Pub Date : 2024-02-16DOI: 10.36348/sjmps.2024.v10i02.009
Celia Thomas, Abdul Malik
Ovarian cancer, the fifth most common neoplasia in women, presents challenges in diagnosis and treatment, often resulting in poor prognosis due to advanced stage at diagnosis and limited treatment options. Platinum-based chemotherapy and surgery have been the mainstay treatments, but efforts to improve outcomes with additional cytotoxic drugs have yielded mixed results. Angiogenesis plays a crucial role in tumor growth and metastasis, leading to the investigation of bevacizumab, a monoclonal antibody targeting vascular endothelial growth factor (VEGF). Clinical trials have demonstrated its efficacy in delaying disease progression in ovarian cancer. This case report illustrates the successful use of neoadjuvant chemotherapy followed by surgery and maintenance therapy with bevacizumab and olaparib in a patient with advanced ovarian cancer, highlighting the potential benefits of this treatment approach in improving survival outcomes.
{"title":"Bevacizumab with Paclitaxel and Carboplatin as Neo Adjuvant Chemotherapy for Stage 4 Ovarian Cancer- Case Report","authors":"Celia Thomas, Abdul Malik","doi":"10.36348/sjmps.2024.v10i02.009","DOIUrl":"https://doi.org/10.36348/sjmps.2024.v10i02.009","url":null,"abstract":"Ovarian cancer, the fifth most common neoplasia in women, presents challenges in diagnosis and treatment, often resulting in poor prognosis due to advanced stage at diagnosis and limited treatment options. Platinum-based chemotherapy and surgery have been the mainstay treatments, but efforts to improve outcomes with additional cytotoxic drugs have yielded mixed results. Angiogenesis plays a crucial role in tumor growth and metastasis, leading to the investigation of bevacizumab, a monoclonal antibody targeting vascular endothelial growth factor (VEGF). Clinical trials have demonstrated its efficacy in delaying disease progression in ovarian cancer. This case report illustrates the successful use of neoadjuvant chemotherapy followed by surgery and maintenance therapy with bevacizumab and olaparib in a patient with advanced ovarian cancer, highlighting the potential benefits of this treatment approach in improving survival outcomes.","PeriodicalId":21367,"journal":{"name":"Saudi Journal of Medical and Pharmaceutical Sciences","volume":"84 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140454686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-12DOI: 10.36348/sjmps.2024.v10i02.008
Sarah Emad Alsayed
Background: The ability of the first responder to identify and effectively treat hypovolemic shock will determine whether or not a child with severe volume depletion survives in the emergency room. Although the fundamentals of fluid and electrolyte therapy have been studied for decades, the issue is still difficult to resolve because there is no universally accepted therapeutic care approach. Objectives: This systematic review aims to study the updated management of dehydration and electrolyte disturbance in children and infants. Methods: PubMed, Science Direct, and Google Scholar were systematically searched for relevant literature. Rayyan QRCI was employed throughout this comprehensive process. Results & interpretation: This review included a total of ten studies with 2285 patients, and 883 (38.6%) were males. According to this comprehensive study, home-based therapy and ORS were successful in straightforward instances. Other methods, such as ORS plus Xyloglucan and ORS with honeybee added, were secure and efficient in reducing the frequency of vomiting and diarrhea. The electrolyte balance and rehydration of the patients were improved by diluted apple juice, rehydration treatments, and preferred fluids. However, gelatin tannate proved ineffective for rehydrating the child, although it advised against ever stopping breastfeeding. Drugs like intravenous Metoclopramide and Domperidone demonstrated efficacy for treating pediatric dehydration in the event that ORS failed.
