Pub Date : 2025-11-13DOI: 10.1016/j.semarthrit.2025.152862
Melissa Oliver , Farzana Nuruzzaman , Aleksander Lenert , Arundathi Jayatilleke , Alexander Theos , Natalia Palmou-Fontana , Alissa Skinner , Marinka Twilt , Eveline Y. Wu , Cassyanne Aguiar , Samir Shah , Micol Romano , Suzanne Li , Sivia Lapidus , Jenna King , Sierra Gerber , Bethany Welc , Lindsey Bergstrom , Emily Fox , Matthew Hollander , Yongdong Zhao
Introduction
Chronic nonbacterial osteomyelitis (CNO) and synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome are autoinflammatory bone diseases of unknown etiology that present with bone pain and varying degrees of extraosseous manifestations such as skin, intestinal and joint involvement. Currently, there are no validated outcome measurement sets that represent the input from all collaborating groups.
Methods
The OMERACT CNO & SAPHO working group performed a scoping review to identify domains previously used in CNO and SAPHO clinical studies. The list of potential domains was narrowed through a process of binning and winnowing.
Results
A scoping review included 260 observational studies published from 1978 -2020 and 220 domains were initially identified. Domains were reduced to 25 through a binning and winnowing process. Domains cover each of the OMERACT core with most domains mapped to life impact and pathophysiological manifestations.
Conclusion
We identified 25 potential domains covering health concepts of function, disease manifestations, pain, and impact on mental health and societal participation to be included in the final core domain set. The next step will be to reach a consensus on the final CNO & SAPHO core domain set and begin instrument selection.
{"title":"Identifying domains for CNO and SAPHO: A scoping review to create domains from existing outcomes by the OMERACT CNO and SAPHO working group","authors":"Melissa Oliver , Farzana Nuruzzaman , Aleksander Lenert , Arundathi Jayatilleke , Alexander Theos , Natalia Palmou-Fontana , Alissa Skinner , Marinka Twilt , Eveline Y. Wu , Cassyanne Aguiar , Samir Shah , Micol Romano , Suzanne Li , Sivia Lapidus , Jenna King , Sierra Gerber , Bethany Welc , Lindsey Bergstrom , Emily Fox , Matthew Hollander , Yongdong Zhao","doi":"10.1016/j.semarthrit.2025.152862","DOIUrl":"10.1016/j.semarthrit.2025.152862","url":null,"abstract":"<div><h3>Introduction</h3><div>Chronic nonbacterial osteomyelitis (CNO) and synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome are autoinflammatory bone diseases of unknown etiology that present with bone pain and varying degrees of extraosseous manifestations such as skin, intestinal and joint involvement. Currently, there are no validated outcome measurement sets that represent the input from all collaborating groups.</div></div><div><h3>Methods</h3><div>The OMERACT CNO & SAPHO working group performed a scoping review to identify domains previously used in CNO and SAPHO clinical studies. The list of potential domains was narrowed through a process of binning and winnowing.</div></div><div><h3>Results</h3><div>A scoping review included 260 observational studies published from 1978 -2020 and 220 domains were initially identified. Domains were reduced to 25 through a binning and winnowing process. Domains cover each of the OMERACT core with most domains mapped to life impact and pathophysiological manifestations.</div></div><div><h3>Conclusion</h3><div>We identified 25 potential domains covering health concepts of function, disease manifestations, pain, and impact on mental health and societal participation to be included in the final core domain set. The next step will be to reach a consensus on the final CNO & SAPHO core domain set and begin instrument selection.</div></div>","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":"75 ","pages":"Article 152862"},"PeriodicalIF":4.4,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145574333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-10DOI: 10.1016/j.semarthrit.2025.152871
Line Kjær Winberg , Mojgan Sarafrazi , Malte Lund Adamsen , Amanda Hempel Zinglersen , Henrik Christian Bidstrup Leffers , Louise Pyndt Diederichsen , Søren Jacobsen
Background
The role of nailfold videocapillaroscopy (NVC) in systemic lupus erythematosus (SLE) remains undefined. Prognostic tools are needed for SLE as the phenotypes differ in prognosis and treatment. Recent studies have reported a high prevalence of capillary abnormalities in SLE. This study investigated whether distinct NVC patterns are associated with distinct SLE phenotypes.
