Seminars in arthritis and rheumatism最新文献

{"title":"Interplay between polygenic risk score and solar insolation: Implication for systemic lupus erythematosus diagnosis and pathogenesis","authors":"I-Chieh Chen ,&nbsp;Ta-Chien Chan ,&nbsp;Hui-Wen Yang ,&nbsp;Yen-Ju Chen ,&nbsp;Yi-Ming Chen","doi":"10.1016/j.semarthrit.2024.152531","DOIUrl":"10.1016/j.semarthrit.2024.152531","url":null,"abstract":"<div><h3>Objectives</h3><p>This research elucidates the correlation between solar radiation insolation, polygenic risk score (PRS), and systemic lupus erythematosus (SLE) diagnosis, utilizing genomic, environmental, and clinical data.</p></div><div><h3>Methods</h3><p>We included 1,800 SLE participants and 1,800 controls from the Taiwan Precision Medicine Initiative, genotyped via the Affymetrix Genome-Wide TWB 2.0 SNP Array. The study employed a SLE-PRS tailored for individuals of Taiwanese ancestry, comprising 27 single nucleotide polymorphisms (SNPs). QGIS computed solar radiation insolation from participants' residences. We employed logistic regression to investigate the associations between SLE-PRS, solar insolation susceptibility, and SLE. Additive and multiplicative interactions were utilized to assess the interactions between solar insolation and SLE-PRS regarding the risk of SLE.</p></div><div><h3>Results</h3><p>SLE patients showed decreased solar insolation (<em>p</em> &lt; 0.001). The highest decile of SLE-PRS exhibited a statistically significant lower solar insolation 1, 3, 6, and 12 months prior to diagnosis as compared to the lowest decile. Specifically, there were significant differences observed at 1 and 12 months (<em>p</em> = 0.025 and <em>p</em> = 0.004, respectively). It suggests that higher SLE-PRS correlated with reduced solar insolation tolerance. We observed an increase in SLE risk across ascending SLE-PRS percentiles exclusively in the high solar insolation group, not in the low solar insolation group. However, the interaction effect of SLE-PRS and solar insolation on SLE risk is not statistically significant. Compared to the lowest decile, the highest SLE-PRS decile showed a 10.98-fold increase in SLE risk (95 % CI, 3.773–31.952, <em>p</em> &lt; 0.001). High SLE-PRS scores in conjunction with high solar insolation contribute to SLE incidence.</p></div><div><h3>Conclusions</h3><p>Our study unveils the intertwined nature of UV insolation and polygenic risks in SLE. Future studies should explore the preventative potential of robust solar radiation protection for high-risk individuals before the disease onset.</p></div>","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141998547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical stratification of 1318 Primary Sjögren's Syndrome patients","authors":"Jinxia Fang ,&nbsp;Jiajia Wang ,&nbsp;Jing Luo ,&nbsp;Ping Wang ,&nbsp;Jin Zhang ,&nbsp;Dan Chen ,&nbsp;Wenjing Ye ,&nbsp;Yi Zhang ,&nbsp;Shaobiao Pan ,&nbsp;Xiaobing Wang","doi":"10.1016/j.semarthrit.2024.152537","DOIUrl":"10.1016/j.semarthrit.2024.152537","url":null,"abstract":"<div><h3>Objective</h3><p>Primary Sjögren's Syndrome (pSS) is a complex autoimmune disorder characterized by diverse clinical manifestations yet lacking effective therapeutic strategies currently. This study aims to gain a thorough understanding of the clinical landscape of pSS and further delineate its clinical subtypes, thereby enabling the efficient management for pSS.</p></div><div><h3>Methods</h3><p>We conducted a cross-sectional observational study of 1318 pSS patients. The pSS patients were categorized and compared based on gender, anti-SSA antibodies, and labial salivary gland biopsies (LGSB). Unsupervised clustering analysis was employed to identify pSS subtypes using systemic involvement among patients. Furthermore, we assessed clinical and biological variances among these subtypes.