Schizophrenia Bulletin最新文献

{"title":"149. A study on the intrinsic link between \"social alienation\" in the modernization process and symptoms of schizophrenia","authors":"Tingyun Zhang","doi":"10.1093/schbul/sbag003.148","DOIUrl":"https://doi.org/10.1093/schbul/sbag003.148","url":null,"abstract":"Background Intensified social competition, weakened community support, and emotional alienation within families during modernization have placed significant long-term social pressure on individuals at high risk of schizophrenia. Surveys show that approximately 34% of individuals at high risk of schizophrenia are chronically socially isolated, and over 40% report a marked lack of social meaning. The combination of lack of social connection and alienation experiences, coupled with rapid changes in the urban environment, further increases the risk of worsening mental health symptoms. Early identification of potential high-risk individuals and monitoring of alienation-related indicators can facilitate precise intervention and reduce the incidence of psychosis conversion. Therefore, this study explores the intrinsic link between social alienation experiences and the development of schizophrenia symptoms under modernization through quantitative social alienation scoring and follow-up data, and evaluates its indicator value in risk prediction and clinical assessment. Methods This study included 300 individuals at high risk for schizophrenia (UHR), divided into an experimental group (n = 150) receiving high-risk screening for social alienation and targeted social reconnection intervention, and a control group (n = 150) receiving routine follow-up monitoring. Screening indicators included the Social Alienation Scale (SAS, cutoff score ≥ 65) and the Negative Symptom Scale (NSS). The intervention program for the experimental group included weekly social engagement training and bi-weekly group supportive psychological counseling for 12 weeks. The control group received only routine psychological interviews. All participants completed assessments at baseline (T0), mid-intervention (T1, 6 weeks), and end of intervention (T2), and the effect size Cohen's d was used to quantify the magnitude of change. The significance level was set at p<.05. Results At the end of the intervention (T2), the total SAS score of high-risk individuals in the experimental group significantly decreased from 72.6 ± 7.4 at T0 to 61.2 ± 6.8 (p<.001, d = 1.61), and the NSS score decreased from 21.3 ± 4.2 to 15.7 ± 3.8 (p<.001, d = 1.36). In contrast, the control group showed no significant changes in either indicator at T2 (p>.05). Intergroup comparisons showed that the experimental group was significantly better than the control group in terms of social connection restoration and symptom improvement (p<.01). Furthermore, the proportion of high-risk individuals in the experimental group who developed psychotic events at T2 was significantly lower than that in the control group (7.3% vs 18.0%, p=.012). Discussion Early intervention based on social reconnection screening can effectively alleviate negative symptoms, improve social functioning, and reduce the risk of psychosis conversion, demonstrating significant application value. The results suggest that ","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":"299 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146169546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"281. The effect of opera vocal therapy on chronic schizophrenia patients","authors":"Wenhui Ye","doi":"10.1093/schbul/sbag003.279","DOIUrl":"https://doi.org/10.1093/schbul/sbag003.279","url":null,"abstract":"Background Opera vocal music, as a comprehensive art form that integrates music, language, and emotional expression, has been proven to regulate emotional central activity and enhance social motivation. Its application in the rehabilitation of mental disorders is gradually receiving attention. However, the long-term impact of opera vocal music on the social functioning and quality of life of chronic patients is not yet clear. Therefore, the study aims to explore the improvement effect of opera vocal therapy on the severity of symptoms, social function, and quality of life in patients with chronic schizophrenia. And analyze its potential therapeutic mechanisms, providing new intervention ideas for the comprehensive rehabilitation of chronic schizophrenia. Methods Select 186 patients who meet the diagnostic criteria for chronic schizophrenia in the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition), including 102 males and 84 females. Simultaneously select 93 healthy volunteers matched in age and education level to construct a health group. Patients were randomly divided into an experimental group (n = 93) and a control group (n = 93). The control group received conventional medication treatment and standardized rehabilitation training, while the experimental group received opera vocal therapy in addition to the intervention of the control group, twice a week for 90 minutes each time, for 24 weeks. The content of opera vocal therapy includes basic vocal training (breathing control, pitch adjustment), opera segment singing, group choir, and role-playing. The Positive and Negative Syndrome Scale (PANSS) was used for evaluation at baseline and 24 weeks of treatment. Results The