Pub Date : 2025-02-01DOI: 10.1016/j.sleep.2024.12.002
Tristan Martin , Florane Pasquier , Pierre Denise , Damien Davenne , Gaëlle Quarck
This review attempts to analyze the relationship between the vestibular system and the circadian timing system. The activity of the biological clock allows an organism to optimally perform its tasks throughout the nychtemeron. To achieve this, the biological clock is subjected to exogenous factors that entrain it to a 24h period. While the most powerful synchronizer is the light-dark cycle produced by the Earth's rotation, research has led to the hypothesis of the vestibular system as a possible non-photic time cue used to entrain circadian rhythms. Demonstrated neuroanatomical pathways between vestibular nuclei and suprachiasmatic nuclei could transmit this message. Moreover, functional evidence in both humans and animals has shown that vestibular disruption or stimulation may lead to changes in circadian rhythms characteristics. Vestibular stimulations could be considered to act synergistically with other synchronizers, such as light, to ensure the entrainment of biological rhythms over the 24-h reference period.
{"title":"The relationship between the vestibular system and the circadian timing system: A review","authors":"Tristan Martin , Florane Pasquier , Pierre Denise , Damien Davenne , Gaëlle Quarck","doi":"10.1016/j.sleep.2024.12.002","DOIUrl":"10.1016/j.sleep.2024.12.002","url":null,"abstract":"<div><div>This review attempts to analyze the relationship between the vestibular system and the circadian timing system. The activity of the biological clock allows an organism to optimally perform its tasks throughout the nychtemeron. To achieve this, the biological clock is subjected to exogenous factors that entrain it to a 24h period. While the most powerful synchronizer is the light-dark cycle produced by the Earth's rotation, research has led to the hypothesis of the vestibular system as a possible non-photic time cue used to entrain circadian rhythms. Demonstrated neuroanatomical pathways between vestibular nuclei and suprachiasmatic nuclei could transmit this message. Moreover, functional evidence in both humans and animals has shown that vestibular disruption or stimulation may lead to changes in circadian rhythms characteristics. Vestibular stimulations could be considered to act synergistically with other synchronizers, such as light, to ensure the entrainment of biological rhythms over the 24-h reference period.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"126 ","pages":"Pages 148-158"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.sleep.2024.12.010
Christopher J. Becker , Lynda D. Lisabeth , Guanghao Zhang , Xu Shi , Madeline Kwicklis , Erin Case , Ronald D. Chervin , Devin L. Brown
Background
Sleep-disordered breathing (SDB) is common among stroke survivors and is associated with worse functional, cognitive, and neurologic outcomes after stroke. Little is known about the association between changes in SDB and changes in these outcomes over time.
Methods
Ischemic stroke (IS) patients identified through the Brain Attack Surveillance in Corpus Christi project were offered SDB testing with a portable respiratory monitor (ApneaLink Plus) shortly after stroke, and at 3-, 6-, and 12-months post-stroke. SDB was quantified using the respiratory event index (REI; apneas plus hypopneas per hour of recording). At 3-, 6-, and 12-months post-stroke, functional outcomes, cognitive outcomes, and neurologic outcomes were measured. Linear mixed models were fitted to obtain random slopes reflecting individual changes in REI and each of outcome over time, adjusted for multiple covariates. Associations between the resulting individual slopes for REI and each outcome were then evaluated using linear regression models.
Results
Of 482 IS patients with at least one REI measurement, in fully adjusted models, faster reduction in REI was not associated with faster improvement in functional (β = −0.06; 95 % CI: −0.15, 0.03, p = 0.16), cognitive (β = −0.03; 95 % CI: −0.12, 0.06, p = 0.51), or neurologic outcomes (β = −0.04; 95 % CI: −0.13, 0.05, p = 0.41).
Conclusions
In this observational study of stroke survivors, there was no clear association between the rate of improvement in SDB and improvement in functional, cognitive, or neurologic outcomes. It remains to be seen whether treatment of SDB might lead to improved outcomes among stroke survivors.
