Pub Date : 2022-01-30DOI: 10.15587/2519-4798.2022.252798
M. Lytvynenko
The fallopian tubes are a key link in the relationship between the uterus and the ovary. The aim of our study was to determine the effect of alcohol abuse and / or HIV infection on the morpho-functional state of the fallopian tubes in women of reproductive age. Material and methods. The study included sectional material, which was selected from 100 women of reproductive age (20 to 40 years), who were divided into four groups. The first group included section material from 25 women who had been laboratory confirmed for HIV. The second group included sectional material selected from 25 women suffering from chronic alcoholism. The third group consisted of sectional material from HIV-positive women who also showed signs of alcohol abuse. The fourth group includes sectional material selected from HIV-negative women. Results. Gross pathological changes in the structure of the fallopian tube, due to both the impact of HIV infection and alcohol abuse was identified in each of the groups. Changes in morphometric parameters (length of the ampullary part, outer diameter of the tube at the junction of the isthmus in the ampullary part, the area of the lumen of the ampullary part) can cause severe complications of inflammation or lead to ectopic pregnancy. The study of the epithelial and muscular layer revealed destructive-sclerotic changes, which consist in reducing the height of the epithelium and increasing the proportion of connective tissue in the muscular layer of the tube. Conclusions. According to the study, HIV and alcohol abuse are diseases that affect all elements of the fallopian tube. Thus, HIV infection and chronic alcohol abuse can exacerbate each other's negative effects on the female reproductive system and cause morphometric changes that can form a substrate for the development of inflammatory processes and lead to ectopic pregnancy
{"title":"Influence of alcohol abuse and / or HIV infection on morpho-functional condition of the uterine tube in women of reproductive age","authors":"M. Lytvynenko","doi":"10.15587/2519-4798.2022.252798","DOIUrl":"https://doi.org/10.15587/2519-4798.2022.252798","url":null,"abstract":"The fallopian tubes are a key link in the relationship between the uterus and the ovary. The aim of our study was to determine the effect of alcohol abuse and / or HIV infection on the morpho-functional state of the fallopian tubes in women of reproductive age. \u0000Material and methods. The study included sectional material, which was selected from 100 women of reproductive age (20 to 40 years), who were divided into four groups. The first group included section material from 25 women who had been laboratory confirmed for HIV. The second group included sectional material selected from 25 women suffering from chronic alcoholism. The third group consisted of sectional material from HIV-positive women who also showed signs of alcohol abuse. The fourth group includes sectional material selected from HIV-negative women. \u0000Results. Gross pathological changes in the structure of the fallopian tube, due to both the impact of HIV infection and alcohol abuse was identified in each of the groups. Changes in morphometric parameters (length of the ampullary part, outer diameter of the tube at the junction of the isthmus in the ampullary part, the area of the lumen of the ampullary part) can cause severe complications of inflammation or lead to ectopic pregnancy. The study of the epithelial and muscular layer revealed destructive-sclerotic changes, which consist in reducing the height of the epithelium and increasing the proportion of connective tissue in the muscular layer of the tube. \u0000Conclusions. According to the study, HIV and alcohol abuse are diseases that affect all elements of the fallopian tube. Thus, HIV infection and chronic alcohol abuse can exacerbate each other's negative effects on the female reproductive system and cause morphometric changes that can form a substrate for the development of inflammatory processes and lead to ectopic pregnancy","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90238279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-30DOI: 10.15587/2519-4798.2022.252809
D. Korchagina, Iegor Korchagin
The aim is to analyze current scientific data on the prevalence of thyroid dysfunction in patients with COVID-19 and to evaluate the relationship between possible complications of COVID-19 and vaccination. Materials and methods. Open digital archive of journal articles on biomedical and biological sciences of the National Institutes of Health (USA), developed by the National Center for Biotechnological Information of the National Medical Library (USA) – PubMed, Google Academy and Academic Journals. Results. The development of thyroid diseases in SARS-CoV-2 may be associated with various mechanisms of its damage, including an excessive immune response, infection-induced immunodeficiency, or direct cell damage due to significant tissue tropism and high affinity of SARS-CoV-2 to thyroid tissue. Possible mechanisms of formation of post-vaccination dysfunction of the thyroid gland are proposed. Conclusions. Thyroid hormone deficiency is associated with an increased risk of adverse events and in-hospital mortality of COVID-19 and depended on the age of the patient. The severe course of Covid-19 is characterized by an increase in the prevalence of TT secondary to destructive or inflammatory thyroiditis. Thyroid-related thyrotoxicosis exacerbates the clinical course of comorbidities and long-term consequences, such as autoimmune hypothyroidism, which occurs in patients of all ages and with any severity of COVID-19. The prevalence of TD in patients with COVID-19 varies from 13 to 64 %. 2. The presence of thyroid dysfunction is positively correlated with the clinical severity of COVID-19. Patients with confirmed thyroid disease should receive COVID-19 vaccine to reduce the risk of morbidity and mortality from COVID-19 infection
