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Overview Of Current NGS Testing For Male Factor Infertility 当前男性因素不孕NGS检测综述
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-03-20 DOI: 10.15275/rusomj.2022.0101
M. Levkova, T. Chervenkov, M. Hachmeriyan, L. Angelova
Aim — Infertility is a global health problem. The next-generation sequencing and panel testing are offering new opportunities to further diagnose the reason for male infertility. The aim of this paper is to provide a better insight into the currently available panels for male infertility due to impaired spermatogenesis. Methods — We conducted research in the Genetic testing registry by using the keywords „infertility“, „male infertility“. We also gathered information about the number of tested genes, coverage of the panels, turnaround time, and any additional tests, which could be ordered. Results — As a result there were eleven laboratories, offering panel testing for male infertility, which tested for 230 different genes, but 65 genes (28.26%) from the different panels had an uncertain role for the tested condition. Cystic fibrosis transmembrane conductance regulator was the only gene, suggested by all laboratories. Conclusions — Next-generation sequencing could be extremely helpful in the diagnostic process of male infertility. However, clinicians should be aware that some of the included genes have an uncertain role for male infertility.
目的——不孕不育是一个全球性的健康问题。下一代测序和小组测试为进一步诊断男性不育的原因提供了新的机会。这篇论文的目的是更好地了解目前可用于男性精子发生障碍不育的面板。方法——我们在基因检测登记处使用关键词“不孕不育”、“男性不孕不育”进行了研究“。我们还收集了有关受试基因数量、小组覆盖范围、周转时间以及可以订购的任何额外测试的信息。结果——因此,有11个实验室提供男性不育的小组测试,测试了230种不同的基因,但有65种基因(28.26%)来自不同面板的数据在测试条件下具有不确定的作用。所有实验室都认为囊性纤维化跨膜电导调节剂是唯一的基因。结论——下一代测序在男性不育的诊断过程中可能非常有帮助。然而,临床医生应该意识到,一些包含的基因在男性不育中起着不确定的作用。
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引用次数: 0
Using Transcranial Magnetic Therapy In Combination With Electrostimulation For Correcting Neuroendocrine-Immune Disorders In Obese Boys 经颅磁疗联合电刺激治疗肥胖男孩神经内分泌免疫功能紊乱
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-03-20 DOI: 10.15275/rusomj.2022.0111
N. Bolotova, N. Filina, M. S. Kurdiyan, O. Kompaniets, L. Garifulina, Irina Yu. Meshcheryakova
Objective — To justify the use of low-intensity transcranial magnetic therapy (TCMT) in combination with electrostimulation (TES) for the correction of neuroendocrine-immune disorders. Material and Methods — Fifty adolescent boys with exogenous constitutional obesity 13-15 years of age were examined. The control group consisted of 30 boys aged 13-15 years without obesity and concomitant pathology. The examination included an assessment of complaints, anamnesis of the disease, life history, objective data, hormonal status, neurotransmitters and cytokines. By random sampling, the group of obese children was divided into two subgroups: subgroup 1a (n=24), who received TCMT in combination with TES, and subgroup 1b – comparison group (n=22), who received placebo therapy with disconnected electrodes. Both groups of children received identical recommendations regarding the nutrition. The effectiveness of the therapy was evaluated after 3 months. The treatment course comprised 10 procedures. Statistical processing of the obtained data was carried out using the statistical software package Statistica 8. Results — An increase in the levels of testosterone and β – endorphin as well as a decrease in estradiol and kisspeptin, which was accompanied by a decrease in body weight was observed in children of subgroup 1a (n=24) under the influence of TCMT in combination with TES. In subgroup 1b (n=22) receiving placebo therapy with disconnected electrodes, there was also a decrease in body weight, but at a much lower level. Conclusion — The use of TCMT in combination with TES led to the normalization of neuroendocrine-immune disorders and contributed to weight loss.
