Pub Date : 2023-03-31DOI: 10.15587/2519-4798.2023.282363
Y. Saldan
Age-related macular degeneration (AMD) is now recognized as a complex genetic condition in which any number of genes influence a person's susceptibility to developing the disorder. Earlier studies of genetics, in addition to population-based genetic epidemiologic approaches, strongly emphasized the importance of genetics in AMD. Although the degree of heritability and the number of genes are related, the behavioural and genetic variability of the disease remains unclear, but access to modern diagnostic methods, ophthalmological and molecular genetics, expands our understanding of the mechanisms of its development and progression. One of the main problems of ophthalmological research in the coming years will be to determine the genetic cause of AMD. The use of various genetic methods provides the best chance of determining the function of one or more genes in the pathophysiology of this condition. The aim of this article is to conduct an analysis of the current literature to understand the pathogenesis of AMD at the molecular level and to provide the opportunity to establish and investigate new treatment methods, as well as to provide a treatment strategy that combines nutritional, environmental, and pharmacological methods to reduce the effect of genetic susceptibility and preserve vision. Materials and methods - sources of information in the form of scientific articles, research works and monographs were selected for the analytical review of the literature. Databases such as PubMed, Google Scholar, Scopus and Web Of Science were used. Research results - in the analytical review of modern domestic and foreign literature, it was determined that the use of various genetic methods provides the best chances to determine the function of one or more genes in the pathophysiology of age-related macular degeneration. Conclusions - one of the main problems of ophthalmological research in the coming years will be to determine the genetic cause of AMD. The use of various genetic methods provides the best chance of determining the function of one or more genes in the pathophysiology of this condition. The goals are to identify people at high risk of developing AMD before they develop symptoms or serious pathology, to understand the pathogenesis of AMD at the molecular level and to enable the establishment and investigation of new treatments, as well as to provide a treatment strategy that combines nutritional, environmental, and pharmacological methods to reduce the effect of genetic susceptibility and preserve vision
年龄相关性黄斑变性(AMD)现在被认为是一种复杂的遗传疾病，其中任何数量的基因都会影响一个人对这种疾病的易感性。早期的遗传学研究，除了基于人群的遗传流行病学方法，强烈强调遗传在AMD中的重要性。虽然遗传程度和基因数量相关，但该病的行为和遗传变异性仍不清楚，但现代诊断方法，眼科和分子遗传学，扩大了我们对其发展和进展机制的理解。未来几年眼科研究的主要问题之一将是确定AMD的遗传原因。使用各种遗传方法提供了最好的机会来确定一个或多个基因在这种情况的病理生理中的功能。本文的目的是对现有文献进行分析，从分子水平上了解AMD的发病机制，为建立和研究新的治疗方法提供机会，并提供一种结合营养、环境和药物方法的治疗策略，以减少遗传易感性的影响，保护视力。材料和方法-以科学文章，研究工作和专著的形式的信息来源被选择为文献的分析性审查。使用了PubMed、b谷歌Scholar、Scopus和Web Of Science等数据库。研究结果——在对现代国内外文献的分析综述中，确定使用各种遗传学方法为确定年龄相关性黄斑变性病理生理中一个或多个基因的功能提供了最佳机会。结论-未来几年眼科研究的主要问题之一将是确定AMD的遗传原因。使用各种遗传方法提供了最好的机会来确定一个或多个基因在这种情况的病理生理中的功能。目的是在AMD出现症状或严重病理之前识别出AMD的高危人群，在分子水平上了解AMD的发病机制，并建立和研究新的治疗方法，以及提供一种结合营养、环境和药物方法的治疗策略，以减少遗传易感性的影响，并保持视力
{"title":"The modern view of the state of the problem of age-macular degeneration, its connection with genetics","authors":"Y. Saldan","doi":"10.15587/2519-4798.2023.282363","DOIUrl":"https://doi.org/10.15587/2519-4798.2023.282363","url":null,"abstract":"Age-related macular degeneration (AMD) is now recognized as a complex genetic condition in which any number of genes influence a person's susceptibility to developing the disorder. Earlier studies of genetics, in addition to population-based genetic epidemiologic approaches, strongly emphasized the importance of genetics in AMD. Although the degree of heritability and the number of genes are related, the behavioural and genetic variability of the disease remains unclear, but access to modern diagnostic methods, ophthalmological and molecular genetics, expands our understanding of the mechanisms of its development and progression. One of the main problems of ophthalmological research in the coming years will be to determine the genetic cause of AMD. The use of various genetic methods provides the best chance of determining the function of one or more genes in the pathophysiology of this condition. \u0000The aim of this article is to conduct an analysis of the current literature to understand the pathogenesis of AMD at the molecular level and to provide the opportunity to establish and investigate new treatment methods, as well as to provide a treatment strategy that combines nutritional, environmental, and pharmacological methods to reduce the effect of genetic susceptibility and preserve vision. \u0000Materials and methods - sources of information in the form of scientific articles, research works and monographs were selected for the analytical review of the literature. Databases such as PubMed, Google Scholar, Scopus and Web Of Science were used. \u0000Research results - in the analytical review of modern domestic and foreign literature, it was determined that the use of various genetic methods provides the best chances to determine the function of one or more genes in the pathophysiology of age-related macular degeneration. \u0000Conclusions - one of the main problems of ophthalmological research in the coming years will be to determine the genetic cause of AMD. The use of various genetic methods provides the best chance of determining the function of one or more genes in the pathophysiology of this condition. The goals are to identify people at high risk of developing AMD before they develop symptoms or serious pathology, to understand the pathogenesis of AMD at the molecular level and to enable the establishment and investigation of new treatments, as well as to provide a treatment strategy that combines nutritional, environmental, and pharmacological methods to reduce the effect of genetic susceptibility and preserve vision","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86510789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-14DOI: 10.15587/2519-4798.2023.273589
