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Possible Therapeutic Role of Novel Vanadium Complexes in Diabetes MellitusAnimal Models 新型钒配合物在糖尿病动物模型中的可能治疗作用
Pub Date : 2018-12-01 DOI: 10.21608/sjdfs.2018.194811
M. Diab, B. Hassan, H. El-mezayen
Diabetic mellitus is a group of metabolic disorders in which there are high blood sugar levels over a prolonged period, diabetes can causes many complications. The trace element vanadium has unclear biological functions. Vanadate, an oxidized form of vanadium, appears to have an insulinlike action, the effect of vanadate on blood glucose was assessed in male Wistar rats after they were made diabetic with Streptozotocin (STZ). The animals were fasted overnight and a single intraperitoneal injection of a freshly prepared solution of STZ (55 mg/Kg b.wt) in 0.1 M cold citrate buffer (PH 4.5) was given to induce diabetes. The animals were allowed to access to 5 per cent glucose solution overnight, to prevent total hypoglycemia, induced by STZ by massive pancreatic insulin release. The animals were considered as diabetic, if their blood glucose values were above 250 mg/dL on the third day (72 hours) after STZ injection. The treatment was started on the fourth day after STZ injection and the day was considered as first day of treatment. The treatment was continued for 15 days. Diabetes causes disturbance in liver and kidney functions and causes hyperlipidemia also decreased the antioxidant activity; after the treatment with the two novel vanadium complexes , all functions of liver (Alanine transferase, Aspartate transferase and total protein) and kidney functions ( Creatinine and urea ) were improved. Also, lipid profile (total cholesterol and Triglycerides) level decreased and the activity of antioxidant enzymes (Superoxidedismutase, Glutathione peroxidase, Glutathione reductase and Malonodialdhyde)
糖尿病是一种长期高血糖的代谢性疾病,糖尿病可引起许多并发症。微量元素钒的生物学功能尚不清楚。钒酸盐是钒的一种氧化形式,似乎具有类似胰岛素的作用,在用链脲佐菌素(STZ)致糖尿病的雄性Wistar大鼠中评估了钒酸盐对血糖的影响。动物禁食一夜,并在0.1 M冷柠檬酸缓冲液(PH 4.5)中单次腹腔注射新鲜制备的STZ溶液(55 mg/Kg b.wt)以诱导糖尿病。这些动物被允许使用5%的葡萄糖溶液过夜,以防止STZ通过大量胰腺胰岛素释放引起的全面低血糖。注射STZ后第3天(72小时)血糖值高于250 mg/dL即为糖尿病。注射STZ后第4天开始治疗,当日作为治疗第1天。治疗持续15天。糖尿病引起肝肾功能紊乱,引起高脂血症,抗氧化活性下降;两种新型钒配合物处理后,肝脏(丙氨酸转移酶、天冬氨酸转移酶和总蛋白)和肾脏(肌酐和尿素)功能均有改善。脂质谱(总胆固醇和甘油三酯)水平下降,抗氧化酶(超氧化物歧化酶、谷胱甘肽过氧化物酶、谷胱甘肽还原酶和丙二醛)活性下降。
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引用次数: 1
Ion selective carbon paste electrodes based on ion pair formation for determination of Tetra-n-butyl ammonium bromide 基于离子对形成的离子选择碳糊电极测定四正丁基溴化铵
Pub Date : 2018-12-01 DOI: 10.21608/sjdfs.2018.194806
Sally E.A. El-Ashery, Eman Y.Z. Frag, Mohamed G. Moussa, G. Mohamed
In this study, ion pairs formed between tetrabutyl ammonium bromide as surfactant and ion pairing agents as phosphotungetic acid (PTA), phosphomolybdic acid (PMA) and sodium tetraphenyl borate (NaTPB) have been used as electroactive materials for preparation of modified carbon paste electrodes (CPEs) selective to tetra-n-butyl ammonium bromide (TBAB) surfactant. Type and content of the different ion pairs on the performance of CPEs were studied. It was found that the best contents were, 15 mg of TBA-TPB (electrode I), 15 mg TBA-PTA (electrode II) and 6 mg TBA-PMA (electrode III) ion pairs, which gave the best Nernstian slope values of 59.41±0.31, 59.26±0.45 and 59.95±0.35 mVdecade, respectively. These fabricated electrodes exhibited suitable response to TBAB in a concentration range from 1.0x10 to 1.0x10 mol L with lower detection limit of 1.0x10 mol L. These fabricated electrodes exhibited fast response time of about 3, 7 and 6 s under working pH range of 3-8, 5-8 and 5-9 for electrodes I, II and III, respectively. The results obtained were satisfactory with excellent percentage recovery comparable and sometimes better than those obtained by other routine methods for the assay of TBAB surfactant.
