Pub Date : 2022-05-31DOI: 10.15587/2519-4798.2022.257621
Yuliia Shapoval
The immune system plays an important role in the pathogenesis of endometrial hyperplasia (EH) and benign breast tumors, as in the body of women this system interacts closely with the reproductive system. Due to the fact that the transformation of endometrial cells and mammary glands is controlled by the immune system, it is important to study the redistribution of components of cellular and humoral immune components in women with combined pathology. The aim of the study was to study the state of cellular and humoral parts of the immune system in women of reproductive age, patients with endometrial hyperplasia and benign breast tumors. Materials and methods. Studies of the state of the immune cell were performed in peripheral blood to determine the subpopulation composition of blood lymphocytes using monoclonal antibodies to antigens CD3 + (total number of T lymphocytes), CD4 + (T-helpers), CD8 + (T-suppressors), CD16 + (NK cells), CD19 + (B-lymphocytes). Indicators of humoral immunity - immunoglobulins (Ig) of classes A, M and G were determined using monospecific sera against these immunoglobulins. Results of the research. There was a decrease in the mean values of T-lymphocytes, T-suppressors, T-helpers and B-lymphocytes with a simultaneous increase in NK cells in the peripheral blood in patients with GE and mastopathy compared with the control group. There was a decrease in the immunoregulatory index - the ratio of CD4 + / CD8 +. An increase in the content of Ig G and a decrease in the levels of Ig M and Ig A in the groups of patients with GE and in the combination of GE and mastopathy in comparison with healthy women is shown. Conclusions. Immunological homeostasis, which is characterized by changes in cellular and humoral immunity at the systemic level, is involved in the violation of reproductive function in women with hormonal imbalance, which leads to the development of GE and mastopathy
{"title":"State of cellular and humoral systemic immunity in women of reproductive age under the development of proliferative processes in the endometry of the uterus and breast glands","authors":"Yuliia Shapoval","doi":"10.15587/2519-4798.2022.257621","DOIUrl":"https://doi.org/10.15587/2519-4798.2022.257621","url":null,"abstract":"The immune system plays an important role in the pathogenesis of endometrial hyperplasia (EH) and benign breast tumors, as in the body of women this system interacts closely with the reproductive system. Due to the fact that the transformation of endometrial cells and mammary glands is controlled by the immune system, it is important to study the redistribution of components of cellular and humoral immune components in women with combined pathology. \u0000The aim of the study was to study the state of cellular and humoral parts of the immune system in women of reproductive age, patients with endometrial hyperplasia and benign breast tumors. \u0000Materials and methods. Studies of the state of the immune cell were performed in peripheral blood to determine the subpopulation composition of blood lymphocytes using monoclonal antibodies to antigens CD3 + (total number of T lymphocytes), CD4 + (T-helpers), CD8 + (T-suppressors), CD16 + (NK cells), CD19 + (B-lymphocytes). Indicators of humoral immunity - immunoglobulins (Ig) of classes A, M and G were determined using monospecific sera against these immunoglobulins. \u0000Results of the research. There was a decrease in the mean values of T-lymphocytes, T-suppressors, T-helpers and B-lymphocytes with a simultaneous increase in NK cells in the peripheral blood in patients with GE and mastopathy compared with the control group. There was a decrease in the immunoregulatory index - the ratio of CD4 + / CD8 +. An increase in the content of Ig G and a decrease in the levels of Ig M and Ig A in the groups of patients with GE and in the combination of GE and mastopathy in comparison with healthy women is shown. \u0000Conclusions. Immunological homeostasis, which is characterized by changes in cellular and humoral immunity at the systemic level, is involved in the violation of reproductive function in women with hormonal imbalance, which leads to the development of GE and mastopathy","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77857351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-31DOI: 10.15587/2519-4798.2022.258354
S. Shcherbakov, H. Mazurenko, I. Yovenko
The aim of this study was to evaluate the clinical efficacy and safety of a two-dose approach in the administration of tocilizumab in patients with SARS COVID19 Material and methods. The study was carried out on the basis of the Odrex Medical House in 2000-2021. The total sample included 4,112 patients hospitalized in a specialized department with coronavirus pneumonia. Of this sample, 150 patients were prescribed tocilizumab at a dose of 8 mg/kg of patient weight, including 36 (24.0 %) cases when tocilizumab was administered in a two-dose regimen. In the case of a two-dose regimen, the second dose was administered no earlier than 24 hours after the first one. All patients were examined according to the current clinical protocols. The hemogram, the content of CRP, ferritin, interleukin-6 were assessed. All patients received dexamethasone intramuscularly at a dose of at least 6 mg per day. Statistical processing was carried out by methods of analysis of variance using the software Statistica 13.0. Results. After the use of tocilizumab, the patients had a decrease in body temperature and a decrease in the need for oxygen support. At the same time, the normalization of indicators of the activity of the systemic inflammatory response was observed. Mortality after the use of tocilizumab was 29.3 %; in all cases, the deaths had an extremely severe course of coronavirus infection and a significant comorbid background. There were no manifestations of anaphylaxis and cases of secondary infection after the appointment of tocilizumab. Conclusions. The use of tocilizumab could significantly improve the condition of patients with SARS COVID19. There were no signs of anaphylaxis and cases of secondary infection after the administration of tocilizumab. In the absence of a pronounced clinical effect within 24 hours after the first dose of tocilizumab in patients with severe SARS COVID19, it is advisable to re-administer the drug (two-dose regimen)