目的:证明低强度经颅磁疗法(TCMT)联合电刺激(TES)治疗神经内分泌免疫障碍的合理性。材料与方法——对50名13~15岁的外源性体质性肥胖男孩进行了调查。对照组由30名13-15岁的男孩组成,他们没有肥胖和伴随的病理。检查包括对主诉、疾病记忆、生活史、客观数据、激素状态、神经递质和细胞因子的评估。通过随机抽样,肥胖儿童组被分为两个亚组:1a亚组(n=24),接受TCMT联合TES治疗,1b亚组-对照组(n=22),接受安慰剂治疗,电极断开。两组儿童都收到了相同的营养建议。3个月后对治疗效果进行评估。治疗过程包括10个步骤。使用统计软件包Statistica 8对所获得的数据进行统计处理。结果——在TCMT联合TES的影响下,1a亚组(n=24)的儿童睾酮和β-内啡肽水平升高,雌二醇和kisspeptin水平下降,同时体重下降。在接受电极断开的安慰剂治疗的1b亚组(n=22)中,体重也有所下降,但水平要低得多。结论:TCMT与TES联合使用可使神经内分泌免疫紊乱正常化,并有助于减肥。
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引用次数: 1
Effect Of Mental Imagery And Physical Exercise On Musculoskeletal Pain And Quality Of Life Among Office Workers: A Commentary 心理意象和体育锻炼对上班族肌肉骨骼疼痛和生活质量的影响
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-03-20 DOI: 10.15275/rusomj.2022.0113
Bita Bagheri Gisour, M. G. Najafabadi, Hassan Gharayagh Zandi, I. Shaw
Background — Musculoskeletal pain is one of the most common problem among office workers. The main reason is related to the long time spent sitting and the associated lack of physical activity. Musculoskeletal pain can affect not only their work-related performance, but also their personal performance and quality of life. Research has mainly focused on the effects of physical activity in managing musculoskeletal pain in office workers, while research is sparse pertaining to the possible role of mental imagery on reducing musculoskeletal pain in office workers. While mental imagery has only a minor effect on pain modulation in healthy individuals, its effect appears to be more pronounced in those with chronic pain. Aim — This commentary attempts to present beneficial mental imagery techniques that can be used solely or in combination with physical exercise in an office-based setting to improve musculoskeletal pain to enhance work performance and quality of life among office workers.
背景——肌肉骨骼疼痛是上班族最常见的问题之一。主要原因与久坐和缺乏体育活动有关。肌肉骨骼疼痛不仅会影响他们的工作表现,还会影响他们的个人表现和生活质量。研究主要集中在体育活动对管理办公室工作人员肌肉骨骼疼痛的影响上,而关于心理意象在减少办公室工作人员肌骨骼疼痛方面可能发挥的作用的研究很少。虽然心理意象对健康人的疼痛调节只有很小的影响,但对慢性疼痛患者的影响似乎更为明显。目的——本评论试图展示有益的心理意象技术,这些技术可以单独使用,也可以与办公室环境中的体育锻炼结合使用,以改善肌肉骨骼疼痛,从而提高办公室工作人员的工作表现和生活质量。
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引用次数: 0
Fluid Retention In The Pulmonary Circulation As A Cause Of Pulmonary Vein Dilatation And Atrial Fibrillation Development In Chronic Heart Failure Patients 肺循环中的液体潴留是慢性心力衰竭患者肺静脉扩张和房颤发展的一个原因
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-03-20 DOI: 10.15275/rusomj.2022.0121
V. Kirillova
Objective — The study objective was to perform a transthoracic echocardiographic study of the remodeling of the left atrium and the maximum and minimum diameters of pulmonary veins, as well as remodeling regression in the process of heart failure treatment, in patients with chronic heart failure (CHF) and different forms of atrial fibrillation (AF). Material and Methods — The prospective study included patients having CHF with paroxysmal AF (n=38) and permanent AF (n=36) and without arrhythmia (n=225); the patients had their maximum and minimum diameters of the pulmonary vein measured, additionally to the standard echocardiographic protocol, before and after six months of standard therapy including a loop diuretic. Results — Structural changes in the left atrium and pulmonary veins of patients with CHF having permanent atrial fibrillation were significantly more distinct than those in patients with paroxysmal AF, in patients without arrhythmia, and in the control group. A decrease in the maximum and minimum diameters of the pulmonary vein followed by termination of AF attacks within a year of observation was detected after CHF treatment with a loop diuretic in patients with paroxysmal AF and permanent AF. Conclusion — Prescribing loop diuretics to patients with pulmonary vein dilatation detected during transthoracic echocardiography in subjects with paroxysmal AF and permanent AF results in a decrease in PV diameters and termination of AF attacks in paroxysmal AF.