本研究以表面活性剂四丁基溴化铵与离子对偶剂磷酸(PTA)、磷酸钼酸(PMA)和四苯基硼酸钠(NaTPB)之间形成的离子对为电活性材料,制备了选择性表面活性剂四正丁基溴化铵(TBAB)的改性碳糊电极(cpe)。研究了不同离子对类型和含量对CPEs性能的影响。结果表明,TBA-TPB(电极I)、TBA-PTA(电极II)和TBA-PMA(电极III)离子对的最佳含量分别为15 mg、15 mg和6 mg,其最佳能坡值分别为59.41±0.31、59.26±0.45和59.95±0.35 mVdecade。在TBAB浓度范围为1.0 × 10 ~ 1.0 × 10 mol L的条件下,电极ⅰ、电极ⅱ和电极ⅲ的检测限为1.0 × 10 mol L,电极ⅰ、电极ⅱ和电极ⅲ在3 ~ 8、5 ~ 8和5 ~ 9的工作pH范围内的响应时间分别为3、7和6 s。结果令人满意,回收率相当,有时甚至优于其他常规方法测定TBAB表面活性剂的结果。
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引用次数: 0
Analysis of Well Log Data for the Evaluation of Gas Sand Reservoir of Alam El-Bueib (AEB) Formation, 3G Member, Jade-8 Well, Jade Field, Matruh Basin, Egypt 埃及Matruh盆地Jade油田Jade-8井3G段Alam El-Bueib (AEB)组气砂岩储层评价测井数据分析
Pub Date : 2018-12-01 DOI: 10.21608/sjdfs.2018.194797
A. Basal, E. El-Twargy
The evaluation of gas reservoirs in Alam El Bueib has been dealt with through the interpretation of well log data. Alam El – Bueib (AEB) formation is monitored in Matruh basin at the Northern part of the Western Desert, Egypt encountered many gas producing reservoirs. Alam ElBueib – 3G (AEB – 3G) member was chosen for application of the presented techniques. The available well log data are in the form of Gamma Ray, Bit size, Caliper, Resistivity, Neutron, Density, Sonic and Photoelectric. The reservoir petrophysical parameters (Фeff, Sw, Bvw) besides mineralogical make up were evaluated for this member in JADE – 8 well. The gas zone represents a challenge for well log interpretation technique as they normally plotted above the standard porosity lines. A graphical technique was used to get Фeff in the zones on the ρb – ФN cross plot. The Sw Vs Ф was presented graphically on log – log plot for obtaining BVW constant lines. Line with slope unity discriminates between reservoir and non-reservoir for AEB – 3G member.