{"title":"IL6-inhibitors in treatment of SARS COVID19","authors":"S. Shcherbakov, H. Mazurenko, I. Yovenko","doi":"10.15587/2519-4798.2022.258354","DOIUrl":"https://doi.org/10.15587/2519-4798.2022.258354","url":null,"abstract":"The aim of this study was to evaluate the clinical efficacy and safety of a two-dose approach in the administration of tocilizumab in patients with SARS COVID19 \u0000Material and methods. The study was carried out on the basis of the Odrex Medical House in 2000-2021. The total sample included 4,112 patients hospitalized in a specialized department with coronavirus pneumonia. Of this sample, 150 patients were prescribed tocilizumab at a dose of 8 mg/kg of patient weight, including 36 (24.0 %) cases when tocilizumab was administered in a two-dose regimen. In the case of a two-dose regimen, the second dose was administered no earlier than 24 hours after the first one. \u0000All patients were examined according to the current clinical protocols. The hemogram, the content of CRP, ferritin, interleukin-6 were assessed. All patients received dexamethasone intramuscularly at a dose of at least 6 mg per day. \u0000Statistical processing was carried out by methods of analysis of variance using the software Statistica 13.0. \u0000Results. After the use of tocilizumab, the patients had a decrease in body temperature and a decrease in the need for oxygen support. At the same time, the normalization of indicators of the activity of the systemic inflammatory response was observed. \u0000Mortality after the use of tocilizumab was 29.3 %; in all cases, the deaths had an extremely severe course of coronavirus infection and a significant comorbid background. There were no manifestations of anaphylaxis and cases of secondary infection after the appointment of tocilizumab. \u0000Conclusions. The use of tocilizumab could significantly improve the condition of patients with SARS COVID19. There were no signs of anaphylaxis and cases of secondary infection after the administration of tocilizumab. In the absence of a pronounced clinical effect within 24 hours after the first dose of tocilizumab in patients with severe SARS COVID19, it is advisable to re-administer the drug (two-dose regimen)","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82120707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-31DOI: 10.15587/2519-4798.2022.258496
M. Neelima, Anitha Sunkara, Saritha Karre, Maluthu Devojee, Dharavath Kavitha
Interface dermatitis is a broad term used for all the lesions having clinical features and histological features of epidermal basal cell damage and extensive mononuclear cell infiltration in the papillary dermis, all these lesions are also known as lichenoid dermatosis or “Lichenoid tissue reaction” (LTR). The aim of the study was to study in detail histopathological findings associated with interface dermatitis. Materials and methods: a total of 112 cases were studied. Material for this study included patients who were clinically diagnosed as having interface Dermatitis from the Department of Dermatology, Gandhi Medical College, Secunderabad, during the period from 2009-2011. Results: clinical diagnosis of the 112 cases diagnosed as interface dermatitis in the present study were as follows: The maximum number of cases 44 (39.29 %) were those of Lichen Planus, followed by discoid lupus erythematosus 10 (8.93 %), vitiligo 10 (8.93 %), lichen planus pigmentosus 9 (8.04 %), erythema multiforme 9 (8.04 %), subacute lupus erythematosus 6 (5.36 %), fixed drug eruption 6 (5.36 %), lichen sclerosis et atrophicus 6 (5.36 %), hypertropic lichen planus 6 (5.36 %) and 1 case of linear lichen planus, lichen plano pilaris, lichen nitidus, bullous lichen planus, atrophic lichen planus, lichen amyloidosis, and drug induced lichenoid reaction. Conclusion: the interface dermatitis encompasses disease in which there is epidermal basal cell damage, apoptosis of the cell with formation of colloid & civatte bodies, hydropic degeneration of the basal cell, basement membrane thickening, band like or patchy inflammatory infiltrate hugging the dermoepidermal junction and melanin incontinence
