首页 > 最新文献

Skeletal Radiology最新文献

英文 中文
An unusual case of nodular fasciitis presenting as an intra-tendinous mass. 一例不寻常的结节性筋膜炎病例,表现为肌腱内肿块。
IF 1.9 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-02-01 Epub Date: 2024-06-18 DOI: 10.1007/s00256-024-04728-x
Sisith Ariyaratne, Adesegun Abudu, Vaiyapuri Sumathi, Rajesh Botchu, Christine Azzopardi

Nodular fasciitis is a benign soft tissue pseudotumour typically occurring in the upper extremities, head and neck, thigh and trunk. It is most commonly seen in subcutaneous locations but also can be present in intramuscular and intermuscular (fascial) locations. Its occurrence in the hand is rare, and while it can occur in close proximity to tendons, its presentation as an intra-tendinous mass has not been previously described. We present a unique and rare case of nodular fasciitis arising within the flexor digitorum profundus (FDP) tendon of the hand in a 16-year-old female. The patient presented with a painful swelling in the volar aspect of the base of her left middle finger, with progressive flexion deformity of the finger. Ultrasound and magnetic resonance imaging revealed a mass within the FDP tendon of the middle finger. An ultrasound-guided biopsy revealed a diagnosis of nodular fasciitis. Given the self-limiting nature of the condition, she was managed conservatively with close clinical and imaging follow-up. This case highlights the importance of considering nodular fasciitis in the differential diagnosis of an intra-tendinous lesion in the hand, even though it is a rare occurrence in this location. The clinical presentation, diagnostic workup, and management of this unique case are discussed, emphasising the potential for its misdiagnosis as a malignancy which can have important implications in management.

结节性筋膜炎是一种良性软组织假瘤,通常发生在上肢、头颈部、大腿和躯干。它最常见于皮下部位,但也可出现在肌肉内和肌肉间(筋膜)部位。它在手部的发病率很低,虽然可以发生在靠近肌腱的部位,但以肌腱内肿块的形式出现在手部的病例以前从未有过描述。我们介绍了一例独特而罕见的结节性筋膜炎病例,患者是一名 16 岁女性,手部屈指肌腱(FDP)内出现结节性筋膜炎。患者左手中指根部外侧肿胀疼痛,手指逐渐屈曲畸形。超声波和磁共振成像显示中指FDP肌腱内有肿块。超声引导下的活检显示诊断为结节性筋膜炎。鉴于该病具有自限性,她接受了保守治疗,并进行了密切的临床和影像学随访。本病例强调了在手部肌腱内病变的鉴别诊断中考虑结节性筋膜炎的重要性,尽管这种病变在该部位很少见。本文讨论了这一独特病例的临床表现、诊断工作和处理方法,强调了将其误诊为恶性肿瘤的可能性,这可能会对治疗产生重要影响。
{"title":"An unusual case of nodular fasciitis presenting as an intra-tendinous mass.","authors":"Sisith Ariyaratne, Adesegun Abudu, Vaiyapuri Sumathi, Rajesh Botchu, Christine Azzopardi","doi":"10.1007/s00256-024-04728-x","DOIUrl":"10.1007/s00256-024-04728-x","url":null,"abstract":"<p><p>Nodular fasciitis is a benign soft tissue pseudotumour typically occurring in the upper extremities, head and neck, thigh and trunk. It is most commonly seen in subcutaneous locations but also can be present in intramuscular and intermuscular (fascial) locations. Its occurrence in the hand is rare, and while it can occur in close proximity to tendons, its presentation as an intra-tendinous mass has not been previously described. We present a unique and rare case of nodular fasciitis arising within the flexor digitorum profundus (FDP) tendon of the hand in a 16-year-old female. The patient presented with a painful swelling in the volar aspect of the base of her left middle finger, with progressive flexion deformity of the finger. Ultrasound and magnetic resonance imaging revealed a mass within the FDP tendon of the middle finger. An ultrasound-guided biopsy revealed a diagnosis of nodular fasciitis. Given the self-limiting nature of the condition, she was managed conservatively with close clinical and imaging follow-up. This case highlights the importance of considering nodular fasciitis in the differential diagnosis of an intra-tendinous lesion in the hand, even though it is a rare occurrence in this location. The clinical presentation, diagnostic workup, and management of this unique case are discussed, emphasising the potential for its misdiagnosis as a malignancy which can have important implications in management.</p>","PeriodicalId":21783,"journal":{"name":"Skeletal Radiology","volume":" ","pages":"367-371"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141420790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of axial loading and positions on lumbar spinal stenosis: an MRI study using a new axial loading device. 轴向加载和体位对腰椎管狭窄症的影响:使用新型轴向加载装置进行的磁共振成像研究。
IF 1.9 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-02-01 Epub Date: 2024-06-07 DOI: 10.1007/s00256-024-04720-5
Xingyu Fang, Mengqiu Cui, Yingwei Wang, Lin Liu, Wei Lv, Huiyi Ye, Gang Liu

Objective: A new axial loading device was used to investigate the effects of axial loading and positions on lumbar structure and lumbar spinal stenosis.

Methods: A total of 40 patients sequentially underwent 4 examinations: (1) the psoas-relaxed position MRI, (2) the extended position MRI, (3) the psoas-relaxed position axial loading MRI, (4) the extended position axial loading MRI. The dural sac cross-sectional area, sagittal vertebral canal diameter, disc height and ligamentum flavum thickness of L3-4, L4-5, L5-S1 and lumbar lordosis angle were measured and compared. A new device with pneumatic shoulder-hip compression mode was used for axial loading.

Results: In the absence of axial loading, there was a significant reduction in dural sac cross-sectional area with extension only seen at the L3-4 (p = 0.033) relative to the dural sac area in the psoas-relaxed position. However, with axial loading, there was a significant reduction in dural sac cross-sectional area at all levels in both psoas-relaxed (L3-4, p = 0.041; L5-S1, p = 0.005; L4-5, p = 0.002) and extension (p < 0.001) positions. The sagittal vertebral canal diameter and disc height were significantly reduced at all lumbar levels with axial loading and extension (p < 0.001); however, in psoas-relaxed position, the sagittal vertebral canal diameter was only reduced with axial loading at L3-4 (p = 0.018) and L4-5 (p = 0.011), and the disc height was reduced with axial-loading at all levels (L3-4, p = 0.027; L5-S1, p = 0.001; L4-5, p < 0.001). The ligamentum flavum thickness and lumbar lordosis in extension position had a statistically significant increase compared to psoas-relaxed position with or without axial loading (p < 0.001).

