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Corrigendum to “Long COVID as a risk factor for hypersomnolence and fatigue: insights from the 2nd International Covid Sleep Study Collaboration (ICOSS-2)” [Sleep Med. 136 (2025) 106764] “长冠状病毒是嗜睡和疲劳的风险因素:来自第二届国际冠状病毒睡眠研究合作(ICOSS-2)的见解”的勘误表[睡眠医学]. 136 (2025)106764]
IF 3.4 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-01-31 DOI: 10.1016/j.sleep.2026.108798
Tomi Sarkanen , Ilona Merikanto , Bjørn Bjorvatn , Frances Chung , Brigitte Holzinger , Charles M. Morin , Thomas Penzel , Luigi De Gennaro , Yun Kwok Wing , Christian Benedict , Pei Xue , Catia Reis , Maria Korman , Anne-Marie Landtblom , Kentaro Matsui , Harald Hrubos-Strøm , Sérgio Mota-Rolim , Michael R. Nadorff , Linor Berezin , Yaping Liu , Yves Dauvilliers
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引用次数: 0
Insomnia-LCA classifier: an open web application for insomnia subtype classification using latent class analysis 失眠- lca分类器:一个使用潜在类分析进行失眠亚型分类的开放web应用程序
IF 3.4 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-01-30 DOI: 10.1016/j.sleep.2026.108813
Matteo Carpi , Daniel Ruivo Marques
The heterogeneity of insomnia presentations has long challenged research and clinical practice, motivating efforts to identify reliable disorder phenotypes. Person-centered, data-driven approaches such as latent class analysis (LCA) have provided new insights, suggesting that insomnia subtypes may differ not only in nocturnal symptoms but also in perceived impact and daytime distress. Despite this progress, LCA solutions often remain confined to the original datasets, limiting replication and applied use.
To address this gap, we developed the insomnia-LCA classifier, an open-source web application that assigns new Insomnia Severity Index (ISI) response profiles to one of four subtypes identified in a previously published LCA of Italian university students: no insomnia (NI), subthreshold insomnia (SI), high insomnia risk (HI), and predominant daytime symptoms (DS). Using the original model's class priors and item-level conditional response probabilities, the app computes posterior class probabilities from user-entered ISI responses, individually or in batch mode. Outputs include class probabilities and modal assignment, ISI total and subscale scores, and a visual comparison between the individual profile and subtype mean patterns.
Reclassification of the original dataset showed near-perfect agreement with the latent class model (accuracy = 0.999; Cohen's kappa = 0.999), and synthetic profiles behaved as expected. The insomnia-LCA classifier provides a practical, reproducible tool for deploying and testing LCA-derived phenotypes in clinical research.
失眠表现的异质性长期以来一直挑战着研究和临床实践,促使人们努力确定可靠的疾病表型。以人为中心、数据驱动的方法,如潜在分类分析(LCA),提供了新的见解,表明失眠亚型可能不仅在夜间症状上不同,而且在感知影响和白天痛苦上也不同。尽管取得了这些进展,但LCA解决方案通常仍然局限于原始数据集,限制了复制和应用。为了解决这一差距,我们开发了失眠-LCA分类器,这是一个开源的网络应用程序,它将新的失眠严重指数(ISI)反应配置文件分配给先前发表的意大利大学生LCA中确定的四种亚型之一:无失眠(NI),亚阈值失眠(SI),高失眠风险(HI)和主要白天症状(DS)。使用原始模型的类先验和项目级条件反应概率,应用程序从用户输入的ISI响应中计算后验类概率,单独或批量模式。输出包括类概率和模态分配,ISI总分和子量表分数,以及个人概况和子类型平均模式之间的视觉比较。原始数据集的重新分类显示与潜在类别模型几乎完全一致(准确率= 0.999;Cohen's kappa = 0.999),合成剖面的表现与预期一致。失眠- lca分类器为临床研究中部署和测试lca衍生表型提供了一个实用的,可重复的工具。
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引用次数: 0
Effect of melatonin enriched with L-Tryptophan and 5-Hydroxytryptophan on sleep parameters in children with neurodevelopmental disorders. 富含l -色氨酸和5-羟色氨酸的褪黑素对神经发育障碍儿童睡眠参数的影响。
IF 3.4 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-01-30 DOI: 10.1016/j.sleep.2026.108818
Francy Cruz-Sanabria, Giovanni Cenerini, Simone Bruno, Raffaele Ferri, Simona Fiori, Ugo Faraguna

Introduction: Melatonin plays a key role in sleep regulation. Combining melatonin with its precursors, L-tryptophan (LT) and 5-Hydroxytryptophan (5HTP), may influence sleep-related outcomes, but evidence in children with neurodevelopmental disorders (NDDs) is limited. This exploratory study compares the effects of melatonin combined with 5HTP (M-5HTP) and melatonin combined with LT (M-LT) on sleep disorders in children with NDDs.

Methods: This single-center, randomized pilot comparative trial involved children under five years of age with NDDs free of sleep-inducing drugs. Baseline evaluations and actigraphy monitoring were performed. Children were randomly assigned to either M-5HTP (1 mg Melatonin +10 mg 5HTP) or M-LT (1 mg Melatonin +20 mg LT) treatment at 8 p.m. for at least four weeks. Post-treatment actigraphy monitoring assessed sleep parameters.

