Pub Date : 2025-02-18DOI: 10.1093/schbul/sbaf007.038
Jinmeng Ma
Background Postoperative cognitive dysfunction (POCD) is a common complication in elderly patients, showing a decline in memory, attention and executive function, which affects the quality of life and recovery. Exosomes, as mediators of cell-cell communication, have attracted much attention in neurological diseases, which contain a variety of bioactive molecules that can participate in the CNS regulation through the blood-brain barrier. Currently, the function and mechanism of exosomes in POCD remain unclear. The study will explore the role of exosome in POCD through animal experiments and molecular biology techniques, and provide new targets for clinical intervention. Methods Healthy adult male C57BL/6 mice weighing 20-25g were divided into Sham group (n=20), POCD group (n=30), and POCD intervention group (n=30). The POCD model was constructed by common carotid artery ligation and isoflurane anesthesia. Spatial learning and memory abilities were assessed on postoperative days 1,3, and 7 using the Morris water maze (MWM). After the experiment, the distribution in the brain of fluorescently labeled exosomes was visualized by tail vein injection, and the expression of miRNA and key proteins in the exosomes was analyzed by Reverse Transcription Quantitative Polymerase Chain Reaction (RT-qPCR) and proteomics techniques. The Western blot and immunofluorescence labeling techniques were used to verify the relationship between molecules and neuroinflammation in exosomes. Data were analyzed using the SPSS 26.0 software, and the differences between groups were compared by one-way analysis of variance (ANOVA). Results Comparison of the main indicators between the groups is shown in Table 1. Table 1 shows that mice in the POCD group had prolonged latency on postoperative days 1 and 3, shorter residence time in the target quadrant, and improved cognitive function in the intervention group. After exosome tail vein injection, the fluorescence signal was enhanced in the hippocampus, indicating that exosomes penetrate the blood-brain barrier. By RT-qPCR, inflammation-related miRNA expression was up-regulated in exosomes in the POCD group, with the expression decreased after intervention. Proteomic analysis showed that the expression of proteins related to IL-6, TNF- α, and NF- κ B signaling pathway was increased in exosomes in the POCD group, and decreased after intervention. Immunofluorescence showed that the proportion of Iba-1-positive microglia activation in the hippocampus of the POCD group was high and decreased after the intervention. Discussion The function and mechanism of exosomes in POCD were systematically investigated. The results indicate that exosomes can enter the CNS through the blood-brain barrier and affect neuroinflammation and cognitive function recovery in the hippocampus by regulating inflammation-related miRNA and protein expression. This provides new molecular targets and theoretical ale for POCD intervention. Future studies should furthe
{"title":"38 THE FUNCTION AND MECHANISM OF EXTRACELLULAR VESICLES IN POSTOPERATIVE COGNITIVE DYSFUNCTION","authors":"Jinmeng Ma","doi":"10.1093/schbul/sbaf007.038","DOIUrl":"https://doi.org/10.1093/schbul/sbaf007.038","url":null,"abstract":"Background Postoperative cognitive dysfunction (POCD) is a common complication in elderly patients, showing a decline in memory, attention and executive function, which affects the quality of life and recovery. Exosomes, as mediators of cell-cell communication, have attracted much attention in neurological diseases, which contain a variety of bioactive molecules that can participate in the CNS regulation through the blood-brain barrier. Currently, the function and mechanism of exosomes in POCD remain unclear. The study will explore the role of exosome in POCD through animal experiments and molecular biology techniques, and provide new targets for clinical intervention. Methods Healthy adult male C57BL/6 mice weighing 20-25g were divided into Sham group (n=20), POCD group (n=30), and POCD intervention group (n=30). The POCD model was constructed by common carotid artery ligation and isoflurane anesthesia. Spatial learning and memory abilities were assessed on postoperative days 1,3, and 7 using the Morris water maze (MWM). After the experiment, the distribution in the brain of fluorescently labeled exosomes was visualized by tail vein injection, and the expression of miRNA and key proteins in the exosomes was analyzed by Reverse Transcription Quantitative Polymerase Chain Reaction (RT-qPCR) and proteomics techniques. The Western blot and immunofluorescence labeling techniques were used to verify the relationship between molecules and neuroinflammation in exosomes. Data were analyzed using the SPSS 26.0 software, and the differences between groups were compared by one-way analysis of variance (ANOVA). Results Comparison of the main indicators between the groups is shown in Table 1. Table 1 shows that mice in the POCD group had prolonged latency on postoperative days 1 and 3, shorter residence time in the target quadrant, and improved cognitive function in the intervention group. After exosome tail vein injection, the fluorescence signal was enhanced in the hippocampus, indicating that exosomes penetrate the blood-brain barrier. By RT-qPCR, inflammation-related miRNA expression was up-regulated in exosomes in the POCD group, with the expression decreased after intervention. Proteomic analysis showed that the expression of proteins related to IL-6, TNF- α, and NF- κ B signaling pathway was increased in exosomes in the POCD group, and decreased after intervention. Immunofluorescence showed that the proportion of Iba-1-positive microglia activation in the hippocampus of the POCD group was high and decreased after the intervention. Discussion The function and mechanism of exosomes in POCD were systematically investigated. The results indicate that exosomes can enter the CNS through the blood-brain barrier and affect neuroinflammation and cognitive function recovery in the hippocampus by regulating inflammation-related miRNA and protein expression. This provides new molecular targets and theoretical ale for POCD intervention. Future studies should furthe","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":"6 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-18DOI: 10.1093/schbul/sbaf007.070
Jing Zhuang
Background Schizophrenia patients exhibit sensory and behavioral abnormalities, and the current common intervention treatment mainly uses drugs to block dopamine receptors in the brain. However, the cognitive function of patients with schizophrenia cannot be cured through medication. In current interventions for schizophrenia, vocal training therapy can regulate the patient’s breathing rhythm, maintain their heart rate and emotions, relax their mood and body, thereby increasing their resistance to stressful situations. Therefore, the study explored the positive effects of vocal training on cognitive function training in patients with schizophrenia. Methods A study was conducted on 150 patients with schizophrenia, who were evenly divided into a control group and an experimental group, with 75 patients in each group. The control group received routine nursing methods and the nursing time was maintained for 6 months. The experimental group added soothing vocal training activities on the basis of routine care, twice a week for 30 minutes each time. The same intervention lasted for 6 months in the experimental group. After intervention, Stroop color word test was used to evaluate patients’ cognitive function. Results The study will evaluate the cognitive function level of patients with schizophrenia based on the Stroop color word test results before and after intervention in the experimental and control groups. The specific results are shown in Table 1. From the table, it can be seen that the control group scored 97.32±1.27 and 97.87±1.40 before and after intervention in the A card test, respectively. The scores of the experimental group before and after intervention were 97.65±1.27 and 99.70±0.46, respectively. In the detection of the B card, the scores of the control group before and after intervention were 94.75±1.77 and 95.18±2.22, respectively, while the detection scores of the experimental group were 95.10±1.66 and 98.73±1.04, respectively. In the C card, the scores of the control group before and after intervention were 87.20±3.83 and 88.08±3.76, respectively. The scores of the experimental group before and after intervention were 86.53±3.55 and 95.60±2.12, respectively. From the data results, it can be seen that the experimental group showed a greater increase in Stroop color word test scores after intervention, indicating that vocal training can effectively improve cognitive function in patients with schizophrenia. Discussion The experimental results indicate that the intervention method of vocal training can improve patients’ thinking expression ability and memory by soothing their physical and mental health, and through vocal music. Through vocal training, patients with schizophrenia can enhance their self-identity through beautiful musical works and singing behavior, thereby improving their psychological state and cognitive function, enhancing their self-management level and quality of life.