Conclusion: Both axial loading and extension of lumbar may exacerbate lumbar spinal stenosis. Axial loading in extension position could maximally aggravate lumbar spinal stenosis, but may cause some patients intolerable. For those patients, axial loading MRI in psoas-relaxed position may be a good choice.

目的采用新型轴向加载装置研究轴向加载和体位对腰椎结构和腰椎管狭窄症的影响:共有 40 名患者依次接受了 4 次检查:(1) 腰肌放松位核磁共振成像;(2) 腰肌伸展位核磁共振成像;(3) 腰肌放松位轴向加载核磁共振成像;(4) 腰肌伸展位轴向加载核磁共振成像。测量并比较了 L3-4、L4-5、L5-S1 的硬膜囊横截面积、矢状椎管直径、椎间盘高度和黄韧带厚度以及腰椎前凸角度。结果显示:在没有轴向负荷的情况下,腰椎间盘的高度和黄韧带的厚度均有所增加:结果:在无轴向负荷的情况下,与腰肌放松位置的硬膜囊面积相比,仅 L3-4 硬膜囊的横截面积随着伸展而显著缩小(p = 0.033)。然而,在轴向负荷下,腰肌松弛位置(L3-4,p = 0.041;L5-S1,p = 0.005;L4-5,p = 0.002)和伸展位置(p < 0.001)的硬膜囊横截面积在所有级别都有显著减少。所有腰椎级别的椎管矢状面直径和椎间盘高度在轴向加载和伸展时均显著降低(p < 0.001);然而,在腰肌放松体位下,椎管矢状面直径仅在L3-4(p = 0.018) 和 L4-5 (p = 0.011),椎间盘高度在所有水平上都随着轴向负荷而降低(L3-4,p = 0.027;L5-S1,p = 0.001;L4-5,p < 0.001)。黄韧带厚度和腰椎前凸在伸展位置与腰肌放松位置相比,无论有无轴向负荷,均有统计学意义上的显著增加(p < 0.001):结论:腰椎的轴向负荷和伸展都可能加重腰椎管狭窄。结论:轴向加载和腰椎伸展都可能加重腰椎管狭窄。伸展位的轴向加载可最大程度地加重腰椎管狭窄,但可能导致部分患者无法忍受。对于这些患者,腰肌放松位的轴向负荷 MRI 可能是一个不错的选择。
{"title":"Effects of axial loading and positions on lumbar spinal stenosis: an MRI study using a new axial loading device.","authors":"Xingyu Fang, Mengqiu Cui, Yingwei Wang, Lin Liu, Wei Lv, Huiyi Ye, Gang Liu","doi":"10.1007/s00256-024-04720-5","DOIUrl":"10.1007/s00256-024-04720-5","url":null,"abstract":"<p><strong>Objective: </strong>A new axial loading device was used to investigate the effects of axial loading and positions on lumbar structure and lumbar spinal stenosis.</p><p><strong>Methods: </strong>A total of 40 patients sequentially underwent 4 examinations: (1) the psoas-relaxed position MRI, (2) the extended position MRI, (3) the psoas-relaxed position axial loading MRI, (4) the extended position axial loading MRI. The dural sac cross-sectional area, sagittal vertebral canal diameter, disc height and ligamentum flavum thickness of L3-4, L4-5, L5-S1 and lumbar lordosis angle were measured and compared. A new device with pneumatic shoulder-hip compression mode was used for axial loading.</p><p><strong>Results: </strong>In the absence of axial loading, there was a significant reduction in dural sac cross-sectional area with extension only seen at the L3-4 (p = 0.033) relative to the dural sac area in the psoas-relaxed position. However, with axial loading, there was a significant reduction in dural sac cross-sectional area at all levels in both psoas-relaxed (L3-4, p = 0.041; L5-S1, p = 0.005; L4-5, p = 0.002) and extension (p < 0.001) positions. The sagittal vertebral canal diameter and disc height were significantly reduced at all lumbar levels with axial loading and extension (p < 0.001); however, in psoas-relaxed position, the sagittal vertebral canal diameter was only reduced with axial loading at L3-4 (p = 0.018) and L4-5 (p = 0.011), and the disc height was reduced with axial-loading at all levels (L3-4, p = 0.027; L5-S1, p = 0.001; L4-5, p < 0.001). The ligamentum flavum thickness and lumbar lordosis in extension position had a statistically significant increase compared to psoas-relaxed position with or without axial loading (p < 0.001).</p><p><strong>Conclusion: </strong>Both axial loading and extension of lumbar may exacerbate lumbar spinal stenosis. Axial loading in extension position could maximally aggravate lumbar spinal stenosis, but may cause some patients intolerable. For those patients, axial loading MRI in psoas-relaxed position may be a good choice.</p>","PeriodicalId":21783,"journal":{"name":"Skeletal Radiology","volume":" ","pages":"199-208"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141288557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk factors for false positive and false negative MRI in diagnosing medial and lateral meniscal tears with concomitant ACL injury. 在诊断前交叉韧带损伤的内侧和外侧半月板撕裂时,磁共振成像出现假阳性和假阴性的风险因素。
IF 1.9 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-02-01 Epub Date: 2024-07-08 DOI: 10.1007/s00256-024-04745-w
Stephanie Chahwan, Charlotte Charbel, Esther Tannoury, Anthony El Alam, Joeffroy Otayek, Joe Ghanimeh, Alfred Khoury, Pascale Salameh, Sahar Semaan

Objective: To determine the diagnostic performance of MRI in evaluating meniscal abnormalities in the setting of anterior cruciate ligament (ACL) injury and recognize predictors of false positive (FP) and false negative (FN) MRI diagnosis.

Material and methods: Four hundred twenty patients (mean age, 27.2 years; 326 males, 94 females) who underwent arthroscopy for ACL injury between January 2017 and August 2022, and had preoperative imaging within 4 months, were retrospectively included. Images were independently interpreted by two experienced musculoskeletal radiologists, noting the presence of medial and lateral meniscal tears including tear type and location. Results were correlated with arthroscopic findings. Multivariate logistic regression was implemented to study risk factors (RF) for FP and FN MRI diagnosis.