Results: Of 51 screened children, 26 were enrolled and 13 completed the study (M-5HTP: 9, M-LT: 4). No statistically significant between-group differences in change scores were observed. Within-group analyses showed a significant reduction in the Sleep Movement Index (SMI) from baseline to follow-up in the M-5HTP group (T0: 6.55; T1: 1.25; p=0.006), whereas no significant changes were observed in the M-LT group.

Discussion: In this exploratory pilot study, a within-group reduction in nocturnal motor activity was observed among M-5HTP completers. Given the small sample size, high attrition rate, and limited statistical power, these findings should be interpreted cautiously and considered hypothesis-generating.

褪黑素在睡眠调节中起着关键作用。将褪黑素与其前体l -色氨酸(LT)和5-羟色氨酸(5HTP)联合使用可能会影响睡眠相关的结果,但在患有神经发育障碍(ndd)的儿童中,证据有限。本探索性研究比较褪黑素联合5HTP (M-5HTP)与褪黑素联合LT (M-LT)对ndd患儿睡眠障碍的影响。方法:这项单中心、随机对照试验纳入了5岁以下无睡眠诱导药物的ndd患儿。进行基线评估和活动监测。儿童被随机分配到M-5HTP (1mg褪黑素+ 10mg 5HTP)或M-LT (1mg褪黑素+ 20mg LT)治疗,时间为晚上8点,持续至少四周。治疗后活动描记监测评估睡眠参数。结果:51名筛查儿童中,26名入组,13名完成研究(M-5HTP: 9, M-LT: 4)。组间变化评分差异无统计学意义。组内分析显示,M-5HTP组从基线到随访期间睡眠运动指数(SMI)显著降低(T0: 6.55; T1: 1.25; p=0.006),而M-LT组未观察到显著变化。讨论:在这项探索性的初步研究中,在M-5HTP完成者中观察到组内夜间运动活动的减少。考虑到样本量小,流失率高,统计能力有限,这些发现应该谨慎解释,并考虑假设生成。
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引用次数: 0
Effect of sex hormones on sleep architecture in older women 性激素对老年妇女睡眠结构的影响
IF 3.4 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-01-29 DOI: 10.1016/j.sleep.2025.106915
M. Varma
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引用次数: 0
Trait-Like Slow-Wave Activities Link to Cognition: Multi-Night At-Home Wireless EEG Study in Older Adults 特征样慢波活动与认知相关:老年人在家多夜无线脑电图研究
IF 3.4 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-01-29 DOI: 10.1016/j.sleep.2025.106935
S. Qin , J.L. Ong , K.F. Wong , T. Liang , E.K.K. Ng , W.-P. Koh , J.H. Zhou , M.W.L. Chee
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引用次数: 0
A Bistable Stochastic Model Quantifies Performance Degradation And Individual Vulnerability To Sleep Deprivation 双稳态随机模型量化性能退化和个体脆弱性睡眠剥夺
IF 3.4 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-01-29 DOI: 10.1016/j.sleep.2025.106937
S. Raison , P. Sanz-Leon , C. Schmidt , V. Muto , S. Postnova
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引用次数: 0
Chronic Intermittent hypoxia exacerbates the progress of periodontal disease via promoting inflammatory and microbial dysbiosis 慢性间歇性缺氧通过促进炎症和微生物生态失调而加剧牙周病的进展
IF 3.4 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-01-29 DOI: 10.1016/j.sleep.2025.106958
X. Wang , H. Chen , P. van der Stelt , S. Ge
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引用次数: 0
Enlarged perivascular spaces is associated with cognitive impairment in older adults with obstructive sleep apnoea 老年阻塞性睡眠呼吸暂停患者血管周围空间增大与认知障碍相关
IF 3.4 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-01-29 DOI: 10.1016/j.sleep.2025.106917
S. Kong , B. Sinclair , N. Espinosa , A. Lam , V. Vidal , M. Law , S. Naismith
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引用次数: 0
Benzodiazepine Burden and associated Health Risks in geriatric Patients with Hearing impairment: A Population-Based Cohort Study 老年听力障碍患者苯二氮卓类药物负担及相关健康风险:一项基于人群的队列研究
IF 3.4 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-01-29 DOI: 10.1016/j.sleep.2025.106910
H. Choi , H. Song , J.-H. Nam , J.-Y. Shin , J.-H. Seo , W.S. Jeong
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引用次数: 0
Lights Out, Waste Out: Dynamic Changes in Slow Wave Sleep Drive Peripheral Clearance of AD Biomarkers in Older Adults 熄灯,浪费:老年人慢波睡眠的动态变化驱动AD生物标志物的外周清除
IF 3.4 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-01-29 DOI: 10.1016/j.sleep.2025.106920
C. Diep , J.E. Manousakis , S.A. Miles , E. Hodgman , P. Maruff , M. Dresler , C. Anderson
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引用次数: 0
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Sleep medicine
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