{"title":"70 RESEARCH ON THE ROLE OF VOCAL TRAINING IN IMPROVING COGNITIVE FUNCTION OF PATIENTS WITH SCHIZOPHRENIA","authors":"Jing Zhuang","doi":"10.1093/schbul/sbaf007.070","DOIUrl":"https://doi.org/10.1093/schbul/sbaf007.070","url":null,"abstract":"Background Schizophrenia patients exhibit sensory and behavioral abnormalities, and the current common intervention treatment mainly uses drugs to block dopamine receptors in the brain. However, the cognitive function of patients with schizophrenia cannot be cured through medication. In current interventions for schizophrenia, vocal training therapy can regulate the patient’s breathing rhythm, maintain their heart rate and emotions, relax their mood and body, thereby increasing their resistance to stressful situations. Therefore, the study explored the positive effects of vocal training on cognitive function training in patients with schizophrenia. Methods A study was conducted on 150 patients with schizophrenia, who were evenly divided into a control group and an experimental group, with 75 patients in each group. The control group received routine nursing methods and the nursing time was maintained for 6 months. The experimental group added soothing vocal training activities on the basis of routine care, twice a week for 30 minutes each time. The same intervention lasted for 6 months in the experimental group. After intervention, Stroop color word test was used to evaluate patients’ cognitive function. Results The study will evaluate the cognitive function level of patients with schizophrenia based on the Stroop color word test results before and after intervention in the experimental and control groups. The specific results are shown in Table 1. From the table, it can be seen that the control group scored 97.32±1.27 and 97.87±1.40 before and after intervention in the A card test, respectively. The scores of the experimental group before and after intervention were 97.65±1.27 and 99.70±0.46, respectively. In the detection of the B card, the scores of the control group before and after intervention were 94.75±1.77 and 95.18±2.22, respectively, while the detection scores of the experimental group were 95.10±1.66 and 98.73±1.04, respectively. In the C card, the scores of the control group before and after intervention were 87.20±3.83 and 88.08±3.76, respectively. The scores of the experimental group before and after intervention were 86.53±3.55 and 95.60±2.12, respectively. From the data results, it can be seen that the experimental group showed a greater increase in Stroop color word test scores after intervention, indicating that vocal training can effectively improve cognitive function in patients with schizophrenia. Discussion The experimental results indicate that the intervention method of vocal training can improve patients’ thinking expression ability and memory by soothing their physical and mental health, and through vocal music. Through vocal training, patients with schizophrenia can enhance their self-identity through beautiful musical works and singing behavior, thereby improving their psychological state and cognitive function, enhancing their self-management level and quality of life.","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":"51 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-18DOI: 10.1093/schbul/sbaf007.019
Yang Meng*, Xilan Wang, Hongyan Lu
Background Schizophrenia is a chronic mental illness characterized by cognitive, affective, and behavioral disorders, and its patients often exhibit impaired social functioning. In traditional Chinese culture, family training has an important influence on shaping personal behavior, and schizophrenia patients who are influenced by traditional family training culture may need additional patient behavior modification during treatment. Paliperidone, as a new antipsychotic drug, has attracted much attention for its significant therapeutic effect on patients with schizophrenia. This study explores the efficacy of behavior modification in patients with schizophrenia under the intervention of paliperidone treatment combined with traditional family training and cultural background intervention. Methods The study recruited 80 patients with schizophrenia, of whom 40 were exposed to traditional family training culture as the experimental group, and the remaining 40 were not exposed to traditional family training culture as the control group. All patients met the diagnostic criteria for schizophrenia in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). All patients signed informed consent. The study used the Positive and Negative Syndrome Scale (PANSS), the Social Disability Screening Schedule (SDSS) and the Behavioral Adaptation Scale (BAS) to evaluate the treatment effect of patients, and recorded the scale scores of different treatment cycles. Results The study compared and analyzed the BAS scale evaluation results of the two groups of patients and compared the scores of patients at different treatment times as shown in Table 1. As can be seen from Table 1, there are differences in the scores of schizophrenia patients under different treatment cycles, with the experimental group having the highest scale score. After 12 weeks of treatment, the scale score of the experimental group reached 49.2±4.2, and the scale score of the control group reached 42.7±4.8. There was a statistically significant difference between the scale scores of the two groups of patients (P<0.05). Except for no treatment, there were significant statistical differences in the scale scores of the two groups of patients during the other treatment cycles (P<0.05). It can be seen that through paliperidone treatment combined with family training and cultural intervention, the patient has significant therapeutic effects in behavioral modification treatment. Discussion The results of the study showed that traditional family education combined with paliperidone treatment can effectively improve the behavioral adaptability of patients with schizophrenia, especially for some patients who are deeply influenced by traditional culture. However, the intervention treatment plan for different patients’ education and family background needs to be further improved. The study aims to provide more valuable references for the practical application of drug combined with cultural