M. Sliepchenko, O. Olkhovska
The aim. To identify the influence of the latent form of Epstein-Barr virus infection on the clinical picture, parameters of clinical blood analysis and cytokine response of children with rotavirus gastroenteritis. Materials and methods. 56 children were examined. Of them, 33 children (group 1) had no background infection with herpesviruses, and 23 patients (group 2) suffered from rotavirus gastroenteritis against the background of Epstein-Barr virus (EBV) infection. The patients were comparable in terms of sex, age and disease severity. Differences at p <0.05 were considered statistically significant. Results. The analysis of the obtained data showed that the latent form of EBV infection affects the clinical picture, indicators of clinical blood analysis and the reaction of serum cytokines of children with rotavirus gastroenteritis. Сonclusions. A comparative analysis revealed that a latent form of herpesvirus infection in children with rotavirus gastroenteritis is associated with lower temperature reaction and a lower frequency of vomiting in the acute period of the disease against the background of longer persistence of fever, diarrhoea and catarrhal syndromes. On the part of the investigated laboratory indicators, the presence of EBV infection is characterized by a lower level of haemoglobin (р = 0,013) against a higher content of neutrophils (p = 0.002), eosinophils (p = 0.033) and monocytes (p < 0.001) in the acute period of RVI, and a significantly higher content of eosinophils (p = 0.001) and monocytes (p < 0.001) against the background of a lower level of the relative content of lymphocytes compared to patients of Group 1 in the period of early convalescence. Changes in the cytokine response in children with mixed infection are characterized by a significantly lower concentration of IL-1β at the onset of RVI and a higher content of IL-4 and TNF-α throughout the disease compared to children with mono-RVI
{"title":"The influence of the Epstein-Barr virus on paraclinical indicators and cytokine levels in children with rotavirus gastroenteritis","authors":"M. Sliepchenko, O. Olkhovska","doi":"10.15587/2519-4798.2023.273589","DOIUrl":"https://doi.org/10.15587/2519-4798.2023.273589","url":null,"abstract":"The aim. To identify the influence of the latent form of Epstein-Barr virus infection on the clinical picture, parameters of clinical blood analysis and cytokine response of children with rotavirus gastroenteritis. \u0000Materials and methods. 56 children were examined. Of them, 33 children (group 1) had no background infection with herpesviruses, and 23 patients (group 2) suffered from rotavirus gastroenteritis against the background of Epstein-Barr virus (EBV) infection. The patients were comparable in terms of sex, age and disease severity. Differences at p <0.05 were considered statistically significant. \u0000Results. The analysis of the obtained data showed that the latent form of EBV infection affects the clinical picture, indicators of clinical blood analysis and the reaction of serum cytokines of children with rotavirus gastroenteritis. \u0000Сonclusions. A comparative analysis revealed that a latent form of herpesvirus infection in children with rotavirus gastroenteritis is associated with lower temperature reaction and a lower frequency of vomiting in the acute period of the disease against the background of longer persistence of fever, diarrhoea and catarrhal syndromes. On the part of the investigated laboratory indicators, the presence of EBV infection is characterized by a lower level of haemoglobin (р = 0,013) against a higher content of neutrophils (p = 0.002), eosinophils (p = 0.033) and monocytes (p < 0.001) in the acute period of RVI, and a significantly higher content of eosinophils (p = 0.001) and monocytes (p < 0.001) against the background of a lower level of the relative content of lymphocytes compared to patients of Group 1 in the period of early convalescence. Changes in the cytokine response in children with mixed infection are characterized by a significantly lower concentration of IL-1β at the onset of RVI and a higher content of IL-4 and TNF-α throughout the disease compared to children with mono-RVI","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"101 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77364289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-31DOI: 10.15587/2519-4798.2023.275612
T. Loskutova, A. Petulko
The aim: to study the distribution and influence of coagulation factor gene polymorphisms and endothelial dysfunction on the development of recurrent pregnancy loss. Materials and methods: a prospective case-control study included 109 pregnant women in the 1st trimester with habitual miscarriage and 34 conditionally healthy pregnant women with an uncomplicated obstetrical anamnesis without risk factors for miscarriage. Genetic polymorphisms of coagulation and fibrinolysis factors (1691 G→A FVL, 20210 G→A prothrombin, 675 5G/4G PAI-1, 455 G→A fibrinogen β), as well as endothelial dysfunctions (192 Q→R PON-1, 677 C → T MTHFR) were investigated using allele-specific polymerase chain reaction. Results: Pathological polymorphisms of the genes of the hemostasis system and endothelial dysfunction play a significant role in the development of miscarriage, namely such pathological genotypes as 1691 GA of factor V Leiden - increases the risk by 5.3 times (95 % CI 1.5-18.5), 20210 GA of prothrombin - by 26.47 times (1.6-445.7), 675 4G/4G PAI-1 - by 7, 5 times (1.7-33.79), -455AA fibrinogen β - 9.7 times (1.3-74.16), 677 CT MTHFR - 2.6 times (1.0-6.2), 677 TT MTHFR - 21.7 times (1.3-368.6). Multigenic forms of thrombophilia predominate in the majority of patients with miscarriage and account for 76.1 % (p<0.001, OR=12.31, 95 % CI 4.8-31.55). It was determined that the simultaneous presence of two pathological polymorphisms increases the risk of miscarriage by 3.88 times (OR 3.38; 95 % CI 1.26-9.97), and three ones - more than 2.5 times (OR 2.66; 95 % CI 1.02-7.19). Conclusions: the course of pregnancy against the background of pathological polymorphisms of the genes of the hemostasis system and endothelial dysfunction significantly increases the risk of habitual miscarriage, which should be considered when planning a pregnancy in women with habitual miscarriage
