Obesity最新文献_第7页

Sensory nutrition: lessons learned and opportunities 感官营养：经验教训与机遇。

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity

Pub Date : 2024-07-17 DOI: 10.1002/oby.24089

Richard D. Mattes

引用次数: 0

Fas (CD95) expression in adipocytes contributes to diet-induced obesity 脂肪细胞中 Fas（CD95）的表达是饮食诱发肥胖的原因之一。

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity

Pub Date : 2024-07-17 DOI: 10.1002/oby.24092

Stephan Wueest, Chiara Scaffidi, Pim P. van Krieken, Nils K. Konrad, Christian Koch, Michael S. F. Wiedemann, Anne Goergen, Marcela Borsigova, Ioannis G. Lempesis, Jonas Fullin, Konstantinos N. Manolopoulos, Steffen Böttcher, Gijs H. Goossens, Matthias Blüher, Daniel Konrad

Objective

Induction of browning in white adipose tissue (WAT) increases energy expenditure and may be an attractive target for the treatment of obesity. Since activation of Fas (CD95) induces pathways known to blunt expression of uncoupling protein 1 (UCP1), we hypothesized that Fas expression in adipocytes inhibits WAT browning and thus contributes to the development of obesity.

Methods

Adipocyte-specific Fas knockout (Fas^Δadipo) and control littermate (Fas^F/F) mice were fed a regular chow diet or a high-fat diet (HFD) for 20 weeks. Energy expenditure was assessed by indirect calorimetry, and browning was determined in subcutaneous WAT. In vitro, UCP1 was analyzed in subcutaneous murine adipocytes treated with or without Fas ligand. Moreover, FAS expression in WAT was correlated to UCP1 and percentage of body fat in human individuals.

Results

HFD-fed Fas^Δadipo mice displayed reduced body weight gain and blunted adiposity compared to control littermates. Concomitantly, whole-body energy expenditure and WAT browning were elevated. In cultured adipocytes, Fas ligand treatment blunted isoproterenol-induced UCP1 protein levels. In support of these findings in rodents, FAS expression in WAT correlated negatively with UCP1 but positively with adiposity in human individuals.

Conclusions

Fas activation in adipocytes contributes to HFD-associated adiposity in rodents and may be a therapeutic target to reduce obesity and associated diseases.

目的：诱导白脂肪组织（WAT）褐变可增加能量消耗，可能是治疗肥胖症的一个有吸引力的靶点。由于 Fas（CD95）的活化会诱导已知的阻碍解偶联蛋白 1（UCP1）表达的途径，我们假设脂肪细胞中 Fas 的表达会抑制白脂肪组织的褐变，从而导致肥胖症的发生：方法：对脂肪细胞特异性 Fas 基因敲除（FasΔadipo）小鼠和对照组同窝小鼠（FasF/F）喂食普通饲料或高脂饲料（HFD）20 周。能量消耗通过间接热量计进行评估，皮下脂肪褐变的测定也通过间接热量计进行。在体外，对使用或不使用 Fas 配体处理的小鼠皮下脂肪细胞中的 UCP1 进行了分析。此外，FAS在WAT中的表达与UCP1和人体脂肪百分比相关：结果：与对照组小鼠相比，以高密度脂蛋白饲料喂养的 FasΔadipo 小鼠体重增加减少，脂肪含量降低。同时，全身能量消耗和脂肪细胞褐变增加。在培养的脂肪细胞中，Fas 配体处理会减弱异丙肾上腺素诱导的 UCP1 蛋白水平。与啮齿类动物的这些发现相印证的是，FAS在WAT中的表达与UCP1呈负相关，但与人类的脂肪率呈正相关：结论：啮齿类动物脂肪细胞中的 Fas 激活导致了高氟酸脱硫相关性肥胖，可能是减少肥胖及相关疾病的治疗靶点。

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引用次数: 0

Obesity- and diet-induced plasticity in systems that control eating and energy balance 控制进食和能量平衡的系统因肥胖和饮食引起的可塑性。