{"title":"19 BEHAVIOR MODIFICATION IN SCHIZOPHRENIC PATIENTS WITH TRADITIONAL FAMILY CULTURE TREATED WITH PALIPERIDONE","authors":"Yang Meng*, Xilan Wang, Hongyan Lu","doi":"10.1093/schbul/sbaf007.019","DOIUrl":"https://doi.org/10.1093/schbul/sbaf007.019","url":null,"abstract":"Background Schizophrenia is a chronic mental illness characterized by cognitive, affective, and behavioral disorders, and its patients often exhibit impaired social functioning. In traditional Chinese culture, family training has an important influence on shaping personal behavior, and schizophrenia patients who are influenced by traditional family training culture may need additional patient behavior modification during treatment. Paliperidone, as a new antipsychotic drug, has attracted much attention for its significant therapeutic effect on patients with schizophrenia. This study explores the efficacy of behavior modification in patients with schizophrenia under the intervention of paliperidone treatment combined with traditional family training and cultural background intervention. Methods The study recruited 80 patients with schizophrenia, of whom 40 were exposed to traditional family training culture as the experimental group, and the remaining 40 were not exposed to traditional family training culture as the control group. All patients met the diagnostic criteria for schizophrenia in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). All patients signed informed consent. The study used the Positive and Negative Syndrome Scale (PANSS), the Social Disability Screening Schedule (SDSS) and the Behavioral Adaptation Scale (BAS) to evaluate the treatment effect of patients, and recorded the scale scores of different treatment cycles. Results The study compared and analyzed the BAS scale evaluation results of the two groups of patients and compared the scores of patients at different treatment times as shown in Table 1. As can be seen from Table 1, there are differences in the scores of schizophrenia patients under different treatment cycles, with the experimental group having the highest scale score. After 12 weeks of treatment, the scale score of the experimental group reached 49.2±4.2, and the scale score of the control group reached 42.7±4.8. There was a statistically significant difference between the scale scores of the two groups of patients (P&lt;0.05). Except for no treatment, there were significant statistical differences in the scale scores of the two groups of patients during the other treatment cycles (P&lt;0.05). It can be seen that through paliperidone treatment combined with family training and cultural intervention, the patient has significant therapeutic effects in behavioral modification treatment. Discussion The results of the study showed that traditional family education combined with paliperidone treatment can effectively improve the behavioral adaptability of patients with schizophrenia, especially for some patients who are deeply influenced by traditional culture. However, the intervention treatment plan for different patients’ education and family background needs to be further improved. The study aims to provide more valuable references for the practical application of drug combined with cultural","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":"64 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-18DOI: 10.1093/schbul/sbaf007.084
Xiaofen Wang, Fuxuan Liao, Zongfei Li, Lihua Han, Yanzhen Wang, Hang Li
Background Virtual Reality (VR) digital tourism refers to the use of VR technology combined with digitalization to create virtual experiences with cultural and tourism elements. Through VR technology, users can immerse themselves in exploring various cultural heritage, historical scenes, tourist attractions, etc., achieving cultural and tourism experiences in virtual spaces. With the continuous advancement of VR technology, it has also been widely applied in the field of mental illness. VR technology can bring patients into a virtual environment and provide them with immersive therapy, effectively alleviating their symptoms. The research aims to explore the moderating effect of VR digital tourism on psychological stress in patients with schizophrenia, in order to provide guidance for clinical practice. Methods 56 patients diagnosed with schizophrenia in the Department of Psychiatry from January 2024 to June 2024 were selected from the First People’s Hospital of a certain city. The participants were randomly assigned to a VR digital tourism treatment group (28 patients) and a conventional treatment group (28 patients). The conventional treatment group received treatment through medication and psychological guidance, while the VR digital tourism treatment group provided patients with VR devices and selected virtual environments based on their needs for treatment. The treatment lasted for 3 months. Using SPSS 22.0 statistical software for data analysis, the status of patients with schizophrenia was evaluated through the Schizophrenia Quality of Life Scale (SQLS), which includes three dimensions: psychosocial, energy dynamics, and symptoms/side effects. Results The comparison results of the included patients’ SQL scores are shown in Table 1. Before intervention, the VR digital tourism treatment group scored 32.25 ± 5.08, 20.46 ± 4.17, and 22.38 ± 4.74 in the dimensions of psychosocial, energy dynamics, and symptom/side effects, respectively. After intervention, the VR digital tourism treatment group scored 23.86 ± 2.82, 14.58 ± 2.12, and 15.52 ± 2.02 in three dimensions, respectively. After intervention, the scores of the VR digital tourism treatment group in three dimensions were lower than before intervention, and the scores of the VR digital tourism treatment group after intervention were significantly lower than those of the conventional treatment group, with a significant difference between the two groups (P<0.05). Discussion VR digital tourism has a significant effect on stress regulation in patients with schizophrenia. VR technology can help patients with schizophrenia relax their body and mind, enjoy their mood, improve their sleep quality, and effectively regulate their stress by creating numerous high-quality scenes. Funding 2022YFF0902402; 2024-01; 22285801Z; ZD202121; 22375801D.