results are shown in Table 1. At baseline, there was no statistically significant difference in the total PANSS score between the experimental group and the control group (p=.621), indicating a good match between the two groups in terms of symptom severity. And the total PANSS scores of both groups of patients were significantly higher than those of the healthy control group (p<.001). After treatment, the total score of PANSS in the experimental group was significantly lower than that in the control group (p<.001), indicating a significant effect. Discussion Long term, structured opera vocal intervention can not only effectively alleviate the core mental symptoms of chronic schizophrenia, but may also have a positive impact on residual symptoms of poor drug treatment response. It also suggests that this form of art therapy has potential advantages in promoting emotional regulation and enhancing social participation motivation. Although there is still a significant difference in symptom levels between patients and healthy individuals after treatment, the significant improvement brought about by intervention provides new evidence-based support for improving the long-term functional decline and quality of life of patients with chronic schizophrenia","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":"38 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146169547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"207. Design and effectiveness verification of elderly social human-computer interaction system based on positive psychology","authors":"Yue Zhang","doi":"10.1093/schbul/sbag003.205","DOIUrl":"https://doi.org/10.1093/schbul/sbag003.205","url":null,"abstract":"Background In clinical practice of psychiatry, elderly individuals often experience significant psychological stress due to social isolation, and in severe cases, it can also trigger delayed onset mental disorders. Previous studies have mainly improved symptoms through medication and cognitive interventions, but research on enhancing positive emotional and social functioning in the elderly has shown that a single medical approach is difficult to fully repair patients’ sense of social connection. Previous research has shown that the lack of social interaction significantly accelerates cognitive decline and exacerbates depressive mood. Based on this, the study introduces positive psychology theory into the field of psychotherapy and designs a social human-computer interaction system to provide a low-risk digital intervention approach for elderly mental rehabilitation. This achievement has important clinical significance for alleviating loneliness in the elderly population and constructing integrated rehabilitation programs. Methods The study selected 80 elderly patients with mild depression or social withdrawal who met the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Divide all subjects into a control group and an experimental group, with 40 people in each group. The control group received routine mental care and health education, while the experimental group introduced a social human-computer interaction system based on positive psychology for intervention. The expected duration is 16 weeks, with 3 sessions per week and each session lasting 1 hour. The system design includes modules such as advantage check-in, positive storytelling, and virtual social communities, mainly guiding patients to reshape their social motivation through positive feedback. The study used multidimensional scales for pre-test and post test evaluation, including Positive and Negative Syndrome Scale (PANSS), Geriatric Depression Scale (GDS-15), and Social Disability Screening Schedule (SDSS), to verify the actual effectiveness of the interactive system in psychotherapy. Results Analysis shows that the GDS-15 score of the experimental group decreased from 10.42 points to 5.15 points, significantly better than the control group (p<.05). In the SDSS social function assessment, the score of the experimental group was only 6.42 points, a decrease of nearly half compared to before the intervention, reflecting a significant improvement in patients’ social withdrawal behavior. In addition, the intervention effect of the experimental group on PANSS negative symptoms was significant, decreasing from 22.15 points to 14.28 points, and the difference was statistically significant (p<.05). The control group only dropped from 22.30 points to 20.15 points. Positive psychology intervention can effectively activate patients’ emotional motivation. Discussion The social human-computer interaction system based on positive p","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":"299 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146169605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"251. The mediating effect of healing tourism consumption on youth's perceived social support for mental health","authors":"Min Liu","doi":"10.1093/schbul/sbag003.249","DOIUrl":"https://doi.org/10.1093/schbul/sbag003.249","url":null,"abstract":"Background Healing tourism, as a positive psychological intervention strategy, can improve individual mental health through emotion regulation, cognitive reshaping, and social interaction. However, existing research largely focuses on the direct impact of tourism experiences on subjective well-being, with