通过对测井资料的解释,对Alam El Bueib气藏进行了评价。Alam El - Bueib (AEB)地层位于埃及西部沙漠北部的Matruh盆地,遇到了许多产气储层。选择了Alam ElBueib - 3G (AEB - 3G)成员应用所提出的技术。可用的测井数据包括伽马射线、钻头尺寸、井径、电阻率、中子、密度、声波和光电。评价了JADE - 8井该段储层岩石物性参数(Фeff、Sw、Bvw)及矿物学组成。天然气层对于测井解释技术来说是一个挑战,因为它们通常绘制在标准孔隙度线之上。采用图形化技术求得ρb - ФN交叉图上各区域的Фeff。以对数-对数图的形式给出了Sw Vs Ф,以获得BVW常数线。以斜率统一线区分AEB - 3G区储层与非储层。
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引用次数: 0
Evaluation of Air Quality in Damietta Harbor Region 达米埃塔港区空气质量评价
Pub Date : 2017-12-01 DOI: 10.21608/sjdfs.2017.194768
MaieI El Gammal, Alia A. Shakour, M. Ibrahim, Omnya EI-Batrawy, W. Ali
Ship emissions in port areas are dispersed mainly concerns sulfur dioxide (SO2), nitrogen dioxide (NO2), particulate matter, ... etc., in the atmosphere, affecting air quality and jeopardizing people's health and quality of life. This study aims to assess air quality of Damietta Harbor Region. Implementing continuous monitoring of major air pollutants (NO2, SO2, CO, O3 and PM10) were found in Damietta harbor by using Ambient Air Quality Monitoring Station (AAQMS) from January 2013 to December 2015. According to the obtained results, the annual mean levels of NO2, SO2, CO and O3 in Damietta Port Area in 2013, 2014 and 2015 were 29.92, 41.50 and 29.12 μg/m of NO2, 26.68, 27.69 and 24.83 μg/m of SO2 , 5.31, 2.29 and 6.23 mg/m of CO and 33.10, 41.00 and 39.43 μg/m of O3, respectively. These results did not exceed the AQL as stipulated in the Egyptian Environmental Law 4/94 and its executive regulations (80, 60 μg/m) for NO2 and SO2, and (10 mg/m for 8 hrs.) for CO, and (120 μg/m for 8 hrs.) for O3. Whereas, the annual mean levels of PM10 in Damietta Port Area were 83.56 and 72.32 μg/m, in 2013 and 2015 respectively, found higher than AQL as stipulated in the Egyptian Environmental Law 4/94 and its executive regulations (70μg/m).
港区船舶排放分散主要涉及二氧化硫(SO2)、二氧化氮(NO2)、颗粒物、…等,在大气中,影响空气质量,危害人们的健康和生活质量。本研究旨在评估达米埃塔港区的空气质素。2013年1月至2015年12月,利用环境空气质量监测站(AAQMS)对Damietta港主要空气污染物(NO2、SO2、CO、O3和PM10)进行了连续监测。结果表明,2013年、2014年和2015年达米埃塔港区NO2、SO2、CO和O3年平均浓度分别为NO2 29.92、41.50和29.12 μg/m, SO2 26.68、27.69和24.83 μg/m, CO 5.31、2.29和6.23 mg/m, O3 33.10、41.00和39.43 μg/m。这些结果没有超过埃及环境法4/94及其执行法规规定的AQL (NO2和SO2 80,60 μg/m), CO (10 mg/m, 8小时)和O3 (120 μg/m, 8小时)。而达米埃塔港区2013年和2015年的年均PM10水平分别为83.56和72.32 μg/m,高于埃及环境法4/94及其行政法规规定的AQL (70μg/m)。
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引用次数: 0
Protective and Therapeutic Effects of Moringa Oleifera Against Toxicity of Lead Chloride 辣木对氯化铅毒性的保护和治疗作用
Pub Date : 2017-12-01 DOI: 10.21608/sjdfs.2018.194790
K. Elbakry, N. Elarabany, S. Behery
The present study aimed to evaluate the protective and therapeutic effects of M. oleifera leaves against toxicity induced by PbCl2 in albino male rats. Thirty-six albino rats weighing about 182.8 g were divided into 6 groups each of 6 rats. Control group, left without treatment. The PbCl 2 group treated orally with 200 mg PbCl 2 daily for 30 days. The M. oleifera group treated orally with 200 mg M. oleifera daily for 30 days. PbCl 2 + M. oleifera group (200 mg PbCl 2 + 200 mg M. oleifera ). Therapeutic group (200 mg PbCl 2 followed by 200 mg M. oleifera ) and protective group (200 mg M. oleifera followed by 200 mg PbCl 2 ). At the end of the experiment, both kidney and liver function tests were assayed as well as catalase and SOD enzymes activity and MDA level. The activity of ALT and the levels of bilirubin, urea, creatinine, cholesterol, ammonia, urea and triglycerides were elevated after lead administration compared with the control and protective groups (p<0.05) but the level of albumin of the same group was decreased compared with the control group. In protective group, the level of MDA was significantly decrease compared with that of the lead group. On the other hand, the activities of SOD and catalase were significantly increase in the protective group as well as other treated groups compared with the control group (p<0.05). In conclusion, treatment with M. oleifera leaves can protect liver and kidney against lead toxicity.
