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Integrated testing strategies for cost-sensitive time-efficient hazard classification of new chemicals: The case of skin sensitization. 新化学品成本敏感、时效性危害分类的综合测试策略:皮肤致敏的案例。
IF 3.3 3区 医学 Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS Pub Date : 2025-12-01 Epub Date: 2025-02-17 DOI: 10.1111/risa.17717
Marko Raseta, Jon Pitchford, James Cussens, John Doe

We offer an alternative approach to toxicological risk assessment of new chemicals. We combine Operations Research techniques with those from Machine Learning to tackle the decision-making process. More specifically, we use Markov decision processes and Bayesian networks to derive the optimal cost-sensitive time-efficient Integrated Testing Strategies for chemical hazard classification under minimal expected cost in a mathematically rigorous fashion. We develop Bayesian networks which outperform state-of-the-art mechanistic causal models previously reported. More specifically, these models exhibit accuracy of 90% and sensitivity and specificity of 93% and 84%, respectively. Moreover, the inferred Bayesian networks are of considerably simpler structure as they comprise only the permeation coefficient, octanol/water coefficient, and TIMES software compared to their counterparts already in print, which comprise 15 descriptors. We use these simplified causal models to study the effect of varying misclassification costs on the nature of the optimal policy by means of sensitivity analysis. We note such analysis was previously computationally infeasible due to the fact that the variables which comprised the mechanistic model were categorical assuming a large number of possible values. We find that a variety of optimal policies can emerge subject to different misclassification costs assumed. Theoretical modeling framework developed is illustrated on the concrete example of hazard classification of skin allergens of previously unknown toxicological characteristics via integrating data obtained from in silico assays alone thus contributing to the literature of toxicological decision making based on nonanimal tests.

我们为新化学品的毒理学风险评估提供了另一种方法。我们将运筹学技术与机器学习技术相结合来解决决策过程。更具体地说,我们使用马尔可夫决策过程和贝叶斯网络,以数学上严格的方式,在最小的期望成本下,推导出最优的成本敏感、时间有效的化学危害分类综合测试策略。我们开发的贝叶斯网络优于先前报道的最先进的机械因果模型。更具体地说,这些模型的准确率为90%,灵敏度和特异性分别为93%和84%。此外,与已出版的同类产品(包含15个描述符)相比,推断出的贝叶斯网络结构简单得多,因为它们仅包含渗透系数、辛醇/水系数和TIMES软件。我们利用这些简化的因果模型,通过敏感性分析研究了不同错误分类成本对最优政策性质的影响。我们注意到,由于组成机制模型的变量是分类假设大量可能值的事实,这种分析以前在计算上是不可行的。我们发现,假设不同的错误分类代价会产生各种最优策略。通过整合仅从计算机分析中获得的数据,对先前未知毒理学特征的皮肤过敏原进行危害分类的具体示例说明了所开发的理论建模框架,从而有助于基于非动物试验的毒理学决策的文献。
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引用次数: 0
Will emergency order shifting perform better than recovery waiting at costs of carbon tax and carbon emission reduction? 以碳税和碳减排为代价,紧急订单转移是否比恢复等待更好?
IF 3.3 3区 医学 Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS Pub Date : 2025-12-01 Epub Date: 2025-06-06 DOI: 10.1111/risa.70051
Baozhuang Niu, Lihua Zhu, Jian Dong, Jinbo Song

In recent years, frequent extreme disasters have challenged supply chain operations while smart risk warning systems are developed to facilitate firms' emergency order shifting to a new manufacturer. It is noted that reliable manufacturers are usually located in countries/regions levying carbon tax to achieve high ESG scores, so we consider a cross-border supply chain consisting of a global brand, a local brand, an overseas manufacturer and a local manufacturer to investigate the main tradeoffs for the global brand to emergently shift orders from the overseas manufacturer facing disruptions to a stable local manufacturer subject to carbon tax cost. The global brand has the option to wait for the recovery of overseas production but if it chooses emergent order shifting, it has to invest in carbon emission reduction due to ESG requirements. We intriguingly find that even though emergency order shifting helps avert delays caused by production disruptions, a more resilient supply chain does not necessarily lead to a higher profit for the global brand, depending on factors such as the relative market size, carbon tax cost, and the efficiency of carbon reduction investment. We also find that the global brand's emergency order shifting enables Pareto improvement of economic and environmental sustainability, but the win-win opportunities for both the global and local brand only appear under the recovery waiting strategy. So it is generally hard to coordinate the stakeholders' incentives to jointly optimize the ESG scores.