Results: The sensitivity/specificity/positive predictive value/negative predictive value/accuracy of MRI for medial meniscus tear was 97.5%/74.46%/65.63%/98.35%/82.15%; for lateral meniscus tear, it was 83.5%/93.70%/70.8%/94.55% /87.86%, with substantial interreader agreement. Female gender (odds ratio (OR), 0.434), posterior horn and posterior root tears (OR, 3.268/22.588), horizontal tear (OR, 3.134), and ramp lesion (OR, 4.964) were found RF for FP medial meniscus, and meniscal body tears (OR, 308.011) were found RF for FP lateral meniscus. RF for FN medial meniscus were meniscal tear at the posterior horn, body, and posterior root (OR, 12.371/123.000/13.045).

Conclusion: MRI is an effective screening tool for meniscal tears, but less accurate in detecting all medial meniscus injuries. Gender, meniscal tear location, and type increased the risk of FP medial meniscal tear on MRI, while meniscal tear location increased the risk of FP lateral meniscus and FN medial meniscus tears.

目的确定 MRI 在评估前交叉韧带(ACL)损伤时半月板异常的诊断性能,并识别 MRI 假阳性(FP)和假阴性(FN)诊断的预测因素:回顾性纳入2017年1月至2022年8月期间因前交叉韧带损伤接受关节镜手术的420例患者(平均年龄27.2岁;男性326例,女性94例),这些患者在4个月内接受过术前影像学检查。图像由两名经验丰富的肌肉骨骼放射科医生独立解读,注意是否存在内侧和外侧半月板撕裂,包括撕裂类型和位置。结果与关节镜检查结果相关。采用多变量逻辑回归法研究FP和FN MRI诊断的风险因素(RF):结果:MRI对内侧半月板撕裂的敏感性/特异性/阳性预测值/阴性预测值/准确性分别为97.5%/74.46%/65.63%/98.35%/82.15%;对外侧半月板撕裂的敏感性/特异性/阳性预测值/阴性预测值/准确性分别为83.5%/93.70%/70.8%/94.55%/87.86%,读片者之间的一致性很高。发现女性性别(比值比(OR),0.434)、后角和后根撕裂(OR,3.268/22.588)、水平撕裂(OR,3.134)和斜坡病变(OR,4.964)是FP内侧半月板的RF,半月板体撕裂(OR,308.011)是FP外侧半月板的RF。FN内侧半月板的RF为半月板后角、本体和后根部撕裂(OR,12.371/123.000/13.045):结论:磁共振成像是筛查半月板撕裂的有效工具,但在检测所有内侧半月板损伤方面的准确性较低。性别、半月板撕裂位置和类型会增加 MRI 上 FP 内侧半月板撕裂的风险,而半月板撕裂位置会增加 FP 外侧半月板和 FN 内侧半月板撕裂的风险。
{"title":"Risk factors for false positive and false negative MRI in diagnosing medial and lateral meniscal tears with concomitant ACL injury.","authors":"Stephanie Chahwan, Charlotte Charbel, Esther Tannoury, Anthony El Alam, Joeffroy Otayek, Joe Ghanimeh, Alfred Khoury, Pascale Salameh, Sahar Semaan","doi":"10.1007/s00256-024-04745-w","DOIUrl":"10.1007/s00256-024-04745-w","url":null,"abstract":"<p><strong>Objective: </strong>To determine the diagnostic performance of MRI in evaluating meniscal abnormalities in the setting of anterior cruciate ligament (ACL) injury and recognize predictors of false positive (FP) and false negative (FN) MRI diagnosis.</p><p><strong>Material and methods: </strong>Four hundred twenty patients (mean age, 27.2 years; 326 males, 94 females) who underwent arthroscopy for ACL injury between January 2017 and August 2022, and had preoperative imaging within 4 months, were retrospectively included. Images were independently interpreted by two experienced musculoskeletal radiologists, noting the presence of medial and lateral meniscal tears including tear type and location. Results were correlated with arthroscopic findings. Multivariate logistic regression was implemented to study risk factors (RF) for FP and FN MRI diagnosis.</p><p><strong>Results: </strong>The sensitivity/specificity/positive predictive value/negative predictive value/accuracy of MRI for medial meniscus tear was 97.5%/74.46%/65.63%/98.35%/82.15%; for lateral meniscus tear, it was 83.5%/93.70%/70.8%/94.55% /87.86%, with substantial interreader agreement. Female gender (odds ratio (OR), 0.434), posterior horn and posterior root tears (OR, 3.268/22.588), horizontal tear (OR, 3.134), and ramp lesion (OR, 4.964) were found RF for FP medial meniscus, and meniscal body tears (OR, 308.011) were found RF for FP lateral meniscus. RF for FN medial meniscus were meniscal tear at the posterior horn, body, and posterior root (OR, 12.371/123.000/13.045).</p><p><strong>Conclusion: </strong>MRI is an effective screening tool for meniscal tears, but less accurate in detecting all medial meniscus injuries. Gender, meniscal tear location, and type increased the risk of FP medial meniscal tear on MRI, while meniscal tear location increased the risk of FP lateral meniscus and FN medial meniscus tears.</p>","PeriodicalId":21783,"journal":{"name":"Skeletal Radiology","volume":" ","pages":"303-315"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Degenerative medial and lateral menisci root tears: demographics, clinical presentation, imaging features, and associated findings. 内侧和外侧半月板根部退行性撕裂:人口统计学、临床表现、影像学特征和相关发现。
IF 1.9 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-02-01 Epub Date: 2024-06-25 DOI: 10.1007/s00256-024-04724-1
Julio B Guimaraes, Rawee Manatrakul, Gabby B Joseph, Brian Feeley, Drew A Lansdown, Joshua V Chen, Joe D Baal, Thomas M Link

Purpose: (I) Characterize the demographics and clinical features of patients with meniscal root tears (MRT); (II) analyze the morphology, extent, and grade of MRT on MRI; (III) evaluate associated abnormalities on imaging; and (IV) evaluate the associations between imaging findings, demographics, clinical features, and joint structural abnormalities.

Material and methods: A search was performed to identify meniscal root tears. Age, sex, BMI, and pain were recorded. Knee radiographs and MRI were reviewed. Presence, grade and morphology of MRT, meniscal extrusion, insufficiency fractures, as well as joint structural abnormalities were scored. For goals (I), (II), and (III), tabulations for categorical variables and mean for continuous variables were computed. MRT findings variables were described using percentages. For goal (IV), adjusted linear and logistic regression were employed.