{"title":"Determining the risk of miscarriage in genetic forms of thrombophilia","authors":"T. Loskutova, A. Petulko","doi":"10.15587/2519-4798.2023.275612","DOIUrl":"https://doi.org/10.15587/2519-4798.2023.275612","url":null,"abstract":"The aim: to study the distribution and influence of coagulation factor gene polymorphisms and endothelial dysfunction on the development of recurrent pregnancy loss. \u0000Materials and methods: a prospective case-control study included 109 pregnant women in the 1st trimester with habitual miscarriage and 34 conditionally healthy pregnant women with an uncomplicated obstetrical anamnesis without risk factors for miscarriage. Genetic polymorphisms of coagulation and fibrinolysis factors (1691 G→A FVL, 20210 G→A prothrombin, 675 5G/4G PAI-1, 455 G→A fibrinogen β), as well as endothelial dysfunctions (192 Q→R PON-1, 677 C → T MTHFR) were investigated using allele-specific polymerase chain reaction. \u0000Results: Pathological polymorphisms of the genes of the hemostasis system and endothelial dysfunction play a significant role in the development of miscarriage, namely such pathological genotypes as 1691 GA of factor V Leiden - increases the risk by 5.3 times (95 % CI 1.5-18.5), 20210 GA of prothrombin - by 26.47 times (1.6-445.7), 675 4G/4G PAI-1 - by 7, 5 times (1.7-33.79), -455AA fibrinogen β - 9.7 times (1.3-74.16), 677 CT MTHFR - 2.6 times (1.0-6.2), 677 TT MTHFR - 21.7 times (1.3-368.6). Multigenic forms of thrombophilia predominate in the majority of patients with miscarriage and account for 76.1 % (p<0.001, OR=12.31, 95 % CI 4.8-31.55). It was determined that the simultaneous presence of two pathological polymorphisms increases the risk of miscarriage by 3.88 times (OR 3.38; 95 % CI 1.26-9.97), and three ones - more than 2.5 times (OR 2.66; 95 % CI 1.02-7.19). \u0000Conclusions: the course of pregnancy against the background of pathological polymorphisms of the genes of the hemostasis system and endothelial dysfunction significantly increases the risk of habitual miscarriage, which should be considered when planning a pregnancy in women with habitual miscarriage","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80317693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-31DOI: 10.15587/2519-4798.2023.275503
R. Blagoveshchensky, I. Tuchkina
The purpose of the study was to elaborate on a prognostic model for predicting the development of abnormal uterine bleeding in women of reproductive age with accompanying extragenital disorders based on mathematical methods. Materials and methods. The study, which was in 2019-2022, involved 100 women of reproductive age with AUB and accompanying extragenital disorders under observation, who made up the main group. The control group comprised 50 women of reproductive age undergoing medical checkups. On the basis of 23 diagnostic indicators, the most informative ones were mathematically selected for the prognosis of AUB in women with extragenital abnormalities. Results and their discussion. The prognosis of the risk of developing AUB in women of reproductive age with extragenital disorders was carried out on a double scale (0 – low probability, 1 – high probability). The search for diagnostically informative factors involved a set of 23 working indicators that were investigated in the examined patients using four levels of the risk scale. In order to solve this issue, the factors that have the greatest importance in the formation of the prognosis were selected using discriminant analysis methods, and a corresponding mathematical model was created. The classification functions made it possible to enter the practical plane and form rules for assessing the presence/absence of the risk of developing AUB in patients of reproductive age with extragenital disorders. The corresponding expressions are the following equations: NP = BAS ART*75.57+FSH*2.96+prolac*0.02+estrad*0.02-40.78 PP = BAS ART*105.35+FSH*0.79+prolac*0.1+estrad*0.08-114.49, where NP is a negative prognosis, PP is a positive prognosis. If NP > PP, then the most likely prognosis is the absence of AUB in the patient; otherwise, if PP > NP – there is an increased risk of AUB. Conclusion. Pulsation index in the basal arteries of the uterus, FSH, prolactin and estrogens are prognostically significant indicators for predicting the risk of abnormal uterine bleeding in patients of reproductive age with extragenital disorders. The above formula, obtained from the conducted discriminant analysis, makes it possible to predict bleeding in a specific patient
本研究的目的是建立一种基于数学方法的预测育龄妇女异常子宫出血伴外阴疾病发展的预后模型。材料和方法。该研究于2019年至2022年进行，涉及100名育龄妇女，她们患有AUB并伴有外阴疾病，她们构成了主要群体。对照组由50名接受体检的育龄妇女组成。在23项诊断指标的基础上，以数学方式选择最具信息量的指标，用于诊断伴有外阴异常的女性AUB的预后。结果和讨论。对伴有外阴疾病的育龄妇女发生AUB风险的预后进行双评分(0 -低概率，1 -高概率)。对诊断信息因素的搜索涉及一组23个工作指标，在检查的患者中使用四个级别的风险量表进行调查。为了解决这一问题，采用判别分析方法选取在预后形成过程中最重要的因素，并建立相应的数学模型。分类功能可以进入实用层面，形成评估育龄伴外阴疾病患者是否存在AUB风险的规则。对应的表达式为:NP = BAS ART*75.57+FSH*2.96+prolac*0.02+estrad*0.02-40.78 PP = BAS ART*105.35+FSH*0.79+prolac*0.1+estrad*0.08-114.49，其中NP为阴性预后，PP为阳性预后。如果NP > PP，那么最可能的预后是患者无AUB;反之，如果PP > NP -则AUB的风险增加。结论。子宫基底动脉搏动指数、卵泡刺激素、催乳素、雌激素是预测育龄伴外阴疾病患者子宫异常出血风险的重要预后指标。上述公式是通过判别分析得出的，可以预测特定患者的出血情况
