Pub Date : 2024-01-22DOI: 10.26554/sti.2024.9.1.7-16
N. Kusumawati, P. Setiarso, S. Muslim, Qonita Arky Hafidha, Sinta Anjas Cahyani, Fadlurachman Faizal Fachrirakarsie
Dye-Sensitized Solar Cells (DSSC) are photovoltaic devices that contain a dye that acts as a solar light acceptor. The use of dyesensitized solar cells to solve increasing energy demand and environmental problems still results in low efficiency values. In this study, optimization of DSSC components was carried out to increase DSSC efficiency by varying the thickness of the titanium dioxide (TiO2) semiconductor photoanode layer, polyvinylidene fluoride (PVDF) trap electrolyte membrane, and polyvinylidene fluoride nanofiber (PVDF NF) to obtain the optimum thickness. Scanning Electron Microscope (SEM) results of membrane thickness variation and titanium dioxide (TiO2) semiconductor photoanode coating showed the formation of nanofiber fibers composed of three-dimensional, porous, and diameter networks connected to the PVDF NF membrane. The increase in density and decrease in pore size, along with an increase in thickness and cracking as the TiO2 photoanode semiconductor layer increases, affect the electron transport rate of the DSSC. The higher particle density level will inhibit the electron transport rate, so it can reduce the efficiency of DSSC. The optimum thickness of the TiO2 semiconductor layer and PVDF NF electrolyte membrane of 0.20 mm and 0.35 mm can produce values, voltage, fill factor current density, and electrical efficiency of 500 mV, 2.7 x 10−3 mA.cm−2, 1.80%, and 2.40%, respectively.
{"title":"Optimization Thickness of Photoanode Layer and Membrane as Electrolyte Trapping Medium for Improvement Dye-Sensitized Solar Cell Performance","authors":"N. Kusumawati, P. Setiarso, S. Muslim, Qonita Arky Hafidha, Sinta Anjas Cahyani, Fadlurachman Faizal Fachrirakarsie","doi":"10.26554/sti.2024.9.1.7-16","DOIUrl":"https://doi.org/10.26554/sti.2024.9.1.7-16","url":null,"abstract":"Dye-Sensitized Solar Cells (DSSC) are photovoltaic devices that contain a dye that acts as a solar light acceptor. The use of dyesensitized solar cells to solve increasing energy demand and environmental problems still results in low efficiency values. In this study, optimization of DSSC components was carried out to increase DSSC efficiency by varying the thickness of the titanium dioxide (TiO2) semiconductor photoanode layer, polyvinylidene fluoride (PVDF) trap electrolyte membrane, and polyvinylidene fluoride nanofiber (PVDF NF) to obtain the optimum thickness. Scanning Electron Microscope (SEM) results of membrane thickness variation and titanium dioxide (TiO2) semiconductor photoanode coating showed the formation of nanofiber fibers composed of three-dimensional, porous, and diameter networks connected to the PVDF NF membrane. The increase in density and decrease in pore size, along with an increase in thickness and cracking as the TiO2 photoanode semiconductor layer increases, affect the electron transport rate of the DSSC. The higher particle density level will inhibit the electron transport rate, so it can reduce the efficiency of DSSC. The optimum thickness of the TiO2 semiconductor layer and PVDF NF electrolyte membrane of 0.20 mm and 0.35 mm can produce values, voltage, fill factor current density, and electrical efficiency of 500 mV, 2.7 x 10−3 mA.cm−2, 1.80%, and 2.40%, respectively.","PeriodicalId":21644,"journal":{"name":"Science and Technology Indonesia","volume":"90 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139606277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-22DOI: 10.26554/sti.2024.9.1.43-58
Poowadon Muenraya, Apichart Atipairin, T. Srichana, N. Changsan, Neelam Balekar, Somchai Sawatdee
Montelukast tablets are sold under the brand name Singulair and are used to control and prevent asthma symptoms. In this study, 10 mg film-coated montelukast tablets were developed as a generic drug in order to evaluate the pharmaceutical equivalent of the innovator’s products. The primary formulation ingredients used in all developed formulations (F1-F5) were the same as those described in the Singulair tablet package insert, except for formulations F3, F4, and F5, to which solubilizing enhancers were added to increase montelukast solubility. The core tablets were produced using the wet granulation method before being coated with HPMC polymer. FT-IR and DSC were used to determine drug and excipient compatibility. The micromeritic properties of the granules were assessed. The physicochemical properties of generated montelukast tablets and Singulair tablets were also investigated. The dissolution profiles of the tested drug and the innovator were assessed in a variety of pH mediums (pH 1.2, 4.5, 6.8, and water). The similarity (f2) and difference (f1) factors were computed. The accelerated and long-term stability of the tested drug in hot and humid climate zones was evaluated. The analytical method validation used in this study was ICH-acceptable for 8 parameters including specificity, range, linearity, accuracy, precision, limit of detection, limit of quantitation, and robustness. F1-F5 granules had similar properties, such as a pale-yellow color and excellent flow properties. There were no chemical interactions between montelukast and the excipients according to FT-IR and DSC analyses. The physical properties of all developed montelukast film-coated tablets were similar (average weight 212-218 mg; thickness 3.02-3.07 mm; assay 101-102% LA; disintegration time 3-4 min), except that the disintegration time of F3 was 8.10 min and that of F5 was 5.90 min, which was caused by the addition of poloxamer 188 to the formulation. In all mediums, only the F1 formula produced acceptable comparison dissolution profiles to Singulair. After 6 months of storage under accelerated and long-term conditions, the results showed the F1 formulation remained physically and chemically stable.
