Seminars in cell & developmental biology最新文献

英文中文

Cilia and flagella – Current understanding and recent advances in divergent experimental systems 纤毛和鞭毛——目前对不同实验系统的理解和最新进展

IF 6.2 2区生物学 Q1 CELL BIOLOGY

Seminars in cell & developmental biology

Pub Date : 2025-04-03 DOI: 10.1016/j.semcdb.2025.103606

Junmin Pan

引用次数: 0

The ever-diversifying landscape of intra-genomic conflict 不断多样化的基因组内部冲突

IF 6.2 2区生物学 Q1 CELL BIOLOGY

Seminars in cell & developmental biology

Pub Date : 2025-03-26 DOI: 10.1016/j.semcdb.2025.103603

Mia T. Levine, Sarah E. Zanders

引用次数: 0

Cell death in regeneration and cell turnover: Lessons from planarians and Drosophila 再生和细胞更新中的细胞死亡：来自涡虫和果蝇的教训

IF 6.2 2区生物学 Q1 CELL BIOLOGY

Seminars in cell & developmental biology

Pub Date : 2025-03-25 DOI: 10.1016/j.semcdb.2025.103605

Teresa Adell, Francesc Cebrià, Josep F. Abril, Sofia J. Araújo, Montserrat Corominas, Marta Morey, Florenci Serras, Cristina González-Estévez

Programmed cell death plays a crucial role during tissue turnover in all animal species, and it is also essential during regeneration, serving as a key signalling mechanism to promote tissue repair and regrowth. In freshwater planarians, remarkable regenerative abilities are supported by neoblasts, a population of adult stem cells, which enable high somatic cell turnover. Cell death in planarians occurs continuously during regeneration and adult homeostasis, underscoring its critical role in tissue remodeling and repair. However, the exact mechanisms regulating cell death in these organisms remain elusive. In contrast, Drosophila melanogaster serves as a powerful model for studying programmed cell death in development, metamorphosis, and adult tissue maintenance, leveraging advanced genetic tools and visualization techniques. In Drosophila, cell death sculpts tissues, eliminates larval structures during metamorphosis, and supports homeostasis in adulthood. Despite limited regenerative capacity compared to planarians, Drosophila provides unique insights into cell death's regulatory mechanisms. Comparative analysis of these two systems highlights both conserved and divergent roles of programmed cell death in tissue renewal and regeneration. This review synthesizes the latest knowledge of programmed cell death in planarians and Drosophila, aiming to illuminate shared principles and system-specific adaptations, with relevance to tissue repair across biological systems.

程序性细胞死亡在所有动物物种的组织更新过程中起着至关重要的作用，在再生过程中也是必不可少的，是促进组织修复和再生的关键信号机制。在淡水涡虫中，卓越的再生能力是由新生细胞支持的，新生细胞是一群成体干细胞，能够实现高体细胞周转率。涡虫的细胞死亡在再生和成体稳态过程中不断发生，强调了其在组织重塑和修复中的关键作用。然而，在这些生物体中调节细胞死亡的确切机制仍然是难以捉摸的。相比之下，利用先进的遗传工具和可视化技术，黑腹果蝇可以作为研究发育、变态和成体组织维持过程中程序性细胞死亡的强大模型。在果蝇中，细胞死亡雕刻组织，在蜕变过程中消除幼虫结构，并支持成年期的体内平衡。尽管与涡虫相比，果蝇的再生能力有限，但它对细胞死亡的调控机制提供了独特的见解。这两个系统的比较分析强调了程序性细胞死亡在组织更新和再生中的保守和不同的作用。本综述综合了涡虫和果蝇程序性细胞死亡的最新知识，旨在阐明与生物系统组织修复相关的共同原则和系统特异性适应。

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引用次数: 0

Death fuels growth: Emerging players bridging apoptosis and cell proliferation in Drosophila and beyond 死亡促进生长：在果蝇和其他物种中连接细胞凋亡和细胞增殖的新兴参与者

IF 6.2 2区生物学 Q1 CELL BIOLOGY

Seminars in cell & developmental biology

Pub Date : 2025-03-12 DOI: 10.1016/j.semcdb.2025.103602

Caitlin Hounsell, Yun Fan

Tissue homeostasis relies on a delicate balance between cell death and proliferation. Apoptosis plays a key role not only in removing damaged cells but also in promoting tissue recovery through a process known as apoptosis-induced proliferation (AiP). This review highlights how caspases, c-Jun N-terminal Kinase (JNK), and Reactive Oxygen Species (ROS) bridge cell death and proliferation, as revealed through studies using Drosophila as a model organism. We also compare these findings with advances in other model systems and discuss their broader implications for tissue regeneration and tumorigenesis.

