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Optimal sampling strategy for probability estimation: An application to the Agricultural Quarantine Inspection Monitoring program. 概率估计的最优抽样策略:农业检疫检验监测计划的应用。
IF 3 3区 医学 Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS Pub Date : 2024-11-10 DOI: 10.1111/risa.17669
Huidi Ma, Benjamin D Leibowicz, John J Hasenbein

Imported agricultural pests can cause substantial damage to agriculture, food security, and ecosystems. In the United States, the Agricultural Quarantine Inspection Monitoring (AQIM) program conducts random sampling to estimate the probabilities that cargo and passengers arriving at ports of entry carry pests. Assessing these risks accurately is critical to enable effective policies and operational procedures. This study introduces a pathway-level analysis with an objective function aligned with AQIM's goal, offering a new perspective compared to the current container-by-container approach, which relies on heuristics to set inspection rates. We formulate an optimization model that minimizes the mean squared error of the probability estimates that AQIM obtains. The central decision-making tradeoff that the model explores is whether it is preferable to sample more arriving containers (and fewer boxes per container) or more boxes per container (and fewer containers), given limited resources. We first derive an analytical solution for the optimal sampling strategy by leveraging several approximations. Then, we apply our model to a numerical case study of maritime cargo sampling at the Port of Long Beach. Across a wide range of parameter settings, the optimal strategy samples more containers (but fewer boxes per container) than the current AQIM protocol. The difference between the two strategies and the accuracy improvement with the optimal approach are larger if the pest statuses of boxes in the same container are more strongly correlated. We recommend that AQIM record box-level (beyond only container-level) inspection data, which could be used to estimate this correlation and other model parameters.

进口农业害虫可对农业、粮食安全和生态系统造成重大损害。在美国,农业检疫检验监测(AQIM)计划通过随机抽样来估计抵达入境口岸的货物和旅客携带有害生物的概率。准确评估这些风险对于制定有效的政策和操作程序至关重要。本研究引入了路径级分析,其目标函数与 AQIM 的目标一致,与目前依赖启发式方法设定检查率的逐集装箱方法相比,提供了一个新的视角。我们制定了一个优化模型,使 AQIM 获得的概率估计的均方误差最小化。该模型探讨的核心决策权衡问题是,在资源有限的情况下,是对更多到达的集装箱(每个集装箱的箱数较少)进行抽样,还是对每个集装箱的箱数较多(集装箱数量较少)进行抽样。我们首先利用几种近似方法推导出最优采样策略的分析解决方案。然后,我们将模型应用于长滩港海运货物抽样的数值案例研究。在各种参数设置下,最优策略比当前的 AQIM 协议采样更多的集装箱(但每个集装箱采样的箱数更少)。如果同一集装箱内箱子的虫害状态相关性较强,则两种策略之间的差异和最优方法的准确性提高幅度会更大。我们建议 AQIM 记录箱级(而不仅仅是集装箱级)检查数据,这些数据可用于估算这种相关性和其他模型参数。
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引用次数: 0
The need for general adaptive capacity-Discussing resilience with complex adaptive systems theory. 对一般适应能力的需求--用复杂适应系统理论讨论复原力。
IF 3 3区 医学 Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS Pub Date : 2024-11-10 DOI: 10.1111/risa.17676
Benjamin Scharte

The concept of resilience intrinsically links with both complexity and adaptive capacity. Scholars from different fields agree on this. Still, the detailed relations between resilience, complexity, and adaptive capacity need a more thorough theoretical analysis. This article analyses resilience with the help of assumptions from complex adaptive systems (CAS) theory to answer two questions in more detail: What is the relation between resilience and complexity? How can adaptive capacity contribute to resilience? By applying basic ideas from CAS theory to the resilience discourse, the article deduces that complexity of a system is a necessary condition for resilience because complex systems consist of agents that possess adaptive capacity, whereas simple systems consist of mere elements that cannot adapt to unexpected disruptions. The relation between complexity and resilience is multidimensional. Growing complexity leads to a growing need for resilience because the chances for severe, unexpected disruptions increase. The analysis of adaptive capacities revealed that systems and the agents they consist of can possess of specialized and general adaptive capacity. General adaptive capacity is the core feature of resilience because it enables systems to cope with unexpected disruptions. System design principles such as diversity within functional groups and redundancy help to increase general adaptive capacity. The same is true on the community level for social capital and on the individual level for disaster preparedness measures because they increase coping capacities independent of specific hazards.