背景：急救人员识别和有效治疗低血容量性休克的能力将决定严重血容量耗竭的患儿能否在急诊室存活下来。尽管对液体和电解质疗法的基本原理已经研究了数十年，但由于没有一种普遍接受的治疗护理方法，因此这一问题仍然难以解决。目的：本系统综述旨在研究儿童和婴儿脱水和电解质紊乱的最新治疗方法。研究方法系统检索了 PubMed、Science Direct 和 Google Scholar 上的相关文献。在整个综合过程中使用了 Rayyan QRCI。结果与解释：本综述共包括 10 项研究，2285 名患者，其中 883 名（38.6%）为男性。根据这项综合研究，家庭治疗和口服体液补充剂在直接的情况下是成功的。其他方法，如口服补液盐加木糖醇和口服补液盐加蜜蜂，在减少呕吐和腹泻频率方面安全有效。稀释苹果汁、补液疗法和首选液体可改善患者的电解质平衡和补液情况。然而，事实证明鞣酸明胶对儿童补液无效，尽管它建议永远不要停止母乳喂养。在口服补液盐无效的情况下，静脉注射甲氧氯普胺和多潘立酮等药物可有效治疗小儿脱水。
{"title":"Updates in Oral Management of Dehydration and Electrolyte Disturbance in Infants and Children: A Systematic Review","authors":"Sarah Emad Alsayed","doi":"10.36348/sjmps.2024.v10i02.008","DOIUrl":"https://doi.org/10.36348/sjmps.2024.v10i02.008","url":null,"abstract":"Background: The ability of the first responder to identify and effectively treat hypovolemic shock will determine whether or not a child with severe volume depletion survives in the emergency room. Although the fundamentals of fluid and electrolyte therapy have been studied for decades, the issue is still difficult to resolve because there is no universally accepted therapeutic care approach. Objectives: This systematic review aims to study the updated management of dehydration and electrolyte disturbance in children and infants. Methods: PubMed, Science Direct, and Google Scholar were systematically searched for relevant literature. Rayyan QRCI was employed throughout this comprehensive process. Results & interpretation: This review included a total of ten studies with 2285 patients, and 883 (38.6%) were males. According to this comprehensive study, home-based therapy and ORS were successful in straightforward instances. Other methods, such as ORS plus Xyloglucan and ORS with honeybee added, were secure and efficient in reducing the frequency of vomiting and diarrhea. The electrolyte balance and rehydration of the patients were improved by diluted apple juice, rehydration treatments, and preferred fluids. However, gelatin tannate proved ineffective for rehydrating the child, although it advised against ever stopping breastfeeding. Drugs like intravenous Metoclopramide and Domperidone demonstrated efficacy for treating pediatric dehydration in the event that ORS failed.","PeriodicalId":21367,"journal":{"name":"Saudi Journal of Medical and Pharmaceutical Sciences","volume":"175 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139843244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-12DOI: 10.36348/sjmps.2024.v10i02.008
Sarah Emad Alsayed
Background: The ability of the first responder to identify and effectively treat hypovolemic shock will determine whether or not a child with severe volume depletion survives in the emergency room. Although the fundamentals of fluid and electrolyte therapy have been studied for decades, the issue is still difficult to resolve because there is no universally accepted therapeutic care approach. Objectives: This systematic review aims to study the updated management of dehydration and electrolyte disturbance in children and infants. Methods: PubMed, Science Direct, and Google Scholar were systematically searched for relevant literature. Rayyan QRCI was employed throughout this comprehensive process. Results & interpretation: This review included a total of ten studies with 2285 patients, and 883 (38.6%) were males. According to this comprehensive study, home-based therapy and ORS were successful in straightforward instances. Other methods, such as ORS plus Xyloglucan and ORS with honeybee added, were secure and efficient in reducing the frequency of vomiting and diarrhea. The electrolyte balance and rehydration of the patients were improved by diluted apple juice, rehydration treatments, and preferred fluids. However, gelatin tannate proved ineffective for rehydrating the child, although it advised against ever stopping breastfeeding. Drugs like intravenous Metoclopramide and Domperidone demonstrated efficacy for treating pediatric dehydration in the event that ORS failed.
背景：急救人员识别和有效治疗低血容量性休克的能力将决定严重血容量耗竭的患儿能否在急诊室存活下来。尽管对液体和电解质疗法的基本原理已经研究了数十年，但由于没有一种普遍接受的治疗护理方法，因此这一问题仍然难以解决。目的：本系统综述旨在研究儿童和婴儿脱水和电解质紊乱的最新治疗方法。研究方法系统检索了 PubMed、Science Direct 和 Google Scholar 上的相关文献。在整个综合过程中使用了 Rayyan QRCI。结果与解释：本综述共包括 10 项研究，2285 名患者，其中 883 名（38.6%）为男性。根据这项综合研究，家庭治疗和口服体液补充剂在直接的情况下是成功的。其他方法，如口服补液盐加木糖醇和口服补液盐加蜜蜂，在减少呕吐和腹泻频率方面安全有效。稀释苹果汁、补液疗法和首选液体可改善患者的电解质平衡和补液情况。然而，事实证明鞣酸明胶对儿童补液无效，尽管它建议永远不要停止母乳喂养。在口服补液盐无效的情况下，静脉注射甲氧氯普胺和多潘立酮等药物可有效治疗小儿脱水。
{"title":"Updates in Oral Management of Dehydration and Electrolyte Disturbance in Infants and Children: A Systematic Review","authors":"Sarah Emad Alsayed","doi":"10.36348/sjmps.2024.v10i02.008","DOIUrl":"https://doi.org/10.36348/sjmps.2024.v10i02.008","url":null,"abstract":"Background: The ability of the first responder to identify and effectively treat hypovolemic shock will determine whether or not a child with severe volume depletion survives in the emergency room. Although the fundamentals of fluid and electrolyte therapy have been studied for decades, the issue is still difficult to resolve because there is no universally accepted therapeutic care approach. Objectives: This systematic review aims to study the updated management of dehydration and electrolyte disturbance in children and infants. Methods: PubMed, Science Direct, and Google Scholar were systematically searched for relevant literature. Rayyan QRCI was employed throughout this comprehensive process. Results & interpretation: This review included a total of ten studies with 2285 patients, and 883 (38.6%) were males. According to this