Sleep medicine最新文献_第7页

A reliability generalization meta-analysis of the internal consistency and test-retest reliability of the pre-sleep arousal scale (PSAS) 睡眠前觉醒量表（PSAS）内部一致性和重测信度的信度概化元分析。

IF 3.8 2区医学 Q1 CLINICAL NEUROLOGY

Sleep medicine

Pub Date : 2025-02-01 DOI: 10.1016/j.sleep.2024.12.030

Inês Luana Correia , Waqar Husain , Maria Teresa Gonçalves , Luís Pires , Khaled Trabelsi , Ammar Achraf , Seithikurippu R. Pandi-Perumal , Perry M. Nicassio , Markus Jansson-Fröjmark , Michael V. Vitiello , Daniel Ruivo Marques , Haitham Jahrami

Purpose

The Pre-Sleep Arousal Scale (PSAS) is a self-report tool for assessing cognitive and somatic arousal before sleep. While the English version is well-validated, research on translations is limited. This meta-analysis examines PSAS translations’ internal consistency and reliability.

Methods

We conducted a comprehensive literature search using multiple databases to identify studies that reported the reliability of the PSAS. We used a random-effects meta-analysis model to pool estimates of internal consistency and test-retest reliability and explored potential moderators using subgroup analyses and meta-regression. To ensure transparency, we registered the study protocol, utilized the PRISMA checklist, and made all study code and data available on the Open Science Framework.

Results

Systematic review yielded a total 27 studies (reported in 25 publications) with 9354 participants employing eleven language versions of the PSAS. Meta-analysis showed good internal consistency for the total PSAS (0.88, 95%CI 0.86–0.90) as well as the cognitive (α = 0.89, 95%CI 0.88–0.90) and somatic (α = 0.80, 95%CI 0.77–0.83) subscales. The PSAS also displayed excellent test-retest reliability for the total scale (r = 0.87, 95%CI 0.84–0.90), cognitive subscale (α = 0.80, 95%CI 0.77–0.84) and somatic subscale (α = 0.70, 95%CI 0.67–0.74). Participant characteristics (age and sex) did not significantly affect results.

Conclusions

This meta-analysis shows that the PSAS is a reliable tool for detecting pre-sleep arousal based on its high internal consistency and test-retest reliability. The PSAS is useful across languages but quality translation appears to be crucial. Recommendations are offered for future adaptations and clinical use.

目的：睡眠前觉醒量表（PSAS）是一种评估睡眠前认知和躯体觉醒的自我报告工具。虽然英文版本得到了很好的验证，但对翻译的研究却很有限。本荟萃分析检验了PSAS翻译的内部一致性和可靠性。方法：我们使用多个数据库进行了全面的文献检索，以确定报道PSAS可靠性的研究。我们使用随机效应荟萃分析模型来汇总内部一致性和重测信度的估计，并使用亚组分析和荟萃回归来探索潜在的调节因素。为了确保透明度，我们注册了研究方案，使用了PRISMA检查表，并在开放科学框架上提供了所有研究代码和数据。结果：系统回顾共产生27项研究（在25篇出版物中报道），9354名参与者使用11种语言版本的PSAS。meta分析显示，总体PSAS量表（0.88,95%CI 0.86-0.90）、认知量表（α = 0.89, 95%CI 0.88-0.90）和躯体量表（α = 0.80, 95%CI 0.77-0.83）具有良好的内部一致性。PSAS在总量表（r = 0.87, 95%CI 0.84-0.90）、认知量表（α = 0.80, 95%CI 0.77-0.84）和躯体量表（α = 0.70, 95%CI 0.67-0.74）的重测信度也很好。参与者的特征（年龄和性别）对结果没有显著影响。结论：本荟萃分析显示PSAS具有较高的内部一致性和重测信度，是一种可靠的检测睡眠前觉醒的工具。PSAS在各种语言中都很有用，但高质量的翻译似乎至关重要。对今后的适应和临床应用提出了建议。

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引用次数: 0

Assessment of sleep quality using cardiopulmonary coupling and its predictive value for delirium in ICU patients 心肺耦合评价ICU患者睡眠质量及其对谵妄的预测价值。

IF 3.8 2区医学 Q1 CLINICAL NEUROLOGY

Sleep medicine

Pub Date : 2025-02-01 DOI: 10.1016/j.sleep.2024.12.020

Chunyan Liu, Xiaowei Ji, Jianhong Lu, Lei Zhong, Jie Hu, Yongbin Wang, Qing Zhou, Bo Xie

Objective

To assess sleep quality in intensive care unit (ICU) patients using cardiopulmonary coupling (CPC) analysis and explore its predictive value for delirium.

Method

ICU patients (n = 135) were divided into the delirium group (n = 44) and control group (n = 91) based on the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). CPC analysis was used to evaluate the sleep quality of all participants.

