Pub Date : 2022-07-01DOI: 10.1016/j.rpsm.2019.04.003
Jorge L. Ordóñez-Carrasco, Isabel Cuadrado Guirado, Antonio Rojas Tejada
Introduction
Psychological pain is understood as an intolerable and disturbing mental state characterized by an internal experience of negative emotions. This study was aimed at making a Spanish adaptation of the Psychache Scale by Holden and colleagues in a sample of young adults.
Material and methods
The scale evaluates psychological pain as a subjective experience. It is composed of 13 items with a Likert-type response format. Following the guidelines of the International Tests Commission for the adaptation of the test, we obtained a version conceptually and linguistically equivalent to the original scale. Through an online questionnaire, participants completed the psychological pain scale along with other scales to measure depression (BDI-II), hopelessness (Beck's scale of hopelessness) and suicide risk (Plutchik suicide risk scale). The participants were 234 people (94 men, 137 women and three people who identified as a different sex) from 18 to 35 years old.
Results
The EFA showed a one-factor solution, and the FCA revealed adequate indexes of adjustment to the unifactorial model. It also showed good reliability of the test scores. The evidence of validity of the scale in relation to the other variables showed high, positive and statistically significant correlations with depression, hopelessness, suicidal ideation and suicidal risk.
Conclusion
In summary, this Spanish adaptation of the Psychache Scale could contribute to improving the evaluation of both the patient with suicide risk and the effectiveness of psychological therapy, as well as suicidal behaviour prevention and intervention.
{"title":"Escala de dolor psicológico: adaptación de la Psychache Scale al español en jóvenes adultos","authors":"Jorge L. Ordóñez-Carrasco, Isabel Cuadrado Guirado, Antonio Rojas Tejada","doi":"10.1016/j.rpsm.2019.04.003","DOIUrl":"10.1016/j.rpsm.2019.04.003","url":null,"abstract":"<div><h3>Introduction</h3><p>Psychological pain is understood as an intolerable and disturbing mental state characterized by an internal experience of negative emotions. This study was aimed at making a Spanish adaptation of the Psychache Scale by Holden and colleagues in a sample of young adults.</p></div><div><h3>Material and methods</h3><p>The scale evaluates psychological pain as a subjective experience. It is composed of 13 items with a Likert-type response format. Following the guidelines of the International Tests Commission for the adaptation of the test, we obtained a version conceptually and linguistically equivalent to the original scale. Through an online questionnaire, participants completed the psychological pain scale along with other scales to measure depression (BDI-II), hopelessness (Beck's scale of hopelessness) and suicide risk (Plutchik suicide risk scale). The participants were 234 people (94 men, 137 women and three people who identified as a different sex) from 18 to 35 years old.</p></div><div><h3>Results</h3><p>The EFA showed a one-factor solution, and the FCA revealed adequate indexes of adjustment to the unifactorial model. It also showed good reliability of the test scores. The evidence of validity of the scale in relation to the other variables showed high, positive and statistically significant correlations with depression, hopelessness, suicidal ideation and suicidal risk.</p></div><div><h3>Conclusion</h3><p>In summary, this Spanish adaptation of the Psychache Scale could contribute to improving the evaluation of both the patient with suicide risk and the effectiveness of psychological therapy, as well as suicidal behaviour prevention and intervention.</p></div>","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":"15 3","pages":"Pages 196-204"},"PeriodicalIF":9.2,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rpsm.2019.04.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37307575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.1016/j.rpsm.2021.04.004