comprehensive study, home-based therapy and ORS were successful in straightforward instances. Other methods, such as ORS plus Xyloglucan and ORS with honeybee added, were secure and efficient in reducing the frequency of vomiting and diarrhea. The electrolyte balance and rehydration of the patients were improved by diluted apple juice, rehydration treatments, and preferred fluids. However, gelatin tannate proved ineffective for rehydrating the child, although it advised against ever stopping breastfeeding. Drugs like intravenous Metoclopramide and Domperidone demonstrated efficacy for treating pediatric dehydration in the event that ORS failed.","PeriodicalId":21367,"journal":{"name":"Saudi Journal of Medical and Pharmaceutical Sciences","volume":"18 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139783502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-06DOI: 10.36348/sjmps.2024.v10i02.007
K. M, Sylla, F, Beydari, B. H, K. I, T. M, T. Y., Sacko, D, H. M, Bamba, K, S. D, Fané, B, Maïga, L, Kontao, N, Doumbia, A, Fatim, D, Maïga, M, Coulibaly, C, S. K, Sylla, M
Hepatic abscess is a suppurative collection developed in a neoformed hepatic cavity as a result of the invasion and multiplication of micro-organisms. The prognosis depends on early diagnosis and rapid treatment. The aim of the study was to determine the clinical, biological, ultrasound and therapeutic characteristics of liver abscesses in children aged between 1 month and 15 years hospitalised in the Paediatrics Ward of the District Hospital in Commune V, Bamako. This was a retrospective descriptive study which took place from January 2017 to December 2020, i.e. a period of 4 years, and a prospective study from January 2019 to December 2020, including all children aged between 1 and 15 years in whom the diagnosis of liver abscess had been confirmed by liver ultrasound. Out of 2756 children hospitalised during the study period from January 2017 to December 2020, i.e. a période of 4 years, 12 patients were diagnosed with liver abscess, i.e. a frequency of 0.43% or 4 cases/1000 admissions, with a female predominance of 58.3%, i.e. a sex ratio of 0.7. The mean age was 57 ± 34 months, with extremes of 16 and 120 months. The main reason for consultation was abdominal pain associated with fever, accounting for 75% of patients. Pus culture was positive for Staphylococcus Aureus in one patient (8%). Amebic serology was positive in 33% of patients. Ultrasound revealed a predominance of single abscesses located in the right lobe of the liver in 42% of patients. However, 92% of patients were cured, with an average hospital stay of 12 days, ranging from 2 to 19 days. Liver abscesses uncommon in our context, an early diagnosis and management can improve the prognosis.
{"title":"Child Liver Abcess: Study of 12 Cases in the Pediatric Ward of the District Hospital of Bamako","authors":"K. M, Sylla, F, Beydari, B. H, K. I, T. M, T. Y., Sacko, D, H. M, Bamba, K, S. D, Fané, B, Maïga, L, Kontao, N, Doumbia, A, Fatim, D, Maïga, M, Coulibaly, C, S. K, Sylla, M","doi":"10.36348/sjmps.2024.v10i02.007","DOIUrl":"https://doi.org/10.36348/sjmps.2024.v10i02.007","url":null,"abstract":"Hepatic abscess is a suppurative collection developed in a neoformed hepatic cavity as a result of the invasion and multiplication of micro-organisms. The prognosis depends on early diagnosis and rapid treatment. The aim of the study was to determine the clinical, biological, ultrasound and therapeutic characteristics of liver abscesses in children aged between 1 month and 15 years hospitalised in the Paediatrics Ward of the District Hospital in Commune V, Bamako. This was a retrospective descriptive study which took place from January 2017 to December 2020, i.e. a period of 4 years, and a prospective study from January 2019 to December 2020, including all children aged between 1 and 15 years in whom the diagnosis of liver abscess had been confirmed by liver ultrasound. Out of 2756 children hospitalised during the study period from January 2017 to December 2020, i.e. a période of 4 years, 12 patients were diagnosed with liver abscess, i.e. a frequency of 0.43% or 4 cases/1000 admissions, with a female predominance of 58.3%, i.e. a sex ratio of 0.7. The mean age was 57 ± 34 months, with extremes of 16 and 120 months. The main reason for consultation was abdominal pain associated with fever, accounting for 75% of patients. Pus culture was positive for Staphylococcus Aureus in one patient (8%). Amebic serology was positive in 33% of patients. Ultrasound revealed a predominance of single abscesses located in the right lobe of the liver in 42% of patients. However, 92% of patients were cured, with an average hospital stay of 12 days, ranging from 2 to 19 days. Liver abscesses uncommon in our context, an early diagnosis and management can improve the prognosis.","PeriodicalId":21367,"journal":{"name":"Saudi Journal of Medical and Pharmaceutical Sciences","volume":"254 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139858350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-06DOI: 10.36348/sjmps.2024.v10i02.007
K. M, Sylla, F, Beydari, B. H, K. I, T. M, T. Y., Sacko, D, H. M, Bamba, K, S. D, Fané, B, Maïga, L, Kontao, N, Doumbia, A, Fatim, D, Maïga, M, Coulibaly, C, S. K, Sylla, M
