Smart Materials in Medicine最新文献_第3页

Advancements in graphene-based composites: A review of the emerging applications in healthcare 石墨烯基复合材料的进展：在医疗保健中的新兴应用综述

Q1 Engineering

Smart Materials in Medicine

Pub Date : 2025-03-01 DOI: 10.1016/j.smaim.2025.01.001

Farwa Batool , Saz Muhammad , Rabia Muazzam , Muhammad Waqas , Zia Ullah , Shubham Roy , Yinghe Zhang , Ke Wang , Bing Guo

Graphene and related materials are emerging revolutionary materials due to fascinating stimuli-responsive physiochemical properties having widespread applications in developing advanced nano-systems for detection, diagnostics, and therapeutics in biomedical fields. Various materials like metal nanoparticles, polymers, dyes, drugs, and proteins could be combined yielding graphene-based composite materials (GBCMs) to synergistically fulfill different biomedical requirements. The 2D conjugated structure, easy surface functionalization via covalent or van der Waal interactions, and combination with different components for versatile functionalities altogether contribute to the development of GBCM for healthcare applications. This review specifically focuses on GBCMs and discusses specific material properties relevant to their material applications in healthcare. Furthermore, the synthesis, toxicity, and biocompatibility of these GBCMs, and their interactions with biological materials are thoroughly discussed. Importantly, the recent cutting-edge applications in the field of healthcare, including its role in the development of antibacterial, anti-viral, and photothermal therapies, wound healing, drug delivery, neurodegenerative disease therapy, and biosensing based on GBCMs are well-updated. Additionally, the applications of GBCMs in point-of-care devices, wearable electronics, and tissue engineering are well summarized. We hope this review opens up more possibilities to design more innovative healthcare materials derived from graphene.

石墨烯及相关材料是新兴的革命性材料，具有令人着迷的刺激响应理化特性，可广泛应用于开发先进的纳米系统，用于生物医学领域的检测、诊断和治疗。各种材料（如金属纳米颗粒、聚合物、染料、药物和蛋白质）可结合成石墨烯基复合材料 (GBCM)，从而协同满足不同的生物医学要求。二维共轭结构、易于通过共价或范德华相互作用实现表面功能化，以及与不同成分的组合可实现多种功能，这些都有助于开发用于医疗保健应用的 GBCM。本综述特别关注 GBCM，并讨论了与它们在医疗保健领域的材料应用相关的具体材料特性。此外，还深入讨论了这些 GBCM 的合成、毒性、生物相容性及其与生物材料的相互作用。重要的是，该书更新了最近在医疗保健领域的前沿应用，包括基于 GBCMs 的抗菌、抗病毒和光热疗法、伤口愈合、药物输送、神经退行性疾病治疗和生物传感的发展。此外，我们还总结了 GBCM 在护理点设备、可穿戴电子设备和组织工程中的应用。我们希望这篇综述能为设计更多源自石墨烯的创新医疗材料提供更多可能性。

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引用次数: 0

Biomimetic 3D printing of photocrosslinkable biodegradable elastomers-modified hybrid scaffolds as instructive platforms for bone tissue regeneration 光交联可生物降解弹性体改性复合支架的仿生3D打印作为骨组织再生的指导平台

Q1 Engineering

Smart Materials in Medicine

Pub Date : 2025-03-01 DOI: 10.1016/j.smaim.2024.12.001

Panyu Zhou , Jiayi Wang , Hongrui Wang , Hao Pan , Hengsong Shi , Yu Fu , Yuan Yuan , Yang Wang , Qi Gan , Changsheng Liu