复原力的概念与复杂性和适应能力有着内在联系。来自不同领域的学者对此达成了共识。不过,复原力、复杂性和适应能力之间的具体关系还需要更深入的理论分析。本文借助复杂适应系统(CAS)理论的假设对复原力进行分析,以更详细地回答两个问题:复原力与复杂性之间的关系是什么?适应能力如何促进复原力?通过将复杂适应系统理论的基本思想应用于复原力的论述,文章推断出系统的复杂性是复原力的必要条件,因为复杂系统由拥有适应能力的主体组成,而简单系统仅由无法适应意外干扰的要素组成。复杂性与复原力之间的关系是多方面的。复杂性的增加导致对复原力的需求增加,因为发生严重的意外破坏的可能性增加。对适应能力的分析表明,系统及其组成要素可以拥有专门适应能力和一般适应能力。一般适应能力是复原力的核心特征,因为它能使系统应对意想不到的破坏。系统设计原则,如功能组内的多样性和冗余,有助于提高一般适应能力。在社区层面的社会资本和个人层面的备灾措施也是如此,因为它们能提高应对能力,而不受具体危害的影响。
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引用次数: 0
Decoding derogation: The impact of environmental values and political ideology on the effect of persuasive message about recycle and reuse behaviors. 解码贬损:环境价值观和政治意识形态对有关回收和再利用行为的说服信息效果的影响。
IF 3 3区 医学 Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS Pub Date : 2024-11-10 DOI: 10.1111/risa.17674
Prerna Shah, Janet Z Yang

Although persuasive messages are designed to motivate individuals to engage in intended behaviors, they do not always work. Often, people follow previously established values and ideologies and dismiss persuasive messages. We examine how participants react to a persuasive message related to plastic pollution and how these reactions shape their willingness to recycle and reuse. Results indicate that environmental values and political ideology are associated with message derogation in distinct ways, which, in turn, affect risk perception, self-efficacy, and intention to recycle and reuse. Further, past behavior moderates the relationship between message derogation and perceived risk, but not the relationship between message derogation and self-efficacy. These results suggest that pre-existing values and ideologies play an important role in message derogation, a hitherto under-researched phenomenon that has key implications for self-reported behavioral change. Moreover, past behavior could serve as a powerful lever in steering risk perception and behavioral intent.

尽管劝说性信息的目的是激励个人参与预期行为,但它们并不总是奏效。通常,人们会遵循先前确立的价值观和意识形态,而对劝说性信息不屑一顾。我们研究了参与者对有关塑料污染的劝说信息的反应,以及这些反应如何影响他们回收和再利用的意愿。结果表明,环境价值观和政治意识形态以不同的方式与信息贬损相关联,进而影响风险认知、自我效能以及回收和再利用的意愿。此外,过去的行为会调节信息贬损与感知风险之间的关系,但不会调节信息贬损与自我效能之间的关系。这些结果表明,已有的价值观和意识形态在信息贬损中起着重要作用,而这一现象迄今为止还未得到充分研究,它对自我报告的行为改变有着重要影响。此外,过去的行为可以成为引导风险认知和行为意向的有力杠杆。
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引用次数: 0
Benchmark dose modeling for epidemiological dose-response assessment using case-control studies. 利用病例对照研究进行流行病学剂量反应评估的基准剂量模型。
IF 3 3区 医学 Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS Pub Date : 2024-11-03 DOI: 10.1111/risa.17671
Francesco De Pretis, Yun Zhou, Kan Shao