{"title":"Prognosis of abnormal uterine bleeding in women of reproductive age with extragenital disorders","authors":"R. Blagoveshchensky, I. Tuchkina","doi":"10.15587/2519-4798.2023.275503","DOIUrl":"https://doi.org/10.15587/2519-4798.2023.275503","url":null,"abstract":"The purpose of the study was to elaborate on a prognostic model for predicting the development of abnormal uterine bleeding in women of reproductive age with accompanying extragenital disorders based on mathematical methods. \u0000Materials and methods. The study, which was in 2019-2022, involved 100 women of reproductive age with AUB and accompanying extragenital disorders under observation, who made up the main group. The control group comprised 50 women of reproductive age undergoing medical checkups. On the basis of 23 diagnostic indicators, the most informative ones were mathematically selected for the prognosis of AUB in women with extragenital abnormalities. \u0000Results and their discussion. The prognosis of the risk of developing AUB in women of reproductive age with extragenital disorders was carried out on a double scale (0 – low probability, 1 – high probability). The search for diagnostically informative factors involved a set of 23 working indicators that were investigated in the examined patients using four levels of the risk scale. In order to solve this issue, the factors that have the greatest importance in the formation of the prognosis were selected using discriminant analysis methods, and a corresponding mathematical model was created. The classification functions made it possible to enter the practical plane and form rules for assessing the presence/absence of the risk of developing AUB in patients of reproductive age with extragenital disorders. The corresponding expressions are the following equations: \u0000NP = BAS ART*75.57+FSH*2.96+prolac*0.02+estrad*0.02-40.78 \u0000PP = BAS ART*105.35+FSH*0.79+prolac*0.1+estrad*0.08-114.49, \u0000where NP is a negative prognosis, PP is a positive prognosis. \u0000If NP > PP, then the most likely prognosis is the absence of AUB in the patient; otherwise, if PP > NP – there is an increased risk of AUB. \u0000Conclusion. Pulsation index in the basal arteries of the uterus, FSH, prolactin and estrogens are prognostically significant indicators for predicting the risk of abnormal uterine bleeding in patients of reproductive age with extragenital disorders. The above formula, obtained from the conducted discriminant analysis, makes it possible to predict bleeding in a specific patient","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81729528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-31DOI: 10.15587/2519-4798.2023.275390
Arpit Deriya, Deepti Arora, A. Malhotra, S. Chandak, Vaibhav Goyal, Paurush Jain
Sonoelastography is a comparatively new and developing technology in the field of salivary gland imaging. Nevertheless, it has the potential to distinguish between various types of lesions by calculating the degree of strain-related deformation under the externally applied force. With this background, the present study was undertaken to evaluate the role of sonoelastography in characterising salivary gland lesions as benign or malignant. The aim: To evaluate and characterize salivary Gland lesions on the Gray scale and Colour doppler ultrasonography and sonoelastography and to correlate these findings with the clinico-pathological diagnosis. Methodology: This prospective cross-sectional study was conducted in the Department of Radiodiagnosis, Teerthanker Mahaveer Medical College & Research Centre, Moradabad (U.P.), from Aug 2021 to Nov 2022. All patients referred to the radiology department for imaging with clinical suspicion of having salivary gland lesions were enrolled in the study and evaluated on the SIEMENS ACUSON S3000 machine. Gray scale USG was done first to assess various morphological features of lesions, and then a Doppler assessment was done to determine vascularity within the lesion. Subsequently, real-time strain elastography (eSie touch) was performed to assess the tissue stiffness. The elastogram image of the detected lesions was evaluated using colour coding ranging from blue (soft) through green (intermediate/average hardness) and red (hard). After strain elastography, shear wave elastography of the lesion was also performed using Virtual Touch Quantification (VTQ) and Virtual Touch Imaging Quantification (VTIQ) software. The sonographic findings were correlated with histopathological diagnosis. The acquired data were subjected to statistical analysis using the software SPSS version 20. Sensitivity, specificity, PPV and NPV were calculated for conventional ultrasound techniques alone & in combination with elastography. Results: Out of the 50 salivary gland lesions included in the study, 44 (88 %) were benign, whereas 6 (12 %) were malignant on cytology. The age of the study population ranged from 16 to 75 years, with a mean age of 38.82 years. Pleomorphic adenoma (60 %) was the most frequent lesion, followed by Warthin's tumour (28 %). The Conventional USG showed 66.67 %, sensitivity, 52.27 %, specificity, 16.00 %, PPV, 92.00 % NPV and 54.00 % accuracy in differentiating benign from malignant lesions while USG- Elastography combined showed higher diagnostic performance with 83.33 %, sensitivity, 79.55 %, specificity, 35.71 % PPV, 97.22 % NPV and 80.00 %, accuracy. The specific cut-off scores for the sonoelastography score, eSie touch, VTQ, and VTIQ were also determined to diagnose a lesion as malignant or benign, and the difference was found to be statistically significant. Conclusions: Sonoelastography alone cannot be solely relied upon to distinguish between malignant & benign salivary gland abnormalities. Howeve
{"title":"Sonoelastographic evaluation of salivary gland lesions with clinicopathological association","authors":"Arpit Deriya, Deepti Arora, A. Malhotra, S. Chandak, Vaibhav Goyal, Paurush Jain","doi":"10.15587/2519-4798.2023.275390","DOIUrl":"https://doi.org/10.15587/2519-4798.2023.275390","url":null,"abstract":"Sonoelastography is a comparatively new and developing technology in the field of salivary gland imaging. Nevertheless, it has the potential to distinguish between various types of lesions by calculating the degree of strain-related deformation under the externally applied force. With this background, the present study was undertaken to evaluate the role of sonoelastography in characterising salivary gland lesions as benign or malignant. \u0000The aim: To evaluate and characterize salivary Gland lesions on the Gray scale and Colour doppler ultrasonography and sonoelastography and to correlate these findings with the clinico-pathological diagnosis. \u0000Methodology: This prospective cross-sectional study was conducted in the Department of Radiodiagnosis, Teerthanker Mahaveer Medical College & Research Centre, Moradabad (U.P.), from Aug 2021 to Nov 2022. All patients referred to