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity

Pub Date : 2024-07-15 DOI: 10.1002/oby.24060

Carrie R. Ferrario, Heike Münzberg-Gruening, Linda Rinaman, J. Nicholas Betley, Stephanie L. Borgland, Monica Dus, Debra A. Fadool, Kathryn F. Medler, Gregory J. Morton, Darleen A. Sandoval, Claire B. de La Serre, Sarah A. Stanley, Kristy L. Townsend, Alan G. Watts, Padma Maruvada, Diana Cummings, Bradley M. Cooke

In April 2023, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), in partnership with the National Institute of Child Health and Human Development, the National Institute on Aging, and the Office of Behavioral and Social Sciences Research, hosted a 2-day online workshop to discuss neural plasticity in energy homeostasis and obesity. The goal was to provide a broad view of current knowledge while identifying research questions and challenges regarding neural systems that control food intake and energy balance. This review includes highlights from the meeting and is intended both to introduce unfamiliar audiences with concepts central to energy homeostasis, feeding, and obesity and to highlight up-and-coming research in these areas that may be of special interest to those with a background in these fields. The overarching theme of this review addresses plasticity within the central and peripheral nervous systems that regulates and influences eating, emphasizing distinctions between healthy and disease states. This is by no means a comprehensive review because this is a broad and rapidly developing area. However, we have pointed out relevant reviews and primary articles throughout, as well as gaps in current understanding and opportunities for developments in the field.

2023 年 4 月，美国国立糖尿病、消化道疾病和肾脏疾病研究所（NIDDK）与美国国立儿童健康与人类发展研究所、美国国立老龄化研究所以及行为和社会科学研究办公室合作举办了为期两天的在线研讨会，讨论能量平衡和肥胖症中的神经可塑性。会议的目的是提供对当前知识的广泛了解，同时确定有关控制食物摄入和能量平衡的神经系统的研究问题和挑战。本综述包括会议的重点内容，旨在向不熟悉能量平衡、进食和肥胖症核心概念的读者介绍这些概念，并重点介绍具有这些领域背景的读者可能特别感兴趣的这些领域的最新研究。本综述的首要主题是探讨调节和影响进食的中枢和外周神经系统的可塑性，强调健康状态和疾病状态之间的区别。这绝不是一篇全面的综述，因为这是一个广泛且发展迅速的领域。不过，我们还是指出了相关的综述和主要文章，以及该领域目前认识上的差距和发展机遇。

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引用次数: 0

Anthropometry for predicting cardiometabolic disease risk factors in adolescents 预测青少年心脏代谢疾病风险因素的人体测量法。

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity

Pub Date : 2024-07-12 DOI: 10.1002/oby.24090

Luyu Xie, Joohan Kim, Jaime P. Almandoz, John Clark, M. Sunil Mathew, Bethany R. Cartwright, Sarah E. Barlow, Steven E. Lipshultz, Sarah E. Messiah

Objective

Early screening prevents chronic diseases by identifying at-risk adolescents through anthropometric measurements, but predictive value in diverse groups is uncertain.

Methods

A cross-sectional analysis of 12- to 19-year-old individuals from the 2017–2018 National Health and Nutrition Examination Survey (NHANES) assessed the predictive ability of BMI percentile, total body fat percentage, waist circumference (WC), and waist-hip ratio (WHR) for four cardiometabolic risk factors across race and ethnicity groups using receiver operating characteristic curves.

Results

The unweighted sample (N = 1194; 51.2% male individuals; 23.7% Hispanic, 13.2% non-Hispanic Black [NHB], 51.1% non-Hispanic White [NHW], 12.0% other/multirace) had a weighted prevalence of elevated blood pressure of 2.7%, hyperglycemia of 36.8%, hypertriglyceridemia of 4.8%, and low high-density lipoprotein (HDL) cholesterol of 15%. WHR (area under the curve [AUC] = 0.77), WC (AUC = 0.77), and BMI percentile (AUC = 0.73) outperformed total body fat percentage (AUC = 0.56) in predicting elevated blood pressure (p < 0.001 for all). BMI percentile was more accurate than total body fat percentage in predicting hypertriglyceridemia (AUC = 0.70 vs. 0.59; p = 0.02) and low HDL cholesterol (AUC = 0.69 vs. 0.59; p < 0.001). Race and ethnicity-based predictions varied: NHW adolescents had the highest AUC (0.89; p < 0.01) for elevated blood pressure prediction compared with Hispanic and NHB adolescents (AUC = 0.77 for both). Total body fat percentage was more accurate in predicting low HDL cholesterol among Hispanic versus NHW adolescents (AUC = 0.73 vs. 0.58; p = 0.04).