</p></div><div><h3>Results</h3><p>Through group comparisons, we observed more pronounced extraglandular manifestations among male patients, SSA-negative group, and those with positive LGSB results. Based on systemic involvement, pSS patients were categorized into four groups. C1 exhibited minimal systemic involvement, lacking hematologic or serologic manifestations, with the lowest ESSDAI scores. C2 presented with serologic changes in all patients, partial joint involvement, and no hematologic systemic manifestations. C3 lacked joint involvement but all members displayed hematologic systemic involvement, with higher rates of renal, cutaneous, and systemic manifestations. C4 encompassed patients with joint and hematologic involvement, displaying the highest ESSDAI scores. The positivity rates of antibodies, immunological parameters, and inflammatory markers exhibited significant differences among the groups. Furthermore, notable variances were observed in the expression of peripheral blood transcriptomic modules among these groups.</p></div><div><h3>Conclusion</h3><p>In this cohort study, we summarized the clinical characteristics of Chinese patients with pSS and identified four distinct subgroups of pSS based on systemic involvement, revealing clinical and molecular disparities that unveil distinct pathobiological endotypes. Our findings hold significant implications for clinical management.</p></div>","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141985636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of idiopathic inflammatory myopathies patients with anti-PM/Scl antibodies","authors":"Longyang Zhu ,&nbsp;Chen Zong ,&nbsp;Yiran Chen ,&nbsp;Guochun Wang ,&nbsp;Yongpeng Ge","doi":"10.1016/j.semarthrit.2024.152536","DOIUrl":"10.1016/j.semarthrit.2024.152536","url":null,"abstract":"<div><h3>Objectives</h3><p>To analyze the clinical features of idiopathic inflammatory myopathies (IIMs) patients with anti-PM/Scl antibodies.</p></div><div><h3>Methods</h3><p>In this retrospective cohort study, we compared the clinical manifestations between patients who were solely positive for anti-PM/Scl antibodies (isolated anti-PM/Scl group) and those with a coexistence of anti-PM/Scl antibodies and myositis-specific antibodies (MSAs) (double-positive group).</p></div><div><h3>Results</h3><p>Sixty-five IIMs patients positive for anti-PM/Scl antibodies were included, among whom 51 (78.5 %) were females, with a mean age of 49.1 years. Thirty-four (52.3 %) patients coexisted with MSAs. Compared to the double-positive group, the isolated anti-PM/Scl group demonstrated a higher proportion of women (90.3 % vs 67.6 %, <em>p</em> = 0.026) and a higher incidence of sclerodactyly (16.1 % vs 0, <em>p</em> = 0.021). Although there were no differences in the incidence of muscular weakness, dysphagia, or creatine kinase levels, thigh magnetic resonance imaging (MRI) revealed less muscle edema, atrophy, and fatty replacement in the isolated anti-PM/Scl group (<em>p</em> &lt; 0.05). Interstitial lung disease (ILD) occurred in 80 % of patients, more frequently in the double-positive group (90.6 % vs 67.9 %, <em>p</em> = 0.028). According to HRCT, non-specific interstitial pneumonia (NSIP) was the most common pattern among anti-PM/Scl antibodies positive IIMs patients. The double-positive group exhibited higher ferritin levels, and a lower peripheral lymphocyte count (<em>p</em> &lt; 0.05). The mortality rate in the double-positive group was higher than that in the isolated anti-PM/Scl group (20.6 % vs 0, <em>p</em> = 0.034).</p></div><div><h3>Conclusion</h3><p>Among IIMs patients who tested positive for anti-PM/Scl antibodies, ILD emerged as the predominant clinical feature, particularly when combined with MSA. Notably, patients with isolated anti-PM/Scl antibodies exhibited a favorable prognosis following immunotherapy.