{"title":"Development of Pharmaceutical Equivalent Montelukast Sodium Immediate-Release, Film-Coated Tablets","authors":"Poowadon Muenraya, Apichart Atipairin, T. Srichana, N. Changsan, Neelam Balekar, Somchai Sawatdee","doi":"10.26554/sti.2024.9.1.43-58","DOIUrl":"https://doi.org/10.26554/sti.2024.9.1.43-58","url":null,"abstract":"Montelukast tablets are sold under the brand name Singulair and are used to control and prevent asthma symptoms. In this study, 10 mg film-coated montelukast tablets were developed as a generic drug in order to evaluate the pharmaceutical equivalent of the innovator’s products. The primary formulation ingredients used in all developed formulations (F1-F5) were the same as those described in the Singulair tablet package insert, except for formulations F3, F4, and F5, to which solubilizing enhancers were added to increase montelukast solubility. The core tablets were produced using the wet granulation method before being coated with HPMC polymer. FT-IR and DSC were used to determine drug and excipient compatibility. The micromeritic properties of the granules were assessed. The physicochemical properties of generated montelukast tablets and Singulair tablets were also investigated. The dissolution profiles of the tested drug and the innovator were assessed in a variety of pH mediums (pH 1.2, 4.5, 6.8, and water). The similarity (f2) and difference (f1) factors were computed. The accelerated and long-term stability of the tested drug in hot and humid climate zones was evaluated. The analytical method validation used in this study was ICH-acceptable for 8 parameters including specificity, range, linearity, accuracy, precision, limit of detection, limit of quantitation, and robustness. F1-F5 granules had similar properties, such as a pale-yellow color and excellent flow properties. There were no chemical interactions between montelukast and the excipients according to FT-IR and DSC analyses. The physical properties of all developed montelukast film-coated tablets were similar (average weight 212-218 mg; thickness 3.02-3.07 mm; assay 101-102% LA; disintegration time 3-4 min), except that the disintegration time of F3 was 8.10 min and that of F5 was 5.90 min, which was caused by the addition of poloxamer 188 to the formulation. In all mediums, only the F1 formula produced acceptable comparison dissolution profiles to Singulair. After 6 months of storage under accelerated and long-term conditions, the results showed the F1 formulation remained physically and chemically stable.","PeriodicalId":21644,"journal":{"name":"Science and Technology Indonesia","volume":"17 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139607278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-22DOI: 10.26554/sti.2024.9.1.103-112
A. Bader
This study reports the synthesizes of such as copper oxide (CuO) and nickel oxide (NiO) nanoparticles (NPs) by thermal decompositions of Schiff base complexes and their physical characterization. A polydentate Schiff base ligand, (E)-2-(((2-chlorobenzyl)imino)methyl)phenol (CIMP), was synthesized by condensing 2-chlorobenzylamine and 2-hydroxybenzaldehyde. The ligand was identified by melting point, FT-IR, UV-Vis, and (1H and 13C NMR) spectroscopy. Cu(II) and Ni(II) complexes were prepared by reacting CIMP with the corresponding molar ratio in a 1:1 (metal: ligand). The complexes (Com1 and Com2) were characterized by melting point, FT-IR, and UV-Vis spectroscopy. The FT-IR spectra of the (Com1 and Com2) showed that the deprotonated CIMP ligand coordinated to the Ni(II) and Cu(II) metal ions through the azomethine nitrogen, aryl chloride, chlorine, and phenolic oxygen atoms. To determine the crystalline structure of the synthesized products, X-ray powder diffraction (XRD) and scanning electron microscopy (SEM) techniques were employed. The formation of copper oxide and nickel oxide as the new products was confirmed by XRD analysis. SEM imaging revealed the uniform and spherical morphology of the nanoparticles, which exhibited a remarkably narrow size distribution with an average diameter of 20 to 22 nm, highlighting their exceptional precision.