Hepatic abscess is a suppurative collection developed in a neoformed hepatic cavity as a result of the invasion and multiplication of micro-organisms. The prognosis depends on early diagnosis and rapid treatment. The aim of the study was to determine the clinical, biological, ultrasound and therapeutic characteristics of liver abscesses in children aged between 1 month and 15 years hospitalised in the Paediatrics Ward of the District Hospital in Commune V, Bamako. This was a retrospective descriptive study which took place from January 2017 to December 2020, i.e. a period of 4 years, and a prospective study from January 2019 to December 2020, including all children aged between 1 and 15 years in whom the diagnosis of liver abscess had been confirmed by liver ultrasound. Out of 2756 children hospitalised during the study period from January 2017 to December 2020, i.e. a période of 4 years, 12 patients were diagnosed with liver abscess, i.e. a frequency of 0.43% or 4 cases/1000 admissions, with a female predominance of 58.3%, i.e. a sex ratio of 0.7. The mean age was 57 ± 34 months, with extremes of 16 and 120 months. The main reason for consultation was abdominal pain associated with fever, accounting for 75% of patients. Pus culture was positive for Staphylococcus Aureus in one patient (8%). Amebic serology was positive in 33% of patients. Ultrasound revealed a predominance of single abscesses located in the right lobe of the liver in 42% of patients. However, 92% of patients were cured, with an average hospital stay of 12 days, ranging from 2 to 19 days. Liver abscesses uncommon in our context, an early diagnosis and management can improve the prognosis.
{"title":"Child Liver Abcess: Study of 12 Cases in the Pediatric Ward of the District Hospital of Bamako","authors":"K. M, Sylla, F, Beydari, B. H, K. I, T. M, T. Y., Sacko, D, H. M, Bamba, K, S. D, Fané, B, Maïga, L, Kontao, N, Doumbia, A, Fatim, D, Maïga, M, Coulibaly, C, S. K, Sylla, M","doi":"10.36348/sjmps.2024.v10i02.007","DOIUrl":"https://doi.org/10.36348/sjmps.2024.v10i02.007","url":null,"abstract":"Hepatic abscess is a suppurative collection developed in a neoformed hepatic cavity as a result of the invasion and multiplication of micro-organisms. The prognosis depends on early diagnosis and rapid treatment. The aim of the study was to determine the clinical, biological, ultrasound and therapeutic characteristics of liver abscesses in children aged between 1 month and 15 years hospitalised in the Paediatrics Ward of the District Hospital in Commune V, Bamako. This was a retrospective descriptive study which took place from January 2017 to December 2020, i.e. a period of 4 years, and a prospective study from January 2019 to December 2020, including all children aged between 1 and 15 years in whom the diagnosis of liver abscess had been confirmed by liver ultrasound. Out of 2756 children hospitalised during the study period from January 2017 to December 2020, i.e. a période of 4 years, 12 patients were diagnosed with liver abscess, i.e. a frequency of 0.43% or 4 cases/1000 admissions, with a female predominance of 58.3%, i.e. a sex ratio of 0.7. The mean age was 57 ± 34 months, with extremes of 16 and 120 months. The main reason for consultation was abdominal pain associated with fever, accounting for 75% of patients. Pus culture was positive for Staphylococcus Aureus in one patient (8%). Amebic serology was positive in 33% of patients. Ultrasound revealed a predominance of single abscesses located in the right lobe of the liver in 42% of patients. However, 92% of patients were cured, with an average hospital stay of 12 days, ranging from 2 to 19 days. Liver abscesses uncommon in our context, an early diagnosis and management can improve the prognosis.","PeriodicalId":21367,"journal":{"name":"Saudi Journal of Medical and Pharmaceutical Sciences","volume":"6 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139798690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01DOI: 10.36348/sjmps.2024.v10i02.004
Kazi Sohel Iqbal, Riditta Mustika, Sourov Hossain, Ruksana Parveen, Md. Alfazzaman Md. Alfazzaman, Md. Jamaluddin Md. Jamaluddin, Tanvir Ahmed Shohan, A. M. K. Hasan
Introduction: Open appendectomy (OA) and laparoscopic appendectomy (LA) are the choices of treatment for acute appendicitis. However, laparoscopic approach is emerging for the benefits it provides, but it also sometimes may has some drawbacks like OA including fistula. Objective: This retrospective study aims to investigate the management of fistula in 50 post appendicectomy fistula patients. Methods: A retrospective study was done at MH Samorita Medical College & Hospital, Hi-Tech Surgicare Hospital & Piles Centre, Savar Specialized Hospital and Lab Zone Hospital Savar, Bangladesh during January 2019 to December 2023 from January 2019 to December 2023, among the patients who had underwent laparoscopic appendicectomy and open appendicectomy. The total study population was 50, among which 33 (66%) patients were in open appendectomy and 17 (34%) were in laparoscopic appendectomy. The patients’ age group included 10 years to 50 years of both male and female patients. P< 0.005 was considered significant in this study. Results: Out of total study population, 33 were from OA (66%) and 17 were from LA (34%) group. Most of the study patients were male, aged 21-30 years age group. Fistulogram found to be the commonly use method to diagnose fistula. Tuberculosis was found to be the frequent cause of post appendicectomy fistula. Conclusion: Post appendicectomy seems to have different outcomes with some adverse impact, fistula is one of them. The present study finds that the chances of post appendicectomy fistula is less in LA group compared to OA. Proper study and better investigation may bring this to null with time.
