Obesity最新文献

{"title":"Functional redundancy between glucocorticoid and mineralocorticoid receptors in mature corticotropin-releasing hormone neurons protects from obesity","authors":"Yu Liu,&nbsp;Dongfa Lin,&nbsp;Syeda Sadia Najam,&nbsp;Shangyuan Huang,&nbsp;Muyi Song,&nbsp;Chaweewan Sirakawin,&nbsp;Catherine Zhao,&nbsp;Haixia Jiang,&nbsp;Witold Konopka,&nbsp;Stephan Herzig,&nbsp;Ilya A. Vinnikov","doi":"10.1002/oby.24116","DOIUrl":"10.1002/oby.24116","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Here, we aimed to investigate the role of glucocorticoid and mineralocorticoid receptors (GRs and MRs, respectively) in the regulation of energy homeostasis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We used three mouse models with simultaneous deletion of GRs and MRs in either forebrain neurons, the paraventricular nucleus, or corticotropin-releasing hormone (CRH) neurons and compared them with wild-type controls or isolated knockout groups. In addition to body weight, food intake, energy expenditure, insulin sensitivity, fat/lean mass distribution, and plasma corticosterone levels, we also performed transcriptomic analysis of CRH neurons and assessed their response to melanocortinergic stimulation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Similar to global double-knockout models, deletion of GRs and MRs specifically in mature CRH neurons resulted in obesity. Importantly, the latter was accompanied by insulin resistance, but not increased plasma corticosterone levels. Transcriptomic analysis of these neurons revealed upregulation of several genes involved in postsynaptic signal transduction, including the <i>Ptk2b</i> gene, which encodes proline-rich tyrosine kinase 2. Knockout of both nuclear receptors leads to upregulation of <i>Ptk2b</i> in CRH neurons, which results in their diminished responsiveness to melanocortinergic stimulation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our data demonstrate the functional redundancy of GRs and MRs in CRH neurons to maintain energy homeostasis and prevent obesity. Simultaneous targeting of both receptors might represent an unprecedented approach to counteract obesity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 10","pages":"1885-1896"},"PeriodicalIF":4.2,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24116","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Competencies for health-enhancing physical activity are associated with body mass: results of an updated data pooling across 18 samples","authors":"Johannes Carl,&nbsp;Miaobing Zheng,&nbsp;Johanna Popp,&nbsp;Katharina Eckert,&nbsp;Wolfgang Geidl,&nbsp;Simon Blaschke,&nbsp;Julia Schmid,&nbsp;Eva Grüne,&nbsp;Leonard Oppermann,&nbsp;Anna-Maria Liphardt,&nbsp;Harriet Morf,&nbsp;Anja Weissenfels,&nbsp;Klaus Pfeifer","doi":"10.1002/oby.24121","DOIUrl":"10.1002/oby.24121","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Although previous studies have illuminated associations between body mass and physical activity (PA), there have been scant insights regarding the physical, cognitive, and motivational determinants of PA in relationship to body mass. This study aimed to model courses of competencies for health-enhancing PA across the spectrum of BMI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We used cross-sectional data of 3670 individuals (mean [SD]: BMI, 25.54 [5.71] kg/m²; age, 46.11 [14.96] years) from a large data pooling with 18 primary samples employing the PA-related health competence (PAHCO) instrument. ANCOVA determined differences in 10 PAHCO indicators by BMI categories (underweight, normal weight, overweight, and obesity). Covariate-adjusted multilevel models described the nonlinear courses of the PAHCO indicators across the BMI spectrum.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The levels of all 10 PAHCO indicators differed significantly among the BMI categories (<i>F</i> ≥ 14.8; <i>p</i> &lt; 0.001). All competencies for health-enhancing PA could be best described by cubic functions having their maximum around normal weight while regressing with underweight and with increasing grades of obesity (0.02 ≤ <span></span><math>\u0000 <mrow>\u0000 <msubsup>\u0000 <mi>R</mi>\u0000 <mrow>\u0000 <mi>m</mi>\u0000 <mi>arg</mi>\u0000 </mrow>\u0000 <mn>2</mn>\u0000 </msubsup>\u0000 </mrow></math> ≤ 0.31).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study adds to associations between BMI and PA levels by specifying individuals' multidimensional requirements for health-enhancing PA. The present findings call for an integration of physical, motivational, and cognitive factors in practices of PA promotion and sustainable obesity treatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 11","pages":"2161-2174"},"PeriodicalIF":4.2,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24121","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity increases the risk of hepatic fibrosis in young adults with type 2 diabetes mellitus: the need to screen","authors":"Anu Sharma,&nbsp;Eddison Godina Leiva,&nbsp;Srilaxmi Kalavalapalli,&nbsp;Romina Lomonaco,&nbsp;Stephen A. Marangi,&nbsp;Enrique Valdez Saenz,&nbsp;Maria A. Gonzalez,&nbsp;Andrea Ortiz Rocha,&nbsp;Nathaly Cuervo Pardo,&nbsp;Jens Rosenberg,&nbsp;Pierre Bedossa,&nbsp;Fernando Bril,&nbsp;Diana Barb,&nbsp;Kenneth Cusi","doi":"10.1002/oby.24130","DOIUrl":"10.1002/oby.24130","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The objective of