjögren's syndrome was retained with an etiological investigation suggesting SS secondary to SLE systemic lupus erythematosus. Six months after the diagnosis of secondary SS, the patient was admitted with headache, ecchymotic and petechial lesions on the upper limbs. The laboratory analysis revealed severe thrombocytopenia, haemolytic anemia with a schizocyte count at 6% supporting the diagnosis of thrombotic microangiopathy. The ADAMTS 13 activity assay was less than 5% and the anti-ADAMTS 13 antibody test was positive, attesting thus, the diagnosis of acquired TTP complicating SS secondary to SLE. The patient received an emergency blood transfusion of fresh frozen plasma combined with corticosteroid therapy and mycophenolate mofetil. The clinico-biological outcome, at 6 month and 1 year, was favorable with complete remission. To the best of our knowledge, this is the first case report of TTP complicating Sjögren’s syndrome in Africa. It highlights the rarity of association between autoimmune disease particulary Sjögren’s syndrome and TTP.
{"title":"Thrombotic Thrombocytopenic Purpura Complicating Secondary Sjögren's Syndrome: A Rare and Serious Association from Africa","authors":"M. Azizi, Ali El Khand, Rabiaa Bounabe, A. Sobhi, Y. Zajjari, A. Alayoud, Souhail Mouline","doi":"10.36348/sjmps.2024.v10i01.004","DOIUrl":"https://doi.org/10.36348/sjmps.2024.v10i01.004","url":null,"abstract":"Thrombotic Thrombocytopenic Purpura is a potentially fatal disease that can be life-threatening. The association with Sjogren’s syndrome is rare entity that deserves special attention. To this end, we report the case of a Thrombotic thrombocytopenic purpura complicating secondary Sjögren's syndrome. This is a 49-year-old patient with a history of pure nephrotic syndrome with minimal glomerular lesions (LGM), who developed Sjögren's syndrome two years later. The diagnosis of Sjögren's syndrome was retained with an etiological investigation suggesting SS secondary to SLE systemic lupus erythematosus. Six months after the diagnosis of secondary SS, the patient was admitted with headache, ecchymotic and petechial lesions on the upper limbs. The laboratory analysis revealed severe thrombocytopenia, haemolytic anemia with a schizocyte count at 6% supporting the diagnosis of thrombotic microangiopathy. The ADAMTS 13 activity assay was less than 5% and the anti-ADAMTS 13 antibody test was positive, attesting thus, the diagnosis of acquired TTP complicating SS secondary to SLE. The patient received an emergency blood transfusion of fresh frozen plasma combined with corticosteroid therapy and mycophenolate mofetil. The clinico-biological outcome, at 6 month and 1 year, was favorable with complete remission. To the best of our knowledge, this is the first case report of TTP complicating Sjögren’s syndrome in Africa. It highlights the rarity of association between autoimmune disease particulary Sjögren’s syndrome and TTP.","PeriodicalId":21367,"journal":{"name":"Saudi Journal of Medical and Pharmaceutical Sciences","volume":"31 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139527249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-13DOI: 10.36348/sjmps.2024.v10i01.003
Anil Batta
A plethora of research has implicated hundreds of putative biomarkers for depression but has not yet fully elucidated their roles in depressive illness or established what is abnormal in which patients and how biologic information can be used to enhance diagnosis, treatment, and prognosis. This lack of progress is partially due to the nature and heterogeneity of depression, in conjunction with methodological heterogeneity within the research literature and the large array of biomarkers with potential, the expression of which often varies according to many factors. We review the available literature, which indicates that markers involved in inflammatory, neurotrophic, and metabolic processes, as well as neurotransmitter and neuroendocrine system components, represent highly promising candidates. These may be measured through genetic and epigenetic, transcriptomic and proteomic, metabolomic, and neuroimaging assessments. The use of novel approaches and systematic research programs is now required to determine whether, and which, biomarkers can be used to predict response to treatment, stratify patients to specific treatments, and develop targets for new interventions. We conclude that there is much promise for reducing the burden of depression through further developing and expanding these research avenues.