Conclusions

WHR, WC, and BMI percentile are better predictors of cardiometabolic risk factors in adolescents than total body fat percentage. Predictive abilities differed by race and ethnicity, highlighting the importance of tailored risk assessment strategies.

目的早期筛查可通过人体测量识别高危青少年，从而预防慢性疾病，但对不同群体的预测价值尚不确定：对2017-2018年美国国家健康与营养调查（NHANES）中12至19岁的个体进行横断面分析，利用接收器操作特征曲线评估BMI百分位数、总体脂百分比、腰围（WC）和腰臀比（WHR）对不同种族和族裔群体的四种心脏代谢风险因素的预测能力：非加权样本（N = 1194；51.2% 男性；23.7% 西班牙裔、13.2% 非西班牙裔黑人[NHB]、51.1% 非西班牙裔白人[NHW]、12.0% 其他/多种族）的加权患病率为：血压升高 2.7%、高血糖 36.8%、高甘油三酯血症 4.8%、低高密度脂蛋白胆固醇 15%。在预测血压升高方面，WHR（曲线下面积 [AUC] = 0.77）、WC（曲线下面积 [AUC] = 0.77）和 BMI 百分位数（曲线下面积 [AUC] = 0.73）优于总体脂率（曲线下面积 [AUC] = 0.56）：WHR、WC和BMI百分位数比体脂总百分比更能预测青少年的心脏代谢风险因素。不同种族和人种的预测能力各不相同，这凸显了量身定制风险评估策略的重要性。

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引用次数: 0

Response to review by Pan et al. 对 Pan 等人的评论的回应

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity

Pub Date : 2024-07-10 DOI: 10.1002/oby.24088

Ulf Holmbäck

引用次数: 0

Response to “Response to review by Pan et al.” 对 "对 Pan 等人评论的回应 "的回应

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity

Pub Date : 2024-07-10 DOI: 10.1002/oby.24087

Xin-Hui Pan, Yip Han Chin, Mark Y. Chan, Nicholas W. S. Chew

引用次数: 0

Dopamine production in neurotensin receptor 1 neurons is required for diet-induced obesity and increased day eating on a high-fat diet 多巴胺在神经紧张素受体1神经元中的分泌是饮食诱发肥胖和高脂饮食日进食量增加所必需的。

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity

Pub Date : 2024-07-09 DOI: 10.1002/oby.24066

Firozeh Farahmand, Michael Sidikpramana, Alyssa R. Gomez, Luis J. Rivera, Jacqueline R. Trzeciak, Sarah Sharif, Qijun Tang, Gina M. Leinninger, Ali D. Güler, Andrew D. Steele

Objective

This study aimed to determine a dopaminergic circuit required for diet-induced obesity in mice.

Methods

We created conditional deletion mutants for tyrosine hydroxylase (TH) using neurotensin receptor 1 (Ntsr1) Cre and other Cre drivers and measured feeding and body weight on standard and high-fat diets. We then used an adeno-associated virus to selectively restore TH to the ventral tegmental area (VTA) Ntsr1 neurons in conditional knockout (cKO) mice.

Results

Mice with cKO of Th using Vglut2-Cre, Cck-Cre, Calb1-Cre, and Bdnf-Cre were susceptible to obesity on a high-fat diet; however, Ntsr1-Cre Th cKO mice resisted weight gain on a high-fat diet and did not experience an increase in day eating unlike their wild-type littermate controls. Restoration of TH to the VTA Ntsr1 neurons of the Ntsr1-Cre Th cKO mice using an adeno-associated virus resulted in an increase in weight gain and day eating on a high-fat diet.

Conclusions

Ntsr1-Cre Th cKO mice failed to increase day eating on a high-fat diet, offering a possible explanation for their resistance to diet-induced obesity. These results implicate VTA Ntsr1 dopamine neurons as promoting out-of-phase feeding behavior on a high-fat diet that could be an important contributor to diet-induced obesity in humans.