Result

Intergroup comparisons showed that total sleep time, stable sleep time, and sleep efficiency were significantly lower in the delirium group than in the control group, whereas unstable sleep time, rapid eye movement sleep time, wake-up time, stable sleep latency, and apnea-hypopnea index (AHI) were significantly higher in the delirium group than in the control group. Logistic regression analysis showed that advanced age and AHI were risk factors for delirium, whereas stable sleep time was a protective factor for delirium. Receiver operating characteristic (ROC) analysis showed that stable sleep time and stable sleep latency had a certain predictive value for delirium; the area under the ROC curve (AUC) for stable sleep time was higher (0.888 vs. 0.704). The cut-off value for stable sleep time was 0.65 h, with a sensitivity of 84.1 % and specificity of 81.3 %.

Conclusion

ICU patients with delirium have poorer sleep quality than patients without delirium. Stable sleep time derived from the CPC has a high predictive value for delirium and may serve as an objective indicator for its diagnosis.

目的：应用心肺耦合（CPC）分析评价重症监护病房（ICU）患者的睡眠质量，探讨其对谵妄的预测价值。方法：采用《重症监护病房（CAM-ICU）混淆评价方法》将135例ICU患者分为谵妄组（44例）和对照组（91例）。CPC分析用于评估所有参与者的睡眠质量。结果：组间比较显示，谵妄组总睡眠时间、稳定睡眠时间、睡眠效率显著低于对照组，而谵妄组不稳定睡眠时间、快速眼动睡眠时间、唤醒时间、稳定睡眠潜伏期、呼吸暂停低通气指数（AHI）显著高于对照组。Logistic回归分析显示高龄和AHI是谵妄的危险因素，而稳定的睡眠时间是谵妄的保护因素。受试者工作特征（ROC）分析显示稳定睡眠时间和稳定睡眠潜伏期对谵妄有一定的预测价值；稳定睡眠时间的ROC曲线下面积（AUC）较高（0.888比0.704）。稳定睡眠时间的临界值为0.65 h，敏感性为84.1%，特异性为81.3%。结论：ICU谵妄患者睡眠质量较非谵妄患者差。CPC稳定睡眠时间对谵妄有较高的预测价值，可作为谵妄诊断的客观指标。

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引用次数: 0

Sleep complaints in individuals with SYNGAP1-associated syndrome syngap1相关综合征患者的睡眠抱怨

IF 3.8 2区医学 Q1 CLINICAL NEUROLOGY

Sleep medicine

Pub Date : 2025-02-01 DOI: 10.1016/j.sleep.2024.12.026

Amanda Cristina Mosini , Mariana Moysés-Oliveira , Jessica Nayara Goes de Araujo , Pedro Guerreiro , Lais Cunha , Malú Zamariolli , Sandra Doria Xavier , Bianca Balbueno , Claudia Berlim de Mello , Gustavo Antonio Moreira , Monica L. Andersen , Sergio Tufik

Neurodevelopmental disorders pose significant clinical challenges related to atypical brain development, often manifesting as learning disabilities, developmental delays, intellectual deficits, behavioral issues, epilepsy, and sleep disturbances. Among genetic neuropsychiatric conditions, synaptopathies are notable for their impact on synaptic function, resulting in varied neuropsychiatric phenotypes. Among these, SYNGAP1-associated syndrome is characterized by intellectual disability, global developmental delay, autism, and epilepsy, primarily due to loss-of-function mutations. This study explored sleep behaviors in children with SYNGAP1-associated syndrome, using the Children's Sleep Habit Questionnaire and the Sleep Disturbance Scale for Children, comparing results with neurotypical controls matched for age and sex. The cohort included 23 individuals with confirmed SYNGAP1 mutations. Results indicated that 78.3 % of participants had epilepsy, often resistant to treatment. Neurodivergent individuals had significantly higher sleep disturbance scores than neurotypical peers, exhibiting increased bedtime resistance, longer sleep durations, and more frequent night awakenings. Additionally, neurodivergent children showed a greater need for parental presence to fall asleep and struggled with sleeping away from home. Neurodivergents' caregivers reported poor sleep quality, emphasizing the complex dynamics of caregiving in these situations. The study highlights the urgent need for targeted interventions to enhance sleep quality for affected children and their caregivers, underscoring the critical link between neurodevelopmental disorders and sleep disturbances.

