Sleep medicine最新文献

{"title":"Hypersomnia and cataplexy in Moebius syndrome","authors":"Antonella Barbieri , Marco Veneruso , Lorenzo Chiarella , Lino Nobili , Ramona Cordani","doi":"10.1016/j.sleep.2024.10.012","DOIUrl":"10.1016/j.sleep.2024.10.012","url":null,"abstract":"","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 421-423"},"PeriodicalIF":3.8,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Sniff Nasal Inspiratory Pressure be a guide in detecting of sleep-disordered breathing in children with Duchenne Muscular Dystrophy?","authors":"Mine Yüksel Kalyoncu ,&nbsp;Yasemin Gokdemir ,&nbsp;Cansu Yilmaz Yegit ,&nbsp;Muruvvet Yanaz ,&nbsp;Aynur Gulieva ,&nbsp;Merve Selcuk ,&nbsp;Şeyda Karabulut ,&nbsp;Neval Metin Çakar ,&nbsp;Almala Pınar Ergenekon ,&nbsp;Yavuz Gündoğdu ,&nbsp;Meltem Sabancı ,&nbsp;Kadir Lale ,&nbsp;Ela Erdem Eralp ,&nbsp;Gülten Öztürk ,&nbsp;Olcay Ünver ,&nbsp;Ali Cemal Yumuşakhuylu ,&nbsp;Dilşad Türkdoğan ,&nbsp;Fazilet Karakoç ,&nbsp;Bulent Karadag","doi":"10.1016/j.sleep.2024.10.004","DOIUrl":"10.1016/j.sleep.2024.10.004","url":null,"abstract":"<div><h3>Purpose</h3><div>Duchenne muscular dystrophy (DMD) is a severe, progressive condition characterized by muscle degeneration and weakness, significantly affecting respiratory function. This study aimed to evaluate the presence of sleep-disordered breathing (SDB) in children with DMD and investigate the relationships between sleep and respiratory function using spirometry, sniff nasal inspiratory pressure (SNIP), and polysomnography (PSG) along with capnography.</div></div><div><h3>Research question</h3><div>Can low SNIP be a guide for detecting respiratory muscle involvement early and determining the right time to perform early PSG and capnography in DMD?</div></div><div><h3>Study design</h3><div>Prospective, observational, cross-sectional study.</div></div><div><h3>Methods</h3><div>This study included DMD patients aged &lt;18 years. Pulmonary function tests were conducted using spirometry and SNIP, and maximum inspiratory and expiratory pressure were measured. PSG and capnography were performed within two weeks after the pulmonary function tests, and their relationships with each other were investigated.</div></div><div><h3>Results</h3><div>The study included 44 children. Obstructive sleep apnea syndrome (OSAS) was present in 70.5 % of patients, while nocturnal hypoventilation was observed in 4.5 %. SNIP values were significantly lower in patients with moderate-to-severe OSAS than in those without OSAS. An SNIP value below 40 cm H2O was associated with a 92.8 % prevalence of OSAS.</div></div><div><h3>Conclusion</h3><div>SNIP is a valuable, noninvasive marker for the early detection of respiratory muscle involvement and SDB in patients with DMD. This study highlights the need for early and regular respiratory monitoring in children with DMD to enhance care and quality of life.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 662-668"},"PeriodicalIF":3.8,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delphi consensus recommendations for the management of chronic insomnia in Canada","authors":"Charles M. Morin ,&nbsp;Atul Khullar ,&nbsp;Rebecca Robillard ,&nbsp;Alex Desautels ,&nbsp;Michael S.B. Mak ,&nbsp;Thien Thanh Dang-Vu ,&nbsp;Walter Chow ,&nbsp;Jeff Habert ,&nbsp;Serge Lessard ,&nbsp;Lemore Alima ,&nbsp;Najib T. Ayas ,&nbsp;James MacFarlane ,&nbsp;Tetyana Kendzerska ,&nbsp;Elliott K. Lee ,&nbsp;Colleen E. Carney","doi":"10.1016/j.sleep.2024.09.038","DOIUrl":"10.1016/j.sleep.2024.09.038","url":null,"abstract":"<div><h3>Objective</h3><div>The lack of current Canadian practice guidelines for the management of insomnia poses a challenge for healthcare providers (HCP) in selecting the appropriate treatment options. This study aimed to establish expert consensus recommendations for the management of chronic insomnia in Canada.</div></div><div><h3>Composition of the committee</h3><div>Sixteen multidisciplinary experts in sleep medicine and insomnia across Canada developed consensus recommendations based on their knowledge of the literature and their practical experience.