{"title":"Synthesis and Characterization of CuO and NiO Nanoparticles Derived from Schiff Base Complexes","authors":"A. Bader","doi":"10.26554/sti.2024.9.1.103-112","DOIUrl":"https://doi.org/10.26554/sti.2024.9.1.103-112","url":null,"abstract":"This study reports the synthesizes of such as copper oxide (CuO) and nickel oxide (NiO) nanoparticles (NPs) by thermal decompositions of Schiff base complexes and their physical characterization. A polydentate Schiff base ligand, (E)-2-(((2-chlorobenzyl)imino)methyl)phenol (CIMP), was synthesized by condensing 2-chlorobenzylamine and 2-hydroxybenzaldehyde. The ligand was identified by melting point, FT-IR, UV-Vis, and (1H and 13C NMR) spectroscopy. Cu(II) and Ni(II) complexes were prepared by reacting CIMP with the corresponding molar ratio in a 1:1 (metal: ligand). The complexes (Com1 and Com2) were characterized by melting point, FT-IR, and UV-Vis spectroscopy. The FT-IR spectra of the (Com1 and Com2) showed that the deprotonated CIMP ligand coordinated to the Ni(II) and Cu(II) metal ions through the azomethine nitrogen, aryl chloride, chlorine, and phenolic oxygen atoms. To determine the crystalline structure of the synthesized products, X-ray powder diffraction (XRD) and scanning electron microscopy (SEM) techniques were employed. The formation of copper oxide and nickel oxide as the new products was confirmed by XRD analysis. SEM imaging revealed the uniform and spherical morphology of the nanoparticles, which exhibited a remarkably narrow size distribution with an average diameter of 20 to 22 nm, highlighting their exceptional precision.","PeriodicalId":21644,"journal":{"name":"Science and Technology Indonesia","volume":"33 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139607675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-22DOI: 10.26554/sti.2024.9.1.77-85
Sivakumar Thirupathi, Nirmala Thamaraiselvan
Tridiagonal interval matrices are relevant in diverse applications, especially in dealing with parameter estimation, optimization and circuit analysis uncertainties. This research paper aims to improve the computational efficiency of obtaining the inverse of a general tridiagonal interval matrix. This matrix is pivotal in electric circuit analysis. We achieve this by employing interval arithmetic operations in the LU decomposition process, enabling effective handling of circuit parameter uncertainties. This approach generates an inverse interval matrix that addresses uncertainties in circuit analyses.
三对角区间矩阵的应用多种多样，特别是在处理参数估计、优化和电路分析不确定性方面。本研究论文旨在提高一般三对角区间矩阵求逆的计算效率。该矩阵在电路分析中至关重要。为此，我们在 LU 分解过程中采用了区间算术运算，从而有效地处理了电路参数的不确定性。这种方法生成的逆区间矩阵可解决电路分析中的不确定性问题。
{"title":"Tridiagonal Interval Matrix: Exploring New Perspectives and Application","authors":"Sivakumar Thirupathi, Nirmala Thamaraiselvan","doi":"10.26554/sti.2024.9.1.77-85","DOIUrl":"https://doi.org/10.26554/sti.2024.9.1.77-85","url":null,"abstract":"Tridiagonal interval matrices are relevant in diverse applications, especially in dealing with parameter estimation, optimization and circuit analysis uncertainties. This research paper aims to improve the computational efficiency of obtaining the inverse of a general tridiagonal interval matrix. This matrix is pivotal in electric circuit analysis. We achieve this by employing interval arithmetic operations in the LU decomposition process, enabling effective handling of circuit parameter uncertainties. This approach generates an inverse interval matrix that addresses uncertainties in circuit analyses.","PeriodicalId":21644,"journal":{"name":"Science and Technology Indonesia","volume":"9 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139608508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-22DOI: 10.26554/sti.2024.9.1.86-93
Muhammad Anas, Mardiana Napirah, Wa Ode Sitti Ilmawati, Husein Husein, Amiruddin Takda, Like Herawati, Ima Ima, Karmila Sari
Activated carbon or activated charcoal is one of the best materials that can be used as a constituent of CDI electrodes, not only because of its various advantageous properties but also because it can be sourced abundantly from plant waste. This research aims to determine the effect of the thickness of the candlenut shell activated charcoal electrode and the particle size of the activated carbon used on the capacitive deionization (CDI) performance in seawater desalination. Candlenut shell-based activated charcoal is obtained in three stages, namely preparation, carbonization, and activation. The carbonization stage was done by using a pyrolysis reactor at a temperature of 400°C for 8 hours. The activation was done with the activator of H3PO4 67%. The variation of thickness was 6 mm, 8 