{"title":"84 THE STRESS REGULATION OF PSYCHIATRIC PATIENTS THROUGH VR DIGITAL CULTURAL TOURISM","authors":"Xiaofen Wang, Fuxuan Liao, Zongfei Li, Lihua Han, Yanzhen Wang, Hang Li","doi":"10.1093/schbul/sbaf007.084","DOIUrl":"https://doi.org/10.1093/schbul/sbaf007.084","url":null,"abstract":"Background Virtual Reality (VR) digital tourism refers to the use of VR technology combined with digitalization to create virtual experiences with cultural and tourism elements. Through VR technology, users can immerse themselves in exploring various cultural heritage, historical scenes, tourist attractions, etc., achieving cultural and tourism experiences in virtual spaces. With the continuous advancement of VR technology, it has also been widely applied in the field of mental illness. VR technology can bring patients into a virtual environment and provide them with immersive therapy, effectively alleviating their symptoms. The research aims to explore the moderating effect of VR digital tourism on psychological stress in patients with schizophrenia, in order to provide guidance for clinical practice. Methods 56 patients diagnosed with schizophrenia in the Department of Psychiatry from January 2024 to June 2024 were selected from the First People’s Hospital of a certain city. The participants were randomly assigned to a VR digital tourism treatment group (28 patients) and a conventional treatment group (28 patients). The conventional treatment group received treatment through medication and psychological guidance, while the VR digital tourism treatment group provided patients with VR devices and selected virtual environments based on their needs for treatment. The treatment lasted for 3 months. Using SPSS 22.0 statistical software for data analysis, the status of patients with schizophrenia was evaluated through the Schizophrenia Quality of Life Scale (SQLS), which includes three dimensions: psychosocial, energy dynamics, and symptoms/side effects. Results The comparison results of the included patients’ SQL scores are shown in Table 1. Before intervention, the VR digital tourism treatment group scored 32.25 ± 5.08, 20.46 ± 4.17, and 22.38 ± 4.74 in the dimensions of psychosocial, energy dynamics, and symptom/side effects, respectively. After intervention, the VR digital tourism treatment group scored 23.86 ± 2.82, 14.58 ± 2.12, and 15.52 ± 2.02 in three dimensions, respectively. After intervention, the scores of the VR digital tourism treatment group in three dimensions were lower than before intervention, and the scores of the VR digital tourism treatment group after intervention were significantly lower than those of the conventional treatment group, with a significant difference between the two groups (P&lt;0.05). Discussion VR digital tourism has a significant effect on stress regulation in patients with schizophrenia. VR technology can help patients with schizophrenia relax their body and mind, enjoy their mood, improve their sleep quality, and effectively regulate their stress by creating numerous high-quality scenes. Funding 2022YFF0902402; 2024-01; 22285801Z; ZD202121; 22375801D.","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":"80 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-18DOI: 10.1093/schbul/sbaf007.003
Wen Zhang
Background At present, there are a large number of special groups of patients with schizophrenia in China, such as elderly patients with mental illness, adolescents with intellectual disabilities, and other patients. The causes and characteristics of this special group of patients pose many difficulties in treatment. Film therapy, as an emerging form of psychological therapy, may improve patients’ psychological states by allowing them to watch carefully selected movies that evoke emotional resonance and reflection. Movie therapy has a good improvement effect on conventional anxiety disorders and mental illnesses, and is safer and more effective than traditional medication. In order to treat a special group of schizophrenia patients, the study will explore the therapeutic effects of film therapy on patients and conduct related research. Methods In the study, 50 special group schizophrenia patients were selected as the experimental group, and another 50 age-matched general schizophrenia patients were selected as the control group. Among them, the experimental group will carry out a 12-week film therapy, watching movies 3 times a week, and having group discussions to share their feelings after each movie viewing. Both groups of personnel underwent evaluation of scale indicators, including the Positive and Negative Symptoms Scale (PANSS), with a total score of 30-210 points, with higher scores indicating more severe symptoms; Social Function Deficiency Screening Scale (SDSS): 0-2 points for no defects, 3-5 points for mild defects, 6-8 points for moderate defects, 9-12 points for severe defects; Insight and Treatment Attitude Questionnaire (ITAQ): 0-10 points for poor insight, 11-20 points for partial insight, 21-30 points for good insight; Mini Mental State Examination (MMSE): 0-17 points for severe cognitive impairment, 18-23 points for moderate cognitive impairment, 24-30 points for mild cognitive impairment or normal; Activities of Daily Living Scale (ADL): 20-80 points, the higher the score, the better the daily living ability. Results Table 1 shows the test results of different groups of scales. After undergoing movie therapy, the PANSS score of the experimental group significantly decreased, indicating that the patient’s symptoms had been alleviated; In addition, the SDSS score has decreased and social functional deficits have been improved, there is a statistically significant difference (P<0.05) when compared before and after. Meanwhile, the various indicators of the experimental group patients gradually approached those of the control group, indicating that film therapy is effective in treating patients. Discussion According to the experimental results, movie therapy has a positive effect on special groups of schizophrenia patients, and various social function indicators gradually approach the normal group. The main reason may be related to the artistic atmosphere of movies, which can expose patients to rich emotional and social situa
{"title":"3 RESEARCH ON THE EFFECT OF MOVIE THERAPY AND IMPROVEMENT OF SOCIAL FUNCTION IN SPECIAL GROUPS OF SCHIZOPHRENIA PATIENTS","authors":"Wen Zhang","doi":"10.1093/schbul/sbaf007.003","DOIUrl":"https://doi.org/10.1093/schbul/sbaf007.003","url":null,"abstract":"Background At present, there are a large number of special groups of patients with schizophrenia in China, such as elderly patients with mental illness, adolescents with intellectual disabilities, and other patients. The causes and characteristics of this special group of patients pose many difficulties in treatment. Film therapy, as an emerging form of psychological therapy, may improve patients’ psychological states by allowing them to watch carefully selected movies that evoke emotional resonance and reflection. Movie therapy has a good improvement effect on conventional anxiety disorders and mental illnesses, and is safer and more effective than traditional medication. In order to treat a special group of schizophrenia patients, the study will explore the therapeutic effects of film therapy on patients and conduct related research. Methods In the study, 50 special group schizophrenia patients were selected as the experimental group, and another 50 age-matched general schizophrenia patients were selected as the control group. Among them, the experimental group will carry out a 12-week film therapy, watching movies 3 times a week, and having group discussions to share their feelings after each movie viewing. Both groups of personnel underwent evaluation of scale indicators, including the Positive and Negative Symptoms Scale (PANSS), with a total score of 30-210 points, with higher scores indicating more severe symptoms; Social Function Deficiency Screening Scale (SDSS): 0-2 points for no defects, 3-5 points for mild defects, 6-8 points for moderate defects, 9-12 points for severe defects; Insight and Treatment Attitude Questionnaire (ITAQ): 0-10 points for poor insight, 11-20 points for partial insight, 21-30 points for good insight; Mini Mental State Examination (MMSE): 0-17 points for severe cognitive impairment, 18-23 points