Miguel Martinez-Roig, Jose Alfonso Arilla-Aguilella, Maria Carmen Bono-Ariño, Raquel Rolando-Urbizu, Argia Arriola-Segura
{"title":"ECT: A decision to decrease risks during COVID-19 pandemic","authors":"Miguel Martinez-Roig, Jose Alfonso Arilla-Aguilella, Maria Carmen Bono-Ariño, Raquel Rolando-Urbizu, Argia Arriola-Segura","doi":"10.1016/j.rpsm.2021.04.004","DOIUrl":"10.1016/j.rpsm.2021.04.004","url":null,"abstract":"","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":"15 2","pages":"Pages 137-139"},"PeriodicalIF":9.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rpsm.2021.04.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9236216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.1016/j.rpsm.2021.12.004
Joaquim Radua , Lydia Fortea , Edith Pomarol-Clotet , Eduard Vieta , Miquel Àngel Fullana , Aleix Solanes
{"title":"Following a healthy/balanced diet predicts lower anxiety and depression during the COVID-19 pandemic","authors":"Joaquim Radua , Lydia Fortea , Edith Pomarol-Clotet , Eduard Vieta , Miquel Àngel Fullana , Aleix Solanes","doi":"10.1016/j.rpsm.2021.12.004","DOIUrl":"10.1016/j.rpsm.2021.12.004","url":null,"abstract":"","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":"15 2","pages":"Pages 147-149"},"PeriodicalIF":9.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8679503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10450816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.1016/j.rpsm.2021.07.005
Erika Martínez-Amorós , Pilar Serra , Adriana Bassa , Diego J. Palao , Narcís Cardoner
{"title":"Discontinuation of maintenance electroconvulsive therapy: Lessons learned from the COVID-19 pandemic","authors":"Erika Martínez-Amorós , Pilar Serra , Adriana Bassa , Diego J. Palao , Narcís Cardoner","doi":"10.1016/j.rpsm.2021.07.005","DOIUrl":"10.1016/j.rpsm.2021.07.005","url":null,"abstract":"","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":"15 2","pages":"Pages 154-155"},"PeriodicalIF":9.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rpsm.2021.07.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9236221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Recently, we reported on a new MDD-like mouse model based on a regionally selective knockdown of astroglial glutamate transporters, GLAST/GLT-1, in infralimbic cortex (IL) which evokes widespread changes in mouse brain associated with the typical alterations found in MDD patients. To further characterize this new MDD-like mouse model, here we examine some transcriptional elements of glutamatergic/GABAergic neurotransmission and neuroplasticity in forebrain regions in the GLT-1 knockdown mice. Furthermore, we assess the acute ketamine effects on these transcriptional processes.
Material and methods
We used a small interfering RNA (siRNA) pool targeting GLT-1 mRNA to disrupt the GLT-1 transcription in mouse IL. Histological assays were performed to examine postsynaptic density protein-95 (PSD95), neuritin (NRN), glutamine acid descarboxilase-65 (GAD65), and GLT-1 mRNA expression in IL and hippocampus.
Results
Knockdown of GLT-1 in mouse IL leads to decreased expression of PSD95 and NRN neuroplasticity mRNAs in IL and hippocampus, which was reversed by an acute dose of ketamine antidepressant. Likewise, a single dose of ketamine also increased the mRNA levels of GAD65 and GLT-1 in IL of GLT-1 knockdown mice, reaching the basal values of control mice.
Conclusions
The glutamatergic neuronal hyperactivity and deficits in the GABA system resulting from siRNA-induced astroglial glutamate transporter knockdown in IL can compromise the integrity/plasticity of neurocircuits affected in MDD. Suitable depressive-like animal models to address the neurobiological changes in MDD are an unmet need and the development of the GLAST/GLT-1 knockdown mouse model may represent a better option to understand the rapid-acting antidepressant effects of ketamine.