{"title":"COVID-19 and thyroid disease: clinical course and prognosis","authors":"D. Korchagina, Iegor Korchagin","doi":"10.15587/2519-4798.2022.252809","DOIUrl":"https://doi.org/10.15587/2519-4798.2022.252809","url":null,"abstract":"The aim is to analyze current scientific data on the prevalence of thyroid dysfunction in patients with COVID-19 and to evaluate the relationship between possible complications of COVID-19 and vaccination. \u0000Materials and methods. Open digital archive of journal articles on biomedical and biological sciences of the National Institutes of Health (USA), developed by the National Center for Biotechnological Information of the National Medical Library (USA) – PubMed, Google Academy and Academic Journals. \u0000Results. The development of thyroid diseases in SARS-CoV-2 may be associated with various mechanisms of its damage, including an excessive immune response, infection-induced immunodeficiency, or direct cell damage due to significant tissue tropism and high affinity of SARS-CoV-2 to thyroid tissue. Possible mechanisms of formation of post-vaccination dysfunction of the thyroid gland are proposed. \u0000Conclusions. Thyroid hormone deficiency is associated with an increased risk of adverse events and in-hospital mortality of COVID-19 and depended on the age of the patient. The severe course of Covid-19 is characterized by an increase in the prevalence of TT secondary to destructive or inflammatory thyroiditis. Thyroid-related thyrotoxicosis exacerbates the clinical course of comorbidities and long-term consequences, such as autoimmune hypothyroidism, which occurs in patients of all ages and with any severity of COVID-19. \u0000The prevalence of TD in patients with COVID-19 varies from 13 to 64 %. 2. The presence of thyroid dysfunction is positively correlated with the clinical severity of COVID-19. Patients with confirmed thyroid disease should receive COVID-19 vaccine to reduce the risk of morbidity and mortality from COVID-19 infection","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90531838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-30DOI: 10.15587/2519-4798.2022.252260
O. Dubenko, A. Chernenko
The aim of the work is to study the occurrence of psycho-emotional and autonomic disturbance and the impact of headache on the daily activities of patients with episodic migraine, depending on the presence of concomitant cervicalgia. Materials and methods: 77 patients with episodic migraine (17 with aura, 60 without aura, 28 men and 84 women, 18-58 years, mean 42.5±15.5 years) were included. 42 of them had concomitant cervicalgia. All patients were divided into 2 groups: I – episodic migraine with concomitant cervicalgia, II – episodic migraine without neck pain. The Spilberg-Hanin's anxiety scale, the Beck depression scale, Wayne questionnaire, Neck Disability Index and the MIDAS were used. Results. The number of psycho-emotional disorders was higher in group patients with combined episodic migraine and cervicalgia (p<0.05). The indicators of autonomic disturbance were also higher in I group (p<0.05). The indicators depression correlated with autonomic status on subjective signs symptoms of (r=0.380) and objective signs (r=0.554). In I group the autonomic disturbance on subjective signs correlated with state anxiety (r=0.312), trait anxiety (r=0.348) and Beck scale (r=0.351). In group II autonomic objective signs correlated with the patient’s self-assessment on the same scale (r=0.919). The level of neck disability on NDI correlated with autonomic dysfunction on objective signs (r=0.338) in I group. The decrease of daily activity was more significantly reduce on MIDAS in I group compare with II group. Conclusion. The combination of episodic migraine and cervicalgia in patients significantly reduces the daily activity rate on the MIDAS. The concomitant cervicalgia in patients with episodic migraine to contribute increase rates of state and trait anxiety and mild depressive symptoms and autonomic disturbance
{"title":"The influence of concomitant cervicalgia on the psycho-emotional and autonomic state and daily activity in patients with episodic migraine","authors":"O. Dubenko, A. Chernenko","doi":"10.15587/2519-4798.2022.252260","DOIUrl":"https://doi.org/10.15587/2519-4798.2022.252260","url":null,"abstract":"The aim of the work is to study the occurrence of psycho-emotional and autonomic disturbance and the impact of headache on the daily activities of patients with episodic migraine, depending on the presence of concomitant cervicalgia.\u0000Materials and methods: 77 patients with episodic migraine (17 with aura, 60 without aura, 28 men and 84 women, 18-58 years, mean 42.5±15.5 years) were included. 42 of them had concomitant cervicalgia. All patients were divided into 2 groups: I – episodic migraine with concomitant cervicalgia, II – episodic migraine without neck pain. The Spilberg-Hanin's anxiety scale, the Beck depression scale, Wayne questionnaire, Neck Disability Index and the MIDAS were used.\u0000Results. The number of psycho-emotional disorders was higher in group patients with combined episodic migraine and cervicalgia (p<0.05). The indicators of autonomic disturbance were also higher in I group (p<0.05). The indicators depression correlated with autonomic status on subjective signs symptoms of (r=0.380) and objective signs (r=0.554). In I group the autonomic disturbance on subjective signs correlated with state anxiety (r=0.312), trait anxiety (r=0.348) and Beck scale (r=0.351). In group II autonomic objective signs correlated with the patient’s self-assessment on the same scale (r=0.919). The level of neck disability on NDI correlated with autonomic dysfunction on objective signs (r=0.338) in I group. The decrease of daily activity was more significantly reduce on MIDAS in I group compare with II group.\u0000Conclusion. The combination of episodic migraine and cervicalgia in patients significantly reduces the daily activity rate on the MIDAS. The concomitant cervicalgia in patients with episodic migraine to contribute increase rates of state and trait anxiety and mild depressive symptoms and autonomic disturbance","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86526071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-30DOI: 10.15587/2519-4798.2022.252808