3D printing is regarded as an ideal method for large-scale bone defect repair. A rapid curing rate and strong mechanical properties throughout the product's shelf life are key development goals in 3D-printed bone repair biomaterials. To achieve this goal, we developed a 3D-printable organic/inorganic composite ink featuring rapid curing and highly customizable properties. After 3D printing, the nanocomposite ink of poly (glyceryl sebacate)-2-chlorocinnamoyl chloride/β-tricalcium phosphate (PGS-CC/β-TCP) undergoes short-term light crosslinking to form a biomimetic network of inorganic-organic composite materials. The resulting bone repair scaffold possesses excellent mechanical properties, significantly promotes cell adhesion and proliferation, and demonstrates good in vitro osteogenic activity, angiogenic performance, and mineralization capability. Moreover, the PGS-CC/β-TCP 3D-printed scaffold exhibits good degradation performance, retaining its mechanical properties even after four weeks of degradation. The PGS-CC(1:2)/β-TCP composite scaffold can effectively repair severe cranial bone defects in rats, showing optimal in vivo osteogenic and degradation performance at 6 and 12 weeks. With these advantages, this innovative 3D-printed biomaterial has great clinical application prospects for large segment bone repair and provides new opportunities for other complex reconstructions.

3D打印被认为是大规模骨缺损修复的理想方法。在整个产品保质期内，快速的固化速度和强大的机械性能是3d打印骨修复生物材料的关键发展目标。为了实现这一目标，我们开发了一种3d打印的有机/无机复合油墨，具有快速固化和高度可定制的特性。3D打印后，聚癸二酸甘油-2-氯肉桂酰氯/β-磷酸三钙（PGS-CC/β-TCP）纳米复合油墨进行短期光交联，形成无机-有机复合材料仿生网络。所制备的骨修复支架具有优异的力学性能，显著促进细胞粘附和增殖，并具有良好的体外成骨活性、血管生成性能和矿化能力。此外，PGS-CC/β-TCP 3d打印支架具有良好的降解性能，即使在降解四周后仍保持其机械性能。PGS-CC(1:2)/β-TCP复合支架可以有效修复大鼠严重颅骨缺损，在6周和12周时表现出最佳的体内成骨和降解性能。具有这些优点，这种创新的3d打印生物材料在大节段骨修复方面具有很大的临床应用前景，也为其他复杂的重建提供了新的机会。

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引用次数: 0

Bright antimicrobial surfaces based on Schottky interfaces: From light illumination to bacterial charging 基于肖特基界面的明亮抗菌表面：从光照到细菌充电

Q1 Engineering

Smart Materials in Medicine

Pub Date : 2025-03-01 DOI: 10.1016/j.smaim.2025.02.001

Zubair Ahmed , Zhong Wang , Muhammed Adil , Ijaz Ahmad Bhatti , Huiliang Cao

The growing threat of resistant bacterial infections is a global concern. Therefore, it is crucial to discover new antimicrobial agents or alternative mechanisms to address this issue. This article explores the potential of smart antimicrobial surfaces based on Schottky interfaces for mitigating bacterial infections. The article proposes combining the biological features of bacterial cells with the physics of Schottky-Mott theory to describe and explain the disinfection behaviors of Schottky interfaces. The physicochemical properties and associated characterization methods of Schottky interfaces are examined to uncover their smart pathways leading to disinfection. The fabrication of antimicrobial Schottky interfaces is explored, focusing on techniques such as sputtering, evaporation, chemical deposition, and ion implantation. The advantages and challenges of each method are highlighted, along with recent research on their use to create antimicrobial surfaces over different activating procedures, ranging from light adsorption to bacterial charging and capacitive charge storage. Overall, this article provides a comprehensive overview of the knowledge and advancements in smart antimicrobial surfaces based on Schottky interfaces, emphasizing their potential in combating bacterial infections and offering insights into their properties, fabrication, and applications. The article concludes by illuminating the need for additional research to completely understand the dark behaviors of Schottky interfaces against microbes and harness their full potential in smart coating developments.

耐药细菌感染日益严重的威胁是一个全球关注的问题。因此，发现新的抗菌药物或替代机制来解决这一问题至关重要。本文探讨了基于肖特基界面的智能抗菌表面的潜力，以减轻细菌感染。本文提出将细菌细胞的生物学特性与肖特基-莫特理论的物理学相结合，来描述和解释肖特基界面的消毒行为。研究了肖特基界面的物理化学性质和相关表征方法，以揭示其导致消毒的智能途径。探讨了抗菌肖特基界面的制备，重点研究了溅射、蒸发、化学沉积和离子注入等技术。强调了每种方法的优点和挑战，以及最近关于它们在不同激活程序（从光吸附到细菌充电和电容电荷存储）上用于创建抗菌表面的研究。总体而言，本文全面概述了基于肖特基界面的智能抗菌表面的知识和进展，强调了它们在对抗细菌感染方面的潜力，并提供了对其特性、制造和应用的见解。文章最后指出，需要进一步的研究来完全理解肖特基界面对微生物的暗行为，并充分利用它们在智能涂层开发中的潜力。

