Seminars in arthritis and rheumatism最新文献

英文中文

Psychometric properties of patient-reported outcomes measurement information system (PROMIS) fixed short forms in Juvenile Myositis

IF 4.6 2区医学 Q1 RHEUMATOLOGY

Seminars in arthritis and rheumatism

Pub Date : 2025-02-01 DOI: 10.1016/j.semarthrit.2025.152649

Kaveh Ardalan , Mariana C. Marques , David Cella , Megan L. Curran , Elizabeth L. Gray , Jungwha Lee , Kyle J. Fahey , Madison L. Wolfe , Lauren M. Pachman , Rowland W. Chang

Objectives

Assess reliability and validity of Patient-Reported Outcomes Measurement Information System (PROMIS) pediatric self-report and parent-proxy report fixed short forms in juvenile myositis (JM).

Methods

Children with JM (8–17yo) and parents of 5–17 yo JM patients completed PROMIS measures (Physical Function, Pain Interference, Fatigue, Emotional Distress), PedsQL Generic Core scales and Rheumatology Module (PedsQL-GC/-RM). Internal consistency reliability was assessed via Cronbach's alpha. Patient-parent agreement was assessed via intraclass correlations (ICC). Concurrent and construct validity were assessed via Spearman's correlations between PROMIS versus PedsQL-GC/-RM and clinical/lab data respectively. Known-groups validity was assessed by comparing PROMIS T-scores between clinically distinct JM patients.

Results

We enrolled 75 JM participants, with 57 administered self-report and all 75 administered parent-proxy report measures per participant age. PROMIS measures were feasible (>96% completion), with high internal consistency reliability (Cronbach's alpha >0.8). Patient-parent assessments demonstrated moderate agreement (ICC >0.5) for Mobility, Upper Extremity, and Fatigue domains, and smaller correlations (ICC 0.41–0.47) as expected for Pain Interference, Depressive Symptoms, and Anxiety. Concurrent validity was demonstrated by moderate correlation (Spearman's rho >0.5) for all but 1 hypothesized relationships of PROMIS and PedsQL-GC/-RM domains. Although low disease activity and small sample size limited statistical power, construct validity and known-groups validity were demonstrable for multiple PROMIS pediatric self-report and parent-proxy report measures.

Conclusion

PROMIS measures show evidence of reliability and validity in JM. Child and parent reports differ sufficiently to suggest both should be collected. PROMIS measures can be considered for clinical and research use in JM.

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引用次数: 0

Accrual of organ damage and one-year mortality in systemic sclerosis: A prospective observational study 系统性硬化症的器官损伤累积和一年死亡率：一项前瞻性观察研究。

IF 4.6 2区医学 Q1 RHEUMATOLOGY

Seminars in arthritis and rheumatism

Pub Date : 2025-02-01 DOI: 10.1016/j.semarthrit.2024.152604

Laura Cano-García , Aimara García-Studer , Sara Manrique-Arija , Fernando Ortiz-Márquez , Rocío Redondo-Rodríguez , Paula Borregón-Garrido , Natalia Mena-Vázquez , Antonio Fernández-Nebro

Objective

To determine cumulative organ damage in patients with systemic sclerosis (SSc) according to the Scleroderma Clinical Trials Consortium Damage Index (SCTC-DI), assess 1-year mortality risk, and identify associated factors.

Methods

A prospective, single-center study was conducted in a cohort of patients with SSc. A cross-sectional study and a 12-month longitudinal follow-up were carried out. The main outcomes were SCTC-DI and all-cause mortality at 12 months. Other variables included clinical-laboratory data, modified Rodnan Skin Score (mRSS), EuroQoL 5-D (EQ-5D), and Steinbrocker functional status. Multivariate models were used to study factors associated with SCTC-DI and mortality.

Results

The study population comprised 75 patients (97.3% females) with a mean age of 59.6 years. The median (IQR) of the SCTC-DI was 4(6), and only 4 (5.3%) patients had severe SCTC-DI (≥13). The factors associated with SCTC-DI were disease duration (β=0.276), mRSS (β=0.287), C-reactive protein (CRP) concentration (β=0.311), and EQ-5D (β= –0.207). After 1 year of follow-up, 4 patients had died. The factors associated with mortality at 12 months (OR [95% CI]) were baseline SCTC-DI ≥13 (44.5 [1.6–1237.9]; p = 0.025) and visual analog scale (VAS) of the EQ-5D (0.9 [0.8–0.9]; p = 0.018).