H. Chawla, A. Tyagi, Sandeep Dara, Aravindan U
The aim of the study was to estimate the stature from lower limb parameters in the north-west population of India and to know whether a significant correlation exists between the stature and various lower limb dimensions and to further derive regression formulae for estimation of stature from various lower limb segments. Materials and methods: the study was conducted on medical students age ranged between 18 to 28 years, which comes chiefly from north-west part of India. Only the subjects willing to participate in the study and given their written informed consent were included in the study group. The students having any obvious physical deformity were excluded from the study. Correlations between various lower limb parameters and stature were determined by using the Pearson’s correlation test. Sex-specific linear regression equations for stature estimation were developed using the lower limb measurements. The multiple regressions equations were produced based on various combinations of the parameters by stepwise regression analysis. Results: the Pearson’s correlation in combined group showed good correlations between lower limb parameters and stature. There was no statistically significant difference between known stature and estimated stature by using paired T-test for both right and left side in a group consisting of both sexes and in males (p>0.05). Conclusion: from the parameters, lower limb length and foot length had shown strong positive correlations with stature in the north-west Indian population
{"title":"Estimation of stature from lower limb measurements by regression analysis in north-west Indian population","authors":"H. Chawla, A. Tyagi, Sandeep Dara, Aravindan U","doi":"10.15587/2519-4798.2022.252808","DOIUrl":"https://doi.org/10.15587/2519-4798.2022.252808","url":null,"abstract":"The aim of the study was to estimate the stature from lower limb parameters in the north-west population of India and to know whether a significant correlation exists between the stature and various lower limb dimensions and to further derive regression formulae for estimation of stature from various lower limb segments.\u0000Materials and methods: the study was conducted on medical students age ranged between 18 to 28 years, which comes chiefly from north-west part of India. Only the subjects willing to participate in the study and given their written informed consent were included in the study group. The students having any obvious physical deformity were excluded from the study. Correlations between various lower limb parameters and stature were determined by using the Pearson’s correlation test. Sex-specific linear regression equations for stature estimation were developed using the lower limb measurements. The multiple regressions equations were produced based on various combinations of the parameters by stepwise regression analysis.\u0000Results: the Pearson’s correlation in combined group showed good correlations between lower limb parameters and stature. There was no statistically significant difference between known stature and estimated stature by using paired T-test for both right and left side in a group consisting of both sexes and in males (p>0.05).\u0000Conclusion: from the parameters, lower limb length and foot length had shown strong positive correlations with stature in the north-west Indian population","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"11953 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77006104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-30DOI: 10.15587/2519-4798.2022.253047
Irina Yakovtsova, O. Yanchevskyi, T. Chertenko, Andriy Kis, Andrii Oliyinyk
The aim: to find the optimal combination of immunohistochemical markers for differential diagnosis and prognosis of small cell lung cancer in small biopsy samples. Materials and methods. The tumor specimens were divided into 3 groups: 1) 25 biopsy samples of small cell lung cancer before treatment; 2) 25 samples of small cell lung cancer procured from autopsies of patients, who underwent chemotherapy; 3) 15 biopsy samples of other lung tumors histologically similar to SCLC. All tumor samples were formalin fixed and paraffin embedded (FFPE). Immunohistochemical study performed with 5 primary antibodies: CD56, p16ink4A, TTF-1, CD117, Ki-67. Results. TTF-1 was positive in all small cell lung cancer, lung adenocarcinomas and atypical carcinoids. Expression of CD56 was positive in 100 % of tumors from 1st group and 92 % of these tumors had more than 25 % of positive tumor cells. Expression of p16ink4A was significantly higher in 1st group than in the 3rd one (р<0,001). The stepwise logistic regression was used for finding the best markers for differential diagnosis of small cell lung cancer in small biopsy samples. The next combination of markers was chosen: TTF-1/CD56 (score 2–4)/p16 ink4A/CD117 (sensitivity – 80 %; specificity – 86.67 %; р<0,001) where “score 2–4” means expression of CD56 more than in 25 % tumor cells. Expression of Ki-67 was higher in the 2nd group compared with the 1st one (р<0,001). Conclusion. Evaluation of p16 expression can be used as additional marker for differential diagnosis of small cell lung cancer. The following combination of markers: TTF-1/CD56 (score2-4)/p16 ink4A/CD117 could be useful in diagnosis of small cell lung cancer in small biopsy samples and in the choice of targeted chemotherapy. The further study in paired tumor samples of small cell lung cancer before and after chemotherapy is required to prove the significance of changes in expression of Ki-67, CD56, CD117 and p16ink4A