insufficient attention paid to the internal mechanisms of mental health in young people, particularly the mediating role of perceived social support. Therefore, this study explores the impact of healing tourism consumption on the mental health of young people and systematically verifies the mediating effect of perceived social support in this relationship, aiming to provide empirical evidence for youth mental health intervention and tourism management policies. Methods This study employed a combination of cross-sectional questionnaires and Structural Equation Modeling (SEM) analysis. A total of 420 young participants aged 18-30 years were recruited, including university students and young professionals. Participants were categorized into high-spending, medium-spending, and low-spending groups based on the frequency and type of their healing tourism spending over the past 12 months. Mental health was assessed using the Mental Health Inventory (MHI-5), and perceived social support was measured using the Perceived Social Support Scale (PSSS). Control variables included gender, age, income level, and place of residence. Data analysis was conducted using SPSS 27 and AMOS 26 to examine the significance of direct, indirect, and mediating effects. Results Descriptive statistics showed that the mental health level of the high-consumption group (MHI-5: 74.3 ± 8.5) was significantly higher than that of the medium-consumption group and the low-consumption group, with a significant difference between groups (p<.001). Perceived social support also showed an increasing trend: the PSSS of the high-consumption group was 68.5 ± 7.4, the PSSS of the medium-consumption group was 61.9 ± 7.8, and the PSSS of the low-consumption group was 55.2 ± 8.1 (p<.001). SEM analysis further showed that the standardized coefficient of the direct effect of therapeutic tourism consumption on youth mental health was 0.42 (p<.01), and the mediating effect of perceived social support was 0.18 (p<.01), accounting for 30.0% of the total effect. Therefore, perceived social support plays a partial mediating role in the process of therapeutic tourism consumption improving mental health; that is, tourism consumption indirectly promotes youth mental health by enhancing perceived social support. Furthermore, between-group effect analysis showed that perceived social support accounted for 34% of the mediating effect on improved emotional stability, indicating that social interaction and emotional support are important mechanisms by which therapeutic tourism improves mental health. Discussion Healing tourism consumption can significantly improve the mental health of ","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":"30 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146169893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"260. Emotional disorder recognition and mental health intervention IN international Chinese education: an empirical study","authors":"Xing Fan","doi":"10.1093/schbul/sbag003.258","DOIUrl":"https://doi.org/10.1093/schbul/sbag003.258","url":null,"abstract":"Background As Chinese language learning gains global popularity, international Chinese learners increasingly face psychological pressures from language barriers, cultural shock, and academic adaptation, leading to emotional disorders like anxiety and depression. Previous studies have documented the high prevalence of their mental health issues but lack systematic exploration of context-specific recognition indicators and targeted interventions. To address this gap, this study aimed to construct a context-adaptive emotional disorder recognition system and verify the effectiveness of a comprehensive intervention model for these learners. Methods A mixed method of cross-sectional survey and quasi-experiment was adopted. A baseline survey was conducted on 620 international students using SAS, SDS, and a self-designed Chinese Learning Adaptation Stress Questionnaire, screening 120 students with emotional disorder tendencies (SAS ≥50 or SDS ≥53), who were randomly divided into an experimental group (n = 60) and a control group (n = 60). The experimental group received a 12-week comprehensive intervention (language support, cross-cultural guidance, group/individual counseling), while the control group only had regular mental health lectures. Post-intervention and 3-month follow-up measurements were conducted, with data analyzed via SPSS 26.0 and AMOS 24.0. Results The baseline detection rate of emotional disorder tendencies was 19.35% (120 cases). Significant differences in emotional disorder and learning adaptation stress scores were observed between the two groups after intervention (see Table 1). The experimental group maintained improvement at the 3-month follow-up, while the control group showed score rebound. Regression analysis identified Chinese proficiency improvement, cross-cultural adaptation enhancement, and group support participation as key intervention effect factors (all p<.05). Discussion This study has confirmed that the constructed adaptive emotional disorder recognition system can effectively detect the emotional disorder tendencies of international Chinese language learners, and promote academic adaptation with significant short-term and long-term effects. At the practical level, the research provides