this study was to determine the prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) in young compared with older adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Individuals (<i>n</i> = 1420) with (63%) and without type 2 diabetes mellitus (T2D; 37%) who attended internal medicine clinics and did not have a known history of MASLD underwent laboratory evaluation and transient elastography to assess for hepatic steatosis and fibrosis. Magnetic resonance elastography and liver biopsy were recommended when indicated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 243 participants were ages &lt;45 years, and 1177 were ages ≥45 years. Obesity, T2D, and metabolic syndrome were highly prevalent in young adults. Frequencies of steatosis and fibrosis were high in young adults (50.2% and 7.5% vs. older adults 52.7% and 9.9%, respectively) and were significantly higher in those with both obesity and T2D (71.1% and 15.7%, respectively; <i>p</i> &lt; 0.01). In young adults, T2D and obesity were the strongest risk factors for hepatic fibrosis (odds ratios 4.33 [95% CI: 1.37–13.68] and 1.16 [95% CI: 1.07–1.25], respectively; <i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>There is a high prevalence of clinically significant hepatic fibrosis in young adults with cardiometabolic risk factors. Up to one in seven young adults with obesity and T2D had clinically significant hepatic fibrosis on elastography. This highlights the need to screen young adults with cardiometabolic risk factors for MASLD for early detection and intervention.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 10","pages":"1967-1974"},"PeriodicalIF":4.2,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain versus cardiometabolic health: a delicate balance in need of precision lifestyle medicine approaches","authors":"Jean-Pierre Després,&nbsp;Natalie Alméras","doi":"10.1002/oby.24119","DOIUrl":"10.1002/oby.24119","url":null,"abstract":"&lt;p&gt;Depression is a major cause of morbidity and has major consequences on quality of life, impacting absenteeism, productivity at work, and health care costs [&lt;span&gt;(1)&lt;/span&gt;]. In 2023, 24% of adult women and 11% of adult men were treated for depressive symptoms [&lt;span&gt;(2)&lt;/span&gt;]. Because some antidepressants (AD) are known to have an impact on body weight [&lt;span&gt;(3)&lt;/span&gt;], the balance between managing mental health versus limiting adiposity-related cardiometabolic risk remains an important dilemma in clinical practice.&lt;/p&gt;&lt;p&gt;Furthermore, we have substantial evidence from more than three decades of cardiometabolic imaging (computed tomography [CT] or magnetic resonance imaging [MRI]) studies demonstrating that, for the same body mass index (BMI), there are considerable individual differences in body composition and regional adipose tissue distribution [&lt;span&gt;(4)&lt;/span&gt;]. For instance, it is now well established that visceral adipose tissue (VAT) is the body fat compartment most closely associated with insulin resistance and features of the metabolic syndrome that increase risk of type 2 diabetes and cardiovascular disease [&lt;span&gt;(5)&lt;/span&gt;]. We also understand that excess VAT is a marker of the relative inability of subcutaneous adipose tissue to expand and act as a metabolic sink, leading to deposition of fat not only in the abdominal cavity but also in usually lean tissues such as the heart, liver, kidney, pancreas, and skeletal muscle, a phenomenon referred to as ectopic fat deposition.&lt;/p&gt;&lt;p&gt;Andersson et al. took the opportunity of having access to the now-famous UK Biobank imaging data (&lt;i&gt;n&lt;/i&gt; = 40,174) to retrospectively examine whether AD (selective serotonin reuptake inhibitors and tricyclic antidepressants) users would display differences in body fat distribution and muscle composition compared with sex-, age-, and BMI-matched nonusers [&lt;span&gt;(6)&lt;/span&gt;]. The authors report that selective serotonin reuptake inhibitor users had higher levels of VAT and less muscle volume combined with greater fat infiltration than control individuals. Sex differences were also found in BMI gained over time (women &gt; men). Although an increased risk of cardiovascular disease (men) and type 2 diabetes was found among tricyclic antidepressant users, the specific contribution of changes in muscle composition to such increased risks could not be determined with certainty.&lt;/p&gt;&lt;p&gt;The paper by Andersson et al. addresses an important topic because some AD medications have been reported to induce weight gain, with differences observed among classes and specific molecules. The paper also nicely demonstrates that changes (or lack of changes) in body weight could sometimes be misleading in order to track clinically relevant variations in body composition with significant consequences on cardiometabolic health.