{"title":"Immunohistochemical diagnosis and prognosis of small cell lung cancer: the search for new strategies","authors":"Irina Yakovtsova, O. Yanchevskyi, T. Chertenko, Andriy Kis, Andrii Oliyinyk","doi":"10.15587/2519-4798.2022.253047","DOIUrl":"https://doi.org/10.15587/2519-4798.2022.253047","url":null,"abstract":"The aim: to find the optimal combination of immunohistochemical markers for differential diagnosis and prognosis of small cell lung cancer in small biopsy samples. \u0000Materials and methods. The tumor specimens were divided into 3 groups: 1) 25 biopsy samples of small cell lung cancer before treatment; 2) 25 samples of small cell lung cancer procured from autopsies of patients, who underwent chemotherapy; 3) 15 biopsy samples of other lung tumors histologically similar to SCLC. All tumor samples were formalin fixed and paraffin embedded (FFPE). Immunohistochemical study performed with 5 primary antibodies: CD56, p16ink4A, TTF-1, CD117, Ki-67. \u0000Results. TTF-1 was positive in all small cell lung cancer, lung adenocarcinomas and atypical carcinoids. Expression of CD56 was positive in 100 % of tumors from 1st group and 92 % of these tumors had more than 25 % of positive tumor cells. Expression of p16ink4A was significantly higher in 1st group than in the 3rd one (р<0,001). The stepwise logistic regression was used for finding the best markers for differential diagnosis of small cell lung cancer in small biopsy samples. The next combination of markers was chosen: TTF-1/CD56 (score 2–4)/p16 ink4A/CD117 (sensitivity – 80 %; specificity – 86.67 %; р<0,001) where “score 2–4” means expression of CD56 more than in 25 % tumor cells. Expression of Ki-67 was higher in the 2nd group compared with the 1st one (р<0,001). \u0000Conclusion. Evaluation of p16 expression can be used as additional marker for differential diagnosis of small cell lung cancer. The following combination of markers: TTF-1/CD56 (score2-4)/p16 ink4A/CD117 could be useful in diagnosis of small cell lung cancer in small biopsy samples and in the choice of targeted chemotherapy. The further study in paired tumor samples of small cell lung cancer before and after chemotherapy is required to prove the significance of changes in expression of Ki-67, CD56, CD117 and p16ink4A","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91265040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-30DOI: 10.15587/2519-4798.2022.253073
O. Herasymova, O. Apanasenko
The aim: to improve the early diagnosis of cardiac arrhythmia and conduction disorders in children with gastroesophageal reflux by studying the predictor properties of indicators of undifferentiated connective tissue dysplasia in this category of patients. Materials and methods. We examined 56 children aged 8 to 18 years, with an average age of 14.93±2.62 years, of which 28 children with gastroesophageal reflux in combination with cardiac arrhythmias and conduction disorders were divided into group I, and 28 children with only gastroesophageal reflux without heart rhythm and conduction disturbances – into group II (control). All examined patients underwent clinical and instrumental studies (electrocardiography, 24-hour ECG Holter monitoring, esophagogastroduodenoscopy and PH-metry) and an assessment of the phenotypic signs of undifferentiated connective tissue dysplasia according to the criteria of T. Milkovskaya-Dimitrova and A. Karkashov. Results. When analyzing the predictor properties of indicators of undifferentiated connective tissue dysplasia for predicting the development of cardiac arrhythmias and conduction disorders in children with gastroesophageal reflux, it was found that scoliotic posture had very high predictor properties (I=5.99), а high growth (I=1.94) and a short upper lip (I=1.17) – high, dysplastic tooth growth (I=0 .6) – moderate, and an abnormal shape of the auricles – low ones (I=0.27). Other indicators of undifferentiated connective tissue dysplasia did not have predictive properties at all: joint hypermobility (I=0.22), total number of signs of undifferentiated connective tissue dysplasia (I=0.11), asthenic type of constitution (I=0.11), flat feet (I=0.08), refractive errors (I=0.05), deviated septum of nose (I=0.03), dilated bridge of the nose (I=0.01), short neck (I=0.01). The mean value of the prognostic significance of indicators of undifferentiated connective tissue dysplasia was high (І̅=1,99). Conclusions. It was found that the mean value of the prognostic significance of indicators of undifferentiated connective tissue dysplasia was high (І̅=1,99). It was determined that arrhythmias and cardiac conduction disturbances in children with gastroesophageal reflux are associated with the presence of a scoliotic posture (І=5,99), high growth (І=1,94), dysplastic growth of teeth (І=0,6); in the absence of a short upper lip (І=1,17) and an abnormal shape of the auricles (І=0,27)