mm, 10 mm, and 15 mm while the variation of particle size was 60 mesh, 80 mesh, 100 mesh, and 200 mesh. The results showed that the higher capacitance was obtained with the thinner electrodes, where the best value was the thinnest electrode, 6 mm, which produced the highest capacitance, 122.96 nF. For the desalination of seawater, it is shown that the finest particle/smallest particle size will result in the best desalination performance, where 200 mesh particle size will result in the decrease of salinity from 34% to 4%. That is 88.23% decrease in salinity. Therefore, the using of candlenut shell-based activated carbon as the electrode in CDI is proven to be able to obtain good performance in seawater desalination.
{"title":"The Utilization of Candlenut Shell-Based Activated Charcoal as the Electrode of Capacitive Deionization (CDI) for Seawater Desalination","authors":"Muhammad Anas, Mardiana Napirah, Wa Ode Sitti Ilmawati, Husein Husein, Amiruddin Takda, Like Herawati, Ima Ima, Karmila Sari","doi":"10.26554/sti.2024.9.1.86-93","DOIUrl":"https://doi.org/10.26554/sti.2024.9.1.86-93","url":null,"abstract":"Activated carbon or activated charcoal is one of the best materials that can be used as a constituent of CDI electrodes, not only because of its various advantageous properties but also because it can be sourced abundantly from plant waste. This research aims to determine the effect of the thickness of the candlenut shell activated charcoal electrode and the particle size of the activated carbon used on the capacitive deionization (CDI) performance in seawater desalination. Candlenut shell-based activated charcoal is obtained in three stages, namely preparation, carbonization, and activation. The carbonization stage was done by using a pyrolysis reactor at a temperature of 400°C for 8 hours. The activation was done with the activator of H3PO4 67%. The variation of thickness was 6 mm, 8 mm, 10 mm, and 15 mm while the variation of particle size was 60 mesh, 80 mesh, 100 mesh, and 200 mesh. The results showed that the higher capacitance was obtained with the thinner electrodes, where the best value was the thinnest electrode, 6 mm, which produced the highest capacitance, 122.96 nF. For the desalination of seawater, it is shown that the finest particle/smallest particle size will result in the best desalination performance, where 200 mesh particle size will result in the decrease of salinity from 34% to 4%. That is 88.23% decrease in salinity. Therefore, the using of candlenut shell-based activated carbon as the electrode in CDI is proven to be able to obtain good performance in seawater desalination.","PeriodicalId":21644,"journal":{"name":"Science and Technology Indonesia","volume":"42 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139608610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-22DOI: 10.26554/sti.2024.9.1.167-172
S. Yudha S., Eka Angasa, Muhamad Alvin Reagen, Mohsin Kazi
The intriguing pursuit of environmentally friendly solvents with tailored properties for diverse applications is a focal point of numerous studies, encompassing precursor selection, thorough characterization, and the exploration of potential applications. The study aims to assess the physicochemical properties and antimicrobial activity of deep eutectic solvents (DES) produced from N,N-dimethyl urea (DMU) and citric acid (CA), highlighting differences from their individual precursors. Various mass ratio variations of (DMU, solid) and (CA, solid) (DMU:CA = 1.0:1.0; 1.0:1.5; 1.0:2.0; 2.0: 1.0; 1.5:1.0) have been tested to make DES solvents through the melt process. Both types of blends generally melt at a temperature of 80°C. The overall liquid resulting from the melting of solids was generally clear in color. Molecular analysis using an infrared spectrophotometer showed some insignificant shifts from one product to another, compared with DMU and CA as precursors. Likewise, analysis using a UV–Vis spectrophotometer, when the entire sample was dissolved in demineralized water (2 mg/mL), showed no difference in the spectrum. In addition, functional group analysis using a spectrophotometer showed some minor changes, mainly shifts in peaks due to changes in the DMU:CA ratio. This may be due to the interaction of the hydrogen donor and the hydrogen acceptor in DES. All samples showed absorption peaks in the ultraviolet region of 202-210 nm. The resulting DES application showed growth inhibitory activity for Staphylococcus aureus and Escherichia coli bacteria in all products produced. The same analysis of the two types of precursors used showed that only CA had activity, but DMU did not have similar activity.