{"title":"Biomarkers for Depression: A Detailed View","authors":"Anil Batta","doi":"10.36348/sjmps.2024.v10i01.003","DOIUrl":"https://doi.org/10.36348/sjmps.2024.v10i01.003","url":null,"abstract":"A plethora of research has implicated hundreds of putative biomarkers for depression but has not yet fully elucidated their roles in depressive illness or established what is abnormal in which patients and how biologic information can be used to enhance diagnosis, treatment, and prognosis. This lack of progress is partially due to the nature and heterogeneity of depression, in conjunction with methodological heterogeneity within the research literature and the large array of biomarkers with potential, the expression of which often varies according to many factors. We review the available literature, which indicates that markers involved in inflammatory, neurotrophic, and metabolic processes, as well as neurotransmitter and neuroendocrine system components, represent highly promising candidates. These may be measured through genetic and epigenetic, transcriptomic and proteomic, metabolomic, and neuroimaging assessments. The use of novel approaches and systematic research programs is now required to determine whether, and which, biomarkers can be used to predict response to treatment, stratify patients to specific treatments, and develop targets for new interventions. We conclude that there is much promise for reducing the burden of depression through further developing and expanding these research avenues.","PeriodicalId":21367,"journal":{"name":"Saudi Journal of Medical and Pharmaceutical Sciences","volume":" 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139623710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-04DOI: 10.36348/sjmps.2024.v10i01.002
M. Bouissehak, M. Kadiri, M. Borahma, F. Chabib, C. Berhili, N. Lagdali, I. Benelbardhadi, F. Ajana
Background: Severe acute pancreatitis (SAP) is associated with high morbidity and mortality due to the development of pancreatic and an infection that follows extra-pancreatic necrosis, and multisystem organ failure (MOF). Objective: To determine the value of jejunal tube in the treatment of severe acute pancreatitis. Methods: A cross-sectional study was conducted at Saidu group of teaching hospitals, Saidu Sharif Swat, Pakistan, which was performed between July 2020 and March 2022, The total number of patients in our study were 112. The number of Male patients were 33 and female were 79. In 112 consecutive patients who underwent for blood tests and Procedures. We did CT scan for all patients to determine the grade of pancreatitis. Data was tabulated and analyzed by SPSS. Results: In a current study total of 112 patients were enrolled with mean±SD age of 52.61±5.54 years. The maximum age were 61 and minimum ages were 41. The mean±SD of serum lipase were 639.56±209.9. The maximum serium lipase were 1107 and minimum serium lipase were 299. The mean±SD of time of patients recovery were 5.96±1.09. The maximum time of patients recovery were 10 and minimum time of patients recovery were 5. The mean±SD of recovery days were 5.63±0.78. The maximum recovery days of patients were 9 and minimum recovery time were 5. Bar graph showing gender distribution in which females patients were 79 and males patients were 33. In this graph females patients were more as compared to males patients. The number of patients with abdominal pain were 109. The number of patients came to hospital with nausea were 86. The number of patients present with vomiting were 26. The patients who have gall stone were 51. The effectivenss of J-Tube in patients were 33. The complication were noted in 4 patients and the jejunal Tube were pass to 36 patients. Mild pancreatitis patients were 22%, moderate pancreatitis patients were 48% and severe pancreatitis patients were 30%. Conclusion: The recovery time of patients from severe acute pancreatitis was 5 to 10 days. Jejunal tube is more effective in the patients who has more vomiting in severe acute pancreatitis. Jejunal tube is pass to the patient as soon as possible when patient is diagnose with sever acute pancreatitis. In severe acute pancreatitis patients have more vomiting and abdominal pain. We can diagnose patient of sever acute pancreatitis on Serium lipase blood test. In our study females were more as compare to males.