{"title":"Predictor properties of indicators of undifferentiated connective tissue dysplasia in children with gastroesophageal reflux for prediction of the development of heart rhythm and conduction disorders","authors":"O. Herasymova, O. Apanasenko","doi":"10.15587/2519-4798.2022.253073","DOIUrl":"https://doi.org/10.15587/2519-4798.2022.253073","url":null,"abstract":"The aim: to improve the early diagnosis of cardiac arrhythmia and conduction disorders in children with gastroesophageal reflux by studying the predictor properties of indicators of undifferentiated connective tissue dysplasia in this category of patients. \u0000Materials and methods. We examined 56 children aged 8 to 18 years, with an average age of 14.93±2.62 years, of which 28 children with gastroesophageal reflux in combination with cardiac arrhythmias and conduction disorders were divided into group I, and 28 children with only gastroesophageal reflux without heart rhythm and conduction disturbances – into group II (control). All examined patients underwent clinical and instrumental studies (electrocardiography, 24-hour ECG Holter monitoring, esophagogastroduodenoscopy and PH-metry) and an assessment of the phenotypic signs of undifferentiated connective tissue dysplasia according to the criteria of T. Milkovskaya-Dimitrova and A. Karkashov. \u0000Results. When analyzing the predictor properties of indicators of undifferentiated connective tissue dysplasia for predicting the development of cardiac arrhythmias and conduction disorders in children with gastroesophageal reflux, it was found that scoliotic posture had very high predictor properties (I=5.99), а high growth (I=1.94) and a short upper lip (I=1.17) – high, dysplastic tooth growth (I=0 .6) – moderate, and an abnormal shape of the auricles – low ones (I=0.27). \u0000Other indicators of undifferentiated connective tissue dysplasia did not have predictive properties at all: joint hypermobility (I=0.22), total number of signs of undifferentiated connective tissue dysplasia (I=0.11), asthenic type of constitution (I=0.11), flat feet (I=0.08), refractive errors (I=0.05), deviated septum of nose (I=0.03), dilated bridge of the nose (I=0.01), short neck (I=0.01). \u0000The mean value of the prognostic significance of indicators of undifferentiated connective tissue dysplasia was high (І̅=1,99). \u0000Conclusions. It was found that the mean value of the prognostic significance of indicators of undifferentiated connective tissue dysplasia was high (І̅=1,99). \u0000It was determined that arrhythmias and cardiac conduction disturbances in children with gastroesophageal reflux are associated with the presence of a scoliotic posture (І=5,99), high growth (І=1,94), dysplastic growth of teeth (І=0,6); in the absence of a short upper lip (І=1,17) and an abnormal shape of the auricles (І=0,27)","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84448882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-30DOI: 10.15587/2519-4798.2022.252941
O. Proshchenko, I. Ventskivska, Y. Vitovsky, S. Markitanyuk
The aim of the research – to identify violations of quality of life after hysterectomy with opportunistic salpingectomy, considering different approaches to surgery. Materials and methods. Quality of life assessments of hysterectomy with opportunistic salpingectomy for uterine fibroids were performed in 160 women of reproductive age, who were divided into two groups: I – 90 patients with vaginal access, and II – 70 patients with abdominal access. The control group included 50 women with asymptomatic fibroids of reproductive age. The diagnostic algorithm included a physical examination, ultrasound examination of the pelvic organs, assessment of urogenital dysfunction questionnaire using the MOS SF-36 questionnaire; to identify signs of vegetative changes in Wayne, to assess general fatigue, physical and mental fatigue MFI-20 was performed using a standardized POP-Q system. Results. The leading violations of quality-of-life parameters are general somatic symptoms 107 (66.9±6.0 %), psycho-emotional disorders 89 (55.6±6.7 %), genitourinary and sexual disorders 39 (24.4±3.0 %). Among the most common somatic ones – complaints of headaches, edema and fluctuations in blood pressure. The dominance of asthenic, anxiety and depressive disorders among psycho-emotional disorders has been established. The diagnosis of “organic asthenic disorder” was established in 47 (52.2±9.7 %) and 39 (55.7±7.3 %), respectively, in the groups of examined patients. Vaginal hysterectomy causes more increase in the proportion of urogenital disorders 25 27.7±8.3 %) compared to control – 7 (14.0±4.8 %) (p<0.05). An ultrasound examination showed a 2.25-fold increase in ovarian volume one month after the hysterectomy, and a reduction in ovarian tissue volume in both study groups 2 years after surgery. Conclusions. Hysterectomy with opportunistic salpingectomy affects the parameters of quality of life. The leading violations of quality-of-life parameters are general somatic symptoms, psycho-emotional disorders without statistically significant difference in groups, but the indicators are better in group I. The minimal effect on ovarian function and size was determined – 2 years after surgery, there was a decrease in ovarian tissue volume in both study groups, but statistically significant – in the second group (3.12±0.7 cm3, p<0.05) against the data control (5.82±1.7 cm3). Although the results showed a more frequent manifestation of pelvic floor descent in vaginal access, quality of life parameters were higher in these patients. Given its safety, efficiency and cost-effectiveness, it is advisable to choose it as a method of choice