</p></div>","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0049017224001768/pdfft?md5=c2c57c33f28ded5ead1d6877826f47dc&pid=1-s2.0-S0049017224001768-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone and entheseal targets for growth factors in diffuse idiopathic skeletal hyperostosis","authors":"Geoffrey Owen Littlejohn","doi":"10.1016/j.semarthrit.2024.152532","DOIUrl":"10.1016/j.semarthrit.2024.152532","url":null,"abstract":"<div><h3>Introduction</h3><p>Diffuse idiopathic skeletal hyperostosis (DISH) is a common condition of the adult skeleton where new bone growth occurs in entheseal and bony regions. The cause for the new bone growth is unclear but many lines of evidence point to a role for growth factors linked to abnormal metabolism in these patients. The bone targets for these presumed growth factors are poorly defined. This review summarises the clinical evidence relevant to the sites of origin of new bone formation in DISH to better define potential cellular targets for bone growth in DISH.</p></div><div><h3>Methods</h3><p>This is a narrative review of relevant papers identified from searches of PubMed and online journals.</p></div><div><h3>Results</h3><p>Sites of new bone growth in the enthesis were identified in patients with DISH, with likely cellular targets for growth factors being mesenchymal stem cells in the outer part of the enthesis. Similar undifferentiated skeletal stem cells are present in the outer annulus fibrosis and in the bony eminences of vertebral bodies and other bones, with the potential for response to growth factors.</p></div><div><h3>Conclusion</h3><p>Mesenchymal stem cells are present in specific entheseal and bony locations that are likely responsive to putative growth factors leading to new bone formation characteristic of DISH. Further study of these regions in the context of metabolic abnormalities in DISH will allow for better understanding of the pathophysiology of this common condition.</p></div>","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0049017224001720/pdfft?md5=3aa4eb3edb994d300d40191174489171&pid=1-s2.0-S0049017224001720-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141985665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient questionnaires for clinical decisions at the point of care, in addition to research reports, an intellectual and ethical opportunity for rheumatologists: A tribute to Frederick Wolfe, MD (July 1, 1936 - September 5, 2023).","authors":"Theodore Pincus, Leigh F Callahan","doi":"10.1016/j.semarthrit.2024.152528","DOIUrl":"https://doi.org/10.1016/j.semarthrit.2024.152528","url":null,"abstract":"","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construct validity of PROMIS pain interference, fatigue, and physical function as patient-reported outcomes in adults with idiopathic inflammatory myopathies: An international study from the OMERACT myositis working group","authors":"Ellen Romich ,&nbsp;Didem Saygin ,&nbsp;Dana DiRenzo ,&nbsp;Christopher A. Mecoli ,&nbsp;Ingrid de Groot ,&nbsp;Karin Lodin ,&nbsp;Malin Regardt ,&nbsp;Catherine Sarver ,&nbsp;Ju Yeon Kim ,&nbsp;Jin Kyun Park ,&nbsp;Kelly Beer ,&nbsp;Merrilee Needham ,&nbsp;Helene Alexanderson ,&nbsp;Lisa Christopher-Stine ,&nbsp;Marianne de Visser ,&nbsp;Joost Raaphorst ,&nbsp;OMERACT Myositis Working Group","doi":"10.1016/j.semarthrit.2024.152534","DOIUrl":"10.1016/j.semarthrit.2024.152534","url":null,"abstract":"<div><h3>Background</h3><p>Validated patient-reported outcome measures to assess disease impact in patients with adult idiopathic inflammatory myopathies (IIMs) are needed. The objective of this study was to assess the construct validity of PROMIS Pain Interference, Fatigue, and Physical Function measures in comparison with core disease activity measures.