Methods
We did NVC and comprehensive clinical characterisation in 56 patients with SLE. Correlations within NVC findings were tested using Spearman's rho. Subsets of patients with similar NVC changes were identified through hierarchical cluster analysis of principal components based on Z-normalised scores, and associations with clinical phenotypes were analysed using multinomial logistic regression.
Results
The cohort included 56 patients with SLE who had a median SLEDAI score of 6 (interquartile range: 3–10). The capillaroscopic alterations observed were ramifications (66%), disorganisation (89%), tortuous appearance (75%), low density (86%), meandering appearance (52%), dilatations (23%), and microhaemorrhages (29%). Cluster analysis identified three clusters: one dominated by ramifications (n = 16), one dominated by dilations (n = 10), and an unspecific reference cluster. The cluster dominated by ramifications correlated with chronic cutaneous lupus and Raynaud's phenomenon, while the cluster dominated by dilatations correlated with antiphospholipid syndrome and the presence of ≥2 antiphospholipid antibodies.
Conclusions
Capillaroscopic alterations are common in patients with SLE, and capillary ramifications and dilations are linked to distinct SLE phenotypes. The potential of NVC as a prognostic tool for specific organ involvement in patients with SLE should be further explored, hopefully paving the way for early prevention of severe manifestations and damage.
{"title":"Distinct changes in nailfold capillaries are associated with the clinical and serological features of patients with systemic lupus erythematosus","authors":"Line Kjær Winberg , Mojgan Sarafrazi , Malte Lund Adamsen , Amanda Hempel Zinglersen , Henrik Christian Bidstrup Leffers , Louise Pyndt Diederichsen , Søren Jacobsen","doi":"10.1016/j.semarthrit.2025.152871","DOIUrl":"10.1016/j.semarthrit.2025.152871","url":null,"abstract":"<div><h3>Background</h3><div>The role of nailfold videocapillaroscopy (NVC) in systemic lupus erythematosus (SLE) remains undefined. Prognostic tools are needed for SLE as the phenotypes differ in prognosis and treatment. Recent studies have reported a high prevalence of capillary abnormalities in SLE. This study investigated whether distinct NVC patterns are associated with distinct SLE phenotypes.</div></div><div><h3>Methods</h3><div>We did NVC and comprehensive clinical characterisation in 56 patients with SLE. Correlations within NVC findings were tested using Spearman's rho. Subsets of patients with similar NVC changes were identified through hierarchical cluster analysis of principal components based on Z-normalised scores, and associations with clinical phenotypes were analysed using multinomial logistic regression.</div></div><div><h3>Results</h3><div>The cohort included 56 patients with SLE who had a median SLEDAI score of 6 (interquartile range: 3–10). The capillaroscopic alterations observed were ramifications (66%), disorganisation (89%), tortuous appearance (75%), low density (86%), meandering appearance (52%), dilatations (23%), and microhaemorrhages (29%). Cluster analysis identified three clusters: one dominated by ramifications (<em>n</em> = 16), one dominated by dilations (<em>n</em> = 10), and an unspecific reference cluster. The cluster dominated by ramifications correlated with chronic cutaneous lupus and Raynaud's phenomenon, while the cluster dominated by dilatations correlated with antiphospholipid syndrome and the presence of ≥2 antiphospholipid antibodies.</div></div><div><h3>Conclusions</h3><div>Capillaroscopic alterations are common in patients with SLE, and capillary ramifications and dilations are linked to distinct SLE phenotypes. The potential of NVC as a prognostic tool for specific organ involvement in patients with SLE should be further explored, hopefully paving the way for early prevention of severe manifestations and damage.</div></div>","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":"75 ","pages":"Article 152871"},"PeriodicalIF":4.4,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145534612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-10DOI: 10.1016/j.semarthrit.2025.152860