近年来,极端灾害频发给供应链运作带来了挑战,智能风险预警系统的开发促进了企业的紧急订单转移到新的制造商。值得注意的是,可靠的制造商通常位于征收碳税以获得高ESG分数的国家/地区,因此我们考虑一个由全球品牌、当地品牌、海外制造商和当地制造商组成的跨境供应链,以调查全球品牌在面临碳税成本的情况下紧急将订单从海外制造商转移到稳定的当地制造商时的主要权衡。全球品牌可以选择等待海外生产的恢复,但如果选择紧急订单转移,则必须根据ESG要求进行碳减排投资。我们有趣地发现,尽管紧急订单转移有助于避免生产中断造成的延迟,但更具弹性的供应链并不一定会给全球品牌带来更高的利润,这取决于相对市场规模、碳税成本和碳减排投资效率等因素。我们还发现,全球品牌的紧急订单转移能够实现经济和环境可持续性的帕累托改善,但全球品牌和本土品牌的双赢机会只有在复苏等待策略下才会出现。因此,协调利益相关方共同优化ESG评分的动机通常比较困难。
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引用次数: 0
Risks of ignoring uncertainty propagation in AI-augmented security pipelines. 忽视人工智能增强安全管道中不确定性传播的风险。
IF 3.3 3区 医学 Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS Pub Date : 2025-12-01 Epub Date: 2025-06-22 DOI: 10.1111/risa.70059
Emanuele Mezzi, Aurora Papotti, Fabio Massacci, Katja Tuma

The use of AI technologies is being integrated into the secure development of software-based systems, with an increasing trend of composing AI-based subsystems (with uncertain levels of performance) into automated pipelines. This presents a fundamental research challenge and seriously threatens safety-critical domains. Despite the existing knowledge about uncertainty in risk analysis, no previous work has estimated the uncertainty of AI-augmented systems given the propagation of errors in the pipeline. We provide the formal underpinnings for capturing uncertainty propagation, develop a simulator to quantify uncertainty, and evaluate the simulation of propagating errors with one case study. We discuss the generalizability of our approach and its limitations and present recommendations for evaluation policies concerning AI systems. Future work includes extending the approach by relaxing the remaining assumptions and by experimenting with a real system.

人工智能技术的使用正被集成到基于软件的系统的安全开发中,将基于人工智能的子系统(具有不确定的性能水平)组合到自动化管道中的趋势日益增加。这对基础研究提出了挑战,并严重威胁到安全关键领域。尽管已有关于风险分析中的不确定性的知识,但没有先前的工作估计人工智能增强系统在管道中传播错误的不确定性。我们提供了捕获不确定性传播的形式化基础,开发了一个模拟器来量化不确定性,并通过一个案例研究评估传播误差的模拟。我们讨论了我们的方法的概括性及其局限性,并提出了有关人工智能系统评估政策的建议。未来的工作包括通过放松剩余的假设和用实际系统进行实验来扩展该方法。
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引用次数: 0
Model averaging with logistic autoregressive conditional peak over threshold models for regional smog. 区域雾霾的logistic自回归条件峰值超过阈值模型平均。
IF 3.3 3区 医学 Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS Pub Date : 2025-12-01 Epub Date: 2025-07-07 DOI: 10.1111/risa.70069
Chunli Huang, Xu Zhao, Fengying Zhang, Haiqing Chen, Ruoqi Song, Guangwen Ma, Weihu Cheng