the radiology department for imaging with clinical suspicion of having salivary gland lesions were enrolled in the study and evaluated on the SIEMENS ACUSON S3000 machine. Gray scale USG was done first to assess various morphological features of lesions, and then a Doppler assessment was done to determine vascularity within the lesion. Subsequently, real-time strain elastography (eSie touch) was performed to assess the tissue stiffness. The elastogram image of the detected lesions was evaluated using colour coding ranging from blue (soft) through green (intermediate/average hardness) and red (hard). After strain elastography, shear wave elastography of the lesion was also performed using Virtual Touch Quantification (VTQ) and Virtual Touch Imaging Quantification (VTIQ) software. The sonographic findings were correlated with histopathological diagnosis. The acquired data were subjected to statistical analysis using the software SPSS version 20. Sensitivity, specificity, PPV and NPV were calculated for conventional ultrasound techniques alone & in combination with elastography. \u0000Results: Out of the 50 salivary gland lesions included in the study, 44 (88 %) were benign, whereas 6 (12 %) were malignant on cytology. The age of the study population ranged from 16 to 75 years, with a mean age of 38.82 years. Pleomorphic adenoma (60 %) was the most frequent lesion, followed by Warthin's tumour (28 %). The Conventional USG showed 66.67 %, sensitivity, 52.27 %, specificity, 16.00 %, PPV, 92.00 % NPV and 54.00 % accuracy in differentiating benign from malignant lesions while USG- Elastography combined showed higher diagnostic performance with 83.33 %, sensitivity, 79.55 %, specificity, 35.71 % PPV, 97.22 % NPV and 80.00 %, accuracy. The specific cut-off scores for the sonoelastography score, eSie touch, VTQ, and VTIQ were also determined to diagnose a lesion as malignant or benign, and the difference was found to be statistically significant. \u0000Conclusions: Sonoelastography alone cannot be solely relied upon to distinguish between malignant & benign salivary gland abnormalities. Howeve","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83632638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-31DOI: 10.15587/2519-4798.2023.274476
Wajahat Ahmad, A. Najmi, N. Wani, S. Wani, S. Banday, Shahida Nasreen
Concurrent chemoradiation (CCRT) is considered the standard of care in locally advanced and inoperable carcinoma oesophagus patients. However, the majority of these patients have residual disease after completion of CCRT, and there are no definitive treatment guidelines for the management of the residual disease. Reports on consolidation chemotherapy for patients with oesophagal cancer after definitive CCRT are rare and have shown mixed results. The aim of this study was to see the effects of consolidation chemotherapy in patients of CCRT who had residual disease and were not surgical candidates and also monitor its side effects. Material and methods: It was a prospective interventional protocol over 2 years where patients received 4 cycles of consolidation chemotherapy post-CCRT. These patients were followed after completion of chemotherapy for response, toxicity and survival. Results: 45 patients were initially enrolled for the study, histopathologically proven carcinoma of the oesophagus, out of which 30 patients finally received the full course of treatment and were available for final assessment. After consolidation chemotherapy, 23 (76.7 %) patients had a complete response, 3 (10 %) had a partial response, and 4 (13.3 %) had stable disease. There was no progression of the disease during treatment. The overall treatment protocol was well tolerated by all the patients. There were no grade IV toxicities. On follow-up till the compilation of this data, 23 (76.6 %) of the patients were alive, and 7 (23.3 %) died (disease-related events). Out of these 7 patients, 4 patients had a local failure, and 3 patients developed distant metastasis in the form of brain and liver metastasis. Conclusion: Consolidation chemotherapy after concurrent chemoradiation in locally advanced, inoperable carcinoma oesophagus is a well-tolerable protocol with high chances of complete response rates
{"title":"Study of consolidation chemotherapy after definitive chemoradiation in locally advanced carcinoma esophagus in a tertiary care hospital","authors":"Wajahat Ahmad, A. Najmi, N. Wani, S. Wani, S. Banday, Shahida Nasreen","doi":"10.15587/2519-4798.2023.274476","DOIUrl":"https://doi.org/10.15587/2519-4798.2023.274476","url":null,"abstract":"Concurrent chemoradiation (CCRT) is considered the standard of care in locally advanced and inoperable carcinoma oesophagus patients. However, the majority of these patients have residual disease after completion of CCRT, and there are no definitive treatment guidelines for the management of the residual disease. Reports on consolidation chemotherapy for patients with oesophagal cancer after definitive CCRT are rare and have shown mixed results.\u0000The aim of this study was to see the effects of consolidation chemotherapy in patients of CCRT who had residual disease and were not surgical candidates and also monitor its side effects.\u0000Material and methods: It was a prospective interventional protocol over 2 years where patients received 4 cycles of consolidation chemotherapy post-CCRT. These patients were followed after completion of chemotherapy for response, toxicity and survival.\u0000Results: 45 patients were initially enrolled for the study, histopathologically proven carcinoma of the oesophagus, out of which 30 patients finally received the full course of treatment and were available for final assessment. After consolidation chemotherapy, 23 (76.7 %) patients had a complete response, 3 (10 %) had a partial response, and 4 (13.3 %) had stable disease. There was no progression of the disease during treatment. The overall treatment protocol was well tolerated by all the patients. There were no grade IV toxicities. On follow-up till the compilation of this data, 23 (76.6 %) of the patients were alive, and 7 (23.3 %) died (disease-related events). Out of these 7 patients, 4 patients had a local failure, and 3 patients developed distant metastasis in the form of brain and liver metastasis.