</p></div><div><h3>Methods</h3><p>Adults with IIM, excluding inclusion body myositis, from OMERACT Myositis Working Group (MWG) clinic sites completed PROMIS Short Form v1.0—Pain Interference 6a, PROMIS Short Form v1.0—Fatigue 7a, and PROMIS Short Form v2.0—Physical Function 8b measures. Core disease activity measures including patient and physician global disease activity assessments, manual muscle testing, serum creatine kinase activity, and Health Assessment Questionnaire Disability Index (HAQ-DI) were simultaneously assessed. To evaluate construct validity, a priori hypotheses for the expected correlations between PROMIS measures, age, and core disease measures were determined by &gt;70 % agreement among MWG members and were compared against observed Pearson's correlations. Internal consistency of items and floor or ceiling effects for the PROMIS measures were also assessed. Subgroup analysis according to IIM subtype (dermatomyositis vs. non-dermatomyositis IIM) was performed.</p></div><div><h3>Results</h3><p>135 adults with IIM from 5 countries across North America, Europe, Asia, and Australia were included. For construct validity, a priori hypotheses were confirmed for 5 of 6 (83 %) PROMIS Pain Interference, 4 of 5 (80 %) PROMIS Fatigue, and 3 of 4 (75 %) PROMIS Physical Function correlations. Internal consistency was high for each PROMIS measure (Cronbach's alpha &gt;0.9). Ceiling effects were observed only for PROMIS Pain Interference, with low/no pain in 29 % of patients. Subgroup analysis between dermatomyositis (<em>n</em> = 65) and non-dermatomyositis (<em>n</em> = 70) subtypes demonstrated similar correlations between PROMIS measures and disease activity measures.</p></div><div><h3>Conclusions</h3><p>PROMIS Short Form v1.0—Pain Interference 6a, PROMIS Short Form v1.0—Fatigue 7a, and PROMIS Short Form v2.0—Physical Function 8b measures demonstrate strong construct validity when compared to core disease activity measures in IIM, with consistent results across IIM subtypes. These findings support the use of these selected PROMIS measures to assess core domains of interest for measuring life impact in IIMs.</p></div>","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autoantibodies and damage in patients with idiopathic inflammatory myopathies: A longitudinal multicenter study from the MYONET international network","authors":"Fabricio Espinosa-Ortega ,&nbsp;Karin Lodin ,&nbsp;Maryam Dastmalchi ,&nbsp;Jiri Vencovsky ,&nbsp;Louise P Diederichsen ,&nbsp;Samuel Katsuyuki Shinjo ,&nbsp;Maria Giovanna Danieli ,&nbsp;Albert Selva-O'Callaghan ,&nbsp;Marianne de Visser ,&nbsp;Zoltan Griger ,&nbsp;Angela Ceribelli ,&nbsp;Diana Gómez-Martin ,&nbsp;Helena Andersson ,&nbsp;Mónica Vázquez-Del Mercado ,&nbsp;Hector Chinoy ,&nbsp;James B Lilleker ,&nbsp;Paul New ,&nbsp;Niels S Krogh ,&nbsp;Ingrid E Lundberg ,&nbsp;Helene Alexanderson","doi":"10.1016/j.semarthrit.2024.152529","DOIUrl":"10.1016/j.semarthrit.2024.152529","url":null,"abstract":"<div><h3>Objective</h3><p>To study the trajectories of changes in damage over time and explore associations with autoantibody defined subgroups using a large international cohort of patients with idiopathic inflammatory myopathies (IIM).</p></div><div><h3>Methods</h3><p>Data from the MYONET registry, including patients who were tested for autoantibodies and had at least one assessment of damage using the Myositis Damage Index (MDI), were analyzed. Patients were sub-grouped according to their autoantibody profiles (myositis-specific, myositis-associated, or seronegative). The index date was defined as the time point for the first registered MDI assessment. The longitudinal trajectories of damage with autoantibody status as the main predictor were analyzed using linear mixed models.