{"title":"Study of clinical and histopathological findings of interface dermatitis and its correlation","authors":"M. Neelima, Anitha Sunkara, Saritha Karre, Maluthu Devojee, Dharavath Kavitha","doi":"10.15587/2519-4798.2022.258496","DOIUrl":"https://doi.org/10.15587/2519-4798.2022.258496","url":null,"abstract":"Interface dermatitis is a broad term used for all the lesions having clinical features and histological features of epidermal basal cell damage and extensive mononuclear cell infiltration in the papillary dermis, all these lesions are also known as lichenoid dermatosis or “Lichenoid tissue reaction” (LTR). \u0000The aim of the study was to study in detail histopathological findings associated with interface dermatitis. \u0000Materials and methods: a total of 112 cases were studied. Material for this study included patients who were clinically diagnosed as having interface Dermatitis from the Department of Dermatology, Gandhi Medical College, Secunderabad, during the period from 2009-2011. \u0000Results: clinical diagnosis of the 112 cases diagnosed as interface dermatitis in the present study were as follows: The maximum number of cases 44 (39.29 %) were those of Lichen Planus, followed by discoid lupus erythematosus 10 (8.93 %), vitiligo 10 (8.93 %), lichen planus pigmentosus 9 (8.04 %), erythema multiforme 9 (8.04 %), subacute lupus erythematosus 6 (5.36 %), fixed drug eruption 6 (5.36 %), lichen sclerosis et atrophicus 6 (5.36 %), hypertropic lichen planus 6 (5.36 %) and 1 case of linear lichen planus, lichen plano pilaris, lichen nitidus, bullous lichen planus, atrophic lichen planus, lichen amyloidosis, and drug induced lichenoid reaction. \u0000Conclusion: the interface dermatitis encompasses disease in which there is epidermal basal cell damage, apoptosis of the cell with formation of colloid & civatte bodies, hydropic degeneration of the basal cell, basement membrane thickening, band like or patchy inflammatory infiltrate hugging the dermoepidermal junction and melanin incontinence","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90083977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-31DOI: 10.15587/2519-4798.2022.256908
M. Stovban, A. Tolstanov, O. Kravchenko
This article presents a retrospective analysis relating to the main performance indicators of the Kosovo Central District Hospital (CDH). The author's method of calculating the efficiency of the hospital on the components of medical, social and economic efficiency is proposed. The reason for the low level of efficiency of the Kosovo CDH is substantiated and ways to increase the efficiency are suggested. The aim of this article is to conduct a retrospective analysis of the effectiveness of the Kosiv Central District Hospital to identify the main problems of local hospitals and to formulate scientifically sound proposals for improving the medical system in the newly formed united territorial communities. Research methods. In the article were used general scientific research methods: Analysis and synthesis, in the study of scientific literature and determining the effectiveness of the Kosiv CDH; Economic and statistical analysis and comparison, when calculating indicators of medical, social and economic efficiency of the Kosiv CDH, Generalization - when developing recommendations for improving the efficiency of the Kosiv CDH. Results: The author's method of calculating indicators for assessing the medical, social, and economic efficiency of the Kosiv CDH was developed. A retrospective analysis of the effectiveness of the Kosiv CDH was conducted, which allowed us to state the low level of efficiency, which was formed under the influence of factors independent of the hospital itself. The necessity of introduction of paid medical services and their realization by the Kosiv CDH, development of public-private partnership and the mechanism of acquisition of the diagnostic car for realization of programs on complex diagnostics of health of the population of the Kosiv city united territorial community are substantiated. Conclusions. A retrospective analysis of the effectiveness of the Kosiv CDH in 2014-2018 allowed us to conclude that the level of such efficiency is quite low. However, the low level of efficiency of the Kosiv CDH is due to the existing principles of medical development in Ukraine, which is, “de jure” based on the concept of free medical care
{"title":"Retrospective analysis of the main indicators of Kosiv CRH efficiency for the period 2014–2018","authors":"M. Stovban, A. Tolstanov, O. Kravchenko","doi":"10.15587/2519-4798.2022.256908","DOIUrl":"https://doi.org/10.15587/2519-4798.2022.256908","url":null,"abstract":"This article presents a retrospective analysis relating to the main performance indicators of the Kosovo Central District Hospital (CDH). \u0000The author's method of calculating the efficiency of the hospital on the components of medical, social and economic efficiency is proposed. The reason for the low level of efficiency of the Kosovo CDH is substantiated and ways to increase the efficiency are suggested. \u0000The aim of this article is to conduct a retrospective analysis of the effectiveness of the Kosiv Central District Hospital to identify the main problems of local hospitals and to formulate scientifically sound proposals for improving the medical system in the newly formed united territorial communities. \u0000Research methods. In the article were used general scientific research methods: \u0000Analysis and synthesis, in the study of scientific literature and determining the effectiveness of the Kosiv CDH; \u0000Economic and statistical analysis and comparison, when calculating indicators of medical, social and economic efficiency of the Kosiv CDH, \u0000Generalization - when developing recommendations for improving the efficiency of the Kosiv CDH. \u0000Results: The author's method of calculating indicators for assessing the medical, social, and economic efficiency of the Kosiv CDH was developed. \u0000A retrospective analysis of the effectiveness of the Kosiv CDH was conducted, which allowed us to state the low level of efficiency, which was formed under the influence of factors independent of the hospital itself. \u0000The necessity of introduction of paid medical services and their realization by the Kosiv CDH, development of public-private partnership and the mechanism of acquisition of the diagnostic car for realization of programs on complex diagnostics of health of the population of the Kosiv city united territorial community are substantiated. \u0000Conclusions. A retrospective analysis of the effectiveness of the Kosiv CDH in 2014-2018 allowed us to conclude that the level of such efficiency is quite low. However, the low level of efficiency of the Kosiv CDH is due to the existing principles of medical development in Ukraine, which is, “de jure” based on the concept of free medical care","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75852343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-31DOI: 10.15587/2519-4798.2022.257496