{"title":"Etiological, Therapeutic and Evolutionary Profile of Budd Chiari Syndrome (BCS): A Moroccan Experience Center","authors":"M. Bouissehak, M. Kadiri, M. Borahma, F. Chabib, C. Berhili, N. Lagdali, I. Benelbardhadi, F. Ajana","doi":"10.36348/sjmps.2024.v10i01.002","DOIUrl":"https://doi.org/10.36348/sjmps.2024.v10i01.002","url":null,"abstract":"Background: Severe acute pancreatitis (SAP) is associated with high morbidity and mortality due to the development of pancreatic and an infection that follows extra-pancreatic necrosis, and multisystem organ failure (MOF). Objective: To determine the value of jejunal tube in the treatment of severe acute pancreatitis. Methods: A cross-sectional study was conducted at Saidu group of teaching hospitals, Saidu Sharif Swat, Pakistan, which was performed between July 2020 and March 2022, The total number of patients in our study were 112. The number of Male patients were 33 and female were 79. In 112 consecutive patients who underwent for blood tests and Procedures. We did CT scan for all patients to determine the grade of pancreatitis. Data was tabulated and analyzed by SPSS. Results: In a current study total of 112 patients were enrolled with mean±SD age of 52.61±5.54 years. The maximum age were 61 and minimum ages were 41. The mean±SD of serum lipase were 639.56±209.9. The maximum serium lipase were 1107 and minimum serium lipase were 299. The mean±SD of time of patients recovery were 5.96±1.09. The maximum time of patients recovery were 10 and minimum time of patients recovery were 5. The mean±SD of recovery days were 5.63±0.78. The maximum recovery days of patients were 9 and minimum recovery time were 5. Bar graph showing gender distribution in which females patients were 79 and males patients were 33. In this graph females patients were more as compared to males patients. The number of patients with abdominal pain were 109. The number of patients came to hospital with nausea were 86. The number of patients present with vomiting were 26. The patients who have gall stone were 51. The effectivenss of J-Tube in patients were 33. The complication were noted in 4 patients and the jejunal Tube were pass to 36 patients. Mild pancreatitis patients were 22%, moderate pancreatitis patients were 48% and severe pancreatitis patients were 30%. Conclusion: The recovery time of patients from severe acute pancreatitis was 5 to 10 days. Jejunal tube is more effective in the patients who has more vomiting in severe acute pancreatitis. Jejunal tube is pass to the patient as soon as possible when patient is diagnose with sever acute pancreatitis. In severe acute pancreatitis patients have more vomiting and abdominal pain. We can diagnose patient of sever acute pancreatitis on Serium lipase blood test. In our study females were more as compare to males.","PeriodicalId":21367,"journal":{"name":"Saudi Journal of Medical and Pharmaceutical Sciences","volume":"90 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139630521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-02DOI: 10.36348/sjmps.2024.v10i01.001
Skarma Choton, J. Bandral, Jagmohan Singh, A. Bhat, Monika Sood, Neeraj Gupta, Monica Reshi, Damanpreet Kaur
Starch is the most abundant naturally occurring carbohydrate reserve in plants and is found in cereals, roots, tubers, legumes and some immature fruits like bananas or mangos. Starch is usually employed as a food additive, such as a thickening, stabilizer, or texture enhancer to improve some of the products quality characteristics, pharmaceutical and among other. The application of native starch is often restricted owing to its constricted solubility, weak functional attributes and limited tolerance to a wide array of processing conditions. Its low resistance to shear, high retrogradation, and poor freeze-thaw stability, limit the use of starch in industrial applications. These natural shortcomings can be overcome by different methods of modification. In recent decades, enzymatic modifications have been adopted, partly replacing the chemical and physical methods for the preparation of modified starch, as enzymes are safer and healthier than chemical method for both the environment and food consumers. Several enzymes viz., alfa-amylase, beta-amylase, glucose isomerase, pullulanase, xylanase, among others are use in modification of starch. The enzymatic modification of starch molecules directly affected properties of the modified starch especially in freeze-thaw stability of gels and retardation of retrogradation during storage. Combined enzymatic modification resulted in a marked increase in resistant starch and enzyme modified starch can be well utilized as a fat replacer. It is environment-friendly method and can provide desired functional characteristics.