本研究旨在探讨油松叶对PbCl2对白化雄性大鼠毒性的保护和治疗作用。将36只体重约182.8 g的白化大鼠分为6组,每组6只。对照组,不作任何处理。pbcl2组每日口服200mg,连用30天。油桐组每日口服油桐200 mg,连用30 d。PbCl 2 + M. oleifera组(200 mg PbCl 2 + 200 mg M. oleifera)。治疗组(200 mg pbcl2 + 200 mg油橄榄)和保护组(200 mg油橄榄+ 200 mg pbcl2)。实验结束时测定大鼠肾功能、肝功能,过氧化氢酶、超氧化物歧化酶活性及丙二醛水平。与对照组和保护组相比,给铅后小鼠ALT活性、胆红素、尿素、肌酐、胆固醇、氨、尿素和甘油三酯水平均升高(p<0.05),白蛋白水平则降低(p<0.05)。与铅组相比,保护组MDA水平明显降低。另一方面,与对照组相比,保护组和其他处理组的SOD和过氧化氢酶活性显著升高(p<0.05)。综上所述,油桐叶处理具有保护肝脏和肾脏免受铅中毒的作用。
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引用次数: 0
Environmental Toxicity of Sodium Fluoride on Fertility in Male Rats and the Protective Role of Inulin Extract 氟化钠对雄性大鼠生育能力的环境毒性及菊粉提取物的保护作用
Pub Date : 2017-12-01 DOI: 10.21608/sjdfs.2017.194776
A. Abou-EI Naga, Mahmoud Ibrahim, Maie EI Gammal, Omnya EI-Batrawy, M. Abbas
The aim of this work to investigate the effects of sodium fluoride (NaF) on male reproductive function and evaluate the protective effects of inulin against sodium fluoride (NaF) induced male reproductive toxicity in adult male albino rats. In this study, forty adult male albino rats were used, they were divided randomly into four groups: a control group (1), which was given distilled water, and three treatment groups, which was received daily oral doses of; sodium fluoride (10 mg/kg.b.w.) of group (2), inulin (10 mg/kg) + sodium fluoride (10 mg/kg) of group (3), and inulin (10 mg/kg.b.w.) of group (4) for 3 months. The sperm quality, complete sperm motility, morphology and sperm count were assessed. The levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), testosterone (T), and progesterone (P) were used as indicators of male reproductive health. The whole testis tissues isolated was used for histopathological studies. The results showed that sodium fluoride induces severe toxic changes in the male reproductive system and inulin could provide these toxic effects.