Results: Ninety-six patients with a mean age of 56.6 years (69 females) and mean BMI of 28.9 kg/m2 were included; 88 of the MRT were located at the posterior horn of the medial meniscus (PHMM), and 82% were radial tear. The mean tear diameter was 3.8 mm, and 78/96 tears presented with meniscal extrusion. Nineteen patients presented with subchondral insufficiency fracture (SIF), which was significantly associated with the gap of the tear (p = 0.001) and grade of the meniscal root lesion (p = 0.005).

Conclusion: MRT typically found in middle-aged to older overweight and obese women. Lesions were mostly radial tears and located at PHMM and were frequently associated with meniscal extrusion and SIF. Moreover, the presence of SIF was significantly associated with the gap width and grade of root tear.

目的:(I)描述半月板根撕裂(MRT)患者的人口统计学特征和临床特征;(II)分析 MRT 在 MRI 上的形态、范围和分级;(III)评估影像学上的相关异常;以及(IV)评估影像学结果、人口统计学特征、临床特征和关节结构异常之间的关联:对半月板根撕裂进行检索。记录年龄、性别、体重指数和疼痛。对膝关节X光片和核磁共振成像进行复查。对MRT、半月板挤压、损伤性骨折以及关节结构异常的存在、等级和形态进行评分。对于目标(I)、(II)和(III),计算分类变量的表格和连续变量的平均值。MRT 结果变量采用百分比描述。对于目标(IV),采用了调整线性回归和逻辑回归:96名患者的平均年龄为56.6岁(69名女性),平均体重指数为28.9 kg/m2;88例MRT位于内侧半月板后角(PHMM),82%为径向撕裂。平均撕裂直径为3.8毫米,78/96的撕裂伴有半月板挤压。19名患者出现软骨下不全骨折(SIF),这与撕裂的间隙(P = 0.001)和半月板根部病变的等级(P = 0.005)显著相关:结论:MRT通常见于中老年超重和肥胖女性。结论:MRT通常发生在中老年超重和肥胖女性身上,病变多为径向撕裂,位于PHMM,常伴有半月板挤压和SIF。此外,SIF的存在与间隙宽度和根部撕裂等级有显著相关性。
{"title":"Degenerative medial and lateral menisci root tears: demographics, clinical presentation, imaging features, and associated findings.","authors":"Julio B Guimaraes, Rawee Manatrakul, Gabby B Joseph, Brian Feeley, Drew A Lansdown, Joshua V Chen, Joe D Baal, Thomas M Link","doi":"10.1007/s00256-024-04724-1","DOIUrl":"10.1007/s00256-024-04724-1","url":null,"abstract":"<p><strong>Purpose: </strong>(I) Characterize the demographics and clinical features of patients with meniscal root tears (MRT); (II) analyze the morphology, extent, and grade of MRT on MRI; (III) evaluate associated abnormalities on imaging; and (IV) evaluate the associations between imaging findings, demographics, clinical features, and joint structural abnormalities.</p><p><strong>Material and methods: </strong>A search was performed to identify meniscal root tears. Age, sex, BMI, and pain were recorded. Knee radiographs and MRI were reviewed. Presence, grade and morphology of MRT, meniscal extrusion, insufficiency fractures, as well as joint structural abnormalities were scored. For goals (I), (II), and (III), tabulations for categorical variables and mean for continuous variables were computed. MRT findings variables were described using percentages. For goal (IV), adjusted linear and logistic regression were employed.</p><p><strong>Results: </strong>Ninety-six patients with a mean age of 56.6 years (69 females) and mean BMI of 28.9 kg/m<sup>2</sup> were included; 88 of the MRT were located at the posterior horn of the medial meniscus (PHMM), and 82% were radial tear. The mean tear diameter was 3.8 mm, and 78/96 tears presented with meniscal extrusion. Nineteen patients presented with subchondral insufficiency fracture (SIF), which was significantly associated with the gap of the tear (p = 0.001) and grade of the meniscal root lesion (p = 0.005).</p><p><strong>Conclusion: </strong>MRT typically found in middle-aged to older overweight and obese women. Lesions were mostly radial tears and located at PHMM and were frequently associated with meniscal extrusion and SIF. Moreover, the presence of SIF was significantly associated with the gap width and grade of root tear.</p>","PeriodicalId":21783,"journal":{"name":"Skeletal Radiology","volume":" ","pages":"255-266"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Test yourself answer: Left knee pain in a young adult. 测试自己的答案:一名年轻成年人的左膝疼痛。
IF 1.9 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-02-01 Epub Date: 2024-07-20 DOI: 10.1007/s00256-024-04750-z
S Agarwal, K Shirodkar, M Hussein, R Henderson, A Kanani, S Vaiyapuri, R Botchu
{"title":"Test yourself answer: Left knee pain in a young adult.","authors":"S Agarwal, K Shirodkar, M Hussein, R Henderson, A Kanani, S Vaiyapuri, R Botchu","doi":"10.1007/s00256-024-04750-z","DOIUrl":"10.1007/s00256-024-04750-z","url":null,"abstract":"","PeriodicalId":21783,"journal":{"name":"Skeletal Radiology","volume":" ","pages":"379-382"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141731403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erdheim-Chester disease and nuclear medicine imaging. A case report and brief review. 埃尔德海姆-切斯特病与核医学成像。病例报告和简要回顾。
IF 1.9 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-02-01 Epub Date: 2024-06-06 DOI: 10.1007/s00256-024-04718-z
D Bountas, M Bountas, P Exadactylou, C Tziafalia, C Dimitriadis, A Doumas

Erdheim-Chester disease (ECD) is a rare clonal myeloid neoplasm typically affecting adults over 50 years old, with bone lesions in almost all patients. The prognosis is poor in most cases if left untreated. Clinical manifestations are not specific, which hinders early diagnosis. The disease has distinct radiological features. However, three-phase bone scintigraphy exhibits the most typical pattern of all imaging modalities, which is the prominent strikingly symmetrical radiotracer uptake in the distal ends of the femurs and proximal and distal ends of the tibiae, sparing the epiphyses. We report a case of a 54-year-old female patient, presenting with atypical persistent knee joint pain. After an MRI scan, she underwent a three-phase bone scan, revealing the characteristic pattern, thus indicating a possible ECD diagnosis, which was eventually confirmed in biopsy material. Novel aspects of the pathophysiology and treatment of the disease, as well as a differential diagnosis from the perspective of an MSK radiologist and nuclear medicine physician, are also discussed.