导言：开腹阑尾切除术（OA）和腹腔镜阑尾切除术（LA）是治疗急性阑尾炎的首选方法。然而，腹腔镜方法因其优点而逐渐兴起，但有时也会像开腹阑尾切除术一样存在一些缺点，包括瘘管。研究目的这项回顾性研究旨在调查 50 名阑尾切除术后瘘管患者的瘘管处理情况。方法：2019年1月至2023年12月期间，在孟加拉国MH Samorita医学院和医院、Hi-Tech Surgicare医院和痔疮中心、Savar专科医院和Lab Zone医院Savar分院对接受腹腔镜阑尾切除术和开腹阑尾切除术的患者进行了回顾性研究。研究总人数为 50 人，其中 33 人（66%）接受过开腹阑尾切除术，17 人（34%）接受过腹腔镜阑尾切除术。男女患者的年龄均为 10 岁至 50 岁。本研究以 P< 0.005 为差异显著。研究结果在所有研究人群中，33 人来自 OA 组（66%），17 人来自 LA 组（34%）。大部分患者为男性，年龄在 21-30 岁之间。瘘管造影是诊断瘘管的常用方法。肺结核是阑尾切除术后瘘管的常见病因。结论阑尾切除术后似乎会产生不同的结果，并带来一些不利影响，瘘管就是其中之一。本研究发现，与 OA 相比，LA 组阑尾切除术后出现瘘管的几率较小。随着时间的推移，适当的研究和更好的调查可能会使这一结果为零。
{"title":"Post Appendicectomy Fistula: A Review of Its Management in 50 Cases","authors":"Kazi Sohel Iqbal, Riditta Mustika, Sourov Hossain, Ruksana Parveen, Md. Alfazzaman Md. Alfazzaman, Md. Jamaluddin Md. Jamaluddin, Tanvir Ahmed Shohan, A. M. K. Hasan","doi":"10.36348/sjmps.2024.v10i02.004","DOIUrl":"https://doi.org/10.36348/sjmps.2024.v10i02.004","url":null,"abstract":"Introduction: Open appendectomy (OA) and laparoscopic appendectomy (LA) are the choices of treatment for acute appendicitis. However, laparoscopic approach is emerging for the benefits it provides, but it also sometimes may has some drawbacks like OA including fistula. Objective: This retrospective study aims to investigate the management of fistula in 50 post appendicectomy fistula patients. Methods: A retrospective study was done at MH Samorita Medical College & Hospital, Hi-Tech Surgicare Hospital & Piles Centre, Savar Specialized Hospital and Lab Zone Hospital Savar, Bangladesh during January 2019 to December 2023 from January 2019 to December 2023, among the patients who had underwent laparoscopic appendicectomy and open appendicectomy. The total study population was 50, among which 33 (66%) patients were in open appendectomy and 17 (34%) were in laparoscopic appendectomy. The patients’ age group included 10 years to 50 years of both male and female patients. P< 0.005 was considered significant in this study. Results: Out of total study population, 33 were from OA (66%) and 17 were from LA (34%) group. Most of the study patients were male, aged 21-30 years age group. Fistulogram found to be the commonly use method to diagnose fistula. Tuberculosis was found to be the frequent cause of post appendicectomy fistula. Conclusion: Post appendicectomy seems to have different outcomes with some adverse impact, fistula is one of them. The present study finds that the chances of post appendicectomy fistula is less in LA group compared to OA. Proper study and better investigation may bring this to null with time.","PeriodicalId":21367,"journal":{"name":"Saudi Journal of Medical and Pharmaceutical Sciences","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139889616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01DOI: 10.36348/sjmps.2024.v10i02.001
S. A, Coulibaly, O. S, Beydari, B. H, K. A, D. M, T. B, T. H, Kané, M, K. M, Diallo, O, Dama, M, C. O, Touré, A, Mounkoro, M, Kanikomo, D
Introduction: Pilocytic astrocytoma is the most common cerebral glioma in pediatric age, preferentially located in the posterior cerebral fossa. Atypical presentations have rarely been described in the literature. Clinical Case: We report a case of pilocytic astrocytoma whose appearance on CT scan is unusual. It concerns a young boy of 9 years old, who presented convulsive seizures since the age of 6 years old, followed by general practitioners with irregular treatment based on gardenal. 2 months ago the seizures became more frequent and this prompted a specialist consultation with the neurologist, after a brain scan he referred the patient to us. The neurological examination was unremarkable today. Brain CT with contrast showed a right parietal lesion. It was a lesion with a double cystic and fleshy component associated with calcifications with heterogeneous enhancement which amputated the posterior horn of the lateral ventricle. The radiological appearance was in favor of a low-grade oligodendroglioma. The patient underwent surgery with complete macroscopic excision of the lesion. Histological examination revealed a pilocytic astrocytoma (grade I). Conclusion: The usual radiological appearance of pilocytic astrocytoma combines a cystic part and a highly contrasting mural nodule. It rarely presents in the form of a supratentorial lesion with calcifications. This form of presentation is rare and can lead to confusion with other gliomas. We can achieve healing for the patient with total excision.