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引用次数: 0

Nanoparticles, a promising treatment for gastric cancer 纳米粒子，一种很有前景的胃癌治疗方法

Q1 Engineering

Smart Materials in Medicine

Pub Date : 2025-03-01 DOI: 10.1016/j.smaim.2025.01.002

Di Hua , Xiexing Wu , Zebin Wu , Chunyang Fan , Jiale Wang , Wei He , Yongkang Deng , Yao Zhang , Hengxiang Shu , Meng Shen , Dechun Geng , Kai Chen

Globally, gastric cancer (GC), as a fatal malignant tumor, remains a significant health challenge. Thus, it is imperative to explore novel treatment strategies. Despite the fact that the survival rate of GC has improved over the past few decades, the median survival for patients with advanced GC is still less than one year. Recently, nanoparticles (NPs), as a potential approach for designing new treatment strategies, such as gold NPs (AuNPs) and metal oxides NPs (MONPs), not only possesses advantages such as multi-functional imaging and high stability, but also can deliver drugs, simultaneously achieve diagnostic and therapeutic effects. With the development and maturation of this technology, an increasing number of nano-drugs have been utilized in the diagnosis and treatment of GC. In this review, we have provided a detailed and separate elaboration on the NPs that play diagnostic, therapeutic and dual-functional roles in GC-related research. We also introduce the clinical research of nanomedicine in GC over the past few decades. Furthermore, we probed into the limitations of contemporary nanomedicine treatments and the future research directions.

胃癌作为一种致命的恶性肿瘤，在全球范围内仍然是一个重大的健康挑战。因此，探索新的治疗策略势在必行。尽管在过去的几十年里，胃癌的生存率有所提高，但晚期胃癌患者的中位生存期仍然不足一年。近年来，纳米颗粒（NPs）作为设计金纳米颗粒（AuNPs）和金属氧化物纳米颗粒（MONPs）等新型治疗策略的一种潜在途径，不仅具有多功能成像和高稳定性等优点，而且可以作为药物的载体，同时实现诊断和治疗的效果。随着该技术的发展和成熟，越来越多的纳米药物被用于气相色谱的诊断和治疗。在这篇综述中，我们对在气相色谱相关研究中发挥诊断、治疗和双重功能作用的NPs进行了详细和单独的阐述。介绍了近几十年来纳米药物在GC中的临床研究情况。此外，我们还探讨了当代纳米医学治疗的局限性和未来的研究方向。

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引用次数: 0

A polymeric dexamethasone prodrug attenuates focal segmental glomerulosclerosis (FSGS) in an Adriamycin-induced mouse model with minimal glucocorticoid side effects 聚合物地塞米松前药在阿霉素诱导的小鼠模型中减轻局灶性节段性肾小球硬化（FSGS），糖皮质激素副作用最小

Q1 Engineering

Smart Materials in Medicine

Pub Date : 2025-03-01 DOI: 10.1016/j.smaim.2025.02.003

Haochen Jiang , Xin Fu , Salma Althobaiti , Braeden Pinkerton , Shabnam Arash , Xiaoqing Du , Zhenshan Jia , Fang Yu , Kirk W. Foster , Geoffrey M. Thiele , Troy J. Plumb , Dong Wang

Focal segmental glomerulosclerosis (FSGS) is chronic renal injury characterized by proteinuria and podocyte injury with glomerulus scarring and tubulointerstitial fibrosis. Glucocorticoids (GCs) are the current first-line treatment. Long-term use of GCs, however, is associated with numerous off-target adverse effects. Thus, there is an urgent unmet clinical need for novel FSGS therapies. Recognizing potent efficacy of GCs in managing FSGS, we proposed the use of a polyethylene glycol (PEG)-based nephrotropic dexamethasone (Dex) prodrug (ZSJ-0228 or PEG-Dex) to mitigate the GC side effects. The focus of the present study was to assess the therapeutic efficacy and safety of PEG-Dex in an Adriamycin-induced BALB/c mouse model of FSGS. A single dose of PEG-Dex treatment (35 mg/kg Dex dose equivalent) effectively reduced the proteinuria level, ameliorated FSGS lesions and restored kidney function when compared to the dose equivalent daily Dex treatment and Saline control. Additionally, PEG-Dex treatment also showed a much-improved safety profile than Dex with minimal adverse events detected. Collectively, these data suggest that PEG-Dex may be established as a promising drug candidate for more effective and safe clinical treatment of FSGS.