operational emotional disorder recognition tools and intervention plans for Chinese international education institutions, helping teachers to timely detect and intervene in learners' mental health issues; At the theoretical level, it enriches the research results on mental health in the field of Chinese international education and provides a new perspective for exploring the interactive mechanism between language learning and mental health. The research has limitations such as a small sample size and limited coverage of learners' nationalities. In the future, the sample scope can be expanded to include diverse scenarios such as online Chinese learning, to explore the long-term dynamic changes in emotional disorders among interna","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":"18 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146169894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"242. Correlation between anxiety symptoms and psychological rehabilitation in patients with diabetic foot ulcer","authors":"Haiyang Deng, Yasong Deng","doi":"10.1093/schbul/sbag003.240","DOIUrl":"https://doi.org/10.1093/schbul/sbag003.240","url":null,"abstract":"Background Diabetic foot ulcers, as one of the serious chronic complications of diabetes, not only cause limb pain, restricted movement and increased risk of infection in patients, but also often accompany significant psychological distress, especially anxiety symptoms. Anxiety may further affect patients' treatment compliance, self-management behavior and overall rehabilitation process. However, systematic research on the association between anxiety symptoms and psychological rehabilitation in patients with diabetic foot ulcers is still relatively insufficient at present. Therefore, the study adopted a scheme combining cross-sectional investigation and longitudinal follow-up, aiming to explore the correlation between anxiety symptoms and the psychological rehabilitation level of patients with diabetic foot ulcers. Methods A total of 120 patients diagnosed with diabetic foot ulcers were recruited for the study. Their Anxiety symptoms were evaluated using the Generalized Anxiety Disorder-7 Scale (GAD-7). And the level of psychological Rehabilitation was evaluated using the Diabetes Psychosocial Rehabilitation Assessment Scale (DPRAS). Meanwhile, the sociodemographic data of the patients, the severity of ulcers, the course of the disease and clinical indicators such as glycated hemoglobin were collected. Three months later, the same batch of patients were followed up again to reevaluate the above psychological indicators, and the ulcer healing situation and readjustment rate were recorded. Correlation analysis, multiple linear regression and path analysis and other methods were adopted to investigate the association between anxiety symptoms and various dimensions of psychological rehabilitation and its changing patterns over time. Results The results showed that the anxiety symptoms (total score of GAD-7) of patients with diabetic foot ulcers were significantly negatively correlated with the total score of psychological rehabilitation (r = -0.62, p<.01). After controlling for factors such as clinical severity, anxiety symptoms remained an independent predictor of psychological rehabilitation level (β = -0.48, p<.001). The longitudinal analysis results indicated that the psychological rehabilitation score of the high anxiety group was (52.7 ± 6.1) during follow-up, which was significantly lower than that of the low anxiety group (73.4 ± 5.9) (p<.01). Meanwhile, the complete ulcer healing rate in the high anxiety group (32.4%) was significantly lower than that in the low anxiety group (58.6%) (p<.05). Discussion The research results show that anxiety symptoms are closely related to the psychological rehabilitation level of patients with diabetic foot ulcers. A higher degree of anxiety not only corresponds to poor psychological adaptation and quality of life, but may also have an adverse impact on ulcer healing and clinical prognosis. In the routine treatment of diabetic foot ulcers, anxiety should be systematically screene","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":"1 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146169445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"111. The positive effects of team sports on college students’ mental health","authors":"Jialin Li","doi":"10.1093/schbul/sbag003.110","DOIUrl":"https://doi.org/10.1093/schbul/sbag003.110","url":null,"abstract":"Background With increasing pressure in modern society, the mental health of university students has received growing attention. Team sports, as an effective form of physical activity, not only help improve physical health but may also have a positive impact on mental well-being. Existing research indicates that sports can help alleviate psychological stress and anxiety among university students by promoting physical health and improving emotional state. However, the specific mechanisms and effects of team sports on university students’ mental health remain unclear, especially in the area of mental health therapy. Therefore, this study aims to explore the positive effects of team sports on university students’ mental health and provide data support, hoping to offer new insights for mental health intervention among