{"title":"Changes in sleep-disordered breathing severity and post-stroke outcomes in the first year after stroke","authors":"Christopher J. Becker , Lynda D. Lisabeth , Guanghao Zhang , Xu Shi , Madeline Kwicklis , Erin Case , Ronald D. Chervin , Devin L. Brown","doi":"10.1016/j.sleep.2024.12.010","DOIUrl":"10.1016/j.sleep.2024.12.010","url":null,"abstract":"<div><h3>Background</h3><div>Sleep-disordered breathing (SDB) is common among stroke survivors and is associated with worse functional, cognitive, and neurologic outcomes after stroke. Little is known about the association between changes in SDB and changes in these outcomes over time.</div></div><div><h3>Methods</h3><div>Ischemic stroke (IS) patients identified through the Brain Attack Surveillance in Corpus Christi project were offered SDB testing with a portable respiratory monitor (ApneaLink Plus) shortly after stroke, and at 3-, 6-, and 12-months post-stroke. SDB was quantified using the respiratory event index (REI; apneas plus hypopneas per hour of recording). At 3-, 6-, and 12-months post-stroke, functional outcomes, cognitive outcomes, and neurologic outcomes were measured. Linear mixed models were fitted to obtain random slopes reflecting individual changes in REI and each of outcome over time, adjusted for multiple covariates. Associations between the resulting individual slopes for REI and each outcome were then evaluated using linear regression models.</div></div><div><h3>Results</h3><div>Of 482 IS patients with at least one REI measurement, in fully adjusted models, faster reduction in REI was not associated with faster improvement in functional (β = −0.06; 95 % CI: −0.15, 0.03, p = 0.16), cognitive (β = −0.03; 95 % CI: −0.12, 0.06, p = 0.51), or neurologic outcomes (β = −0.04; 95 % CI: −0.13, 0.05, p = 0.41).</div></div><div><h3>Conclusions</h3><div>In this observational study of stroke survivors, there was no clear association between the rate of improvement in SDB and improvement in functional, cognitive, or neurologic outcomes. It remains to be seen whether treatment of SDB might lead to improved outcomes among stroke survivors.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"126 ","pages":"Pages 167-171"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.sleep.2024.12.006
Ana Duarte , Silvana Martins , Cláudia Augusto , Maria José Silva , Luís Lopes , Rute Santos , Juliana Martins , Rafaela Rosário
This study aims to analyze the associations between sleep characteristics, including sleep opportunity, problems and social jetlag, and toddlers' adiposity. It is part of a larger research project involving 344 children (mean ± SD age of 23.6 ± 6.3 months). Children's length/height, weight and waist circumference were measured at childcare centers. Body Mass Index (BMI), weight-for-length/height, and waist-to-length/height were calculated and classified according to percentiles, serving as surrogates of adiposity. Sleep problems were evaluated through questionnaire. Sleep opportunity was reported by parents and defined as the difference between bedtime and wake-up time. Social jetlag was calculated based on sleep midpoints. Parental questionnaires provided sociodemographic characteristics. Total energy intake was determined from a two-day dietary record, and motor development was assessed using the Bayley-III scales. Generalized linear models were used in the analysis. We found that nighttime sleep opportunity on weekdays was inversely associated with BMI percentile (B = −5.57, 95 % CI -9.79 to −1.35), even with covariates included. Additionally, later bedtime on weekend days were associated with lower weight-for-length/height and waist-to-length/height (B = −4.16, 95 % CI -8.01 to −0.30, and B = −10.62, 95 % CI -15.38 to −5.87, respectively), even when adjusted for potential confounders. Later bedtime on weekdays was associated with lower waist-to-length/height (B = −8.85, 95 % CI -14.95 to −2.74). Social jetlag was associated with lower waist-to-length/height (B = −7.19, 95 % CI -13.47 to −0.90). Future research is needed to clarify these associations and to encourage lifestyle-based interventions aimed at optimizing sleep patterns within this age group.
本研究旨在分析睡眠特征（包括睡眠机会、问题和社会时差）与幼儿肥胖之间的关系。这是一个更大的研究项目的一部分，涉及344名儿童（平均±SD年龄23.6±6.3个月）。在托儿中心测量儿童的身高、体重和腰围。计算身体质量指数（BMI）、体重/身高、腰围/身高，并按百分位数进行分类，作为肥胖的替代指标。通过问卷调查对睡眠问题进行评估。睡眠机会由父母报告，并定义为就寝时间和起床时间之间的差异。社交时差是根据睡眠中点计算的。父母问卷提供了社会人口学特征。从两天的饮食记录中确定总能量摄入，并使用Bayley-III量表评估运动发育。分析中采用广义线性模型。我们发现，即使包括协变量，工作日夜间睡眠时间与BMI百分位数呈负相关（B = -5.57, 95% CI -9.79至-1.35）。此外，周末晚睡与较低的体重/身高和腰长/身高相关（B = -4.16, 95% CI -8.01至-0.30,B = -10.62, 95% CI -15.38至-5.87），即使校正了潜在的混杂因素。工作日较晚的就寝时间与较低的腰长/身高相关（B = -8.85, 95% CI -14.95至-2.74）。社交时差与较低的腰长/身高相关（B = -7.19, 95% CI -13.47至-0.90）。未来的研究需要澄清这些关联，并鼓励以生活方式为基础的干预措施，旨在优化这一年龄组的睡眠模式。