局灶节段性肾小球硬化（FSGS）是一种以蛋白尿和足细胞损伤为特征的慢性肾损伤，伴肾小球瘢痕和小管间质纤维化。糖皮质激素（GCs）是目前的一线治疗方法。然而，长期使用GCs与许多脱靶不良反应有关。因此，迫切需要新的FSGS治疗方法。认识到GC在治疗FSGS中的有效作用，我们建议使用聚乙二醇（PEG）基肾促性地塞米松（Dex）前药（ZSJ-0228或PEG-Dex）来减轻GC的副作用。本研究的重点是评估PEG-Dex对阿霉素诱导的FSGS BALB/c小鼠模型的治疗效果和安全性。单剂量PEG-Dex治疗（35 mg/kg Dex剂量当量）与每日剂量当量的Dex治疗和生理盐水对照相比，有效降低了蛋白尿水平，改善了FSGS病变，恢复了肾功能。此外，PEG-Dex治疗也显示出比Dex更好的安全性，并且检测到最小的不良事件。综上所述，这些数据表明PEG-Dex可能是一种更有效、更安全的FSGS临床治疗药物。

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引用次数: 0

Soft bioelectronics for the diagnosis and treatment of heart diseases 软性生物电子学用于心脏疾病的诊断和治疗

Q1 Engineering

Smart Materials in Medicine

Pub Date : 2024-12-15 DOI: 10.1016/j.smaim.2024.12.002

Guangbo Ji , Wenjin Li , Yian Su , Tianjiao Cao , Meng Qian , Huan Wang , Qiang Zhao

Soft bioelectronics is a type of innovative technology that creates electronic devices of organic or inorganic materials on flexible/ductile substrate, holding tremendous promise for the diagnosis and treatment of different diseases. The soft bioelectronic devices, when seamlessly in contact with the heart's surface, facilitate real-time monitoring of crucial parameters such as volume, pressure, and electrophysiological signals, which are indispensable for diagnosing disorders such as ischemic heart disease, arrhythmias, and heart failure. Additionally, integrating electrical and optical stimulation units into these soft bioelectronic devices could lead to significant improvements in cardiac electrophysiology. This review comprehensively covers recent progress in the development of soft bioelectronic devices for management of heart diseases, highlighting the technical challenges and future prospects in this field.

软生物电子学是一种在柔性/延展性基底上制造有机或无机材料电子器件的创新技术，对不同疾病的诊断和治疗具有巨大的前景。当软生物电子设备与心脏表面无缝接触时，便于实时监测诸如体积、压力和电生理信号等关键参数，这对于诊断缺血性心脏病、心律失常和心力衰竭等疾病是必不可少的。此外，将电和光刺激单元集成到这些软生物电子设备中可以显著改善心脏电生理。本文综述了用于心脏疾病管理的软生物电子器件的最新进展，重点介绍了该领域的技术挑战和未来前景。

引用次数: 0

Bioactive matters based on natural product for cardiovascular diseases 基于天然产物的生物活性物质治疗心血管疾病

Q1 Engineering

Smart Materials in Medicine

Pub Date : 2024-11-16 DOI: 10.1016/j.smaim.2024.11.001

Linfang Zhong , Xiaoying Tan , Wenhui Yang , Peishan Li , Lianbao Ye , Qi Luo , Honghao Hou

Natural products are valuable sources of bioactive compounds for drug development. It is useful to explore natural products to treat cardiovascular disease. This review provides an overview of the natural products, including their general sources, structure types, functional methods, applications for cardiovascular diseases and future challenges. We highlight recent advances in drug delivery systems of natural products applicated in cardiovascular diseases such as nanoparticles, microspheres and hydrogels, and outline general strategies for functionalizing the natural product with various biological. Finally, we propose our perspective on challenges and future developments in this rapidly-evolving field.