{"title":"Ketamine triggers rapid antidepressant effects by modulating synaptic plasticity in a new depressive-like mouse model based on astrocyte glutamate transporter GLT-1 knockdown in infralimbic cortex","authors":"M. Neus Fullana , Verónica Paz , Francesc Artigas , Analia Bortolozzi","doi":"10.1016/j.rpsm.2021.09.002","DOIUrl":"10.1016/j.rpsm.2021.09.002","url":null,"abstract":"<div><h3>Objective</h3><p>Recently, we reported on a new MDD-like mouse model based on a regionally selective knockdown of astroglial glutamate transporters, GLAST/GLT-1, in infralimbic cortex (IL) which evokes widespread changes in mouse brain associated with the typical alterations found in MDD patients. To further characterize this new MDD-like mouse model, here we examine some transcriptional elements of glutamatergic/GABAergic neurotransmission and neuroplasticity in forebrain regions in the GLT-1 knockdown mice. Furthermore, we assess the acute ketamine effects on these transcriptional processes.</p></div><div><h3>Material and methods</h3><p>We used a small interfering RNA (siRNA) pool targeting GLT-1 mRNA to disrupt the GLT-1 transcription in mouse IL. Histological assays were performed to examine postsynaptic density protein-95 (PSD95), neuritin (NRN), glutamine acid descarboxilase-65 (GAD65), and GLT-1 mRNA expression in IL and hippocampus.</p></div><div><h3>Results</h3><p>Knockdown of GLT-1 in mouse IL leads to decreased expression of PSD95 and NRN neuroplasticity mRNAs in IL and hippocampus, which was reversed by an acute dose of ketamine antidepressant. Likewise, a single dose of ketamine also increased the mRNA levels of GAD65 and GLT-1 in IL of GLT-1 knockdown mice, reaching the basal values of control mice.</p></div><div><h3>Conclusions</h3><p>The glutamatergic neuronal hyperactivity and deficits in the GABA system resulting from siRNA-induced astroglial glutamate transporter knockdown in IL can compromise the integrity/plasticity of neurocircuits affected in MDD. Suitable depressive-like animal models to address the neurobiological changes in MDD are an unmet need and the development of the GLAST/GLT-1 knockdown mouse model may represent a better option to understand the rapid-acting antidepressant effects of ketamine.</p></div>","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":"15 2","pages":"Pages 94-100"},"PeriodicalIF":9.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73992538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.1016/j.rpsm.2021.07.006
Òscar Alcoverro-Fortuny , Ferran Viñas Usan , Carmen Elena Sanabria , José Emilio Rojo Rodes
{"title":"Mejora de la efectividad de la terapia electroconvulsiva mediante la determinación de la profundidad anestésica. Resultados preliminares","authors":"Òscar Alcoverro-Fortuny , Ferran Viñas Usan , Carmen Elena Sanabria , José Emilio Rojo Rodes","doi":"10.1016/j.rpsm.2021.07.006","DOIUrl":"10.1016/j.rpsm.2021.07.006","url":null,"abstract":"","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":"15 2","pages":"Pages 151-153"},"PeriodicalIF":9.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39367538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.1016/j.rpsm.2022.05.001
Benedicto Crespo-Facorro
{"title":"Making the most of biomarkers in psychiatry","authors":"Benedicto Crespo-Facorro","doi":"10.1016/j.rpsm.2022.05.001","DOIUrl":"10.1016/j.rpsm.2022.05.001","url":null,"abstract":"","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":"15 2","pages":"Pages 63-64"},"PeriodicalIF":9.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72723397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.1016/j.rpsm.2021.07.001
Pau Soldevila-Matías , Georgios Schoretsanitis , Diana Tordesillas-Gutierrez , Manuel J. Cuesta , Renato de Filippis , Rosa Ayesa-Arriola , Carlos González-Vivas , Esther Setién-Suero , Norma Verdolini , Julio Sanjuán , Joaquim Radua , Benedicto Crespo-Facorro
Objective
Neurological correlates of impaired insight in non-affective psychosis remain unclear. This study aimed to review and meta-analyze the studies assessing the grey matter volumetric correlates of impaired insight in non-affective psychosis.
Methods
This study consisted of a systematic review of 23 studies, and a meta-analysis with SDM-PSI of the 11 studies that were whole-brain and reported maps or peaks of correlation of studies investigating the grey matter volumetric correlates of insight assessments of non-affective psychosis, PubMed and OVID datasets were independently reviewed for articles reporting neuroimaging correlates of insight in non-affective psychosis. Quality assessment was realized following previous methodological approaches for the ABC quality assessment test of imaging studies, based on two main criteria: the statistical power and the multidimensional assessment of insight. Study peaks of correlation between grey matter volume and insight were used to recreate brain correlation maps.