Following a previous article that focused on integrating epidemiological data from prospective cohort studies into toxicological risk assessment, this paper shifts the focus to case-control studies. Specifically, it utilizes the odds ratio (OR) as the main epidemiological measure, aligning it with the benchmark dose (BMD) methodology as the standard dose-response modeling approach to determine chemical toxicity values for regulatory risk assessment. A standardized BMD analysis framework has been established for toxicological data, including input data requirements, dose-response models, definitions of benchmark response, and consideration of model uncertainty. This framework has been enhanced by recent methods capable of handling both cohort and case-control studies using summary data that have been adjusted for confounders. The present study aims to investigate and compare the "effective count" based BMD modeling approach, merged with an algorithm used for converting odds ratio to relative risk in cohort studies with partial data information (i.e., the Wang algorithm), with the adjusted OR-based BMD analysis approach. The goal is to develop an adequate BMD modeling framework that can be generalized for analyzing published case-control study data. As in the previous study, these methods were applied to a database examining the association between bladder and lung cancer and inorganic arsenic exposure. The results indicate that estimated BMDs and BMDLs are relatively consistent across both methods. However, modeling adjusted OR values as continuous data for BMD estimation aligns better with established practices in toxicological BMD analysis, making it a more generalizable approach.

上一篇文章重点介绍了如何将前瞻性队列研究的流行病学数据纳入毒理学风险评估,本文将重点转向病例对照研究。具体来说,本文采用了几率比(OR)作为主要的流行病学测量方法,并将其与基准剂量(BMD)方法相结合,将其作为标准的剂量-反应建模方法,用于确定监管风险评估中的化学毒性值。目前已为毒理学数据建立了标准化的基准剂量分析框架,包括输入数据要求、剂量-反应模型、基准反应定义以及对模型不确定性的考虑。最近的一些方法对这一框架进行了改进,这些方法能够使用经过混杂因素调整的汇总数据来处理队列研究和病例对照研究。本研究旨在调查和比较基于 "有效计数 "的 BMD 建模方法,该方法与用于在具有部分数据信息的队列研究中将几率比例转换为相对风险的算法(即 Wang 算法)相结合,并与基于调整 OR 的 BMD 分析方法相结合。目的是建立一个适当的 BMD 建模框架,该框架可用于分析已发表的病例对照研究数据。与之前的研究一样,这些方法被应用于一个数据库,该数据库研究了膀胱癌和肺癌与无机砷暴露之间的关系。结果表明,两种方法估计的 BMD 和 BMDL 相对一致。不过,将调整后的 OR 值作为连续数据建模来估算 BMD 更符合毒理学 BMD 分析的既定做法,因此是一种更具普遍性的方法。
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引用次数: 0
The lasting effect of the Romantic view of nature: How it influences perceptions of risk and the support of symbolic actions against climate change. 浪漫主义自然观的持久影响:浪漫主义自然观如何影响人们对风险的认识以及对气候变化象征性行动的支持。
IF 3 3区 医学 Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS Pub Date : 2024-11-03 DOI: 10.1111/risa.17672
Michael Siegrist, Anne Berthold

Culture can have a major impact on how we perceive different hazards. In the Romantic period, nature was described and portrayed as mysterious and benevolent. A deep connection to nature was perceived as important. We proposed that this romantic view would be positively related to people's risk perceptions of man-made hazards and, more specifically, to concerns about climate change. Further, we hypothesized that the Romantic perception of nature leads to a biased perception of natural hazards and that the moral component of action is of particular importance above and beyond the mere efficacy of the action. We conducted an online survey in Germany (N = 531), a country where Romanticism had a very widespread influence. The study shows that individuals with a Romantic view of nature perceived greater risks associated with climate change than those without such a view. In addition, those with a Romantic view of nature were more likely to support measures to reduce the risks of climate change, even when it is said that such measures are not effective. Finally, the study found a significantly higher positive correlation between Romantic views of nature and risk perceptions of man-made versus natural hazards. The results suggest that ideas developed during the Romantic era continue to influence hazard perception in Germany.