Helena Achten , Deroo Liselotte , Vanhoof Sophie , De Boeck Kristel , Deprez Joke , Dumas Emilie , Genbrugge Eva , Bauters Wouter , Roels Dimitri , Dochy Frederick , Creytens David , Elewaut Dirk , Isabelle Peene
{"title":"Corrigendum to “Autonomic dysfunction symptoms in Sjögren's Disease: A missed dimension linked to disease burden and work disability” [Seminars in Arthritis and Rheumatology 75 (2025) 152832]","authors":"Helena Achten , Deroo Liselotte , Vanhoof Sophie , De Boeck Kristel , Deprez Joke , Dumas Emilie , Genbrugge Eva , Bauters Wouter , Roels Dimitri , Dochy Frederick , Creytens David , Elewaut Dirk , Isabelle Peene","doi":"10.1016/j.semarthrit.2025.152860","DOIUrl":"10.1016/j.semarthrit.2025.152860","url":null,"abstract":"","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":"75 ","pages":"Article 152860"},"PeriodicalIF":4.4,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145496623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Commentary on: “Prevalence of frailty and prefrailty in systemic lupus erythematosus: A systematic review and meta-analysis”","authors":"Digvijay Singh Rajawat , Saketh Sainag Mandiga , Venkata Dileep Kumar Veldi","doi":"10.1016/j.semarthrit.2025.152876","DOIUrl":"10.1016/j.semarthrit.2025.152876","url":null,"abstract":"","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":"75 ","pages":"Article 152876"},"PeriodicalIF":4.4,"publicationDate":"2025-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145575989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-08DOI: 10.1016/j.semarthrit.2025.152867
Yanhao Chen , Xiang Li , Jiao Zhang , Xingyu Yang , Jie Bao , Yongsheng Fan , Shuo Huang
{"title":"Considerations for integrating SGLT2 inhibitors into systemic lupus erythematosus management: Opportunities and challenges","authors":"Yanhao Chen , Xiang Li , Jiao Zhang , Xingyu Yang , Jie Bao , Yongsheng Fan , Shuo Huang","doi":"10.1016/j.semarthrit.2025.152867","DOIUrl":"10.1016/j.semarthrit.2025.152867","url":null,"abstract":"","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":"75 ","pages":"Article 152867"},"PeriodicalIF":4.4,"publicationDate":"2025-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145524341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Estimating the incidence of new thrombotic and hemorrhagic events in a single-center prospective cohort of Primary Antiphospholipid Syndrome (PAPS) patients over approximately 7.5 years and identifying risk factors associated with a first recurrent thrombotic and hemorrhagic event.
Methods
Incidence rates of thrombosis and hemorrhage were calculated considering that patients remained at continuous risk and could experience multiple events. For time-to-event analysis of the first thrombotic episode, patients were followed until their first thrombotic event or last outpatient visit, and baseline clinical and laboratory data were compared. Statistical analysis included Kaplan-Meier curves, log-rank test and Cox proportional hazards modeling.
Results
A total of 155 PAPS patients were included, 83.2 % were female. Hypertension was present in 43.9 %, and diabetes in 9 %. Lupus anticoagulant was the most common antibody (93.4 %). During 942 patient-years of follow-up, 32 thrombotic events (18 arterial, 12 venous, and 2 thrombotic microangiopathies) occurred in 26 patients, yielding an incidence rate of 3.4 per 100 patient-years. The INR was within the therapeutic target in 50 % of the 22 events. The incidence of a first thrombotic event was 3.2 per 100 patient-years, occurring at a mean of 3.2 ± 2.0 years. Diabetes was independently associated with increased thrombotic risk (HR 4.10, 95 % CI 1.72–9.78, p = 0.001). Eight first major hemorrhages were recorded (0.9 per 100 patient-years), with baseline microvascular involvement as associated risk factor (HR 9.04, 95 % CI 2.15–37.92, p = 0.003).