for moderate cognitive impairment, 24-30 points for mild cognitive impairment or normal; Activities of Daily Living Scale (ADL): 20-80 points, the higher the score, the better the daily living ability. Results Table 1 shows the test results of different groups of scales. After undergoing movie therapy, the PANSS score of the experimental group significantly decreased, indicating that the patient’s symptoms had been alleviated; In addition, the SDSS score has decreased and social functional deficits have been improved, there is a statistically significant difference (P&lt;0.05) when compared before and after. Meanwhile, the various indicators of the experimental group patients gradually approached those of the control group, indicating that film therapy is effective in treating patients. Discussion According to the experimental results, movie therapy has a positive effect on special groups of schizophrenia patients, and various social function indicators gradually approach the normal group. The main reason may be related to the artistic atmosphere of movies, which can expose patients to rich emotional and social situa","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":"49 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-18DOI: 10.1093/schbul/sbaf007.005
Deng Liu
Background Through multi-sensory interaction, tourism healing can generate positive emotions, broaden cognitive ability, and improve social relations, thus promoting healthy behaviors. In recent years, olanzapine and risperidone, as atypical antipsychotic drugs, have been proved to have better efficacy and lower incidence of adverse reactions in the treatment of schizophrenia. And they have a significant improvement in patients’ clinical symptoms and cognitive function. Tourism therapy can be used as a multi-dimensional treatment, which may have a synergistic effect when combined with drug therapy. Therefore, the study carried out the treatment on the basis of the above atypical antipsychotic medication combined with tourism therapy. Methods Sixty schizophrenic patients admitted to Guihang Sang03 Hospital of AVIC from January 2022 to March 2023 were selected as the observation group, and healthy volunteers with similar general data were selected as the control group. The observation group was divided into long DUP subgroup and short DUP subgroup according to the duration of untreated psychosis (DUP). The control group was treated with the atypical antipsychotic drug risperidone: the initial dose of treatment was 1mg twice daily. During the first 7 days of treatment, the drug dose is gradually increased to 3mg/ day twice daily. After 14 days, the drug dose should be increased according to the development of the patient’s disease, but it should be controlled in the range of 4 to 6mg/ day. The entire treatment cycle lasted 56 days. The observation group was given tourism therapy on the basis of the control group: the patients were allowed to choose a destination suitable for their relaxation and participate in some activities that can relax the body and mind, such as yoga, mountaineering, etc. Make new friends while traveling and share your experiences and feelings with each other. The serum Homocysteine (Hcy) level was observed before and after 2 months of treatment. Results Before treatment, the Hcy level in observation group was 26.29±7.03μmol/L, which was significantly higher than that in control group (114.23±2.87μmol/L) (P < 0.05). The average level of Hcy in the long DUP subgroup was 29.02±7.07μmol/L, which was also significantly higher than that in the short DUP subgroup (24.12±6.34μmol/L), and the differences were statistically significant (P < 0.05). After treatment, the mean Hcy level in the long DUP subgroup was reduced to 14.74±2.81μmol/L, and that in the short DUP subgroup was reduced to 12.88±1.68μmol/L, and the Hcy level in both groups was significantly decreased (P < 0.05). However, even after treatment, the mean Hcy level in the long DUP subgroup was still higher than that in the short DUP subgroup, and the difference was still statistically significant (P < 0.05). Discussion This study compared the difference of serum Hcy level and cognitive function between schizophrenic patients and normal controls. T
{"title":"5 THE TREATMENT OF SCHIZOPHRENIA WITH THE ADDITION OF ATYPICAL ANTIPSYCHOTIC MEDICATION TO TRAVEL THERAPY","authors":"Deng Liu","doi":"10.1093/schbul/sbaf007.005","DOIUrl":"https://doi.org/10.1093/schbul/sbaf007.005","url":null,"abstract":"Background Through multi-sensory interaction, tourism healing can generate positive emotions, broaden cognitive ability, and improve social relations, thus promoting healthy behaviors. In recent years, olanzapine and risperidone, as atypical antipsychotic drugs, have been proved to have better efficacy and lower incidence of adverse reactions in the treatment of schizophrenia. And they have a significant improvement in patients’ clinical symptoms and cognitive function. Tourism therapy can be used as a multi-dimensional treatment, which may have a synergistic effect when combined with drug therapy. Therefore, the study carried out the treatment on the basis of the above atypical antipsychotic medication combined with tourism therapy. Methods Sixty schizophrenic patients admitted to Guihang Sang03 Hospital of AVIC from January 2022 to March 2023 were selected as the observation group, and healthy volunteers with similar general data were selected as the control group. The observation group was divided into long DUP subgroup and short DUP subgroup according to the duration of untreated psychosis (DUP). The control group was treated with the atypical antipsychotic drug risperidone: the initial dose of treatment was 1mg twice daily. During the first 7 days of treatment, the drug dose is gradually increased to 3mg/ day twice daily. After 14 days, the drug dose should be increased according to the development of the patient’s disease, but it should be controlled in the range of 4 to 6mg/ day. The entire treatment cycle lasted 56 days. The observation group was given tourism therapy on the basis of the control group: the patients were allowed to choose a destination suitable for their relaxation and participate in some activities that can relax the body and mind, such as yoga, mountaineering, etc. Make new friends while traveling and share your experiences and feelings with each other. The serum Homocysteine (Hcy) level was observed before and after 2 months of treatment. Results Before treatment, the Hcy level in observation group was 26.29±7.03μmol/L, which was significantly higher than that in control group (114.23±2.87μmol/L) (P &lt; 0.05). The average level of Hcy in the long DUP subgroup was 29.02±7.07μmol/L, which was also significantly higher than that in the short DUP subgroup (24.12±6.34μmol/L), and the differences were statistically significant (P &lt; 0.05). After treatment, the mean Hcy level in the long DUP subgroup was reduced to 14.74±2.81μmol/L, and that in the short DUP subgroup was reduced to 12.88±1.68μmol/L, and the Hcy level in both groups was significantly decreased (P &lt; 0.05). However, even after treatment, the mean Hcy level in the long DUP subgroup was still higher than that in the short DUP subgroup, and the difference was still statistically significant (P &lt; 0.05). Discussion This study compared the difference of serum Hcy level and cognitive function between schizophrenic patients and normal controls. T","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":"99 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-18DOI: 10.1093/schbul/sbaf007.029
Yuan Cheng