神经发育障碍是与非典型大脑发育相关的重大临床挑战，通常表现为学习障碍、发育迟缓、智力缺陷、行为问题、癫痫和睡眠障碍。在遗传性神经精神疾病中，突触病以其对突触功能的影响而显着，导致不同的神经精神表型。其中，syngap1相关综合征以智力残疾、整体发育迟缓、自闭症和癫痫为特征，主要是由于功能突变丧失。本研究利用《儿童睡眠习惯问卷》和《儿童睡眠障碍量表》，探讨了syngap1相关综合征儿童的睡眠行为，并将结果与符合年龄和性别的神经正常对照组进行了比较。该队列包括23例已确认的SYNGAP1突变个体。结果显示78.3%的参与者患有癫痫，通常对治疗有抵抗性。神经发散性个体的睡眠障碍得分明显高于神经正常的同龄人，表现出更强的就寝阻力、更长的睡眠持续时间和更频繁的夜间醒来。此外，神经发散型儿童更需要父母的陪伴才能入睡，并且在远离家的地方难以入睡。神经分化者的护理人员报告睡眠质量差，强调了在这些情况下护理的复杂动态。该研究强调，迫切需要有针对性的干预措施，以提高受影响儿童及其照顾者的睡眠质量，强调神经发育障碍和睡眠障碍之间的关键联系。

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引用次数: 0

Long-term sleep irregularity is associated with elevated cumulative blood pressure in older adults: Evidence from a mobile health five-year longitudinal study

IF 3.8 2区医学 Q1 CLINICAL NEUROLOGY

Sleep medicine

Pub Date : 2025-01-31 DOI: 10.1016/j.sleep.2025.01.034

Han Xiao , Kexin Ding , Xiaoyi Li , Zechen Zhou , Yujia Ma , Xiaotong Dai , Yan Liu , Dafang Chen

Introduction

Sleep irregularity is increasingly recognized as a modifiable factor for cardiovascular health. This study aims to investigate relationships between short- and long-term sleep irregularity with blood pressure (BP) dynamics among older adults.

Methods

We used data from a prospective cohort involving community-dwelling older adults based on a mobile health (mHealth) app from 2018 to 2022. Short-term exposure was defined as sleep irregularity for one week. Cumulative sleep irregularity, calculated as the area under the curve over 12 months, was regarded as long-term exposure. Outcomes included short-term deviations in BP, longitudinal changes in BP, and cumulative BP over one year. Linear mixed models and generalized additive mixed models were conducted to investigate the associations between sleep irregularity and BP.

Results

A total of 1611 participants with a median age of 73.0 years were included. Short-term and long-term cumulative sleep irregularities were associated with increased SBP, DBP, and global BP Z-score. For instance, each SD increment in cumulative sleep onset timing SD was associated with a 0.42 mmHg increase in SBP (95 % CI, 0.25 to 0.60), a 0.31 mmHg increase in DBP (95 % CI, 0.17 to 0.45), respectively. Subgroup analyses indicated stronger associations among males and those with normotension. Strong linear dose-response relationships were further observed between cumulative sleep irregularity and cumulative BP.

Conclusions

Sleep irregularity, in both short-term and long-term exposure, is a risk factor for poor blood pressure control among older adults, highlighting the importance of implementing interventions promoting healthy sleep habits to mitigate cardiovascular risks.

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引用次数: 0

Clinical practice guidelines for switching or deprescribing hypnotic medications for chronic insomnia: Results of European neuropsychopharmacology and sleep expert's consensus group

IF 3.8 2区医学 Q1 CLINICAL NEUROLOGY

Sleep medicine

Pub Date : 2025-01-31 DOI: 10.1016/j.sleep.2025.01.033

Laura Palagini , Roberto Brugnoli , Bernardo M. Dell’ Osso , Marco Di Nicola , Giuseppe Maina , Giovanni Martinotti , Julia Maruani , Sibylle Mauries , Gianluca Serafini , Claudio Mencacci , Claudio Liguori , Luigi Ferini-Strambi , Pierre A. Geoffroy , Matteo Balestrieri

Introduction

Current guidelines recommend cognitive behavioural therapy for insomnia (CBT-I) as the first-line treatment for chronic insomnia. Pharmacological recommendations by European guidelines for the treatment of insomnia disorder include positive GABAergic modulators such as short and medium acting benzodiazepines and “Z-drugs” (eszopiclone, zaleplon, zolpidem, zopiclone), dual orexin receptor antagonists (DORAs; daridorexant), melatonin receptor agonists (melatonin 2 mg prolonged release - PR). Given the chronic nature of insomnia, the presence of non-responders to some treatments it is often necessary switching between various therapeutic approaches and medications. However, clear guidance regarding safe and effective protocols for switching these medications currently lacks in Europe.

Method

To address this gap, we used the RAND/UCLA Appropriateness to evaluate the appropriateness of procedures for switching medications prescribed for insomnia disorder. Following a systematic review of the literature conducted in accordance with the PRISMA guidelines, we then formulated some recommendations.

Results

Twenty-one papers were selected.