university students. Methods This study selected 300 college students from three universities, dividing them into a sports group (n = 150) and a control group (n = 150). The sports group participated in a 12-week team sports program, including twice-weekly, 60-minute structured team activities (such as basketball and volleyball), supervised by professional coaches. The control group maintained their daily activities without any structured sports intervention. Standardized mental health scales were used for assessment, including the Beck Depression Inventory (BDI), the State–Trait Anxiety Inventory (STAI), and a mental resilience assessment. Furthermore, mental health assessment data before and after the sports program were compared using statistical analysis methods to analyze the impact of team sports on the mental health of college students. Results The results showed that the mental health of university students in the sports group significantly improved after participating in team sports. Specifically, the BDI score in the sports group decreased from an average of 15.4 ± 3.1 to 8.2 ± 2.7, indicating a significant reduction in depression (p<.01); the STAI score decreased from 30.1 ± 4.5 to 22.3 ± 4.0, indicating a reduction in anxiety (p<.05). Furthermore, the psychological resilience score significantly increased from 40.5 ± 5.2 to 49.6 ± 4.8 (p<.01). The control group showed no significant changes. The data indicate that team sports have a positive impact on the mental health of university students, particularly in alleviating anxiety and improving psychological resilience. Comprehensive analysis confirms that team sports have a positive effect on the mental health of university students. Discussion The research results indicate that team sports can effectively alleviate depression and anxiety among college students and improve their psychological resilience, which has a positive effect on their mental health. Through team activities, students not only gain physical exercise but also enhance emotional support through teamwork and social interaction, which contributes to improved mental health. Future research ca","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":"299 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146169495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"263. Experience differences and adaptive design strategies for mental health interactive products across different age groups","authors":"Xu Li","doi":"10.1093/schbul/sbag003.261","DOIUrl":"https://doi.org/10.1093/schbul/sbag003.261","url":null,"abstract":"Background Digital mental health interactive products have gradually become important tools for emotion regulation, psychological state monitoring, and auxiliary intervention for mental disorders. These products demonstrate advantages of low cost, sustainability, and high accessibility in long-term follow-up and non-pharmacological intervention for populations related to schizophrenia. However, substantial differences exist among users of different age groups in information processing ability, interaction familiarity, emotional feedback sensitivity, and technology acceptance. These differences directly affect product usability, emotional intervention effectiveness, and user adherence. Existing studies primarily evaluate interaction experience from an overall user perspective and lack quantitative comparative analyses across age groups. Therefore, this study analyzed the differences in experience of interactive mental health products among users of different age groups and proposed corresponding adaptation design strategies in order to promote the refined application of interactive mental health products in schizophrenia-related application scenarios. Methods A deployed mental health interactive product was selected as the research platform. A comparative experimental design based on age groups was adopted, recruiting a total of 126 participants divided into three groups aged 18-29 years, 30-44 years, and 45-60 years. All participants completed three types of tasks under a unified experimental environment, including emotion self-assessment, cognitive training, and emotion feedback interaction. Objective interaction indicators, including task completion time, click path length, misoperation rate, and functional module usage frequency, were automatically recorded by the system. In addition, standardized user experience questionnaires and emotion self-assessment scales were used to quantitatively evaluate subjective satisfaction, emotional stability, and changes in psychological comfort. One-way analysis of variance was applied to examine significant differences among age groups, followed by post hoc tests to further identify the sources of differences. Results The results showed significant differences among age groups in interaction efficiency, operational accuracy, and emotional improvement outcomes with p<.05. Users aged 18-29 years demonstrated the highest task completion efficiency, with an average completion time of 2.84 ± 0.63 min and deeper functional exploration, but exhibited a relatively limited improvement in emotional scores of only 12.47%. Users aged 30-44 years achieved the best performance in functional completeness and interaction stability, with the lowest misoperation rate and an overall satisfaction score