Conclusion
Thrombotic events were frequent in PAPS, even with therapeutic INR. Diabetes increased 4-fold the risk of a first thrombotic event.
目的：估计原发性抗磷脂综合征（PAPS）患者在大约7.5年的单中心前瞻性队列中新的血栓和出血事件的发生率，并确定与首次复发血栓和出血事件相关的危险因素。方法：考虑到患者处于持续的危险状态，可能会发生多种事件，计算血栓和出血的发生率。对于第一次血栓发作的时间-事件分析，患者被跟踪直到他们的第一次血栓事件或最后一次门诊就诊，并比较基线临床和实验室数据。统计分析采用Kaplan-Meier曲线、log-rank检验和Cox比例风险模型。结果：共纳入155例PAPS患者，其中83.2%为女性。高血压占43.9%，糖尿病占9%。狼疮抗凝血是最常见的抗体（93.4%）。在942例患者年的随访中，26例患者发生32例血栓事件（18例动脉，12例静脉，2例血栓性微血管病变），发病率为3.4 / 100例患者年。在22个事件中，50%的INR在治疗目标范围内。首次血栓事件的发生率为3.2 / 100患者年，平均发生时间为3.2±2.0年。糖尿病与血栓形成风险增加独立相关（HR 4.10, 95% CI 1.72-9.78, p = 0.001）。记录了8例首次大出血（每100患者年0.9例），基线微血管受累是相关的危险因素（HR 9.04, 95% CI 2.15-37.92, p = 0.003）。结论：即使治疗性INR，血栓性事件在PAPS患者中也很常见。糖尿病患者发生首次血栓事件的风险增加了4倍。
{"title":"Recurrent thrombosis and hemorrhagic events in a large single-center primary antiphospholipid syndrome cohort: Results from APS-Rio cohort after nearly 1,000 patient-years of follow-up","authors":"Flavio Signorelli , Gustavo Guimarães Moreira Balbi , Vinícius Pereira Bastos , Thaiana Reis-Carvalho , Evandro Mendes Klumb , Roger Abramino Levy","doi":"10.1016/j.semarthrit.2025.152873","DOIUrl":"10.1016/j.semarthrit.2025.152873","url":null,"abstract":"<div><h3>Objective</h3><div>Estimating the incidence of new thrombotic and hemorrhagic events in a single-center prospective cohort of Primary Antiphospholipid Syndrome (PAPS) patients over approximately 7.5 years and identifying risk factors associated with a first recurrent thrombotic and hemorrhagic event.</div></div><div><h3>Methods</h3><div>Incidence rates of thrombosis and hemorrhage were calculated considering that patients remained at continuous risk and could experience multiple events. For time-to-event analysis of the first thrombotic episode, patients were followed until their first thrombotic event or last outpatient visit, and baseline clinical and laboratory data were compared. Statistical analysis included Kaplan-Meier curves, log-rank test and Cox proportional hazards modeling.</div></div><div><h3>Results</h3><div>A total of 155 PAPS patients were included, 83.2 % were female. Hypertension was present in 43.9 %, and diabetes in 9 %. Lupus anticoagulant was the most common antibody (93.4 %). During 942 patient-years of follow-up, 32 thrombotic events (18 arterial, 12 venous, and 2 thrombotic microangiopathies) occurred in 26 patients, yielding an incidence rate of 3.4 per 100 patient-years. The INR was within the therapeutic target in 50 % of the 22 events. The incidence of a first thrombotic event was 3.2 per 100 patient-years, occurring at a mean of 3.2 ± 2.0 years. Diabetes was independently associated with increased thrombotic risk (HR 4.10, 95 % CI 1.72–9.78, <em>p</em> = 0.001). Eight first major hemorrhages were recorded (0.9 per 100 patient-years), with baseline microvascular involvement as associated risk factor (HR 9.04, 95 % CI 2.15–37.92, <em>p</em> = 0.003).</div></div><div><h3>Conclusion</h3><div>Thrombotic events were frequent in PAPS, even with therapeutic INR. Diabetes increased 4-fold the risk of a first thrombotic event.</div></div>","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":"75 ","pages":"Article 152873"},"PeriodicalIF":4.4,"publicationDate":"2025-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145557945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-08DOI: 10.1016/j.semarthrit.2025.152877