Results
A total of 418 records were identified through database searching. Of these records, twenty-three magnetic resonance imaging (MRI) studies that used different insight scales were included. The quality of the evidence was high in 11 studies, moderate in nine, and low in three. Patients with reduced insight showed decreases in the frontal, temporal (specifically in superior temporal gyrus), precuneus, cingulate, insula, and occipital lobes cortical grey matter volume. The meta-analysis indicated a positive correlation between grey matter volume and insight in the right insula (i.e., the smaller the grey matter, the lower the insight).
Conclusion
Several brain areas might be involved in impaired insight in patients with non-affective psychoses. The methodologies employed, such as the applied insight scales, may have contributed to the considerable discrepancies in the findings.
{"title":"Neuroimaging correlates of insight in non-affective psychosis: A systematic review and meta-analysis","authors":"Pau Soldevila-Matías , Georgios Schoretsanitis , Diana Tordesillas-Gutierrez , Manuel J. Cuesta , Renato de Filippis , Rosa Ayesa-Arriola , Carlos González-Vivas , Esther Setién-Suero , Norma Verdolini , Julio Sanjuán , Joaquim Radua , Benedicto Crespo-Facorro","doi":"10.1016/j.rpsm.2021.07.001","DOIUrl":"10.1016/j.rpsm.2021.07.001","url":null,"abstract":"<div><h3>Objective</h3><p>Neurological correlates of impaired insight in non-affective psychosis remain unclear. This study aimed to review and meta-analyze the studies assessing the grey matter volumetric correlates of impaired insight in non-affective psychosis.</p></div><div><h3>Methods</h3><p>This study consisted of a systematic review of 23 studies, and a meta-analysis with SDM-PSI of the 11 studies that were whole-brain and reported maps or peaks of correlation of studies investigating the grey matter volumetric correlates of insight assessments of non-affective psychosis, PubMed and OVID datasets were independently reviewed for articles reporting neuroimaging correlates of insight in non-affective psychosis. Quality assessment was realized following previous methodological approaches for the ABC quality assessment test of imaging studies, based on two main criteria: the statistical power and the multidimensional assessment of insight. Study peaks of correlation between grey matter volume and insight were used to recreate brain correlation maps.</p></div><div><h3>Results</h3><p>A total of 418 records were identified through database searching. Of these records, twenty-three magnetic resonance imaging (MRI) studies that used different insight scales were included. The quality of the evidence was high in 11 studies, moderate in nine, and low in three. Patients with reduced insight showed decreases in the frontal, temporal (specifically in superior temporal gyrus), precuneus, cingulate, insula, and occipital lobes cortical grey matter volume. The meta-analysis indicated a positive correlation between grey matter volume and insight in the right insula (i.e., the smaller the grey matter, the lower the insight).</p></div><div><h3>Conclusion</h3><p>Several brain areas might be involved in impaired insight in patients with non-affective psychoses. The methodologies employed, such as the applied insight scales, may have contributed to the considerable discrepancies in the findings.</p></div>","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":"15 2","pages":"Pages 117-133"},"PeriodicalIF":9.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39191493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.1016/j.rpsm.2020.10.001
Maite Santurtún , Ana García Blanco
{"title":"¿Son concluyentes los estudios epidemiológicos de suicidio en España?","authors":"Maite Santurtún , Ana García Blanco","doi":"10.1016/j.rpsm.2020.10.001","DOIUrl":"10.1016/j.rpsm.2020.10.001","url":null,"abstract":"","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":"15 2","pages":"Pages 150-151"},"PeriodicalIF":9.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38505660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.1016/j.rpsm.2022.01.005
Juan Antonio Becerra-García, Teresa Sánchez-Gutiérrez, Sara Barbeito Resa, Ana Calvo Calvo
{"title":"Mortalidad por COVID-19 y su relación con las búsquedas en internet sobre salud mental durante el primer año de pandemia","authors":"Juan Antonio Becerra-García, Teresa Sánchez-Gutiérrez, Sara Barbeito Resa, Ana Calvo Calvo","doi":"10.1016/j.rpsm.2022.01.005","DOIUrl":"10.1016/j.rpsm.2022.01.005","url":null,"abstract":"","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":"15 2","pages":"Pages 140-142"},"PeriodicalIF":9.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10095539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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