埃尔德海姆-切斯特病(Erdheim-Chester disease,ECD)是一种罕见的克隆性髓细胞肿瘤,通常影响 50 岁以上的成年人,几乎所有患者都有骨病变。如果不及时治疗,大多数病例的预后都很差。临床表现没有特异性,妨碍了早期诊断。该病有明显的放射学特征。然而,三相骨闪烁扫描显示出所有成像模式中最典型的模式,即股骨远端和胫骨近端及远端显著对称的放射性示踪剂摄取,而骺端不摄取。我们报告了一例 54 岁的女性患者,她出现了非典型的持续性膝关节疼痛。在接受核磁共振成像扫描后,她又接受了三相骨扫描,结果显示出特征性的模式,从而提示可能的 ECD 诊断,并最终在活检材料中得到证实。本文还从一名 MSK 放射科医生和核医学医生的角度,讨论了该病病理生理学和治疗的新方面以及鉴别诊断。
{"title":"Erdheim-Chester disease and nuclear medicine imaging. A case report and brief review.","authors":"D Bountas, M Bountas, P Exadactylou, C Tziafalia, C Dimitriadis, A Doumas","doi":"10.1007/s00256-024-04718-z","DOIUrl":"10.1007/s00256-024-04718-z","url":null,"abstract":"<p><p>Erdheim-Chester disease (ECD) is a rare clonal myeloid neoplasm typically affecting adults over 50 years old, with bone lesions in almost all patients. The prognosis is poor in most cases if left untreated. Clinical manifestations are not specific, which hinders early diagnosis. The disease has distinct radiological features. However, three-phase bone scintigraphy exhibits the most typical pattern of all imaging modalities, which is the prominent strikingly symmetrical radiotracer uptake in the distal ends of the femurs and proximal and distal ends of the tibiae, sparing the epiphyses. We report a case of a 54-year-old female patient, presenting with atypical persistent knee joint pain. After an MRI scan, she underwent a three-phase bone scan, revealing the characteristic pattern, thus indicating a possible ECD diagnosis, which was eventually confirmed in biopsy material. Novel aspects of the pathophysiology and treatment of the disease, as well as a differential diagnosis from the perspective of an MSK radiologist and nuclear medicine physician, are also discussed.</p>","PeriodicalId":21783,"journal":{"name":"Skeletal Radiology","volume":" ","pages":"359-365"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141262902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Whole-body low-dose computed tomography in patients with newly diagnosed multiple myeloma predicts cytogenetic risk: a deep learning radiogenomics study. 新诊断多发性骨髓瘤患者的全身低剂量计算机断层扫描可预测细胞遗传风险:一项深度学习放射基因组学研究。
IF 1.9 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-02-01 Epub Date: 2024-06-27 DOI: 10.1007/s00256-024-04733-0
Shahriar Faghani, Mana Moassefi, Udit Yadav, Francis K Buadi, Shaji K Kumar, Bradley J Erickson, Wilson I Gonsalves, Francis I Baffour

Objective: To develop a whole-body low-dose CT (WBLDCT) deep learning model and determine its accuracy in predicting the presence of cytogenetic abnormalities in multiple myeloma (MM).

Materials and methods: WBLDCTs of MM patients performed within a year of diagnosis were included. Cytogenetic assessments of clonal plasma cells via fluorescent in situ hybridization (FISH) were used to risk-stratify patients as high-risk (HR) or standard-risk (SR). Presence of any of del(17p), t(14;16), t(4;14), and t(14;20) on FISH was defined as HR. The dataset was evenly divided into five groups (folds) at the individual patient level for model training. Mean and standard deviation (SD) of the area under the receiver operating curve (AUROC) across the folds were recorded.

Results: One hundred fifty-one patients with MM were included in the study. The model performed best for t(4;14), mean (SD) AUROC of 0.874 (0.073). The lowest AUROC was observed for trisomies: AUROC of 0.717 (0.058). Two- and 5-year survival rates for HR cytogenetics were 87% and 71%, respectively, compared to 91% and 79% for SR cytogenetics. Survival predictions by the WBLDCT deep learning model revealed 2- and 5-year survival rates for patients with HR cytogenetics as 87% and 71%, respectively, compared to 92% and 81% for SR cytogenetics.

Conclusion: A deep learning model trained on WBLDCT scans predicted the presence of cytogenetic abnormalities used for risk stratification in MM. Assessment of the model's performance revealed good to excellent classification of the various cytogenetic abnormalities.