{"title":"Enzymatic Modification of Starch: A Review","authors":"Skarma Choton, J. Bandral, Jagmohan Singh, A. Bhat, Monika Sood, Neeraj Gupta, Monica Reshi, Damanpreet Kaur","doi":"10.36348/sjmps.2024.v10i01.001","DOIUrl":"https://doi.org/10.36348/sjmps.2024.v10i01.001","url":null,"abstract":"Starch is the most abundant naturally occurring carbohydrate reserve in plants and is found in cereals, roots, tubers, legumes and some immature fruits like bananas or mangos. Starch is usually employed as a food additive, such as a thickening, stabilizer, or texture enhancer to improve some of the products quality characteristics, pharmaceutical and among other. The application of native starch is often restricted owing to its constricted solubility, weak functional attributes and limited tolerance to a wide array of processing conditions. Its low resistance to shear, high retrogradation, and poor freeze-thaw stability, limit the use of starch in industrial applications. These natural shortcomings can be overcome by different methods of modification. In recent decades, enzymatic modifications have been adopted, partly replacing the chemical and physical methods for the preparation of modified starch, as enzymes are safer and healthier than chemical method for both the environment and food consumers. Several enzymes viz., alfa-amylase, beta-amylase, glucose isomerase, pullulanase, xylanase, among others are use in modification of starch. The enzymatic modification of starch molecules directly affected properties of the modified starch especially in freeze-thaw stability of gels and retardation of retrogradation during storage. Combined enzymatic modification resulted in a marked increase in resistant starch and enzyme modified starch can be well utilized as a fat replacer. It is environment-friendly method and can provide desired functional characteristics.","PeriodicalId":21367,"journal":{"name":"Saudi Journal of Medical and Pharmaceutical Sciences","volume":"114 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139390900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-21DOI: 10.36348/sjmps.2023.v09i12.012
Da Qing, Doctor Sadia Hassan, Guzhali Nuer • Nizhamu, Doctor Maiherefu Guli • Wufuer, Muredili. Mutalifu
Objective to explore the clinical efficacy of low-temperature plasma tonsillectomy in the treatment of patients with chronic tonsillitis and tonsillar hypertrophy. Methods: 100 patients with chronic tonsillitis and tonsillar hypertrophy admitted to the first affiliated hospital of Xinjiang Medical University from August 2021 to August 2023 were randomly selected as the research subjects. Based on the voluntary principle and different treatment plans, The patients were divided into two groups. 50 patients who underwent dissection tonsillectomy treatment were selected into the control group, and 50 patients who underwent low-temperature plasma tonsillectomy were selected into the observation group. The differences in clinical indicators between the two groups of patients were compared, The pain levels of patients at different postoperative periods were evaluated, and the differences in serum inflammatory factor levels were detected. Results: Compared with the control group, after surgical treatment, the operation time, and intra-operative bleeding volume of the blood observation group were significantly shorter, and the difference was statistically significant (P<0.05); 1, 3, 5 and 7 days after surgery in the observation group. The Visual analogue scale VAS pain scores at 7 days were lower than those in the control group, and the difference was statistically significant (P<0.05); after surgery in the observation group, the patient's high-sensitivity C-reactive protein (hs-CRP) (14.18±0.51) mg/L, Tumor necrotic factor-alpha (TNF-α) (4.23±0.31) pg/ml was significantly less, and the difference was statistically significant (P<0.05); 5 patients in the observation group suffered from postoperative bleeding and complications The incidence rate was 16.00%, which was significantly lower than that of the control group, and the difference was statistically significant (χ2=4.588, P<0.05). Conclusion: From our study it was able to show that tonsillectomy for adults and children with recurrent tonsillitis were widely used which improves health and quality of life and reduces the need to consume medical resources. When low-temperature plasma tonsillectomy is used in the clinical treatment of patients with chronic tonsillitis and tonsillar hypertrophy, the inoperative blood loss of the patients is significantly reduced, the clinical pain of the patients is further relieved, and the serum inflammatory factor levels of the patients are adjusted.