&lt;/p&gt;&lt;p&gt;This paper presents a large amount of data from several relevant exploratory analyses providing additional evidence that monitoring body weight ov","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 10","pages":"1795-1796"},"PeriodicalIF":4.2,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24119","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NADPH oxidases in healthy white adipose tissue and in obesity: function, regulation, and clinical implications","authors":"François R. Jornayvaz,&nbsp;Karim Gariani,&nbsp;Emmanuel Somm,&nbsp;Vincent Jaquet,&nbsp;Karim Bouzakri,&nbsp;Ildiko Szanto","doi":"10.1002/oby.24113","DOIUrl":"10.1002/oby.24113","url":null,"abstract":"<p>Reactive oxygen species, when produced in a controlled manner, are physiological modulators of healthy white adipose tissue (WAT) expansion and metabolic function. By contrast, unbridled production of oxidants is associated with pathological WAT expansion and the establishment of metabolic dysfunctions, most notably insulin resistance and type 2 diabetes mellitus. NADPH oxidases (NOXs) produce oxidants in an orderly fashion and are present in adipocytes and in other diverse WAT-constituent cell types. Recent studies have established several links between aberrant NOX-derived oxidant production, adiposity, and metabolic homeostasis. The objective of this review is to highlight the physiological roles attributed to diverse NOX isoforms in healthy WAT and summarize current knowledge of the metabolic consequences related to perturbations in their adequate oxidant production. We detail WAT-related alterations in preclinical investigations conducted in NOX-deficient murine models. In addition, we review clinical studies that have employed NOX inhibitors and currently available data related to human NOX mutations in metabolic disturbances. Future investigations aimed at understanding the integration of NOX-derived oxidants in the regulation of the WAT cellular redox network are essential for designing successful redox-related precision therapies to curb obesity and attenuate obesity-associated metabolic pathologies.</p>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 10","pages":"1799-1811"},"PeriodicalIF":4.2,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24113","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poor muscle health and cardiometabolic risks associated with antidepressant treatment","authors":"Patrik Andersson,&nbsp;Jennifer Linge,&nbsp;Tiril P. Gurholt,&nbsp;Ida E. Sønderby,&nbsp;Guy Hindley,&nbsp;Ole A. Andreassen,&nbsp;Olof Dahlqvist Leinhard","doi":"10.1002/oby.24085","DOIUrl":"10.1002/oby.24085","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aims to investigate whether antidepressant users display differences in fat distribution and muscle composition relative to non-users and to explore risk factors for developing cardiovascular disease (CVD) and type 2 diabetes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study used quantitative adipose and muscle tissue measures derived from magnetic resonance imaging data from UK Biobank (<i>N</i> = 40,174). Fat distribution and muscle composition of selective serotonin reuptake inhibitor (SSRI) and tricyclic antidepressant (TCA) users were compared with sex-, age-, and BMI-matched control individuals. Cox regression models were used to test for increased risk of developing CVD and type 2 diabetes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>SSRI users had more visceral fat, smaller muscle volume, and higher muscle fat infiltration compared with matched control individuals. Female users showed a larger increase in BMI over time compared with male users. However, male users displayed an unhealthier body composition profile. Male SSRI users also had an increased risk of developing CVD. Both male and female TCA users showed lower muscle volume and an increased risk of developing type 2 diabetes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Adverse changes in body composition of antidepressant users are not captured by tracking the body weight or the BMI of the patients. These changes may lead to a worsened cardiometabolic risk profile.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 10","pages":"1857-1869"},"PeriodicalIF":4.2,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24085","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in the secular change in waist circumference relative to BMI in five countries from 1997 to 2020","authors":"Luz M. Sánchez-Romero,&nbsp;Janine Sagaceta-Mejía,&nbsp;Jennifer S. Mindell,&nbsp;Álvaro Passi-Solar,&nbsp;Antonio Bernabé-Ortiz,&nbsp;Lizbeth Tolentino-Mayo,&nbsp;Alison Moody,&nbsp;Shaun Scholes","doi":"10.1002/oby.24110","DOIUrl":"10.1002/oby.24110","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The objective of this study was to quantify changes over time in waist circumference (WC) relative to BMI by sex in the Americas (United States, Mexico, Chile, and Peru) and England.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data from adults aged 25 to 64 years between 1997 and 2020 were analyzed, and US data were stratified by race and ethnicity groups. Sex-specific BMI and WC means and obesity and abdominal obesity prevalence were compared between the first and last surveys. Using data from all survey years, secular changes across the BMI and WC distributions were estimated, applying quantile regression models. BMI was added as a predictor of WC to estimate secular changes in WC relative to BMI. Interaction terms were included in all models to evaluate differences by sex.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>BMI and WC (except for Peru) showed larger secular increases at the upper-tails of the distributions in both sexes. Increases at the 50th and 75th WC percentiles relative to BMI were more pronounced in women than in men, with larger increases in US non-Hispanic White individuals and in England. In men, increases in WC independent of BMI were most evident in Mexico.