We propose a novel dynamic generalized Pareto distribution (GPD) framework for modeling the time-dependent behavior of the peak over threshold (POT) in extreme smog (PM2.5) time series. First, unlike static GPD, three dynamic autoregressive conditional generalized Pareto (ACP) models are introduced. Specifically, in these three dynamic models, the exceedances of air pollutant concentration are modeled by a GPD with time-dependent scale and shape parameters conditioned on past PM2.5 and other air quality factors (SO2, NO2, CO) and weather factors (daily average temperature, average relative humidity, average wind speed). Second, unlike the recent studies of ACP models, we impose a logistic function autoregressive structure on the scale and shape parameters of the ACP models, which has simple calculation and flexible modeling for the scale and shape parameters, since the logistic function is used to mean that the changes in the long memory parameter occur in a continuous manner and often applied in time series models. Third, the model averaging method is applied to improve predictive performance using AIC and BIC criteria to select combined weights of the three ACP models. In addition, based on goodness-of-fit tests, the thresholds of the three ACP models are chosen by eight automatic threshold selection procedures to avoid subjectively assigning a certain value as the threshold. Maximum likelihood estimation (MLE) is employed to estimate parameters of the ACP models and its statistical properties are investigated. Various simulation studies and an example of real data in PM2.5 time series demonstrate the superiority of the proposed ACP models and the stability of the MLE.

我们提出了一种新的动态广义帕累托分布(GPD)框架,用于模拟极端雾霾(PM2.5)时间序列中峰值超过阈值(POT)的时间依赖性行为。首先,与静态广义帕累托模型不同,本文引入了三种动态自回归条件广义帕累托模型。具体而言,在这三个动态模型中,空气污染物浓度的超标是通过GPD模型来模拟的,GPD具有随时间变化的尺度和形状参数,这些参数取决于过去PM2.5和其他空气质量因子(SO2、NO2、CO)以及天气因子(日平均温度、平均相对湿度、平均风速)。其次,与目前ACP模型的研究不同,我们在ACP模型的尺度和形状参数上施加了逻辑函数自回归结构,该结构计算简单,对尺度和形状参数建模灵活,因为逻辑函数用于表示长记忆参数的变化以连续的方式发生,通常用于时间序列模型。第三,采用模型平均法,利用AIC和BIC准则选择三个ACP模型的组合权重,提高预测性能。此外,在拟合优度检验的基础上,通过8个自动阈值选择程序来选择三个ACP模型的阈值,避免主观地指定某个值作为阈值。采用极大似然估计(MLE)对ACP模型的参数进行估计,并研究了其统计性质。各种模拟研究和PM2.5时间序列的实际数据实例证明了所提出的ACP模型的优越性和MLE的稳定性。
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引用次数: 0
Cyber Resilience and Strategic Stability: Securing Nuclear Facilities in the Digital Age. 网络弹性和战略稳定性:数字时代核设施的安全。
IF 3.3 3区 医学 Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS Pub Date : 2025-12-01 Epub Date: 2025-10-28 DOI: 10.1111/risa.70136
Syed Muhammad Saad Zaidi, Muhammad Ehsan, Sardar Jehanzaib Ghalib

In an era of increasing digitization, nuclear command systems and power plants are becoming vulnerable to cyberattacks that can disrupt operations and undermine deterrence. This article examines the evolving threat landscape, drawing on literature and documented incidents of cyber intrusions into nuclear systems to identify critical technical and policy vulnerabilities. It argues that such intrusions risk eroding second-strike credibility and may create incentives for preemptive action, thereby destabilizing strategic balances. Although regulatory bodies and international organizations have issued cybersecurity guidelines for nuclear facilities, implementation remains inconsistent. To address these challenges, the study proposes a set of resilience measures encompassing advanced technical safeguards, specialized workforce training, the establishment of international norms, and enhanced crisis communication protocols. Strengthening the cyber resilience of both civilian and military nuclear assets is presented as an urgent imperative for maintaining global security and strategic stability in the digital age.