\u0000Conclusion: Consolidation chemotherapy after concurrent chemoradiation in locally advanced, inoperable carcinoma oesophagus is a well-tolerable protocol with high chances of complete response rates","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"100 8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83330084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aims: The purpose of this study was to evaluate and compare the anterior and posterior corneal surface parameters, keratoconus indices, thickness profile data, and data from enhanced elevation maps of keratoconus and normal corneas using Combined Placido-Schiempflug imaging-based topography, and to determine the sensitivity and specificity of these parameters in discriminating keratoconus from normal eyes. Materials and methods: A retrospective comparative observational study of 100 normal eyes and 100 keratoconus eyes was done from April 2014 to May 2015 at MM Joshi Eye Institute, Hubli, Karnataka. We evaluated and compared the anterior and posterior corneal surface parameters, keratoconus indices, thickness profile data, and data from enhanced elevation maps of keratoconus and normal corneas using Combined Placido-Scheimpflug Imaging based Topography to determine the sensitivity and specificity of these parameters in discriminating keratoconus from normal eyes. Results: Keratoconus indices (Sif, Sib, BCV-f, BCV-b, KVf, KVb, CCT, MinCT) showed Excellent AUROC values followed by K- steep in posterior curvature at 3 mm, 5 mm followed by K- steep in anterior curvature and other parameters in discriminating Normal from Keratoconus-Suspect eyes. Elevation indices- BCV-f, BCV-b, CCT, Min-CT, K-steep & K-flat in anterior and posterior curvature in 3 mm, 5 mm, 7 mm, and CV were significant in discriminating normal from mild keratoconus. All parameters except ACV and ICA were significant in discriminating normal from moderate keratoconus. All parameters were significant in discriminating normal from severe keratoconus eyes. Morphological indices were significant in differentiating mild, moderate and severe keratoconus. Conclusion: Many parameters were statistically significant between keratoconus and normal eyes compared with early keratoconus eyes. The topography and corneal aberration results in this study are promising for detecting ectatic corneas. In our study, thickness indices-CCT, MinCT, Abberometry indices- BCVf, BCVb and keratometry in steep meridian at posterior curvature had the highest AUC scores in differentiating normal from sub-clinical keratoconus. Elevation indices- Rbf-f, Rbf-b, thickness indices- CCT, MinCT, aberrometry indices, and keratometry-steep in anterior & posterior curvature had the highest AUC scores in differentiating moderate and severe keratoconus
{"title":"Comparison of anterior segment parameters in normal and keratoconus eyes using combined placido-disk schiempflug imaging-based topography","authors":"Madhuri Kurakula, Pasumarthi Pavani Yelamanchili, Mannam Gitanjali, Kotagiri Srawanthy","doi":"10.15587/2519-4798.2022.270264","DOIUrl":"https://doi.org/10.15587/2519-4798.2022.270264","url":null,"abstract":"The aims: The purpose of this study was to evaluate and compare the anterior and posterior corneal surface parameters, keratoconus indices, thickness profile data, and data from enhanced elevation maps of keratoconus and normal corneas using Combined Placido-Schiempflug imaging-based topography, and to determine the sensitivity and specificity of these parameters in discriminating keratoconus from normal eyes. \u0000Materials and methods: A retrospective comparative observational study of 100 normal eyes and 100 keratoconus eyes was done from April 2014 to May 2015 at MM Joshi Eye Institute, Hubli, Karnataka. We evaluated and compared the anterior and posterior corneal surface parameters, keratoconus indices, thickness profile data, and data from enhanced elevation maps of keratoconus and normal corneas using Combined Placido-Scheimpflug Imaging based Topography to determine the sensitivity and specificity of these parameters in discriminating keratoconus from normal eyes. \u0000Results: Keratoconus indices (Sif, Sib, BCV-f, BCV-b, KVf, KVb, CCT, MinCT) showed Excellent AUROC values followed by K- steep in posterior curvature at 3 mm, 5 mm followed by K- steep in anterior curvature and other parameters in discriminating Normal from Keratoconus-Suspect eyes. Elevation indices- BCV-f, BCV-b, CCT, Min-CT, K-steep & K-flat in anterior and posterior curvature in 3 mm, 5 mm, 7 mm, and CV were significant in discriminating normal from mild keratoconus. All parameters except ACV and ICA were significant in discriminating normal from moderate keratoconus. All parameters were significant in discriminating normal from severe keratoconus eyes. Morphological indices were significant in differentiating mild, moderate and severe keratoconus. \u0000Conclusion: Many parameters were statistically significant between keratoconus and normal eyes compared with early keratoconus eyes. \u0000The topography and corneal aberration results in this study are promising for detecting ectatic corneas. In our study, thickness indices-CCT, MinCT, Abberometry indices- BCVf, BCVb and keratometry in steep meridian at posterior curvature had the highest AUC scores in differentiating normal from sub-clinical keratoconus. \u0000Elevation indices- Rbf-f, Rbf-b, thickness indices- CCT, MinCT, aberrometry indices, and keratometry-steep in anterior & posterior curvature had the highest AUC scores in differentiating moderate and severe keratoconus","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87067014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-30DOI: 10.15587/2519-4798.2022.269499
K. Madhavi, K. Reddy