{"title":"Atypical Presentation of a Pilocytic Astrocytoma at the Regional Hospital of Ségou in Mali country","authors":"S. A, Coulibaly, O. S, Beydari, B. H, K. A, D. M, T. B, T. H, Kané, M, K. M, Diallo, O, Dama, M, C. O, Touré, A, Mounkoro, M, Kanikomo, D","doi":"10.36348/sjmps.2024.v10i02.001","DOIUrl":"https://doi.org/10.36348/sjmps.2024.v10i02.001","url":null,"abstract":"Introduction: Pilocytic astrocytoma is the most common cerebral glioma in pediatric age, preferentially located in the posterior cerebral fossa. Atypical presentations have rarely been described in the literature. Clinical Case: We report a case of pilocytic astrocytoma whose appearance on CT scan is unusual. It concerns a young boy of 9 years old, who presented convulsive seizures since the age of 6 years old, followed by general practitioners with irregular treatment based on gardenal. 2 months ago the seizures became more frequent and this prompted a specialist consultation with the neurologist, after a brain scan he referred the patient to us. The neurological examination was unremarkable today. Brain CT with contrast showed a right parietal lesion. It was a lesion with a double cystic and fleshy component associated with calcifications with heterogeneous enhancement which amputated the posterior horn of the lateral ventricle. The radiological appearance was in favor of a low-grade oligodendroglioma. The patient underwent surgery with complete macroscopic excision of the lesion. Histological examination revealed a pilocytic astrocytoma (grade I). Conclusion: The usual radiological appearance of pilocytic astrocytoma combines a cystic part and a highly contrasting mural nodule. It rarely presents in the form of a supratentorial lesion with calcifications. This form of presentation is rare and can lead to confusion with other gliomas. We can achieve healing for the patient with total excision.","PeriodicalId":21367,"journal":{"name":"Saudi Journal of Medical and Pharmaceutical Sciences","volume":"175 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139825282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01DOI: 10.36348/sjmps.2024.v10i02.004
Kazi Sohel Iqbal, Riditta Mustika, Sourov Hossain, Ruksana Parveen, Md. Alfazzaman Md. Alfazzaman, Md. Jamaluddin Md. Jamaluddin, Tanvir Ahmed Shohan, A. M. K. Hasan
Introduction: Open appendectomy (OA) and laparoscopic appendectomy (LA) are the choices of treatment for acute appendicitis. However, laparoscopic approach is emerging for the benefits it provides, but it also sometimes may has some drawbacks like OA including fistula. Objective: This retrospective study aims to investigate the management of fistula in 50 post appendicectomy fistula patients. Methods: A retrospective study was done at MH Samorita Medical College & Hospital, Hi-Tech Surgicare Hospital & Piles Centre, Savar Specialized Hospital and Lab Zone Hospital Savar, Bangladesh during January 2019 to December 2023 from January 2019 to December 2023, among the patients who had underwent laparoscopic appendicectomy and open appendicectomy. The total study population was 50, among which 33 (66%) patients were in open appendectomy and 17 (34%) were in laparoscopic appendectomy. The patients’ age group included 10 years to 50 years of both male and female patients. P< 0.005 was considered significant in this study. Results: Out of total study population, 33 were from OA (66%) and 17 were from LA (34%) group. Most of the study patients were male, aged 21-30 years age group. Fistulogram found to be the commonly use method to diagnose fistula. Tuberculosis was found to be the frequent cause of post appendicectomy fistula. Conclusion: Post appendicectomy seems to have different outcomes with some adverse impact, fistula is one of them. The present study finds that the chances of post appendicectomy fistula is less in LA group compared to OA. Proper study and better investigation may bring this to null with time.