目的开发全身低剂量 CT(WBLDCT)深度学习模型,并确定其预测多发性骨髓瘤(MM)细胞遗传学异常的准确性:纳入了MM患者在确诊后一年内进行的WBLDCT检查。通过荧光原位杂交(FISH)对克隆浆细胞进行细胞遗传学评估,将患者分为高危(HR)和标准危(SR)。FISH检测中出现del(17p)、t(14;16)、t(4;14)和t(14;20)的患者被定义为HR。在患者个体水平上,数据集被平均分为五组(折叠),用于模型训练。记录各组接收者操作曲线下面积(AUROC)的平均值和标准偏差(SD):研究共纳入 151 名 MM 患者。t(4;14)模型表现最佳,平均(标清)AUROC为0.874(0.073)。三染色体的 AUROC 最低:AUROC为0.717(0.058)。HR细胞遗传学的2年和5年生存率分别为87%和71%,而SR细胞遗传学的2年和5年生存率分别为91%和79%。WBLDCT深度学习模型的生存预测显示,HR细胞遗传学患者的2年和5年生存率分别为87%和71%,而SR细胞遗传学患者的2年和5年生存率分别为92%和81%:在WBLDCT扫描基础上训练的深度学习模型可预测用于MM风险分层的细胞遗传学异常的存在。对模型性能的评估显示,该模型对各种细胞遗传学异常进行了良好到卓越的分类。
{"title":"Whole-body low-dose computed tomography in patients with newly diagnosed multiple myeloma predicts cytogenetic risk: a deep learning radiogenomics study.","authors":"Shahriar Faghani, Mana Moassefi, Udit Yadav, Francis K Buadi, Shaji K Kumar, Bradley J Erickson, Wilson I Gonsalves, Francis I Baffour","doi":"10.1007/s00256-024-04733-0","DOIUrl":"10.1007/s00256-024-04733-0","url":null,"abstract":"<p><strong>Objective: </strong>To develop a whole-body low-dose CT (WBLDCT) deep learning model and determine its accuracy in predicting the presence of cytogenetic abnormalities in multiple myeloma (MM).</p><p><strong>Materials and methods: </strong>WBLDCTs of MM patients performed within a year of diagnosis were included. Cytogenetic assessments of clonal plasma cells via fluorescent in situ hybridization (FISH) were used to risk-stratify patients as high-risk (HR) or standard-risk (SR). Presence of any of del(17p), t(14;16), t(4;14), and t(14;20) on FISH was defined as HR. The dataset was evenly divided into five groups (folds) at the individual patient level for model training. Mean and standard deviation (SD) of the area under the receiver operating curve (AUROC) across the folds were recorded.</p><p><strong>Results: </strong>One hundred fifty-one patients with MM were included in the study. The model performed best for t(4;14), mean (SD) AUROC of 0.874 (0.073). The lowest AUROC was observed for trisomies: AUROC of 0.717 (0.058). Two- and 5-year survival rates for HR cytogenetics were 87% and 71%, respectively, compared to 91% and 79% for SR cytogenetics. Survival predictions by the WBLDCT deep learning model revealed 2- and 5-year survival rates for patients with HR cytogenetics as 87% and 71%, respectively, compared to 92% and 81% for SR cytogenetics.</p><p><strong>Conclusion: </strong>A deep learning model trained on WBLDCT scans predicted the presence of cytogenetic abnormalities used for risk stratification in MM. Assessment of the model's performance revealed good to excellent classification of the various cytogenetic abnormalities.</p>","PeriodicalId":21783,"journal":{"name":"Skeletal Radiology","volume":" ","pages":"267-273"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of tibial slope alterations with anterior cruciate ligament (ACL) injury and mucoid degeneration. 胫骨坡度改变与前十字韧带(ACL)损伤和粘液变性的关系。
IF 1.9 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-02-01 Epub Date: 2024-07-17 DOI: 10.1007/s00256-024-04744-x
Varun Ravi, Mahad Rehman, Shuda Xia, Avneesh Chhabra, Flavio Duarte Silva

Objective: To compare radiographic measurements of lateral tibial slope (LTS), medial TS (MTS), and coronal TS (CTS) in MRI-defined intact, injured, and mucoid-degenerated native ACL knees and determine inter-reader reliability.

Materials and methods: Patient records from 2 years at tertiary care hospitals were reviewed for individuals aged 18-100 undergoing 3-Tesla knee MRI and radiographs. Two randomly selected cohorts, control, and pathologic ACLs on MRI with 86 patients each, were age, gender, and BMI-matched. A fellowship-trained musculoskeletal radiologist reevaluated curated images, characterizing ACL status. Two trained medical students independently collected clinical data and measured slopes on blinded radiographs. ICC, Cohen's kappa, and case-control matching were performed using SPSS statistical package, with ICC and ANOVA used for comparisons.

Results: Among 172 patients with 172 MRIs and radiographs, there were 86 controls and 86 ACL lesions. There were 108/172 (62.79%) males and 64/172 (37.21%) females. ICCs were 0.966 for MTS, 0.975 for LTS, and 0.978 for CTS. Mucoid degeneration patients had a higher BMI and were older than control (p < .05) or completely torn (p < .001) ACL patients. There was no difference in TS between normal and pathologic ACLs; however, LTS-MTS differences were larger with partial tears (2.5 ± 4.9) than normal ACLs by 4.5° (± 1.2, p < .001), complete tears by 4.5° (± 1.3, p < .001), and mucoid degeneration by 4.9° (± 1.5, p = .001).

Conclusion: Various TS measurements are reliable. LTS-MTS differences are associated with different ACL lesions compared to normal ACLs.

目的比较 MRI 定义的完好、损伤和粘液变性的原发性前交叉韧带膝关节的胫骨外侧斜度 (LTS)、内侧 TS (MTS) 和冠状 TS (CTS) 的影像学测量值,并确定读片者之间的可靠性:对三甲医院两年来接受 3-Tesla 膝关节 MRI 和 X 光片检查的 18-100 岁患者的病历进行回顾。随机选取了两个组群,即对照组和核磁共振检查出病态前交叉韧带的组群,每个组群有 86 名患者,他们的年龄、性别和体重指数均与对照组相匹配。一名受过研究员培训的肌肉骨骼放射科医生重新评估了策划的图像,确定了前交叉韧带的状态。两名训练有素的医科学生独立收集临床数据,并在盲法X光片上测量斜率。使用 SPSS 统计软件包进行 ICC、Cohen's kappa 和病例对照匹配,并使用 ICC 和方差分析进行比较:结果:在 172 位接受过 172 次核磁共振成像检查和 X 光片检查的患者中,有 86 位对照组患者和 86 位前交叉韧带病变患者。男性为 108/172(62.79%),女性为 64/172(37.21%)。MTS的ICC值为0.966,LTS的ICC值为0.975,CTS的ICC值为0.978。类粘液变性患者的体重指数(BMI)比对照组高,年龄比对照组大(p 结论:各种 TS 测量结果都是可靠的:各种 TS 测量值都是可靠的。与正常前交叉韧带相比,LTS-MTS差异与不同的前交叉韧带病变有关。
{"title":"Association of tibial slope alterations with anterior cruciate ligament (ACL) injury and mucoid degeneration.","authors":"Varun Ravi, Mahad Rehman, Shuda Xia, Avneesh Chhabra, Flavio Duarte Silva","doi":"10.1007/s00256-024-04744-x","DOIUrl":"10.1007/s00256-024-04744-x","url":null,"abstract":"<p><strong>Objective: </strong>To compare radiographic measurements of lateral tibial slope (LTS), medial TS (MTS), and coronal TS (CTS) in MRI-defined intact, injured, and mucoid-degenerated native ACL knees and determine inter-reader reliability.</p><p><strong>Materials and methods: </strong>Patient records from 2 years at tertiary care hospitals were reviewed for individuals aged 18-100 undergoing 3-Tesla knee MRI and radiographs. Two randomly selected cohorts, control, and pathologic ACLs on MRI with 86 patients each, were age, gender, and BMI-matched. A fellowship-trained musculoskeletal radiologist reevaluated curated images, characterizing ACL status. Two trained medical students independently collected clinical data and measured slopes on blinded radiographs. ICC, Cohen's kappa, and case-control matching were performed using SPSS statistical package, with ICC and ANOVA used for comparisons.</p><p><strong>Results: </strong>Among 172 patients with 172 MRIs and radiographs, there were 86 controls and 86 ACL lesions. There were 108/172 (62.79%) males and 64/172 (37.21%) females. ICCs were 0.966 for MTS, 0.975 for LTS, and 0.978 for CTS. Mucoid degeneration patients had a higher BMI and were older than control (p < .05) or completely torn (p < .001) ACL patients. There was no difference in TS between normal and pathologic ACLs; however, LTS-MTS differences were larger with partial tears (2.5 ± 4.9) than normal ACLs by 4.5° (± 1.2, p < .001), complete tears by 4.5° (± 1.3, p < .001), and mucoid degeneration by 4.9° (± 1.5, p = .001).</p><p><strong>Conclusion: </strong>Various TS measurements are reliable. LTS-MTS differences are associated with different ACL lesions compared to normal ACLs.</p>","PeriodicalId":21783,"journal":{"name":"Skeletal Radiology","volume":" ","pages":"325-334"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141627611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combining morphological and functional imaging parameters to diagnose primary bone neoplasms in the skull base, spine and sacrum. 结合形态学和功能成像参数诊断颅底、脊柱和骶骨的原发性骨肿瘤。
IF 1.9 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-02-01 Epub Date: 2024-07-05 DOI: 10.1007/s00256-024-04742-z
Vesna Miladinovic, Augustinus D G Krol, Johan L Bloem, Judith V M G Bovée, Suk Wai Lam, Wilco C Peul, Ana Navas Cañete, Berit M Verbist