Background Schizophrenia is a complex and severe mental disorder that typically manifests in late adolescence or early adulthood. Its characteristics include abnormalities in thinking, emotions, and behavior, which have long-term adverse effects on the patient’s cognitive and social functioning. Cognitive impairment is one of the important features of schizophrenia, especially in patients with first onset schizophrenia (FES), where this impairment may be more pronounced and directly affect the treatment effectiveness and quality of life of the disease. Vocational college students, as a special group, may experience cognitive impairment due to their educational environment and psychological pressure. Early intervention in FES patients is key to improving long-term prognosis, therefore, in-depth research on the risk factors of cognitive impairment in this population is of great significance for optimizing intervention measures. Methods The study focuses on FES patients in vocational colleges and systematically analyzes the main risk factors for cognitive impairment, providing scientific basis for intervention strategies in this field. The study was designed as a cross-sectional study, recruiting a total of 150 first-episode schizophrenia patients from vocational colleges. Evaluate the overall cognitive function of patients using the Montreal Cognitive Assessment Scale (MoCA), while selecting neuropsychological domains such as memory, executive function, and attention for in-depth analysis. The socio demographic characteristics, disease history, and psychosocial factors of patients were obtained through standardized questionnaires and structured interviews. Using univariate analysis to screen potential variables associated with cognitive impairment, and further determining significant independent risk factors through multivariate logistic regression analysis. Results The analysis of the situation of each patient is shown in Table 1. According to Table 1, among 150 patients, 92 (61.3%) had significant cognitive impairment (MoCA score<26). Multivariate logistic regression analysis showed that the following risk factors were significantly associated with cognitive impairment. Untreated duration of mental illness exceeding 12 months significantly increases the risk of cognitive impairment, and patients with lower levels of education have poorer cognitive function. Patients with higher scores on the Negative Symptom Assessment Scale have a significantly increased risk of cognitive impairment. Discussion The research results indicate that the incidence of cognitive impairment is higher in first-episode schizophrenia patients in vocational colleges, and the main risk factors include longer duration of untreated mental illness, lower education level, and severe negative symptoms. Early intervention should focus on shortening treatment delays, strengthening educational support, and actively treating negative symptoms to alleviate cognitive impairment
{"title":"29 THE RISK FACTOR ANALYSIS OF COGNITIVE IMPAIRMENT IN PATIENTS WITH FIRST-EPISODE SCHIZOPHRENIA IN VOCATIONAL COLLEGES AND UNIVERSITIES","authors":"Yuan Cheng","doi":"10.1093/schbul/sbaf007.029","DOIUrl":"https://doi.org/10.1093/schbul/sbaf007.029","url":null,"abstract":"Background Schizophrenia is a complex and severe mental disorder that typically manifests in late adolescence or early adulthood. Its characteristics include abnormalities in thinking, emotions, and behavior, which have long-term adverse effects on the patient’s cognitive and social functioning. Cognitive impairment is one of the important features of schizophrenia, especially in patients with first onset schizophrenia (FES), where this impairment may be more pronounced and directly affect the treatment effectiveness and quality of life of the disease. Vocational college students, as a special group, may experience cognitive impairment due to their educational environment and psychological pressure. Early intervention in FES patients is key to improving long-term prognosis, therefore, in-depth research on the risk factors of cognitive impairment in this population is of great significance for optimizing intervention measures. Methods The study focuses on FES patients in vocational colleges and systematically analyzes the main risk factors for cognitive impairment, providing scientific basis for intervention strategies in this field. The study was designed as a cross-sectional study, recruiting a total of 150 first-episode schizophrenia patients from vocational colleges. Evaluate the overall cognitive function of patients using the Montreal Cognitive Assessment Scale (MoCA), while selecting neuropsychological domains such as memory, executive function, and attention for in-depth analysis. The socio demographic characteristics, disease history, and psychosocial factors of patients were obtained through standardized questionnaires and structured interviews. Using univariate analysis to screen potential variables associated with cognitive impairment, and further determining significant independent risk factors through multivariate logistic regression analysis. Results The analysis of the situation of each patient is shown in Table 1. According to Table 1, among 150 patients, 92 (61.3%) had significant cognitive impairment (MoCA score&lt;26). Multivariate logistic regression analysis showed that the following risk factors were significantly associated with cognitive impairment. Untreated duration of mental illness exceeding 12 months significantly increases the risk of cognitive impairment, and patients with lower levels of education have poorer cognitive function. Patients with higher scores on the Negative Symptom Assessment Scale have a significantly increased risk of cognitive impairment. Discussion The research results indicate that the incidence of cognitive impairment is higher in first-episode schizophrenia patients in vocational colleges, and the main risk factors include longer duration of untreated mental illness, lower education level, and severe negative symptoms. Early intervention should focus on shortening treatment delays, strengthening educational support, and actively treating negative symptoms to alleviate cognitive impairment ","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":"6 1 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-18DOI: 10.1093/schbul/sbaf007.035
Zheng Wu
Background Schizophrenia, as a mental and psychological disorder of early-onset dementia, is mainly manifested in cognitive deviation, social sensitivity, and hallucinations in adolescents, which in turn affects their learning, life, and social interactions. At present, the treatment plan for student schizophrenia mainly adopts antipsychotic drugs and psychological counseling, which have a good control effect on hospitalized patients. Research on utilizing the role of vocational college teachers in early intervention for students with schizophrenia to assist in the treatment of their mental and psychological disorders. Methods Firstly, 100 vocational college students who meet the criteria for early symptoms of schizophrenia will be evaluated by professional physicians and confirmed to have no other mental disorders. Next, 100 students will be randomly selected and divided into a control group of 50 and an experimental group of 50. Both groups received routine nursing interventions, while students in the experimental group received psychological counseling and role intervention from teachers on this basis. They provided disease explanations and actively communicated with patients to maintain their dignity and reduce their sense of shame. Finally, before and after the treatment intervention, the two groups of patients were evaluated using the Feelings of Inadequacy Scale (FIS), Medical Coping Modes Questionnaire (MCMQ), and Generic Quality of Life Inventory (GQOLI-74), and statistical significance was analyzed using SPSS 25.0 software. Results There was no statistically significant difference in FIS evaluation between the two groups before intervention (P>0.05). After the intervention, the FIS score of the experimental group improved, with a score of 26.36 ± 3.68 for FIS self-esteem, which was about 49% higher than before the intervention. There was a significant difference (P<0.001) in the scoring results compared to the control group, indicating that the auxiliary intervention of vocational college teachers has an effective relief and positive effect on students with schizophrenia. The results are shown in Table 1. Discussion Research on adding teacher role communication intervention on the basis of routine nursing intervention to enhance the effectiveness of teachers in influencing students’ mental health. The results showed that routine nursing interventions can improve the psychological problems of early schizophrenia students to a certain extent, but combined with communication and positive guidance from vocational college teachers, students’ confidence in fighting schizophrenia was significantly enhanced, and the early intervention effect of schizophrenia was significantly improved.