{"title":"At Low Temperature Plasma Preoperative and Postoperative of Chronic Tonsillitis Tonsillectomy Farhan Ahmad, Professor Yalikun Ya Sheng, Assistant Professor Nilipaer Alimu, Senior Doctor Zhong","authors":"Da Qing, Doctor Sadia Hassan, Guzhali Nuer • Nizhamu, Doctor Maiherefu Guli • Wufuer, Muredili. Mutalifu","doi":"10.36348/sjmps.2023.v09i12.012","DOIUrl":"https://doi.org/10.36348/sjmps.2023.v09i12.012","url":null,"abstract":"Objective to explore the clinical efficacy of low-temperature plasma tonsillectomy in the treatment of patients with chronic tonsillitis and tonsillar hypertrophy. Methods: 100 patients with chronic tonsillitis and tonsillar hypertrophy admitted to the first affiliated hospital of Xinjiang Medical University from August 2021 to August 2023 were randomly selected as the research subjects. Based on the voluntary principle and different treatment plans, The patients were divided into two groups. 50 patients who underwent dissection tonsillectomy treatment were selected into the control group, and 50 patients who underwent low-temperature plasma tonsillectomy were selected into the observation group. The differences in clinical indicators between the two groups of patients were compared, The pain levels of patients at different postoperative periods were evaluated, and the differences in serum inflammatory factor levels were detected. Results: Compared with the control group, after surgical treatment, the operation time, and intra-operative bleeding volume of the blood observation group were significantly shorter, and the difference was statistically significant (P<0.05); 1, 3, 5 and 7 days after surgery in the observation group. The Visual analogue scale VAS pain scores at 7 days were lower than those in the control group, and the difference was statistically significant (P<0.05); after surgery in the observation group, the patient's high-sensitivity C-reactive protein (hs-CRP) (14.18±0.51) mg/L, Tumor necrotic factor-alpha (TNF-α) (4.23±0.31) pg/ml was significantly less, and the difference was statistically significant (P<0.05); 5 patients in the observation group suffered from postoperative bleeding and complications The incidence rate was 16.00%, which was significantly lower than that of the control group, and the difference was statistically significant (χ2=4.588, P<0.05). Conclusion: From our study it was able to show that tonsillectomy for adults and children with recurrent tonsillitis were widely used which improves health and quality of life and reduces the need to consume medical resources. When low-temperature plasma tonsillectomy is used in the clinical treatment of patients with chronic tonsillitis and tonsillar hypertrophy, the inoperative blood loss of the patients is significantly reduced, the clinical pain of the patients is further relieved, and the serum inflammatory factor levels of the patients are adjusted.","PeriodicalId":21367,"journal":{"name":"Saudi Journal of Medical and Pharmaceutical Sciences","volume":"13 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139167231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Breast cancer presents a complex clinical scenario requiring multifaceted approaches for effective management. Objective: The primary objective is to analyze the Clinical status of Ocular Manifestations in Breast Cancer Patients. Method: A cross-sectional study was conducted involving 45 breast cancer patients. Data on age distribution, educational qualifications, socio-economic status, disease staging, primary treatment methods, and ocular manifestations were collected and analyzed to determine demographic trends and disease characteristics. Results: The study revealed a diverse demographic representation across age groups, with a notable concentration between 41 and 60 years. Educational qualifications and socio-economic statuses exhibited varied distributions. Disease staging indicated a significant prevalence of advanced stages (II and III), while diverse treatment modalities, primarily mastectomy and segmental resection, were employed. Ocular manifestations, although relatively infrequent at 11.10%, underscored the importance of vigilant monitoring. Conclusion: The findings highlight the multifaceted nature of breast cancer patient profiles and disease characteristics. Tailored approaches are warranted considering diverse patient demographics and disease stages. Enhanced early detection strategies and personalized treatment plans are imperative to optimize breast cancer care. The recognition and surveillance of ocular manifestations emphasize the need for comprehensive patient monitoring. Altogether, this study underscores the significance of personalized, comprehensive care strategies in breast cancer management to improve patient outcomes and well-being.