{"title":"Assessment of quality of life after hysterectomy with opportunistіс salpingeсtomy with uterine myoma by vaginal and abdominal access","authors":"O. Proshchenko, I. Ventskivska, Y. Vitovsky, S. Markitanyuk","doi":"10.15587/2519-4798.2022.252941","DOIUrl":"https://doi.org/10.15587/2519-4798.2022.252941","url":null,"abstract":"The aim of the research – to identify violations of quality of life after hysterectomy with opportunistic salpingectomy, considering different approaches to surgery. \u0000Materials and methods. Quality of life assessments of hysterectomy with opportunistic salpingectomy for uterine fibroids were performed in 160 women of reproductive age, who were divided into two groups: I – 90 patients with vaginal access, and II – 70 patients with abdominal access. The control group included 50 women with asymptomatic fibroids of reproductive age. The diagnostic algorithm included a physical examination, ultrasound examination of the pelvic organs, assessment of urogenital dysfunction questionnaire using the MOS SF-36 questionnaire; to identify signs of vegetative changes in Wayne, to assess general fatigue, physical and mental fatigue MFI-20 was performed using a standardized POP-Q system. \u0000Results. The leading violations of quality-of-life parameters are general somatic symptoms 107 (66.9±6.0 %), psycho-emotional disorders 89 (55.6±6.7 %), genitourinary and sexual disorders 39 (24.4±3.0 %). Among the most common somatic ones – complaints of headaches, edema and fluctuations in blood pressure. The dominance of asthenic, anxiety and depressive disorders among psycho-emotional disorders has been established. The diagnosis of “organic asthenic disorder” was established in 47 (52.2±9.7 %) and 39 (55.7±7.3 %), respectively, in the groups of examined patients. Vaginal hysterectomy causes more increase in the proportion of urogenital disorders 25 27.7±8.3 %) compared to control – 7 (14.0±4.8 %) (p<0.05). An ultrasound examination showed a 2.25-fold increase in ovarian volume one month after the hysterectomy, and a reduction in ovarian tissue volume in both study groups 2 years after surgery. \u0000Conclusions. Hysterectomy with opportunistic salpingectomy affects the parameters of quality of life. The leading violations of quality-of-life parameters are general somatic symptoms, psycho-emotional disorders without statistically significant difference in groups, but the indicators are better in group I. The minimal effect on ovarian function and size was determined – 2 years after surgery, there was a decrease in ovarian tissue volume in both study groups, but statistically significant – in the second group (3.12±0.7 cm3, p<0.05) against the data control (5.82±1.7 cm3). Although the results showed a more frequent manifestation of pelvic floor descent in vaginal access, quality of life parameters were higher in these patients. Given its safety, efficiency and cost-effectiveness, it is advisable to choose it as a method of choice","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90973012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-30DOI: 10.15587/2519-4798.2021.247973
Yanina Morozova, A. Pavlov
The aim of the research. To study the kidneys functional state when using different regimens of intraoperative fluid therapy in high cardiac risk patients during abdominal surgery. Materials and methods. 142 patients who underwent abdominal surgical interventions mainly for oncoproctological diseases of the gastrointestinal tract, aged over 50 years old and with a history of stable coronary heart disease were divided into four groups depending on the way of intraoperative fluid therapy, which was performed according to two regimens: restrictive (R) and liberal (L). R1 (n=36) with rate of intraoperative fluid therapy 3–5 ml/ kg/ h, R2 (n=35) patients received 5–8 ml/kg/h during surgery, L1 (n=35) with intraoperative fluid rate of 8–11 ml/kg/h and L2 (n=36) – more than 11 ml/kg/h intraoperatively. The study of the functional state of the kidneys included the determination of such indicators as urea, creatinine, diuresis, the degree of AKI according to KDIGO in two stages of the study – before surgery and 18–24 hours after. Results. The greatest tendency to develop acute kidney injury was observed in R1 subgroup with a restrictive intraoperative fluid therapy regimen, and the smallest in L1 subgroup with a relatively liberal regimen. The R2 and L2 subgroups took an intermediate place in the number of renal complications. A high tendency to develop renal dysfunction in patients of R1 subgroup was associated with circulatory hypokinesia and a moderate decrease of renal perfusion. Conclusions. The study found that restriction of infusion in R1 subgroup contributed to the development of renal dysfunction in almost half of the patients. First of all it was associated with a decrease of GFR in conditions of circulatory hypokinesia, which is larger in R1 subgroup and amounted to about 35 %. The safest regimens of intraoperative fluid therapy in relation to renal function in the perioperative period were relatively liberal (subgroup L1) and relatively restrictive (subgroup R2), which provided the least number of complications in patients
{"title":"Kidney`s functional state assessment when using different regimens of intraoperative fluid therapy","authors":"Yanina Morozova, A. Pavlov","doi":"10.15587/2519-4798.2021.247973","DOIUrl":"https://doi.org/10.15587/2519-4798.2021.247973","url":null,"abstract":"The aim of the research. To study the kidneys functional state when using different regimens of intraoperative fluid therapy in high cardiac risk patients during abdominal surgery. \u0000Materials and methods. 