{"title":"35 THE ROLE AND EFFECTIVENESS OF VOCATIONAL COLLEGE TEACHERS IN EARLY INTERVENTION FOR STUDENTS WITH SCHIZOPHRENIA","authors":"Zheng Wu","doi":"10.1093/schbul/sbaf007.035","DOIUrl":"https://doi.org/10.1093/schbul/sbaf007.035","url":null,"abstract":"Background Schizophrenia, as a mental and psychological disorder of early-onset dementia, is mainly manifested in cognitive deviation, social sensitivity, and hallucinations in adolescents, which in turn affects their learning, life, and social interactions. At present, the treatment plan for student schizophrenia mainly adopts antipsychotic drugs and psychological counseling, which have a good control effect on hospitalized patients. Research on utilizing the role of vocational college teachers in early intervention for students with schizophrenia to assist in the treatment of their mental and psychological disorders. Methods Firstly, 100 vocational college students who meet the criteria for early symptoms of schizophrenia will be evaluated by professional physicians and confirmed to have no other mental disorders. Next, 100 students will be randomly selected and divided into a control group of 50 and an experimental group of 50. Both groups received routine nursing interventions, while students in the experimental group received psychological counseling and role intervention from teachers on this basis. They provided disease explanations and actively communicated with patients to maintain their dignity and reduce their sense of shame. Finally, before and after the treatment intervention, the two groups of patients were evaluated using the Feelings of Inadequacy Scale (FIS), Medical Coping Modes Questionnaire (MCMQ), and Generic Quality of Life Inventory (GQOLI-74), and statistical significance was analyzed using SPSS 25.0 software. Results There was no statistically significant difference in FIS evaluation between the two groups before intervention (P&gt;0.05). After the intervention, the FIS score of the experimental group improved, with a score of 26.36 ± 3.68 for FIS self-esteem, which was about 49% higher than before the intervention. There was a significant difference (P&lt;0.001) in the scoring results compared to the control group, indicating that the auxiliary intervention of vocational college teachers has an effective relief and positive effect on students with schizophrenia. The results are shown in Table 1. Discussion Research on adding teacher role communication intervention on the basis of routine nursing intervention to enhance the effectiveness of teachers in influencing students’ mental health. The results showed that routine nursing interventions can improve the psychological problems of early schizophrenia students to a certain extent, but combined with communication and positive guidance from vocational college teachers, students’ confidence in fighting schizophrenia was significantly enhanced, and the early intervention effect of schizophrenia was significantly improved.","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":"6 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background With the aging of the population, the number of elderly patients with schizophrenia is increasing year by year. These patients not only face mental health problems, but also face increased physical and psychological burdens due to the uncomfortable aging of their living environment. Studies show that an aging-appropriate design can improve quality of life and mental health in older adults, but there is a relative lack of research on its impact on symptoms in older adults with schizophrenia. Aging-appropriate design includes accessible access, adequate lighting, safety handrails, etc. These design elements may have a positive impact on the daily life and symptom management of elderly patients with schizophrenia. The study aims to explore whether the aging-appropriate design of residential buildings in the elderly can reduce the symptoms of elderly people with schizophrenia, improve their quality of life, and provide theoretical basis and practical guidance for future architectural design. Methods The study selected 300 elderly patients with schizophrenia over 60 years old, all of whom lived in buildings with different aging degrees. A randomized controlled trial will randomize participants into two groups: aging design and traditional design. The buildings of the aging design group were renovated, including barrier-free access, adequate lighting and safety handrails, while the buildings of the traditional design group were kept as is. The duration of the study was 12 months, during which participants were collected through an electronic health record system, including delusions, delusions, social withdrawal, etc. In addition, participants symptoms were quantified using the Schizophrenia Symptom Scale (SAPS) and the Positive and Negative Symptom Scale (PANSS). Results Data analysis showed that the SAPS and PANSS scores in the aging design group were significantly lower during the 12 months compared with the control group. Specifically, the SAPS score decline averaged 2.5 points (P=0.01) and PANSS scores decreased by 3.0 points (P=0.02). In addition, social withdrawal behavior in the aging design group was decreased by 30% (P=0.03) and 25% (P=0.04) and 20% (P=0.05), respectively. These results suggest that an aging-appropriate design may have a positive effect on reducing symptoms in older adults with schizophrenia. Discussion The results of the study indicate that age-appropriate design has a significant positive impact on symptom management in elderly patients with schizophrenia. Improving the safety and comfort of the living environment may help patients reduce anxiety and fear, thereby alleviating symptoms. These findings are important for the design of buildings for the elderly, indicating the need to consider the needs of elderly patients with schizophrenia when designing. Aging friendly design improves patients’ quality of life and may reduce the use of medical resources. Future research can further explore the specific impact of d
{"title":"108 THE IMPACT OF AGING FRIENDLY DESIGN OF RESIDENTIAL BUILDINGS FOR THE ELDERLY ON THE SYMPTOMS OF ELDERLY PATIENTS WITH SCHIZOPHRENIA","authors":"Biyao Zhou, Zhongwei Shen*, Jiawei Li, Yangguang Hao","doi":"10.1093/schbul/sbaf007.108","DOIUrl":"https://doi.org/10.1093/schbul/sbaf007.108","url":null,"abstract":"Background With the aging of the population, the number of elderly patients with schizophrenia is increasing year by year. These patients not only face mental health problems, but also face increased physical and psychological burdens due to the uncomfortable aging of their living environment. Studies show that an aging-appropriate design can improve quality of life and mental health in older adults, but there is a relative lack of research on its impact on symptoms in older adults with schizophrenia. Aging-appropriate design includes accessible access, adequate lighting, safety handrails, etc. These design elements may have a positive impact on the daily life and symptom management of elderly patients with schizophrenia. The study aims to explore whether the aging-appropriate design of residential buildings in the elderly can reduce the symptoms of elderly people with schizophrenia, improve their quality of life, and provide theoretical basis and practical guidance for future architectural design. Methods The study selected 300 elderly patients with schizophrenia over 60 years old, all of whom lived in buildings with different aging degrees. A randomized controlled trial will randomize participants into two groups: aging design and traditional design. The buildings of the aging design group were renovated, including barrier-free access, adequate lighting and safety handrails, while the buildings of the traditional design group were kept as is. The duration of the study was 12 months, during which participants were collected through an