Conclusions

Discontinuation of Hypnotic Benzodiazepines and Z-drugs should be gradual, with dose reductions of 10–25 % each week. Multi-component CBT-I, daridorexant, eszopiclone, and melatonin 2 mg PR were shown to facilitate the gradual discontinuation of hypnotic benzodiazepines/Z-drugs within a cross-tapered program, which can be delayed when necessary. Finally, daridorexant and melatonin 2 mg PR do not require special switching or deprescribing protocols. Several sedative-hypnotic dosage reduction algorithms are proposed in this work for clinical use in real world settings.

{"title":"Clinical practice guidelines for switching or deprescribing hypnotic medications for chronic insomnia: Results of European neuropsychopharmacology and sleep expert's consensus group","authors":"Laura Palagini , Roberto Brugnoli , Bernardo M. Dell’ Osso , Marco Di Nicola , Giuseppe Maina , Giovanni Martinotti , Julia Maruani , Sibylle Mauries , Gianluca Serafini , Claudio Mencacci , Claudio Liguori , Luigi Ferini-Strambi , Pierre A. Geoffroy , Matteo Balestrieri","doi":"10.1016/j.sleep.2025.01.033","DOIUrl":"10.1016/j.sleep.2025.01.033","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Current g</em>uidelines recommend cognitive behavioural therapy for insomnia (CBT-I) as the first-line treatment for chronic insomnia. Pharmacological recommendations by European guidelines for the treatment of insomnia disorder include positive GABAergic modulators such as short and medium acting benzodiazepines and “Z-drugs” (eszopiclone, zaleplon, zolpidem, zopiclone), dual orexin receptor antagonists (DORAs; daridorexant), melatonin receptor agonists (melatonin 2 mg prolonged release - PR). Given the chronic nature of insomnia, the presence of non-responders to some treatments it is often necessary switching between various therapeutic approaches and medications. However, clear guidance regarding safe and effective protocols for switching these medications currently lacks in Europe.</div></div><div><h3>Method</h3><div>To address this gap, we used the RAND/UCLA Appropriateness to evaluate the appropriateness of procedures for switching medications prescribed for insomnia disorder. Following a systematic review of the literature conducted in accordance with the PRISMA guidelines, we then formulated some recommendations.</div></div><div><h3>Results</h3><div>Twenty-one papers were selected.</div></div><div><h3>Conclusions</h3><div>Discontinuation of Hypnotic Benzodiazepines and Z-drugs should be gradual, with dose reductions of 10–25 % each week. Multi-component CBT-I, daridorexant, eszopiclone, and melatonin 2 mg PR were shown to facilitate the gradual discontinuation of hypnotic benzodiazepines/Z-drugs within a cross-tapered program, which can be delayed when necessary. Finally, daridorexant and melatonin 2 mg PR do not require special switching or deprescribing protocols. Several sedative-hypnotic dosage reduction algorithms are proposed in this work for clinical use in real world settings.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"128 ","pages":"Pages 117-126"},"PeriodicalIF":3.8,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143350975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of chronotype, socioeconomic status, latitude, longitude, and seasonality on cognitive performance and academic outcomes in adolescents

IF 3.8 2区医学 Q1 CLINICAL NEUROLOGY

Sleep medicine

Pub Date : 2025-01-28 DOI: 10.1016/j.sleep.2025.01.030

Jennifer Burns , Amber R. Li , Kayla E. Rohr , Michael L. Thomas , Michael J. McCarthy , Alejandro D. Meruelo

Background

Adolescents' cognitive development and academic performance are influenced by sleep patterns, socioeconomic status (SES), and geographic factors. This study investigated how chronotype, social jetlag, weekday sleep duration, longitude, latitude, and SES impact cognitive outcomes and academic performance in a diverse adolescent sample.

Methods

Data from 3741 adolescents in a longitudinal study were analyzed. Cognitive outcomes were assessed using NIH Toolbox measures (vocabulary, attention, working memory, pattern recognition, and reading). Self-reported academic grades were included as an additional outcome. Sleep variables were derived from the Munich Chronotype Questionnaire. Linear mixed-effects models examined the relationships between predictors and outcomes, controlling for age, sex, SES, latitude, longitude, seasonality, and time of testing.

Results

Later chronotype and greater social jetlag were associated with poorer cognitive performance in vocabulary (β=−0.08, −0.18), working memory (β=−0.01, −0.09), and reading (β=−0.01, −0.17). Latitude showed small positive associations with vocabulary (β=0.09), attention (β=0.07), and working memory (β=0.07). In contrast, longitude showed negligible associations with cognitive and academic outcomes (∣β∣<0.05), suggesting limited geographic variability along this axis. Higher household income was associated with better performance in vocabulary (β=0.07) and reading (β=0.06), and better grades (β=−0.04). Males demonstrated better attention scores (β=0.11) but poorer pattern recognition (β=−0.20), along with lower academic performance compared to females (β=0.19). Academic grades were positively associated with chronotype (β=0.14) and social jetlag (β=0.07) but negatively with weekday sleep duration (β=−0.06). Seasonality showed no significant effects.