为不同应用领域量身定制具有特定特性的环境友好型溶剂是众多研究的焦点，其中包括前体选择、彻底表征和潜在应用领域的探索。本研究旨在评估由 N,N-二甲基脲（DMU）和柠檬酸（CA）制备的深共晶溶剂（DES）的理化性质和抗菌活性，突出其与单个前体的差异。我们测试了（DMU，固体）和（CA，固体）的各种质量比变化（DMU:CA = 1.0:1.0；1.0:1.5；1.0:2.0；2.0:1.0；1.5:1.0），以通过熔融工艺制造 DES 溶剂。这两种混合物一般都在 80°C 的温度下熔化。固体熔化后形成的液体一般呈透明色。使用红外线分光光度计进行的分子分析表明，与作为前体的 DMU 和 CA 相比，从一种产品到另一种产品之间存在一些不明显的变化。同样，使用紫外可见分光光度计进行分析，当整个样品溶解在去矿物质水中（2 毫克/毫升）时，光谱显示没有差异。此外，使用分光光度计进行的官能团分析显示出一些微小的变化，主要是由于 DMU:CA 比例的变化导致的峰值移动。这可能是由于 DES 中氢供体和氢受体的相互作用造成的。所有样品都在 202-210 纳米的紫外线区域出现了吸收峰。应用 DES 生产的所有产品都显示出对金黄色葡萄球菌和大肠杆菌的生长抑制活性。对所使用的两种前体进行的相同分析表明，只有 CA 具有活性，而 DMU 没有类似的活性。
{"title":"Molecular Spectroscopic (FTIR and UV-Vis) Analysis and In Vitro Antibacterial Investigation of a Deep Eutectic Solvent of N,N-Dimethyl Urea-Citric Acid","authors":"S. Yudha S., Eka Angasa, Muhamad Alvin Reagen, Mohsin Kazi","doi":"10.26554/sti.2024.9.1.167-172","DOIUrl":"https://doi.org/10.26554/sti.2024.9.1.167-172","url":null,"abstract":"The intriguing pursuit of environmentally friendly solvents with tailored properties for diverse applications is a focal point of numerous studies, encompassing precursor selection, thorough characterization, and the exploration of potential applications. The study aims to assess the physicochemical properties and antimicrobial activity of deep eutectic solvents (DES) produced from N,N-dimethyl urea (DMU) and citric acid (CA), highlighting differences from their individual precursors. Various mass ratio variations of (DMU, solid) and (CA, solid) (DMU:CA = 1.0:1.0; 1.0:1.5; 1.0:2.0; 2.0: 1.0; 1.5:1.0) have been tested to make DES solvents through the melt process. Both types of blends generally melt at a temperature of 80°C. The overall liquid resulting from the melting of solids was generally clear in color. Molecular analysis using an infrared spectrophotometer showed some insignificant shifts from one product to another, compared with DMU and CA as precursors. Likewise, analysis using a UV–Vis spectrophotometer, when the entire sample was dissolved in demineralized water (2 mg/mL), showed no difference in the spectrum. In addition, functional group analysis using a spectrophotometer showed some minor changes, mainly shifts in peaks due to changes in the DMU:CA ratio. This may be due to the interaction of the hydrogen donor and the hydrogen acceptor in DES. All samples showed absorption peaks in the ultraviolet region of 202-210 nm. The resulting DES application showed growth inhibitory activity for Staphylococcus aureus and Escherichia coli bacteria in all products produced. The same analysis of the two types of precursors used showed that only CA had activity, but DMU did not have similar activity.","PeriodicalId":21644,"journal":{"name":"Science and Technology Indonesia","volume":"11 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139609247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-22DOI: 10.26554/sti.2024.9.1.69-76
E. Elfita, Rian Oktiansyah, M. Mardiyanto, Arum Setiawan, H. Widjajanti
Endophytic fungi extracts have various biological and pharmacological activities as natural antioxidants which have the potential to be developed in the pharmaceutical. Drugs made from natural substances frequently work best when they are present in large quantities. This may result in unfavorable side effects from using more of one substance at a time. This limitation can be overcome by using a combination of the extracts/pure compounds that allow synergistic interactions with strong antioxidant properties at fairly low concentrations. The purpose of this research was to determine the combined effect of endophytic fungi extracts and its pure compounds on their antioxidant activity. This research was initiated by rejuvenating eight selected endophytic fungal isolates from Sungkai leaves and morphological characterization was carried out. Each fungus was cultivated in PDB medium for 4 weeks under statistical conditions. Ethyl acetate was used to extract the endophytic fungi’s liquid culture, which was then evaporated. Each endophytic fungal extract (PD1-PD8) and their five pure compounds were tested for antioxidant activity by the DPPH method. Then a combination of two and three extracts was carried out with a ratio of 1:1. The results show that the interaction of the mixture of endophytic fungi extracts and their pure compounds can be classified as synergistic (combined effect of the extracts > individual effects), additive (combined effect of the extracts = individual effect), and nothing is antagonistic (combined effect of the extracts < individual effects). The best combination in this study was PD4+PD5+PD6 (1:1:1) which could be used as a formula for further research into in vivo immunostimulant tests. Another conclusion from this research is that the pure compounds contained in the extracts have lower antioxidant activity than the extracts and do not have a synergistic effect on the combination.