</p></div><div><h3>Results</h3><p>A total of 757 adult patients were included in this study. Each year of disease duration since diagnosis had an estimated MDI score increase of 0.16 units for the seronegative group (reference). Compared with the seronegative group as reference, patients with dermatomyositis-specific autoantibodies developed less damage per year of follow-up since diagnosis (average 0.08 less score, <em>P</em> = 0.04), whereas patients with anti-PM/Scl autoantibodies developed more damage per year of follow-up since diagnosis (average 0.28 higher score, <em>P</em> = 0.03) independent of sex and age at diagnosis. The seronegative subgroup and the immune-mediated necrotizing myopathy autoantibody subgroup had the strongest correlation between severity of muscle damage and HAQ-DI scores at five years of follow-up, rho=0.84, <em>P</em> &lt; 0.001 and rho=0.72, <em>P</em> &lt; 0.001, respectively.</p></div><div><h3>Conclusion</h3><p>Our study is the first to describe patterns and trajectories of change in damage over time in relation to autoantibody defined subgroups in a large international multicenter cohort of patients with IIM. Patients with anti-PM/Scl scored a greater extent of damage, whereas patients with dermatomyositis-specific antibodies had less damage than seronegative patients. Severity in muscle damage had moderate to strong correlation with functional disability among the IMNM and seronegative subgroups with lower correlations for the other subgroups. These findings suggest that autoantibodies may be useful predictors of long-term damage.</p></div>","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0049017224001690/pdfft?md5=476ba9d478051867d3e6bc859b44b852&pid=1-s2.0-S0049017224001690-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in the autoantibody phenotypes and long-term outcomes between juvenile- and adult-idiopathic inflammatory myopathies","authors":"Hideaki Tsuji ,&nbsp;Ran Nakashima ,&nbsp;Takahiro Yasumi ,&nbsp;Tsuneo Sasai ,&nbsp;Yuki Ichimura ,&nbsp;Mirei Shirakashi ,&nbsp;Hideo Onizawa ,&nbsp;Ryosuke Hiwa ,&nbsp;Koji Kitagori ,&nbsp;Shuji Akizuki ,&nbsp;Akira Onishi ,&nbsp;Hajime Yoshifuji ,&nbsp;Masao Tanaka ,&nbsp;Naoko Okiyama ,&nbsp;Tsuneyo Mimori ,&nbsp;Akio Morinobu","doi":"10.1016/j.semarthrit.2024.152530","DOIUrl":"10.1016/j.semarthrit.2024.152530","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate differences in autoantibodies, clinical features, and long-term outcomes between juvenile-idiopathic inflammatory myopathy (IIM) and adult-IIM</p></div><div><h3>Methods</h3><p>Autoantibodies, clinical characteristics, and drug-free conditions for a maximum of 20 years were retrospectively analyzed in 320 Japanese IIM patients (juvenile-IIM, <em>n</em> = 34; adult-IIM, <em>n</em> = 286) using the Kyoto University Registry.</p></div><div><h3>Results</h3><p>Autoantibodies observed in juvenile-IIM were anti-TIF1-γ (15 %), anti-MDA-5 (15 %), anti-ARS (9 %), and anti-NXP-2 (6 %). Those observed in adult-IIM were anti-ARS (32 %), anti-MDA-5 (23 %), anti-TIF1-γ (8 %), anti-SRP (8 %), anti-Mi-2 (2 %), and anti-NXP-2 (1 %). The cumulative drug-free condition rate was higher in juvenile-IIM than in adult-IIM up to 20 years (juvenile-IIM vs. adult-IIM, 34 % vs. 18 %, <em>p</em> = 0.0016). Anti-TIF1-γ was associated with lesser muscle symptoms (60 % vs. 90 %), malignancy (0 % vs. 57 %), and glucocorticoid use (40 % vs. 86 %) in juvenile-IIM compared to adult-IIM, while juvenile-IIM more achieved drug-free conditions (60 % vs. 25 %). Both juvenile-IIM and adult-IIM with anti-MDA-5 demonstrated a high frequency of amyopathic dermatomyositis, interstitial lung disease (ILD), and multi-immunosuppressive therapy, with high drug-free conditions (50 % vs. 49 %). Both juvenile-IIM and adult-IIM with anti-ARS showed frequent skin rashes, muscle symptoms, and ILD, frequent need for multi-immunosuppressive therapy, and low drug-free condition rates (0 % vs. 3 %). Both juvenile-IIM and adult-IIM with anti-NXP-2 showed frequent skin rashes and muscle symptoms, low ILD frequency, and frequent use of methotrexate and glucocorticoids, which did not achieve drug-free conditions (0 % vs. 0 %).