Conclusions

Chronotype, social jetlag, latitude, and SES are significant predictors of cognitive and academic outcomes in adolescents, while longitude showed minimal effects. These findings underscore the importance of circadian alignment and socioeconomic and geographic contexts in shaping adolescent development.

{"title":"The influence of chronotype, socioeconomic status, latitude, longitude, and seasonality on cognitive performance and academic outcomes in adolescents","authors":"Jennifer Burns , Amber R. Li , Kayla E. Rohr , Michael L. Thomas , Michael J. McCarthy , Alejandro D. Meruelo","doi":"10.1016/j.sleep.2025.01.030","DOIUrl":"10.1016/j.sleep.2025.01.030","url":null,"abstract":"<div><h3>Background</h3><div>Adolescents' cognitive development and academic performance are influenced by sleep patterns, socioeconomic status (SES), and geographic factors. This study investigated how chronotype, social jetlag, weekday sleep duration, longitude, latitude, and SES impact cognitive outcomes and academic performance in a diverse adolescent sample.</div></div><div><h3>Methods</h3><div>Data from 3741 adolescents in a longitudinal study were analyzed. Cognitive outcomes were assessed using NIH Toolbox measures (vocabulary, attention, working memory, pattern recognition, and reading). Self-reported academic grades were included as an additional outcome. Sleep variables were derived from the Munich Chronotype Questionnaire. Linear mixed-effects models examined the relationships between predictors and outcomes, controlling for age, sex, SES, latitude, longitude, seasonality, and time of testing.</div></div><div><h3>Results</h3><div>Later chronotype and greater social jetlag were associated with poorer cognitive performance in vocabulary (β=−0.08, −0.18), working memory (β=−0.01, −0.09), and reading (β=−0.01, −0.17). Latitude showed small positive associations with vocabulary (β=0.09), attention (β=0.07), and working memory (β=0.07). In contrast, longitude showed negligible associations with cognitive and academic outcomes (∣β∣<0.05), suggesting limited geographic variability along this axis. Higher household income was associated with better performance in vocabulary (β=0.07) and reading (β=0.06), and better grades (β=−0.04). Males demonstrated better attention scores (β=0.11) but poorer pattern recognition (β=−0.20), along with lower academic performance compared to females (β=0.19). Academic grades were positively associated with chronotype (β=0.14) and social jetlag (β=0.07) but negatively with weekday sleep duration (β=−0.06). Seasonality showed no significant effects.</div></div><div><h3>Conclusions</h3><div>Chronotype, social jetlag, latitude, and SES are significant predictors of cognitive and academic outcomes in adolescents, while longitude showed minimal effects. These findings underscore the importance of circadian alignment and socioeconomic and geographic contexts in shaping adolescent development.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"128 ","pages":"Pages 95-102"},"PeriodicalIF":3.8,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association of parental insomnia symptoms with adolescent insomnia and depressive symptoms: A child–parent dyad study

IF 3.8 2区医学 Q1 CLINICAL NEUROLOGY

Sleep medicine

Pub Date : 2025-01-28 DOI: 10.1016/j.sleep.2025.01.026

Meijiao Huang, Dongfang Wang, Yifan Zhang, Min Li, Huolian Li, Xiangting Zhang, Xuan Wang, Fang Fan

Intergenerational transmission may be present in adolescents' sleep and mental health problems, but there is limited evidence currently available. The current study aimed to examine the effects of parental insomnia symptoms on adolescent insomnia and depressive symptoms. From 21 April to May 12, 2021, this study conducted a large-scale cross-sectional survey in south China, 68,751 valid child-parent matched data were collected. The current study measured parental insomnia symptoms, adolescent insomnia symptoms, adolescent depressive symptoms, and demographic characteristics. SPSS 27 statistical software was used to perform Chi-square analysis, binary logistic regression, and indirect effect testing. In this sample, maternal and paternal insomnia has a prevalence of 8.2 % and 7.5 %. Among adolescents whose mother or father had insomnia, the prevalence of insomnia reached to 15.7 % and 15.1 %, and the prevalence of depressive symptoms reached to 17.6 % and 15.6 %. Adolescents whose parents have insomnia were more likely to suffer from insomnia and depressive symptoms. Moreover, parents' insomnia positively influences adolescent depressive symptoms through the mediation of the child's insomnia. This study prompts a reevaluation of family health dynamics in clinical practice and public health policy, leading to a more holistic approach to addressing adolescent sleep patterns and depressive symptoms.