{"title":"The Clinical Status of Ocular Manifestations in Breast Cancer Patients","authors":"Masudul Hasan, Jamsed Faridi, Md. Mahfujullah Md. Mahfujullah, Md Farzad Fujail Ibne Amin, Md. Hasanuzzaman Md. Hasanuzzaman, Md Adnan Islam","doi":"10.36348/sjmps.2023.v09i12.011","DOIUrl":"https://doi.org/10.36348/sjmps.2023.v09i12.011","url":null,"abstract":"Background: Breast cancer presents a complex clinical scenario requiring multifaceted approaches for effective management. Objective: The primary objective is to analyze the Clinical status of Ocular Manifestations in Breast Cancer Patients. Method: A cross-sectional study was conducted involving 45 breast cancer patients. Data on age distribution, educational qualifications, socio-economic status, disease staging, primary treatment methods, and ocular manifestations were collected and analyzed to determine demographic trends and disease characteristics. Results: The study revealed a diverse demographic representation across age groups, with a notable concentration between 41 and 60 years. Educational qualifications and socio-economic statuses exhibited varied distributions. Disease staging indicated a significant prevalence of advanced stages (II and III), while diverse treatment modalities, primarily mastectomy and segmental resection, were employed. Ocular manifestations, although relatively infrequent at 11.10%, underscored the importance of vigilant monitoring. Conclusion: The findings highlight the multifaceted nature of breast cancer patient profiles and disease characteristics. Tailored approaches are warranted considering diverse patient demographics and disease stages. Enhanced early detection strategies and personalized treatment plans are imperative to optimize breast cancer care. The recognition and surveillance of ocular manifestations emphasize the need for comprehensive patient monitoring. Altogether, this study underscores the significance of personalized, comprehensive care strategies in breast cancer management to improve patient outcomes and well-being.","PeriodicalId":21367,"journal":{"name":"Saudi Journal of Medical and Pharmaceutical Sciences","volume":"249 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139169912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-13DOI: 10.36348/sjmps.2023.v09i12.010
Amer Mohammed L Alanazi, Ashwaq Mohammed L Alanazi, Samiyah Mohammed L Alanazi, Salem Sufuq M Alanazi
Background: Researchers now have unprecedented access to low-latency data at affordable prices thanks to social media's widespread acceptance and continuous use. Given how often food is discussed and uploaded on social media, nutrition research may find this to be of special interest. Objectives: To summarize current published evidence on the impact of social media on fast food consumption and increased bad nutritional habits. Methods: PubMed, SCOPUS, Web of Science, and Science Direct were systematically searched for relevant literature. Rayyan QRCI was employed throughout this comprehensive process. Results & Interpretation: We included six studies with a total of 10988 participants, and 5899 (53.7%) were females. The reported rate of using social media ranged from 72.9% [15] to 95.9% [17]. The average daily usage of social media and the choices and behaviours related to fast food were found to be strongly correlated. The activity that most negatively impacted children's eating habits was watching food videos. Due to the previously identified connections between conventional forms of food marketing and children's eating habits, food marketing is controlled or prohibited in the majority of Western nations. In general, social media has a negative impact on people's relationship with food and how they view their bodies.