在日益数字化的时代,核指挥系统和发电厂正变得容易受到网络攻击,这些攻击可能会破坏行动并削弱威慑。本文研究了不断变化的威胁形势,借鉴文献和记录在案的核系统网络入侵事件,以确定关键的技术和政策漏洞。它认为,这种入侵有可能侵蚀二次打击的可信度,并可能促使采取先发制人的行动,从而破坏战略平衡。尽管监管机构和国际组织已经发布了核设施网络安全指导方针,但实施情况仍不一致。为了应对这些挑战,该研究提出了一套弹性措施,包括先进的技术保障措施、专门的劳动力培训、建立国际规范和加强危机沟通协议。加强民用和军用核资产的网络弹性被认为是维护数字时代全球安全和战略稳定的迫切需要。
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引用次数: 0
Probability Distribution of Risk Priority Numbers in Failure Mode and Effects Analysis. 失效模式下风险优先级数的概率分布及影响分析。
IF 3.3 3区 医学 Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS Pub Date : 2025-12-01 Epub Date: 2025-11-09 DOI: 10.1111/risa.70143
Rahim Mahmoudvand, Alessandro Fiori Maccioni, Luca Frigau, David Banks

This study introduces a new probability model for the risk priority number (RPN) in Failure Mode and Effects Analysis (FMEA), addressing limitations of the traditional RPN calculation, which assumes independence among severity, occurrence, and detection scores. Leveraging sufficient statistics within a Bayesian framework, the proposed model captures the inherent dependencies among these components, providing a more realistic and flexible representation of risk. Simulation studies validate the estimator's superior accuracy and stability, while empirical analyses on both AI risk assessment and gas refinery fire risk data sets demonstrate its effectiveness and adaptability across diverse domains and sampling strategies. Model comparisons using p-values and the Akaike information criterion (AIC) confirm the new model as the best fit for categorical risk data, aligning naturally with our theoretical approach. The results suggest that this new model enhances the reliability and interpretability of FMEA risk assessments, providing a powerful tool for decision making and risk mitigation in complex safety-critical systems.

本文引入了失效模式与影响分析(FMEA)中风险优先级数(RPN)的一种新的概率模型,解决了传统RPN计算方法假定严重性、发生率和检测分数之间独立的局限性。利用Bayesian框架中足够的统计数据,建议的模型捕获了这些组件之间的内在依赖关系,提供了更现实和灵活的风险表示。仿真研究验证了该估计器的卓越准确性和稳定性,而对人工智能风险评估和天然气炼油厂火灾风险数据集的实证分析则证明了其在不同领域和采样策略中的有效性和适应性。使用p值和赤池信息准则(Akaike information criterion, AIC)的模型比较证实了新模型是最适合分类风险数据的,与我们的理论方法自然地一致。结果表明,该模型提高了FMEA风险评估的可靠性和可解释性,为复杂安全关键系统的决策和风险缓解提供了强有力的工具。
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引用次数: 0
Climate Mitigation Innovations From National Legislation Under Risk Conditions. 风险条件下国家立法的气候减缓创新。
IF 3.3 3区 医学 Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS Pub Date : 2025-12-01 Epub Date: 2025-11-19 DOI: 10.1111/risa.70152
Ying Liu, Chao Feng

Most nations across the globe have already embraced climate legislation to tackle the challenge of climate change. This article considers the role of country risk (i.e., economic risk, financial risk, political risk, and climate physical risk) in affecting the relationship between climate mitigation legislation (CML) on climate mitigation innovations (CMIs) using a panel of 130 countries from 1995 to 2022. The findings show that CML generally promotes CMI. However, moderating effects reveal that country risk can weaken the positive impacts of CML on CMI, underscoring the importance of integrating risk management into legislative frameworks to drive CMI. Asymmetry checks show that the direct and moderating effects are more pronounced in countries with greater CMI, suggesting that greater CMI requires stronger risk mitigation. Heterogeneity analysis reveals the moderating effect of risks on the impact of CML on CMI differs significantly between developed and developing countries, with developing countries facing a more urgent need for climate risk management.