{"title":"The association of parental insomnia symptoms with adolescent insomnia and depressive symptoms: A child–parent dyad study","authors":"Meijiao Huang, Dongfang Wang, Yifan Zhang, Min Li, Huolian Li, Xiangting Zhang, Xuan Wang, Fang Fan","doi":"10.1016/j.sleep.2025.01.026","DOIUrl":"10.1016/j.sleep.2025.01.026","url":null,"abstract":"<div><div>Intergenerational transmission may be present in adolescents' sleep and mental health problems, but there is limited evidence currently available. The current study aimed to examine the effects of parental insomnia symptoms on adolescent insomnia and depressive symptoms. From 21 April to May 12, 2021, this study conducted a large-scale cross-sectional survey in south China, 68,751 valid child-parent matched data were collected. The current study measured parental insomnia symptoms, adolescent insomnia symptoms, adolescent depressive symptoms, and demographic characteristics. SPSS 27 statistical software was used to perform Chi-square analysis, binary logistic regression, and indirect effect testing. In this sample, maternal and paternal insomnia has a prevalence of 8.2 % and 7.5 %. Among adolescents whose mother or father had insomnia, the prevalence of insomnia reached to 15.7 % and 15.1 %, and the prevalence of depressive symptoms reached to 17.6 % and 15.6 %. Adolescents whose parents have insomnia were more likely to suffer from insomnia and depressive symptoms. Moreover, parents' insomnia positively influences adolescent depressive symptoms through the mediation of the child's insomnia. This study prompts a reevaluation of family health dynamics in clinical practice and public health policy, leading to a more holistic approach to addressing adolescent sleep patterns and depressive symptoms.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"128 ","pages":"Pages 103-109"},"PeriodicalIF":3.8,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The up-regulation of PTBP1 expression level in patients with Insomnia by senile dementia and promote cuproptosis of nerve cell by SLC31A1

IF 3.8 2区医学 Q1 CLINICAL NEUROLOGY

Sleep medicine

Pub Date : 2025-01-28 DOI: 10.1016/j.sleep.2025.01.025

Jing Wang , Xiaoli Zhao , Bin Han , Kun Meng , Lan Gao

Alzheimer's disease (AD), often referred to as the modern-day scourge, stands as a significant health challenge characterized by high rates of disability and mortality, particularly among the geriatric population. Thus, the present study investigated the precise details of PTBP1 involvement in cuproptosis of nerve cell of patients with Insomnia by senile dementia (ISD). Patients with ISD, early mild cognitive impairment (EMCI) and Normal healthy volunteers were obtained.

In the context of ISD, the elevated PTBP1 mRNA expressions were observed in patient samples, correlating positively with diminished cognitive function as measured by the Mini-Mental State Examination (MMSE) and increased geriatric depression scale scores. The pivotal role of PTBP1 was further underscored by its inhibitory effects in a mice model, which prevented the development of senile dementia, and its influence on neuronal cell proliferation and ROS-induced oxidative stress in vitro. Additionally, PTBP1's regulatory capacity on the cuproptosis of nerve cells and its modulation of SLC31A1 expression, through effects on ubiquitination, were revealed. The stability of PTBP1, critical for its function, was enhanced by the m6A modification mediated by METTL3, highlighting a complex regulatory network in the pathogenesis of ISD.

These data confirmed that PTBP1 plays a pivotal role in promoting the oxidative response and cuproptosis in Alzheimer's disease models via the SLC31A1 pathway. The findings suggest that PTBP1 could serve as a potential biomarker for the diagnosis and prognostic evaluation of ISD and AD, paving the way for the development of novel therapeutic strategies targeting this protein.

{"title":"The up-regulation of PTBP1 expression level in patients with Insomnia by senile dementia and promote cuproptosis of nerve cell by SLC31A1","authors":"Jing Wang , Xiaoli Zhao , Bin Han , Kun Meng , Lan Gao","doi":"10.1016/j.sleep.2025.01.025","DOIUrl":"10.1016/j.sleep.2025.01.025","url":null,"abstract":"<div><div>Alzheimer's disease (AD), often referred to as the modern-day scourge, stands as a significant health challenge characterized by high rates of disability and mortality, particularly among the geriatric population. Thus, the present study investigated the precise details of PTBP1 involvement in cuproptosis of nerve cell of patients with Insomnia by senile dementia (ISD). Patients with ISD, early mild cognitive impairment (EMCI) and Normal healthy volunteers were obtained.</div><div>In the context of ISD, the elevated PTBP1 mRNA expressions were observed in patient samples, correlating positively with diminished cognitive function as measured by the Mini-Mental State Examination (MMSE) and increased geriatric depression scale scores. The pivotal role of PTBP1 was further underscored by its inhibitory effects in a mice model, which prevented the development of senile dementia, and its influence on neuronal cell proliferation and ROS-induced oxidative stress in vitro. Additionally, PTBP1's regulatory capacity on the cuproptosis of nerve cells and its modulation of SLC31A1 expression, through effects on ubiquitination, were revealed. The stability of PTBP1, critical for its function, was enhanced by the m6A modification mediated by METTL3, highlighting a complex regulatory network in the pathogenesis of ISD.</div><div>These data confirmed that PTBP1 plays a pivotal role in promoting the oxidative response and cuproptosis in Alzheimer's disease models via the SLC31A1 pathway. The findings suggest that PTBP1 could serve as a potential biomarker for the diagnosis and prognostic evaluation of ISD and AD, paving the way for the development of novel therapeutic strategies targeting this protein.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"128 ","pages":"Pages 206-218"},"PeriodicalIF":3.8,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nadir heart rate as a novel risk marker of postoperative complications - A propensity matched analysis