背景：由于社交媒体被广泛接受和持续使用，研究人员现在可以前所未有地以可承受的价格获取低延迟数据。鉴于在社交媒体上讨论和上传食物的频率很高，营养学研究可能会对此特别感兴趣。研究目标总结目前已发表的关于社交媒体对快餐消费和不良营养习惯增加的影响的证据。研究方法系统检索了 PubMed、SCOPUS、Web of Science 和 Science Direct 中的相关文献。在整个综合过程中采用了 Rayyan QRCI。结果与解释：我们纳入了六项研究，共有 10988 名参与者，其中女性 5899 人（53.7%）。报告的社交媒体使用率从 72.9% [15] 到 95.9% [17]不等。研究发现，社交媒体的日均使用率与快餐相关的选择和行为密切相关。对儿童饮食习惯影响最大的活动是观看美食视频。由于之前发现的传统形式的食品营销与儿童饮食习惯之间的联系，大多数西方国家都控制或禁止食品营销。总的来说，社交媒体对人们与食物的关系以及他们如何看待自己的身体产生了负面影响。
{"title":"Impact of Social Media on Fast Food Consumption and Increased Bad Nutritional Habits: Systematic Review","authors":"Amer Mohammed L Alanazi, Ashwaq Mohammed L Alanazi, Samiyah Mohammed L Alanazi, Salem Sufuq M Alanazi","doi":"10.36348/sjmps.2023.v09i12.010","DOIUrl":"https://doi.org/10.36348/sjmps.2023.v09i12.010","url":null,"abstract":"Background: Researchers now have unprecedented access to low-latency data at affordable prices thanks to social media's widespread acceptance and continuous use. Given how often food is discussed and uploaded on social media, nutrition research may find this to be of special interest. Objectives: To summarize current published evidence on the impact of social media on fast food consumption and increased bad nutritional habits. Methods: PubMed, SCOPUS, Web of Science, and Science Direct were systematically searched for relevant literature. Rayyan QRCI was employed throughout this comprehensive process. Results & Interpretation: We included six studies with a total of 10988 participants, and 5899 (53.7%) were females. The reported rate of using social media ranged from 72.9% [15] to 95.9% [17]. The average daily usage of social media and the choices and behaviours related to fast food were found to be strongly correlated. The activity that most negatively impacted children's eating habits was watching food videos. Due to the previously identified connections between conventional forms of food marketing and children's eating habits, food marketing is controlled or prohibited in the majority of Western nations. In general, social media has a negative impact on people's relationship with food and how they view their bodies.","PeriodicalId":21367,"journal":{"name":"Saudi Journal of Medical and Pharmaceutical Sciences","volume":"10 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139181874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-12DOI: 10.36348/sjmps.2023.v09i12.008
Omer Mohammed L Alanazi, Rahf Mohammed L Alenezi, Shahd Saud S Alenezi, Afaf. Alruwaili
Background: One of the most serious acute metabolic complications of type 1 diabetes (T1D) is diabetic ketoacidosis (DKA), which is characterised by acidosis, ketosis, and frequently hyperglycemia. Objectives: To summarize the recent epidemiological data and risk factors for developing DKA in adult T1D patients. Methods: PubMed, SCOPUS, Web of Science, and Science Direct were systematically searched for relevant literature. Rayyan QRCI was employed throughout this comprehensive process. Results & interpretation: We included eleven studies with a total of 104388 participants, and 52733 (50.5%) were males. The incidence of DKA in patients with T1D ranged from 2% to 64.8%. Risk factors for developing DKA included non-adherence, alcohol, higher HbA1c levels, longer-term diabetes, teenage age group, female gender, associated comorbid conditions, and intake of fat and carbohydrates. It's interesting to note that despair, drug misuse, and social deprivation are prevalent among DKA patients who are admitted. Consuming fibre and using freeStyle Libre protected T1D patients from developing DKA. Future research is obviously needed to provide a more comprehensive description of the epidemiology of DKA among adult T1D patients.