Sardar Jaideep Singh, K. Sree, Shanmukha Srinivas, Sujatha Pasula
The femur is the largest bone in the body connecting between the tibia and pelvic bone. Studies have proved this bimodal distribution of supracondylar fractures of the femur. The locking plate's standard is to have an anatomical reduction of the bone under the soft tissue envelope and could be applied without stripping the periosteum. The aim: to study the union rates with locking compression plates and clinical outcome associated with this treatment modality, range of movements of the knee, pain relief and return to normal activities and work. Methodology: this is a prospective study on patients with distal femur fractures. Conducted at Santhiram medical college and general hospital, Nandyal from October 2018 to September 2020. All patients aged more than 18 years diagnosed with distal femur fractures. Results: in our study, around 46 % of them had Muller A1 type, followed by 23 % had Muller C1 and C2 respectively, and the remaining 13.3 % had Muller A2. Around 67 % had a Thomas splint with traction, 16.7 % had B.B. splint, 13.3 % had A/K POP slab, and the remaining 3 % had upper tibial traction with B.B. splint. The majority of the study participants, 53 %, had knee flexion more than 120 degrees. 30 %, took <16 weeks for the union, 33 %, took 16-20 weeks to complete weight-bearing, eight patients (26 %) had excellent outcomes; 21 patients (70 %) had a satisfactory outcome; one patient (3.3 %) had an unsatisfactory outcome. Conclusion: in our study, out of 30 patients, eight patients had excellent outcomes, 21 patients had satisfactory outcomes, and one patient had unsatisfactory outcomes. We conclude, open reduction and internal fixation with a locking compression plate resulted in good clinical and radiologic outcomes
{"title":"A study of functional outcome of distal femur fractures internally fixed with distal femur locking compression plate","authors":"Sardar Jaideep Singh, K. Sree, Shanmukha Srinivas, Sujatha Pasula","doi":"10.15587/2519-4798.2022.257496","DOIUrl":"https://doi.org/10.15587/2519-4798.2022.257496","url":null,"abstract":"The femur is the largest bone in the body connecting between the tibia and pelvic bone. Studies have proved this bimodal distribution of supracondylar fractures of the femur. The locking plate's standard is to have an anatomical reduction of the bone under the soft tissue envelope and could be applied without stripping the periosteum. \u0000The aim: to study the union rates with locking compression plates and clinical outcome associated with this treatment modality, range of movements of the knee, pain relief and return to normal activities and work. \u0000Methodology: this is a prospective study on patients with distal femur fractures. Conducted at Santhiram medical college and general hospital, Nandyal from October 2018 to September 2020. All patients aged more than 18 years diagnosed with distal femur fractures. \u0000Results: in our study, around 46 % of them had Muller A1 type, followed by 23 % had Muller C1 and C2 respectively, and the remaining 13.3 % had Muller A2. Around 67 % had a Thomas splint with traction, 16.7 % had B.B. splint, 13.3 % had A/K POP slab, and the remaining 3 % had upper tibial traction with B.B. splint. The majority of the study participants, 53 %, had knee flexion more than 120 degrees. 30 %, took <16 weeks for the union, 33 %, took 16-20 weeks to complete weight-bearing, eight patients (26 %) had excellent outcomes; 21 patients (70 %) had a satisfactory outcome; one patient (3.3 %) had an unsatisfactory outcome. \u0000Conclusion: in our study, out of 30 patients, eight patients had excellent outcomes, 21 patients had satisfactory outcomes, and one patient had unsatisfactory outcomes. We conclude, open reduction and internal fixation with a locking compression plate resulted in good clinical and radiologic outcomes","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83258386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-31DOI: 10.15587/2519-4798.2022.257003
M. Koteliukh
The aim of the work was to study the characteristics of adipokine metabolism based on the analysis of fatty acid binding protein 4 (FABP4) and C1q/tumour necrosis factor-related protein-3 (CTRP3) levels and their dynamics in non-diabetic and diabetic patients with cardiovascular (CV) complications of acute myocardial infarction (AMI). Materials and methods. The study was carried out between 2018 and 2020 and involved 134 AMI patients with or without type 2 diabetes mellitus (DM) aged 59.00 [52.75; 66.00] years. The control group consisted of 20 healthy individuals with the mean age of 56.50 [48.50; 61.75] years. The serum levels of FABP4 and CTRP3 were measured by enzyme-linked immunosorbent assay on days 1 and 10 of hospital stay. Results. The mean levels of FABP4 were elevated on day 1 in AMI patients with type 2 DM (group II) compared to those in AMI patients (group I) and the control individuals (p<0.05). The FABP4 concentrations on day 10 were 7.68 [6.42; 8.42] ng/ml and 8.31 [6.92; 9.63] ng/ml (p<0.05) in groups I and II, respectively. The CTRP3 levels were lower in group II on day 1 as compared to those in group I and the control group patients (p<0.001). After 10 days, the levels of CTRP3 were 287.56 [271.48; 300.58] ng/ml and 262.01 [225.32; 288.84] ng/ml) (p<0.001) in groups I and II, respectively. In the presence of early AMI complications in diabetic patients, the levels of FABP4 remained elevated on day 10, and the levels of CTRP3 were low compared to those in diabetic patients without AMI complications (p<0.05). Conclusions. The characteristics of adipokine metabolism in AMI patients have been revealed: the worsened imbalance in adipokine metabolism in type 2 DM due to the difference in FABP4 and CTRP3 levels. Special mention should be made of severely deteriorated adipokine metabolism in diabetic patients with CV complications
{"title":"Dynamics of FABP4 and CTRP3 biomarkers in patients with acute myocardial infarction and type 2 diabetes mellitus","authors":"M. Koteliukh","doi":"10.15587/2519-4798.2022.257003","DOIUrl":"https://doi.org/10.15587/2519-4798.2022.257003","url":null,"abstract":"The aim of the work was to study the characteristics of adipokine metabolism based on the analysis of fatty acid binding protein 4 (FABP4) and C1q/tumour necrosis factor-related protein-3 (CTRP3) levels and their dynamics in non-diabetic and diabetic patients with cardiovascular (CV) complications of acute myocardial infarction (AMI). \u0000Materials and methods. The study was carried out between 2018 and 2020 and involved 134 AMI patients with or without type 2 diabetes mellitus (DM) aged 59.00 [52.75; 66.00] years. The control group consisted of 20 healthy individuals with the mean age of 56.50 [48.50; 61.75] years. The serum levels of FABP4 and CTRP3 were measured by enzyme-linked immunosorbent assay on days 1 and 10 of hospital stay. \u0000Results. The mean levels of FABP4 were elevated on day 1 in AMI patients with type 2 DM (group II) compared to those in AMI patients (group I) and the control individuals (p<0.05). The FABP4 concentrations on day 10 were 7.68 [6.42; 8.42] ng/ml and 8.31 [6.92; 9.63] ng/ml (p<0.05) in groups I and II, respectively. The CTRP3 levels were lower in group II on day 1 as compared to those in group I and the control group patients (p<0.001). After 10 days, the levels of CTRP3 were 287.56 [271.48; 300.58] ng/ml and 262.01 [225.32; 288.84] ng/ml) (p<0.001) in groups I and II, respectively. In the presence of early AMI complications in diabetic patients, the levels of FABP4 remained elevated on day 10, and the levels of CTRP3 were low compared to those in diabetic patients without AMI complications (p<0.05). \u0000Conclusions. The characteristics of adipokine metabolism in AMI patients have been revealed: the worsened imbalance in adipokine metabolism in type 2 DM due to the difference in FABP4 and CTRP3 levels. Special mention should be made of severely deteriorated adipokine metabolism in diabetic patients with CV complications","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88235491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-31DOI: 10.15587/2519-4798.2022.257524
H. Rani, J. Rao, G. Vaishnavi
Spinal anesthesia is preferred choice of anesthesia in lower abdominal surgeries for a long time. However, the problem with this is limited duration of action, so for long duration surgeries alternatives are required. The aim: to compare the intra-operative effects of a low dose of intrathecal tramadol and intrathecal fentanyl with hyperbaric bupivacaine hydrochloride. Materials and methods: prospective randomized control study for a duration of study is one year. 50 patients, aged 18 years to 60 years, belonging to ASA physical status I and II, posted for elective lower abdominal surgeries under spinal anaesthesia were chosen. These patients were divided into two groups: group BT- this group of patients received 2.5 mL volume of 0.5 % hyperbaric bupivacaine with 25 mg of tramadol intrathecally. Group BF- this group of patients received 2.5 mL volume of 0.5 % hyperbaric bupivacaine with 25 μg of fentanyl intrathecally. Results: demographic parameters in both the groups are not statistically significant. The association between the differences in duration of surgeries of both the study groups is not statistically. The association between the differences in mean time of onset of sensory block and motor block of both the study groups was comparable with p>0.05 The duration of sensory block (analgesia) and duration of motor block difference between the two means was statistically significant with p<0.0000001. The difference between the mean VAS score at 3 hours and at 20 hours was statistically significant with p<0.05. Among the study BT group, 52 % needed 2 analgesics and 48 % needed 3 doses of analgesics. Among BF group, 6 % needed only one dose of analgesics and 44 % needed 2 doses of analgesics. The difference between the two was statistically significant with p<0.000002. The association between the hemodynamic variables between both the groups at the end of procedure was statistically significant with p<0.05. Conclusions: Intrathecal fentanyl and tramadol produced a similar onset of sensory and motor blocks. Fentanyl provided better duration and quality of postoperative analgesia compared to tramadol