142 patients who underwent abdominal surgical interventions mainly for oncoproctological diseases of the gastrointestinal tract, aged over 50 years old and with a history of stable coronary heart disease were divided into four groups depending on the way of intraoperative fluid therapy, which was performed according to two regimens: restrictive (R) and liberal (L). R1 (n=36) with rate of intraoperative fluid therapy 3–5 ml/ kg/ h, R2 (n=35) patients received 5–8 ml/kg/h during surgery, L1 (n=35) with intraoperative fluid rate of 8–11 ml/kg/h and L2 (n=36) – more than 11 ml/kg/h intraoperatively. The study of the functional state of the kidneys included the determination of such indicators as urea, creatinine, diuresis, the degree of AKI according to KDIGO in two stages of the study – before surgery and 18–24 hours after. \u0000Results. The greatest tendency to develop acute kidney injury was observed in R1 subgroup with a restrictive intraoperative fluid therapy regimen, and the smallest in L1 subgroup with a relatively liberal regimen. The R2 and L2 subgroups took an intermediate place in the number of renal complications. A high tendency to develop renal dysfunction in patients of R1 subgroup was associated with circulatory hypokinesia and a moderate decrease of renal perfusion. \u0000Conclusions. The study found that restriction of infusion in R1 subgroup contributed to the development of renal dysfunction in almost half of the patients. First of all it was associated with a decrease of GFR in conditions of circulatory hypokinesia, which is larger in R1 subgroup and amounted to about 35 %. The safest regimens of intraoperative fluid therapy in relation to renal function in the perioperative period were relatively liberal (subgroup L1) and relatively restrictive (subgroup R2), which provided the least number of complications in patients","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81856438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-30DOI: 10.15587/2519-4798.2021.249957
Y. Dogra, Rama Thakur, B. Dhiman
The aim of the present study was to investigate the socio-demographic and obstetric profile of pregnant women, seeking medical termination of pregnancy in accordance with the Medical Termination of Pregnancy (MTP) Act and the reasons for undergoing termination of pregnancy in the tertiary care center of the hilly region of Northern India and to further review the amendments in the Medical Termination of Pregnancy Act 1971 along with its future implications in legalizing abortions in India. Materials and Methods: A registry-based retrospective study was carried out among pregnant women, attending the gynecologic outpatient department for termination of pregnancy at the tertiary care teaching hospital and the referral center for Himalayan foothills in Northern India. The records of women, seeking termination of pregnancy during a 1-year period between October 2020 and September 2021, were reviewed and information on their demographic and obstetric profile, reason for undergoing termination of pregnancy, and acceptance of contraception, following termination of pregnancy was recorded in the data sheet. The information obtained was analyzed using SPSS version 20 (IBM, Chicago, USA) for descriptive statistics. Results: A total of 400 pregnant women underwent Medical Termination of Pregnancy between October 2020 and September 2021. 30.5 % (122/400) women between 26–30 years of age underwent termination of pregnancy, followed by 27.3 % women aged between 31–35 years. Social reasons for termination of pregnancy were more evident in women aged 26 years and above. 84.09 % pregnancies were terminated in the second trimester (>12 weeks) on eugenic ground, while 65.01 % pregnancies were terminated in the first trimester (6–12 weeks) on social grounds. Only 7.75 % (31/400) women opted for sterilization or family planning after MTP, out of which the majority opted for temporary methods of contraception. Conclusion: We conclude from the results of the present study that women in the peak reproductive age (26–30 years) are more likely to seek pregnancy termination and this group of women needs to be the focus of contraceptive counseling and family planning services. Timely ultrasound scans by an expert sonologist may be a step forward towards lowering the rates of late pregnancy termination. There is a need to educate women to avail and use contraceptive methods in an effective manner and to make them aware of utilizing sterilization services, once they complete their families to avoid unwanted pregnancies.
本研究的目的是调查根据《医疗终止妊娠法》寻求医疗终止妊娠的孕妇的社会人口和产科情况，以及在印度北部丘陵地区的三级保健中心进行终止妊娠的原因，并进一步审查《1971年医疗终止妊娠法》的修正案及其对印度堕胎合法化的未来影响。材料和方法:在印度北部喜马拉雅山麓三级保健教学医院妇科门诊终止妊娠的孕妇中进行了一项基于登记的回顾性研究。对2020年10月至2021年9月期间寻求终止妊娠的妇女的记录进行了审查，并在数据表中记录了其人口统计和产科概况、终止妊娠的原因以及终止妊娠后接受避孕措施的信息。所得信息使用SPSS version 20 (IBM, Chicago, USA)进行描述性统计分析。结果:在2020年10月至2021年9月期间，共有400名孕妇接受了医学终止妊娠。30.5%(122/400)的26-30岁妇女终止妊娠，其次是27.3%的31-35岁妇女。社会原因终止妊娠在26岁及以上女性中更为明显。84.09%的妊娠终止于妊娠中期(>12周)，65.01%的妊娠终止于妊娠早期(6-12周)。只有7.75%(31/400)的妇女在中期计划生育后选择绝育或计划生育，其中大多数人选择临时避孕方法。结论:根据本研究结果，生育高峰期(26-30岁)的女性更容易寻求终止妊娠，这一群体需要成为避孕咨询和计划生育服务的重点。由超声专家及时进行超声扫描可能是降低晚期妊娠终止率的一步。有必要教育妇女以有效的方式利用和使用避孕方法，并使她们认识到，一旦她们成家，就应利用绝育服务，以避免意外怀孕。
{"title":"Profile of abortion seekers in the tertiary center of northern hills with review of medical termination of pregnancy act in India","authors":"Y. Dogra, Rama Thakur, B. Dhiman","doi":"10.15587/2519-4798.2021.249957","DOIUrl":"https://doi.org/10.15587/2519-4798.2021.249957","url":null,"abstract":"The aim of the present study was to investigate the socio-demographic and obstetric profile of pregnant women, seeking medical termination of pregnancy in accordance with the Medical Termination of Pregnancy (MTP) Act and the reasons for undergoing termination of pregnancy in the tertiary care center of the hilly region of Northern India and to further review the amendments in the Medical Termination of Pregnancy Act 1971 along with its future implications in legalizing abortions in India. \u0000Materials and Methods: A registry-based retrospective study was carried out among pregnant women, attending the gynecologic outpatient department for termination of pregnancy at the tertiary care teaching hospital and the referral center for Himalayan foothills in Northern India. The records of women, seeking termination of pregnancy during a 1-year period between October 2020 and September 2021, were reviewed and information on their demographic and obstetric profile, reason for undergoing termination of pregnancy, and acceptance of contraception, following termination of pregnancy was recorded in the data sheet. The information obtained was analyzed using SPSS version 20 (IBM, Chicago, USA) for descriptive statistics. \u0000Results: A total of 400 pregnant women underwent Medical Termination of Pregnancy between October 2020 and September 2021. 