{"title":"Updates on Incidence and Risk Factors of Diabetic Ketoacidosis among Adults with Type 1 Diabetes: Systematic Review","authors":"Omer Mohammed L Alanazi, Rahf Mohammed L Alenezi, Shahd Saud S Alenezi, Afaf. Alruwaili","doi":"10.36348/sjmps.2023.v09i12.008","DOIUrl":"https://doi.org/10.36348/sjmps.2023.v09i12.008","url":null,"abstract":"Background: One of the most serious acute metabolic complications of type 1 diabetes (T1D) is diabetic ketoacidosis (DKA), which is characterised by acidosis, ketosis, and frequently hyperglycemia. Objectives: To summarize the recent epidemiological data and risk factors for developing DKA in adult T1D patients. Methods: PubMed, SCOPUS, Web of Science, and Science Direct were systematically searched for relevant literature. Rayyan QRCI was employed throughout this comprehensive process. Results & interpretation: We included eleven studies with a total of 104388 participants, and 52733 (50.5%) were males. The incidence of DKA in patients with T1D ranged from 2% to 64.8%. Risk factors for developing DKA included non-adherence, alcohol, higher HbA1c levels, longer-term diabetes, teenage age group, female gender, associated comorbid conditions, and intake of fat and carbohydrates. It's interesting to note that despair, drug misuse, and social deprivation are prevalent among DKA patients who are admitted. Consuming fibre and using freeStyle Libre protected T1D patients from developing DKA. Future research is obviously needed to provide a more comprehensive description of the epidemiology of DKA among adult T1D patients.","PeriodicalId":21367,"journal":{"name":"Saudi Journal of Medical and Pharmaceutical Sciences","volume":"50 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139007160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-12DOI: 10.36348/sjmps.2023.v09i12.007
Fahad Saad Z Alanazi, Yosef Soltan H Alrawaili
Background: Several research endeavours have endeavoured to evaluate the impact of smoking on the physiology of male and female reproduction. Encompassing sperm parameters, male reproductive architecture, and the male hormonal axes. However, the outcomes have been conflicting and ambiguous. Objectives: To investigate the published literature on the effect of smoking on female and male reproductive health. Methods: PubMed, SCOPUS, Web of Science, and Science Direct were systematically searched for relevant literature. Rayyan QRCI was employed throughout this comprehensive process. Results & interpretation: We included thirteen studies with a total of 10092 participants; 4419 (43.8%) were males, and 5673 (56.2%) were females. Smoking is a risk factor in and of itself for male reproductive health. This is more likely to explain smokers' elevated SHBG levels and differential activity of the seminal antioxidant system. These negative effects included abnormal semen motility, volume, count, and morphology. Additionally, smoking had no discernible impact on women's fertility or ovarian reserve, according to this study. More research is needed to determine whether stopping smoking can treat male infertility caused by these substances and to better understand how cigarette smoke affects both female and male fertility.
{"title":"Impact of Smoking on Reproductive Health: A Systematic Review","authors":"Fahad Saad Z Alanazi, Yosef Soltan H Alrawaili","doi":"10.36348/sjmps.2023.v09i12.007","DOIUrl":"https://doi.org/10.36348/sjmps.2023.v09i12.007","url":null,"abstract":"Background: Several research endeavours have endeavoured to evaluate the impact of smoking on the physiology of male and female reproduction. Encompassing sperm parameters, male reproductive architecture, and the male hormonal axes. However, the outcomes have been conflicting and ambiguous. Objectives: To investigate the published literature on the effect of smoking on female and male reproductive health. Methods: PubMed, SCOPUS, Web of Science, and Science Direct were systematically searched for relevant literature. Rayyan QRCI was employed throughout this comprehensive process. Results & interpretation: We included thirteen studies with a total of 10092 participants; 4419 (43.8%) were males, and 5673 (56.2%) were females. Smoking is a risk factor in and of itself for male reproductive health. This is more likely to explain smokers' elevated SHBG levels and differential activity of the seminal antioxidant system. These negative effects included abnormal semen motility, volume, count, and morphology. Additionally, smoking had no discernible impact on women's fertility or ovarian reserve, according to this study. More research is needed to determine whether stopping smoking can treat male infertility caused by these substances and to better understand how cigarette smoke affects both female and male fertility.","PeriodicalId":21367,"journal":{"name":"Saudi Journal of Medical and Pharmaceutical Sciences","volume":"8 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139008712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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