of 4.31 ± 0.52. Users aged 45-60 had the highest rate of misoperation under the initial conditions, but after reducing the interaction level and strengthening visual cues, their emotional stability score improved by 18.36","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":"48 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146169549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is it Possible To Identify Patients After Their First Hospitalization for a Psychotic Disorder Who Do Not Use Anti-Psychotics and are Not Later Rehospitalized?","authors":"Amir Krivoy, Jari Tiihonen, Johnatan Nissan, Arad Dotan, Dana Arnheim, Noa Menkes-Caspi, Sharon Taub, Heli Tuppurainen, Ellenor Mittendorfer-Rutz, Michael Davidson, John M Davis, Mark Weiser, Heidi Taipale","doi":"10.1093/schbul/sbaf011","DOIUrl":"10.1093/schbul/sbaf011","url":null,"abstract":"<p><strong>Background: </strong>Guidelines issued by professional organizations recommend that all patients with psychotic disorders who have had several psychotic relapses, continue maintenance anti-psychotic treatment. However, some patients discontinue anti-psychotics and do not later relapse. This study attempted to characterize those patients with psychotic disorders early in their disease not taking maintenance antipsychotics, who were not later hospitalized.</p><p><strong>Study design: </strong>This population-based cohort study combined registry data on patients diagnosed in their first psychotic episode (ICD 10 code: F20-29) from Sweden (n = 20 848), and Israel (n = 10 045), and followed them for up to 7 years for re-hospitalization or death. Multivariate analyses assessed sociodemographic and clinical risk factors predicting rehospitalization or death in patients with one hospitalization and did not fill prescriptions for antipsychotics; results from Sweden and Israel were then meta-analyzed.</p><p><strong>Study results: </strong>The main analysis of this paper included 1611 patients from Sweden and 1607 from Israel. Male gender (adjusted hazard ratio [aHR], 1.57; 95% confidence interval [CI], 1.16-2.13) and a diagnosis of narrowly defined schizophrenia (F20.0-F20.9; aHR, 1.85; 95% CI, 1.55-2.2) were associated with increased risk of a second hospitalization or death among those who did not use antipsychotics. No sociodemographic or clinical characteristics were associated with a decreased risk of a second hospitalization or death.</p><p><strong>Conclusions: </strong>Based on registry data, it was not possible to characterize, in a clinically meaningful way, those patients who can safely discontinue anti-psychotic medications and not be re-hospitalized or die. Male gender and a diagnosis of narrowly defined schizophrenia were associated with an increased risk of later relapse.</p>","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12809860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relapse Following Electroconvulsive Therapy for Schizophrenia: A Systematic Review and Meta-analysis.","authors":"Nobuatsu Aoki, Aran Tajika, Taro Suwa, Hirotsugu Kawashima, Kazuyuki Yasuda, Toshiyuki Shimizu, Niina Uchinuma, Hirotaka Tominaga, Xiao Wei Tan, Azriel H K Koh, Phern Chern Tor, Stevan Nikolin, Donel Martin, Masaki Kato, Colleen Loo, Toshihiko Kinoshita, Toshi A Furukawa, Yoshiteru Takekita","doi":"10.1093/schbul/sbae169","DOIUrl":"10.1093/schbul/sbae169","url":null,"abstract":"<p><strong>Background: </strong>Evidence regarding schizophrenia relapse following acute electroconvulsive therapy (ECT) is sparse compared with that for depression, and we have no clear consensus on relapse proportions. We aimed to provide longitudinal information on schizophrenia relapse following acute ECT.</p><p><strong>Study design: </strong>This systematic review and meta-analysis included randomised controlled trials (RCTs) and observational studies on post-acute ECT relapse and rehospitalization for schizophrenia and related disorders. For the primary outcome, we calculated the post-acute ECT pooled relapse estimates at each timepoint (3, 6, 12, and 24 months post-acute ECT) using a random effects model. For subgroup analyses, we investigated post-acute ECT relapse proportions by the type of maintenance therapy.</p><p><strong>Study results: </strong>Among a total of 6413 records, 29 studies (3876 patients) met our inclusion criteria. The risk of bias was consistently low for all included RCTs (4 studies), although it ranged from low to high for observational studies (25 studies). Pooled estimates of relapse proportions among patients with schizophrenia responding to acute ECT were 24% (95% CI: 15-35), 37% (27-47), 41% (34-49), and 55% (40-69) at 3, 6, 12, and 24 months, respectively. When continuation/maintenance ECT was added to antipsychotics post-acute ECT, the 6-month relapse proportion was 20% (11-32).</p><p><strong>Conclusion: </strong>Relapse occurred mostly within 6 months post-acute ECT for schizophrenia, particularly within the first 3 months. Relapse proportions plateaued after 6 months, although more than half of all patients could be expected to relapse within 2 years. Further high-quality research is needed to optimise post-acute ECT treatment strategies in patients with schizophrenia.</p>","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12809790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}