目的:通过经胸超声心动图研究慢性心力衰竭(CHF)和不同形式心房颤动(AF)患者在心力衰竭治疗过程中左心房重构、肺静脉最大、最小直径及重构回归情况。材料和方法:前瞻性研究纳入了伴有阵发性房颤(n=38)和永久性房颤(n=36)且无心律失常(n=225)的CHF患者;患者在接受包括利尿剂循环在内的六个月标准治疗前后,在标准超声心动图协议的基础上,测量了肺静脉的最大和最小直径。结果:伴有永久性房颤的CHF患者左心房和肺静脉的结构改变明显比阵发性房颤患者、无心律失常患者和对照组更明显。阵发性房颤和永久性房颤患者在使用利尿剂治疗CHF后,观察一年内房颤发作终止,肺静脉最大直径和最小直径减小对阵发性房颤和永久性房颤经胸超声心动图检查发现肺静脉扩张的患者开环状利尿剂可降低阵发性房颤的PV直径并终止房颤发作。
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引用次数: 1
A Supportive-Educative Intervention For Tuberculosis Patients: Integrated Self-Care And Family-Centered Nursing 结核病患者的支持教育干预:自我照顾与以家庭为中心的综合护理
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-03-20 DOI: 10.15275/rusomj.2022.0106
Nur Melizza, R. Hargono, Makhfudli
Aim — This study aims to evaluate the effect of supportive educative system intervention on Tuberculosis (TB) patient’s family support. Material and Methods — This study was a quantitative study with a quasi-experimental design, conducted in the Public Health Center (PHC) of Kedungkandang and Ciptomulyo with 48 respondents. The respondents were divided into the control group with standard PHC intervention (n=24) and the treatment group with standard PHC intervention added with the supportive educative system (n=24). The data were analyzed by paired t-test and independent t-test. Results — There was a significant difference in family support between treatment and control. The results indicated that a supportive educative system significantly increases family support (p=0.003). Interestingly, PHC standard intervention showed improvement in family support (68.46±73.58) than supportive educative system (74.29±75.83). Supportive educative system interventions were less effective than standard PHC interventions. It could be influenced by sample characteristics, time of the study, control of variables, and other factors. Conclusion — Supportive educative interventions are effective in improving family support but are no better than standard PHC interventions.