Conclusions

The SCTC DI can prove useful in clinical practice for assessing disease progression and short-term mortality risk. Cumulative damage was associated with disease duration, mRSS, CRP concentration, and a decline in EQ-5D, while the risk of death at 12 months was primarily associated with high SCTC-DI and low EQ-5D VAS. New studies are needed to improve assessment tools in patients with SSc.

目的：根据硬皮病临床试验联盟损伤指数（SCTC-DI）确定系统性硬化症（SSc）患者的累积器官损伤，评估1年死亡风险，并确定相关因素。方法：在SSc患者队列中进行了一项前瞻性、单中心研究。进行了横断面研究和12个月的纵向随访。主要结局是SCTC-DI和12个月时的全因死亡率。其他变量包括临床-实验室数据、改良罗德曼皮肤评分（mRSS）、EuroQoL 5-D （EQ-5D）和Steinbrocker功能状态。多变量模型用于研究与SCTC-DI和死亡率相关的因素。结果：研究人群包括75例患者，其中97.3%为女性，平均年龄59.6岁。SCTC-DI的中位（IQR）为4(6)，只有4（5.3%）例患者为重度SCTC-DI（≥13）。与SCTC-DI相关的因素为病程（β=0.276）、mRSS （β=0.287）、c反应蛋白（CRP）浓度（β=0.311）和EQ-5D （β= -0.207）。随访1年后，4例患者死亡。与12个月死亡率相关的因素（OR [95% CI]）是：基线SCTC-DI≥13 (44.5 [1.6-1237.9]；p = 0.025)， EQ-5D的视觉模拟评分（VAS）为0.9 [0.8-0.9]；P = 0.018)。结论：SCTC DI在临床实践中可用于评估疾病进展和短期死亡风险。累积损伤与病程、mRSS、CRP浓度和EQ-5D下降相关，而12个月时的死亡风险主要与高SCTC-DI和低EQ-5D VAS相关。需要新的研究来改进SSc患者的评估工具。

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引用次数: 0

Value of ultrasound-assessed dactylitis in the early diagnosis of psoriatic arthritis 超声评估指炎在银屑病关节炎早期诊断中的价值。

IF 4.6 2区医学 Q1 RHEUMATOLOGY

Seminars in arthritis and rheumatism

Pub Date : 2025-02-01 DOI: 10.1016/j.semarthrit.2024.152612

Otto Olivas-Vergara , Lina Martínez-Estupiñán , Fredeswinda Romero-Bueno , Olga Sánchez-Pernaute , Javier R. Godo , María del Carmen Fariña-Sabaris , Belén Ruffin-Vicente , Agustina Criado-Alcazar , Pablo E. Borges , Sheila Recuero-Díaz , Andrea Alvear-Torres , Amalia Gil , Antía García-Fernández , Ana Elena Hoyo-Fernández , M. Belén Ortega-Trompeta , M. Isabel Sánchez-Barba-Izquierdo , Gabriel Herrero-Beaumont , Raquel Largo , Esperanza Naredo

Purpose

The primary objective of this prospective, longitudinal, observational, single-centre study was to evaluate the association between ultrasound-assessed lesions of dactylitis and the diagnosis of psoriatic arthritis (PsA) in patients with psoriasis (PsO) and hand arthralgia.

Methods

We included adult patients diagnosed with PsO with hand arthralgia, with or without other musculoskeletal complaints. They were clinically assessed at baseline, 6 and 12 months by a rheumatologist blinded to the ultrasound findings. At baseline, patients underwent a B-mode (BM) and power Doppler (PD) ultrasound assessment by other rheumatologist blinded to clinical data. The ultrasound evaluation included bilateral detection and scoring of synovitis (3 joints, 0-3), tenosynovitis (flexor tendons, 0-3), enthesitis (9 sites, 0-1), peri‑extensor tendon inflammation (PETI) (0-3), and subcutaneous tissue inflammation (SCTI) (0-3) in the 2nd-5th fingers.

Results

Seventy patients [44 women; mean (SD) age 51 (12.4) years] were included, of whom 64 completed the study. Of these, 15 (23.4 %) were diagnosed with PsA during the 12-month follow-up period. At finger level, the presence and amount of baseline BM and PD synovitis, BM tenosynovitis, BM and PD enthesitis, and BM and PD PETI were associated with PsA diagnosis (p < .05). A predictive model including two variables, presence of PD synovitis and BM enthesitis, was found to predict PsA diagnosis (χ2 = 35.38; p < .001) with an accuracy of 89.1 %, a sensitivity of 86.7 % and a specificity of 89.8 %.

Conclusions

Ultrasound-assessed lesions of dactylitis were associated with a diagnosis of PsA and the short-term development of PsA in patients with PsO and hand arthralgia.