</div></div><div><h3>Methods</h3><div>The consensus recommendations were developed through a Delphi method. Consensus was reached if at least 75 % of the voting participants “agreed” or “strongly agreed” with the corresponding statements. The quality of supporting evidence was rated using a GRADE rating system.</div></div><div><h3>Report</h3><div>Among 37 recommendations that reached consensus for the management of chronic insomnia, the experts recommend and agree that.</div></div><div><h3>Conclusion</h3><div>These consensus recommendations highlight the need to increase awareness, capacity for, and access to CBT-I; integrate newly approved pharmacotherapy; reduce both self-medication and medications with limited evidence or low risk/benefit ratio.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 598-605"},"PeriodicalIF":3.8,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142553623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nightmares in the elderly: Associations with self-reported executive functions","authors":"Wesley J. Wildman ,&nbsp;Aidan David ,&nbsp;George Hodulik ,&nbsp;John Balch ,&nbsp;David Rohr ,&nbsp;Patrick McNamara","doi":"10.1016/j.sleep.2024.10.001","DOIUrl":"10.1016/j.sleep.2024.10.001","url":null,"abstract":"<div><h3>Study objectives</h3><div>To describe nightmare phenomenology among community dwelling elderly and to test the hypothesis that reduction in cognitive control is associated with nightmare-related phenomenology including nightmare frequency and severity, greater emotional reactivity, imagery immersion, and dream enactment behaviors (DEBs).</div></div><div><h3>Methods</h3><div>Study 1: Survey with multiple regression and ANOVAs on N = 56 people with frequent nightmares plus N = 62 age- and gender-matched controls to quantify the strength of the association between cognitive control variables and nightmare phenomenology. <strong>Study 2</strong>: Computational simulation of nightmare phenomenology in relation to cognitive control to simulate the empirical findings and to assess the underlying causal theory through computationally supported causal inference.</div></div><div><h3>Results</h3><div>Study 1: Regressions demonstrated a strong association between reduction in cognitive control and more extreme nightmare phenomenology, including severity, frequency, daytime effects, and DEBs. Study 2: The computational simulation of nightmare phenomenology in relation to cognitive control is validated relative to regressions from study 1 and offers computational support for the causal theory explaining the associations in study 1.</div></div><div><h3>Conclusions</h3><div>In aging people, decline in executive cognitive functions, cognitive control, and inhibitory processes reduce cognitive control over emotions, thus contributing to unusual nightmare activity, including more extreme nightmare phenomenology such as more severe nightmares, greater emotional reactivity, deeper imagery immersion, and DEBs.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 381-395"},"PeriodicalIF":3.8,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142401372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between grit and insomnia: A population-based study","authors":"Jae Rim Kim ,&nbsp;Jung-A Park ,&nbsp;Hong-Jik Kim ,&nbsp;Jee-Eun Yoon ,&nbsp;Dana Oh ,&nbsp;Hyo Jin Park ,&nbsp;Sang Min Paik ,&nbsp;Woo-Jin Lee ,&nbsp;Daeyoung Kim ,&nbsp;Kwang Ik Yang ,&nbsp;Min Kyung Chu ,&nbsp;Chang-Ho Yun","doi":"10.1016/j.sleep.2024.10.006","DOIUrl":"10.1016/j.sleep.2024.10.006","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to investigate the association of the grit scale, a personality trait characterized by perseverance and passion, with both the presence and the severity of insomnia in the Korean adult population.</div></div><div><h3>Methods</h3><div>A nationwide population-based cross-sectional survey was conducted through face-to-face interviews using structured questionnaires between September and December 2018 in Korea. Grit was assessed by using the 8-item Short Grit Scale. Participants were categorized into insomnia and non-insomnia groups based on a threshold of 10 on the Insomnia Severity Index (ISI). The association between girt and insomnia was analyzed using multiple linear regression and multivariable logistic regression, controlling for sociodemographic factors, lifestyles, and comorbidities.