{"title":"Associations between sleep opportunity, sleep problems, and social jetlag and toddlers' adiposity: A cross-sectional study","authors":"Ana Duarte , Silvana Martins , Cláudia Augusto , Maria José Silva , Luís Lopes , Rute Santos , Juliana Martins , Rafaela Rosário","doi":"10.1016/j.sleep.2024.12.006","DOIUrl":"10.1016/j.sleep.2024.12.006","url":null,"abstract":"<div><div>This study aims to analyze the associations between sleep characteristics, including sleep opportunity, problems and social jetlag, and toddlers' adiposity. It is part of a larger research project involving 344 children (mean ± SD age of 23.6 ± 6.3 months). Children's length/height, weight and waist circumference were measured at childcare centers. Body Mass Index (BMI), weight-for-length/height, and waist-to-length/height were calculated and classified according to percentiles, serving as surrogates of adiposity. Sleep problems were evaluated through questionnaire. Sleep opportunity was reported by parents and defined as the difference between bedtime and wake-up time. Social jetlag was calculated based on sleep midpoints. Parental questionnaires provided sociodemographic characteristics. Total energy intake was determined from a two-day dietary record, and motor development was assessed using the Bayley-III scales. Generalized linear models were used in the analysis. We found that nighttime sleep opportunity on weekdays was inversely associated with BMI percentile (B = −5.57, 95 % CI -9.79 to −1.35), even with covariates included. Additionally, later bedtime on weekend days were associated with lower weight-for-length/height and waist-to-length/height (B = −4.16, 95 % CI -8.01 to −0.30, and B = −10.62, 95 % CI -15.38 to −5.87, respectively), even when adjusted for potential confounders. Later bedtime on weekdays was associated with lower waist-to-length/height (B = −8.85, 95 % CI -14.95 to −2.74). Social jetlag was associated with lower waist-to-length/height (B = −7.19, 95 % CI -13.47 to −0.90). Future research is needed to clarify these associations and to encourage lifestyle-based interventions aimed at optimizing sleep patterns within this age group.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"126 ","pages":"Pages 172-177"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.sleep.2024.12.016
Georg Schild , Richard Schreiber , Anke Lux , Sabine Stegemann-Koniszewski , Eva Lücke , Jens Schreiber
Objective/background
Obstructive sleep apnea (OSA) is a common disease, which poses a significant health threat. Initial diagnostics with polygraphy or polysomnography are time consuming and expensive. Therefore, there is an unmet medical need for simplification, especially to exclude healthy patients from elaborate and unnecessary diagnostics. Impulse oscillometry (IOS) is a simple, cheap and noninvasive tool to asses upper airway resistance, which is increased in patients with OSA. The objective was to examine the relationship between IOS parameters and polysomnography in order to evaluate the applicability of IOS as a supplementing tool in OSA diagnostics.
Patients/methods
We performed a prospective, cross-sectional, observational study across 107 participants. Pulmonary function tests with IOS, bodyplethysmography and overnight polysomnography were performed. We computed direct and partial correlations between IOS- and PSG-results. ROC analysis was performed to evaluate the most impactful predictive IOS parameter for diagnosing OSA.
Results
In ROC analysis the predicted probability of resistance at 5Hz (R5%) combined with age showed the highest AUC of 0.919, while R5 at 0.4325kPa/(l/s) provided the optimal cut-off. Correlations between IOS parameters and OSA severity as well as the duration and severity of oxygen desaturation were observed. However, they could not be reproduced as partial correlations after eliminating the BMI as confounding variable.
Conclusion
Our results cannot indicate the usefulness of IOS in OSA diagnostics. The lack of BMI-independent partial correlations between IOS- and PSG-results suggest a correlation without causality fallacy between IOS- and PSG-results. Therefore, the initial impression of good test quality for IOS might be invalid.