目的：本研究旨在确定饮食诱导小鼠肥胖所需的多巴胺能回路：本研究旨在确定饮食诱导小鼠肥胖所需的多巴胺能回路：我们利用神经紧张素受体 1（Ntsr1）Cre 和其他 Cre 驱动因子创建了酪氨酸羟化酶（TH）的条件性缺失突变体，并测量了小鼠在标准和高脂饮食下的摄食量和体重。然后，我们使用腺相关病毒在条件性基因敲除（cKO）小鼠的腹侧被盖区（VTA）Ntsr1神经元中选择性地恢复TH：结果：使用Vglut2-Cre、Cck-Cre、Calb1-Cre和Bdnf-Cre对TH进行cKO的小鼠在高脂饮食中易患肥胖症；然而，Ntsr1-Cre Th cKO小鼠在高脂饮食中体重不会增加，而且与野生型同窝对照组不同，日进食量不会增加。使用腺相关病毒恢复Ntsr1-Cre Th cKO小鼠VTA Ntsr1神经元的TH，结果是在高脂饮食中体重增加和日进食量增加：结论：Ntsr1-Cre Th cKO小鼠在高脂饮食中不能增加日进食量，这为它们抵抗饮食诱导的肥胖提供了可能的解释。这些结果表明，VTA Ntsr1多巴胺神经元促进了高脂饮食中的失调摄食行为，这可能是饮食诱发人类肥胖症的一个重要原因。

{"title":"Dopamine production in neurotensin receptor 1 neurons is required for diet-induced obesity and increased day eating on a high-fat diet","authors":"Firozeh Farahmand, Michael Sidikpramana, Alyssa R. Gomez, Luis J. Rivera, Jacqueline R. Trzeciak, Sarah Sharif, Qijun Tang, Gina M. Leinninger, Ali D. Güler, Andrew D. Steele","doi":"10.1002/oby.24066","DOIUrl":"10.1002/oby.24066","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to determine a dopaminergic circuit required for diet-induced obesity in mice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We created conditional deletion mutants for tyrosine hydroxylase (TH) using neurotensin receptor 1 (<i>Ntsr1</i>) <i>Cre</i> and other <i>Cre</i> drivers and measured feeding and body weight on standard and high-fat diets. We then used an adeno-associated virus to selectively restore TH to the ventral tegmental area (VTA) Ntsr1 neurons in conditional knockout (cKO) mice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Mice with cKO of <i>Th</i> using <i>Vglut2-Cre</i>, <i>Cck-Cre</i>, <i>Calb1-Cre</i>, and <i>Bdnf-Cre</i> were susceptible to obesity on a high-fat diet; however, <i>Ntsr1-Cre</i> <i>Th</i> cKO mice resisted weight gain on a high-fat diet and did not experience an increase in day eating unlike their wild-type littermate controls. Restoration of TH to the VTA Ntsr1 neurons of the <i>Ntsr1-Cre</i> <i>Th</i> cKO mice using an adeno-associated virus resulted in an increase in weight gain and day eating on a high-fat diet.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p><i>Ntsr1-Cre</i> <i>Th</i> cKO mice failed to increase day eating on a high-fat diet, offering a possible explanation for their resistance to diet-induced obesity. These results implicate VTA Ntsr1 dopamine neurons as promoting out-of-phase feeding behavior on a high-fat diet that could be an important contributor to diet-induced obesity in humans.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 8","pages":"1448-1452"},"PeriodicalIF":4.2,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11269025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141560662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparing the metabolic signatures of obesity defined by waist circumference, waist-hip ratio, or BMI 比较以腰围、腰臀比或体重指数定义的肥胖代谢特征。

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity

Pub Date : 2024-07-05 DOI: 10.1002/oby.24070

Moustafa Al Hariri, Haya Al-Sulaiti, Najeha Anwardeen, Khaled Naja, Mohamed A. Elrayess

Objective

Measuring obesity is crucial for assessing health risks and developing effective prevention and treatment strategies. The most common methods used to measure obesity include BMI, waist circumference, and waist-hip ratio. This study aimed to determine the metabolic signatures associated with each measure of obesity in the Qatari population.