导言：开腹阑尾切除术（OA）和腹腔镜阑尾切除术（LA）是治疗急性阑尾炎的首选方法。然而，腹腔镜方法因其优点而逐渐兴起，但有时也会像开腹阑尾切除术一样存在一些缺点，包括瘘管。研究目的这项回顾性研究旨在调查 50 名阑尾切除术后瘘管患者的瘘管处理情况。方法：2019年1月至2023年12月期间，在孟加拉国MH Samorita医学院和医院、Hi-Tech Surgicare医院和痔疮中心、Savar专科医院和Lab Zone医院Savar分院对接受腹腔镜阑尾切除术和开腹阑尾切除术的患者进行了回顾性研究。研究总人数为 50 人，其中 33 人（66%）接受过开腹阑尾切除术，17 人（34%）接受过腹腔镜阑尾切除术。男女患者的年龄均为 10 岁至 50 岁。本研究以 P< 0.005 为差异显著。研究结果在所有研究人群中，33 人来自 OA 组（66%），17 人来自 LA 组（34%）。大部分患者为男性，年龄在 21-30 岁之间。瘘管造影是诊断瘘管的常用方法。肺结核是阑尾切除术后瘘管的常见病因。结论阑尾切除术后似乎会产生不同的结果，并带来一些不利影响，瘘管就是其中之一。本研究发现，与 OA 相比，LA 组阑尾切除术后出现瘘管的几率较小。随着时间的推移，适当的研究和更好的调查可能会使这一结果为零。
{"title":"Post Appendicectomy Fistula: A Review of Its Management in 50 Cases","authors":"Kazi Sohel Iqbal, Riditta Mustika, Sourov Hossain, Ruksana Parveen, Md. Alfazzaman Md. Alfazzaman, Md. Jamaluddin Md. Jamaluddin, Tanvir Ahmed Shohan, A. M. K. Hasan","doi":"10.36348/sjmps.2024.v10i02.004","DOIUrl":"https://doi.org/10.36348/sjmps.2024.v10i02.004","url":null,"abstract":"Introduction: Open appendectomy (OA) and laparoscopic appendectomy (LA) are the choices of treatment for acute appendicitis. However, laparoscopic approach is emerging for the benefits it provides, but it also sometimes may has some drawbacks like OA including fistula. Objective: This retrospective study aims to investigate the management of fistula in 50 post appendicectomy fistula patients. Methods: A retrospective study was done at MH Samorita Medical College & Hospital, Hi-Tech Surgicare Hospital & Piles Centre, Savar Specialized Hospital and Lab Zone Hospital Savar, Bangladesh during January 2019 to December 2023 from January 2019 to December 2023, among the patients who had underwent laparoscopic appendicectomy and open appendicectomy. The total study population was 50, among which 33 (66%) patients were in open appendectomy and 17 (34%) were in laparoscopic appendectomy. The patients’ age group included 10 years to 50 years of both male and female patients. P< 0.005 was considered significant in this study. Results: Out of total study population, 33 were from OA (66%) and 17 were from LA (34%) group. Most of the study patients were male, aged 21-30 years age group. Fistulogram found to be the commonly use method to diagnose fistula. Tuberculosis was found to be the frequent cause of post appendicectomy fistula. Conclusion: Post appendicectomy seems to have different outcomes with some adverse impact, fistula is one of them. The present study finds that the chances of post appendicectomy fistula is less in LA group compared to OA. Proper study and better investigation may bring this to null with time.","PeriodicalId":21367,"journal":{"name":"Saudi Journal of Medical and Pharmaceutical Sciences","volume":"58 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139829604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01DOI: 10.36348/sjmps.2024.v10i02.003
Hamza El Jadi, Zakaria Toufga, Imane Moustaghit
Pituitary apoplexy (PA) is a rare clinical situation caused by pituitary infarction with or without haemorrhage. Although it is usually spontaneous, dopaminergic agonists (DA) are known to be predisposing factors, particularly Bromocriptine, more rarely Cabergoline. We report the case of a 31-years-old patient with a microprolactinoma who developed acute visual acuity loss due to pituitary apoplexy 5 months after taking Cabergoline. The evolution was marked by a considerable improvement of the visual state. Pituitary apoplexy is a rare situation. Often reported with Bromocriptine, PA can also occur with Cabergoline. Due to the high mortality and morbidity of apoplexy, it should be borne in mind that close monitoring is necessary when treatment with DA is prescribed and the patient should be informed of this risk. Although DA precipitate risk, treatment can be continued for hormonal and anti-tumour remission.