{"title":"Prediction of severity of obstructive sleep apnea by awake impulse oscillometry","authors":"Georg Schild , Richard Schreiber , Anke Lux , Sabine Stegemann-Koniszewski , Eva Lücke , Jens Schreiber","doi":"10.1016/j.sleep.2024.12.016","DOIUrl":"10.1016/j.sleep.2024.12.016","url":null,"abstract":"<div><h3>Objective/background</h3><div>Obstructive sleep apnea (OSA) is a common disease, which poses a significant health threat. Initial diagnostics with polygraphy or polysomnography are time consuming and expensive. Therefore, there is an unmet medical need for simplification, especially to exclude healthy patients from elaborate and unnecessary diagnostics. Impulse oscillometry (IOS) is a simple, cheap and noninvasive tool to asses upper airway resistance, which is increased in patients with OSA. The objective was to examine the relationship between IOS parameters and polysomnography in order to evaluate the applicability of IOS as a supplementing tool in OSA diagnostics.</div></div><div><h3>Patients/methods</h3><div>We performed a prospective, cross-sectional, observational study across 107 participants. Pulmonary function tests with IOS, bodyplethysmography and overnight polysomnography were performed. We computed direct and partial correlations between IOS- and PSG-results. ROC analysis was performed to evaluate the most impactful predictive IOS parameter for diagnosing OSA.</div></div><div><h3>Results</h3><div>In ROC analysis the predicted probability of resistance at 5Hz (R5%) combined with age showed the highest AUC of 0.919, while R5 at 0.4325kPa/(l/s) provided the optimal cut-off. Correlations between IOS parameters and OSA severity as well as the duration and severity of oxygen desaturation were observed. However, they could not be reproduced as partial correlations after eliminating the BMI as confounding variable.</div></div><div><h3>Conclusion</h3><div>Our results cannot indicate the usefulness of IOS in OSA diagnostics. The lack of BMI-independent partial correlations between IOS- and PSG-results suggest a correlation without causality fallacy between IOS- and PSG-results. Therefore, the initial impression of good test quality for IOS might be invalid.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"126 ","pages":"Pages 218-221"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.sleep.2024.12.011
Yuan Shi , Xin Tian , Taomei Li , Yuexia Hu , Yuqing Xie , Huixian Li , Yun Li , Ning Jiang , Xiangdong Tang , Yanyan Wang
Objective
To evaluate the instant impact of transcranial alternating current stimulation (tACS) on sleep brain oscillations.
Methods
Thirty-six healthy subjects were randomly assigned to receive tACS and sham stimulation in a crossover design separated by a one-week washout period. After stimulation, a 2-h nap polysomnography (PSG) was performed to obtain Electroencephalogram (EEG) data and objective sleep variables, and self-reported subjective sleep parameters were collected at the end of the nap. EEG spectral analyses were conducted on the EEG data to obtain the absolute and relative power for each sleep stage during the nap. The associations between power values and objective and subjective measurements were analyzed using Spearman or Pearson correlation coefficients.
Results
The tACS group presented higher power in slow wave activity (SWA) and delta frequency bands and lower alpha, sigma and beta power values compared to the sham group during the N2 and N3 sleep stages. SWA and delta power were positively associated with sleep duration and sleep efficiency relevant parameters; while alpha, sigma and beta power were positively associated with prolonged sleep latency and wakefulness related variables. PSG, self-reported and sleep diary measured objective and subjective sleep parameters were comparable between the tACS and the sham groups.
Conclusion
Our results support that tACS could promote sleep depth in microstructure of sleep EEG, manifesting as an increase in EEG spectral power in low frequency bands and a decrease in high frequency bands.
The registration number of this study is ChiCTR2200063729.
{"title":"The influence of transcranial alternating current stimulation on EEG spectral power during subsequent sleep: A randomized crossover study","authors":"Yuan Shi , Xin Tian , Taomei Li , Yuexia Hu , Yuqing Xie , Huixian Li , Yun Li , Ning Jiang , Xiangdong Tang , Yanyan Wang","doi":"10.1016/j.sleep.2024.12.011","DOIUrl":"10.1016/j.sleep.2024.12.011","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the instant impact of transcranial alternating current stimulation (tACS) on sleep brain oscillations.</div></div><div><h3>Methods</h3><div>Thirty-six healthy subjects were randomly assigned to receive tACS and sham stimulation in a crossover design separated by a one-week washout period. After stimulation, a 2-h nap polysomnography (PSG) was performed to obtain Electroencephalogram (EEG) data and objective sleep variables, and self-reported subjective sleep parameters were collected at the end of the nap. EEG spectral analyses were conducted on the EEG data to obtain the absolute and relative power for each sleep stage during the nap. The associations between power values and objective and subjective measurements were analyzed using Spearman or Pearson correlation coefficients.</div></div><div><h3>Results</h3><div>The tACS group presented higher power in slow wave activity (SWA) and delta frequency bands and lower alpha, sigma and beta power values compared to the sham group during the N2 and N3 sleep stages. SWA and delta power were positively associated with sleep duration and sleep efficiency relevant parameters; while alpha, sigma and beta power were positively associated with prolonged sleep latency and wakefulness related variables. PSG, self-reported and sleep diary measured objective and subjective sleep parameters were comparable between the tACS and the sham groups.</div></div><div><h3>Conclusion</h3><div>Our results support that tACS could promote sleep depth in microstructure of sleep EEG, manifesting as an increase in EEG spectral power in low frequency bands and a decrease in high frequency bands.</div><div>The registration number of this study is ChiCTR2200063729.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"126 ","pages":"Pages 185-193"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.sleep.2024.12.025
Wuyuan Xin , Ting Xue , Yongxin Cheng , Fang Dong , Juan Wang , Yuxin Ma , Shan Zhang , Fan Zhang , Jingjing Ding , Daining Song , Junxuan Wang , Yifei Zhu , Haitao Ju , Kai Yuan , Xiaona Sheng , Dahua Yu
Aims
The objective of the current study was to investigate the dynamic functional connectivity among large-scale brain networks in patients with insomnia, and to assess the efficacy of repetitive transcranial magnetic stimulation (rTMS) treatment in these individuals.