本研究旨在探讨氟化钠(NaF)对雄性生殖功能的影响,并评价菊粉对氟化钠(NaF)诱导的成年雄性白化大鼠雄性生殖毒性的保护作用。本研究选用成年雄性白化病大鼠40只,随机分为4组:对照组(1)给予蒸馏水;治疗组(3)给予每日口服剂量的;组(2)氟化钠(10毫克/公斤体重),组(3)菊粉(10毫克/公斤)+氟化钠(10毫克/公斤体重),组(4)菊粉(10毫克/公斤体重),为期3个月。评估精子质量、全精子活力、形态和精子数量。以卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、睾酮(T)、孕酮(P)水平作为男性生殖健康的指标。分离的整个睾丸组织用于组织病理学研究。结果表明,氟化钠可引起雄性生殖系统的严重毒性变化,菊粉可提供这种毒性作用。
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引用次数: 0
Biosynthesis of silver nanoparticles by Enterobacter sp. and their antifungal activity against the phytopathogenic fungus Fusarium oxysporum f. sp. lycopersici 银纳米颗粒在肠杆菌中的合成及其对番茄枯萎菌的抑菌活性
Pub Date : 2017-12-01 DOI: 10.21608/sjdfs.2017.194771
M. El-Zahed, M. Nour El-Dein, M. Abou-Dobara, Z. Baka
This study was concerned with the isolation of bacterial strains from different water sources. Among these strains; Enterobacter sp. exhibited extracellularly biosynthesized silver nanoparticles with good monodispersity. Enterobacter sp. has produced extremely stable nanoparticles within 72 hrs at 35°C in dark conditions. These nanoparticles are characterized by UV–vis spectrophotometer, transmission electron microscopy, Zeta potential analyzer, and size distribution by volume. Enterobacter sp. synthesized 9.45-17.15 nm sized spherical shaped silver nanoparticles. The presence and binding of stabilized proteins with nanoparticles were confirmed by the zeta size distribution by volume. Our study demonstrates that silver nanoparticles are potent inhibitors of the plant pathogenic fungus, Fusarium oxysporum f. sp. lycopersici.
本研究对不同水源中细菌的分离进行了研究。在这些菌株中;肠杆菌表现出细胞外生物合成的银纳米颗粒具有良好的单分散性。肠杆菌在35°C的黑暗条件下,在72小时内产生了非常稳定的纳米颗粒。采用紫外-可见分光光度计、透射电子显微镜、Zeta电位分析仪和体积大小分布对纳米颗粒进行了表征。Enterobacter sp.合成了9.45-17.15 nm大小的球形银纳米颗粒。通过zeta大小的体积分布证实了稳定蛋白与纳米颗粒的存在和结合。我们的研究表明,银纳米颗粒是植物病原真菌番茄枯萎病的有效抑制剂。
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引用次数: 0
Application of Seismic Attributes for Detecting Different Geologic Features within Kafr El Sheikh Formation, Temsah Concession, Nile Delta Basin 地震属性在尼罗河三角洲盆地Temsah特许权Kafr El Sheikh组不同地质特征探测中的应用
Pub Date : 2017-12-01 DOI: 10.21608/sjdfs.2017.194770
Mohammad Abdelfattah Sarhan, M. Safa
The seismic attributes help the interpreter to extract more information from conventional seismic data to support the geologic interpretations for the examined study area. The present work has revealed that the best seismic attributes which can be used to display the buried channels include, envelope, RMS amplitude, sweetness, chaos and spectral decomposition attributes. However, structural dip and variance attributes enhance the appearance of faults and fractures on the seismic sections. .