Methods

Metabolomics profiling was conducted to identify, quantify, and characterize metabolites in serum samples from the study participants. Inverse rank normalization, principal component analysis, and orthogonal partial least square-discriminant analysis were used to analyze the metabolomics data.

Results

This study revealed significant differences in metabolites associated with obesity based on different measurements. In men, phosphatidylcholine and phosphatidylethanolamine metabolites were significantly enriched in individuals classified as having obesity based on the waist-hip ratio. In women, significant changes were observed in leucine, isoleucine, and valine metabolism metabolites. Unique metabolites were found in the different categorization groups that could serve as biomarkers for assessing many obesity-related disorders.

Conclusions

This study identified unique metabolic signatures associated with obesity based on different measurements in the Qatari population. These findings contribute to a better understanding of the molecular pathways involved in obesity and may have implications for developing personalized prevention and treatment strategies.

目的：测量肥胖对评估健康风险和制定有效的预防和治疗策略至关重要。最常用的肥胖测量方法包括体重指数、腰围和腰臀比。本研究旨在确定卡塔尔人口中与每种肥胖测量方法相关的代谢特征：方法：对研究参与者的血清样本进行代谢组学分析，以确定、量化和描述代谢物的特征。采用反秩归一化、主成分分析和正交偏最小二乘法判别分析来分析代谢组学数据：结果：这项研究发现，根据不同的测量方法，与肥胖相关的代谢物存在明显差异。在男性中，磷脂酰胆碱和磷脂酰乙醇胺代谢物在根据腰臀比归类为肥胖的人群中明显富集。在女性中，亮氨酸、异亮氨酸和缬氨酸代谢物发生了明显变化。在不同的分类组中发现了独特的代谢物，这些代谢物可作为评估许多肥胖相关疾病的生物标志物：这项研究根据卡塔尔人口的不同测量结果，确定了与肥胖相关的独特代谢特征。这些发现有助于更好地了解肥胖的分子途径，并可能对制定个性化预防和治疗策略产生影响。

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引用次数: 0

The subcutaneous adipose transcriptome identifies a molecular signature of insulin resistance shared with visceral adipose 皮下脂肪转录组确定了与内脏脂肪共有的胰岛素抵抗分子特征。

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity

Pub Date : 2024-07-05 DOI: 10.1002/oby.24064

Mona Mashayekhi, Quanhu Sheng, Samuel S. Bailin, Lucas Massier, Jiawei Zhong, Mingjian Shi, Celestine N. Wanjalla, Thomas J. Wang, T. Alp Ikizler, Kevin D. Niswender, Curtis L. Gabriel, Julia Palacios, Rachel Turgeon-Jones, Cassandra F. Reynolds, James M. Luther, Nancy J. Brown, Saumya Das, Ingrid Dahlman, Jonathan D. Mosley, John R. Koethe, Mikael Rydén, Katherine N. Bachmann, Ravi V. Shah

Objective

The objective of this study was to identify the transcriptional landscape of insulin resistance (IR) in subcutaneous adipose tissue (SAT) in humans across the spectrum of obesity.

Methods

We used SAT RNA sequencing in 220 individuals with metabolic phenotyping.

Results

We identified a 35-gene signature with high predictive accuracy for homeostatic model of IR that was expressed across a variety of non-immune cell populations. We observed primarily “protective” IR associations for adipocyte transcripts and “deleterious” associations for macrophage transcripts, as well as a high concordance between SAT and visceral adipose tissue (VAT). Multiple SAT genes exhibited dynamic expression 5 years after weight loss surgery and with insulin stimulation. Using available expression quantitative trait loci in SAT and/or VAT, we demonstrated similar genetic effect sizes of SAT and VAT on type 2 diabetes and BMI.

Conclusions

SAT is conventionally viewed as a metabolic buffer for lipid deposition during positive energy balance, whereas VAT is viewed as a dominant contributor to and prime mediator of IR and cardiometabolic disease risk. Our results implicate a dynamic transcriptional architecture of IR that resides in both immune and non-immune populations in SAT and is shared with VAT, nuancing the current VAT-centric concept of IR in humans.