Gul Guzelant Ozkose, Berna Yurttas, Sinem Nihal Esatoglu, Muhlis Cem Ar, Vedat Hamuryudan, Gulen Hatemi
{"title":"Response to Commentary on “Factors associated with thrombosis in Behçet Syndrome: A systematic review and meta-analysis”","authors":"Gul Guzelant Ozkose, Berna Yurttas, Sinem Nihal Esatoglu, Muhlis Cem Ar, Vedat Hamuryudan, Gulen Hatemi","doi":"10.1016/j.semarthrit.2025.152877","DOIUrl":"10.1016/j.semarthrit.2025.152877","url":null,"abstract":"","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":"75 ","pages":"Article 152877"},"PeriodicalIF":4.4,"publicationDate":"2025-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145525276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-08DOI: 10.1016/j.semarthrit.2025.152863
Aurore Abel , Rachel Robert , Arthur Felix , Illitch Coco-Viloin , Florence Moinet , Remi Bellance , Emmanuelle Amazan , Moustapha Agossou , Emma Pierrisnard , Fabienne Louis-Sidney , Christophe Deligny , Benoit Suzon
Objective
To describe the epidemiology, characteristics and evolution of African descent patients with IIM in the Caribbean Island of Martinique with free access to high standard socialized healthcare.
Methods
Retrospective longitudinal study from January 1, 2000 to June 2023 at the University Hospital of Martinique, the island’s only tertiary care center. Patients with clinically myopathic or amyopathic adult-onset dermatomyositis (DM), polymyositis (PM), anti-synthetase syndrome (ASyS), immune-mediated necrotizing myositis (IMNM), overlap myositis (OM) were included. Baseline clinical, immunological, radiological characteristics, and treatments were collected along with occurrence of relapses and deaths
Results
Mean IIM incidence was 2.34/100,000. The 2022 prevalence of IIM reached 32.2/100,000 inhabitants, with variations between subtypes. 174 patients were included, of whom 55 (32 %) had ASyS, 44 (25 %) OM, 44 (25 %) DM, 16 (9 %) PM, 14 (8 %) IMNM and 1 (0.6 %) IBM. Median time from first symptoms to diagnosis was 4.2 months [2.0 to 12.3]. Anti-Jo1, anti-PL12 and anti-SRP were the most frequent myositis specific autoantibody detected. Most frequent manifestations were arthralgia (65 %), muscle weakness (61 %) and skin DM lesions (53 %). At diagnosis, 77 (52 %) and 28 patients (16 %) had interstitial lung disease (ILD) and cardiac involvement, respectively. ASyS was more frequently clinically amyopathic (p < 0.05) and had more frequently ILD (p < 0.05). After treatments, sixty-nine patients (40 %) relapsed in a median time of 2.8 years [1.1 to 7.2].
Conclusion
There is a high incidence and prevalence of IIM in the Caribbean Island of Martinique, and a pulmonary and cardiac threat at IIM diagnosis in African descent population.