30.5 % (122/400) women between 26–30 years of age underwent termination of pregnancy, followed by 27.3 % women aged between 31–35 years. Social reasons for termination of pregnancy were more evident in women aged 26 years and above. 84.09 % pregnancies were terminated in the second trimester (>12 weeks) on eugenic ground, while 65.01 % pregnancies were terminated in the first trimester (6–12 weeks) on social grounds. Only 7.75 % (31/400) women opted for sterilization or family planning after MTP, out of which the majority opted for temporary methods of contraception. \u0000Conclusion: We conclude from the results of the present study that women in the peak reproductive age (26–30 years) are more likely to seek pregnancy termination and this group of women needs to be the focus of contraceptive counseling and family planning services. Timely ultrasound scans by an expert sonologist may be a step forward towards lowering the rates of late pregnancy termination. There is a need to educate women to avail and use contraceptive methods in an effective manner and to make them aware of utilizing sterilization services, once they complete their families to avoid unwanted pregnancies.","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"84 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90301690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-30DOI: 10.15587/2519-4798.2021.250144
Gunay Adalat Valiyeva
Liver damage in diabetes mellitus is of particular interest, since this factor significantly affects the course of the disease, the level of compensation and prognosis of the underlying disease. The aim. To study the effect of complex treatment using ursosan on the functional state of the hepatobiliary system in patients with diabetes mellitus. Materials and methods. The study included 30 patients with type 1 diabetes mellitus and 48 patients with type 2 diabetes. According to the duration of diabetes, patients were divided into three subgroups: a) up to five years; b) 5–10 years; c) more than 10 years. The number of patients was: 1a group – 13, 1b group – 10, 1c group – 7 people; Group 2a – 23, 2b group – 13, 2c group – 10 people. The control group consisted of 23 apparently healthy people. Ursosan was prescribed at a dose of 10-12 mg per 1 kg of body per day for 6 months. Clinical laboratory and instrumental research methods were used to study the functional state of the liver and gallbladder. Research results. After the course of treatment with Ursosan, patients with diabetes mellitus showed normalization of protein, pigment, enzymatic metabolism and, to a lesser extent, lipid metabolism in the liver, which led to an improvement in cellular metabolism and redox processes, providing a stable course of diabetes. Conclusions. A 6-month course of treatment with Ursosan in diabetic patients promotes long-term diabetes compensation. Patients during treatment have a decrease in cytolysis syndrome indicators (alanine aminotransferase (AlAT), aspartate aminotransferase (AsAT), lactate dehydrogenesis (LDH)) by about 1.5 times in all 3 indicators compared to the indicators before treatment. The same trend was observed in terms of gamma-glutamine transferase (GGT) and alkaline phosphatase (ALP)
{"title":"Influence of complex treatment on the functional state of the hepatobiliary system in patients with diabetes mellitus","authors":"Gunay Adalat Valiyeva","doi":"10.15587/2519-4798.2021.250144","DOIUrl":"https://doi.org/10.15587/2519-4798.2021.250144","url":null,"abstract":"Liver damage in diabetes mellitus is of particular interest, since this factor significantly affects the course of the disease, the level of compensation and prognosis of the underlying disease. The aim. To study the effect of complex treatment using ursosan on the functional state of the hepatobiliary system in patients with diabetes mellitus. Materials and methods. The study included 30 patients with type 1 diabetes mellitus and 48 patients with type 2 diabetes. According to the duration of diabetes, patients were divided into three subgroups: a) up to five years; b) 5–10 years; c) more than 10 years. The number of patients was: 1a group – 13, 1b group – 10, 1c group – 7 people; Group 2a – 23, 2b group – 13, 2c group – 10 people. The control group consisted of 23 apparently healthy people. Ursosan was prescribed at a dose of 10-12 mg per 1 kg of body per day for 6 months. Clinical laboratory and instrumental research methods were used to study the functional state of the liver and gallbladder. Research results. After the course of treatment with Ursosan, patients with diabetes mellitus showed normalization of protein, pigment, enzymatic metabolism and, to a lesser extent, lipid metabolism in the liver, which led to an improvement in cellular metabolism and redox processes, providing a stable course of diabetes. Conclusions. A 6-month course of treatment with Ursosan in diabetic patients promotes long-term diabetes compensation. Patients during treatment have a decrease in cytolysis syndrome indicators (alanine aminotransferase (AlAT), aspartate aminotransferase (AsAT), lactate dehydrogenesis (LDH)) by about 1.5 times in all 3 indicators compared to the indicators before treatment. The same trend was observed in terms of gamma-glutamine transferase (GGT) and alkaline phosphatase (ALP)","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87428209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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