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Disease risk associated with visceral fat is potentially underestimated by national surveillance efforts that quantify only secular changes in BMI.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 10","pages":"1934-1947"},"PeriodicalIF":4.2,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24110","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orexins mitigate obesity-associated dysfunctions in mice","authors":"Anne Blais,&nbsp;Isabelle Denis,&nbsp;Mireille Andriamihaja,&nbsp;Valérie Gratio,&nbsp;Gaelle Champeil-Potokar,&nbsp;Samira Laouirem,&nbsp;Anais Chassac,&nbsp;Anne Couvelard,&nbsp;Valérie Paradis,&nbsp;Thierry Voisin,&nbsp;Anne-Marie Davila,&nbsp;Alain Couvineau","doi":"10.1002/oby.24120","DOIUrl":"10.1002/oby.24120","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Obesity is a chronic disease that affects more than 400 million adults with severe comorbidities. The search for new treatments to reduce its negative consequences is necessary. Orexins are hypothalamic neuropeptides involved in various physiological processes related to obesity. The aim of this study was to investigate the consequences of chronic orexin-A treatment in mouse models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Female wild-type C57BL/6 mice that were obesity-prone or obesity-resistant and mice that were deficient for orexin receptors were fed with a high-fat diet. Glucose tolerance, indirect calorimetry, expression of brain neuropeptides and receptors, microglial activation, and microbiota were determined to evaluate the role of orexins on metabolic flexibility.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Orexin-A reduces weight gain in obesity-prone mice. This reduction is associated with a decrease in body fat, food intake, steatosis, and insulin resistance, as well as alterations of intestinal microbiota composition. A decreased expression of orexin receptors and neuropeptides involved in food intake was also observed in the hypothalamus.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our data support the notion that orexin receptor signaling is involved in different aspects of energy metabolism and can mitigate several dysfunctions associated with obesity, suggesting that orexin receptors can represent new targets for obesity treatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 10","pages":"1897-1909"},"PeriodicalIF":4.2,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24120","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiobesity medications in active-duty military personnel","authors":"Brandon M. Roberts,&nbsp;Adam W. Potter,&nbsp;Geoffrey C. Chin,&nbsp;Karl E. Friedl","doi":"10.1002/oby.24136","DOIUrl":"10.1002/oby.24136","url":null,"abstract":"","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 10","pages":"1797-1798"},"PeriodicalIF":4.2,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142265669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A group prenatal care intervention reduces gestational weight gain and gestational diabetes in American Samoan women","authors":"Nicola L. Hawley,&nbsp;Kima Faasalele-Savusa,&nbsp;Mata'uitafa Faiai,&nbsp;Lynette Suiaunoa-Scanlan,&nbsp;Miracle Loia,&nbsp;Jeannette R. Ickovics,&nbsp;Erica Kocher,&nbsp;Christopher Piel,&nbsp;Madison Mahoney,&nbsp;Rachel Suss,&nbsp;Marcela Trocha,&nbsp;Rochelle K. Rosen,&nbsp;Bethel T. Muasau-Howard","doi":"10.1002/oby.24102","DOIUrl":"10.1002/oby.24102","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The objective of this study was to determine the preliminary effectiveness of an intervention to mitigate adverse pregnancy outcomes associated with pre-pregnancy obesity in American Samoa.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We enrolled <i>n</i> = 80 low-risk pregnant women at &lt;14 weeks' gestation. A complete case analysis was conducted with randomized group assignment (group prenatal care-delivered intervention vs. one-on-one usual care) as the independent variable. Primary outcomes were gestational weight gain and postpartum weight change. Secondary outcomes included gestational diabetes screening and exclusive breastfeeding at 6 weeks post partum. Other outcomes reported include gestational diabetes incidence, preterm birth, mode of birth, infant birth weight, and macrosomia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Gestational weight gain was lower among group versus usual care participants (mean [SD], 9.46 [7.24] kg vs. 14.40 [8.23] kg; <i>p</i> = 0.10); postpartum weight change did not differ between groups. Although the proportion of women who received adequate gestational diabetes screening (78.4% group; 65.6% usual care) was similar, there were clinically important between-group differences in exclusive breastfeeding (44.4% group; 25% usual care), incidence of gestational diabetes (27.3% group; 40.0% usual care), and macrosomia (8.3% group; 29.0% usual care).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>It may be possible to address multiple risk factors related to intergenerational transmission of obesity in this high-risk setting using a group care-delivered intervention.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 10","pages":"1833-1843"},"PeriodicalIF":4.2,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142224412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}