{"title":"Overall and by subtype epidemiology of idiopathic inflammatory myopathies among African descent patients with free access to high standard healthcare","authors":"Aurore Abel , Rachel Robert , Arthur Felix , Illitch Coco-Viloin , Florence Moinet , Remi Bellance , Emmanuelle Amazan , Moustapha Agossou , Emma Pierrisnard , Fabienne Louis-Sidney , Christophe Deligny , Benoit Suzon","doi":"10.1016/j.semarthrit.2025.152863","DOIUrl":"10.1016/j.semarthrit.2025.152863","url":null,"abstract":"<div><h3>Objective</h3><div>To describe the epidemiology, characteristics and evolution of African descent patients with IIM in the Caribbean Island of Martinique with free access to high standard socialized healthcare.</div></div><div><h3>Methods</h3><div>Retrospective longitudinal study from January 1, 2000 to June 2023 at the University Hospital of Martinique, the island’s only tertiary care center. Patients with clinically myopathic or amyopathic adult-onset dermatomyositis (DM), polymyositis (PM), anti-synthetase syndrome (ASyS), immune-mediated necrotizing myositis (IMNM), overlap myositis (OM) were included. Baseline clinical, immunological, radiological characteristics, and treatments were collected along with occurrence of relapses and deaths</div></div><div><h3>Results</h3><div>Mean IIM incidence was 2.34/100,000. The 2022 prevalence of IIM reached 32.2/100,000 inhabitants, with variations between subtypes. 174 patients were included, of whom 55 (32 %) had ASyS, 44 (25 %) OM, 44 (25 %) DM, 16 (9 %) PM, 14 (8 %) IMNM and 1 (0.6 %) IBM. Median time from first symptoms to diagnosis was 4.2 months [2.0 to 12.3]. Anti-Jo1, anti-PL12 and anti-SRP were the most frequent myositis specific autoantibody detected. Most frequent manifestations were arthralgia (65 %), muscle weakness (61 %) and skin DM lesions (53 %). At diagnosis, 77 (52 %) and 28 patients (16 %) had interstitial lung disease (ILD) and cardiac involvement, respectively. ASyS was more frequently clinically amyopathic (<em>p</em> < 0.05) and had more frequently ILD (<em>p</em> < 0.05). After treatments, sixty-nine patients (40 %) relapsed in a median time of 2.8 years [1.1 to 7.2].</div></div><div><h3>Conclusion</h3><div>There is a high incidence and prevalence of IIM in the Caribbean Island of Martinique, and a pulmonary and cardiac threat at IIM diagnosis in African descent population.</div></div>","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":"75 ","pages":"Article 152863"},"PeriodicalIF":4.4,"publicationDate":"2025-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-07DOI: 10.1016/j.semarthrit.2025.152866
Sarah N. Pimple , Alanna M. Chamberlain , Sara J. Achenbach , Cynthia S. Crowson , Elena Myasoedova
Objectives
Assess atrial fibrillation (AF) risk in patients with rheumatoid arthritis (RA) versus general population and identify predictors of AF in RA.
Methods
Retrospective medical records review was completed to form an inception cohort of all patients with RA (1990–2019), among residents of 8 southern MN counties, aged ≥18 years. Each patient with RA was matched on age, sex, year, and county to randomly selected non-RA comparator and followed until incident AF, death, migration, or 12/31/2023. AF was defined using an electronic algorithm.
Results
1899 patients with RA and 1899 non-RA comparators (mean age 55.9 years, 68.5% female) were included. Occurrence of AF was similar in RA vs. non-RA, adjusting for age, sex, year, smoking, and obesity: HR:1.10; 95%CI:0.92–1.33. The 10-year cumulative incidence of AF was 9.5% in RA versus 8.8% in non-RA. In RA, significant risk factors for incident AF included age (HR:2.29 per 10-year increase; 95%CI:2.05–2.56), male sex (HR:1.57; 95%CI:1.22–2.03), former smoking (HR:1.35; 95%CI:1.01–1.81), current smoking (HR:2.16; 95%CI:1.51–3.09), obesity (HR:1.83, 95%CI:1.42–2.37), diabetes (HR:1.54, 95%CI:1.09–2.17), hypertension (HR:1.60; 95%CI:1.20–2.13), rheumatoid nodules (HR:1.77; 95%CI:1.23–2.55), large joint swelling (HR:1.32; 95%CI:1.01–1.73), and severe extra-articular manifestations (HR:1.88; 95%CI:1.17–3.02). AF occurrence rate was higher among patients with severe RA (i.e., erosions/destructive changes, nodules, or severe extra-articular manifestations in the first year) compared to non-RA (HR:1.46; 95%CI:1.09–1.94).