研究目的本研究旨在确定不同肥胖程度的人类皮下脂肪组织（SAT）中胰岛素抵抗（IR）的转录情况：方法：我们使用 SAT RNA 测序技术对 220 名进行了代谢表型分析的个体进行了研究：结果：我们确定了 35 个基因特征，它们对 IR 的稳态模型具有很高的预测准确性，这些基因在各种非免疫细胞群中都有表达。我们观察到脂肪细胞转录本主要与 "保护性 "红外相关，而巨噬细胞转录本则与 "有害性 "红外相关，而且 SAT 基因与内脏脂肪组织（VAT）高度一致。多个 SAT 基因在减肥手术 5 年后和胰岛素刺激下表现出动态表达。利用 SAT 和/或 VAT 中现有的表达定量性状位点，我们证明了 SAT 和 VAT 对 2 型糖尿病和体重指数的遗传效应大小相似：传统上，SAT 被认为是能量正平衡时脂质沉积的代谢缓冲器，而 VAT 则被认为是导致 IR 和心血管代谢疾病风险的主要因素。我们的研究结果表明，IR 的动态转录结构同时存在于 SAT 的免疫和非免疫人群中，并与 VAT 共享，从而对目前以 VAT 为中心的人类 IR 概念产生了微妙的影响。

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引用次数: 0

No causal associations of genetically predicted birth weight and life course BMI with thyroid function and diseases 遗传预测的出生体重和生命过程中的体重指数与甲状腺功能和疾病没有因果关系。

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity

Pub Date : 2024-07-02 DOI: 10.1002/oby.24095

Xiaoqin Zhou, Weiqiang Ruan, Jing Li, Ting Wang, Huizhen Liu, Guiying Zhang

Objective

Observational studies have suggested associations of birth weight, childhood BMI, and adulthood BMI with thyroid function or diseases. However, the causal relationships remain unclear due to residual confounding inherent in conventional epidemiological studies.

Methods

We performed a two-sample Mendelian randomization (MR) study to investigate causal relationships of genetically predicted birth weight, childhood BMI, and adulthood BMI with a range of clinically relevant thyroid outcomes. Additionally, we conducted a reverse MR analysis on adulthood BMI. Data on exposures and outcomes were obtained from large-scale genome-wide association study meta-analyses predominantly composed of individuals of European ancestry.

Results

The MR analysis revealed no evidence of causal associations of birth weight or BMI at different life stages with thyrotropin (TSH) levels, hypothyroidism, hyperthyroidism, autoimmune thyroid disorders, or thyroid cancer. Contrarily, thyroid cancer demonstrated a significant causal relationship with increased adulthood BMI (β = 0.010, 95% CI: 0.006–0.015; p = 5.21 × 10⁻⁶).

Conclusions

Our comprehensive MR did not find causal links of birth weight, childhood BMI, or adulthood BMI with thyroid diseases but provided evidence that thyroid cancer may play a role in weight gain. Our research findings offer valuable insights into the intricate relationship between body weight and thyroid health throughout an individual's life.

目的：观察性研究表明，出生体重、儿童期体重指数和成年期体重指数与甲状腺功能或疾病有关。然而，由于传统流行病学研究中固有的残余混杂因素，其因果关系仍不明确：我们进行了一项双样本孟德尔随机化（MR）研究，以调查遗传预测的出生体重、儿童期体重指数和成年期体重指数与一系列临床相关甲状腺结果的因果关系。此外，我们还对成年后的体重指数进行了反向 MR 分析。有关暴露和结果的数据来自大规模的全基因组关联研究荟萃分析，主要由欧洲血统的个体组成：MR分析显示，没有证据表明不同生命阶段的出生体重或体重指数与促甲状腺激素（TSH）水平、甲状腺功能减退症、甲状腺功能亢进症、自身免疫性甲状腺疾病或甲状腺癌存在因果关系。与此相反，甲状腺癌与成年期体重指数的增加有显著的因果关系（β = 0.010，95% CI：0.006-0.015；P = 5.21 × 10-6）：我们的综合 MR 没有发现出生体重、儿童期 BMI 或成年期 BMI 与甲状腺疾病的因果关系，但提供了甲状腺癌可能在体重增加中发挥作用的证据。我们的研究结果为了解体重与甲状腺健康之间错综复杂的关系提供了宝贵的见解。

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引用次数: 0