electronic health record system, including delusions, delusions, social withdrawal, etc. In addition, participants symptoms were quantified using the Schizophrenia Symptom Scale (SAPS) and the Positive and Negative Symptom Scale (PANSS). Results Data analysis showed that the SAPS and PANSS scores in the aging design group were significantly lower during the 12 months compared with the control group. Specifically, the SAPS score decline averaged 2.5 points (P=0.01) and PANSS scores decreased by 3.0 points (P=0.02). In addition, social withdrawal behavior in the aging design group was decreased by 30% (P=0.03) and 25% (P=0.04) and 20% (P=0.05), respectively. These results suggest that an aging-appropriate design may have a positive effect on reducing symptoms in older adults with schizophrenia. Discussion The results of the study indicate that age-appropriate design has a significant positive impact on symptom management in elderly patients with schizophrenia. Improving the safety and comfort of the living environment may help patients reduce anxiety and fear, thereby alleviating symptoms. These findings are important for the design of buildings for the elderly, indicating the need to consider the needs of elderly patients with schizophrenia when designing. Aging friendly design improves patients’ quality of life and may reduce the use of medical resources. Future research can further explore the specific impact of d","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":"24 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-18DOI: 10.1093/schbul/sbaf007.001
Xu Li*, Jing Cao
Background Schizophrenia is a serious mental disorder, and patients often have significant differences from ordinary people in perception, thinking, emotions, and behavior. At present, impaired facial emotion recognition ability is one of the common symptoms of schizophrenia patients. Schizophrenia patients have difficulty accurately recognizing the emotional information conveyed by others’ facial expressions, which has a negative impact on their life and learning. In recent years, with the continuous development of visual technology, it has corresponding applications in the treatment of schizophrenia patients. It can use facial emotion recognition to help patients train their emotional perception ability and play a certain role in the treatment of patients’ social function. Therefore, in order to improve the symptoms of schizophrenia patients, a facial emotion recognition interactive system specifically designed for schizophrenia patients is studied and designed, and its application effect in the treatment of schizophrenia patients is analyzed. Methods In the study, 30 patients with schizophrenia were selected, aged between 20 and 50 years old. At the same time, 30 healthy volunteers matched in age, gender, and experimental group were selected as the control group group for the study. Among them, both the experimental group and the control group underwent a basic psychological assessment first, including emotions, sleep status, learning ability, self harm tendency, anxiety, inferiority complex, appetite, relaxation, and other aspects. Specific experimental process: The experimental group used a facial emotion recognition interactive system for 8 weeks of training, 5 times a week, with each session lasting 30 minutes. The system displays images and videos of different facial expressions for patients to recognize and provide feedback, while also providing correct answer prompts and emotional interpretation guidance. The control group engaged in regular daily activities at the same time without any other interventions. After 8 weeks of the experiment, both groups underwent the same psychological evaluation again, there was a statistically significant difference before and after (P<0.05). Results Table 1 shows the results of two experimental tests. After training with a facial emotion recognition interactive system, the experimental group showed significant improvements in emotion recognition, sleep status, self harm tendency, anxiety, inferiority complex, appetite, and relaxation, and all indicators gradually approached the normal level of the control group. Discussion The experimental results indicate that the facial emotion recognition interactive system for patients with schizophrenia has significant therapeutic effects. Through training, patients have significantly improved their facial emotion recognition ability, which has a positive impact on improving their psychological and social abilities. After the experiment, the experimental gr
{"title":"1 DESIGN OF FACIAL EMOTION RECOGNITION INTERACTIVE SYSTEM FOR SCHIZOPHRENIA PATIENTS","authors":"Xu Li*, Jing Cao","doi":"10.1093/schbul/sbaf007.001","DOIUrl":"https://doi.org/10.1093/schbul/sbaf007.001","url":null,"abstract":"Background Schizophrenia is a serious mental disorder, and patients often have significant differences from ordinary people in perception, thinking, emotions, and behavior. At present, impaired facial emotion recognition ability is one of the common symptoms of schizophrenia patients. Schizophrenia patients have difficulty accurately recognizing the emotional information conveyed by others’ facial expressions, which has a negative impact on their life and learning. In recent years, with the continuous development of visual technology, it has corresponding applications in the treatment of schizophrenia patients. It can use facial emotion recognition to help patients train their emotional perception ability and play a certain role in the treatment of patients’ social function. Therefore, in order to improve the symptoms of schizophrenia patients, a facial emotion recognition interactive system specifically designed for schizophrenia patients is studied and designed, and its application effect in the treatment of schizophrenia patients is analyzed. Methods In the study, 30 patients with schizophrenia were selected, aged between 20 and 50 years old. At the same time, 30 healthy volunteers matched in age, gender, and experimental group were selected as the control group group for the study. Among them, both the experimental group and the control group underwent a basic psychological assessment first, including emotions, sleep status, learning ability, self harm tendency, anxiety, inferiority complex, appetite, relaxation, and other aspects. Specific experimental process: The experimental group used a facial emotion recognition interactive system for 8 weeks of training, 5 times a week, with each session lasting 30 minutes. The system displays images and videos of different facial expressions for patients to recognize and provide feedback, while also providing correct answer prompts and emotional interpretation guidance. The control group engaged in regular daily activities at the same time without any other interventions. After 8 weeks of the experiment, both groups underwent the same psychological evaluation again, there was a statistically significant difference before and after (P&lt;0.05). Results Table 1 shows the results of two experimental tests. After training with a facial emotion recognition interactive system, the experimental group showed significant improvements in emotion recognition, sleep status, self harm tendency, anxiety, inferiority complex, appetite, and relaxation, and all indicators gradually approached the normal level of the control group. Discussion The experimental results indicate that the facial emotion recognition interactive system for patients with schizophrenia has significant therapeutic effects. Through training, patients have significantly improved their facial emotion recognition ability, which has a positive impact on improving their psychological and social abilities. After the experiment, the experimental gr","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":"80 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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