组织稳态依赖于细胞死亡和增殖之间的微妙平衡。细胞凋亡不仅在清除受损细胞中起着关键作用，而且还通过称为凋亡诱导增殖（AiP）的过程促进组织恢复。本文综述了半胱天冬酶、c-Jun n -末端激酶（JNK）和活性氧（ROS）如何架起细胞死亡和增殖的桥梁，这是通过果蝇作为模式生物的研究发现的。我们还将这些发现与其他模型系统的进展进行了比较，并讨论了它们对组织再生和肿瘤发生的更广泛意义。

引用次数: 0

Epithelial apoptosis: A back-and-forth mechanical interplay between the dying cell and its surroundings 上皮细胞凋亡：濒死细胞与周围环境之间来回的机械相互作用

IF 6.2 2区生物学 Q1 CELL BIOLOGY

Seminars in cell & developmental biology

Pub Date : 2025-02-21 DOI: 10.1016/j.semcdb.2025.02.001

Stéphanie Arnould , Corinne Benassayag , Tatiana Merle , Bruno Monier , Marianne Montemurro , Magali Suzanne

Apoptosis is an essential cellular process corresponding to a programmed cell suicide. It has long been considered as a cell-autonomous process, supposed to have no particular impact on the surrounding tissue. However, it has become clear in the last 15 years that epithelial apoptotic cells interact mechanically and biochemically with their environment. Here, we explore recent literature on apoptotic mechanics from an individual dying cell to the back-and-forth interplay with the neighboring epithelial tissue. Finally, we discuss how caspases, key regulators of apoptosis, appear to have a dual function as a cytoskeleton regulator favoring either cytoskeleton degradation or dynamics independently of their apoptotic or non-apoptotic role.

细胞凋亡是细胞程序性自杀的基本过程。长期以来，它一直被认为是一种细胞自主过程，对周围组织没有特别的影响。然而，在过去的15年中，上皮细胞凋亡与环境的机械和生化相互作用已经变得很清楚。在这里，我们探索了最近关于凋亡机制的文献，从单个垂死细胞到与邻近上皮组织的来回相互作用。最后，我们讨论了半胱天冬酶，细胞凋亡的关键调节因子，似乎具有双重功能，作为细胞骨架调节因子，有利于细胞骨架降解或动力学，独立于其凋亡或非凋亡作用。

引用次数: 0

Zebrafish tailfin as an in vivo model for capturing tissue-scale cell dynamics 斑马鱼尾鳍作为捕获组织尺度细胞动力学的体内模型。

IF 6.2 2区生物学 Q1 CELL BIOLOGY

Seminars in cell & developmental biology

Pub Date : 2025-02-01 DOI: 10.1016/j.semcdb.2024.12.005

Yue Rong Tan, Hsiao-Yuh Roan, Chen-Hui Chen

The intricate control of collective cell dynamics is crucial for enabling organismic development and tissue regeneration. Despite the availability of various in vitro and in vivo models, studies on tissue-scale cell dynamics and associated emergent properties in living systems remain methodically challenging. Here, we describe key advantages of using the adult zebrafish tailfin (caudal fin) as a robust in vivo model for dissecting millimeter-scale collective cell dynamics during regeneration and wound healing in a complex tissue. For researchers considering this model system, we briefly introduce the tailfin anatomy, as well as available transgenic reporter tools and live-imaging setups that may be utilized to study epidermal cell behaviors. To highlight the unique strengths of the zebrafish tailfin model, we present an example project that was made possible by techniques for tracking cell dynamics at a millimeter scale with single-cell resolution in live animals. Finally, we discuss the research directions at the interface of collective cell dynamics and regenerative biology that most excite us and can be examined using the tailfin model.