目的：这项前瞻性、纵向、观察性、单中心研究的主要目的是评估超声评估的银屑病（PsO）和手关节痛患者指炎病变与银屑病关节炎（PsA）诊断之间的关系。方法：我们纳入了诊断为PsO并伴有手关节痛的成年患者，伴有或不伴有其他肌肉骨骼疾病。他们在基线、6个月和12个月时由一名不知道超声结果的风湿病学家进行临床评估。在基线时，患者接受b型（BM）和功率多普勒（PD）超声评估，由其他不了解临床数据的风湿病学家进行。超声评估包括双侧2 -5指滑膜炎（3个关节，0-3）、腱鞘炎（屈肌腱，0-3）、腱鞘炎（9个部位，0-1）、伸肌腱周围炎症（PETI）（0-3）和皮下组织炎症（SCTI）（0-3）的检测和评分。结果：70例患者[女性44例；平均（SD）年龄51（12.4）岁]，其中64人完成了研究。其中，15人（23.4%）在12个月的随访期间被诊断为PsA。在指水平，基线BM和PD滑膜炎、BM腱鞘炎、BM和PD腱鞘炎、BM和PD PETI的存在和数量与PsA诊断相关（p < 0.05）。包含PD滑膜炎和BM骨髓炎两个变量的预测模型可以预测PsA的诊断(χ2 = 35.38；P < 0.001)，准确度为89.1%，灵敏度为86.7%，特异性为89.8%。结论：超声评估的指炎病变与PsA的诊断以及PsO和手关节痛患者PsA的短期发展相关。

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引用次数: 0

Can we modulate the gut microbiome to enhance DMARD efficacy in rheumatoid arthritis? 我们能否通过调节肠道微生物组来提高类风湿关节炎的 DMARD 疗效？

IF 4.6 2区医学 Q1 RHEUMATOLOGY

Seminars in arthritis and rheumatism

Pub Date : 2025-02-01 DOI: 10.1016/j.semarthrit.2024.152583

Rebecca B. Blank , Renuka R. Nayak , Jose U. Scher

引用次数: 0

Artificial intelligence as an assistant for studying treatment response in rheumatoid arthritis 人工智能是研究类风湿关节炎治疗反应的助手。

IF 4.6 2区医学 Q1 RHEUMATOLOGY

Seminars in arthritis and rheumatism

Pub Date : 2025-02-01 DOI: 10.1016/j.semarthrit.2024.152591

Katherine P. Liao , Tianxi Cai

引用次数: 0

Response letter to the editor 给编辑的回信。

IF 4.6 2区医学 Q1 RHEUMATOLOGY

Seminars in arthritis and rheumatism

Pub Date : 2025-02-01 DOI: 10.1016/j.semarthrit.2024.152597

Don L. Goldenberg

引用次数: 0

Using patient reported outcomes measurement information system (PROMIS®) measures in rheumatoid arthritis clinical care, research, and trials 在类风湿关节炎临床护理、研究和试验中使用患者报告结果测量信息系统 (PROMIS®) 测量。

IF 4.6 2区医学 Q1 RHEUMATOLOGY

Seminars in arthritis and rheumatism

Pub Date : 2025-02-01 DOI: 10.1016/j.semarthrit.2024.152576

Clifton O. Bingham , Susan J. Bartlett

引用次数: 0

Unraveling the role of neutrophil extracellular traps in rheumatoid arthritis: From triggers to therapeutic targets 揭示中性粒细胞胞外捕获物在类风湿关节炎中的作用：从诱因到治疗目标。

IF 4.6 2区医学 Q1 RHEUMATOLOGY

Seminars in arthritis and rheumatism

Pub Date : 2025-02-01 DOI: 10.1016/j.semarthrit.2024.152585

Carmelo Carmona-Rivera, Shuichiro Nakabo, Mariana J. Kaplan

引用次数: 0

Defining immune cell phenotypes that distinguish treatment responders and non-responders in RA 确定区分 RA 治疗应答者和非应答者的免疫细胞表型。

IF 4.6 2区医学 Q1 RHEUMATOLOGY

Seminars in arthritis and rheumatism

Pub Date : 2025-02-01 DOI: 10.1016/j.semarthrit.2024.152581

Kathryne E. Marks , Alice Horisberger , Daniel H. Solomon , Deepak A. Rao

引用次数: 0

Comments on the article by Goldman et al. 对 Goldman 等人文章的评论

IF 4.6 2区医学 Q1 RHEUMATOLOGY

Seminars in arthritis and rheumatism

Pub Date : 2025-02-01 DOI: 10.1016/j.semarthrit.2024.152595

Emre Bilgin , Sedat Kiraz

引用次数: 0

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