{"title":"Combination Effect of Extracts and Pure Compounds of Endophytic Fungi Isolated from Sungkai (Peronema canescens) Leaves on Antioxidant Activity","authors":"E. Elfita, Rian Oktiansyah, M. Mardiyanto, Arum Setiawan, H. Widjajanti","doi":"10.26554/sti.2024.9.1.69-76","DOIUrl":"https://doi.org/10.26554/sti.2024.9.1.69-76","url":null,"abstract":"Endophytic fungi extracts have various biological and pharmacological activities as natural antioxidants which have the potential to be developed in the pharmaceutical. Drugs made from natural substances frequently work best when they are present in large quantities. This may result in unfavorable side effects from using more of one substance at a time. This limitation can be overcome by using a combination of the extracts/pure compounds that allow synergistic interactions with strong antioxidant properties at fairly low concentrations. The purpose of this research was to determine the combined effect of endophytic fungi extracts and its pure compounds on their antioxidant activity. This research was initiated by rejuvenating eight selected endophytic fungal isolates from Sungkai leaves and morphological characterization was carried out. Each fungus was cultivated in PDB medium for 4 weeks under statistical conditions. Ethyl acetate was used to extract the endophytic fungi’s liquid culture, which was then evaporated. Each endophytic fungal extract (PD1-PD8) and their five pure compounds were tested for antioxidant activity by the DPPH method. Then a combination of two and three extracts was carried out with a ratio of 1:1. The results show that the interaction of the mixture of endophytic fungi extracts and their pure compounds can be classified as synergistic (combined effect of the extracts > individual effects), additive (combined effect of the extracts = individual effect), and nothing is antagonistic (combined effect of the extracts < individual effects). The best combination in this study was PD4+PD5+PD6 (1:1:1) which could be used as a formula for further research into in vivo immunostimulant tests. Another conclusion from this research is that the pure compounds contained in the extracts have lower antioxidant activity than the extracts and do not have a synergistic effect on the combination.","PeriodicalId":21644,"journal":{"name":"Science and Technology Indonesia","volume":"92 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139606476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-22DOI: 10.26554/sti.2024.9.1.156-166
N. Palapa, Zaqiya Artha Zahara, R. Mohadi, I. Royani, A. Lesbani
Elevated concentrations of dyes in water have a significant impact on both the aquatic ecosystem and human well-being. The adsorption approach, which is cost-effective and simple to use, was chosen for color treatment. The adsorbents used in this study were Modified Layered Double Hydroxides (LDHs) and Magnetite Biochar (MBC). To prepare the Ni-Al/MBC composites, a technique called coprecipitation and hydrothermal was employed. The successful preparation of these composites was confirmed through the use of characterization tests including X-Ray Diffraction (XRD), Fourier Transform – Infra Red (FT-IR), Brunauer Emmet Teller (BET), and Vibrating Sample Magnometer (VSM). The study focused on analyzing the kinetics, isotherms, and thermodynamics of adsorption in order to anticipate the mechanism of Methyl Orange (MO) adsorption. Additionally, the regeneration process was investigated to assess the adsorbent's ability for repeated usage. The percentage of Ni-Al/MBC adsorbed during the first to fifth regeneration cycles was 86.940%, 82.545%, 70.752%, 56.244%, and 34.503% respectively. The duration of contact was 70 minutes, as determined by the Pseudo Second Order (PSO) equation, with an adsorption rate of 0.0030 g/mg.min. The Langmuir equation indicated a maximum adsorption capacity of 45.455 mg/g.