垂体性脑瘫（PA）是一种罕见的临床症状，由伴有或不伴有出血的垂体梗死引起。虽然它通常是自发性的，但多巴胺能激动剂（DA）是已知的易感因素，尤其是溴隐亭，卡麦角林更为罕见。我们报告了一例 31 岁的微泌乳素瘤患者的病例，该患者在服用卡贝戈林 5 个月后因垂体性视力减退而出现急性视力下降。其后，患者的视力状况明显好转。垂体性视力减退是一种罕见的情况。常有报告称使用溴隐亭时会出现垂体功能障碍，但使用卡麦角林时也会出现垂体功能障碍。由于垂体性脑瘫的死亡率和发病率都很高，因此在使用 DA 进行治疗时，有必要进行密切监测，并告知患者这种风险。虽然 DA 会诱发风险，但可以继续治疗以获得激素和抗肿瘤缓解。
{"title":"Apoplexy of Microprolactinoma after Cabergoline Therapy: Rare Situation but Big Emergency","authors":"Hamza El Jadi, Zakaria Toufga, Imane Moustaghit","doi":"10.36348/sjmps.2024.v10i02.003","DOIUrl":"https://doi.org/10.36348/sjmps.2024.v10i02.003","url":null,"abstract":"Pituitary apoplexy (PA) is a rare clinical situation caused by pituitary infarction with or without haemorrhage. Although it is usually spontaneous, dopaminergic agonists (DA) are known to be predisposing factors, particularly Bromocriptine, more rarely Cabergoline. We report the case of a 31-years-old patient with a microprolactinoma who developed acute visual acuity loss due to pituitary apoplexy 5 months after taking Cabergoline. The evolution was marked by a considerable improvement of the visual state. Pituitary apoplexy is a rare situation. Often reported with Bromocriptine, PA can also occur with Cabergoline. Due to the high mortality and morbidity of apoplexy, it should be borne in mind that close monitoring is necessary when treatment with DA is prescribed and the patient should be informed of this risk. Although DA precipitate risk, treatment can be continued for hormonal and anti-tumour remission.","PeriodicalId":21367,"journal":{"name":"Saudi Journal of Medical and Pharmaceutical Sciences","volume":"354 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139830873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01DOI: 10.36348/sjmps.2024.v10i02.001
S. A, Coulibaly, O. S, Beydari, B. H, K. A, D. M, T. B, T. H, Kané, M, K. M, Diallo, O, Dama, M, C. O, Touré, A, Mounkoro, M, Kanikomo, D
Introduction: Pilocytic astrocytoma is the most common cerebral glioma in pediatric age, preferentially located in the posterior cerebral fossa. Atypical presentations have rarely been described in the literature. Clinical Case: We report a case of pilocytic astrocytoma whose appearance on CT scan is unusual. It concerns a young boy of 9 years old, who presented convulsive seizures since the age of 6 years old, followed by general practitioners with irregular treatment based on gardenal. 2 months ago the seizures became more frequent and this prompted a specialist consultation with the neurologist, after a brain scan he referred the patient to us. The neurological examination was unremarkable today. Brain CT with contrast showed a right parietal lesion. It was a lesion with a double cystic and fleshy component associated with calcifications with heterogeneous enhancement which amputated the posterior horn of the lateral ventricle. The radiological appearance was in favor of a low-grade oligodendroglioma. The patient underwent surgery with complete macroscopic excision of the lesion. Histological examination revealed a pilocytic astrocytoma (grade I). Conclusion: The usual radiological appearance of pilocytic astrocytoma combines a cystic part and a highly contrasting mural nodule. It rarely presents in the form of a supratentorial lesion with calcifications. This form of presentation is rare and can lead to confusion with other gliomas. We can achieve healing for the patient with total excision.
{"title":"Atypical Presentation of a Pilocytic Astrocytoma at the Regional Hospital of Ségou in Mali country","authors":"S. A, Coulibaly, O. S, Beydari, B. H, K. A, D. M, T. B, T. H, Kané, M, K. M, Diallo, O, Dama, M, C. O, Touré, A, Mounkoro, M, Kanikomo, D","doi":"10.36348/sjmps.2024.v10i02.001","DOIUrl":"https://doi.org/10.36348/sjmps.2024.v10i02.001","url":null,"abstract":"Introduction: Pilocytic astrocytoma is the most common cerebral glioma in pediatric age, preferentially located in the posterior cerebral fossa. Atypical presentations have rarely been described in the literature. Clinical Case: We report a case of pilocytic astrocytoma whose appearance on CT scan is unusual. It concerns a young boy of 9 years old, who presented convulsive seizures since the age of 6 years old, followed by general practitioners with irregular treatment based on gardenal. 2 months ago the seizures became more frequent and this prompted a specialist consultation with the neurologist, after a brain scan he referred the patient to us. The neurological examination was unremarkable today. Brain CT with contrast showed a right parietal lesion. It was a lesion with a double cystic and fleshy component associated with calcifications with heterogeneous enhancement which amputated the posterior horn of the lateral ventricle. The radiological appearance was in favor of a low-grade oligodendroglioma. The patient underwent surgery with complete macroscopic excision of the lesion. Histological examination revealed a pilocytic astrocytoma (grade I). Conclusion: The usual radiological appearance of pilocytic astrocytoma combines a cystic part and a highly contrasting mural nodule. It rarely presents in the form of a supratentorial lesion with calcifications. This form of presentation is rare and can lead to confusion with other gliomas. We can achieve healing for the patient with total excision.","PeriodicalId":21367,"journal":{"name":"Saudi Journal of Medical and Pharmaceutical Sciences","volume":"57 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139885215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：