文化会对我们如何看待不同的危险产生重大影响。在浪漫主义时期,大自然被描述和描绘成神秘而仁慈的。人们认为与大自然的深层联系非常重要。我们提出,这种浪漫主义观点将与人们对人为灾害的风险认知正相关,更具体地说,与对气候变化的担忧正相关。此外,我们还假设,浪漫主义的自然观会导致人们对自然灾害的认识出现偏差,而行动中的道德因素尤为重要,它超越了单纯的行动效果。我们在浪漫主义影响广泛的德国(N = 531)进行了一项在线调查。研究结果表明,具有浪漫主义自然观的人比没有浪漫主义自然观的人认为气候变化带来的风险更大。此外,具有浪漫主义自然观的人更倾向于支持减少气候变化风险的措施,即使据说这些措施并不有效。最后,研究发现,浪漫主义自然观与对人为灾害和自然灾害的风险认知之间的正相关性明显更高。研究结果表明,浪漫主义时期形成的观念继续影响着德国人对灾害的认知。
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引用次数: 0
Evidence and uncertainty: An info-gap analysis of uncertainty-augmenting evidence. 证据与不确定性:不确定性证据的信息差距分析。
IF 3 3区 医学 Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS Pub Date : 2024-11-01 Epub Date: 2024-06-06 DOI: 10.1111/risa.14346
Yakov Ben-Haim

Decisions in many disciplines are based on understanding and evidence. More evidence is better than less when it enhances the decision-maker's understanding. This is achieved by reducing uncertainty confronting the decision-maker and reducing the potential for misunderstanding and failure. However, some evidence may actually augment uncertainty by revealing prior error or ignorance. True evidence that augments uncertainty is important because it identifies inadequacies of current understanding and may suggest directions for rectifying this. True evidence that reduces uncertainty may simply reconfirm or strengthen prior understanding. Uncertainty-augmenting evidence, when it is true, can support the expansion of one's previously incomplete understanding. A dilemma arises because both reduction and enhancement of uncertainty can be beneficial, and both are not simultaneously possible on the same issue. That is, uncertainty can be either pernicious or propitious. Info-gap theory provides a response. The info-gap robustness function enables protection against pernicious uncertainty by inhibiting failure. The info-gap opportuneness function enables exploitation of propitious uncertainty by facilitating wonderful windfall outcomes. The dilemma of uncertainty-augmenting evidence is that robustness and opportuneness are in conflict; a decision that enhances one, worsens the other. This antagonism between robustness and opportuneness-between protecting against pernicious uncertainty and exploiting propitious uncertainty-is characterized in a generic proposition and corollary. These results are illustrated in an example of allocation of limited resources.

许多学科的决策都以理解和证据为基础。当证据能增强决策者的理解力时,证据越多越好。要做到这一点,就要减少决策者面临的不确定性,降低误解和失败的可能性。然而,有些证据实际上可能会通过揭示先前的错误或无知而增加不确定性。增加不确定性的真凭实据之所以重要,是因为它能发现当前认识的不足之处,并提出纠正方向。减少不确定性的真实证据可能只是再次确认或加强先前的理解。增加不确定性的证据,如果是真实的,则可以支持扩展人们之前不完整的理解。由于减少不确定性和增加不确定性都可能带来好处,而在同一问题上两者又不可能同时出现,因此出现了两难的局面。也就是说,不确定性既可能是有害的,也可能是有利的。信息差距理论提供了一种应对方法。信息差距稳健性功能通过抑制失败来防止有害的不确定性。信息差距的机会性功能则通过促进美妙的意外结果来利用有利的不确定性。增强不确定性证据的困境在于,稳健性和机会性之间存在冲突;增强其中一个的决策会恶化另一个。稳健性和机会性之间的这种对立--防止有害的不确定性和利用有利的不确定性之间的对立--在一个通用命题和推论中得到了描述。这些结果在一个有限资源分配的例子中得到了说明。
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引用次数: 0
The relationship between freight train length and the risk of derailment. 货运列车长度与脱轨风险之间的关系。
IF 3 3区 医学 Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS Pub Date : 2024-11-01 Epub Date: 2024-05-28 DOI: 10.1111/risa.14312
Peter M Madsen, Robin L Dillon, Konstantinos P Triantis, Joseph A Bradley