复杂的控制集体细胞动力学是至关重要的，使有机体的发展和组织再生。尽管存在各种体外和体内模型，但对生命系统中组织尺度细胞动力学和相关涌现特性的研究仍然具有系统性的挑战性。在这里，我们描述了使用成年斑马鱼尾鳍作为一个强大的体内模型来解剖复杂组织中再生和伤口愈合过程中毫米尺度的集体细胞动力学的主要优点。对于考虑该模型系统的研究人员，我们简要介绍了尾鳍解剖，以及可用的转基因报告工具和可用于研究表皮细胞行为的实时成像设置。为了突出斑马鱼尾鳍模型的独特优势，我们提出了一个示例项目，该项目通过在活体动物中以单细胞分辨率在毫米尺度上跟踪细胞动力学的技术成为可能。最后，我们讨论了在集体细胞动力学和再生生物学的界面上，最令人兴奋的研究方向，可以用尾翼模型来检验。

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引用次数: 0

Recent advancement in the spatial immuno-oncology 空间免疫肿瘤学的最新进展。

IF 6.2 2区生物学 Q1 CELL BIOLOGY

Seminars in cell & developmental biology

Pub Date : 2025-02-01 DOI: 10.1016/j.semcdb.2024.12.003

Alex To , Zou Yu , Ryohichi Sugimura

Recent advancements in spatial transcriptomics and spatial proteomics enabled the high-throughput profiling of single or multi-cell types and cell states with spatial information. They transformed our understanding of the higher-order architectures and paired cell-cell interactions within a tumor microenvironment (TME). Within less than a decade, this rapidly emerging field has discovered much crucial fundamental knowledge and significantly improved clinical diagnosis in the field of immuno-oncology. This review summarizes the conceptual frameworks to understand spatial omics data and highlights the updated knowledge of spatial immuno-oncology.

空间转录组学和空间蛋白质组学的最新进展使得利用空间信息对单个或多个细胞类型和细胞状态进行高通量分析成为可能。他们改变了我们对肿瘤微环境（TME）中高阶结构和配对细胞-细胞相互作用的理解。在不到十年的时间里，这个快速发展的领域已经发现了许多重要的基础知识，并显著改善了免疫肿瘤学领域的临床诊断。本文综述了理解空间组学数据的概念框架，并重点介绍了空间免疫肿瘤学的最新知识。

引用次数: 0

Collective sperm movement in mammalian reproductive tracts 哺乳动物生殖道中精子的集体运动。

IF 6.2 2区生物学 Q1 CELL BIOLOGY

Seminars in cell & developmental biology

Pub Date : 2025-02-01 DOI: 10.1016/j.semcdb.2024.12.002

Tsuyoshi Hirashima , Sound W.P. , Taichi Noda

Mammalian sperm cells travel from their origin in the male reproductive tract to fertilization in the female tract through a complex process driven by coordinated mechanical and biochemical mechanisms. Recent experimental and theoretical advances have illuminated the collective behaviors of sperm both in vivo and in vitro. However, our understanding of the underlying mechano-chemical processes remains incomplete. This review integrates current insights into sperm group movement, examining both immotile and motile states, which are essential for passive transport and active swimming through the reproductive tracts. We provide an overview of the current understanding of collective sperm movement, focusing on the experimental and theoretical mechanisms behind these behaviors. We also explore how sperm motility is regulated through the coordination of mechanical and chemical processes. Emerging evidence highlights the mechanosensitive properties of a sperm flagellum, suggesting that mechanical stimuli regulate flagellar beating at both individual and collective levels. This self-regulatory, mechano-chemical system reflects a broader principle observed in multicellular systems, offering a system-level insight into the regulation of motility and collective dynamics in biological systems.

哺乳动物精子细胞从雄性生殖道起源到雌性生殖道受精，是一个复杂的过程，由机械和生化机制共同驱动。最近的实验和理论进展已经阐明了精子在体内和体外的集体行为。然而，我们对潜在的机械化学过程的理解仍然不完整。这篇综述整合了目前对精子群运动的见解，研究了静止和运动状态，这是通过生殖道被动运输和主动游动所必需的。我们概述了目前对集体精子运动的理解，重点是这些行为背后的实验和理论机制。我们还探讨了精子运动是如何通过机械和化学过程的协调来调节的。新出现的证据强调了精子鞭毛的机械敏感特性，表明机械刺激在个体和集体水平上调节鞭毛跳动。这种自我调节的机械化学系统反映了在多细胞系统中观察到的更广泛的原理，提供了对生物系统中运动和集体动力学调节的系统级见解。