全球大多数国家已经通过了气候立法来应对气候变化的挑战。本文利用1995年至2022年130个国家的小组研究,考虑了国家风险(即经济风险、金融风险、政治风险和气候物理风险)在影响气候减缓立法(CML)与气候减缓创新(cmi)之间关系方面的作用。研究结果表明,CML通常促进CMI。然而,调节效应表明,国家风险可能削弱CML对CMI的积极影响,强调了将风险管理纳入立法框架以推动CMI的重要性。不对称检验表明,在CMI较高的国家,直接和缓和效应更为明显,这表明CMI较高需要更有力的风险缓解。异质性分析显示,发达国家和发展中国家风险对CML对CMI影响的调节作用存在显著差异,发展中国家对气候风险管理的需求更为迫切。
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引用次数: 0
Impact of the Ripple Effect on the Resilience of Multimodal Container Port Operations: A System Dynamics Simulation Approach. 连锁反应对多式联运集装箱港口运营弹性的影响:系统动力学仿真方法。
IF 3.3 3区 医学 Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS Pub Date : 2025-12-01 Epub Date: 2025-11-21 DOI: 10.1111/risa.70149
Jinglin Zhang, Xuri Xin, Rameshwar Dubey, Trung Thanh Nguyen, Xiaoning Shi, Na Li, Zaili Yang

Current assessments of port resilience primarily focus on the risks affecting its operations, often neglecting the ripple effects across different subsystems within a port. In multimodal container ports, these sub-systems include liner shipping, feeder shipping, railways, and trucking. Moreover, prevailing research predominantly addresses port resilience from a macro perspective without detailing micro-level operational concerns. This article proposes a new integrated methodology that not only considers but also quantifies the ripple effects across different multimodal sub-systems and their impact on overall port resilience. It employs real operational and accident data to assess the resilience of a multimodal container port under different disruption scenarios, hence providing valuable insights into preventing systemic failures through targeted interventions at the subsystem level. The proposed methodology comprises three principal components: a system dynamics (SD) simulation that integrates variables and factors affecting port resilience, a resilience analysis model that converts system performance into a resilience metric based on three fundamental criteria, and a comprehensive port system resilience assessment utilizing Evidential Reasoning (ER). Each step, from the detailed simulation model reflecting micro-level mechanisms to aggregating information across subsystems, builds toward determining the port's overall resilience. Multiple disruptive scenarios are designed and derived from historical failures and field investigations to validate the effectiveness of the proposed methodology. The results demonstrate that the proposed approach effectively assesses port performance under disruptions, identifies critical subsystems, and supports timely recovery strategies. Applicable to other port systems, this approach offers essential insights for improving long-term resilience in container port operations.

目前对港口弹性的评估主要集中在影响其运营的风险上,往往忽略了港口内不同子系统之间的连锁反应。在多式联运集装箱港口,这些子系统包括班轮运输、支线运输、铁路和卡车运输。此外,目前的研究主要是从宏观角度解决港口弹性问题,而没有详细说明微观层面的操作问题。本文提出了一种新的综合方法,不仅考虑而且量化了不同多式联运子系统之间的连锁反应及其对整体港口弹性的影响。它采用真实的操作和事故数据来评估多式联运集装箱港口在不同中断情况下的恢复能力,从而通过子系统级别的有针对性干预,为防止系统故障提供有价值的见解。提出的方法包括三个主要组成部分:集成影响港口弹性的变量和因素的系统动力学(SD)模拟,将系统性能转换为基于三个基本标准的弹性度量的弹性分析模型,以及利用证据推理(ER)的综合港口系统弹性评估。从反映微观机制的详细仿真模型到跨子系统的信息聚合,每一步都是为了确定港口的整体弹性而构建的。从历史失败和实地调查中设计和导出了多个破坏性场景,以验证所提出方法的有效性。结果表明,所提出的方法可以有效地评估港口在中断下的性能,识别关键子系统,并支持及时的恢复策略。该方法适用于其他港口系统,为提高集装箱港口运营的长期弹性提供了重要见解。
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引用次数: 0
Systems Modeling and Policy Implications of Reducing the Workforce of the US Federal Government. 减少美国联邦政府劳动力的系统建模和政策含义。
IF 3.3 3区 医学 Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS Pub Date : 2025-12-01 DOI: 10.1111/risa.70150
Arhan Menta, Joost Santos