In recent years, longer and heavier trains have become more common, primarily driven by efficiency and cost-saving measures in the railroad industry. Regulation of train length is currently under consideration in the United States at both the federal and state levels, because of concerns that longer trains may have a higher risk of derailment, but the relationship between train length and risk of derailment is not yet well understood. In this study, we use data on freight train accidents during the 2013-2022 period from the Federal Railroad Administration (FRA) Rail Equipment Accident and Highway-Rail Grade Crossing Accident databases to estimate the relationship between freight train length and the risk of derailment. We determine that longer trains do have a greater risk of derailment. Based on our analysis, running 100-car trains is associated with 1.11 (95% confidence interval: 1.10-1.12) times the derailment odds of running 50-car trains (or a 11% increase), even accounting for the fact that only half as many 100-car trains would need to run. For 200-car trains, the odds increase by 24% (odds ratio 1.24, 95% confidence interval: 1.20-1.28), again accounting for the need for fewer trains. Understanding derailment risk is an important component for evaluating the overall safety of the rail system and for the future development and regulation of freight rail transportation. Given the limitations of the current data on freight train length, this study provides an important step toward such an understanding.

近年来,火车越来越长、越来越重,这主要是受铁路行业提高效率和节约成本措施的影响。目前,美国联邦和各州都在考虑对列车长度进行监管,因为人们担心更长的列车可能会有更高的脱轨风险,但人们对列车长度与脱轨风险之间的关系还不甚了解。在本研究中,我们利用联邦铁路管理局(FRA)铁路设备事故和公路铁路道口事故数据库中 2013-2022 年期间的货运列车事故数据,估算货运列车长度与脱轨风险之间的关系。我们确定,较长的列车脱轨风险确实较大。根据我们的分析,即使考虑到只需运行一半的 100 卡列车,运行 100 卡列车的脱轨几率也是运行 50 卡列车的 1.11 倍(95% 置信区间:1.10-1.12)(或增加 11%)。对于 200 节车厢的列车,出轨几率增加了 24%(几率比 1.24,95% 置信区间:1.20-1.28),同样考虑到了列车数量减少的需要。了解脱轨风险是评估铁路系统整体安全性以及未来发展和监管货运铁路运输的重要组成部分。鉴于目前货运列车长度数据的局限性,本研究为实现这一认识迈出了重要一步。
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引用次数: 0
Pairwise summation as a method for the additive combination of probabilities in qualitative risk assessments. 配对求和法作为定性风险评估中概率加法组合的一种方法。
IF 3 3区 医学 Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS Pub Date : 2024-11-01 Epub Date: 2024-05-22 DOI: 10.1111/risa.14323
Matteo Crotta, Eleonora Chinchio, Vito Tranquillo, Nicola Ferrari, Javier Guitian

Qualitative frameworks are widely employed to tackle urgent animal or public health issues when data are scarce and/or urgent decisions need to be made. In qualitative models, the degree of belief regarding the probabilities of the events occurring along the risk pathway(s) and the outcomes is described in nonnumerical terms, typically using words such as Low, Medium, or High. The main methodological challenge, intrinsic in qualitative models, relates to performing mathematical operations and adherence to the rule of probabilities when probabilities are nonnumerical. Although methods to obtain the qualitative probability from the conditional realization of n events are well-established and consistent with the multiplication rule of probabilities, there is a lack of accepted methods for addressing situations where the probability of an event occurring can increase, and the rule of probability P(AUB) = P(A) + P(B) - P(A∩B) should apply. In this work, we propose a method based on the pairwise summation to fill this methodological gap. Our method was tested on two qualitative models and compared by means of scenario analysis to other approaches found in literature. The qualitative nature of the models prevented formal validation; however, when using the pairwise summation, results consistently appeared more coherent with probability rules. Even if the final qualitative estimate can only represent an approximation of the actual probability of the event occurring, qualitative models have proven to be effective in providing scientific-based evidence to support decision-making. The method proposed in this study contributes to reducing the subjectivity that characterizes qualitative models, improving transparency and reproducibility.