天然产品是药物开发所需的生物活性化合物的宝贵来源。研究天然产物对治疗心血管疾病很有帮助。本综述概述了天然产物，包括其一般来源、结构类型、功能方法、在心血管疾病中的应用以及未来的挑战。我们重点介绍了应用于心血管疾病的天然产物给药系统的最新进展，如纳米颗粒、微球和水凝胶，并概述了天然产物与各种生物功能化的一般策略。最后，我们对这一快速发展领域的挑战和未来发展提出了自己的看法。

引用次数: 0

Current situation and challenges of polyhydroxyalkanoates-derived nanocarriers for cancer therapy 用于癌症治疗的聚羟基烷酸酯纳米载体的现状与挑战

Q1 Engineering

Smart Materials in Medicine

Pub Date : 2024-10-30 DOI: 10.1016/j.smaim.2024.10.004

Xiao-Yun Huang , Zheng-Dong Qi , Jin-Wei Dao , Dai-Xu Wei

The sustained-release system for chemotherapeutic drugs or photosensitizer based on drug-loaded biopolyester nanocarriers can effectively reduce the overall dosage and frequency of administration, thereby mitigating side effects such as immunosuppression and drug resistance caused by prolonged chemotherapy. Compared to polylactic acid (PLA), microorganism-derived polyhydroxyalkanoates (PHAs) exhibits superior biocompatibility and more flexible drug release behavior due to their diverse monomer compositions, slower degradation behavior, and milder acidic degradation products, 3-hydroxybutyric acid (3HB). It explains PHAs are more suitable carriers for chemotherapeutic drugs. In this review, we summarize the current situation of PHA-derived nanocarriers (PHA-NCs) for cancer therapy, including the advantages, preparation methods, and anticancer applications. Furthermore, we also analyzed the current limitations in the application of PHA-NCs for cancer therapy and proposed existing challenges along with strategies for future development. With the rapid advancements in synthetic biology and nanomedicine, we believe that PHA will once again attract significant attention.

基于载药生物聚酯纳米载体的化疗药物或光敏剂缓释系统可有效减少总体剂量和给药频率，从而减轻长期化疗引起的免疫抑制和耐药性等副作用。与聚乳酸（PLA）相比，微生物衍生的聚羟基烷酸酯（PHA）因其单体成分多样、降解行为缓慢、降解产物 3-hydroxybutyric acid（3HB）酸性较弱等特点，具有更优越的生物相容性和更灵活的药物释放行为。这说明 PHAs 更适合作为化疗药物的载体。在这篇综述中，我们总结了PHA衍生纳米载体（PHA-NCs）用于癌症治疗的现状，包括其优势、制备方法和抗癌应用。此外，我们还分析了目前 PHA-NCs 在癌症治疗中应用的局限性，并提出了现有挑战和未来发展策略。随着合成生物学和纳米医学的快速发展，我们相信 PHA 将再次引起人们的广泛关注。

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引用次数: 0

Nanobody-as versatile tool emerging in autoimmune diseases 纳米体--自身免疫性疾病中出现的多功能工具

Q1 Engineering

Smart Materials in Medicine

Pub Date : 2024-10-18 DOI: 10.1016/j.smaim.2024.10.003

Ling Wang , Ran Luo , Weilang Zhang , Hanyu Jiang , Yongkang Yu , Wenhu Zhou , Fan Zhang , Jian Ma , Lin Mei

Nanobody (Nb) is derived from the variable domain of heavy-chain antibody (HCAb), naturally displaying notable properties like nano-scale size, exceptional stability, high specificity, low immunogenicity, and cryptic epitope accessibility. These features contribute to its great therapeutic potential as a valuable research tool across diverse diseases, especially autoimmune diseases (AIDs). Caplacizumab (Cablivi®) is the first nanobody drug approved for treating acquired thrombotic thrombocytopenic purpura (aTTP). This review summarizes the biomolecular structure, usage of Nb as a foundation of recombinant constructs, and biochemical properties of nanobodies. As attractive therapeutic candidates, many clinical trials of Nbs have been conducted, elucidating potential therapeutic strategies for AIDs. Therefore, the preclinical development and application of Nbs in AIDs are emphasized throughout this review.