目的:本研究旨在评估支持教育系统干预对结核病患者家庭支持的影响。▽材料和方法=本研究是在Kedungkandang和Ciptomulyo的公共卫生中心(PHC)对48名调查对象进行的准实验设计的定量研究。将被调查者分为对照组(24例)和治疗组(24例),对照组采用标准PHC干预,治疗组采用标准PHC干预加支持教育系统。采用配对t检验和独立t检验对数据进行分析。结果:治疗组和对照组在家庭支持方面有显著差异。结果显示,支持性教育系统显著增加家庭支持(p=0.003)。有趣的是,PHC标准干预在家庭支持(68.46±73.58)方面优于支持性教育系统(74.29±75.83)。支持性教育系统干预不如标准初级保健干预有效。它可能受到样本特征、研究时间、变量控制和其他因素的影响。结论:支持性教育干预在改善家庭支持方面是有效的,但并不比标准的初级保健干预更好。
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引用次数: 0
Reproducing Morphological Features Of Intervertebral Disc Using Finite Element Modeling To Predict The Course Of Cervical Spine Dorsopathy 利用有限元模型再现椎间盘形态特征预测颈椎后倾的病程
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-03-20 DOI: 10.15275/rusomj.2022.0118
E. Yakovlev, A. Ovsepyan, A. A. Smirnov, A. A. Safronova, D. Starchik, S. A. Zhivolupov, Y. Vasil'ev, S. Dydykin
Study objective — To evaluate how morphological features of intervertebral disc would affect the outcomes of finite element modeling of axial load in the cervical spine, C3-C5, in order to predict the risk of occurrence and course of dorsopathies. Material and Methods — Three-dimensional models of the cervical spine vertebrae were generated from the computed tomography data of a volunteer (24 years old male without detected pathology of his neck). Intervertebral disc models were developed in two configurations. For each model, we performed a finite element investigation of the stress-strain state with the same loading conditions. The load-displacement curves were compared with the experimental data generated from the results of previously conducted in vitro experiments. Results — The maximum and mean displacement values for the isotropic model were 1.15 mm and 0.73 ± 0.45 mm, respectively. For anisotropic model, maximum and mean displacement values were 0.86 mm and 0.47 ± 0.24 mm, correspondingly. Predicted displacement values for both models matched the experimental data fairly well. Stress profiles of intervertebral discs and stress diagrams of facet joints were calculated. Conclusion — The proposed geometric and constitutive configurations of the intervertebral disc take into account specific morphological features at low computational costs, thereby facilitating the modeling of degenerative disc changes.
研究目的-评估椎间盘形态特征如何影响颈椎(C3-C5)轴向载荷有限元建模的结果,以预测腰背病变发生的风险和病程。材料和方法:根据一名志愿者(24岁男性,未发现颈部病变)的计算机断层扫描数据生成颈椎椎体的三维模型。椎间盘模型分为两种构型。对于每个模型,我们在相同的加载条件下对应力-应变状态进行了有限元研究。将载荷-位移曲线与先前体外实验结果的实验数据进行比较。结果-各向同性模型的最大和平均位移值分别为1.15 mm和0.73±0.45 mm。各向异性模型最大位移值为0.86 mm,平均位移值为0.47±0.24 mm。两种模型的预测位移值与实验数据吻合较好。计算椎间盘应力分布图和关节突关节应力图。结论:椎间盘的几何和本构结构考虑了特定的形态特征,计算成本低,从而促进了椎间盘退行性变化的建模。
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引用次数: 3
Impact Of Obesity On Cardiac Structural And Functional Changes 肥胖对心脏结构和功能改变的影响
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-03-20 DOI: 10.15275/rusomj.2022.0103
V. Podzolkov, A. Pokrovskaya, Ulyana S. Bazhanova, D. D. Vanina, Tatiana S. Vargina
The urgency of obesity issue is undeniable. Obesity is now considered the most important risk factor of cardiovascular diseases. Numerous studies have demonstrated the negative effect of excessive adipose tissue on structural and functional changes in the heart that lead to development of left ventricular hypertrophy, arrhythmias and conduction abnormalities, as well as progression of diastolic and systolic heart failure. High prevalence of obesity – so high that it can be called a pandemic – greatly contributes to the increased incidence of cardiovascular diseases. Studying the problem of obesity is a priority area of focus for modern medicine. This article describes hormonal, metabolic and hemodynamic features of obesity impact on cardiovascular system and describes pathogenetic mechanisms of cardiovascular pathology development.