Methods
Resting-state functional magnetic resonance imaging (rs-fMRI) data from 62 insomnia patients and 69 healthy controls were used to compare differences in dynamic functional connectivity between the two groups. A total of 26 insomnia patients underwent rTMS for four weeks. Changes in dynamic functional network connectivity was observed in insomnia patients following treatment. Additionally, the relationship between clinical symptoms and insomnia was analyzed using topological and correlation analyses.
Results
Our findings demonstrated that insomnia patients exhibited a significantly lower fraction rate of negative connectivity between the dorsal default mode network (dDMN) and the visual network (VN) compared to healthy controls, while showing strong positive connectivity within the VN and the auditory network (AUN). It may be attributed to the restoration of normal dynamic functional connectivity between the dDMN and VN in insomnia patients following rTMS. Furthermore, the dynamic functional connectivity between the dDMN and VN was found to predict sleep quality and treatment outcome in insomnia patients.
Conclusion
Abnormal dynamic functional network connectivity between the dDMN and VN is a hallmark of insomnia, and may serve as a biomarker to assess the effects of rTMS treatment in insomnia patients.
{"title":"Reconfigurations of dynamic functional network connectivity after 1HZ repetitive transcranial magnetic stimulation in insomnia disorder","authors":"Wuyuan Xin , Ting Xue , Yongxin Cheng , Fang Dong , Juan Wang , Yuxin Ma , Shan Zhang , Fan Zhang , Jingjing Ding , Daining Song , Junxuan Wang , Yifei Zhu , Haitao Ju , Kai Yuan , Xiaona Sheng , Dahua Yu","doi":"10.1016/j.sleep.2024.12.025","DOIUrl":"10.1016/j.sleep.2024.12.025","url":null,"abstract":"<div><h3>Aims</h3><div>The objective of the current study was to investigate the dynamic functional connectivity among large-scale brain networks in patients with insomnia, and to assess the efficacy of repetitive transcranial magnetic stimulation (rTMS) treatment in these individuals.</div></div><div><h3>Methods</h3><div>Resting-state functional magnetic resonance imaging (rs-fMRI) data from 62 insomnia patients and 69 healthy controls were used to compare differences in dynamic functional connectivity between the two groups. A total of 26 insomnia patients underwent rTMS for four weeks. Changes in dynamic functional network connectivity was observed in insomnia patients following treatment. Additionally, the relationship between clinical symptoms and insomnia was analyzed using topological and correlation analyses.</div></div><div><h3>Results</h3><div>Our findings demonstrated that insomnia patients exhibited a significantly lower fraction rate of negative connectivity between the dorsal default mode network (dDMN) and the visual network (VN) compared to healthy controls, while showing strong positive connectivity within the VN and the auditory network (AUN). It may be attributed to the restoration of normal dynamic functional connectivity between the dDMN and VN in insomnia patients following rTMS. Furthermore, the dynamic functional connectivity between the dDMN and VN was found to predict sleep quality and treatment outcome in insomnia patients.</div></div><div><h3>Conclusion</h3><div>Abnormal dynamic functional network connectivity between the dDMN and VN is a hallmark of insomnia, and may serve as a biomarker to assess the effects of rTMS treatment in insomnia patients.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"126 ","pages":"Pages 239-247"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.sleep.2024.12.027
Hanseul Kim , Kyung Hwa Lee , Jiyoon Shin , Won Woo Seo , Jeong Eun Jeon , Ha Young Lee , Jin Hyeok You , Sun-Young Kim , Seog Ju Kim , Yu Jin Lee
Introduction
Shift work disrupts circadian rhythms, causing sleep and mood problems. Sleep reactivity—the sensitivity of sleep to stress—may affect how shift workers cope with these disruptions. This study investigated the relationship between sleep reactivity and shift work, exploring associations between sleep reactivity and sleep disturbance, mood symptoms, and quality of life in shift workers.
Methods
In a cross-sectional design, 132 participants (79 shift workers and 53 controls) were assessed using the Ford Insomnia Response to Stress Test (FIRST), Insomnia Severity Index (ISI), Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and World Health Organization Quality of Life (WHOQOL). We compared the self-reported measurements between shift workers and controls. Two-way ANOVA was performed to explore the interaction effects between shift work and sleep reactivity on sleep, mood parameters, and quality of life. Multiple linear regression analysis was conducted to identify factors associated with sleep, mood, and quality of life among shift workers.