纳米抗体（Nb）源自重链抗体（HCAb）的可变结构域，天然具有纳米级尺寸、超强稳定性、高特异性、低免疫原性和表位隐蔽性等显著特性。这些特性使其具有巨大的治疗潜力，成为各种疾病，尤其是自身免疫性疾病（AIDs）的重要研究工具。卡普拉珠单抗（Cablivi®）是首个获准用于治疗获得性血栓性血小板减少性紫癜（aTTP）的纳米抗体药物。本综述概述了纳米抗体的生物分子结构、作为重组构建物基础的 Nb 的使用以及纳米抗体的生化特性。作为极具吸引力的候选治疗药物，Nbs 已经开展了许多临床试验，阐明了治疗艾滋病的潜在策略。因此，本综述强调了 Nbs 在艾滋病中的临床前开发和应用。

引用次数: 0

Bioactive MXene hydrogel promotes structural and functional regeneration of skeletal muscle through improving autophagy and muscle innervation 生物活性 MXene 水凝胶通过改善自噬和肌肉神经支配促进骨骼肌的结构和功能再生

Q1 Engineering

Smart Materials in Medicine

Pub Date : 2024-10-12 DOI: 10.1016/j.smaim.2024.10.002

Li Zhou , Haixia Zhuang , Xinyu Ye , Wei Yuan , Kai Wang , Donghan Hu , Xiangya Luo , Qiuyu Zhang

Complete skeletal muscle regeneration after traumatic injuries remains a challenge due to impaired regenerative capability and dysregulated microenvironments. Autophagy plays a crucial role in the muscle regeneration process by regulating myogenic and non-myogenic cells. Herein, we report a bioactive MXene hydrogel (FPGM) capable of upregulating autophagy and increasing muscle innervation to restore skeletal muscle structure and function. FPGM possessed excellent electrical conductivity, tissue adhesive ability and antioxidation, which could eliminate excess reactive oxygen species to reduce oxidative stress and decrease the secretion of pro-inflammatory cytokine. FPGM upregulated the autophagy level of myoblasts and promoted the migration and tube formation of endothelial cells as well as myogenic differentiation with negligible toxicity. FPGM accelerated muscle fiber formation and skeletal muscle regeneration by improving autophagy, which could regulate microenvironment through raising M2 macrophages to alleviate excessive inflammation, facilitating angiogenesis and decreasing fibrous scar tissue formation in vivo. Importantly, FPGM could efficiently restore muscle function by improving muscle innervation, tibialis anterior compound muscle action potential amplitude and neuromuscular conduction. This work demonstrates that bioactive MXene hydrogel should be a promising candidate for complete skeletal muscle regeneration.

由于再生能力受损和微环境失调，创伤后骨骼肌的完全再生仍是一项挑战。自噬通过调节成肌细胞和非成肌细胞，在肌肉再生过程中发挥着至关重要的作用。在此，我们报告了一种生物活性 MXene 水凝胶（FPGM），它能够上调自噬并增加肌肉神经支配，从而恢复骨骼肌的结构和功能。FPGM具有良好的导电性、组织粘附性和抗氧化性，能消除过量的活性氧，从而降低氧化应激，减少促炎细胞因子的分泌。FPGM 能提高成肌细胞的自噬水平，促进内皮细胞的迁移和管形成，并促进成肌细胞的分化，其毒性几乎可以忽略不计。FPGM可通过提高自噬水平加速肌纤维的形成和骨骼肌的再生，并可通过提高M2巨噬细胞来调节微环境，从而缓解过度炎症，促进血管生成，减少体内纤维瘢痕组织的形成。重要的是，FPGM 可通过改善肌肉神经支配、胫骨前复合肌动作电位振幅和神经肌肉传导，有效恢复肌肉功能。这项研究表明，生物活性 MXene 水凝胶有望成为骨骼肌完全再生的候选材料。

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引用次数: 0