肥胖问题的紧迫性是不可否认的。肥胖现在被认为是心血管疾病最重要的危险因素。大量研究表明,过量的脂肪组织会对心脏的结构和功能变化产生负面影响,从而导致左心室肥大、心律失常和传导异常,以及舒张和收缩性心力衰竭的进展。肥胖的高患病率——高到可以称之为流行病——极大地导致了心血管疾病发病率的增加。研究肥胖问题是现代医学的一个重点领域。本文描述了肥胖对心血管系统影响的激素、代谢和血液动力学特征,并描述了心血管病理发展的发病机制。
{"title":"Impact Of Obesity On Cardiac Structural And Functional Changes","authors":"V. Podzolkov, A. Pokrovskaya, Ulyana S. Bazhanova, D. D. Vanina, Tatiana S. Vargina","doi":"10.15275/rusomj.2022.0103","DOIUrl":"https://doi.org/10.15275/rusomj.2022.0103","url":null,"abstract":"The urgency of obesity issue is undeniable. Obesity is now considered the most important risk factor of cardiovascular diseases. Numerous studies have demonstrated the negative effect of excessive adipose tissue on structural and functional changes in the heart that lead to development of left ventricular hypertrophy, arrhythmias and conduction abnormalities, as well as progression of diastolic and systolic heart failure. High prevalence of obesity – so high that it can be called a pandemic – greatly contributes to the increased incidence of cardiovascular diseases. Studying the problem of obesity is a priority area of focus for modern medicine. This article describes hormonal, metabolic and hemodynamic features of obesity impact on cardiovascular system and describes pathogenetic mechanisms of cardiovascular pathology development.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45612620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Androgen Deficiency In Men With Chronic Obstructive Pulmonary Disease 男性慢性阻塞性肺病的雄激素缺乏
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-03-20 DOI: 10.15275/rusomj.2022.0110
V. Podzolkov, Tatyana I. Ishina, I. Medvedev
Hypogonadism is a clinical condition comprising symptoms and laboratory evidence of testosterone deficiency and low androgen receptor sensitivity. The importance of hypogonadism in clinical practice is often underestimated. Androgen deficiency habitually occurs in various conditions causing abnormal functioning of many organs and systems, as well as impairing the quality of life in patients. Androgen deficiency often occurs with various somatic diseases. Chronic obstructive pulmonary disease (COPD) is one of the most important medical and social problems of modern medicine, in which severe systemic (including hormonal) disorders occur. This review presents data on androgen deficiency in men with COPD and its potential impact on the patients. We have analyzed literary sources in the eLIBRARY and PubMed databases.
性腺功能减退是一种临床疾病,包括睾酮缺乏和雄激素受体敏感性低的症状和实验室证据。性腺功能减退症在临床实践中的重要性经常被低估。雄激素缺乏通常发生在各种情况下,导致许多器官和系统功能异常,并损害患者的生活质量。雄激素缺乏症常发生在各种躯体疾病中。慢性阻塞性肺病(COPD)是现代医学中最重要的医学和社会问题之一,其中会发生严重的系统性(包括激素)疾病。这篇综述介绍了男性COPD患者雄激素缺乏的数据及其对患者的潜在影响。我们分析了eLIBRARY和PubMed数据库中的文献来源。
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引用次数: 0
Contemporary View On Thread Lifting: Histological And Anatomical Approaches 当代对提线的看法:组织学和解剖学方法
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-03-20 DOI: 10.15275/rusomj.2022.0107
O. B. Borzykh, E. I. Karpova, N. Shnayder, O. M. Demina
Currently, thread lifting in aesthetic facial rejuvenation is not the top priority, but nevertheless its popularity continues to gain momentum. In connection with increasing popularity, the number of issues related to thread lifting and its undesirable side effects also increases. In this publication, an analysis of Russian and international databases was carried out, including MedLine, PubMed, elibrary.ru, Wiley Online Library, Web of Science, over the period from 2010 to 2020 (10 years). In the search, the following keywords were used both in Russian and English: threads, thread lifting, rhytidoplasty, face rejuvenation, face lift, cog threads, Aptos, suture material. As a result, of all available publications, 51 articles were left for further analysis, on the basis of which the nuances of thread classification, histological changes in tissues in response to thread implantation, along with anatomical basics and features during the procedure of thread lifting were analyzed. The effectiveness and duration of the thread lifting effect is still subject to debate. Hence, sometimes, it is possible to identify the duration of the effect in the same study ranging from 1 month to 2 years. Despite the long history of thread lifting, there are still unresolved issues that need to be covered.