地震属性有助于解释人员从常规地震数据中提取更多信息,以支持研究区域的地质解释。研究表明,可以用来显示埋地通道的最佳地震属性包括包络、均方根振幅、甜度、混沌和谱分解属性。然而,构造倾角和变异属性增强了断层和裂缝在地震剖面上的表现。
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引用次数: 5
Responses of Six Oil Sunflower (Helianthus annuus L) Genotypes to Post-Anthesis Water Deficit 6种油葵基因型对花后水分亏缺的响应
Pub Date : 2017-12-01 DOI: 10.21608/sjdfs.2017.194773
N. Hassan, M. Keshta, H. Ebeed, O. Hassanin
A field experiment was carried out to evaluate the responses of six oil sunflower ( Helianthus annuus L) genotypes namely; Sakha 53, H(A9XRf6), B11, B12, H(A9XRf8) and B20 to drought stress. Plants were subjected to three levels of water: adequate (control), moderate drought and severe drought Water regime was started directly post anthesis by withholding water during seed-filling stage until complete maturity of seeds. Moderate and severe drought decreased plant height and stem diameter of all genotypes, except B11 and B20 which recorded non-significant decrease in plant height under moderate drought. On the other hand, non-significant effect was observed in leaf area in all genotypes except B12 and H(A9XRf8) where a significant decrease was recorded only under severe drought. Yield components (head diameter, seed yield, 100 seed weight, seed husk %, seed kernel % , and oil percentage) responded to drought stress differently according to genotypes. Significant decreases were observed in floral head diameter seed yield, oil percentage and protein content in all genotypes except for the non-significant reduction in seed yield and oil content in Sakha53 and H(A9XRf6) under moderate drought Generally, Skha53 was the most drought-tolerant genotype whereas B11, B12 and B20 exhibited the least tolerance.
通过田间试验,评价了6个油葵(Helianthus annuus L)基因型(分别为;Sakha 53、H(A9XRf6)、B11、B12、H(A9XRf8)和B20对干旱胁迫的响应。植物受到三个水平的水分:充足(控制)、中度干旱和严重干旱。在种子灌浆阶段,水分直接在开花后开始,直到种子完全成熟。除B11和B20在中度干旱条件下株高下降不显著外,其余基因型株高和茎粗均下降。另一方面,除B12和H(A9XRf8)基因型的叶面积在严重干旱条件下显著减少外,其余基因型的叶面积均无显著影响。籽粒直径、籽粒产量、百粒重、籽皮%、籽粒%和含油率对干旱胁迫的响应因基因型而异。在中度干旱条件下,除Sakha53和H(A9XRf6)的种子产量和含油量降低不显著外,其余基因型的花头直径、种子产量、含油量和蛋白质含量均显著降低。总体而言,Skha53的耐旱性最强,B11、B12和B20的耐旱性最差。
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引用次数: 0
Evaluation of Water Quality of the Nile River at Damietta branch as affected by Omer Bek drain 奥默贝克排水对尼罗河达米埃塔支流水质影响的评价
Pub Date : 2017-12-01 DOI: 10.21608/sjdfs.2017.194764
M. Bahgat, W. Saber, M. Zaki
Over two-year period starting June 2014, 72 water samples were collected from Omar Bek drain, Damietta branch upstream and downstream. Based on physical, chemical and bacteriological results obtained, The physical analysis was temperature, pH, and turbidity, chemical analysis was total dissolved salts (TDS), electrical conductivity(EC), alkalinity, total hardness, manganese, iron, nitrite (NO2), nitrate (NO3), ammonia (NH3), dissolved oxygen (DO), and bacteriological analyses involved total coliforms (TC), fecal coliforms (FC), and Fecal Streptococci (FS). Results showed Omar Bek drain water carries high concentrations of pollutants which affected on all parameter of Nile River downstream. Also, the present investigation showed that Damietta branch upstream was a good raw water quality while Damietta branch downstream was affected by presence of Omer Bek drain.
从2014年6月开始,在两年多的时间里,从Omar Bek排水,Damietta分支上下游收集了72个水样。根据获得的物理、化学和细菌学结果,物理分析为温度、pH和浊度,化学分析为总溶解盐(TDS)、电导率(EC)、碱度、总硬度、锰、铁、亚硝酸盐(NO2)、硝酸盐(NO3)、氨(NH3)、溶解氧(DO),细菌学分析包括总大肠菌群(TC)、粪便大肠菌群(FC)和粪便链球菌(FS)。结果表明,Omar Bek排水中含有高浓度的污染物,对尼罗河下游的各项参数都有影响。调查还发现,上游Damietta支流原水水质较好,下游Damietta支流原水水质受到Omer Bek排水口的影响。
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引用次数: 0
期刊
Scientific Journal for Damietta Faculty of Science
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