Purpose: Morphological magnetic resonance (MR) and computed tomography (CT) features are used in combination with histology for diagnosis and treatment selection of primary bone neoplasms. Isolated functional MRI parameters have shown potential in diagnosis. Our goal is to facilitate diagnosis of primary bone neoplasms of the skull base, mobile spine and sacrum, by a comprehensive approach, combining morphological and functional imaging parameters.

Materials and methods: Pre-treatment MR of 80 patients with histologically proven diagnosis of a primary bone neoplasm of the skull base, mobile spine and sacrum were retrospectively analyzed for morphological and functional MRI parameters. Functional parameters were measured in 4 circular regions of interest per tumor placed on non-adjacent scan slices. Differences in values of functional parameters between different histologies were analyzed with Dunn's test.

Results: Chordomas were the predominant histology (60.0%). Most neoplasms (80.0%) originated in the midline and had geographical (78.2%) bone destruction. Amorphous-type calcification (pre-existing bone) was seen only in chordomas. Homogeneous contrast enhancement pattern was seen only in chondrosarcoma and plasmacytoma. Ktrans and Kep were significantly lower in both chordoma, and chondrosarcoma compared to giant cell tumor of the bone (p = 0.006 - 0.011), and plasmacytoma (p = 0.004 - 0.014). Highest diffusion-weighted MRI apparent diffusion coefficient (ADC) values corresponded to chondrosarcoma and were significantly higher to those of chordoma (p = 0.008).

Conclusion: We identified the most discriminating morphological parameters and added functional MR parameters based on histopathological features that are useful in making a confident diagnosis of primary bone neoplasms in the skull base, mobile spine and sacrum.

目的:形态学磁共振(MR)和计算机断层扫描(CT)特征与组织学相结合,用于原发性骨肿瘤的诊断和治疗选择。单独的功能性磁共振成像参数已显示出诊断的潜力。我们的目标是通过结合形态学和功能成像参数的综合方法,帮助诊断颅底、活动脊柱和骶骨的原发性骨肿瘤:对80例经组织学证实诊断为颅底、活动脊柱和骶骨原发性骨肿瘤的患者进行治疗前磁共振成像形态学和功能学参数的回顾性分析。在非相邻扫描切片上的每个肿瘤的 4 个圆形感兴趣区测量功能参数。不同组织学之间功能参数值的差异用邓恩检验进行分析:结果:脊索瘤是主要的组织学类型(60.0%)。大多数肿瘤(80.0%)起源于中线,有地域性骨质破坏(78.2%)。无定形钙化(原有骨质)仅见于脊索瘤。均匀对比增强模式仅见于软骨肉瘤和浆细胞瘤。与骨巨细胞瘤(p = 0.006 - 0.011)和浆细胞瘤(p = 0.004 - 0.014)相比,脊索瘤和软骨肉瘤的 Ktrans 和 Kep 均明显较低。软骨肉瘤的弥散加权磁共振成像表观弥散系数(ADC)值最高,明显高于脊索瘤(p = 0.008):我们确定了最具鉴别力的形态学参数,并根据组织病理学特征增加了功能性 MR 参数,这些参数有助于对颅底、活动脊柱和骶骨的原发性骨肿瘤做出可靠诊断。
{"title":"Combining morphological and functional imaging parameters to diagnose primary bone neoplasms in the skull base, spine and sacrum.","authors":"Vesna Miladinovic, Augustinus D G Krol, Johan L Bloem, Judith V M G Bovée, Suk Wai Lam, Wilco C Peul, Ana Navas Cañete, Berit M Verbist","doi":"10.1007/s00256-024-04742-z","DOIUrl":"10.1007/s00256-024-04742-z","url":null,"abstract":"<p><strong>Purpose: </strong>Morphological magnetic resonance (MR) and computed tomography (CT) features are used in combination with histology for diagnosis and treatment selection of primary bone neoplasms. Isolated functional MRI parameters have shown potential in diagnosis. Our goal is to facilitate diagnosis of primary bone neoplasms of the skull base, mobile spine and sacrum, by a comprehensive approach, combining morphological and functional imaging parameters.</p><p><strong>Materials and methods: </strong>Pre-treatment MR of 80 patients with histologically proven diagnosis of a primary bone neoplasm of the skull base, mobile spine and sacrum were retrospectively analyzed for morphological and functional MRI parameters. Functional parameters were measured in 4 circular regions of interest per tumor placed on non-adjacent scan slices. Differences in values of functional parameters between different histologies were analyzed with Dunn's test.</p><p><strong>Results: </strong>Chordomas were the predominant histology (60.0%). Most neoplasms (80.0%) originated in the midline and had geographical (78.2%) bone destruction. Amorphous-type calcification (pre-existing bone) was seen only in chordomas. Homogeneous contrast enhancement pattern was seen only in chondrosarcoma and plasmacytoma. Ktrans and Kep were significantly lower in both chordoma, and chondrosarcoma compared to giant cell tumor of the bone (p = 0.006 - 0.011), and plasmacytoma (p = 0.004 - 0.014). Highest diffusion-weighted MRI apparent diffusion coefficient (ADC) values corresponded to chondrosarcoma and were significantly higher to those of chordoma (p = 0.008).</p><p><strong>Conclusion: </strong>We identified the most discriminating morphological parameters and added functional MR parameters based on histopathological features that are useful in making a confident diagnosis of primary bone neoplasms in the skull base, mobile spine and sacrum.</p>","PeriodicalId":21783,"journal":{"name":"Skeletal Radiology","volume":" ","pages":"287-302"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141535263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiomics based on multiple machine learning methods for diagnosing early bone metastases not visible on CT images. 基于多种机器学习方法的放射组学诊断 CT 图像上不可见的早期骨转移。
IF 1.9 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-02-01 Epub Date: 2024-07-19 DOI: 10.1007/s00256-024-04752-x
Huili Wang, Jianfeng Qiu, Weizhao Lu, Jindong Xie, Junchi Ma