</p></div><div><h3>Conclusions</h3><p>Drug-free condition was achieved more frequently in juvenile-IIM patients than adult-IIM patients. Specific autoantibodies were associated with different clinical characteristics and outcomes between juvenile-IIM and adult-IIM.</p></div>","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141978861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large-vessel imaging in patients with giant cell arteritis with scalp involvement: A commentary on giant cell arteritis associated with scalp, tongue or lip necrosis in a French multi-center case control study","authors":"Daniel Montes ,&nbsp;Nicholas E. Bohrer ,&nbsp;Kenneth J. Warrington ,&nbsp;Matthew J. Koster","doi":"10.1016/j.semarthrit.2024.152512","DOIUrl":"10.1016/j.semarthrit.2024.152512","url":null,"abstract":"","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142012020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally invasive interventional procedures for osteoarthritis and inflammatory arthritis: A systematic review and meta-analysis","authors":"Jacopo Ciaffi ,&nbsp;Nicolas Papalexis ,&nbsp;Elena Vanni ,&nbsp;Marco Miceli ,&nbsp;Cesare Faldini ,&nbsp;Lorenza Scotti ,&nbsp;Antonella Zambon ,&nbsp;Carlo Salvarani ,&nbsp;Roberto Caporali ,&nbsp;Giancarlo Facchini ,&nbsp;Francesco Ursini","doi":"10.1016/j.semarthrit.2024.152525","DOIUrl":"10.1016/j.semarthrit.2024.152525","url":null,"abstract":"<div><h3>Objective</h3><p>to summarize the evidence on the efficacy of minimally invasive interventional procedures such as radiofrequency ablation (RFA) and transcatheter arterial embolization (TAE) in patients with osteoarthritis or inflammatory arthritis.</p></div><div><h3>Methods</h3><p>a literature search was conducted in PubMed and Web of Science databases. Both randomized controlled trials (RCTs) and non-randomized studies of interventions (NRSI) were included. The results were organized according to the treated anatomical site: knee, hip, foot and ankle, shoulder, hand and wrist, sacroiliac joints. Data about treatment efficacy were extracted. The main outcome was change in pain intensity using the 0–10 visual analog scale (VAS) from baseline to 1 month. Additional timepoints at 3, 6 and 12 months were assessed. Change in functional status was evaluated. Pooled estimates were calculated as the mean difference (MD) and 95 % confidence interval relative to baseline. The meta-analyses of RCTs and NRSI were conducted separately.</p></div><div><h3>Results</h3><p>of the 4599 retrieved articles, 164 were included in the review and, considering all the established timepoints, 111 (38 RCTs and 73 NRSI) were selected for the meta-analysis. Only one article described patients with inflammatory arthritis. In the meta-analysis of RCTs, one month after the procedure, MD in VAS was -3.98 (-4.41 to -3.55; <em>k</em> = 21) for knee RFA, and -3.18 (-3.96 to -2.39; <em>k</em> = 8) for sacroiliac joints RFA. In the meta-analysis of NRSI, MD in VAS was -4.12 (-4.63 to -3.61; <em>k</em> = 23) for knee RFA, -3.84 (-4.77 to -2.92; <em>k</em> = 7) for knee TAE, -4.34 (-4.96 to -3.71; <em>k</em> = 2) for hip RFA, -3.83 (-4.52 to -3.15; <em>k</em> = 3) for shoulder RFA and -4.93 (-5.58 to -4.28; <em>k</em> = 14) for sacroiliac joints RFA. Significant decrease in pain intensity was found also at 3, 6 and 12 months. Additionally, functional status improved at all the assessed timepoints.</p></div><div><h3>Conclusion</h3><p>minimally invasive interventional procedures can improve pain and functional status of patients affected by OA or chronic sacroiliac pain of degenerative origin. Further research is warranted in the field of inflammatory rheumatic diseases.</p></div>","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0049017224001653/pdfft?md5=48df68f3ff4538080053d0e62d95877a&pid=1-s2.0-S0049017224001653-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141976547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}