{"title":"Comparative study of intrathecal tramadol and fentanyl as adjuvants in lower abdominal surgeries","authors":"H. Rani, J. Rao, G. Vaishnavi","doi":"10.15587/2519-4798.2022.257524","DOIUrl":"https://doi.org/10.15587/2519-4798.2022.257524","url":null,"abstract":"Spinal anesthesia is preferred choice of anesthesia in lower abdominal surgeries for a long time. However, the problem with this is limited duration of action, so for long duration surgeries alternatives are required. \u0000The aim: to compare the intra-operative effects of a low dose of intrathecal tramadol and intrathecal fentanyl with hyperbaric bupivacaine hydrochloride. \u0000Materials and methods: prospective randomized control study for a duration of study is one year. 50 patients, aged 18 years to 60 years, belonging to ASA physical status I and II, posted for elective lower abdominal surgeries under spinal anaesthesia were chosen. \u0000These patients were divided into two groups: group BT- this group of patients received 2.5 mL volume of 0.5 % hyperbaric bupivacaine with 25 mg of tramadol intrathecally. Group BF- this group of patients received 2.5 mL volume of 0.5 % hyperbaric bupivacaine with 25 μg of fentanyl intrathecally. \u0000Results: demographic parameters in both the groups are not statistically significant. The association between the differences in duration of surgeries of both the study groups is not statistically. The association between the differences in mean time of onset of sensory block and motor block of both the study groups was comparable with p>0.05 \u0000The duration of sensory block (analgesia) and duration of motor block difference between the two means was statistically significant with p<0.0000001. The difference between the mean VAS score at 3 hours and at 20 hours was statistically significant with p<0.05. Among the study BT group, 52 % needed 2 analgesics and 48 % needed 3 doses of analgesics. Among BF group, 6 % needed only one dose of analgesics and 44 % needed 2 doses of analgesics. The difference between the two was statistically significant with p<0.000002. The association between the hemodynamic variables between both the groups at the end of procedure was statistically significant with p<0.05. \u0000Conclusions: Intrathecal fentanyl and tramadol produced a similar onset of sensory and motor blocks. Fentanyl provided better duration and quality of postoperative analgesia compared to tramadol","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83361970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-31DOI: 10.15587/2519-4798.2022.258497
I. Rudyk, D. Babichev, O. Medentseva, I. Gasanov
The aim: to evaluate the probable impact of type 2 diabetes on quality of life, clinical, biochemical and ultrasonographic parameters in patients with HFwmrLVEF and associations between them. Materials and methods: the study included 68 patients with HFwmrLVEF, including 36 patients with concomitant DM type 2 and 32 patients without type 2 DM, and 18 healthy individuals. All study participants underwent anthropometric (height, weight, BMI), laboratory (clinical blood test, biochemical blood test to determine ACT, ALT, creatinine, glucose, lipid spectrum, potassium, sodium and magnesium, ELISA to determine glycated hemoglobin and NT-proBN ), instrumental (EchoC, ECG) surveys and surveys to assess quality of life (EQ-5D-5L). Statistical processing of the obtained results was performed using the statistical software package SPSS v.19.0. Results: between the group of patients with HFwmrLVEF with concomitant type 2 DM and the group with HFwmrLVEF without type 2 DM according to the results of the study there is a significant difference in quality of life in carbohydrate metabolism, NT-proBNP, BMI and echocardiographic data. Conclusions: patients with HFwmrLVEF with concomitant type 2 DM compared with patients with HFwmrLVEF without type 2 DM had significantly worse carbohydrate metabolism, significantly higher mean serum NT-proBNP concentration, higher LVMM and iLVMM in transthoracic E quality of life according to the results of the EQ-5D-5L questionnaire in the absence of a significant difference in age and LVEF between groups. In addition, there was a stronger correlation between NT-proBNP and iLVMM in patients without type 2 DM and no correlation between NT-proBNP and LVMM in patients with concomitant type 2 DM, which may be due to certain influence of type 2 DM on the process of pro-BNP conversion
{"title":"Association between ultrasonographic parameters, clinical and biochemical indicators and results of surveys in patients with heart failure with moderately reduced left ventricle fraction","authors":"I. Rudyk, D. Babichev, O. Medentseva, I. Gasanov","doi":"10.15587/2519-4798.2022.258497","DOIUrl":"https://doi.org/10.15587/2519-4798.2022.258497","url":null,"abstract":"The aim: to evaluate the probable impact of type 2 diabetes on quality of life, clinical, biochemical and ultrasonographic parameters in patients with HFwmrLVEF and associations between them.\u0000Materials and methods: the study included 68 patients with HFwmrLVEF, including 36 patients with concomitant DM type 2 and 32 patients without type 2 DM, and 18 healthy individuals. All study participants underwent anthropometric (height, weight, BMI), laboratory (clinical blood test, biochemical blood test to determine ACT, ALT, creatinine, glucose, lipid spectrum, potassium, sodium and magnesium, ELISA to determine glycated hemoglobin and NT-proBN ), instrumental (EchoC, ECG) surveys and surveys to assess quality of life (EQ-5D-5L). Statistical processing of the obtained results was performed using the statistical software package SPSS v.19.0.\u0000Results: between the group of patients with HFwmrLVEF with concomitant type 2 DM and the group with HFwmrLVEF without type 2 DM according to the results of the study there is a significant difference in quality of life in carbohydrate metabolism, NT-proBNP, BMI and echocardiographic data.