在数据稀缺和/或需要紧急决策时,定性框架被广泛用于解决紧急动物或公共卫生问题。在定性模型中,对风险路径上发生的事件和结果的概率的相信程度用非数字术语来描述,通常使用低、中或高等词。定性模型所固有的主要方法论挑战是,当概率是非数字时,如何进行数学运算和遵守概率规则。虽然从 n 个事件的条件实现中获得定性概率的方法已经得到公认,并且符合概率的乘法规则,但在事件发生的概率可能增加的情况下,还缺乏公认的方法来处理这种情况,而概率规则 P(AUB) = P(A) + P(B) - P(A∩B) 应该适用。在这项工作中,我们提出了一种基于成对求和的方法来填补这一方法空白。我们的方法在两个定性模型上进行了测试,并通过情景分析与文献中的其他方法进行了比较。由于模型的定性性质,无法进行正式验证;然而,当使用成对求和法时,结果始终与概率规则更加一致。即使最终的定性估计只能代表事件发生的实际概率的近似值,但定性模型已被证明可以有效地为决策提供科学依据。本研究提出的方法有助于减少定性模型的主观性,提高透明度和可重复性。
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引用次数: 0
The exposure of nonhuman living organisms to mobile communication emissions: A survey to establish European stakeholders' policy option preferences. 非人类生物暴露于移动通信辐射:一项旨在确定欧洲利益相关者政策选择偏好的调查。
IF 3 3区 医学 Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS Pub Date : 2024-11-01 Epub Date: 2024-05-22 DOI: 10.1111/risa.14322
Laura Recuero Virto, Arno Thielens, Marek Czerwiński, Jérémy Froidevaux

There is an unprecedented exposure of living organisms to mobile communications radiofrequency electromagnetic field (RF-EMF) emissions. Guidelines on exposure thresholds to limit thermal effects from these emissions are restricted to humans. However, tissue heating can occur in all living organisms that are exposed. In addition, exposure at millimetric frequencies used by 5G may impact surface tissues and organs of plants and small-size species. It is also expected that the addition of 5G to existing networks will intensify radiofrequency absorption by living organisms. A European Parliament report proposed policy options on the effects of RF-EMF exposure of plants, animals, and other living organisms in the context of 5G: funding more research, implementing monitoring networks, accessing more information from operators on antennas and EMF emissions, and developing compliance studies when antennas are installed. However, there is no evidence on the preferences of relevant stakeholders regarding these policy options. This paper reports the findings of a survey of key European stakeholders' policy option preferences based on the European Parliament's report. It reveals a broad consensus on funding more research on the effects of exposure of plants, animals, and other living organisms to EMFs. It also highlights the need for deliberation concerning the other policy options that could provide solutions for regulatory authorities, central administrations, the private sector, nongovernmental associations and advocates, and academics. Such deliberation would pave the way for effective solutions, focusing on long-term output from funding research, and enabling short-term socially and economically acceptable actions for all parties concerned.