IF 3.8 2区医学 Q1 CLINICAL NEUROLOGY

Sleep medicine

Pub Date : 2025-01-27 DOI: 10.1016/j.sleep.2025.01.014

Jesper Mølgaard , Leon Mayer , Søren Straarup Rasmussen , Camilla Haahr-Raunkjær , Michael Patrick Achiam , Lars Nannestad Jørgensen , Christian Sylvest Meyhoff , Eske Kvanner Aasvang

Aim

Although vital signs have a well-described 24-h cyclic variation (circadian rhythm), this variation is often not considered in clinical vital sign monitoring despite being influenced by physiologic stress from complications. This study aimed to evaluate the lowest heart rate at night (night-nadir) (NN-HR) as a novel risk marker for serious adverse events (SAE) in postoperative patients, rather than the average nocturnal heart rate.

Methods

This was a propensity-matched nested case-control study of continuously monitored vital sign data (heart rate (HR), respiration rate, oxygen saturation and blood pressure) for up to 5 days after major non-cardiac surgery. The primary outcome was any SAE that occurred up to 24 h after a circadian value calculation. We compared NN-HR between patients who developed SAE and those who did not during similar postoperative periods.

Results

Out of 588 patients, 104 (17.8 %) experienced an SAE during the monitored period and were matched with a median of 201 controls. The NN-HR was significantly higher in patients with impending SAE (median 74.0 bpm [IQR 68.2–81.8] vs. 68.3 bpm [IQR 61.5–76.0], p < 0.001). An NN-HR threshold of >67 bpm identified patients at increased risk (risk ratio 2.43, 99 % CI 1.24–5.00) for SAE, however with only moderate predictive performance (F1 score 0.58).

Conclusion

Absence of HR below 67 bpm at night, was significantly associated with increased SAE risk, highlighting the potential value of NN-HR as a monitoring target.The potential clinical utility of monitoring NN-HR to prevent SAE warrants further prospective investigation.

{"title":"Nadir heart rate as a novel risk marker of postoperative complications - A propensity matched analysis","authors":"Jesper Mølgaard , Leon Mayer , Søren Straarup Rasmussen , Camilla Haahr-Raunkjær , Michael Patrick Achiam , Lars Nannestad Jørgensen , Christian Sylvest Meyhoff , Eske Kvanner Aasvang","doi":"10.1016/j.sleep.2025.01.014","DOIUrl":"10.1016/j.sleep.2025.01.014","url":null,"abstract":"<div><h3>Aim</h3><div>Although vital signs have a well-described 24-h cyclic variation (circadian rhythm), this variation is often not considered in clinical vital sign monitoring despite being influenced by physiologic stress from complications. This study aimed to evaluate the lowest heart rate at night (night-nadir) (NN-HR) as a novel risk marker for serious adverse events (SAE) in postoperative patients, rather than the average nocturnal heart rate.</div></div><div><h3>Methods</h3><div>This was a propensity-matched nested case-control study of continuously monitored vital sign data (heart rate (HR), respiration rate, oxygen saturation and blood pressure) for up to 5 days after major non-cardiac surgery. The primary outcome was any SAE that occurred up to 24 h after a circadian value calculation. We compared NN-HR between patients who developed SAE and those who did not during similar postoperative periods.</div></div><div><h3>Results</h3><div>Out of 588 patients, 104 (17.8 %) experienced an SAE during the monitored period and were matched with a median of 201 controls. The NN-HR was significantly higher in patients with impending SAE (median 74.0 bpm [IQR 68.2–81.8] vs. 68.3 bpm [IQR 61.5–76.0], p < 0.001). An NN-HR threshold of >67 bpm identified patients at increased risk (risk ratio 2.43, 99 % CI 1.24–5.00) for SAE, however with only moderate predictive performance (F1 score 0.58).</div></div><div><h3>Conclusion</h3><div>Absence of HR below 67 bpm at night, was significantly associated with increased SAE risk, highlighting the potential value of NN-HR as a monitoring target.The potential clinical utility of monitoring NN-HR to prevent SAE warrants further prospective investigation.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"128 ","pages":"Pages 65-73"},"PeriodicalIF":3.8,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of sleep disordered breathing with severity and control of persistent asthma in Indian children

IF 3.8 2区医学 Q1 CLINICAL NEUROLOGY

Sleep medicine

Pub Date : 2025-01-27 DOI: 10.1016/j.sleep.2025.01.032

Aarushi Singla , Jyoti Bagla , Dipti Gothi , Sweta Kumari , Anand Prakash Dubey

Objective

To assess the association of pediatric sleep disordered breathing (SDB) with control and severity of asthma, and to evaluate the comorbidities associated with both.