\u0000Conclusions: patients with HFwmrLVEF with concomitant type 2 DM compared with patients with HFwmrLVEF without type 2 DM had significantly worse carbohydrate metabolism, significantly higher mean serum NT-proBNP concentration, higher LVMM and iLVMM in transthoracic E quality of life according to the results of the EQ-5D-5L questionnaire in the absence of a significant difference in age and LVEF between groups. In addition, there was a stronger correlation between NT-proBNP and iLVMM in patients without type 2 DM and no correlation between NT-proBNP and LVMM in patients with concomitant type 2 DM, which may be due to certain influence of type 2 DM on the process of pro-BNP conversion","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78658931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-31DOI: 10.15587/2519-4798.2022.258096
Zhanna Sotnikova-Meleshkina, T. Havrylova, O. Zinchuk, I. Dudnyk
The aim: to describe the dynamic changes in mental capacity during education in secondary school in the implementation of traditional and meritocratic educational program. Materials and methods. The study involved 56 secondary schoolchildren in the dynamics of learning, which were divided into 2 groups depending on the education system. The level of mental capacity was assessed using proofreading tests of V. Ya. Anfimov. Statistical data processing was performed using one-way analysis of variance and t-test in the software package IBM SPSS Statistics 20. Results. During the period of basic education, the level of influence of the type of educational program, type of subject and day of the week on the accuracy of the test performance increased, the amount of work increased by 16.2-16.7 % (p<0.01) and its accuracy decreased (p<0,05). Higher initial and post-load intensity of mental capacity was revealed in schoolchildren with meritocratic education (353.23±8.52 and 341.41±8.65 respectively), and with a traditional system - higher and stable accuracy (5.68-5.86 errors) and productivity of mental work (35.29-35.72 conventional units; p<0.01). The weekly efficiency curve was the opposite in terms of accuracy for 6th and 9th grade schoolchildren, and the identical in terms of volume. In meritocratic education, a higher level of intensity was registered in the mathematics lesson, and in the traditional educational program − accuracy against the background of negative dynamics of quantitative and complex indicators. Conclusions. Gender and age features of intensity, accuracy and productivity of mental work during basic education and the level of influence of factors of the educational process on them are established. The increase in the level of educational load was accompanied by an increase in the intensity and accuracy of mental work due to the adaptation of schoolchildren to the peculiarities of learning in secondary school and the stabilization of physiological processes. Comparison of weekly curves of mental capacity during training allowed to identify certain age trends in the formation of mental fatigue
{"title":"Dynamics of mental capacity of schoolchildren during study in secondary school under conditions of implementation of various educational programs","authors":"Zhanna Sotnikova-Meleshkina, T. Havrylova, O. Zinchuk, I. Dudnyk","doi":"10.15587/2519-4798.2022.258096","DOIUrl":"https://doi.org/10.15587/2519-4798.2022.258096","url":null,"abstract":"The aim: to describe the dynamic changes in mental capacity during education in secondary school in the implementation of traditional and meritocratic educational program. \u0000Materials and methods. The study involved 56 secondary schoolchildren in the dynamics of learning, which were divided into 2 groups depending on the education system. The level of mental capacity was assessed using proofreading tests of V. Ya. Anfimov. Statistical data processing was performed using one-way analysis of variance and t-test in the software package IBM SPSS Statistics 20. \u0000Results. During the period of basic education, the level of influence of the type of educational program, type of subject and day of the week on the accuracy of the test performance increased, the amount of work increased by 16.2-16.7 % (p<0.01) and its accuracy decreased (p<0,05). Higher initial and post-load intensity of mental capacity was revealed in schoolchildren with meritocratic education (353.23±8.52 and 341.41±8.65 respectively), and with a traditional system - higher and stable accuracy (5.68-5.86 errors) and productivity of mental work (35.29-35.72 conventional units; p<0.01). The weekly efficiency curve was the opposite in terms of accuracy for 6th and 9th grade schoolchildren, and the identical in terms of volume. In meritocratic education, a higher level of intensity was registered in the mathematics lesson, and in the traditional educational program − accuracy against the background of negative dynamics of quantitative and complex indicators. \u0000Conclusions. Gender and age features of intensity, accuracy and productivity of mental work during basic education and the level of influence of factors of the educational process on them are established. The increase in the level of educational load was accompanied by an increase in the intensity and accuracy of mental work due to the adaptation of schoolchildren to the peculiarities of learning in secondary school and the stabilization of physiological processes. Comparison of weekly curves of mental capacity during training allowed to identify certain age trends in the formation of mental fatigue","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75540959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-31DOI: 10.15587/2519-4798.2022.254042