Conclusion
Adverse cardiovascular risk profile and RA disease severity significantly increased the risk of AF among patients with RA. Future studies will inform to what extent early recognition and management of these factors improves AF outcomes in RA.
{"title":"Risk factors for incident atrial fibrillation in rheumatoid arthritis patients: A population based cohort study","authors":"Sarah N. Pimple , Alanna M. Chamberlain , Sara J. Achenbach , Cynthia S. Crowson , Elena Myasoedova","doi":"10.1016/j.semarthrit.2025.152866","DOIUrl":"10.1016/j.semarthrit.2025.152866","url":null,"abstract":"<div><h3>Objectives</h3><div>Assess atrial fibrillation (AF) risk in patients with rheumatoid arthritis (RA) versus general population and identify predictors of AF in RA.</div></div><div><h3>Methods</h3><div>Retrospective medical records review was completed to form an inception cohort of all patients with RA (1990–2019), among residents of 8 southern MN counties, aged ≥18 years. Each patient with RA was matched on age, sex, year, and county to randomly selected non-RA comparator and followed until incident AF, death, migration, or 12/31/2023. AF was defined using an electronic algorithm.</div></div><div><h3>Results</h3><div>1899 patients with RA and 1899 non-RA comparators (mean age 55.9 years, 68.5% female) were included. Occurrence of AF was similar in RA vs. non-RA, adjusting for age, sex, year, smoking, and obesity: HR:1.10; 95%CI:0.92–1.33. The 10-year cumulative incidence of AF was 9.5% in RA versus 8.8% in non-RA. In RA, significant risk factors for incident AF included age (HR:2.29 per 10-year increase; 95%CI:2.05–2.56), male sex (HR:1.57; 95%CI:1.22–2.03), former smoking (HR:1.35; 95%CI:1.01–1.81), current smoking (HR:2.16; 95%CI:1.51–3.09), obesity (HR:1.83, 95%CI:1.42–2.37), diabetes (HR:1.54, 95%CI:1.09–2.17), hypertension (HR:1.60; 95%CI:1.20–2.13), rheumatoid nodules (HR:1.77; 95%CI:1.23–2.55), large joint swelling (HR:1.32; 95%CI:1.01–1.73), and severe extra-articular manifestations (HR:1.88; 95%CI:1.17–3.02). AF occurrence rate was higher among patients with severe RA (i.e., erosions/destructive changes, nodules, or severe extra-articular manifestations in the first year) compared to non-RA (HR:1.46; 95%CI:1.09–1.94).</div></div><div><h3>Conclusion</h3><div>Adverse cardiovascular risk profile and RA disease severity significantly increased the risk of AF among patients with RA. Future studies will inform to what extent early recognition and management of these factors improves AF outcomes in RA.</div></div>","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":"75 ","pages":"Article 152866"},"PeriodicalIF":4.4,"publicationDate":"2025-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145513772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-07DOI: 10.1016/j.semarthrit.2025.152878
Anthony V Perruccio , J Denise Power , Mayilee Canizares , Jessica M Wilfong , Elizabeth M Badley
{"title":"Reply to Letter regarding “The role of sex and systemic inflammation in the development of cardiovascular disease in osteoarthritis: A population-based cohort study using the CLSA”","authors":"Anthony V Perruccio , J Denise Power , Mayilee Canizares , Jessica M Wilfong , Elizabeth M Badley","doi":"10.1016/j.semarthrit.2025.152878","DOIUrl":"10.1016/j.semarthrit.2025.152878","url":null,"abstract":"","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":"75 ","pages":"Article 152878"},"PeriodicalIF":4.4,"publicationDate":"2025-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145513846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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