Workforce reductions, such as those implemented by the Department of Government Efficiency, can have far-reaching effects that extend beyond immediate job losses. This study employs a systems-based modeling approach, combining traditional Input-Output (IO) analysis with the inoperability Input-Output Model (IIM), to investigate how staffing cuts impact economic activity and erode institutional functions across interconnected sectors. The study reveals that reductions in federal staff have a significant impact on industries that rely heavily on government contracts and infrastructure, including aerospace, transportation, and high-tech services. These disruptions create ripple effects throughout supply networks and regional economies, resulting in delays, cancellations, and reduced operational capacity. Notably, the extent and pattern of losses identified here align with findings from independent reports, which highlight hidden costs such as declines in productivity, contract terminations, and maintenance backlogs that often offset the expected savings from workforce reductions. Unlike models that only focus on output, the IIM framework captures functional degradation, providing a more accurate breakdown of impacts on various economic sectors. These findings underscore the limitations of cost-cutting measures that overlook systemic interdependencies, highlighting the need for policies that strike a balance between fiscal objectives and institutional resilience. An adaptive, risk-aware approach to workforce planning can help maintain essential services while managing organizational change.

政府效率部(Department of Government Efficiency)实施的裁员,可能会产生深远的影响,而不仅仅是直接的失业。本研究采用基于系统的建模方法,将传统的投入产出(IO)分析与不可操作性投入产出模型(IIM)相结合,调查裁员如何影响经济活动,并侵蚀相互关联部门的制度功能。研究显示,联邦雇员的减少对严重依赖政府合同和基础设施的行业有重大影响,包括航空航天、运输和高科技服务。这些中断在整个供应网络和区域经济中产生连锁反应,导致延迟、取消和运营能力降低。值得注意的是,本文确定的损失程度和模式与独立报告的调查结果一致,这些报告强调了隐性成本,如生产率下降、合同终止和维护积压,这些成本往往抵消了裁员带来的预期节省。与只关注产出的模型不同,IIM框架捕捉到了功能退化,对不同经济部门的影响提供了更准确的细分。这些发现强调了忽视系统相互依赖性的成本削减措施的局限性,强调了在财政目标和制度弹性之间取得平衡的政策的必要性。适应性的、风险意识的劳动力规划方法可以帮助在管理组织变更的同时维持基本服务。
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引用次数: 0
The Psychological Distance of Modern Slavery Risk. 现代奴隶制风险的心理距离。
IF 3.3 3区 医学 Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS Pub Date : 2025-11-01 Epub Date: 2025-10-12 DOI: 10.1111/risa.70110
M Selim Cakir, Jamie K Wardman, Alexander Trautrims

Modern slavery has become recognized as one of the world's great human rights challenges due to the high prevalence of coercive labor exploitation associated with the production and consumption of many goods and services across the globe. Yet, while its practice is commonly considered to be "unseen" and far removed from many people's everyday lives and working experiences, the micro-level bases of individual perceptions and actions taken in response to this "distal" threat remain poorly understood. In this paper, we develop and test a model linking the "psychological distance of modern slavery risk" to individual concerns, ethical organizational climate, and intentions to engage in mitigating behaviors in the workplace. Results from a survey of 511 working adults from UK businesses show that "closer" psychological distance to modern slavery is associated with higher levels of concern and greater intention to act in response to this risk. We also find that ethical climate moderates the impact of modern slavery risk concerns on intentions to engage in mitigating behaviors. Our study findings, therefore, complement existing research by pinpointing the key roles of psychological distance and ethical climate in modern slavery risk responses and highlighting the potential for micro-level interventions to help promote antislavery action.

由于与全球许多商品和服务的生产和消费相关的强制性劳动剥削的普遍存在,现代奴隶制已被公认为世界上最大的人权挑战之一。然而,尽管它的实践通常被认为是“看不见的”,远离许多人的日常生活和工作经验,但对个人感知和应对这种“远端”威胁所采取的行动的微观基础仍然知之甚少。在本文中,我们开发并测试了一个模型,该模型将“现代奴役风险的心理距离”与个人关注、道德组织氛围和参与工作场所减轻行为的意图联系起来。一项针对英国商界511名在职成年人的调查结果显示,与现代奴隶制“更近”的心理距离与更高程度的担忧和更大的行动意愿有关。我们还发现,道德气候缓和了现代奴隶制风险关注对参与缓解行为意图的影响。因此,我们的研究结果补充了现有的研究,指出了心理距离和道德氛围在现代奴隶制风险反应中的关键作用,并强调了微观层面干预的潜力,以帮助促进反奴隶制行动。
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引用次数: 0
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