Results
Shift workers scored higher on ISI and BDI compared to controls. Two-way ANOVA revealed an interaction effect between shift work and sleep reactivity on WHOQOL. Regression analysis indicated that high sleep reactivity was associated with higher ISI, BDI, BAI, and lower WHOQOL among shift workers.
Conclusion
Sleep reactivity significantly affected shift worker’s quality of life. Our findings indicate that high sleep reactivity in shift workers was associated with increased sleep disturbance, mood problems, and decreased quality of life, implying that sleep reactivity may predict shift work tolerance.
{"title":"High sleep reactivity in shift workers is associated with increased sleep disturbance, mood problems, and reduced quality of life","authors":"Hanseul Kim , Kyung Hwa Lee , Jiyoon Shin , Won Woo Seo , Jeong Eun Jeon , Ha Young Lee , Jin Hyeok You , Sun-Young Kim , Seog Ju Kim , Yu Jin Lee","doi":"10.1016/j.sleep.2024.12.027","DOIUrl":"10.1016/j.sleep.2024.12.027","url":null,"abstract":"<div><h3>Introduction</h3><div>Shift work disrupts circadian rhythms, causing sleep and mood problems. Sleep reactivity—the sensitivity of sleep to stress—may affect how shift workers cope with these disruptions. This study investigated the relationship between sleep reactivity and shift work, exploring associations between sleep reactivity and sleep disturbance, mood symptoms, and quality of life in shift workers.</div></div><div><h3>Methods</h3><div>In a cross-sectional design, 132 participants (79 shift workers and 53 controls) were assessed using the Ford Insomnia Response to Stress Test (FIRST), Insomnia Severity Index (ISI), Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and World Health Organization Quality of Life (WHOQOL). We compared the self-reported measurements between shift workers and controls. Two-way ANOVA was performed to explore the interaction effects between shift work and sleep reactivity on sleep, mood parameters, and quality of life. Multiple linear regression analysis was conducted to identify factors associated with sleep, mood, and quality of life among shift workers.</div></div><div><h3>Results</h3><div>Shift workers scored higher on ISI and BDI compared to controls. Two-way ANOVA revealed an interaction effect between shift work and sleep reactivity on WHOQOL. Regression analysis indicated that high sleep reactivity was associated with higher ISI, BDI, BAI, and lower WHOQOL among shift workers.</div></div><div><h3>Conclusion</h3><div>Sleep reactivity significantly affected shift worker’s quality of life. Our findings indicate that high sleep reactivity in shift workers was associated with increased sleep disturbance, mood problems, and decreased quality of life, implying that sleep reactivity may predict shift work tolerance.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"126 ","pages":"Pages 275-281"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.sleep.2024.11.031
Courtney B. Worley , Sarah Meshberg-Cohen , Ian C. Fischer , Robert H. Pietrzak
Study objectives
Trauma-exposed veterans may be at an increased risk for nightmares. To date, however, no known study has examined the prevalence, risk factors, and comorbidities of nightmares in a nationally representative sample of veterans.
Methods
A nationally representative sample of 4069 US military veterans completed a survey that assessed trauma-related nightmares, health histories, and functioning. Multivariable analyses examined the association between trauma-related nightmares, and sociodemographic, military, and trauma characteristics, and psychiatric and functioning measures.
Results
Lifetime trauma-related nightmares were endorsed by 15.0 % of the sample, with 6.4 % endorsing nightmares in the past month. Sociodemographic factors, exposure to adverse childhood events, number of deployments, and index trauma type were all associated with trauma-related nightmares. In addition, nightmares were associated with elevated odds of psychiatric conditions, worse health and psychosocial functioning, and suicidal ideation and future suicidal intent. A "dose-response" association was observed between nightmare severity and suicidal ideation, even after controlling for sociodemographic characteristics, trauma exposure, and psychiatric and medical conditions.
Conclusions
Nearly 1-in-6 veterans experience trauma-related nightmares in their lifetime, which is associated with adverse mental health, functional difficulties, and increased suicide risk. Results underscore the importance of transdiagnostic assessment, monitoring, and treatment of trauma-related nightmares in this population.