生物体暴露在移动通信射频电磁场(RF-EMF)辐射中的情况前所未有。有关限制这些辐射热效应的暴露阈值准则仅限于人类。然而,所有生物体在暴露后都可能出现组织发热。此外,暴露于 5G 使用的毫米级频率可能会影响植物和小型物种的表面组织和器官。预计在现有网络中增加 5G 还将加强生物体对射频的吸收。欧洲议会的一份报告就 5G 对植物、动物和其他生物体的射频电磁场暴露影响提出了政策选择:资助更多研究、实施监测网络、从运营商处获取更多有关天线和电磁场辐射的信息,以及在安装天线时开展合规性研究。然而,目前还没有证据表明相关利益方对这些政策选择的偏好。本文报告了根据欧洲议会报告对欧洲主要利益相关者的政策选择偏好进行调查的结果。调查显示,在资助更多有关植物、动物和其他生物体暴露于电磁场影响的研究方面,各方已达成广泛共识。报告还强调,有必要就其他政策选项进行讨论,以便为监管机构、中央行政部门、私营部门、非政府协会和倡导者以及学术界提供解决方案。这种讨论将为有效的解决方案铺平道路,注重资助研究的长期产出,并使有关各方能够采取社会和经济上可接受的短期行动。
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引用次数: 0
Research gaps and priorities for quantitative microbial risk assessment (QMRA). 微生物定量风险评估 (QMRA) 的研究空白和重点。
IF 3 3区 医学 Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS Pub Date : 2024-11-01 Epub Date: 2024-05-21 DOI: 10.1111/risa.14318
Kerry A Hamilton, Joanna Ciol Harrison, Jade Mitchell, Mark Weir, Marc Verhougstraete, Charles N Haas, A Pouyan Nejadhashemi, Julie Libarkin, Tiong Gim Aw, Kyle Bibby, Aaron Bivins, Joe Brown, Kara Dean, Gwyneth Dunbar, Joseph N S Eisenberg, Monica Emelko, Daniel Gerrity, Patrick L Gurian, Emma Hartnett, Michael Jahne, Rachael M Jones, Timothy R Julian, Hongwan Li, Yanbin Li, Jacqueline MacDonald Gibson, Gertjan Medema, J Scott Meschke, Alexis Mraz, Heather Murphy, David Oryang, Emmanuel de-Graft Johnson Owusu-Ansah, Emily Pasek, Abani K Pradhan, Maria Tereza Pepe Razzolini, Michael O Ryan, Mary Schoen, Patrick W M H Smeets, Jeffrey Soller, Helena Solo-Gabriele, Clinton Williams, Amanda M Wilson, Amy Zimmer-Faust, Jumana Alja'fari, Joan B Rose

The coronavirus disease 2019 pandemic highlighted the need for more rapid and routine application of modeling approaches such as quantitative microbial risk assessment (QMRA) for protecting public health. QMRA is a transdisciplinary science dedicated to understanding, predicting, and mitigating infectious disease risks. To better equip QMRA researchers to inform policy and public health management, an Advances in Research for QMRA workshop was held to synthesize a path forward for QMRA research. We summarize insights from 41 QMRA researchers and experts to clarify the role of QMRA in risk analysis by (1) identifying key research needs, (2) highlighting emerging applications of QMRA; and (3) describing data needs and key scientific efforts to improve the science of QMRA. Key identified research priorities included using molecular tools in QMRA, advancing dose-response methodology, addressing needed exposure assessments, harmonizing environmental monitoring for QMRA, unifying a divide between disease transmission and QMRA models, calibrating and/or validating QMRA models, modeling co-exposures and mixtures, and standardizing practices for incorporating variability and uncertainty throughout the source-to-outcome continuum. Cross-cutting needs identified were to: develop a community of research and practice, integrate QMRA with other scientific approaches, increase QMRA translation and impacts, build communication strategies, and encourage sustainable funding mechanisms. Ultimately, a vision for advancing the science of QMRA is outlined for informing national to global health assessments, controls, and policies.

2019 年冠状病毒疾病大流行凸显了更快速、更常规地应用定量微生物风险评估(QMRA)等建模方法来保护公众健康的必要性。QMRA 是一门致力于了解、预测和减轻传染病风险的跨学科科学。为了让 QMRA 研究人员更好地为政策和公共卫生管理提供信息,我们举办了 QMRA 研究进展研讨会,以总结 QMRA 研究的前进方向。我们总结了 41 位 QMRA 研究人员和专家的见解,通过以下方式阐明 QMRA 在风险分析中的作用:(1)确定关键研究需求;(2)强调 QMRA 的新兴应用;(3)描述数据需求和关键科学工作,以改进 QMRA 科学。确定的主要研究重点包括:在 QMRA 中使用分子工具、推进剂量-反应方法、解决所需的暴露评估、协调 QMRA 的环境监测、统一疾病传播和 QMRA 模型之间的分界线、校准和/或验证 QMRA 模型、共同暴露和混合物建模,以及将变异性和不确定性纳入整个 "从源到果 "过程的标准化实践。已确定的跨领域需求包括:发展研究与实践社区、将 QMRA 与其他科学方法相结合、提高 QMRA 的转化率和影响力、建立沟通战略以及鼓励可持续的供资机制。最后,概述了推进 QMRA 科学的愿景,以便为国家到全球的健康评估、控制和政策提供信息。
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Risk Analysis
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