Methods

Based on the Sleep-Related Breathing Disorder scale, extracted from the Pediatric Sleep Questionnaire (SDBS-PSQ), children (5–15 years) with persistent asthma were classified as; with SDB (SDBS-PSQ≥0.33) and without SDB (SDBS-PSQ<0.33), in a cross-sectional study. Baseline characteristics were compared. Control of asthma into well-controlled, not-well, and poorly controlled was assessed using childhood – asthma control test (c-ACT). Comorbidities like adeno-tonsillar hypertrophy, gastroesophageal reflux disease (GERD), obesity and allergic rhinitis (AR) for presence of SDB in asthma were assessed.

Results

Sixty asthmatics were included. Mild, moderate, and severe persistent asthma was observed in 26.67 %, 40 % and 33.33 % respectively, with 18.33 % asthmatics having SDB. 42.3 % of uncontrolled asthmatics had SDB. Baseline characteristics were similar in both groups. Asthmatics with SDB had higher frequency of severe persistent (63.6 % vs 26.5 %, p = 0.018) and uncontrolled asthma i.e. partly & poorly controlled (100 % vs 30.6 %, p < 0.001) versus asthmatics without SDB. Mean SDBS-PSQ score was higher in uncontrolled asthmatics compared to well-controlled asthmatics (0.255 ± 0.19 vs 0.047 ± 0.06, p < 0.001). Mean c–ACT score was lower with SDB (14.45 ± 3.20 vs 20.04 ± 4.56, p < 0.001), indicating poor control of asthma. A negative relationship was established between c-ACT and SDBS-PSQ (p < 0.001, r² = −0.36). Higher occurrence of AR was found in asthmatics with SDB (72.7 % vs 20.4 %, p = 0.001).

Conclusion

SDB may be associated with poor control and worsening severity of asthma. Concomitant AR was found in asthmatic children with SDB.

{"title":"Association of sleep disordered breathing with severity and control of persistent asthma in Indian children","authors":"Aarushi Singla , Jyoti Bagla , Dipti Gothi , Sweta Kumari , Anand Prakash Dubey","doi":"10.1016/j.sleep.2025.01.032","DOIUrl":"10.1016/j.sleep.2025.01.032","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the association of pediatric sleep disordered breathing (SDB) with control and severity of asthma, and to evaluate the comorbidities associated with both.</div></div><div><h3>Methods</h3><div>Based on the Sleep-Related Breathing Disorder scale, extracted from the Pediatric Sleep Questionnaire (SDBS-PSQ), children (5–15 years) with persistent asthma were classified as; with SDB (SDBS-PSQ≥0.33) and without SDB (SDBS-PSQ<0.33), in a cross-sectional study. Baseline characteristics were compared. Control of asthma into well-controlled, not-well, and poorly controlled was assessed using childhood – asthma control test (c-ACT). Comorbidities like adeno-tonsillar hypertrophy, gastroesophageal reflux disease (GERD), obesity and allergic rhinitis (AR) for presence of SDB in asthma were assessed.</div></div><div><h3>Results</h3><div>Sixty asthmatics were included. Mild, moderate, and severe persistent asthma was observed in 26.67 %, 40 % and 33.33 % respectively, with 18.33 % asthmatics having SDB. 42.3 % of uncontrolled asthmatics had SDB. Baseline characteristics were similar in both groups. Asthmatics with SDB had higher frequency of severe persistent (63.6 % vs 26.5 %, p = 0.018) and uncontrolled asthma i.e. partly & poorly controlled (100 % vs 30.6 %, p < 0.001) versus asthmatics without SDB. Mean SDBS-PSQ score was higher in uncontrolled asthmatics compared to well-controlled asthmatics (0.255 ± 0.19 vs 0.047 ± 0.06, p < 0.001). Mean c–ACT score was lower with SDB (14.45 ± 3.20 vs 20.04 ± 4.56, p < 0.001), indicating poor control of asthma. A negative relationship was established between c-ACT and SDBS-PSQ (p < 0.001, r<sup>2</sup> = −0.36). Higher occurrence of AR was found in asthmatics with SDB (72.7 % vs 20.4 %, p = 0.001).</div></div><div><h3>Conclusion</h3><div>SDB may be associated with poor control and worsening severity of asthma. Concomitant AR was found in asthmatic children with SDB.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"128 ","pages":"Pages 82-88"},"PeriodicalIF":3.8,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0