The face is the most prominent part of the body. Facial blemishes and disorders directly reflect a person's physical appearance, cosmesis and self-image. They may contribute to dysmorphism and even lead to depression in susceptible individuals, especially women. Early identification and management of facial skin disorders are therefore important. The aim: To study the clinical pattern and epidemiological determinants of facial dermatoses among females above 10 years. Methods: The study was carried out at Mediciti Medical sciences from 2014 to 2017; institutional ethical clearance was obtained (dated 7/2//2015 with registration number FWA00002684) A total of 500 female patients with facial dermatoses, aged 10 to 85 years, were enrolled in this cross-sectional study for 18 months. Detailed history and clinical examination findings were recorded in a structured proforma. Patients with sexually transmitted infections (STIs) were excluded. In addition, woods lamp examination, skin scrapings for potassium hydroxide mount, skin biopsy and other relevant investigations were done as required. Results: A total of 500 patients were enrolled. The majority were in the 4th and 5th decades. Pigmentary dermatoses were highest, melasma predominating. Immunobullous dermatoses formed the smallest group. Occupation-wise, the majority were agricultural labourers. Many dermatoses, especially melasma, were related to occupation and lifestyle with photo-aggravation, cosmetics use and stress. Conclusion: This study assessed the pattern of facial dermatoses among the female clientele of this institution. Hyperpigmentary dermatoses, especially melasma, emerged as the most common dermatosis for which treatment was sought. This study assessed the pattern and epidemiologic determinants of facial dermatoses in female patients in a rural Tertiary hospital at Ghanpur, Telangana. Melasma was the most frequent dermatosis for which treatment was sought. Larger population-based studies would determine the actual socioeconomic burden of the problem
脸是身体最突出的部分。面部瑕疵和失调直接反映了一个人的外表、外貌和自我形象。它们可能会导致畸形，甚至导致易感个体，尤其是女性抑郁。因此，面部皮肤疾病的早期识别和治疗非常重要。目的:探讨10岁以上女性面部皮肤病的临床特点及流行病学影响因素。方法:研究于2014 - 2017年在Mediciti Medical sciences进行;获得了机构伦理许可(日期为2015年7月2日，注册号为FWA00002684)。共有500名女性面部皮肤病患者，年龄在10至85岁之间，被纳入这项横断面研究，为期18个月。详细的病史和临床检查结果记录在一个结构化的形式。排除性传播感染(STIs)患者。此外，还按要求进行了木灯检查、皮肤刮擦氢氧化钾mount、皮肤活检等相关检查。结果:共纳入500例患者。大多数发生在40年代和50年代。色素性皮肤病发生率最高，以黄褐斑为主。免疫大疱性皮肤病是最小的群体。就职业而言，大多数是农业劳动者。许多皮肤病，特别是黄褐斑，与职业和生活方式有关，与光加重、化妆品使用和压力有关。结论:本研究评估了该机构女性客户面部皮肤病的类型。色素沉着性皮肤病，特别是黄褐斑，成为最常见的皮肤病，寻求治疗。本研究评估了特伦甘纳邦甘普尔农村三级医院女性患者面部皮肤病的模式和流行病学决定因素。黄褐斑是寻求治疗的最常见皮肤病。更大规模的以人口为基础的研究将确定该问题的实际社会经济负担
{"title":"High hCG levels as a cut-off to guide medical management of ectopic pregnancy: our experience","authors":"K. Madhavi, K. Reddy","doi":"10.15587/2519-4798.2022.269499","DOIUrl":"https://doi.org/10.15587/2519-4798.2022.269499","url":null,"abstract":"The face is the most prominent part of the body. Facial blemishes and disorders directly reflect a person's physical appearance, cosmesis and self-image. They may contribute to dysmorphism and even lead to depression in susceptible individuals, especially women. Early identification and management of facial skin disorders are therefore important.\u0000The aim: To study the clinical pattern and epidemiological determinants of facial dermatoses among females above 10 years.\u0000Methods: The study was carried out at Mediciti Medical sciences from 2014 to 2017; institutional ethical clearance was obtained (dated 7/2//2015 with registration number FWA00002684)\u0000A total of 500 female patients with facial dermatoses, aged 10 to 85 years, were enrolled in this cross-sectional study for 18 months. Detailed history and clinical examination findings were recorded in a structured proforma. Patients with sexually transmitted infections (STIs) were excluded. In addition, woods lamp examination, skin scrapings for potassium hydroxide mount, skin biopsy and other relevant investigations were done as required.\u0000Results: A total of 500 patients were enrolled. The majority were in the 4th and 5th decades. Pigmentary dermatoses were highest, melasma predominating. Immunobullous dermatoses formed the smallest group. Occupation-wise, the majority were agricultural labourers. Many dermatoses, especially melasma, were related to occupation and lifestyle with photo-aggravation, cosmetics use and stress.\u0000Conclusion: This study assessed the pattern of facial dermatoses among the female clientele of this institution. Hyperpigmentary dermatoses, especially melasma, emerged as the most common dermatosis for which treatment was sought. This study assessed the pattern and epidemiologic determinants of facial dermatoses in female patients in a rural Tertiary hospital at Ghanpur, Telangana. Melasma was the most frequent dermatosis for which treatment was sought. Larger population-based studies would determine the actual socioeconomic burden of the problem","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"97 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77332646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-30DOI: 10.15587/2519-4798.2022.268523
Victoriia Iablonska, L. Kholopov, O. Khyzhnyak, Viktoriia Batashova-Halinska
The aim of the study is to establish the effectiveness of treatment of severe angina pectoris in patients with hyperuricemia, taking into consideration the peculiarities of the course of coronary artery disease (CAD) in wartime, using ranolazine – a selective inhibitor of the late sodium flow in combined pharmacotherapy. Materials and methods. We studied the anti-anginal effect of ranolazine in 14 patients with CAD, stable angina pectoris III-IV functional class (FC), hyperuricemia and arterial hypertension (AH) during 6 months of the 2022 year. The effectiveness of the study drug on the clinical course of angina pectoris was assessed by questionnaire and clinical examination after three months of treatment. The results. At the end of the second week of ranolazine use, angina attacks at rest, which were registered before the start of the observation, stopped in all patients with angina pectoris III FC and 50 % with angina pectoris IV FC. In 78.6 %, the number of angina attacks and the use of nitrates decreased by more than 2 times; 21.4 % no longer had angina attacks. At the end of the first month, anginal attacks were not observed in all patients with angina pectoris III FC and 50 % with angina pectoris FC IV. In 2 patients with angina pectoris IV FC (50 %), anginal attacks continued to be registered during physical exertion and emotional stress, but no more than once a week. At the same time, there were no angina attacks at rest. The same results were obtained during the survey of patients at the end of three months of observation. Conclusions. Ranolazine is an effective component of anti-anginal therapy, significantly affecting the patient's quality of life. Therefore, we can recommend ranolazine for patients with hyperuricemia in angina attacks that persist with insufficient effectiveness of zasic therapy with first-line drugs, especially during military conflicts