</div></div><div><h3>Results</h3><div>A total of 2453 participants (49.9 % male; aged 19–92 years) were enrolled in the study. Individual grit scores ranged from 1.75 to 5.00 points (mean [SD], 3.27 [0.42]), and insomnia was present in 16.5 % of the population. The insomnia group exhibited lower grit score compared to the non-insomnia group (3.11 [0.40] vs. 3.30 [0.42], <em>p</em> &lt; 0.001, Cohen's <em>d</em> = 0.46). Grit was negatively associated with ISI scores (β = −0.15, 95 % CI = −0.19, −0.11, <em>p</em> &lt; 0.001) and with having insomnia (OR 0.40, 95 % CI = 0.30, 0.55, <em>p</em> &lt; 0.001), after controlling for covariates.</div></div><div><h3>Conclusions</h3><div>Individuals with higher grit were less likely to have insomnia. Clinicians should consider personality traits, such as grit, in the evaluation and the management of insomnia.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 371-377"},"PeriodicalIF":3.8,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142393453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep quality and sleep duration are associated with charitable donations: Evidence from two population-based surveys","authors":"Allison E. Nickel,&nbsp;Michael K. Scullin","doi":"10.1016/j.sleep.2024.10.007","DOIUrl":"10.1016/j.sleep.2024.10.007","url":null,"abstract":"<div><h3>Study objectives</h3><div>Insufficient sleep alters emotional processing, leading to mood disturbances, reduced gratitude, and potentially the withdrawal of compassionate helping. Using data from two national surveys, we investigated whether sleep quality and sleep duration were associated with willingness to donate to local charities and places of worship.</div></div><div><h3>Methods</h3><div>We conducted secondary analyses of two Gallup-administered studies that used random address-based sampling methodologies to approximate population-representative samples. BRS-5 included 1501 respondents and BRS-6 included 1336 respondents (independent samples). Each survey inquired about sleep quality and whether participants had donated in the last year to local organizations and places of worship. In addition, BRS-5 included questions about sleep duration.</div></div><div><h3>Results</h3><div>In both studies, participants who had better sleep quality and better sleep durations were more likely to donate charitably to local organizations and places of worship (ORs of 1.07–1.45). Most associations remained significant when accounting for age, gender, and income.</div></div><div><h3>Conclusion</h3><div>Better sleep was associated with a greater likelihood to donate charitably. Experimental work is needed to determine if the relationship between sleep health and prosocial behaviors is uni- or bi-directional.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 378-380"},"PeriodicalIF":3.8,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142401373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidimensional phenotyping to distinguish among central (CSA), obstructive (OSA) and co-existing central and obstructive sleep apnea (CSA-OSA) phenotypes in real-world data","authors":"Jean-Louis Pépin ,&nbsp;Alan R. Schwartz ,&nbsp;Rami Khayat ,&nbsp;Robin Germany ,&nbsp;Scott McKane ,&nbsp;Matthieu Warde ,&nbsp;Van Ngo ,&nbsp;Sebastien Baillieul ,&nbsp;Sebastien Bailly ,&nbsp;Renaud Tamisier","doi":"10.1016/j.sleep.2024.09.040","DOIUrl":"10.1016/j.sleep.2024.09.040","url":null,"abstract":"<div><h3>Purpose</h3><div>When navigating the landscape of obstructive sleep apnea (OSA), central sleep apnea (CSA) and intersection of the two diseases (co-existing CSA-OSA), there are significant knowledge gaps. Data are scarce regarding the respective prevalence and differences in clinical presentation of the three conditions. One major issue for characterization of the prevalence of the different sleep apnea entities is the scoring of central versus obstructive hypopneas which is not included in the routine practice of many sleep laboratories.</div></div><div><h3>Method</h3><div>We prospectively assessed multidomain symptoms and collected data on comorbidities, medications and treatment indications in a large monocentric real-life dataset (n &gt; 2400) of patients referred for suspicion of sleep apnea. We have systematically distinguished central versus obstructive hypopneas to define OSA, CSA and co-existing CSA-OSA.