{"title":"High Performance of Ni-Al/magnetite Biochar for Methyl Orange Removal in Aqueous Solution","authors":"N. Palapa, Zaqiya Artha Zahara, R. Mohadi, I. Royani, A. Lesbani","doi":"10.26554/sti.2024.9.1.156-166","DOIUrl":"https://doi.org/10.26554/sti.2024.9.1.156-166","url":null,"abstract":"Elevated concentrations of dyes in water have a significant impact on both the aquatic ecosystem and human well-being. The adsorption approach, which is cost-effective and simple to use, was chosen for color treatment. The adsorbents used in this study were Modified Layered Double Hydroxides (LDHs) and Magnetite Biochar (MBC). To prepare the Ni-Al/MBC composites, a technique called coprecipitation and hydrothermal was employed. The successful preparation of these composites was confirmed through the use of characterization tests including X-Ray Diffraction (XRD), Fourier Transform – Infra Red (FT-IR), Brunauer Emmet Teller (BET), and Vibrating Sample Magnometer (VSM). The study focused on analyzing the kinetics, isotherms, and thermodynamics of adsorption in order to anticipate the mechanism of Methyl Orange (MO) adsorption. Additionally, the regeneration process was investigated to assess the adsorbent's ability for repeated usage. The percentage of Ni-Al/MBC adsorbed during the first to fifth regeneration cycles was 86.940%, 82.545%, 70.752%, 56.244%, and 34.503% respectively. The duration of contact was 70 minutes, as determined by the Pseudo Second Order (PSO) equation, with an adsorption rate of 0.0030 g/mg.min. The Langmuir equation indicated a maximum adsorption capacity of 45.455 mg/g.","PeriodicalId":21644,"journal":{"name":"Science and Technology Indonesia","volume":"35 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139607781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-22DOI: 10.26554/sti.2024.9.1.120-128
Kiattisak Rattanadilok Na Phuket, Tussanee Srimachai, Saowarod Luanunkarb, S. O-thong
This experiment was conducted to decide the impact of molasses and glycerol waste on upgraded methane production in anaerobicco-digestion with distillery wastewater. Co-substrates used for biogas production in the anaerobic co-fermentation process ofdistillery wastewater (DW) were molasses (ML) and glycerol waste (GW). The co-substrate concentration in all batch experimentsvaried between 1% and 5% (v/v). To study the efficiency of biogas production, the optimal ratio was chosen for operation in thePFR continuous reactor. Optimization results indicated that anaerobic co-digestion of DW with 5% GW and 1% ML could improvebiogas quality and quantity. HRT for 30 days allowed R2 (95% DW: 5% GW) to produce maximum methane production per 11 m3CH4/m3mixed wastewater, followed by R1 (99% DW: 1%). ML) 6 m3CH4/m3mixed wastewater and control (100% DW) could onlyproduce 2.7 m3CH4/m3mixed wastewater methane. As co-substrates, GW and ML can be balanced to coordinate the C/N ratio andpH of DW. In particular, the C/N ratio of the mixed sewage can be balanced, and the concentration of ammonia nitrogen within ananaerobic digestion tank can be diluted. Therefore, GW can be used as an optimal co-substrate as it improves the C/N ratio, dilutestoxic compounds within DW, and provides lower prices, thus increasing the potential for methanogenesis within DW affected toincrease biogas production.