{"title":"The effectiveness of cytoprotection in the treatment of stable angina in patients with arterial hypertension and hyperuricemia, taking into account the peculiarities of the course of coronary artery disease in wartime","authors":"Victoriia Iablonska, L. Kholopov, O. Khyzhnyak, Viktoriia Batashova-Halinska","doi":"10.15587/2519-4798.2022.268523","DOIUrl":"https://doi.org/10.15587/2519-4798.2022.268523","url":null,"abstract":"The aim of the study is to establish the effectiveness of treatment of severe angina pectoris in patients with hyperuricemia, taking into consideration the peculiarities of the course of coronary artery disease (CAD) in wartime, using ranolazine – a selective inhibitor of the late sodium flow in combined pharmacotherapy. \u0000Materials and methods. We studied the anti-anginal effect of ranolazine in 14 patients with CAD, stable angina pectoris III-IV functional class (FC), hyperuricemia and arterial hypertension (AH) during 6 months of the 2022 year. The effectiveness of the study drug on the clinical course of angina pectoris was assessed by questionnaire and clinical examination after three months of treatment. \u0000The results. At the end of the second week of ranolazine use, angina attacks at rest, which were registered before the start of the observation, stopped in all patients with angina pectoris III FC and 50 % with angina pectoris IV FC. In 78.6 %, the number of angina attacks and the use of nitrates decreased by more than 2 times; 21.4 % no longer had angina attacks. \u0000At the end of the first month, anginal attacks were not observed in all patients with angina pectoris III FC and 50 % with angina pectoris FC IV. In 2 patients with angina pectoris IV FC (50 %), anginal attacks continued to be registered during physical exertion and emotional stress, but no more than once a week. At the same time, there were no angina attacks at rest. The same results were obtained during the survey of patients at the end of three months of observation. \u0000Conclusions. Ranolazine is an effective component of anti-anginal therapy, significantly affecting the patient's quality of life. Therefore, we can recommend ranolazine for patients with hyperuricemia in angina attacks that persist with insufficient effectiveness of zasic therapy with first-line drugs, especially during military conflicts","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84733652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-30DOI: 10.15587/2519-4798.2022.268941
Nallamilli Spandana Reddy, J. Upadhyaya, Col. G K Prasad
The face is the most prominent part of the body. Facial blemishes and disorders directly reflect a person's physical appearance, cosmesis and self-image. They may contribute to dysmorphism and even lead to depression in susceptible individuals, especially women. Early identification and management of facial skin disorders are therefore important. The aim: To study the clinical pattern and epidemiological determinants of facial dermatoses among females above 10 years. Methods: This cross-sectional study was conducted among female patients with facial dermatoses, with informed consent, at a rural tertiary hospital for 18 months. Results: A total of 500 patients were enrolled. The majority were in the 4th and 5th decades. Pigmentary dermatoses were highest, melasma predominating. Immunobullous dermatoses formed the smallest group. Occupation-wise, the majority were agricultural labourers. Many dermatoses, especially melasma, were related to occupation and lifestyle with photo-aggravation, cosmetics use and stress. Conclusion: This study assessed the pattern of facial dermatoses among the female clientele of this institution. Hyperpigmentary dermatoses, especially melasma, emerged as the most common dermatosis for which treatment was sought
{"title":"A clinical-epidemiological study of facial dermatoses in women","authors":"Nallamilli Spandana Reddy, J. Upadhyaya, Col. G K Prasad","doi":"10.15587/2519-4798.2022.268941","DOIUrl":"https://doi.org/10.15587/2519-4798.2022.268941","url":null,"abstract":"The face is the most prominent part of the body. Facial blemishes and disorders directly reflect a person's physical appearance, cosmesis and self-image. They may contribute to dysmorphism and even lead to depression in susceptible individuals, especially women. Early identification and management of facial skin disorders are therefore important. The aim: To study the clinical pattern and epidemiological determinants of facial dermatoses among females above 10 years. Methods: This cross-sectional study was conducted among female patients with facial dermatoses, with informed consent, at a rural tertiary hospital for 18 months. Results: A total of 500 patients were enrolled. The majority were in the 4th and 5th decades. Pigmentary dermatoses were highest, melasma predominating. Immunobullous dermatoses formed the smallest group. Occupation-wise, the majority were agricultural labourers. Many dermatoses, especially melasma, were related to occupation and lifestyle with photo-aggravation, cosmetics use and stress. Conclusion: This study assessed the pattern of facial dermatoses among the female clientele of this institution. Hyperpigmentary dermatoses, especially melasma, emerged as the most common dermatosis for which treatment was sought","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80284831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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