</div></div><div><h3>Results</h3><div>When CSA was defined by the proportion of central apneas (and hypopneas were considered obstructive by default), the prevalence of CSA was 4.59 % (co-existing CSA-OSA: 11.03 %, and OSA: 84.37 %). When the distinction between obstructive and central hypopneas was used to classify the sleep disordered breathing, the prevalence of CSA was fourfold higher at 19.69 % (co-existing: 19.16 %, OSA: 61.16 %). The burden of cardiovascular and metabolic comorbidities was the highest in the CSA and co-existing sleep apnea subgroups. The three sleep apnea groups exhibited different constellations of symptoms but most of the patients with CSA, co-existing and OSA were symptomatic after comprehensive evaluation. The CSA group exhibited the most severe disturbances in sleep architecture on polysomnography. Therapeutic indications differed depending on the subtype of respiratory events.</div></div><div><h3>Conclusion</h3><div>Our findings imply that <em>not</em> differentiating between central and obstructive hypopneas will underestimate the severity of central sleep disordered breathing abnormalities that mislead therapeutic decisions and might limit improvements in quality of life and sleepiness that are expected in appropriately treated patients with CSA.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 426-433"},"PeriodicalIF":3.8,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between temporomandibular and sleep disorders in adults: An overview of systematic reviews","authors":"Marcelo Rigon ,&nbsp;Karen Obara ,&nbsp;Luana Paixão ,&nbsp;Jefferson Rosa Cardoso ,&nbsp;Almiro José Machado Junior","doi":"10.1016/j.sleep.2024.10.002","DOIUrl":"10.1016/j.sleep.2024.10.002","url":null,"abstract":"<div><h3>Objective</h3><div>This study emphasizes the general relevance of sleep disorders (SD) and temporomandibular disorders (TMD), explores their bidirectional relationship, and describes the importance of systematic reviews in the critical analysis of the literature. This review aimed to comprehensively summarize the relationship between SD and TMD in adults while ensuring a reliable and objective analysis of data from the existing literature.</div></div><div><h3>Methods</h3><div>Systematic reviews were evaluated to investigate this association between two conditions in adults. The study was registered with Prospero and followed the PECOT structure in identifying the research question. Searches in multiple databases were conducted until February 2024 using relevant keywords. The risk of bias was assessed using the Risk of Bias in Systematic Reviews tool, involving two independent reviewers.</div></div><div><h3>Results</h3><div>Data were extracted using different evaluation instruments, and results were analyzed and presented through the synthesis of information collected in selected systematic reviews. The selection included seven systematic reviews of observational studies, with exclusion criteria defined to ensure methodological quality. The results showed that reviewed studies presented clarity and relevance in defining the eligibility criteria, but that the identification and selection of studies, data collection, and synthesis of results varied. Most studies considered the potential risks, but some require greater transparency and methodological rigor.</div></div><div><h3>Conclusions</h3><div>This review points out the association between SD and TMD in adults, with most studies presenting a low risk of bias, although some uncertainties were observed.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 404-415"},"PeriodicalIF":3.8,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142422951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptive sleep behaviours and shift work tolerance during the transition to shift work","authors":"Rachael Harris ,&nbsp;Sean P.A. Drummond ,&nbsp;Ben Meadley ,&nbsp;Shantha M.W. Rajaratnam ,&nbsp;Brett Williams ,&nbsp;Karen Smith ,&nbsp;Kelly-Ann Bowles ,&nbsp;Elle Nguyen ,&nbsp;Megan L. Dobbie ,&nbsp;Alexander P. Wolkow","doi":"10.1016/j.sleep.2024.10.003","DOIUrl":"10.1016/j.sleep.2024.10.003","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate whether recruit paramedics adapt their sleep behaviour during the first 12-months of shift work and to identify sleep behaviours that are associated with better shift work tolerance (SWT) after 12-months of shift work.