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引用次数: 0

Collective mechanics of small migrating cell groups 小迁移细胞群的集体机制。

IF 6.2 2区生物学 Q1 CELL BIOLOGY

Seminars in cell & developmental biology

Pub Date : 2025-02-01 DOI: 10.1016/j.semcdb.2024.12.001

Wenzheng Shi , Selena Gupta , Calina Copos , Alex Mogilner

Migration of adhesive cell groups is a fundamental part of wound healing, development and carcinogenesis. Intense research has been conducted on mechanisms of collective migration of adhesive groups of cells. Here we focus on mechanical and mechanistic lessons from small migrating cell groups. We review forces and locomotory dynamics of two- and three-cell clusters, rotation of cell doublets, self-organization of one-dimensional cell trains, nascent efforts to understand three-dimensional collective migration and border cell clusters in Drosophila embryo.

黏附细胞群的迁移是伤口愈合、发展和癌变的基本组成部分。黏附细胞群集体迁移的机制已经得到了广泛的研究。在这里，我们专注于小迁移细胞群的机械和机械经验教训。我们回顾了两细胞和三细胞团的力量和运动动力学，细胞双联体的旋转，一维细胞序列的自组织，了解果蝇胚胎三维集体迁移和边界细胞团的初步努力。

引用次数: 0

Spatiotemporal dissection of collective cell migration and tissue morphogenesis during development by optogenetics 光遗传学对发育过程中集体细胞迁移和组织形态发生的时空解剖。

IF 6.2 2区生物学 Q1 CELL BIOLOGY

Seminars in cell & developmental biology

Pub Date : 2025-02-01 DOI: 10.1016/j.semcdb.2024.12.004

Sijia Zhou , Bing Liu , Jiaying Liu , Bin Yi , Xiaobo Wang

Collective cell migration and tissue morphogenesis play a variety of important roles in the development of many species. Tissue morphogenesis often generates mechanical forces that alter cell shapes and arrangements, resembling collective cell migration-like behaviors. Genetic methods have been widely used to study collective cell migration and its like behavior, advancing our understanding of these processes during development. However, a growing body of research shows that collective cell migration during development is not a simple behavior but is often combined with other cellular and tissue processes. In addition, different surrounding environments can also influence migrating cells, further complicating collective cell migration during development. Due to the complexity of developmental processes and tissues, traditional genetic approaches often encounter challenges and limitations. Thus, some methods with spatiotemporal control become urgent in dissecting collective cell migration and tissue morphogenesis during development. Optogenetics is a method that combines optics and genetics, providing a perfect strategy for spatiotemporally controlling corresponding protein activity in subcellular, cellular or tissue levels. In this review, we introduce the basic mechanisms underlying different optogenetic tools. Then, we demonstrate how optogenetic methods have been applied in vivo to dissect collective cell migration and tissue morphogenesis during development. Additionally, we describe some promising optogenetic approaches for advancing this field. Together, this review will guide and facilitate future studies of collective cell migration in vivo and tissue morphogenesis by optogenetics.

集体细胞迁移和组织形态发生在许多物种的发育中起着各种重要作用。组织形态发生经常产生改变细胞形状和排列的机械力，类似于集体细胞迁移行为。遗传方法已被广泛用于研究细胞集体迁移及其类似行为，促进了我们对这些过程的理解。然而，越来越多的研究表明，在发育过程中，集体细胞迁移不是一种简单的行为，而是经常与其他细胞和组织过程相结合。此外，不同的周围环境也会影响细胞的迁移，使发育过程中的集体细胞迁移进一步复杂化。由于发育过程和组织的复杂性，传统的遗传方法经常遇到挑战和局限性。因此，研究细胞在发育过程中的集体迁移和组织形态发生，迫切需要一些具有时空控制的方法。光遗传学是一种将光学和遗传学相结合的方法，为在亚细胞、细胞或组织水平上对相应的蛋白质活性进行时空控制提供了一种完美的策略。在本文中，我们介绍了不同光遗传学工具的基本机制。然后，我们展示了如何在体内应用光遗传学方法来解剖发育过程中的集体细胞迁移和组织形态发生。此外，我们描述了一些有前途的光遗传学方法来推进这一领域。本文综述将指导和促进光遗传学在体内集体细胞迁移和组织形态发生方面的进一步研究。

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引用次数: 0

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全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

Seminars in cell & developmental biology

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