{"title":"Trauma-related nightmares among U.S. veterans: Findings from a nationally representative study","authors":"Courtney B. Worley , Sarah Meshberg-Cohen , Ian C. Fischer , Robert H. Pietrzak","doi":"10.1016/j.sleep.2024.11.031","DOIUrl":"10.1016/j.sleep.2024.11.031","url":null,"abstract":"<div><h3>Study objectives</h3><div>Trauma-exposed veterans may be at an increased risk for nightmares. To date, however, no known study has examined the prevalence, risk factors, and comorbidities of nightmares in a nationally representative sample of veterans.</div></div><div><h3>Methods</h3><div>A nationally representative sample of 4069 US military veterans completed a survey that assessed trauma-related nightmares, health histories, and functioning. Multivariable analyses examined the association between trauma-related nightmares, and sociodemographic, military, and trauma characteristics, and psychiatric and functioning measures.</div></div><div><h3>Results</h3><div>Lifetime trauma-related nightmares were endorsed by 15.0 % of the sample, with 6.4 % endorsing nightmares in the past month. Sociodemographic factors, exposure to adverse childhood events, number of deployments, and index trauma type were all associated with trauma-related nightmares. In addition, nightmares were associated with elevated odds of psychiatric conditions, worse health and psychosocial functioning, and suicidal ideation and future suicidal intent. A \"dose-response\" association was observed between nightmare severity and suicidal ideation, even after controlling for sociodemographic characteristics, trauma exposure, and psychiatric and medical conditions.</div></div><div><h3>Conclusions</h3><div>Nearly 1-in-6 veterans experience trauma-related nightmares in their lifetime, which is associated with adverse mental health, functional difficulties, and increased suicide risk. Results underscore the importance of transdiagnostic assessment, monitoring, and treatment of trauma-related nightmares in this population.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"126 ","pages":"Pages 159-166"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.sleep.2024.12.014
Kun-Tai Kang , Ming-Tzer Lin , Meiho Nakayama , Yi-Ho Young , Wei-Chung Hsu
Background
Several studies have demonstrated a relationship between vertigo and obstructive sleep apnea (OSA) in adults. This review examined the association between vertigo and OSA and investigated the effects of OSA treatment on vestibular function.
Methods
Searches were conducted in PubMed, MEDLINE, EMBASE, Cochrane, Scopus, and Web of Science databases. Two authors independently searched the databases up to November 2023. Meta-analysis of caloric test, cervical vestibular evoked myogenic potential (cVEMP), and ocular vestibular evoked myogenic potential (oVEMP), between adults with and without OSA was done.
Results
Overall, 28 studies were identified, and most of which focused on vestibular dysfunction in the OSA group. Compared with controls, adults with OSA had an increased risk of abnormal caloric test results (odds ratio [OR] = 4.8), absence of cVEMP (OR = 7.9), absence of oVEMP (OR = 6.2), decreased n1p2 amplitude (standardized mean difference [SMD] = −0.78), decreased p1n1 amplitude (SMD = −0.92), decreased p1n1 interval (SMD = −2.37) in cVEMP testing and prolonged n1 latency (SMD = 0.81) and decreased p1n1 amplitude (SMD = −0.51) in oVEMP testing. Three population-based studies implied a high risk of vertigo in adult OSA, although not statistically significant (OR = 2.53, 95 % confidence interval = 0.97 to 6.61). According to 3 studies, OSA is relatively prevalent among patients with vertigo. Another 3 studies regarding OSA treatment on vestibular functions revealed inconsistent findings.
Conclusion
Adults with OSA exhibit abnormalities in caloric, cVEMP, and oVEMP test results, indicating impairments in the semicircular canal, saccule, and utricle.
{"title":"Association of vertigo with adult obstructive sleep apnea: A systematic review and meta-analysis","authors":"Kun-Tai Kang , Ming-Tzer Lin , Meiho Nakayama , Yi-Ho Young , Wei-Chung Hsu","doi":"10.1016/j.sleep.2024.12.014","DOIUrl":"10.1016/j.sleep.2024.12.014","url":null,"abstract":"<div><h3>Background</h3><div>Several studies have demonstrated a relationship between vertigo and obstructive sleep apnea (OSA) in adults. This review examined the association between vertigo and OSA and investigated the effects of OSA treatment on vestibular function.</div></div><div><h3>Methods</h3><div>Searches were conducted in PubMed, MEDLINE, EMBASE, Cochrane, Scopus, and Web of Science databases. Two authors independently searched the databases up to November 2023. Meta-analysis of caloric test, cervical vestibular evoked myogenic potential (cVEMP), and ocular vestibular evoked myogenic potential (oVEMP), between adults with and without OSA was done.</div></div><div><h3>Results</h3><div>Overall, 28 studies were identified, and most of which focused on vestibular dysfunction in the OSA group. Compared with controls, adults with OSA had an increased risk of abnormal caloric test results (odds ratio [OR] = 4.8), absence of cVEMP (OR = 7.9), absence of oVEMP (OR = 6.2), decreased n1p2 amplitude (standardized mean difference [SMD] = −0.78), decreased p1n1 amplitude (SMD = −0.92), decreased p1n1 interval (SMD = −2.37) in cVEMP testing and prolonged n1 latency (SMD = 0.81) and decreased p1n1 amplitude (SMD = −0.51) in oVEMP testing. Three population-based studies implied a high risk of vertigo in adult OSA, although not statistically significant (OR = 2.53, 95 % confidence interval = 0.97 to 6.61). According to 3 studies, OSA is relatively prevalent among patients with vertigo. Another 3 studies regarding OSA treatment on vestibular functions revealed inconsistent findings.