Objectives: This study utilizes [99mTc]-methylene diphosphate (MDP) single photon emission computed tomography (SPECT) images as a reference standard to evaluate whether the integration of radiomics features from computed tomography (CT) and machine learning algorithms can identify microscopic early bone metastases. Additionally, we also determine the optimal machine learning approach.

Materials and methods: We retrospectively studied 63 patients with early bone metastasis from July 2020 to March 2023. The ITK-SNAP software was used to delineate early bone metastases and normal bone tissue in SPECT images of each patient, which were then registered onto CT images to outline the volume of interest (VOI). The VOI includes 63 early bone metastasis volumes and 63 normal bone tissue volumes. 126 VOIs were randomly distributed in a 7:3 ratio between the training and testing groups, and 944 radiomics features were extracted from every VOI. We established 20 machine learning models using 5 feature selection algorithms and 4 classification methods. Evaluate the performance of the model using the area under the receiver operating characteristic curve (AUC).

Results: Most machine learning models demonstrated outstanding discriminative capacity, with AUCs higher than 0.70. Notably, the K-Nearest Neighbors (KNN) classifier exhibited significant performance improvement compared to the other four classifiers. Specifically, the model constructed utilizing eXtreme Gradient Boosting (XGBoost) feature selection method integrated with KNN classifier achieved the maximum AUC, which is 0.989 in the training set and 0.975 in the testing set.

Conclusions: Radiomics features integrated with machine learning methods can identify early bone metastases that are not visible on CT images. In our analysis, KNN is considered the optimal classification method.

研究目的本研究利用[99mTc]-亚甲基二磷酸(MDP)单光子发射计算机断层扫描(SPECT)图像作为参考标准,评估计算机断层扫描(CT)的放射组学特征与机器学习算法的整合能否识别微小的早期骨转移。此外,我们还确定了最佳的机器学习方法:我们回顾性研究了 2020 年 7 月至 2023 年 3 月期间的 63 例早期骨转移患者。我们使用 ITK-SNAP 软件在每位患者的 SPECT 图像中划分出早期骨转移灶和正常骨组织,然后将这些图像登记到 CT 图像上,勾勒出感兴趣体(VOI)。VOI 包括 63 个早期骨转移灶体积和 63 个正常骨组织体积。126 个 VOI 按 7:3 的比例随机分配给训练组和测试组,并从每个 VOI 中提取了 944 个放射组学特征。我们使用 5 种特征选择算法和 4 种分类方法建立了 20 个机器学习模型。使用接收者操作特征曲线下面积(AUC)评估模型的性能:结果:大多数机器学习模型都表现出了出色的判别能力,AUC 均高于 0.70。值得注意的是,与其他四种分类器相比,K-近邻(KNN)分类器的性能有了显著提高。具体来说,利用极限梯度提升(XGBoost)特征选择方法与 KNN 分类器集成构建的模型达到了最大的 AUC,在训练集上为 0.989,在测试集上为 0.975:结合机器学习方法的放射组学特征可以识别 CT 图像上不可见的早期骨转移。在我们的分析中,KNN 被认为是最佳的分类方法。
{"title":"Radiomics based on multiple machine learning methods for diagnosing early bone metastases not visible on CT images.","authors":"Huili Wang, Jianfeng Qiu, Weizhao Lu, Jindong Xie, Junchi Ma","doi":"10.1007/s00256-024-04752-x","DOIUrl":"10.1007/s00256-024-04752-x","url":null,"abstract":"<p><strong>Objectives: </strong>This study utilizes [<sup>99m</sup>Tc]-methylene diphosphate (MDP) single photon emission computed tomography (SPECT) images as a reference standard to evaluate whether the integration of radiomics features from computed tomography (CT) and machine learning algorithms can identify microscopic early bone metastases. Additionally, we also determine the optimal machine learning approach.</p><p><strong>Materials and methods: </strong>We retrospectively studied 63 patients with early bone metastasis from July 2020 to March 2023. The ITK-SNAP software was used to delineate early bone metastases and normal bone tissue in SPECT images of each patient, which were then registered onto CT images to outline the volume of interest (VOI). The VOI includes 63 early bone metastasis volumes and 63 normal bone tissue volumes. 126 VOIs were randomly distributed in a 7:3 ratio between the training and testing groups, and 944 radiomics features were extracted from every VOI. We established 20 machine learning models using 5 feature selection algorithms and 4 classification methods. Evaluate the performance of the model using the area under the receiver operating characteristic curve (AUC).</p><p><strong>Results: </strong>Most machine learning models demonstrated outstanding discriminative capacity, with AUCs higher than 0.70. Notably, the K-Nearest Neighbors (KNN) classifier exhibited significant performance improvement compared to the other four classifiers. Specifically, the model constructed utilizing eXtreme Gradient Boosting (XGBoost) feature selection method integrated with KNN classifier achieved the maximum AUC, which is 0.989 in the training set and 0.975 in the testing set.</p><p><strong>Conclusions: </strong>Radiomics features integrated with machine learning methods can identify early bone metastases that are not visible on CT images. In our analysis, KNN is considered the optimal classification method.</p>","PeriodicalId":21783,"journal":{"name":"Skeletal Radiology","volume":" ","pages":"335-343"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Skeletal Radiology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1