D. Mandsorwale, B. Sharma
The aim. To access the superiority of myeloperoxidase & oxidized low-density lipoproteins over each other acts as a better predictive marker gaining information regarding the severity of cardiovascular disease. Materials and methods. 215 subjects are taken into consideration of which 54 are healthy controls, 52 are from stable angina pectoris, 53 are taken from unstable angina pectoris and 56 subjects are from acute myocardial infarction. Lipid profile parameters, oxidative stress markers, plasma myeloperoxidase and plasma oxidized low density lipoproteins were estimated by kit methods, thiobarbituric acid reactive substances method, and colorimetric assay, sandwich and competitive enzyme linked immunosorbent assay techniques, respectively. Results were present as mean ± SD, p-values <0.05 as significant, and Student’s unpaired “t” test. Comparative analysis by box and whiskers plot to check skewness and deviations within the values. Data analysis was performed by software package SPSS version 17.0. Results. The oxidized low density lipoproteins levels found significantly elevated in all three cases subgroup contrary to insignificant levels of myeloperoxidase in stable angina pectoris compared to control. Box and whisker plot of myeloperoxidase levels showed no skewness in stable angina pectoris (non-significant), whereas unstable angina pectoris and acute myocardial infarction showed right skewness (highly significant), whereas plots of oxidized low-density lipoproteins show extensive interquartile range in the stable angina pectoris subgroup, suggesting scattered deviation in the mean values compared to unstable angina pectoris and acute myocardial infarction subgroup. Conclusions. The study concluded that significantly elevated level of oxidized low-density lipoproteins in stable angina pectoris, unstable angina pectoris, and acute myocardial infarction subgroups with a scattered deviation of oxidized low density lipoproteins levels in the stable angina pectoris subgroup reflects its low prognostic reliability compared to plasma myeloperoxidase with marginal deviation and in insignificant elevation in stable angina pectoris. Thus, plasma myeloperoxidase and oxidized low density lipoproteins levels serve as independent predictors of cardiovascular disease, but plasma myeloperoxidase levels predict an increased risk over oxidized low density lipoproteins for subsequent cardiovascular events in stable and unstable angina and extend the prognostic information gained from traditional biochemical markers
{"title":"Experimental and validation of significance and accuracy of oxidized low-density lipoproteins and myeloperoxidase in the screening of cardio-vascular disease","authors":"D. Mandsorwale, B. Sharma","doi":"10.15587/2519-4798.2022.254042","DOIUrl":"https://doi.org/10.15587/2519-4798.2022.254042","url":null,"abstract":"The aim. To access the superiority of myeloperoxidase & oxidized low-density lipoproteins over each other acts as a better predictive marker gaining information regarding the severity of cardiovascular disease. \u0000Materials and methods. 215 subjects are taken into consideration of which 54 are healthy controls, 52 are from stable angina pectoris, 53 are taken from unstable angina pectoris and 56 subjects are from acute myocardial infarction. Lipid profile parameters, oxidative stress markers, plasma myeloperoxidase and plasma oxidized low density lipoproteins were estimated by kit methods, thiobarbituric acid reactive substances method, and colorimetric assay, sandwich and competitive enzyme linked immunosorbent assay techniques, respectively. Results were present as mean ± SD, p-values <0.05 as significant, and Student’s unpaired “t” test. Comparative analysis by box and whiskers plot to check skewness and deviations within the values. Data analysis was performed by software package SPSS version 17.0. \u0000Results. The oxidized low density lipoproteins levels found significantly elevated in all three cases subgroup contrary to insignificant levels of myeloperoxidase in stable angina pectoris compared to control. Box and whisker plot of myeloperoxidase levels showed no skewness in stable angina pectoris (non-significant), whereas unstable angina pectoris and acute myocardial infarction showed right skewness (highly significant), whereas plots of oxidized low-density lipoproteins show extensive interquartile range in the stable angina pectoris subgroup, suggesting scattered deviation in the mean values compared to unstable angina pectoris and acute myocardial infarction subgroup. \u0000Conclusions. The study concluded that significantly elevated level of oxidized low-density lipoproteins in stable angina pectoris, unstable angina pectoris, and acute myocardial infarction subgroups with a scattered deviation of oxidized low density lipoproteins levels in the stable angina pectoris subgroup reflects its low prognostic reliability compared to plasma myeloperoxidase with marginal deviation and in insignificant elevation in stable angina pectoris. Thus, plasma myeloperoxidase and oxidized low density lipoproteins levels serve as independent predictors of cardiovascular disease, but plasma myeloperoxidase levels predict an increased risk over oxidized low density lipoproteins for subsequent cardiovascular events in stable and unstable angina and extend the prognostic information gained from traditional biochemical markers","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85515653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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