</div></div><div><h3>Conclusion</h3><div>Adults with OSA exhibit abnormalities in caloric, cVEMP, and oVEMP test results, indicating impairments in the semicircular canal, saccule, and utricle.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"126 ","pages":"Pages 194-204"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Among the mental health outcomes and disaster types (determined by damage to life, property, long-term consequences, displacement, and unpredictability), floods are associated with anxiety and sleep problems, mudslides with anxiety and mood disturbance, volcanic eruptions with acute stress reactions, and earthquakes with anxiety, depression, and physical complaints. Disasters such as tunnel collapse are unique as it involves the healthy, without loss of personal property or displacement; hence, they can have very different health-related outcomes. In this study, we explore mental health and sleep-related issues in workers rescued from an under-construction collapsed tunnel trapped for 17 days. After the initial triage and stabilization and a detailed evaluation of their physical and mental health status, the participants responded to self-administered scales for assessing anxiety [Generalized Anxiety Disorder-7], depression [Patient Health Questionnaire-9], and insomnia [Insomnia Severity Index] in the local language (Hindi). A separate research team conducted open-ended interviews to explore daily routines and concerns, circadian rhythm, orientation to time and day of tunnel collapse to day of rescue events, and sleep routine (and other nuances such as sleep quality and daytime napping) during the 17 days of entrapment. Thirty-three workers consented and hailed from the northern and eastern states of India. They report a mix of hope and worry in the initial days. On the assessment of anxiety, depression, and sleep, only 2–5 scored above the cut-off value, and scales correlated with each other, though clinically it had no bearing. One-third were disoriented to the passage of time, which was related to difficulty falling asleep and more napping. Daytime napping was associated with delayed waketime. Those depressed had more difficulty in the onset, maintinance, and termination of sleep, and reduced total sleep time. Victims of tunnel collapse experience a different set of mental health and sleep problems compared to those reported in other disasters. The findings can partly be attributed to the disruption of light-dark cycles. As only a fraction develops these problems, there is a need for triaging while providing mental health and sleep-related interventions in such circumstances. Lastly, there is a need to establish a light-dark cycle to prevent disorientation among victims.
{"title":"Mental health and sleep routines: Uttarkashi, India tunnel collapse workers’ experience","authors":"Kaustav Kundu , Anindya Das , Gaurav Kachhawaha , Swastika Jhajharia , Bavneet Kaur , Khushboo Mudgal , Chandni Sharma , Dikshya Neupane , Zeba Khan , Ravi Kant , Mukesh Bairwa , Sahil Kumar , Balachandra Routhu , Ravi Kumar , Meenu Singh , Ravi Gupta","doi":"10.1016/j.sleep.2024.12.017","DOIUrl":"10.1016/j.sleep.2024.12.017","url":null,"abstract":"<div><div>Among the mental health outcomes and disaster types (determined by damage to life, property, long-term consequences, displacement, and unpredictability), floods are associated with anxiety and sleep problems, mudslides with anxiety and mood disturbance, volcanic eruptions with acute stress reactions, and earthquakes with anxiety, depression, and physical complaints. Disasters such as tunnel collapse are unique as it involves the healthy, without loss of personal property or displacement; hence, they can have very different health-related outcomes. In this study, we explore mental health and sleep-related issues in workers rescued from an under-construction collapsed tunnel trapped for 17 days. After the initial triage and stabilization and a detailed evaluation of their physical and mental health status, the participants responded to self-administered scales for assessing anxiety [Generalized Anxiety Disorder-7], depression [Patient Health Questionnaire-9], and insomnia [Insomnia Severity Index] in the local language (Hindi). A separate research team conducted open-ended interviews to explore daily routines and concerns, circadian rhythm, orientation to time and day of tunnel collapse to day of rescue events, and sleep routine (and other nuances such as sleep quality and daytime napping) during the 17 days of entrapment. Thirty-three workers consented and hailed from the northern and eastern states of India. They report a mix of hope and worry in the initial days. On the assessment of anxiety, depression, and sleep, only 2–5 scored above the cut-off value, and scales correlated with each other, though clinically it had no bearing. One-third were disoriented to the passage of time, which was related to difficulty falling asleep and more napping. Daytime napping was associated with delayed waketime. Those depressed had more difficulty in the onset, maintinance, and termination of sleep, and reduced total sleep time. Victims of tunnel collapse experience a different set of mental health and sleep problems compared to those reported in other disasters. The findings can partly be attributed to the disruption of light-dark cycles. As only a fraction develops these problems, there is a need for triaging while providing mental health and sleep-related interventions in such circumstances. Lastly, there is a need to establish a light-dark cycle to prevent disorientation among victims.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"126 ","pages":"Pages 329-335"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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