{"title":"Enhanced Efficiency for Biogas Production from Distillery Wastewater as Mixed with Molasses and Glycerol Waste in the Anaerobic Co-Digestion","authors":"Kiattisak Rattanadilok Na Phuket, Tussanee Srimachai, Saowarod Luanunkarb, S. O-thong","doi":"10.26554/sti.2024.9.1.120-128","DOIUrl":"https://doi.org/10.26554/sti.2024.9.1.120-128","url":null,"abstract":"This experiment was conducted to decide the impact of molasses and glycerol waste on upgraded methane production in anaerobicco-digestion with distillery wastewater. Co-substrates used for biogas production in the anaerobic co-fermentation process ofdistillery wastewater (DW) were molasses (ML) and glycerol waste (GW). The co-substrate concentration in all batch experimentsvaried between 1% and 5% (v/v). To study the efficiency of biogas production, the optimal ratio was chosen for operation in thePFR continuous reactor. Optimization results indicated that anaerobic co-digestion of DW with 5% GW and 1% ML could improvebiogas quality and quantity. HRT for 30 days allowed R2 (95% DW: 5% GW) to produce maximum methane production per 11 m3CH4/m3mixed wastewater, followed by R1 (99% DW: 1%). ML) 6 m3CH4/m3mixed wastewater and control (100% DW) could onlyproduce 2.7 m3CH4/m3mixed wastewater methane. As co-substrates, GW and ML can be balanced to coordinate the C/N ratio andpH of DW. In particular, the C/N ratio of the mixed sewage can be balanced, and the concentration of ammonia nitrogen within ananaerobic digestion tank can be diluted. Therefore, GW can be used as an optimal co-substrate as it improves the C/N ratio, dilutestoxic compounds within DW, and provides lower prices, thus increasing the potential for methanogenesis within DW affected toincrease biogas production.","PeriodicalId":21644,"journal":{"name":"Science and Technology Indonesia","volume":"24 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139608873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-22DOI: 10.26554/sti.2024.9.1.28-35
Yosirham Abdu Salam, L. Komariah, F. Hadiah, S. Arita
Biodiesel production is generally catalyzed by potassium methylate or sodium methylate catalysts based on KOH and NaOH and these catalysts are still imported. The search for a cheap and effective catalyst continues to be carried out by researchers. One of the catalyst support materials currently in use involves impregnating K2CO3 with various substances, resulting in a heterogeneous catalyst. In this study, it was tried to use K2CO3 dissolved in methanol to produce a homogeneous potassium methylate catalyst. Potassium methylate-based homogeneous catalyst K2CO3-methanol is proven to have a very high function in the transesterification reaction of Refined Bleached Deodorized Palm Oil (RBDPO) into biodiesel, this is evidenced by the use of a catalyst percentage of 2% w and 30% w methanol to the weight of RBDPO resulting in an acid content in biodiesel of only 0.12% and a total glycerol of 0.124% in reaction time 3 hours, with the purity of the methyl ester in biodiesel reaching 98.80%. Meanwhile, for the calculation of homogeneous reaction kinetics, a reaction rate equation is produced where the order of the RBDPO transesterification reaction is order 2 (two) and the reaction rate constant is 0.0044.
{"title":"Kinetics of Homogeneous Reaction of Potassium Methoxide Based on K2CO3 Catalyst in Transesterification of RBDPO to Biodiesel","authors":"Yosirham Abdu Salam, L. Komariah, F. Hadiah, S. Arita","doi":"10.26554/sti.2024.9.1.28-35","DOIUrl":"https://doi.org/10.26554/sti.2024.9.1.28-35","url":null,"abstract":"Biodiesel production is generally catalyzed by potassium methylate or sodium methylate catalysts based on KOH and NaOH and these catalysts are still imported. The search for a cheap and effective catalyst continues to be carried out by researchers. One of the catalyst support materials currently in use involves impregnating K2CO3 with various substances, resulting in a heterogeneous catalyst. In this study, it was tried to use K2CO3 dissolved in methanol to produce a homogeneous potassium methylate catalyst. Potassium methylate-based homogeneous catalyst K2CO3-methanol is proven to have a very high function in the transesterification reaction of Refined Bleached Deodorized Palm Oil (RBDPO) into biodiesel, this is evidenced by the use of a catalyst percentage of 2% w and 30% w methanol to the weight of RBDPO resulting in an acid content in biodiesel of only 0.12% and a total glycerol of 0.124% in reaction time 3 hours, with the purity of the methyl ester in biodiesel reaching 98.80%. Meanwhile, for the calculation of homogeneous reaction kinetics, a reaction rate equation is produced where the order of the RBDPO transesterification reaction is order 2 (two) and the reaction rate constant is 0.0044.","PeriodicalId":21644,"journal":{"name":"Science and Technology Indonesia","volume":"83 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139606205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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