目前,美容面部年轻化中的提线并不是首要任务,但它的流行势头仍在继续。随着越来越受欢迎,与提线及其不良副作用相关的问题数量也在增加。在本出版物中,对2010年至2020年期间(10年)的俄罗斯和国际数据库进行了分析,包括MedLine、PubMed、elibrary.ru、Wiley Online Library、Web of Science。在搜索中,俄语和英语都使用了以下关键词:螺纹、提线、除皱术、面部年轻化、面部提拉、嵌齿螺纹、Aptos、缝合材料。因此,在所有可用的出版物中,有51篇文章有待进一步分析,在此基础上分析了丝线分类的细微差别、丝线植入后组织的组织学变化,以及丝线提拉过程中的解剖学基础和特征。提线效应的有效性和持续时间仍有待商榷。因此,有时可以在同一项研究中确定影响的持续时间,从1个月到2年不等。尽管提线有着悠久的历史,但仍有一些尚未解决的问题需要解决。
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引用次数: 1
The Predictive Value Of Umbilical Cord Blood Total IgE Levels In Allergic Diseases 脐血总IgE水平对变应性疾病的预测价值
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-03-20 DOI: 10.15275/rusomj.2022.0105
G. Dib, L. Doya, M. Ismaeel, Y. Ismaeel
Allergic diseases in children have increased significantly. In recent years, it affects up to 35% of children. The current study aimed to investigate the value of the umbilical cord blood total IgE levels in the prediction of the development of allergic diseases during 8 years of follow-up. Methods — In cross-sectional study included 500 infants who were born in the obstetrics department at Tishreen and Al-Assad University Hospitals during the period 2007-2015. Questionnaires were administered after the birth included gender, gestational age, birth weight, mode and season of delivery, smoking during pregnancy, and family history of allergic diseases. Umbilical cord blood total IgE levels were measured. The infants were followed up for eight years for subsequent development of allergic disorders. Results — 214 (42.8%) of 500 newborns had high umbilical cord blood total IgE levels. We followed 143 of 214 newborns for 8 years; there was an allergic family history in 51.7% of newborns. During the following period, allergic diseases developed in 76.22% of the children with high umbilical cord blood total IgE levels. Allergic symptoms in children varied between nasal allergy (19.6%), skin allergy (eczema and urticarial) (25.2%), childhood asthma (31.5%). The rate of allergic symptoms development in the presence of two factors (family history and high umbilical cord blood total IgE) was 51.7%. Conclusion — We found a high prevalence of allergic diseases in children with high umbilical cord blood total IgE. The current study could be used as a preventative strategy to reduce the risk of allergic diseases by predictive of subsequent.
儿童的过敏性疾病显著增加。近年来,它影响了高达35%的儿童。本研究旨在调查8年随访期间脐带血总IgE水平在预测过敏性疾病发展中的价值。方法——横断面研究包括2007-2015年期间在蒂什伦和阿萨德大学医院产科出生的500名婴儿。出生后进行问卷调查,包括性别、胎龄、出生体重、分娩方式和季节、怀孕期间吸烟和过敏性疾病家族史。测量脐带血总IgE水平。对这些婴儿进行了8年的随访,以了解其随后出现的过敏性疾病。结果500例新生儿中有214例(42.8%)脐血总IgE水平较高。我们对214名新生儿中的143名进行了8年的随访;51.7%的新生儿有过敏家族史。在接下来的一段时间里,76.22%的脐带血总IgE水平高的儿童出现过敏性疾病。儿童的过敏症状在鼻腔过敏(19.6%)、皮肤过敏(湿疹和荨麻疹)(25.2%)和儿童哮喘(31.5%)之间存在差异。在存在两个因素(家族史和高脐血总IgE)的情况下,过敏症状的发生率为51.7%。目前的研究可以作为一种预防策略,通过预测后续事件来降低过敏性疾病的风险。
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引用次数: 0
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Russian Open Medical Journal
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