</div></div><div><h3>Methods</h3><div>Recruit paramedics (n = 105; M_age = 25.81 years; 51.38% female) were evaluated before (baseline), and after six- and 12-months of shift work. At each timepoint, participants completed questionnaires evaluating their mental health and sleep. Participants also underwent 14 days of sleep and shift monitoring (sleep/work diaries and actigraphy) at each timepoint to examine sleep behaviours, including sleep opportunity (SO), sleep regularity and number of sleep episodes.</div></div><div><h3>Results</h3><div>Linear mixed models found SO increased (on day shifts and rest days), and sleep regularity decreased between baseline and follow-up timepoints. There were no changes in SO (on day shifts, nightshifts, and rest days) or sleep regularity between six- and 12-months of shift work. Latent profile analysis at 12-months follow-up identified high (n = 52), medium (n = 27), and low (n = 9) SWT levels (measured via depression, anxiety, insomnia, sleep quality and sleep efficiency) in paramedics. Reduced sleep regularity (i.e., more irregular sleep) between six- and 12-months of work and prioritising major sleep (rather than naps) at six-months predicted high SWT.</div></div><div><h3>Conclusions</h3><div>These findings suggest clear SWT levels exist early in paramedics' careers whereby symptoms of depression, anxiety, and insomnia were the strongest contributors to SWT. New paramedics’ sleep behaviours, including sleep regularity and prioritisation of longer sleep between nightshifts, may play an important role in influencing how paramedics tolerate shift work.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 483-493"},"PeriodicalIF":3.8,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Signal detection of drugs associated with obstructive and central sleep apnoea","authors":"C. Jambon-Barbara ,&nbsp;B. Revol ,&nbsp;A. Hlavaty ,&nbsp;M. Joyeux-Faure ,&nbsp;J.C. Borel ,&nbsp;J.L. Cracowski ,&nbsp;J.L. Pepin ,&nbsp;C. Khouri","doi":"10.1016/j.sleep.2024.09.045","DOIUrl":"10.1016/j.sleep.2024.09.045","url":null,"abstract":"<div><div>We aim to discover new safety signals of drug-induced sleep apnoea (SA), a global health problem affecting approximately 1 billion people worldwide.</div><div>We first conducted a series of sequence symmetry analyses (SSA) in a cohort composed from all patients who received a first SA diagnosis or treatment between 2006 and 2018 in the Echantillon Généraliste des Bénéficaires (EGB), a random sample of the French healthcare database. We used two primary outcomes to estimate the sequence ratio (SR) for all drug classes available in France: a sensitive one (diagnosis or treatment of SA) and a specific one (Positive Airway Pressure (PAP) therapy). We then performed disproportionality analyses using the “Bayesian neural network method” on all cases of sleep apnoea (MedDRA high level term) reported up to November 2023 in the World Health Organisation (WHO) pharmacovigilance database.</div><div>Among the 728,167 individuals, 46,193 had an incident diagnosis or treatment for SA and 17,080 had started an incident treatment by PAP therapy. Fifty-eight drug classes had a significant SR, with 7 considered highly plausible: opium alkaloids and derivatives, benzodiazepine derivatives, other centrally acting agents, other anxiolytics, carbamic acid esters, quinine and derivatives and antivertigo preparations; with consistent signals found for the first 3 drug classes in the disproportionality analysis.</div><div>In this signal detection study, we found that opioids, benzodiazepines (but not Z-drugs) and myorelaxing agents are associated with the onset or aggravation of SA. Moreover, a new safety signal for antivertigo preparations such as betahistine emerged and needs to be further explored.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 315-322"},"PeriodicalIF":3.8,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142376042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}